Gibco

Human LEC (CCL16) Recombinant Protein, PeproTech®

Human LEC (CCL16) Protein in Functional Assay (Functional)

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Human LEC (CCL16) Protein (300-44-20UG) in Functional

Bioassay analysis of Human LEC (CCL16) Recombinant Protein, PeproTech® (Product # 300-44-1MG).

Product Image Gallery

Product Details

300-44-20UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

View 2 publications 2 publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 10 publications 10 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Immunostaining (IS)

View 1 publication 1 publication

Product Specifications

Species

Human

Published species

Bacteria, Human, Mouse

Expression System

E. coli

Amino acid sequence

QPKVPEWVNT PSTCCLKYYE KVLPRRLVVG YRKALNCHLP AIIFVTKRNR EVCTNPNDDW VQEYIKDPNL PLLPTRNLST VKIITAKNGQ PQLLNSQ

Molecular weight

11.2 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to chemoattract total human monocytes using a concentration range of 10-100 ng/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

CCL16 gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL16 displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.

The Journal of biological chemistry

Lee AW,Deruaz M,Lynch C,Davies G,Singh K,Alenazi Y,Eaton JRO,Kawamura A,Shaw J,Proudfoot AEI,Dias JM,Bhattacharya S

Fri Jul 19 00:00:00 EDT 2019

Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.

Scientific reports

Alenazi Y,Singh K,Davies G,Eaton JRO,Elders P,Kawamura A,Bhattacharya S

Fri Apr 20 00:00:00 EDT 2018

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

Scientific reports

Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S

Tue Jun 27 00:00:00 EDT 2017

Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.

Scientific reports

Yagawa Y,Robertson-Tessi M,Zhou SL,Anderson ARA,Mulé JJ,Mailloux AW

Wed Nov 22 00:00:00 EST 2017

Host chemokines bind to Staphylococcus aureus and stimulate protein A release.

The Journal of biological chemistry

Yung SC,Parenti D,Murphy PM

Fri Feb 18 00:00:00 EST 2011

A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.

Journal of immunology (Baltimore, Md. : 1950)

Izhak L,Wildbaum G,Zohar Y,Anunu R,Klapper L,Elkeles A,Seagal J,Yefenof E,Ayalon-Soffer M,Karin N

Wed Jul 01 00:00:00 EDT 2009

Structure and function of A41, a vaccinia virus chemokine binding protein.

PLoS pathogens

Bahar MW,Kenyon JC,Putz MM,Abrescia NG,Pease JE,Wise EL,Stuart DI,Smith GL,Grimes JM

Tue Jan 01 00:00:00 EST 2008

CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Cappello P,Fraone T,Barberis L,Costa C,Hirsch E,Elia AR,Caorsi C,Musso T,Novelli F,Giovarelli M

Wed Nov 01 00:00:00 EST 2006

Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Lim HW,Broxmeyer HE,Kim CH

Sat Jul 15 00:00:00 EDT 2006

Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist.

The Journal of biological chemistry

Fox JM,Najarro P,Smith GL,Struyf S,Proost P,Pease JE

Fri Dec 01 00:00:00 EST 2006

CCL16 activates an angiogenic program in vascular endothelial cells.

Blood

Strasly M,Doronzo G,Cappello P,Valdembri D,Arese M,Mitola S,Moore P,Alessandri G,Giovarelli M,Bussolino F

Thu Jan 01 00:00:00 EST 2004

LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.

Blood

Howard OM,Dong HF,Shirakawa AK,Oppenheim JJ

Tue Aug 01 00:00:00 EDT 2000

LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.

Blood

Howard OM,Dong HF,Shirakawa AK,Oppenheim JJ

Tue Aug 01 00:00:00 EDT 2000

Tumor rejection and immune memory elicited by locally released LEC chemokine are associated with an impressive recruitment of APCs, lymphocytes, and granulocytes.

Journal of immunology (Baltimore, Md. : 1950)

Giovarelli M,Cappello P,Forni G,Salcedo T,Moore PA,LeFleur DW,Nardelli B,Di Carlo E,Lollini PL,Ruben S,Ullrich S,Garotta G,Musiani P

Wed Mar 15 00:00:00 EST 2000

Tumor rejection and immune memory elicited by locally released LEC chemokine are associated with an impressive recruitment of APCs, lymphocytes, and granulocytes.

Journal of immunology (Baltimore, Md. : 1950)

Giovarelli M,Cappello P,Forni G,Salcedo T,Moore PA,LeFleur DW,Nardelli B,Di Carlo E,Lollini PL,Ruben S,Ullrich S,Garotta G,Musiani P

Wed Mar 15 00:00:00 EST 2000

Bioinformatics

Protein Aliases: C-C motif chemokine 16; chemokine (C-C motif) ligand 16; Chemokine CC-4; Chemokine LEC; HCC-4; IL-10-inducible chemokine; LCC-1; liver CC chemokine-1; Liver-expressed chemokine; LMC; Lymphocyte and monocyte chemoattractant; MGC117051; Monotactin-1; MTN-1; NCC-4; new CC chemokine 4; small inducible cytokine subfamily A (Cys-Cys), member 16; Small-inducible cytokine A16

View more View less

Gene Aliases: CCL16; CKb12; HCC-4; ILINCK; LCC-1; LEC; LMC; Mtn-1; NCC-4; NCC4; SCYA16; SCYL4

Human LEC (CCL16) Recombinant Protein, PeproTech®

Human LEC (CCL16) Protein (300-44-20UG) in Functional

Product Details

300-44-20UG

Western Blot (WB)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Immunostaining (IS)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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