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This peptide corresponds to 16 amino acids near the center of human LRFN3.
PEP-0821 can be used as a blocking peptide with polyclonal antibody PA5-20706.
LRFN3 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system.
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Protein Aliases: fibronectin type III, immunoglobulin and leucine rich repeat domains 1; Leucine-rich repeat and fibronectin type-III domain-containing protein 3; Synaptic adhesion-like molecule 4
Gene Aliases: FIGLER1; LRFN3; SALM4; UNQ5865/PRO34192
UniProt ID: (Human) Q9BTN0
Entrez Gene ID: (Human) 79414
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