Product References
Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis.
JID innovations : skin science from molecules to population health
Niehues H,Rikken G,van Vlijmen-Willems IMJJ,Rodijk-Olthuis D,van Erp PEJ,Zeeuwen PLJM,Schalkwijk J,van den Bogaard EH
200-08 was used in In vitro experiments to investigate the mitogens involved in keratinocyte proliferation and stratification.
Sat Jan 01 00:00:00 EST 2022
Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes.
Cancers
Erlichman N,Baram T,Meshel T,Morein D,Da'adoosh B,Ben-Baruch A
200-08 was used in Enzyme-linked immunosorbent assay to investigate the role of WT-PD-L1 in triple-negative breast cancer.
Fri Feb 18 00:00:00 EST 2022
Leukocytes from Patients with Drug-Sensitive and Multidrug-Resistant Tuberculosis Exhibit Distinctive Profiles of Chemokine Receptor Expression and Migration Capacity.
Journal of immunology research
Ocaña-Guzmán R,Téllez-Navarrete NA,Ramón-Luing LA,Herrera I,De Ita M,Carrillo-Alduenda JL,Choreño-Parra JA,Medina-Quero K,Zúñiga J,Chávez-Galán L
Mon Nov 29 00:00:00 EST 2021
Reconstruction of Ultra-thin Alveolar-capillary Basement Membrane Mimics.
Advanced biology
Jain P,Nishiguchi A,Linz G,Wessling M,Ludwig A,Rossaint R,Möller M,Singh S
Sun Aug 01 00:00:00 EDT 2021
Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells.
Cells
Morein D,Rubinstein-Achiasaf L,Brayer H,Dorot O,Pichinuk E,Ben-Yaakov H,Meshel T,Pasmanik-Chor M,Ben-Baruch A
200-08 was used in Enzyme-linked immunosorbent assay to demonstrate that a continuous stimulation (~6 weeks) of triple-negative breast tumor cells (TNBC) by the proinflammatory cytokines tumor necrosis factor α (TNFα) + interleukin 1β (IL-1β) changed the expression of hundreds of genes, skewing the cells towards a proinflammatory phenotype which promotes a prometastatic cascade.
Mon May 31 00:00:00 EDT 2021
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
Nature communications
Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q
Wed Jul 21 00:00:00 EDT 2021
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
Nature communications
Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q
Wed Jul 21 00:00:00 EDT 2021
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity.
Nature genetics
Kinker GS,Greenwald AC,Tal R,Orlova Z,Cuoco MS,McFarland JM,Warren A,Rodman C,Roth JA,Bender SA,Kumar B,Rocco JW,Fernandes PACM,Mader CC,Keren-Shaul H,Plotnikov A,Barr H,Tsherniak A,Rozenblatt-Rosen O,Krizhanovsky V,Puram SV,Regev A,Tirosh I
Sun Nov 01 00:00:00 EDT 2020
The LTB4-BLT1 axis regulates actomyosin and β2-integrin dynamics during neutrophil extravasation.
The Journal of cell biology
Subramanian BC,Melis N,Chen D,Wang W,Gallardo D,Weigert R,Parent CA
Mon Oct 05 00:00:00 EDT 2020
Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody.
mAbs
Boyles JS,Beidler CB,Strifler BA,Girard DS,Druzina Z,Durbin JD,Swearingen ML,Lee LN,Kikly K,Chintharlapalli S,Witcher DR
200-08 was used in In vivo experiments to describe the generation and characterization of LY3041658 that binds and neutralizes all seven human and cynomolgus monkey ELR+CXC chemokines and three of five mouse and rat ELR+CXC chemokines with high affinity.
Mon Sep 20 00:00:00 EDT 2021
Metformin suppresses HIF-1α expression in cancer-associated fibroblasts to prevent tumor-stromal cross talk in breast cancer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Shao S,Zhao L,An G,Zhang L,Jing X,Luo M,Li W,Meng D,Ning Q,Zhao X,Lei J
Sat Aug 01 00:00:00 EDT 2020
Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival.
Nature communications
Dietachmayr M,Rathakrishnan A,Karpiuk O,von Zweydorf F,Engleitner T,Fernández-Sáiz V,Schenk P,Ueffing M,Rad R,Eilers M,Gloeckner CJ,Clemm von Hohenberg K,Bassermann F
200-08 was used in Cell Culture to find that CDC14B antagonizes CDK1-mediated activating mitotic phosphorylation of the deubiquitinase USP9X at serine residue 2563, which we show to be essential for USP9X to mediate mitotic survival.
Mon Mar 09 00:00:00 EDT 2020
Chemokines as the modulators of endometrial epithelial cells remodelling.
Scientific reports
Złotkowska A,Andronowska A
Tue Sep 10 00:00:00 EDT 2019
Chemokines as the modulators of endometrial epithelial cells remodelling.
Scientific reports
Złotkowska A,Andronowska A
Tue Sep 10 00:00:00 EDT 2019
Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition.
Nature communications
Pereira BI,Devine OP,Vukmanovic-Stejic M,Chambers ES,Subramanian P,Patel N,Virasami A,Sebire NJ,Kinsler V,Valdovinos A,LeSaux CJ,Passos JF,Antoniou A,Rustin MHA,Campisi J,Akbar AN
Mon Jun 03 00:00:00 EDT 2019
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
The Journal of biological chemistry
Lee AW,Deruaz M,Lynch C,Davies G,Singh K,Alenazi Y,Eaton JRO,Kawamura A,Shaw J,Proudfoot AEI,Dias JM,Bhattacharya S
Fri Jul 19 00:00:00 EDT 2019
LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.
Cell reports
Huang C,Hedl M,Ranjan K,Abraham C
200-08 was used in Cell Culture to investigate that, if, upon stimulation of the pattern-recognition receptor (PRR) NOD2, LACC1 localizes to the endoplasmic reticulum (ER) and forms a complex with ER-stress sensors.
Tue Dec 24 00:00:00 EST 2019
Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer.
Cell death & disease
Zhang R,Qi F,Zhao F,Li G,Shao S,Zhang X,Yuan L,Feng Y
Wed Mar 20 00:00:00 EDT 2019
Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer.
Cell death & disease
Zhang R,Qi F,Zhao F,Li G,Shao S,Zhang X,Yuan L,Feng Y
Wed Mar 20 00:00:00 EDT 2019
Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma.
Cell death & disease
Hasan T,Caragher SP,Shireman JM,Park CH,Atashi F,Baisiwala S,Lee G,Guo D,Wang JY,Dey M,Wu M,Lesniak MS,Horbinski CM,James CD,Ahmed AU
Fri Mar 29 00:00:00 EDT 2019
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Cell
Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E
200-08 was used in In vitro experiments to report here an unexpected finding that macrophages after antibody-dependent cellular cytotoxicity inhibit NK cell-mediated antibody-dependent cellular cytotoxicity and T cell-mediated cytotoxicity in breast cancers and lymphomas.
Thu Oct 04 00:00:00 EDT 2018
Increased α2-6 sialylation of endometrial cells contributes to the development of endometriosis.
Experimental & molecular medicine
Choi HJ,Chung TW,Choi HJ,Han JH,Choi JH,Kim CH,Ha KT
Wed Dec 12 00:00:00 EST 2018
Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines.
Virulence
Liu J,Ma'ayeh S,Peirasmaki D,Lundström-Stadelmann B,Hellman L,Svärd SG
200-08 was used in In vitro experiments to characterise the role of the three main cysteine proteases secreted by Giardia intestinalis in the development of Giardiasis.
Mon Dec 31 00:00:00 EST 2018
Synthesis of Human Neutrophil Extracellular Traps Contributes to Angiopoietin-Mediated In Vitro Proinflammatory and Proangiogenic Activities.
Journal of immunology (Baltimore, Md. : 1950)
Lavoie SS,Dumas E,Vulesevic B,Neagoe PE,White M,Sirois MG
Fri Jun 01 00:00:00 EDT 2018
Novel Anti-Inflammatory Peptides Based on Chemokine-Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
McNaughton EF,Eustace AD,King S,Sessions RB,Kay A,Farris M,Broadbridge R,Kehoe O,Kungl AJ,Middleton J
Tue May 01 00:00:00 EDT 2018
Novel Anti-Inflammatory Peptides Based on Chemokine-Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
McNaughton EF,Eustace AD,King S,Sessions RB,Kay A,Farris M,Broadbridge R,Kehoe O,Kungl AJ,Middleton J
Tue May 01 00:00:00 EDT 2018
Novel Anti-Inflammatory Peptides Based on Chemokine-Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
McNaughton EF,Eustace AD,King S,Sessions RB,Kay A,Farris M,Broadbridge R,Kehoe O,Kungl AJ,Middleton J
Tue May 01 00:00:00 EDT 2018
CXCR1/Akt signaling activation induced by mesenchymal stem cell-derived IL-8 promotes osteosarcoma cell anoikis resistance and pulmonary metastasis.
Cell death & disease
Du L,Han XG,Tu B,Wang MQ,Qiao H,Zhang SH,Fan QM,Tang TT
Mon Jun 18 00:00:00 EDT 2018
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.
Scientific reports
Alenazi Y,Singh K,Davies G,Eaton JRO,Elders P,Kawamura A,Bhattacharya S
Fri Apr 20 00:00:00 EDT 2018
CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration In Vivo through Interference with Glycosaminoglycan Interactions.
Frontiers in immunology
Vanheule V,Boff D,Mortier A,Janssens R,Petri B,Kolaczkowska E,Kubes P,Berghmans N,Struyf S,Kungl AJ,Teixeira MM,Amaral FA,Proost P
Sun Nov 12 00:00:00 EST 2023
miR-29b regulates expression of collagens I and III in chondrogenically differentiating BMSC in an osteoarthritic environment.
Scientific reports
Mayer U,Benditz A,Grässel S
Mon Oct 16 00:00:00 EDT 2017
A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma.
Scientific reports
Zhang Y,Wu Y,Qi H,Xiao J,Gong H,Zhang Y,Xu E,Li S,Ma D,Wang Y,Li W,Shen H
Wed Nov 08 00:00:00 EST 2017
Increased expression of Siglec-9 in chronic obstructive pulmonary disease.
Scientific reports
Zeng Z,Li M,Wang M,Wu X,Li Q,Ning Q,Zhao J,Xu Y,Xie J
Thu Aug 31 00:00:00 EDT 2017
Increased expression of Siglec-9 in chronic obstructive pulmonary disease.
Scientific reports
Zeng Z,Li M,Wang M,Wu X,Li Q,Ning Q,Zhao J,Xu Y,Xie J
Thu Aug 31 00:00:00 EDT 2017
Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.
Scientific reports
Yagawa Y,Robertson-Tessi M,Zhou SL,Anderson ARA,Mulé JJ,Mailloux AW
Wed Nov 22 00:00:00 EST 2017
MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane.
The Journal of clinical investigation
Kurz AR,Pruenster M,Rohwedder I,Ramadass M,Schäfer K,Harrison U,Gouveia G,Nussbaum C,Immler R,Wiessner JR,Margraf A,Lim DS,Walzog B,Dietzel S,Moser M,Klein C,Vestweber D,Haas R,Catz SD,Sperandio M
Tue Nov 01 00:00:00 EDT 2016
Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells.
Stem cells (Dayton, Ohio)
Tuccitto A,Tazzari M,Beretta V,Rini F,Miranda C,Greco A,Santinami M,Patuzzo R,Vergani B,Villa A,Manenti G,Cleris L,Giardiello D,Alison M,Rivoltini L,Castelli C,Perego M
Sat Oct 01 00:00:00 EDT 2016
CXCR2 modulates bone marrow vascular repair and haematopoietic recovery post-transplant.
British journal of haematology
Hale SJ,Hale AB,Zhang Y,Sweeney D,Fisher N,van der Garde M,Grabowska R,Pepperell E,Channon K,Martin-Rendon E,Watt SM
Fri May 01 00:00:00 EDT 2015
MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.
Nature communications
Riesenberg S,Groetchen A,Siddaway R,Bald T,Reinhardt J,Smorra D,Kohlmeyer J,Renn M,Phung B,Aymans P,Schmidt T,Hornung V,Davidson I,Goding CR,Jönsson G,Landsberg J,Tüting T,Hölzel M
Wed Nov 04 00:00:00 EST 2015
The Positively Charged COOH-terminal Glycosaminoglycan-binding CXCL9(74-103) Peptide Inhibits CXCL8-induced Neutrophil Extravasation and Monosodium Urate Crystal-induced Gout in Mice.
The Journal of biological chemistry
Vanheule V,Janssens R,Boff D,Kitic N,Berghmans N,Ronsse I,Kungl AJ,Amaral FA,Teixeira MM,Van Damme J,Proost P,Mortier A
Fri Aug 28 00:00:00 EDT 2015
The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells.
BMC cancer
Leibovich-Rivkin T,Liubomirski Y,Meshel T,Abashidze A,Brisker D,Solomon H,Rotter V,Weil M,Ben-Baruch A
200-08 was used in Enzyme-linked immunosorbent assay to determine the relative contribution of two processes to breast cancer progression: (1) Intrinsic events, such as activation of the Ras pathway and down-regulation of p53; (2) The inflammatory cytokines TNFα and IL-1β, shown in our published studies to be highly expressed in tumors of >80% of breast cancer patients with recurrent disease.
Thu Mar 06 00:00:00 EST 2014
Progression of luminal breast tumors is promoted by ménage à trois between the inflammatory cytokine TNFα and the hormonal and growth-supporting arms of the tumor microenvironment.
Mediators of inflammation
Weitzenfeld P,Meron N,Leibovich-Rivkin T,Meshel T,Ben-Baruch A
200-08 was used in Enzyme-linked immunosorbent assay to indicate that TNF α can turn into a strong prometastatic factor, suggesting a paradigm shift in which clinically approved inhibitors of TNFα would be applied in breast cancer therapy.
Thu Jun 05 00:00:00 EDT 2014
Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model.
Journal of translational medicine
Touboul C,Lis R,Al Farsi H,Raynaud CM,Warfa M,Althawadi H,Mery E,Mirshahi M,Rafii A
Thu Jan 31 00:00:00 EST 2013
Spindle shaped human mesenchymal stem/stromal cells from amniotic fluid promote neovascularization.
PloS one
Roubelakis MG,Tsaknakis G,Pappa KI,Anagnou NP,Watt SM
Fri Sep 06 00:00:00 EDT 2013
Inactivation of staphylococcal phenol soluble modulins by serum lipoprotein particles.
PLoS pathogens
Surewaard BG,Nijland R,Spaan AN,Kruijtzer JA,de Haas CJ,van Strijp JA
Mon Jul 09 00:00:00 EDT 2012
Transgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralization.
PloS one
Sachdeva R,Bhardwaj N,Huhtaniemi I,Aggrawal U,Jain SK,Zaidi R,Singh O,Pal R
Tue May 28 00:00:00 EDT 2013
Downregulation of the AU-rich RNA-binding protein ZFP36 in chronic HBV patients: implications for anti-inflammatory therapy.
PloS one
Jin WJ,Chen CF,Liao HY,Gong LL,Yuan XH,Zhao BB,Zhang D,Feng X,Liu JJ,Wang Y,Chen GF,Yan HP,He YW
Mon Aug 20 00:00:00 EDT 2012
Streptococcus pyogenes SpyCEP influences host-pathogen interactions during infection in a murine air pouch model.
PloS one
Chiappini N,Seubert A,Telford JL,Grandi G,Serruto D,Margarit I,Janulczyk R
Tue Apr 02 00:00:00 EDT 2013
Streptococcus pyogenes SpyCEP influences host-pathogen interactions during infection in a murine air pouch model.
PloS one
Chiappini N,Seubert A,Telford JL,Grandi G,Serruto D,Margarit I,Janulczyk R
Tue Apr 02 00:00:00 EDT 2013
Constitutive and treatment-induced CXCL8-signalling selectively modulates the efficacy of anti-metabolite therapeutics in metastatic prostate cancer.
PloS one
Wilson C,Maxwell PJ,Longley DB,Wilson RH,Johnston PG,Waugh DJ
Wed Sep 19 00:00:00 EDT 2012
Chemokines and inflammatory mediators interact to regulate adult murine neural precursor cell proliferation, survival and differentiation.
PloS one
Turbic A,Leong SY,Turnley AM
Fri Feb 10 00:00:00 EST 2012
Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan.
Journal of immunology (Baltimore, Md. : 1950)
Abu-Taha M,Rius C,Hermenegildo C,Noguera I,Cerda-Nicolas JM,Issekutz AC,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ
Wed Jul 15 00:00:00 EDT 2009
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B
Sat Aug 01 00:00:00 EDT 2009
Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions.
The Journal of biological chemistry
Barth MC,Ahluwalia N,Anderson TJ,Hardy GJ,Sinha S,Alvarez-Cardona JA,Pruitt IE,Rhee EP,Colvin RA,Gerszten RE
Fri Jul 17 00:00:00 EDT 2009
Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.
The Journal of experimental medicine
Proost P,Loos T,Mortier A,Schutyser E,Gouwy M,Noppen S,Dillen C,Ronsse I,Conings R,Struyf S,Opdenakker G,Maudgal PC,Van Damme J
Mon Sep 01 00:00:00 EDT 2008
PEPOP: computational design of immunogenic peptides.
BMC bioinformatics
Moreau V,Fleury C,Piquer D,Nguyen C,Novali N,Villard S,Laune D,Granier C,Molina F
Wed Jan 30 00:00:00 EST 2008
A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles.
Blood
Mateo T,Naim Abu Nabah Y,Losada M,Estellés R,Company C,Bedrina B,Cerdá-Nicolás JM,Poole S,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ
Sat Sep 15 00:00:00 EDT 2007
The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps.
The Journal of experimental medicine
Jaillon S,Peri G,Delneste Y,Frémaux I,Doni A,Moalli F,Garlanda C,Romani L,Gascan H,Bellocchio S,Bozza S,Cassatella MA,Jeannin P,Mantovani A
Mon Apr 16 00:00:00 EDT 2007
Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils.
American journal of physiology. Lung cellular and molecular physiology
Fudala R,Krupa A,Matthay MA,Allen TC,Kurdowska AK
Wed Aug 01 00:00:00 EDT 2007
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.
Cancer research
Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT
Sat Feb 15 00:00:00 EST 2003
Fibrin regulation of interleukin-8 gene expression in human vascular endothelial cells.
Blood
Qi J,Goralnick S,Kreutzer DL
Sat Nov 01 00:00:00 EST 1997
IL-8 in septic shock, endotoxemia, and after IL-1 administration.
Journal of immunology (Baltimore, Md. : 1950)
Van Zee KJ,DeForge LE,Fischer E,Marano MA,Kenney JS,Remick DG,Lowry SF,Moldawer LL
Wed May 15 00:00:00 EDT 1991
