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Product Details
300-58-20UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Published species
Human
Expression System
E. coli
Amino acid sequence
APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN
Molecular weight
7.7 kDa
Class
Recombinant
Type
Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Determined by its ability to chemoattract CCR5-transfected cells using a concentration of 0.1-10.0 ng/ml
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
Recombinant Human LAG-1 is a 7.7 kDa protein containing 69 amino acid residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
LAG-1 is CC chemokine that signals through the CCR5 receptor. LAG-1 is identical to MIP-1beta (ACT II isotype) except for two amino acid substitutions; arginine for histidine at position 22 and serine for glycine at position 47 of the mature protein. LAG-1 chemoattracts monocytes, and exhibits activity as an HIV-suppressive factor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ACT-2; C-C motif chemokine 4; C-C motif chemokine 4-like; CC chemokine ligand 4L1; chemokine (C-C motif) ligand 4-like 1; chemokine (C-C motif) ligand 4-like 1, telomeric; G-26 T-lymphocyte-secreted protein; HC21; LAG-1; lymphocyte activation gene 1; Lymphocyte activation gene 1 protein; Macrophage inflammatory protein 1-beta; macrophage inflammatory protein-1b2; MIP-1-beta; MIP-1-beta(1-69); Monocyte adherence-induced protein 5-alpha; PAT 744; Protein H400; SIS-gamma; small inducible cytokine A4-like; Small-inducible cytokine A4; Small-inducible cytokine A4-like; T-cell activation protein 2
Gene Aliases: AT744.2; CCL4; CCL4L; CCL4L1; CCL4L2; LAG-1; LAG1; MIP-1-beta; MIP1B; SCYA4; SCYA4L; SCYA4L1; SCYA4L2
UniProt ID: (Human) Q569J2
Entrez Gene ID: (Human) 388372
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