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This peptide corresponds to 14 amino acids near the center of human LGI1.
PEP-0611 can be used as a blocking peptide with polyclonal antibody PA5-20491.
The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Two isoforms of LGI1 are known to exist.
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Protein Aliases: Epitempin 1; Epitempin-1; leucine-rich glioma inactivated 1; Leucine-rich glioma-inactivated protein 1; leucine-rich, glioma inactivated 1; OTTHUMP00000020121; OTTHUMP00000020122
Gene Aliases: ADLTE; ADPAEF; ADPEAF; EPITEMPIN; EPT; ETL1; IB1099; LGI1; UNQ775/PRO1569
UniProt ID: (Human) O95970
Entrez Gene ID: (Human) 9211
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