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Product Details
RP-88078
Product Specifications
Species
Human
Expression System
HEK293 cells
Amino acid sequence
Human LILRA3, amino acids Met1-Glu439 (Accession # AAH28208.1) with a C-terminal human IgG1 Fc region
Tag
Fc-tag
Molecular weight
102 kDa
Class
Recombinant
Type
Protein
Purity
>80% as determined by SDS-PAGE.
Endotoxin concentration
<1.0 EU/µg
Conjugate
Form
Lyophilized
Purification
purified
Storage buffer
PBS, pH 7.4, with 0.01% mannitol, 5-8% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (1493 µL) be added to the vial to prepare a stock solution of 0.67 mg/mL.
Concentration is measured by UV.
Target Information
Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades (see LILRA1, MIM 604810). One member of subfamily A (LILRA3) lacks a transmembrane region and is presumed to be a soluble receptor (Borges et al., 1997 [PubMed 9548455]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD85 antigen-like family member E; CD85e; ILT-6; Immunoglobulin-like transcript 6; leucocyte Ig-like receptor A3; Leukocyte immunoglobulin-like receptor 4; leukocyte immunoglobulin-like receptor A3; Leukocyte immunoglobulin-like receptor subfamily A member 3; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3; LIR-4; Monocyte inhibitory receptor HM43/HM31
Gene Aliases: CD85E; HM31; HM43; ILT-6; ILT6; LILRA3; LIR-4; LIR4
UniProt ID: (Human) Q8N6C8
Entrez Gene ID: (Human) 11026
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