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Human M-CSF Recombinant Protein, PeproTech®

Human M-CSF Protein in Functional Assay (Functional)

FIGURE: 1 / 2

Human M-CSF Protein (300-25-10UG) in Functional

Bioassay analysis of Human M-CSF Recombinant Protein, PeproTech® (Product # 300-25-1MG).

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Product Details

300-25-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 458 publications 458 publications

Miscellaneous PubMed (Misc)

View 68 publications 68 publications

Product Specifications

Species

Human

Published species

Bovine, Cat, Dog, Hamster, Human, Mouse, Non-human primate, Rabbit, Rat, Virus

Expression System

E. coli

Amino acid sequence

MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS

Molecular weight

36.8 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NSF-60 cells ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human M-CSF is a 36.8 kDa homodimeric protein consisting of two 159 amino acid polypeptide subunits.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

M-CSF (Macrophage colony-stimulating factor, CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization. M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. Further, M-CSF is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex. Functionally, M-CSF is known to stimulate differentiation of hematopoietic stem cells to monocyte-macrophage cell populations in culture. M-CSF acts through the CSF receptor 1. Although human M-CSF shows activity on mouse cells, mouse CSF shows no activity on human cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Adaptation of Human iPSC-Derived Macrophages Toward an Alveolar Macrophage-Like Phenotype Post-Intra-Pulmonary Transfer into Murine Models.

Methods in molecular biology (Clifton, N.J.)

Hetzel M,Gensch I,Ackermann M,Lachmann N

300-25 was used in In vitro experiments to introduce the use of human-induced pluripotent stem cell (iPSC)-derived primitive macrophages, which can be further matured towards an AM-like phenotype upon intra-pulmonary transfer into mice.

Tue Aug 29 00:00:00 EDT 2023

Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.

British journal of haematology

Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y

300-25 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.

Sat Jul 01 00:00:00 EDT 2023

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Cell metabolism

Wieder N,Fried JC,Kim C,Sidhom EH,Brown MR,Marshall JL,Arevalo C,Dvela-Levitt M,Kost-Alimova M,Sieber J,Gabriel KR,Pacheco J,Clish C,Abbasi HS,Singh S,Rutter JC,Therrien M,Yoon H,Lai ZW,Baublis A,Subramanian R,Devkota R,Small J,Sreekanth V,Han M,Lim D,Carpenter AE,Flannick J,Finucane H,Haigis MC,Claussnitzer M,Sheu E,Stevens B,Wagner BK,Choudhary A,Shaw JL,Pablo JL,Greka A

300-25 was used in Cell Culture to find that c-MAF-inducing protein (CMIP) protects cells from FFA exposure by modulating Akt signaling.

Tue May 02 00:00:00 EDT 2023

Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages.

The Journal of cell biology

Pellegrino E,Aylan B,Bussi C,Fearns A,Bernard EM,Athanasiadi N,Santucci P,Botella L,Gutierrez MG

300-25 was used in In vitro experiments to find peroxisomes increased ROS levels during Mtb WT infection.

Mon Dec 04 00:00:00 EST 2023

Colchicine exerts anti-atherosclerotic and -plaque-stabilizing effects targeting foam cell formation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Schwarz N,Fernando S,Chen YC,Salagaras T,Rao SR,Liyanage S,Williamson AE,Toledo-Flores D,Dimasi C,Sargeant TJ,Manavis J,Eddy E,Kanellakis P,Thompson PL,Tan JTM,Snel MF,Bursill CA,Nicholls SJ,Peter K,Psaltis PJ

300-25 was used in Cell Culture to show that colchicine exerts anti-atherosclerotic and plaque-stabilizing effects at low dose by inhibiting foam cell formation and cholesterol crystal-induced inflammation.

Sat Apr 01 00:00:00 EDT 2023

The adiponectin receptor agonist AdipoAI attenuates periodontitis in diabetic rats by inhibiting gingival fibroblast-induced macrophage migration.

British journal of pharmacology

Qiu W,Wang Z,Chen Z,Sun Q,Wu H,Chen Z,Luan K,Liu Z,Ding D,Tu Q,Chen J,Wu B,Fang F

300-25 was used in Cell Culture to examine chemokine expression levels in hGFs and hGF-induced monocyte/macrophage migration upon siRNA knockdown of Adiponectin receptor expression.

Fri Sep 01 00:00:00 EDT 2023

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.

Molecular psychiatry

Albornoz EA,Amarilla AA,Modhiran N,Parker S,Li XX,Wijesundara DK,Aguado J,Zamora AP,McMillan CLD,Liang B,Peng NYG,Sng JDJ,Saima FT,Fung JN,Lee JD,Paramitha D,Parry R,Avumegah MS,Isaacs A,Lo MW,Miranda-Chacon Z,Bradshaw D,Salinas-Rebolledo C,Rajapakse NW,Wolvetang EJ,Munro TP,Rojas-Fernandez A,Young PR,Stacey KJ,Khromykh AA,Chappell KJ,Watterson D,Woodruff TM

300-25 was used in Cell Culture to support a possible mechanism of microglial innate immune activation by SARS-CoV-2, which could explain the increased vulnerability to developing neurological symptoms akin to Parkinson's disease in COVID-19 infected individuals, and a potential therapeutic avenue for intervention.

Sat Jul 01 00:00:00 EDT 2023

Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells.

Cell reports methods

Tamaoki N,Siebert S,Maeda T,Ha NH,Good ML,Huang Y,Vodnala SK,Haro-Mora JJ,Uchida N,Tisdale JF,Sweeney CL,Choi U,Brault J,Koontz S,Malech HL,Yamazaki Y,Isonaka R,Goldstein DS,Kimura M,Takebe T,Zou J,Stroncek DF,Robey PG,Kruhlak MJ,Restifo NP,Vizcardo R

300-25 was used in Cell Culture to demonstrate that organoid-induced HPCs can be differentiated into erythroid cells, macrophages, and T lymphocytes with current maturation protocols.

Mon Apr 24 00:00:00 EDT 2023

Stereochemistry and functions of the new cysteinyl-resolvin, 4S,5R-RCTR1, in efferocytosis and erythrophagocytosis of human senescent erythrocytes.

American journal of hematology

Nshimiyimana R,Libreros S,Simard M,Chiang N,Rodriguez AR,Spur BW,Haeggström JZ,Serhan CN

300-25 was used in Cell Culture to establish the complete stereochemistry of 4S,5R-RCTR1 as 5R-glutathionyl-4S,17S-dihydroxy-6E,8E,10Z,13Z,15E,19Z-docosahexaenoic acid and give evidence of its novel bioactivities in human phagocyte responses.

Sat Jul 01 00:00:00 EDT 2023

Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration.

Nature protocols

Kang YJ,Diep YN,Tran M,Tran VTA,Ambrin G,Ngo H,Cho H

300-25 was used in In vitro experiments to show that our human BoCs serve as reliable and valuable platforms to investigate pathological mechanisms involving neuroinflammation and to assess therapeutic strategies modulating neuroinflammation in neurological disorders.

Fri Sep 01 00:00:00 EDT 2023

C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages.

iScience

Tian L,Li H,Zhao P,Liu Y,Lu Y,Zhong R,Jin Y,Tan T,Cheng Y

300-25 was used in Cell Culture to provide a comprehensive overview of the cancer-specific immune signature of monocytes and macrophages and reveals tumor-associated biomarkers as potential therapeutic targets for SCLC.

Fri Oct 20 00:00:00 EDT 2023

Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors.

Methods in molecular biology (Clifton, N.J.)

Chen SW,Wong YH

300-25 was used in Cell Culture to provide a stepwise protocol for the simple, robust, and efficient differentiation of hiPSCs into microglia-like cells (iMGs) by overexpression of SPI1 and CEBPA.

Mon Jun 12 00:00:00 EDT 2023

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.

Nature neuroscience

Dräger NM,Sattler SM,Huang CT,Teter OM,Leng K,Hashemi SH,Hong J,Aviles G,Clelland CD,Zhan L,Udeochu JC,Kodama L,Singleton AB,Nalls MA,Ichida J,Ward ME,Faghri F,Gan L,Kampmann M

300-25 was used in In vitro experiments to present a screening platform to systematically elucidate functional consequences of genetic perturbations in human induced pluripotent stem cell-derived microglia.

Thu Sep 01 00:00:00 EDT 2022

CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases.

The Journal of experimental medicine

Zhang B,Zhang Y,Xiong L,Li Y,Zhang Y,Zhao J,Jiang H,Li C,Liu Y,Liu X,Liu H,Ping YF,Zhang QC,Zhang Z,Bian XW,Zhao Y,Hu X

Mon Feb 07 00:00:00 EST 2022

Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors.

Nature protocols

Ackermann M,Rafiei Hashtchin A,Manstein F,Carvalho Oliveira M,Kempf H,Zweigerdt R,Lachmann N

Tue Feb 01 00:00:00 EST 2022

Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer.

EMBO molecular medicine

Zhou Q,Liang J,Yang T,Liu J,Li B,Li Y,Fan Z,Wang W,Chen W,Yuan S,Xu M,Xu Q,Luan Z,Xia Z,Zhou P,Huang Y,Chen L

300-25 was used in Cell Culture to conduct high-throughput screening to show that Carfilzomib potently drives M2 macrophages to express M1 cytokines, phagocytose tumor cells, and present antigens to T cells to suggest a potentially immediate application of combinational treatment with Carfilzomib and PD-1 inhibitors for patients with solid tumors.

Tue Jan 11 00:00:00 EST 2022

Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.

Cellular and molecular life sciences : CMLS

Solomon S,Sampathkumar NK,Carre I,Mondal M,Chennell G,Vernon AC,Ruepp MD,Mitchell JC

300-25 was used in Sample Preparation to investigate P522R in Alzheimer’s disease.

Wed Jul 27 00:00:00 EDT 2022

Staphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acid.

Immunology

Miek L,Jordan PM,Günther K,Pace S,Beyer T,Kowalak D,Hoerr V,Löffler B,Tuchscherr L,Serhan CN,Gerstmeier J,Werz O

Sun May 01 00:00:00 EDT 2022

Concurrent stimulation of monocytes with CSF1 and polarizing cytokines reveals phenotypic and functional differences with classical polarized macrophages.

Journal of leukocyte biology

An L,Michaeli J,Pallavi P,Breedijk A,Xu X,Dietrich N,Sigl M,Keese M,Nitschke K,Jarczyk J,Nuhn P,Krämer BK,Yard BA,Leipe J

Thu Sep 01 00:00:00 EDT 2022

Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis.

JCI insight

Tsao LC,Crosby EJ,Trotter TN,Wei J,Wang T,Yang X,Summers AN,Lei G,Rabiola CA,Chodosh LA,Muller WJ,Lyerly HK,Hartman ZC

300-25 was used in Sample Preparation (FC/FACS) to identify classical complement activation as a significant antitumor MOA for T+P therapy that may be functionally enhanced to potentially augment clinical therapeutic efficacy.

Tue Mar 22 00:00:00 EDT 2022

Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4.

iScience

Colombo G,Travelli C,Porta C,Genazzani AA

300-25 was used in Cell Culture to demonstrate that eNAMPT promotes inflammation by favoring both the recruitment of myeloid cells and the induction of an inflammatory transcriptional program.

Fri Apr 15 00:00:00 EDT 2022

A multi-organ chip with matured tissue niches linked by vascular flow.

Nature biomedical engineering

Ronaldson-Bouchard K,Teles D,Yeager K,Tavakol DN,Zhao Y,Chramiec A,Tagore S,Summers M,Stylianos S,Tamargo M,Lee BM,Halligan SP,Abaci EH,Guo Z,Jacków J,Pappalardo A,Shih J,Soni RK,Sonar S,German C,Christiano AM,Califano A,Hirschi KK,Chen CS,Przekwas A,Vunjak-Novakovic G

300-25 was used in Cell Culture to report the development and applicability of a tissue-chip system in which matured human heart, liver, bone and skin tissue niches are linked by recirculating vascular flow to allow for the recapitulation of interdependent organ functions.

Fri Apr 01 00:00:00 EDT 2022

Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3.

Cell reports

Li Y,Zhu Y,Feng S,Ishida Y,Chiu TP,Saito T,Wang S,Ann DK,Ou JJ

300-25 was used in Cell Culture to report that M1-like macrophages stimulated by HBV exhibit a strong HBV-suppressive effect, which is diminished in M2-like macrophages.

Tue Jan 25 00:00:00 EST 2022

Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor-associated macrophage phenotype.

Clinical and translational medicine

Boibessot C,Molina O,Lachance G,Tav C,Champagne A,Neveu B,Pelletier JF,Pouliot F,Fradet V,Bilodeau S,Fradet Y,Bergeron A,Toren P

300-25 was used in Cell Culture to study the origin, development, and function of tumor-associated macrophages (TAMs) within the prostate tumor microenvironment (TME) to identify the immunosuppressive TAM marker CD163 in adjacent normal epithelium as an independent predictor of metastases or prostate cancer (PCa) death.

Sat Jan 01 00:00:00 EST 2022

TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.

eLife

Jairaman A,McQuade A,Granzotto A,Kang YJ,Chadarevian JP,Gandhi S,Parker I,Smith I,Cho H,Sensi SL,Othy S,Blurton-Jones M,Cahalan MD

300-25 was used in In vitro experiments to show that loss of TREM2 confers a defect in microglial Ca2+ response to purinergic signals, suggesting a window of Ca2+ signaling for optimal microglial motility.

Tue Feb 22 00:00:00 EST 2022

Exosomes derived from M2 macrophages induce angiogenesis to promote wound healing.

Frontiers in molecular biosciences

Lyu L,Cai Y,Zhang G,Jing Z,Liang J,Zhang R,Dang X,Zhang C

300-25 was used in Cell Culture to demonstrate that M2-EXO can be used as a promising nanomedicine strategy for therapeutic exploration of skin healing with the potential to be translated into clinical practice.

Sat Oct 29 00:00:00 EDT 2022

Protocol of Co-Culture of Human Osteoblasts and Osteoclasts to Test Biomaterials for Bone Tissue Engineering.

Methods and protocols

Borciani G,Montalbano G,Baldini N,Vitale-Brovarone C,Ciapetti G

Fri Jan 14 00:00:00 EST 2022

Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization.

iScience

Cheng Y,Yu Y,Zhuang Q,Wang L,Zhan B,Du S,Liu Y,Huang J,Hao J,Zhu X

300-25 was used in Cell Culture to investigate helminths in rheumatoid arthritis treatment.

Fri Mar 18 00:00:00 EDT 2022

Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis.

mBio

Santucci P,Aylan B,Botella L,Bernard EM,Bussi C,Pellegrino E,Athanasiadi N,Gutierrez MG

300-25 was used in Cell Culture to describe a dual live imaging approach to monitor mycobacterial pH homeostasis, host cell environment, and antibiotic action, and show that intracellular localization of M. tuberculosis affects the efficacy of pyrazinamide.

Tue Apr 26 00:00:00 EDT 2022

Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics.

Cellular and molecular gastroenterology and hepatology

Texler B,Zollner A,Reinstadler V,Reider SJ,Macheiner S,Jelusic B,Pfister A,Watschinger C,Przysiecki N,Tilg H,Oberacher H,Moschen AR

300-25 was used in In vitro experiments to describe an unappreciated mechanism-namely induction of equilibrative nucleoside transporters-enhancing baseline cellular uptake that can be inhibited pharmaceutically.

Mon Apr 04 00:00:00 EDT 2022

Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia.

Frontiers in immunology

Wallach T,Raden M,Hinkelmann L,Brehm M,Rabsch D,Weidling H,Krüger C,Kettenmann H,Backofen R,Lehnardt S

300-25 was used in In vitro experiments to determine TLR7 and TLR8 as key sensors of SARS-CoV-2-derived ssRNAs and may deepen our understanding of the mechanisms how this virus triggers, but also modulates an inflammatory response through innate immune signaling.

Tue Jan 31 00:00:00 EST 2023

Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages.

Immunology

Hoyle C,Green JP,Allan SM,Brough D,Lemarchand E

300-25 was used in Cell Culture to highlight itaconate and fumarate derivatives as potential therapeutic options in NLRP3- and IL-1α-driven diseases, including in the brain.

Fri Apr 01 00:00:00 EDT 2022

Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy.

International journal of biological sciences

Gao L,Xu QH,Ma LN,Luo J,Muyayalo KP,Wang LL,Huang DH,Xiao XJ,Cheng SB,Mor G,Liao AH

300-25 was used in Sample Preparation (FC/FACS) to investigate the role of lactic acid metabolism on maternal-fetal interface during early pregnancy.

Mon Mar 21 00:00:00 EDT 2022

Targeting Immunosuppressive Tumor-Associated Macrophages Using Innate T Cells for Enhanced Antitumor Reactivity.

Cancers

Li YR,Brown J,Yu Y,Lee D,Zhou K,Dunn ZS,Hon R,Wilson M,Kramer A,Zhu Y,Fang Y,Yang L

300-25 was used in Sample Preparation (FC/FACS) to evaluate the targeting efficacy CAR-engineered T cells on MAIT, iNKT, and γδT cells.

Wed Jun 01 00:00:00 EDT 2022

Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.

Nature

Kamber RA,Nishiga Y,Morton B,Banuelos AM,Barkal AA,Vences-Catalán F,Gu M,Fernandez D,Seoane JA,Yao D,Liu K,Lin S,Spees K,Curtis C,Jerby-Arnon L,Weissman IL,Sage J,Bassik MC

Wed Sep 01 00:00:00 EDT 2021

Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes.

Circulation

Geisberger S,Bartolomaeus H,Neubert P,Willebrand R,Zasada C,Bartolomaeus T,McParland V,Swinnen D,Geuzens A,Maifeld A,Krampert L,Vogl M,Mähler A,Wilck N,Markó L,Tilic E,Forslund SK,Binger KJ,Stegbauer J,Dechend R,Kleinewietfeld M,Jantsch J,Kempa S,Müller DN

300-25 was used in Cell Culture to investigate effects of sodium changes on human and murine phagocytes.

Tue Jul 13 00:00:00 EDT 2021

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.

Cancer cell

Hara T,Chanoch-Myers R,Mathewson ND,Myskiw C,Atta L,Bussema L,Eichhorn SW,Greenwald AC,Kinker GS,Rodman C,Gonzalez Castro LN,Wakimoto H,Rozenblatt-Rosen O,Zhuang X,Fan J,Hunter T,Verma IM,Wucherpfennig KW,Regev A,Suvà ML,Tirosh I

Mon Jun 14 00:00:00 EDT 2021

M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity.

Signal transduction and targeted therapy

Zhao HY,Zhang YY,Xing T,Tang SQ,Wen Q,Lyu ZS,Lv M,Wang Y,Xu LP,Zhang XH,Kong Y,Huang XJ

Fri Jun 18 00:00:00 EDT 2021

Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation.

Nature immunology

Yao J,Wu D,Zhang C,Yan T,Zhao Y,Shen H,Xue K,Huang X,Wang Z,Qiu Y

Fri Oct 01 00:00:00 EDT 2021

Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.

Science translational medicine

Reyes M,Filbin MR,Bhattacharyya RP,Sonny A,Mehta A,Billman K,Kays KR,Pinilla-Vera M,Benson ME,Cosimi LA,Hung DT,Levy BD,Villani AC,Sade-Feldman M,Baron RM,Goldberg MB,Blainey PC,Hacohen N

Wed Jun 16 00:00:00 EDT 2021

DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis.

The Journal of experimental medicine

Kaifu T,Yabe R,Maruhashi T,Chung SH,Tateno H,Fujikado N,Hirabayashi J,Iwakura Y

Mon Dec 06 00:00:00 EST 2021

The SIRPα-CD47 immune checkpoint in NK cells.

The Journal of experimental medicine

Deuse T,Hu X,Agbor-Enoh S,Jang MK,Alawi M,Saygi C,Gravina A,Tediashvili G,Nguyen VQ,Liu Y,Valantine H,Lanier LL,Schrepfer S

Mon Mar 01 00:00:00 EST 2021

A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.

Brain : a journal of neurology

Magusali N,Graham AC,Piers TM,Panichnantakul P,Yaman U,Shoai M,Reynolds RH,Botia JA,Brookes KJ,Guetta-Baranes T,Bellou E,Bayram S,Sokolova D,Ryten M,Sala Frigerio C,Escott-Price V,Morgan K,Pocock JM,Hardy J,Salih DA

Fri Dec 31 00:00:00 EST 2021

MEF2C regulates osteoclastogenesis and pathologic bone resorption via c-FOS.

Bone research

Fujii T,Murata K,Mun SH,Bae S,Lee YJ,Pannellini T,Kang K,Oliver D,Park-Min KH,Ivashkiv LB

Mon Jan 11 00:00:00 EST 2021

Kdm6a suppresses the alternative activation of macrophages and impairs energy expenditure in obesity.

Cell death and differentiation

Chen J,Xu X,Li Y,Li F,Zhang J,Xu Q,Chen W,Wei Y,Wang X

300-25 was used in Cell Culture to study whether the Kdm6a pathway in adipose tissue macrophages (ATMs), which are involved in metabolic inflammation in obesity, regulate energy homeostasis.

Sat May 01 00:00:00 EDT 2021

Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice.

Glia

Parajuli B,Saito H,Shinozaki Y,Shigetomi E,Miwa H,Yoneda S,Tanimura M,Omachi S,Asaki T,Takahashi K,Fujita M,Nakashima K,Koizumi S

Fri Oct 01 00:00:00 EDT 2021

Mantle cell lymphoma polarizes tumor-associated macrophages into M2-like macrophages, which in turn promote tumorigenesis.

Blood advances

Le K,Sun J,Khawaja H,Shibata M,Maggirwar SB,Smith MR,Gupta M

Tue Jul 27 00:00:00 EDT 2021

The selection of variable regions affects effector mechanisms of IgA antibodies against CD20.

Blood advances

Evers M,Rösner T,Dünkel A,Jansen JHM,Baumann N,Ten Broeke T,Nederend M,Eichholz K,Klausz K,Reiding K,Schewe DM,Kellner C,Peipp M,Leusen JHW,Valerius T

Tue Oct 12 00:00:00 EDT 2021

MED1 Deficiency in Macrophages Accelerates Intimal Hyperplasia via ROS Generation and Inflammation.

Oxidative medicine and cellular longevity

Zhang Y,Fu Y,Zhang C,Jia L,Yao N,Lin Y,Dong Y,Fatima N,Alam N,Wang R,Wang W,Bai L,Zhao S,Liu E

Tue Feb 22 00:00:00 EST 2022

Mutations in Profilin 1 Cause Early-Onset Paget's Disease of Bone With Giant Cell Tumors.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wei Z,Li S,Tao X,Zhu G,Sun Z,Wei Z,Jiao Q,Zhang H,Chen L,Li B,Zhang Z,Yue H

Tue Jun 01 00:00:00 EDT 2021

Mutations in Profilin 1 Cause Early-Onset Paget's Disease of Bone With Giant Cell Tumors.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wei Z,Li S,Tao X,Zhu G,Sun Z,Wei Z,Jiao Q,Zhang H,Chen L,Li B,Zhang Z,Yue H

Tue Jun 01 00:00:00 EDT 2021

Human induced pluripotent stem cell-derived macrophages ameliorate liver fibrosis.

Stem cells (Dayton, Ohio)

Pouyanfard S,Meshgin N,Cruz LS,Diggle K,Hashemi H,Pham TV,Fierro M,Tamayo P,Fanjul A,Kisseleva T,Kaufman DS

Wed Dec 01 00:00:00 EST 2021

Plinabulin, a Distinct Microtubule-Targeting Chemotherapy, Promotes M1-Like Macrophage Polarization and Anti-tumor Immunity.

Frontiers in oncology

Natoli M,Herzig P,Pishali Bejestani E,Buchi M,Ritschard R,Lloyd GK,Mohanlal R,Tonra JR,Huang L,Heinzelmann V,Trüb M,Zippelius A,Kashyap AS

300-25 was used in Cell Culture to investigate plinabulin and the effects on dendritic cell maturation and anti-tumor immunity in mice.

Tue Mar 23 00:00:00 EDT 2021

IRF5 regulates airway macrophage metabolic responses.

Clinical and experimental immunology

Albers GJ,Iwasaki J,McErlean P,Ogger PP,Ghai P,Khoyratty TE,Udalova IA,Lloyd CM,Byrne AJ

Thu Apr 01 00:00:00 EDT 2021

STAT3 Gain-of-Function Mutations Underlie Deficiency in Human Nonclassical CD16⁺ Monocytes and CD141⁺ Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950)

Korenfeld D,Roussak K,Dinkel S,Vogel TP,Pollack H,Levy J,Leiding JW,Milner J,Cooper M,Klechevsky E

Mon Nov 15 00:00:00 EST 2021

HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells.

Stem cells international

Kwon YW,Ahn HS,Lee JW,Yang HM,Cho HJ,Kim SJ,Lee SH,Yang HM,Jang HD,Kim SJ,Kim HS

Tue Jun 08 00:00:00 EDT 2021

Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival.

Journal of neuro-oncology

Crotty EE,Smith SMC,Brasel K,Pakiam F,Girard EJ,Connor YD,Zindy F,Mhyre AJ,Roussel MF,Olson JM

300-25 was used in Cell Culture to investigate the role of tumour-associated macrophage infiltration in cancer progression.

Tue Jun 01 00:00:00 EDT 2021

Type I interferon decreases macrophage energy metabolism during mycobacterial infection.

Cell reports

Olson GS,Murray TA,Jahn AN,Mai D,Diercks AH,Gold ES,Aderem A

Tue Jun 01 00:00:00 EDT 2021

FABP4 deactivates NF-κB-IL1α pathway by ubiquitinating ATPB in tumor-associated macrophages and promotes neuroblastoma progression.

Clinical and translational medicine

Miao L,Zhuo Z,Tang J,Huang X,Liu J,Wang HY,Xia H,He J

Thu Apr 01 00:00:00 EDT 2021

RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia.

Cell reports

Sun R,He L,Lee H,Glinka A,Andresen C,Hübschmann D,Jeremias I,Müller-Decker K,Pabst C,Niehrs C

Tue Aug 17 00:00:00 EDT 2021

Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease.

Cell reports

Tiwari-Heckler S,Yee EU,Yalcin Y,Park J,Nguyen DT,Gao W,Csizmadia E,Afdhal N,Mukamal KJ,Robson SC,Lai M,Schwartz RE,Jiang ZG

Tue Oct 26 00:00:00 EDT 2021

Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion.

iScience

Zhang Y,Guo A,Lyu C,Bi R,Wu Z,Li W,Zhao P,Niu Y,Na J,Xi JJ,Du Y

300-25 was used in Cell Culture to optimize the in vitro liver fibrotic niches and subsequently harvest their bioactive ingredients as niche extracts (NEs) so that pathology-relevant and tissue-specific NEs provide innovative and generalizable strategies for the discovery of optimal cellular niche and bioactive niche compositions.

Fri Nov 19 00:00:00 EST 2021

Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion.

iScience

Zhang Y,Guo A,Lyu C,Bi R,Wu Z,Li W,Zhao P,Niu Y,Na J,Xi JJ,Du Y

Fri Nov 19 00:00:00 EST 2021

EGR1 is a gatekeeper of inflammatory enhancers in human macrophages.

Science advances

Trizzino M,Zucco A,Deliard S,Wang F,Barbieri E,Veglia F,Gabrilovich D,Gardini A

Fri Jan 01 00:00:00 EST 2021

Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures.

Scientific reports

Kennedy JW,Tsimbouri PM,Campsie P,Sood S,Childs PG,Reid S,Young PS,Meek DRM,Goodyear CS,Dalby MJ

Tue Nov 23 00:00:00 EST 2021

HIV Increases the Inhibitory Impact of Morphine and Antiretrovirals on Autophagy in Primary Human Macrophages: Contributions to Neuropathogenesis.

Cells

Barbaro JM,Cuervo AM,Berman JW

300-25 was used in Sample Prep (ELISA) to indicate that inhibition of autophagy, both in bulk and selective, in CNS macrophages may mediate neurocognitive dysfunction in PWH using opioids.

Tue Aug 24 00:00:00 EDT 2021

Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome.

Nature aging

Shchukina I,Bagaitkar J,Shpynov O,Loginicheva E,Porter S,Mogilenko DA,Wolin E,Collins P,Demidov G,Artomov M,Zaitsev K,Sidorov S,Camell C,Bambouskova M,Arthur L,Swain A,Panteleeva A,Dievskii A,Kurbatsky E,Tsurinov P,Chernyatchik R,Dixit VD,Jovanovic M,Stewart SA,Daly MJ,Dmitriev S,Oltz EM,Artyomov MN

300-25 was used in Sample Preparation (PCR) to study the characterization of healthy aging in human classical monocytes, with a focus on epigenomic, transcriptomic, and proteomic alterations, as well as the corresponding proteomic and metabolomic data for plasma, using healthy cohorts of 20 young and 20 older males.

Fri Jan 01 00:00:00 EST 2021

Stem-cell-derived human microglia transplanted into mouse brain to study human disease.

Nature protocols

Fattorelli N,Martinez-Muriana A,Wolfs L,Geric I,De Strooper B,Mancuso R

300-25 was used in Sample Preparation to explain the step-by-step workflow that includes in vitro microglia differentiation from human PSCs, transplantation into the mouse brain and quantitative analysis of engraftment. This approach is more optimized and more efficient approach that yields up to 80% chimerism when compared to current differentiation and xenotransplantation protocols.

Mon Feb 01 00:00:00 EST 2021

Human Serum Enhances Biomimicry of Engineered Tissue Models of Bone and Cancer.

Frontiers in bioengineering and biotechnology

Villasante A,Robinson ST,Cohen AR,Lock R,Guo XE,Vunjak-Novakovic G

300-25 was used in Cell Culture to support the utility of human serum for bioengineering of bone and bone cancers.

Tue Feb 14 00:00:00 EST 2023

The miR-424(322)/503 gene cluster regulates pro- versus anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling.

Cell reports

Zyulina V,Yan KK,Ju B,Schwarzenberger E,Passegger C,Tam-Amersdorfer C,Pan Q,Sconocchia T,Pollack C,Shaner B,Zebisch A,Easton J,Yu J,Silva JM,Strobl H

Tue Apr 27 00:00:00 EDT 2021

Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia.

Nature communications

Bassil R,Shields K,Granger K,Zein I,Ng S,Chih B

Wed Sep 01 00:00:00 EDT 2021

MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages.

Cell reports

Bae S,Park PSU,Lee Y,Mun SH,Giannopoulou E,Fujii T,Lee KP,Violante SN,Cross JR,Park-Min KH

Tue Jun 15 00:00:00 EDT 2021

An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma.

Nature communications

Xu B,Tian L,Chen J,Wang J,Ma R,Dong W,Li A,Zhang J,Antonio Chiocca E,Kaur B,Feng M,Caligiuri MA,Yu J

Fri Oct 08 00:00:00 EDT 2021

Evidence for additive and synergistic action of mammalian enhancers during cell fate determination.

eLife

Choi J,Lysakovskaia K,Stik G,Demel C,Söding J,Tian TV,Graf T,Cramer P

300-25 was used in In vitro experiments to investigate enhancer cooperation during transdifferentiation of human leukemia B-cells to macrophages.

Fri Mar 26 00:00:00 EDT 2021

Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages.

Cell death & disease

Wanke F,Gutbier S,Rümmelin A,Steinberg M,Hughes LD,Koenen M,Komuczki J,Regan-Komito D,Wagage S,Hesselmann J,Thoma R,Brugger D,Christopeit T,Wang H,Point F,Hallet R,Ghosh S,Rothlin CV,Patsch C,Geering B

Tue May 25 00:00:00 EDT 2021

Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance.

Cell reports

Li X,Zhang X,Xia J,Zhang L,Chen B,Lian G,Yun C,Yang J,Yan Y,Wang P,Wang X,Liu B,Liu H,Liang H,Pang Y,Wang X,Jiang C

Tue Aug 24 00:00:00 EDT 2021

Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.

Nature communications

Wang YC,Wang X,Yu J,Ma F,Li Z,Zhou Y,Zeng S,Ma X,Li YR,Neal A,Huang J,To A,Clarke N,Memarzadeh S,Pellegrini M,Yang L

Thu Jun 10 00:00:00 EDT 2021

Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.

Nature communications

Wang YC,Wang X,Yu J,Ma F,Li Z,Zhou Y,Zeng S,Ma X,Li YR,Neal A,Huang J,To A,Clarke N,Memarzadeh S,Pellegrini M,Yang L

Thu Jun 10 00:00:00 EDT 2021

Ionizing Radiation Curtails Immunosuppressive Effects From Cancer-Associated Fibroblasts on Dendritic Cells.

Frontiers in immunology

Berzaghi R,Tornaas S,Lode K,Hellevik T,Martinez-Zubiaurre I

300-25 was used in Sample Preparation (FC/FACS) to study immunomodulatory functions of cancer-associated fibroblasts (CAFs) during/after radiotherapy by studying the effects of ionizing radiation on CAF-mediated regulation of dendritic cells (DCs) to demonstrate hat CAFs interfere with DC immune functions and unveil that certain radiation regimens may reverse CAF-mediated immunosuppressive effects.

Thu Oct 14 00:00:00 EDT 2021

Regulatory B Cells (Bregs) Inhibit Osteoclastogenesis and Play a Potential Role in Ameliorating Ovariectomy-Induced Bone Loss.

Frontiers in immunology

Sapra L,Bhardwaj A,Mishra PK,Garg B,Verma B,Mishra GC,Srivastava RK

300-25 was used in Cell Culture to suggest that modulations in the percentage of Bregs population along with its reduced potential to produce IL-10 might further exacerbate the observed bone loss in ovx mice.

Thu Nov 04 00:00:00 EDT 2021

On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation.

Communications biology

Sopp JM,Peters SJ,Rowley TF,Oldham RJ,James S,Mockridge I,French RR,Turner A,Beers SA,Humphreys DP,Cragg MS

Thu Sep 02 00:00:00 EDT 2021

Identification of adipocytes as target cells for Leishmania infantum parasites.

Scientific reports

Schwing A,Pisani DF,Pomares C,Majoor A,Lacas-Gervais S,Jager J,Lemichez E,Marty P,Boyer L,Michel G

Thu Oct 28 00:00:00 EDT 2021

Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice.

Scientific reports

Sapra L,Dar HY,Bhardwaj A,Pandey A,Kumari S,Azam Z,Upmanyu V,Anwar A,Shukla P,Mishra PK,Saini C,Verma B,Srivastava RK

Tue Jan 19 00:00:00 EST 2021

Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu.

Communications biology

Hou XX,Wang XQ,Zhou WJ,Li DJ

Fri Apr 23 00:00:00 EDT 2021

Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.

Nature communications

Zhang L,Zhang K,Zhang J,Zhu J,Xi Q,Wang H,Zhang Z,Cheng Y,Yang G,Liu H,Guo X,Zhou D,Xue Z,Li Y,Zhang Q,Da Y,Liu L,Yin Z,Yao Z,Zhang R

300-25 was used in In vitro experiments to report a function of FATS in tumor development via regulation of tumor immunity.

Wed Jul 14 00:00:00 EDT 2021

Itaconate confers tolerance to late NLRP3 inflammasome activation.

Cell reports

Bambouskova M,Potuckova L,Paulenda T,Kerndl M,Mogilenko DA,Lizotte K,Swain A,Hayes S,Sheldon RD,Kim H,Kapadnis U,Ellis AE,Isaguirre C,Burdess S,Laha A,Amarasinghe GK,Chubukov V,Roddy TP,Diamond MS,Jones RG,Simons DM,Artyomov MN

Tue Mar 09 00:00:00 EST 2021

Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts.

Scientific reports

Murray JB,Mikhael C,Han G,de Faria LP,Rody WJ,Holliday LS

Wed Apr 28 00:00:00 EDT 2021

Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation.

Physiological reports

Sadvakassova G,Tiedemann K,Steer KJD,Mikolajewicz N,Stavnichuk M,In-Kyung Lee I,Sabirova Z,Schranzhofer M,Komarova SV

Mon Feb 01 00:00:00 EST 2021

Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles.

Journal of extracellular vesicles

Benet S,Gálvez C,Drobniewski F,Kontsevaya I,Arias L,Monguió-Tortajada M,Erkizia I,Urrea V,Ong RY,Luquin M,Dupont M,Chojnacki J,Dalmau J,Cardona P,Neyrolles O,Lugo-Villarino G,Vérollet C,Julián E,Furrer H,Günthard HF,Crocker PR,Tapia G,Borràs FE,Fellay J,McLaren PJ,Telenti A,Cardona PJ,Clotet B,Vilaplana C,Martinez-Picado J,Izquierdo-Useros N

Fri Jan 01 00:00:00 EST 2021

The neurorepellent, Slit2, prevents macrophage lipid loading by inhibiting CD36-dependent binding and internalization of oxidized low-density lipoprotein.

Scientific reports

Yusuf B,Mukovozov I,Patel S,Huang YW,Liu GY,Reddy EC,Skrtic M,Glogauer M,Robinson LA

Thu Feb 11 00:00:00 EST 2021

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.

Nature communications

Velten L,Story BA,Hernández-Malmierca P,Raffel S,Leonce DR,Milbank J,Paulsen M,Demir A,Szu-Tu C,Frömel R,Lutz C,Nowak D,Jann JC,Pabst C,Boch T,Hofmann WK,Müller-Tidow C,Trumpp A,Haas S,Steinmetz LM

Mon Mar 01 00:00:00 EST 2021

Regulatory protein HilD stimulates Salmonella Typhimurium invasiveness by promoting smooth swimming via the methyl-accepting chemotaxis protein McpC.

Nature communications

Cooper KG,Chong A,Kari L,Jeffrey B,Starr T,Martens C,McClurg M,Posada VR,Laughlin RC,Whitfield-Cargile C,Garry Adams L,Bryan LK,Little SV,Krath M,Lawhon SD,Steele-Mortimer O

Wed Jan 13 00:00:00 EST 2021

B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction.

Cell death & disease

Oh Y,Park R,Kim SY,Park SH,Jo S,Kim TH,Ji JD

Wed Oct 20 00:00:00 EDT 2021

High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming.

Nature communications

Hu G,Su Y,Kang BH,Fan Z,Dong T,Brown DR,Cheah J,Wittrup KD,Chen J

Wed Feb 03 00:00:00 EST 2021

PD-1 Affects the Immunosuppressive Function of Group 2 Innate Lymphoid Cells in Human Non-Small Cell Lung Cancer.

Frontiers in immunology

Shen C,Liu C,Zhang Z,Ping Y,Shao J,Tian Y,Yu W,Qin G,Liu S,Wang L,Zhang Y

300-25 was used in Sample Preparation (FC/FACS) to show that ILC2s are enriched in NSCLC patients and upregulate PD-1 expression.

Mon Oct 25 00:00:00 EDT 2021

Preclinical efficacy and toxicity studies of a highly specific chimeric anti-CD47 antibody.

FEBS open bio

Xu Z,Gao J,Yao J,Yang T,Wang D,Dai C,Ding Y

Mon Mar 01 00:00:00 EST 2021

An epigenetic GPI anchor defect impairs TLR4 signaling in the B cell transdifferentiation model for primary human monocytes BLaER1.

Scientific reports

Wegner J,Zillinger T,Schlee-Guimaraes TM,Bartok E,Schlee M

Thu Jul 22 00:00:00 EDT 2021

Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10.

Scientific reports

Wang X,Negrou E,Maloney MT,Bondar VV,Andrews SV,Montalban M,Llapashtica C,Maciuca R,Nguyen H,Solanoy H,Arguello A,Przybyla L,Moerke NJ,Huntwork-Rodriguez S,Henry AG

Fri Jun 18 00:00:00 EDT 2021

Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation.

Science immunology

Niyonzima N,Rahman J,Kunz N,West EE,Freiwald T,Desai JV,Merle NS,Gidon A,Sporsheim B,Lionakis MS,Evensen K,Lindberg B,Skagen K,Skjelland M,Singh P,Haug M,Ruseva MM,Kolev M,Bibby J,Marshall O,O'Brien B,Deeks N,Afzali B,Clark RJ,Woodruff TM,Pryor M,Yang ZH,Remaley AT,Mollnes TE,Hewitt SM,Yan B,Kazemian M,Kiss MG,Binder CJ,Halvorsen B,Espevik T,Kemper C

300-25 was used in Sample Preparation (Western Blotting) to suggest that the complosome is a contributor to the biologic processes underlying sterile inflammation and indicate that targeting this system could be beneficial in macrophage-dependent diseases, such as atherosclerosis.

Fri Dec 24 00:00:00 EST 2021

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.

Cell

Pasciuto E,Burton OT,Roca CP,Lagou V,Rajan WD,Theys T,Mancuso R,Tito RY,Kouser L,Callaerts-Vegh Z,de la Fuente AG,Prezzemolo T,Mascali LG,Brajic A,Whyte CE,Yshii L,Martinez-Muriana A,Naughton M,Young A,Moudra A,Lemaitre P,Poovathingal S,Raes J,De Strooper B,Fitzgerald DC,Dooley J,Liston A

Thu Aug 06 00:00:00 EDT 2020

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.

Cell

Cader MZ,de Almeida Rodrigues RP,West JA,Sewell GW,Md-Ibrahim MN,Reikine S,Sirago G,Unger LW,Iglesias-Romero AB,Ramshorn K,Haag LM,Saveljeva S,Ebel JF,Rosenstiel P,Kaneider NC,Lee JC,Lawley TD,Bradley A,Dougan G,Modis Y,Griffin JL,Kaser A

Thu Jan 23 00:00:00 EST 2020

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.

Cell

Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X

Thu Apr 16 00:00:00 EDT 2020

Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans.

Cell

Ha CWY,Martin A,Sepich-Poore GD,Shi B,Wang Y,Gouin K,Humphrey G,Sanders K,Ratnayake Y,Chan KSL,Hendrick G,Caldera JR,Arias C,Moskowitz JE,Ho Sui SJ,Yang S,Underhill D,Brady MJ,Knott S,Kaihara K,Steinbaugh MJ,Li H,McGovern DPB,Knight R,Fleshner P,Devkota S

Thu Oct 29 00:00:00 EDT 2020

Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.

Cell

Devalaraja S,To TKJ,Folkert IW,Natesan R,Alam MZ,Li M,Tada Y,Budagyan K,Dang MT,Zhai L,Lobel GP,Ciotti GE,Eisinger-Mathason TSK,Asangani IA,Weber K,Simon MC,Haldar M

300-25 was used in In vitro experiments to find that the TME induces tumor cells to produce retinoic acid (RA), which polarizes intratumoral monocyte differentiation toward TAMs and away from DCs via suppression of DC-promoting transcription factor Irf4.

Thu Mar 19 00:00:00 EDT 2020

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.

Cancer cell

Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J

Mon Jul 13 00:00:00 EDT 2020

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.

Cancer cell

Mon Jul 13 00:00:00 EDT 2020

Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer.

Signal transduction and targeted therapy

Zheng Y,Wu C,Yang J,Zhao Y,Jia H,Xue M,Xu D,Yang F,Fu D,Wang C,Hu B,Zhang Z,Li T,Yan S,Wang X,Nelson PJ,Bruns C,Qin L,Dong Q

Wed May 13 00:00:00 EDT 2020

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.

Cell metabolism

Yurdagul A,Subramanian M,Wang X,Crown SB,Ilkayeva OR,Darville L,Kolluru GK,Rymond CC,Gerlach BD,Zheng Z,Kuriakose G,Kevil CG,Koomen JM,Cleveland JL,Muoio DM,Tabas I

300-25 was used in Cell Culture to conclude that macrophage metabolism of AC-derived metabolites allows for optimal continual efferocytosis and resolution of injury.

Tue Mar 03 00:00:00 EST 2020

Macrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance.

Blood

Pinney JJ,Rivera-Escalera F,Chu CC,Whitehead HE,VanDerMeid KR,Nelson AM,Barbeau MC,Zent CS,Elliott MR

Thu Oct 29 00:00:00 EDT 2020

Bone marrow-derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis.

Blood

Xiao Y,van Halteren AGS,Lei X,Borst J,Steenwijk E,de Wit T,Grabowska J,Voogd R,Kemps P,Picarsic J,van den Bos C,Borst J

Thu Nov 05 00:00:00 EST 2020

Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin.

The Journal of clinical investigation

Andreev D,Liu M,Weidner D,Kachler K,Faas M,Grüneboom A,Schlötzer-Schrehardt U,Muñoz LE,Steffen U,Grötsch B,Killy B,Krönke G,Luebke AM,Niemeier A,Wehrhan F,Lang R,Schett G,Bozec A

Tue Sep 01 00:00:00 EDT 2020

Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer.

The Journal of clinical investigation

Liu M,Tong Z,Ding C,Luo F,Wu S,Wu C,Albeituni S,He L,Hu X,Tieri D,Rouchka EC,Hamada M,Takahashi S,Gibb AA,Kloecker G,Zhang HG,Bousamra M,Hill BG,Zhang X,Yan J

Wed Apr 01 00:00:00 EDT 2020

Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer.

The Journal of clinical investigation

Liu M,Tong Z,Ding C,Luo F,Wu S,Wu C,Albeituni S,He L,Hu X,Tieri D,Rouchka EC,Hamada M,Takahashi S,Gibb AA,Kloecker G,Zhang HG,Bousamra M,Hill BG,Zhang X,Yan J

Wed Apr 01 00:00:00 EDT 2020

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.

Neuron

Nugent AA,Lin K,van Lengerich B,Lianoglou S,Przybyla L,Davis SS,Llapashtica C,Wang J,Kim DJ,Xia D,Lucas A,Baskaran S,Haddick PCG,Lenser M,Earr TK,Shi J,Dugas JC,Andreone BJ,Logan T,Solanoy HO,Chen H,Srivastava A,Poda SB,Sanchez PE,Watts RJ,Sandmann T,Astarita G,Lewcock JW,Monroe KM,Di Paolo G

Wed Mar 04 00:00:00 EST 2020

Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9.

The Journal of experimental medicine

Freund EC,Lock JY,Oh J,Maculins T,Delamarre L,Bohlen CJ,Haley B,Murthy A

Mon Jul 06 00:00:00 EDT 2020

Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE.

The Journal of experimental medicine

Liu T,Zhu B,Liu Y,Zhang X,Yin J,Li X,Jiang L,Hodges AP,Rosenthal SB,Zhou L,Yancey J,McQuade A,Blurton-Jones M,Tanzi RE,Huang TY,Xu H

Mon Dec 07 00:00:00 EST 2020

Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway.

EMBO molecular medicine

Wilcz-Villega E,Carter E,Ironside A,Xu R,Mataloni I,Holdsworth J,Jones W,Moreno Béjar R,Uhlik L,Bentham RB,Godinho SA,Dalli J,Grose R,Szabadkai G,Jones L,Hodivala-Dilke K,Bianchi K

Fri Feb 07 00:00:00 EST 2020

Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease.

Proceedings of the National Academy of Sciences of the United States of America

Preciado-Llanes L,Aulicino A,Canals R,Moynihan PJ,Zhu X,Jambo N,Nyirenda TS,Kadwala I,Sousa Gerós A,Owen SV,Jambo KC,Kumwenda B,Veerapen N,Besra GS,Gordon MA,Hinton JCD,Napolitani G,Salio M,Simmons A

Tue Aug 25 00:00:00 EDT 2020

Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells.

Science signaling

Gómez V,Eykyn TR,Mustapha R,Flores-Borja F,Male V,Barber PR,Patsialou A,Green R,Panagaki F,Li CW,Fruhwirth GO,Ros S,Brindle KM,Ng T

Tue Oct 06 00:00:00 EDT 2020

KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression.

British journal of cancer

Gilardini Montani MS,Falcinelli L,Santarelli R,Granato M,Romeo MA,Cecere N,Gonnella R,D'Orazi G,Faggioni A,Cirone M

300-25 was used in Cell Culture to suggest that manipulation of unfolded protein response (UPR) could be exploited to prevent or improve the treatment of KSHV-associated malignancies.

Wed Jul 01 00:00:00 EDT 2020

Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors.

mAbs

Hatterer E,Chauchet X,Richard F,Barba L,Moine V,Chatel L,Broyer L,Pontini G,Bautzova T,Juan F,Calloud S,Bosson N,Charreton M,Masternak K,Buatois V,Shang L

300-25 was used in Cell Culture to show that MSLN targeted by bispecific antibodies (bsAbs)optimized ADCC activity by augmenting FcγR-IIIA activation and enhanced ADCP via a more efficient blockade of the CD47/SIRPα axis.

Fri Feb 12 00:00:00 EST 2021

Regulatory network mediated by RBP-J/NFATc1-miR182 controls inflammatory bone resorption.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Inoue K,Hu X,Zhao B

Sat Feb 01 00:00:00 EST 2020

IgA Triggers Cell Death of Neutrophils When Primed by Inflammatory Mediators.

Journal of immunology (Baltimore, Md. : 1950)

Wehrli M,Schneider C,Cortinas-Elizondo F,Verschoor D,Frias Boligan K,Adams OJ,Hlushchuk R,Engelmann C,Daudel F,Villiger PM,Seibold F,Yawalkar N,Vonarburg C,Miescher S,Lötscher M,Kaufmann T,Münz C,Mueller C,Djonov V,Simon HU,von Gunten S

Sun Nov 15 00:00:00 EST 2020

Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid.

Journal of immunology (Baltimore, Md. : 1950)

Brouwers H,Jónasdóttir HS,Kuipers ME,Kwekkeboom JC,Auger JL,Gonzalez-Torres M,López-Vicario C,Clària J,Freysdottir J,Hardardottir I,Garrido-Mesa J,Norling LV,Perretti M,Huizinga TWJ,Kloppenburg M,Toes REM,Binstadt B,Giera M,Ioan-Facsinay A

Sun Nov 15 00:00:00 EST 2020

IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network.

Journal of immunology (Baltimore, Md. : 1950)

Sun L,Girnary M,Wang L,Jiao Y,Zeng E,Mercer K,Zhang J,Marchesan JT,Yu N,Moss K,Lei YL,Offenbacher S,Zhang S

Wed Apr 15 00:00:00 EDT 2020

Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.

Journal of immunology (Baltimore, Md. : 1950)

Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D

Thu Oct 15 00:00:00 EDT 2020

Immune Complex-Driven Generation of Human Macrophages with Anti-Inflammatory and Growth-Promoting Activity.

Journal of immunology (Baltimore, Md. : 1950)

Dalby E,Christensen SM,Wang J,Hamidzadeh K,Chandrasekaran P,Hughitt VK,Tafuri WL,Arantes RME,Rodrigues IA,Herbst R,El-Sayed NM,Sims GP,Mosser DM

Wed Jul 01 00:00:00 EDT 2020

Siglec-15 on Osteoclasts Is Crucial for Bone Erosion in Serum-Transfer Arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Korn MA,Schmitt H,Angermüller S,Chambers D,Seeling M,Lux UT,Brey S,Royzman D,Brückner C,Popp V,Percivalle E,Bäuerle T,Zinser E,Winkler TH,Steinkasserer A,Nimmerjahn F,Nitschke L

Sun Nov 15 00:00:00 EST 2020

LncRNA-mRNA expression profiles and functional networks in osteoclast differentiation.

Journal of cellular and molecular medicine

Liu W,Li Z,Cai Z,Xie Z,Li J,Li M,Cen S,Tang S,Zheng G,Ye G,Su H,Wang S,Wang P,Shen H,Wu Y

Tue Sep 01 00:00:00 EDT 2020

LncRNA-mRNA expression profiles and functional networks in osteoclast differentiation.

Journal of cellular and molecular medicine

Liu W,Li Z,Cai Z,Xie Z,Li J,Li M,Cen S,Tang S,Zheng G,Ye G,Su H,Wang S,Wang P,Shen H,Wu Y

Tue Sep 01 00:00:00 EDT 2020

Osteoidosis leads to altered differentiation and function of osteoclasts.

Journal of cellular and molecular medicine

Grünherz L,Prein C,Winkler T,Kirsch M,Hopfner U,Streichert T,Clausen-Schaumann H,Zustin J,Kirchhof K,Morlock MM,Machens HG,Schilling AF

Fri May 01 00:00:00 EDT 2020

Lentiviral gene therapy rescues p47^phox chronic granulomatous disease and the ability to fight Salmonella infection in mice.

Gene therapy

Schejtman A,Aragão-Filho WC,Clare S,Zinicola M,Weisser M,Burns SO,Booth C,Gaspar HB,Thomas DC,Condino-Neto A,Thrasher AJ,Santilli G

Tue Sep 01 00:00:00 EDT 2020

Small extracellular vesicles derived from human MSCs prevent allergic airway inflammation via immunomodulation on pulmonary macrophages.

Cell death & disease

Fang SB,Zhang HY,Meng XC,Wang C,He BX,Peng YQ,Xu ZB,Fan XL,Wu ZJ,Wu ZC,Zheng SG,Fu QL

Mon Jun 01 00:00:00 EDT 2020

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis.

Nature communications

Montero-Melendez T,Nagano A,Chelala C,Filer A,Buckley CD,Perretti M

Thu Feb 06 00:00:00 EST 2020

Redox Regulator GLRX Is Associated With Tumor Immunity in Glioma.

Frontiers in immunology

Chang Y,Li G,Zhai Y,Huang L,Feng Y,Wang D,Zhang W,Hu H

300-25 was used in Cell Culture to investigate glutaredoxin regulation of glioma.

Mon Jun 21 00:00:00 EDT 2021

Glycogen metabolism regulates macrophage-mediated acute inflammatory responses.

Nature communications

Ma J,Wei K,Liu J,Tang K,Zhang H,Zhu L,Chen J,Li F,Xu P,Chen J,Liu J,Fang H,Tang L,Wang D,Zeng L,Sun W,Xie J,Liu Y,Huang B

Tue Apr 14 00:00:00 EDT 2020

Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells.

Theranostics

Miao L,Qi J,Zhao Q,Wu QN,Wei DL,Wei XL,Liu J,Chen J,Zeng ZL,Ju HQ,Luo HY,Xu RH

300-25 was used in In vitro experiments to unveil a novel function of STING to activate the IL6R-JAK-IL24 pathway in macrophages.

Wed Apr 21 00:00:00 EDT 2021

A versatile and customizable low-cost 3D-printed open standard for microscopic imaging.

Nature communications

Diederich B,Lachmann R,Carlstedt S,Marsikova B,Wang H,Uwurukundo X,Mosig AS,Heintzmann R

Wed Nov 25 00:00:00 EST 2020

Interactions of Monocytes, HIV, and ART Identified by an Innovative scRNAseq Pipeline: Pathways to Reservoirs and HIV-Associated Comorbidities.

mBio

León-Rivera R,Morsey B,Niu M,Fox HS,Berman JW

300-25 was used in Cell Culture to develop an innovative single cell RNA sequencing (scRNAseq) pipeline that detects HIV and host transcripts simultaneously, enabling us to examine differences between HIV+ and exposed cells (HIVexp) mature monocytes.

Tue Jul 28 00:00:00 EDT 2020

Accumulation of synovial fluid CD19⁺CD24^hiCD27⁺ B cells was associated with bone destruction in rheumatoid arthritis.

Scientific reports

Guo X,Xu T,Zheng J,Cui X,Li M,Wang K,Su M,Zhang H,Zheng K,Sun C,Song S,Liu H

Tue Sep 01 00:00:00 EDT 2020

Multiparametric Profiling of Engineered Nanomaterials: Unmasking the Surface Coating Effect.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Gallud A,Delaval M,Kinaret P,Marwah VS,Fortino V,Ytterberg J,Zubarev R,Skoog T,Kere J,Correia M,Loeschner K,Al-Ahmady Z,Kostarelos K,Ruiz J,Astruc D,Monopoli M,Handy R,Moya S,Savolainen K,Alenius H,Greco D,Fadeel B

Sun Nov 01 00:00:00 EDT 2020

Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.

Molecular systems biology

Morshed N,Ralvenius WT,Nott A,Watson LA,Rodriguez FH,Akay LA,Joughin BA,Pao PC,Penney J,LaRocque L,Mastroeni D,Tsai LH,White FM

Tue Dec 01 00:00:00 EST 2020

Distinct macrophage phenotypes skewed by local granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) are associated with tissue destruction and intimal hyperplasia in giant cell arteritis.

Clinical & translational immunology

Jiemy WF,van Sleen Y,van der Geest KS,Ten Berge HA,Abdulahad WH,Sandovici M,Boots AM,Heeringa P,Brouwer E

Sat Apr 16 00:00:00 EDT 2022

The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans.

Nature communications

Agarwal S,Vierbuchen T,Ghosh S,Chan J,Jiang Z,Kandasamy RK,Ricci E,Fitzgerald KA

Fri Dec 11 00:00:00 EST 2020

Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution.

Cell reports

Jordan PM,Gerstmeier J,Pace S,Bilancia R,Rao Z,Börner F,Miek L,Gutiérrez-Gutiérrez Ó,Arakandy V,Rossi A,Ialenti A,González-Estévez C,Löffler B,Tuchscherr L,Serhan CN,Werz O

300-25 was used in In vitro experiments to investigate the role of α-hemolysin from Staphylococcus aureus in the activation of specialized pro-resolving mediators.

Tue Oct 13 00:00:00 EDT 2020

Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts.

Bio-protocol

Chen IP

300-25 was used in Cell Culture to study efficient differentiation of hiPSCs into osteoclasts using a three-stage protocol which does not require a co-culture system; induces EBs into mesoderm differentiation in a homogenous manner; uses less cytokines for differentiation; requires only a short time for osteoclast maturation and produces sufficient numbers of osteoclasts for subsequent molecular analyses.

Sun Dec 20 00:00:00 EST 2020

RPTPε promotes M2-polarized macrophage migration through ROCK2 signaling and podosome formation.

Journal of cell science

Lapointe F,Turcotte S,Roy J,Bissonnette E,Rola-Pleszczynski M,Stankova J

300-25 was used in Cell Culture to show that differentiation and polarization of monocytes into M2-polarized hMDMs modulates the expression of PTPε isoforms and RPTPε is involved in podosome distribution, ROCK2 activation and migration in response to LTD4.

Tue Jan 21 00:00:00 EST 2020

Vorinostat in the acute neuroinflammatory form of X-linked adrenoleukodystrophy.

Annals of clinical and translational neurology

Zierfuss B,Weinhofer I,Kühl JS,Köhler W,Bley A,Zauner K,Binder J,Martinović K,Seiser C,Hertzberg C,Kemp S,Egger G,Leitner G,Bauer J,Wiesinger C,Kunze M,Forss-Petter S,Berger J

Fri May 01 00:00:00 EDT 2020

SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling.

Nature communications

Bhosle VK,Mukherjee T,Huang YW,Patel S,Pang BWF,Liu GY,Glogauer M,Wu JY,Philpott DJ,Grinstein S,Robinson LA

Mon Aug 17 00:00:00 EDT 2020

Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages.

eLife

Dupont M,Souriant S,Balboa L,Vu Manh TP,Pingris K,Rousset S,Cougoule C,Rombouts Y,Poincloux R,Ben Neji M,Allers C,Kaushal D,Kuroda MJ,Benet S,Martinez-Picado J,Izquierdo-Useros N,Sasiain MDC,Maridonneau-Parini I,Neyrolles O,Vérollet C,Lugo-Villarino G

300-25 was used in Cell Culture to uncover a deleterious role for Siglec-1 in TB-HIV-1 co-infection and open new avenues to understand TNT biology.

Mon Mar 30 00:00:00 EDT 2020

Establishment and validation of an in vitro co-culture model for oral cell lines using human PBMC-derived osteoclasts, osteoblasts, fibroblasts and keratinocytes.

Scientific reports

Steller D,Scheibert A,Sturmheit T,Hakim SG

Thu Oct 08 00:00:00 EDT 2020

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis.

Nature communications

Herster F,Bittner Z,Archer NK,Dickhöfer S,Eisel D,Eigenbrod T,Knorpp T,Schneiderhan-Marra N,Löffler MW,Kalbacher H,Vierbuchen T,Heine H,Miller LS,Hartl D,Freund L,Schäkel K,Heister M,Ghoreschi K,Weber ANR

Wed Jan 08 00:00:00 EST 2020

SMAC mimetics induce autophagy-dependent apoptosis of HIV-1-infected macrophages.

Cell death & disease

Campbell GR,To RK,Zhang G,Spector SA

Mon Jul 27 00:00:00 EDT 2020

Novel elvitegravir nanoformulation for drug delivery across the blood-brain barrier to achieve HIV-1 suppression in the CNS macrophages.

Scientific reports

Gong Y,Chowdhury P,Nagesh PKB,Rahman MA,Zhi K,Yallapu MM,Kumar S

Mon Mar 02 00:00:00 EST 2020

Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway.

Scientific reports

Krotova K,Khodayari N,Oshins R,Aslanidi G,Brantly ML

Mon Sep 28 00:00:00 EDT 2020

IgA subclasses have different effector functions associated with distinct glycosylation profiles.

Nature communications

Steffen U,Koeleman CA,Sokolova MV,Bang H,Kleyer A,Rech J,Unterweger H,Schicht M,Garreis F,Hahn J,Andes FT,Hartmann F,Hahn M,Mahajan A,Paulsen F,Hoffmann M,Lochnit G,Muñoz LE,Wuhrer M,Falck D,Herrmann M,Schett G

Wed Jan 08 00:00:00 EST 2020

Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.

Cell

Georgouli M,Herraiz C,Crosas-Molist E,Fanshawe B,Maiques O,Perdrix A,Pandya P,Rodriguez-Hernandez I,Ilieva KM,Cantelli G,Karagiannis P,Mele S,Lam H,Josephs DH,Matias-Guiu X,Marti RM,Nestle FO,Orgaz JL,Malanchi I,Fruhwirth GO,Karagiannis SN,Sanz-Moreno V

Thu Feb 07 00:00:00 EST 2019

The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.

Immunity

Kusnadi A,Park SH,Yuan R,Pannellini T,Giannopoulou E,Oliver D,Lu T,Park-Min KH,Ivashkiv LB

Tue Aug 20 00:00:00 EDT 2019

Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.

Immunity

Castro-Dopico T,Dennison TW,Ferdinand JR,Mathews RJ,Fleming A,Clift D,Stewart BJ,Jing C,Strongili K,Labzin LI,Monk EJM,Saeb-Parsy K,Bryant CE,Clare S,Parkes M,Clatworthy MR

Tue Apr 16 00:00:00 EDT 2019

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages.

Immunity

Schulthess J,Pandey S,Capitani M,Rue-Albrecht KC,Arnold I,Franchini F,Chomka A,Ilott NE,Johnston DGW,Pires E,McCullagh J,Sansom SN,Arancibia-Cárcamo CV,Uhlig HH,Powrie F

Tue Feb 19 00:00:00 EST 2019

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells.

Blood

Edwards DK,Watanabe-Smith K,Rofelty A,Damnernsawad A,Laderas T,Lamble A,Lind EF,Kaempf A,Mori M,Rosenberg M,d'Almeida A,Long N,Agarwal A,Sweeney DT,Loriaux M,McWeeney SK,Tyner JW

Thu Feb 07 00:00:00 EST 2019

Low-dose chidamide restores immune tolerance in ITP in mice and humans.

Blood

Zhao HY,Ma YH,Li DQ,Sun T,Li LZ,Li P,Liu XG,Zhou H,Hou Y,Liu Y,Han PP,Zhao YJ,Jing FM,Peng J,Hou M

Thu Feb 14 00:00:00 EST 2019

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.

The Journal of clinical investigation

Chan LC,Li CW,Xia W,Hsu JM,Lee HH,Cha JH,Wang HL,Yang WH,Yen EY,Chang WC,Zha Z,Lim SO,Lai YJ,Liu C,Liu J,Dong Q,Yang Y,Sun L,Wei Y,Nie L,Hsu JL,Li H,Ye Q,Hassan MM,Amin HM,Kaseb AO,Lin X,Wang SC,Hung MC

Mon Jul 15 00:00:00 EDT 2019

Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade.

Science translational medicine

Shekarian T,Sivado E,Jallas AC,Depil S,Kielbassa J,Janoueix-Lerosey I,Hutter G,Goutagny N,Bergeron C,Viari A,Valsesia-Wittmann S,Caux C,Marabelle A

300-25 was used in Sample Preparation (FC/FACS) to study whether anti-infectious disease vaccines could be used as a commercially available source of immunostimulatory agents for cancer immunotherapy.

Wed Oct 23 00:00:00 EDT 2019

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.

Neuron

Hasselmann J,Coburn MA,England W,Figueroa Velez DX,Kiani Shabestari S,Tu CH,McQuade A,Kolahdouzan M,Echeverria K,Claes C,Nakayama T,Azevedo R,Coufal NG,Han CZ,Cummings BJ,Davtyan H,Glass CK,Healy LM,Gandhi SP,Spitale RC,Blurton-Jones M

Wed Sep 25 00:00:00 EDT 2019

Streptococcus pyogenes evades adaptive immunity through specific IgG glycan hydrolysis.

The Journal of experimental medicine

Naegeli A,Bratanis E,Karlsson C,Shannon O,Kalluru R,Linder A,Malmström J,Collin M

Mon Jul 01 00:00:00 EDT 2019

A major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis.

The Journal of experimental medicine

Amaral EP,Costa DL,Namasivayam S,Riteau N,Kamenyeva O,Mittereder L,Mayer-Barber KD,Andrade BB,Sher A

Mon Mar 04 00:00:00 EST 2019

Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation.

Proceedings of the National Academy of Sciences of the United States of America

Davis MA,Fairgrieve MR,Den Hartigh A,Yakovenko O,Duvvuri B,Lood C,Thomas WE,Fink SL,Gale M

Tue Mar 12 00:00:00 EDT 2019

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.

Cell death and differentiation

Sarhan J,Liu BC,Muendlein HI,Weindel CG,Smirnova I,Tang AY,Ilyukha V,Sorokin M,Buzdin A,Fitzgerald KA,Poltorak A

Tue Jan 01 00:00:00 EST 2019

Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages.

British journal of cancer

Chen Q,Wang J,Zhang Q,Zhang J,Lou Y,Yang J,Chen Y,Wei T,Zhang J,Fu Q,Ye M,Zhang X,Dang X,Liang T,Bai X

Tue Oct 01 00:00:00 EDT 2019

Mesenchymal Stromal Cell-Seeded Biomimetic Scaffolds as a Factory of Soluble RANKL in Rankl-Deficient Osteopetrosis.

Stem cells translational medicine

Menale C,Campodoni E,Palagano E,Mantero S,Erreni M,Inforzato A,Fontana E,Schena F,Van't Hof R,Sandri M,Tampieri A,Villa A,Sobacchi C

Tue Jan 01 00:00:00 EST 2019

Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor-conditioned macrophages.

European journal of immunology

Maeda A,Digifico E,Andon FT,Mantovani A,Allavena P

Wed May 01 00:00:00 EDT 2019

A Human Gain-of-Function STING Mutation Causes Immunodeficiency and Gammaherpesvirus-Induced Pulmonary Fibrosis in Mice.

Journal of virology

Bennion BG,Ingle H,Ai TL,Miner CA,Platt DJ,Smith AM,Baldridge MT,Miner JJ

300-25 was used in Cell Culture to investigate STING N153S knock-in mice inflammatory response and pulmonary fibrosis.

Fri Feb 15 00:00:00 EST 2019

The mannose 6-phosphate/insulin-like growth factor 2 receptor mediates plasminogen-induced efferocytosis.

Journal of leukocyte biology

Ohradanova-Repic A,Machacek C,Donner C,Mühlgrabner V,Petrovčíková E,Zahradníková A,Vičíková K,Hořejší V,Stockinger H,Leksa V

Fri Mar 01 00:00:00 EST 2019

Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts.

Journal of immunology (Baltimore, Md. : 1950)

Krishnamurthy A,Ytterberg AJ,Sun M,Sakuraba K,Steen J,Joshua V,Tarasova NK,Malmström V,Wähämaa H,Réthi B,Catrina AI

Sat Jun 01 00:00:00 EDT 2019

Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.

Journal of immunology (Baltimore, Md. : 1950)

Stephenson S,Care MA,Fan I,Zougman A,Westhead DR,Doody GM,Tooze RM

Fri Feb 15 00:00:00 EST 2019

Monocyte/Macrophage Abnormalities Specific to Rheumatoid Arthritis Are Linked to miR-155 and Are Differentially Modulated by Different TNF Inhibitors.

Journal of immunology (Baltimore, Md. : 1950)

Paoletti A,Rohmer J,Ly B,Pascaud J,Rivière E,Seror R,Le Goff B,Nocturne G,Mariette X

Tue Oct 01 00:00:00 EDT 2019

Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer.

Journal of immunology (Baltimore, Md. : 1950)

Leko V,McDuffie LA,Zheng Z,Gartner JJ,Prickett TD,Apolo AB,Agarwal PK,Rosenberg SA,Lu YC

Sat Jun 15 00:00:00 EDT 2019

Intra- and Extracellular Degradation of Neutrophil Extracellular Traps by Macrophages and Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950)

Lazzaretto B,Fadeel B

Tue Oct 15 00:00:00 EDT 2019

Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages.

Nature communications

Bencheikh L,Diop MK,Rivière J,Imanci A,Pierron G,Souquere S,Naimo A,Morabito M,Dussiot M,De Leeuw F,Lobry C,Solary E,Droin N

Fri Apr 26 00:00:00 EDT 2019

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.

The Journal of biological chemistry

Tapia VS,Daniels MJD,Palazón-Riquelme P,Dewhurst M,Luheshi NM,Rivers-Auty J,Green J,Redondo-Castro E,Kaldis P,Lopez-Castejon G,Brough D

Fri May 24 00:00:00 EDT 2019

Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis.

Frontiers in immunology

Dong L,Wu J,Chen K,Xie J,Wang Y,Li D,Liu Y,Yin A,Zhao Y,Han Y,Zhou J,Zhang L,Chen Z,Zuo D

300-25 was used in Cell Culture to investigate the role of mannan-binding lectin on murine adjuvant-induced arthritis.

Wed Oct 28 00:00:00 EDT 2020

Fibroblast-Mediated Immunoregulation of Macrophage Function Is Maintained after Irradiation.

Cancers

Berzaghi R,Ahktar MA,Islam A,Pedersen BD,Hellevik T,Martinez-Zubiaurre I

300-25 was used in Sample Cell Culture to study whether ionizing radiation alters the cancer-associated fibroblast-mediated immunoregulatory effects on macrophages.

Fri May 17 00:00:00 EDT 2019

Immunoregulatory role of exosomes derived from differentiating mesenchymal stromal cells on inflammation and osteogenesis.

Journal of tissue engineering and regenerative medicine

Wei F,Li Z,Crawford R,Xiao Y,Zhou Y

300-25 was used in Cell Culture to suggest that exosomes derived from differentiating mesenchymal stem/stromal cells play a unique osteoimmunomodulatory role in the regulation of bone dynamics.

Fri Nov 01 00:00:00 EDT 2019

G-protein Gα₁₃ functions as a cytoskeletal and mitochondrial regulator to restrain osteoclast function.

Scientific reports

Nakano S,Inoue K,Xu C,Deng Z,Syrovatkina V,Vitone G,Zhao L,Huang XY,Zhao B

Tue Mar 12 00:00:00 EDT 2019

Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments.

The Journal of biological chemistry

Contreras-Baeza Y,Sandoval PY,Alarcón R,Galaz A,Cortés-Molina F,Alegría K,Baeza-Lehnert F,Arce-Molina R,Guequén A,Flores CA,San Martín A,Barros LF

Fri Dec 27 00:00:00 EST 2019

Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages.

Cell reports

Souriant S,Balboa L,Dupont M,Pingris K,Kviatcovsky D,Cougoule C,Lastrucci C,Bah A,Gasser R,Poincloux R,Raynaud-Messina B,Al Saati T,Inwentarz S,Poggi S,Moraña EJ,González-Montaner P,Corti M,Lagane B,Vergne I,Allers C,Kaushal D,Kuroda MJ,Sasiain MDC,Neyrolles O,Maridonneau-Parini I,Lugo-Villarino G,Vérollet C

300-25 was used in Cell Culture to reveal that TNTs facilitate viral transfer and amplification, thereby promoting TNT formation as a mechanism to be explored in TB/AIDS potential therapeutics.

Tue Mar 26 00:00:00 EDT 2019

Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis.

Scientific reports

Chen W,Zhu S,Wang Y,Li J,Qiang X,Zhao X,Yang H,D'Angelo J,Becker L,Wang P,Tracey KJ,Wang H

Thu Jan 17 00:00:00 EST 2019

Abnormal inhibition of osteoclastogenesis by mesenchymal stem cells through the miR-4284/CXCL5 axis in ankylosing spondylitis.

Cell death & disease

Liu W,Wang P,Xie Z,Wang S,Ma M,Li J,Li M,Cen S,Tang S,Zheng G,Ye G,Wu X,Wu Y,Shen H

Mon Feb 25 00:00:00 EST 2019

In-Depth Characterization of Monocyte-Derived Macrophages using a Mass Cytometry-Based Phagocytosis Assay.

Scientific reports

Schulz D,Severin Y,Zanotelli VRT,Bodenmiller B

Wed Feb 13 00:00:00 EST 2019

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation.

Frontiers in immunology

Lara-Reyna S,Scambler T,Holbrook J,Wong C,Jarosz-Griffiths HH,Martinon F,Savic S,Peckham D,McDermott MF

300-25 was used in Sample Preparation (FC/FACS) to investigate signalling pathways following cystic fibrosis transmembrane conductance regulator mutations.

Tue Oct 13 00:00:00 EDT 2020

Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1.

The Journal of biological chemistry

Pandey S,Li XX,Srivastava A,Baidya M,Kumari P,Dwivedi H,Chaturvedi M,Ghosh E,Woodruff TM,Shukla AK

Fri Jun 14 00:00:00 EDT 2019

Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death.

Cell death discovery

Klöditz K,Fadeel B

Tue Sep 29 00:00:00 EDT 2020

Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes.

Cell reports

Rodriguez RM,Suarez-Alvarez B,Lavín JL,Ascensión AM,Gonzalez M,Lozano JJ,Raneros AB,Bulnes PD,Vidal-Castiñeira JR,Huidobro C,Martin-Martin C,Sanz AB,Ruiz-Ortega M,Puig-Kröger A,Corbí AL,Araúzo-Bravo MJ,Aransay AM,Lopez-Larrea C

300-25 was used in Cell Culture to study how cells integrate the macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage CSF (GM-CSF) cytokines signals which are opposing regulators of the inflammatory program.

Tue Oct 22 00:00:00 EDT 2019

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia.

Stem cell reports

Konttinen H,Cabral-da-Silva MEC,Ohtonen S,Wojciechowski S,Shakirzyanova A,Caligola S,Giugno R,Ishchenko Y,Hernández D,Fazaludeen MF,Eamen S,Budia MG,Fagerlund I,Scoyni F,Korhonen P,Huber N,Haapasalo A,Hewitt AW,Vickers J,Smith GC,Oksanen M,Graff C,Kanninen KM,Lehtonen S,Propson N,Schwartz MP,Pébay A,Koistinaho J,Ooi L,Malm T

Tue Oct 08 00:00:00 EDT 2019

MiR-146a is over-expressed and controls IL-6 production in cystic fibrosis macrophages.

Scientific reports

Luly FR,Lévêque M,Licursi V,Cimino G,Martin-Chouly C,Théret N,Negri R,Cavinato L,Ascenzioni F,Del Porto P

Thu Nov 07 00:00:00 EST 2019

ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12.

Cell death & disease

Kloss L,Dollt C,Schledzewski K,Krewer A,Melchers S,Manta C,Sticht C,Torre C,Utikal J,Umansky V,Schmieder A

Mon Oct 07 00:00:00 EDT 2019

Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation.

Nature communications

Managò A,Audrito V,Mazzola F,Sorci L,Gaudino F,Gizzi K,Vitale N,Incarnato D,Minazzato G,Ianniello A,Varriale A,D'Auria S,Mengozzi G,Politano G,Oliviero S,Raffaelli N,Deaglio S

Wed Sep 11 00:00:00 EDT 2019

Immune-centric network of cytokines and cells in disease context identified by computational mining of PubMed.

Nature biotechnology

Kveler K,Starosvetsky E,Ziv-Kenet A,Kalugny Y,Gorelik Y,Shalev-Malul G,Aizenbud-Reshef N,Dubovik T,Briller M,Campbell J,Rieckmann JC,Asbeh N,Rimar D,Meissner F,Wiser J,Shen-Orr SS

Wed Aug 01 00:00:00 EDT 2018

Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

Cell

Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM

Thu Jan 25 00:00:00 EST 2018

Trophoblast-derived CXCL16 induces M2 macrophage polarization that in turn inactivates NK cells at the maternal-fetal interface.

Cellular & molecular immunology

Wang XQ,Zhou WJ,Hou XX,Fu Q,Li DJ

Sat Dec 01 00:00:00 EST 2018

Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity.

The Journal of clinical investigation

Chen HM,van der Touw W,Wang YS,Kang K,Mai S,Zhang J,Alsina-Beauchamp D,Duty JA,Mungamuri SK,Zhang B,Moran T,Flavell R,Aaronson S,Hu HM,Arase H,Ramanathan S,Flores R,Pan PY,Chen SH

Mon Dec 03 00:00:00 EST 2018

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.

Neuron

Lin YT,Seo J,Gao F,Feldman HM,Wen HL,Penney J,Cam HP,Gjoneska E,Raja WK,Cheng J,Rueda R,Kritskiy O,Abdurrob F,Peng Z,Milo B,Yu CJ,Elmsaouri S,Dey D,Ko T,Yankner BA,Tsai LH

Wed Jun 27 00:00:00 EDT 2018

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity.

Neuron

Bennett FC,Bennett ML,Yaqoob F,Mulinyawe SB,Grant GA,Hayden Gephart M,Plowey ED,Barres BA

Wed Jun 27 00:00:00 EDT 2018

Human monocytes and macrophages regulate immune tolerance via integrin αvβ8-mediated TGFβ activation.

The Journal of experimental medicine

Kelly A,Gunaltay S,McEntee CP,Shuttleworth EE,Smedley C,Houston SA,Fenton TM,Levison S,Mann ER,Travis MA

Mon Nov 05 00:00:00 EST 2018

A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.

Developmental cell

Böiers C,Richardson SE,Laycock E,Zriwil A,Turati VA,Brown J,Wray JP,Wang D,James C,Herrero J,Sitnicka E,Karlsson S,Smith AJH,Jacobsen SEW,Enver T

300-25 was used in Cell Culture to explore the link between embryonic B-myeloid fate restriction and ETV6-RUNX1 mutant acute B-lymphoblastic leukaemia development.

Mon Feb 05 00:00:00 EST 2018

Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation.

Bone research

Carey HA,Hildreth BE,Geisler JA,Nickel MC,Cabrera J,Ghosh S,Jiang Y,Yan J,Lee J,Makam S,Young NA,Valiente GR,Jarjour WN,Huang K,Rosol TJ,Toribio RE,Charles JF,Ostrowski MC,Sharma SM

Tue Sep 29 00:00:00 EDT 2020

Membrane-wrapped nanoparticles probe divergent roles of GM3 and phosphatidylserine in lipid-mediated viral entry pathways.

Proceedings of the National Academy of Sciences of the United States of America

Xu F,Bandara A,Akiyama H,Eshaghi B,Stelter D,Keyes T,Straub JE,Gummuluru S,Reinhard BM

Tue Sep 25 00:00:00 EDT 2018

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation.

EMBO reports

Palazón-Riquelme P,Worboys JD,Green J,Valera A,Martín-Sánchez F,Pellegrini C,Brough D,López-Castejón G

Mon Oct 01 00:00:00 EDT 2018

Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances.

Frontiers in immunology

Ohradanova-Repic A,Machacek C,Charvet C,Lager F,Le Roux D,Platzer R,Leksa V,Mitulovic G,Burkard TR,Zlabinger GJ,Fischer MB,Feuillet V,Renault G,Blüml S,Benko M,Suchanek M,Huppa JB,Matsuyama T,Cavaco-Paulo A,Bismuth G,Stockinger H

Fri Jun 14 00:00:00 EDT 2019

Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer.

Oncogene

Ireland L,Santos A,Campbell F,Figueiredo C,Hammond D,Ellies LG,Weyer-Czernilofsky U,Bogenrieder T,Schmid M,Mielgo A

Sun Apr 01 00:00:00 EDT 2018

X-linked inhibitor of apoptosis inhibition sensitizes acute myeloid leukemia cell response to TRAIL and chemotherapy through potentiated induction of proapoptotic machinery.

Molecular oncology

Zhou J,Lu X,Tan TZ,Chng WJ

Mon Jan 01 00:00:00 EST 2018

ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.

Journal of immunology (Baltimore, Md. : 1950)

Hecht I,Toporik A,Podojil JR,Vaknin I,Cojocaru G,Oren A,Aizman E,Liang SC,Leung L,Dicken Y,Novik A,Marbach-Bar N,Elmesmari A,Tange C,Gilmour A,McIntyre D,Kurowska-Stolarska M,McNamee K,Leitner J,Greenwald S,Dassa L,Levine Z,Steinberger P,Williams RO,Miller SD,McInnes IB,Neria E,Rotman G

Thu Mar 15 00:00:00 EDT 2018

Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors.

Journal of immunology (Baltimore, Md. : 1950)

Nissen SK,Pedersen JG,Helleberg M,Kjær K,Thavachelvam K,Obel N,Tolstrup M,Jakobsen MR,Mogensen TH

Tue May 15 00:00:00 EDT 2018

IL-1β Induces Pathologically Activated Osteoclasts Bearing Extremely High Levels of Resorbing Activity: A Possible Pathological Subpopulation of Osteoclasts, Accompanied by Suppressed Expression of Kindlin-3 and Talin-1.

Journal of immunology (Baltimore, Md. : 1950)

Shiratori T,Kyumoto-Nakamura Y,Kukita A,Uehara N,Zhang J,Koda K,Kamiya M,Badawy T,Tomoda E,Xu X,Yamaza T,Urano Y,Koyano K,Kukita T

Mon Jan 01 00:00:00 EST 2018

The PI3Kδ-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augments B Cell Depletion In Vivo.

Journal of immunology (Baltimore, Md. : 1950)

Palazzo A,Herter S,Grosmaire L,Jones R,Frey CR,Limani F,Bacac M,Umana P,Oldham RJ,Marshall MJE,Cox KL,Turaj AH,Cragg MS,Klein C,Carter MJ,Tannheimer S

Sun Apr 01 00:00:00 EDT 2018

Efficacy and Mechanism of Antitumor Activity of an Antibody Targeting Transferrin Receptor 1 in Mouse Models of Human Multiple Myeloma.

Journal of immunology (Baltimore, Md. : 1950)

Leoh LS,Kim YK,Candelaria PV,Martínez-Maza O,Daniels-Wells TR,Penichet ML

Tue May 15 00:00:00 EDT 2018

Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B.

Journal of immunology (Baltimore, Md. : 1950)

van der Touw W,Kang K,Luan Y,Ma G,Mai S,Qin L,Bian G,Zhang R,Mungamuri SK,Hu HM,Zhang CC,Aaronson SA,Feldmann M,Yang WC,Chen SH,Pan PY

Sat Sep 15 00:00:00 EDT 2018

BMP-2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte-to-macrophage differentiation.

Journal of cellular and molecular medicine

Pardali E,Makowski LM,Leffers M,Borgscheiper A,Waltenberger J

Thu Nov 01 00:00:00 EDT 2018

A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling.

ACS chemical biology

Koch PD,Miller HR,Yu G,Tallarico JA,Sorger PK,Wang Y,Feng Y,Thomas JR,Ross NT,Mitchison T

300-25 was used in In vitro experiments to study advancing IRF3 and NFkB pathway understanding and discovering probes for immunology research by screened a library of bioactive small molecules for activators and inhibitors of innate immune signaling through these pathways.

Fri Apr 20 00:00:00 EDT 2018

Characterizing replication kinetics and plaque production of type I feline infectious peritonitis virus in three feline cell lines.

Virology

O'Brien A,Mettelman RC,Volk A,André NM,Whittaker GR,Baker SC

300-25 was used in Cell Culture to characterize replication kinetics and plaque formation of a model type I strain FIPV Black in Fcwf-4 cells established at Cornell University (Fcwf-4 CU) to determine that the Fcwf-4 CU cells are morphologically distinct from feline bone marrow-derived macrophages and are less sensitive to exogenous type I interferon than Fcwf-4 cells purchased from ATCC.

Sat Dec 01 00:00:00 EST 2018

A correlative and quantitative imaging approach enabling characterization of primary cell-cell communication: Case of human CD4⁺ T cell-macrophage immunological synapses.

Scientific reports

Kasprowicz R,Rand E,O'Toole PJ,Signoret N

Tue May 22 00:00:00 EDT 2018

Bone protection by inhibition of microRNA-182.

Nature communications

Inoue K,Deng Z,Chen Y,Giannopoulou E,Xu R,Gong S,Greenblatt MB,Mangala LS,Lopez-Berestein G,Kirsch DG,Sood AK,Zhao L,Zhao B

Fri Oct 05 00:00:00 EDT 2018

Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt.

Scientific reports

Dang T,Liou GY

Wed May 16 00:00:00 EDT 2018

Angiogenic factor-driven inflammation promotes extravasation of human proangiogenic monocytes to tumours.

Nature communications

Sidibe A,Ropraz P,Jemelin S,Emre Y,Poittevin M,Pocard M,Bradfield PF,Imhof BA

Wed Jan 24 00:00:00 EST 2018

Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis.

Cell death & disease

Lee CJ,Moon SJ,Jeong JH,Lee S,Lee MH,Yoo SM,Lee HS,Kang HC,Lee JY,Lee WS,Lee HJ,Kim EK,Jhun JY,Cho ML,Min JK,Cho YY

Wed Mar 14 00:00:00 EDT 2018

Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis.

Cell death & disease

Lee CJ,Moon SJ,Jeong JH,Lee S,Lee MH,Yoo SM,Lee HS,Kang HC,Lee JY,Lee WS,Lee HJ,Kim EK,Jhun JY,Cho ML,Min JK,Cho YY

Wed Mar 14 00:00:00 EDT 2018

NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.

JCI insight

Barruet E,Morales BM,Cain CJ,Ton AN,Wentworth KL,Chan TV,Moody TA,Haks MC,Ottenhoff TH,Hellman J,Nakamura MC,Hsiao EC

300-25 was used in In vitro experiments to examine the potential link between bone morphogenetic proteins and inflammation in patients with fibrodysplasia ossificans progressiva.

Thu Nov 15 00:00:00 EST 2018

Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography.

Scientific reports

Silvola JMU,Li XG,Virta J,Marjamäki P,Liljenbäck H,Hytönen JP,Tarkia M,Saunavaara V,Hurme S,Palani S,Hakovirta H,Ylä-Herttuala S,Saukko P,Chen Q,Low PS,Knuuti J,Saraste A,Roivainen A

Tue Jun 26 00:00:00 EDT 2018

A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans.

Nature communications

Zhang G,deWeerd NA,Stifter SA,Liu L,Zhou B,Wang W,Zhou Y,Ying B,Hu X,Matthews AY,Ellis M,Triccas JA,Hertzog PJ,Britton WJ,Chen X,Feng CG

Mon Jan 08 00:00:00 EST 2018

Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1β production.

Cell death & disease

Tang AC,Rahavi SM,Fung SY,Lu HY,Yang H,Lim CJ,Reid GS,Turvey SE

Wed Feb 07 00:00:00 EST 2018

Effects of low molecular weight heparin on the polarization and cytokine profile of macrophages and T helper cells in vitro.

Scientific reports

Bruno V,Svensson-Arvelund J,Rubér M,Berg G,Piccione E,Jenmalm MC,Ernerudh J

Thu Mar 08 00:00:00 EST 2018

HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction.

Nature communications

Akiyama H,Miller CM,Ettinger CR,Belkina AC,Snyder-Cappione JE,Gummuluru S

Mon Aug 27 00:00:00 EDT 2018

Azithromycin promotes alternatively activated macrophage phenotype in systematic lupus erythematosus via PI3K/Akt signaling pathway.

Cell death & disease

Wang J,Xie L,Wang S,Lin J,Liang J,Xu J

Mon Oct 22 00:00:00 EDT 2018

Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication.

The Journal of biological chemistry

Campbell GR,Bruckman RS,Herns SD,Joshi S,Durden DL,Spector SA

Fri Apr 20 00:00:00 EDT 2018

A three-dimensional hybrid pacemaker electrode seamlessly integrates into engineered, functional human cardiac tissue in vitro.

Scientific reports

Weigel T,Schmitz T,Pfister T,Gaetzner S,Jannasch M,Al-Hijailan R,Schürlein S,Suliman S,Mustafa K,Hansmann J

Fri Sep 28 00:00:00 EDT 2018

The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration.

Cell death & disease

Dollt C,Michel J,Kloss L,Melchers S,Schledzewski K,Becker K,Sauer A,Krewer A,Koll F,Schmieder A

Wed Sep 19 00:00:00 EDT 2018

Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages.

EBioMedicine

Rhys HI,Dell'Accio F,Pitzalis C,Moore A,Norling LV,Perretti M

300-25 was used in Cell Culture to present new mechanistic evidence underpinning the anti-inflammatory and anti-arthritic properties of neutrophil microvesicles.

Thu Mar 01 00:00:00 EST 2018

Integrin CD11b activation drives anti-tumor innate immunity.

Nature communications

Schmid MC,Khan SQ,Kaneda MM,Pathria P,Shepard R,Louis TL,Anand S,Woo G,Leem C,Faridi MH,Geraghty T,Rajagopalan A,Gupta S,Ahmed M,Vazquez-Padron RI,Cheresh DA,Gupta V,Varner JA

Wed Dec 19 00:00:00 EST 2018

Integrin CD11b activation drives anti-tumor innate immunity.

Nature communications

Schmid MC,Khan SQ,Kaneda MM,Pathria P,Shepard R,Louis TL,Anand S,Woo G,Leem C,Faridi MH,Geraghty T,Rajagopalan A,Gupta S,Ahmed M,Vazquez-Padron RI,Cheresh DA,Gupta V,Varner JA

Wed Dec 19 00:00:00 EST 2018

Systematic RNA-interference in primary human monocyte-derived macrophages: A high-throughput platform to study foam cell formation.

Scientific reports

Domschke G,Linden F,Pawig L,Hafner A,Akhavanpoor M,Reymann J,Doesch AO,Erbel C,Weber C,Katus HA,Noels H,Erfle H,Gleissner CA,Runz H

Thu Jul 12 00:00:00 EDT 2018

Assessment of ATP8B1 Deficiency in Pediatric Patients With Cholestasis Using Peripheral Blood Monocyte-Derived Macrophages.

EBioMedicine

Hayashi H,Naoi S,Togawa T,Hirose Y,Kondou H,Hasegawa Y,Abukawa D,Sasaki M,Muroya K,Watanabe S,Nakano S,Minowa K,Inui A,Fukuda A,Kasahara M,Nagasaka H,Bessho K,Suzuki M,Kusuhara H

300-25 was used in Cell Culture to show that ATP8B1 deficiency caused incomplete polarization of HMDM into M2c and that phenotypic analysis of M2c helps to identify PFIC1 patients with no apparent disease-causing mutations in ATP8B1.

Mon Jan 01 00:00:00 EST 2018

Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.

Stem cell reports

Brownjohn PW,Smith J,Solanki R,Lohmann E,Houlden H,Hardy J,Dietmann S,Livesey FJ

Tue Apr 10 00:00:00 EDT 2018

oxLDL inhibits differentiation and functional activity of osteoclasts via scavenger receptor-A mediated autophagy and cathepsin K secretion.

Scientific reports

Dawodu D,Patecki M,Hegermann J,Dumler I,Haller H,Kiyan Y

Thu Aug 02 00:00:00 EDT 2018

Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.

Nature communications

Muliaditan T,Caron J,Okesola M,Opzoomer JW,Kosti P,Georgouli M,Gordon P,Lall S,Kuzeva DM,Pedro L,Shields JD,Gillett CE,Diebold SS,Sanz-Moreno V,Ng T,Hoste E,Arnold JN

Fri Jul 27 00:00:00 EDT 2018

Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.

Nature communications

Ackermann M,Kempf H,Hetzel M,Hesse C,Hashtchin AR,Brinkert K,Schott JW,Haake K,Kühnel MP,Glage S,Figueiredo C,Jonigk D,Sewald K,Schambach A,Wronski S,Moritz T,Martin U,Zweigerdt R,Munder A,Lachmann N

Fri Nov 30 00:00:00 EST 2018

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.

Nature communications

Mizoguchi F,Slowikowski K,Wei K,Marshall JL,Rao DA,Chang SK,Nguyen HN,Noss EH,Turner JD,Earp BE,Blazar PE,Wright J,Simmons BP,Donlin LT,Kalliolias GD,Goodman SM,Bykerk VP,Ivashkiv LB,Lederer JA,Hacohen N,Nigrovic PA,Filer A,Buckley CD,Raychaudhuri S,Brenner MB

Fri Feb 23 00:00:00 EST 2018

RNA-seq of macrophages of amoeboid or mesenchymal migratory phenotype due to specific structure of environment.

Scientific data

Čermák V,Gandalovičová A,Merta L,Fučíková J,Špíšek R,Rösel D,Brábek J

Tue Oct 02 00:00:00 EDT 2018

Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization.

Nature communications

Lee CC,Lin JC,Hwang WL,Kuo YJ,Chen HK,Tai SK,Lin CC,Yang MH

Fri Sep 14 00:00:00 EDT 2018

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.

Nature

Molgora M,Bonavita E,Ponzetta A,Riva F,Barbagallo M,Jaillon S,Popović B,Bernardini G,Magrini E,Gianni F,Zelenay S,Jonjić S,Santoni A,Garlanda C,Mantovani A

Thu Nov 02 00:00:00 EDT 2017

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.

Cell

Chen K,Liu J,Liu S,Xia M,Zhang X,Han D,Jiang Y,Wang C,Cao X

300-25 was used in Cell Culture to identify STAT1 methylation on K525 catalyzed by the methyltransferase SETD2 as an essential signaling event for IFNα-dependent antiviral immunity and indicates potential of SETD2 in controlling viral infections.

Thu Jul 27 00:00:00 EDT 2017

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

Cell

Gaidt MM,Ebert TS,Chauhan D,Ramshorn K,Pinci F,Zuber S,O'Duill F,Schmid-Burgk JL,Hoss F,Buhmann R,Wittmann G,Latz E,Subklewe M,Hornung V

Thu Nov 16 00:00:00 EST 2017

Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.

Cell

Berry MR,Mathews RJ,Ferdinand JR,Jing C,Loudon KW,Wlodek E,Dennison TW,Kuper C,Neuhofer W,Clatworthy MR

Thu Aug 24 00:00:00 EDT 2017

An Immune Atlas of Clear Cell Renal Cell Carcinoma.

Cell

Chevrier S,Levine JH,Zanotelli VRT,Silina K,Schulz D,Bacac M,Ries CH,Ailles L,Jewett MAS,Moch H,van den Broek M,Beisel C,Stadler MB,Gedye C,Reis B,Pe'er D,Bodenmiller B

Thu May 04 00:00:00 EDT 2017

Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF.

Immunity

Kang K,Park SH,Chen J,Qiao Y,Giannopoulou E,Berg K,Hanidu A,Li J,Nabozny G,Kang K,Park-Min KH,Ivashkiv LB

Tue Aug 15 00:00:00 EDT 2017

Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis.

Immunity

Murata K,Fang C,Terao C,Giannopoulou EG,Lee YJ,Lee MJ,Mun SH,Bae S,Qiao Y,Yuan R,Furu M,Ito H,Ohmura K,Matsuda S,Mimori T,Matsuda F,Park-Min KH,Ivashkiv LB

Tue Jul 18 00:00:00 EDT 2017

MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα.

The Journal of clinical investigation

Bae S,Lee MJ,Mun SH,Giannopoulou EG,Yong-Gonzalez V,Cross JR,Murata K,Giguère V,van der Meulen M,Park-Min KH

Fri Jun 30 00:00:00 EDT 2017

Macrophage-Dependent Cytoplasmic Transfer during Melanoma Invasion In Vivo.

Developmental cell

Roh-Johnson M,Shah AN,Stonick JA,Poudel KR,Kargl J,Yang GH,di Martino J,Hernandez RE,Gast CE,Zarour LR,Antoku S,Houghton AM,Bravo-Cordero JJ,Wong MH,Condeelis J,Moens CB

300-25 was used in Cell Culture to study and visualise tumour cells and their interactions with macrophages in zebrafish.

Mon Dec 04 00:00:00 EST 2017

Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network.

Cell systems

Martins AJ,Narayanan M,Prüstel T,Fixsen B,Park K,Gottschalk RA,Lu Y,Andrews-Pfannkoch C,Lau WW,Wendelsdorf KV,Tsang JS

300-25 was used in In vitro experiments to explore context-dependent noise propagation among genes in human macrophages.

Wed Apr 26 00:00:00 EDT 2017

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt.

Frontiers in cell and developmental biology

Tiedemann K,Le Nihouannen D,Fong JE,Hussein O,Barralet JE,Komarova SV

300-25 was used in Cell Culture to investigate TOR effects on osteoclast differentiation.

Tue Sep 29 00:00:00 EDT 2020

Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication.

Journal of immunology (Baltimore, Md. : 1950)

Wang J,Kang L,Song D,Liu L,Yang S,Ma L,Guo Z,Ding H,Wang H,Yang B

Sun Oct 01 00:00:00 EDT 2017

Complement Protein C1q Enhances Macrophage Foam Cell Survival and Efferocytosis.

Journal of immunology (Baltimore, Md. : 1950)

Pulanco MC,Cosman J,Ho MM,Huynh J,Fing K,Turcu J,Fraser DA

Sun Jan 01 00:00:00 EST 2017

Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 Macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Bellora F,Dondero A,Corrias MV,Casu B,Regis S,Caliendo F,Moretta A,Cazzola M,Elena C,Vinti L,Locatelli F,Bottino C,Castriconi R

Tue Aug 15 00:00:00 EDT 2017

The Role of Shed PrP^c in the Neuropathogenesis of HIV Infection.

Journal of immunology (Baltimore, Md. : 1950)

Megra BW,Eugenin EA,Berman JW

Sat Jul 01 00:00:00 EDT 2017

Tissue-Engineered Model of Human Osteolytic Bone Tumor.

Tissue engineering. Part C, Methods

Villasante A,Marturano-Kruik A,Robinson ST,Liu Z,Guo XE,Vunjak-Novakovic G

300-25 was used in Cell Culture to study a novel bioengineered model of Ewing's sarcoma (ES) that incorporates the osteolytic process which can be used to investigate how tumor cells invade bone.

Wed Feb 01 00:00:00 EST 2017

Participation of 3-O-sulfated heparan sulfates in the protection of macrophages by herpes simplex virus-1 glycoprotein D and cyclophilin B against apoptosis.

FEBS open bio

Delos M,Hellec C,Foulquier F,Carpentier M,Allain F,Denys A

Wed Feb 01 00:00:00 EST 2017

KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression.

Nature communications

Zhao H,Wang X,Yi P,Si Y,Tan P,He J,Yu S,Ren Y,Ma Y,Zhang J,Wang D,Wang F,Yu J

Fri Nov 10 00:00:00 EST 2017

DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation.

Nature communications

Kim HS,Nam ST,Mun SH,Lee SK,Kim HW,Park YH,Kim B,Won KJ,Kim HR,Park YM,Kim HS,Beaven MA,Kim YM,Choi WS

Wed Nov 15 00:00:00 EST 2017

Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.

Nature communications

Zuliani-Alvarez L,Marzeda AM,Deligne C,Schwenzer A,McCann FE,Marsden BD,Piccinini AM,Midwood KS

Fri Nov 17 00:00:00 EST 2017

RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages.

Scientific reports

Pujantell M,Riveira-Muñoz E,Badia R,Castellví M,Garcia-Vidal E,Sirera G,Puig T,Ramirez C,Clotet B,Esté JA,Ballana E

Tue Oct 17 00:00:00 EDT 2017

RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages.

Scientific reports

Pujantell M,Riveira-Muñoz E,Badia R,Castellví M,Garcia-Vidal E,Sirera G,Puig T,Ramirez C,Clotet B,Esté JA,Ballana E

Tue Oct 17 00:00:00 EDT 2017

Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells.

Nature communications

Lee PP,Lobato-Márquez D,Pramanik N,Sirianni A,Daza-Cajigal V,Rivers E,Cavazza A,Bouma G,Moulding D,Hultenby K,Westerberg LS,Hollinshead M,Lau YL,Burns SO,Mostowy S,Bajaj-Elliott M,Thrasher AJ

Fri Nov 17 00:00:00 EST 2017

Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages.

Nature communications

Rollins DA,Kharlyngdoh JB,Coppo M,Tharmalingam B,Mimouna S,Guo Z,Sacta MA,Pufall MA,Fisher RP,Hu X,Chinenov Y,Rogatsky I

Thu Nov 23 00:00:00 EST 2017

Tunneling nanotubes (TNT) mediate long-range gap junctional communication: Implications for HIV cell to cell spread.

Scientific reports

Okafo G,Prevedel L,Eugenin E

Thu Nov 30 00:00:00 EST 2017

Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs.

Nature communications

Niu Z,Shi Q,Zhang W,Shu Y,Yang N,Chen B,Wang Q,Zhao X,Chen J,Cheng N,Feng X,Hua Z,Ji J,Shen P

Tue Oct 03 00:00:00 EDT 2017

Classification of M1/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis.

Scientific reports

Bertani FR,Mozetic P,Fioramonti M,Iuliani M,Ribelli G,Pantano F,Santini D,Tonini G,Trombetta M,Businaro L,Selci S,Rainer A

Mon Aug 21 00:00:00 EDT 2017

Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia.

Nature communications

Krishnasamy K,Limbourg A,Kapanadze T,Gamrekelashvili J,Beger C,Häger C,Lozanovski VJ,Falk CS,Napp LC,Bauersachs J,Mack M,Haller H,Weber C,Adams RH,Limbourg FP

Mon Oct 16 00:00:00 EDT 2017

Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis.

Scientific reports

Lee CH,Bae SJ,Kim M

Tue Sep 19 00:00:00 EDT 2017

DNA methylation governs the dynamic regulation of inflammation by apoptotic cells during efferocytosis.

Scientific reports

Notley CA,Jordan CK,McGovern JL,Brown MA,Ehrenstein MR

Tue Feb 07 00:00:00 EST 2017

Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling.

The Journal of biological chemistry

Murakami A,Matsuda M,Harada Y,Hirata M

Fri May 12 00:00:00 EDT 2017

Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis.

Cell

Freeman SA,Goyette J,Furuya W,Woods EC,Bertozzi CR,Bergmeier W,Hinz B,van der Merwe PA,Das R,Grinstein S

Thu Jan 14 00:00:00 EST 2016

Human Monocytes Engage an Alternative Inflammasome Pathway.

Immunity

Gaidt MM,Ebert TS,Chauhan D,Schmidt T,Schmid-Burgk JL,Rapino F,Robertson AA,Cooper MA,Graf T,Hornung V

Tue Apr 19 00:00:00 EDT 2016

Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.

The Journal of experimental medicine

Quek L,Otto GW,Garnett C,Lhermitte L,Karamitros D,Stoilova B,Lau IJ,Doondeea J,Usukhbayar B,Kennedy A,Metzner M,Goardon N,Ivey A,Allen C,Gale R,Davies B,Sternberg A,Killick S,Hunter H,Cahalin P,Price A,Carr A,Griffiths M,Virgo P,Mackinnon S,Grimwade D,Freeman S,Russell N,Craddock C,Mead A,Peniket A,Porcher C,Vyas P

Mon Jul 25 00:00:00 EDT 2016

Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-β1.

Stem cells (Dayton, Ohio)

Barcellos-de-Souza P,Comito G,Pons-Segura C,Taddei ML,Gori V,Becherucci V,Bambi F,Margheri F,Laurenzana A,Del Rosso M,Chiarugi P

Sat Oct 01 00:00:00 EDT 2016

Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen.

Journal of immunology (Baltimore, Md. : 1950)

Machacek C,Supper V,Leksa V,Mitulovic G,Spittler A,Drbal K,Suchanek M,Ohradanova-Repic A,Stockinger H

Thu Sep 15 00:00:00 EDT 2016

MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes.

Journal of immunology (Baltimore, Md. : 1950)

Chen LT,Hu MM,Xu ZS,Liu Y,Shu HB

Fri Jul 01 00:00:00 EDT 2016

Transmembrane TNF-α Reverse Signaling Inhibits Lipopolysaccharide-Induced Proinflammatory Cytokine Formation in Macrophages by Inducing TGF-β: Therapeutic Implications.

Journal of immunology (Baltimore, Md. : 1950)

Pallai A,Kiss B,Vereb G,Armaka M,Kollias G,Szekanecz Z,Szondy Z

Mon Feb 01 00:00:00 EST 2016

The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion.

Journal of immunology (Baltimore, Md. : 1950)

Tosh KW,Mittereder L,Bonne-Annee S,Hieny S,Nutman TB,Singer SM,Sher A,Jankovic D

Fri Jan 01 00:00:00 EST 2016

Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor.

Journal of immunology (Baltimore, Md. : 1950)

Peyrassol X,Laeremans T,Gouwy M,Lahura V,Debulpaep M,Van Damme J,Steyaert J,Parmentier M,Langer I

Tue Mar 15 00:00:00 EDT 2016

Anti-myeloma effect of pharmacological inhibition of Notch/gamma-secretase with RO4929097 is mediated by modulation of tumor microenvironment.

Cancer biology & therapy

Pisklakova A,Grigson E,Ozerova M,Chen F,Sullivan DM,Nefedova Y

300-25 was used in Cell Culture to study how targeting the Notch pathway, suggested to be implicated in growth and chemoresistance, could be beneficial for the treatment of multiple myeloma (MM).

Tue May 03 00:00:00 EDT 2016

Differential regulation of aldose reductase expression during macrophage polarization depends on hyperglycemia.

Innate immunity

Erbel C,Rupp G,Domschke G,Linden F,Akhavanpoor M,Doesch AO,Katus HA,Gleissner CA

300-25 was used in Cell Culture to show that aldose reductase (AR) expression in macrophages is associated with atherosclerosis and diabetes, and that AR expression is increased under hyperglycaemic conditions.

Fri Apr 01 00:00:00 EDT 2016

Rabbit M1 and M2 macrophages can be induced by human recombinant GM-CSF and M-CSF.

FEBS open bio

Yamane K,Leung KP

Thu Sep 01 00:00:00 EDT 2016

MiR-142-3p is a RANKL-dependent inducer of cell death in osteoclasts.

Scientific reports

Fordham JB,Guilfoyle K,Naqvi AR,Nares S

Tue Apr 26 00:00:00 EDT 2016

Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis.

Oncotarget

Fernández-Rodríguez R,Rodríguez-Baena FJ,Martino-Echarri E,Peris-Torres C,Del Carmen Plaza-Calonge M,Rodríguez-Manzaneque JC

300-25 was used in In vitro experiments to provide the first genetic evidence that supports the pro-tumorigenic role of stromal ADAMTS1.

Tue Jun 07 00:00:00 EDT 2016

IFN-γ Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages.

Cell reports

Qiao Y,Kang K,Giannopoulou E,Fang C,Ivashkiv LB

300-25 was used in Cell Culture to investigate signalling activation of immune response.

Tue Sep 20 00:00:00 EDT 2016

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

Scientific reports

Seow V,Lim J,Cotterell AJ,Yau MK,Xu W,Lohman RJ,Kok WM,Stoermer MJ,Sweet MJ,Reid RC,Suen JY,Fairlie DP

Wed Apr 20 00:00:00 EDT 2016

Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages.

Scientific reports

Huynh L,Kusnadi A,Park SH,Murata K,Park-Min KH,Ivashkiv LB

Thu Aug 25 00:00:00 EDT 2016

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation.

Nature communications

Li D,Liu J,Guo B,Liang C,Dang L,Lu C,He X,Cheung HY,Xu L,Lu C,He B,Liu B,Shaikh AB,Li F,Wang L,Yang Z,Au DW,Peng S,Zhang Z,Zhang BT,Pan X,Qian A,Shang P,Xiao L,Jiang B,Wong CK,Xu J,Bian Z,Liang Z,Guo DA,Zhu H,Tan W,Lu A,Zhang G

Mon Mar 07 00:00:00 EST 2016

Sorting nexin 10 acting as a novel regulator of macrophage polarization mediates inflammatory response in experimental mouse colitis.

Scientific reports

You Y,Zhou C,Li D,Cao ZL,Shen W,Li WZ,Zhang S,Hu B,Shen X

Tue Feb 09 00:00:00 EST 2016

Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.

The Journal of biological chemistry

Mei ZZ,Chen XY,Hu SW,Wang N,Ou XL,Wang J,Luo HH,Liu J,Jiang Y

Fri Aug 26 00:00:00 EDT 2016

miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer.

Scientific reports

Wang Z,Xu L,Hu Y,Huang Y,Zhang Y,Zheng X,Wang S,Wang Y,Yu Y,Zhang M,Yuan K,Min W

Mon May 09 00:00:00 EDT 2016

Cancer Cell-derived Exosomes Induce Mitogen-activated Protein Kinase-dependent Monocyte Survival by Transport of Functional Receptor Tyrosine Kinases.

The Journal of biological chemistry

Song X,Ding Y,Liu G,Yang X,Zhao R,Zhang Y,Zhao X,Anderson GJ,Nie G

Fri Apr 15 00:00:00 EDT 2016

Monocyte-derived macrophages exhibit distinct and more restricted HIV-1 integration site repertoire than CD4(+) T cells.

Scientific reports

Kok YL,Vongrad V,Shilaih M,Di Giallonardo F,Kuster H,Kouyos R,Günthard HF,Metzner KJ

Tue Apr 12 00:00:00 EDT 2016

Expression of the innate immune receptor LILRB5 on monocytes is associated with mycobacteria exposure.

Scientific reports

Hogan LE,Jones DC,Allen RL

Wed Feb 24 00:00:00 EST 2016

Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis.

Scientific reports

Chung IC,OuYang CN,Yuan SN,Li HP,Chen JT,Shieh HR,Chen YJ,Ojcius DM,Chu CL,Yu JS,Chang YS,Chen LC

Mon Oct 31 00:00:00 EDT 2016

miR-24, miR-30b and miR-142-3p interfere with antigen processing and presentation by primary macrophages and dendritic cells.

Scientific reports

Naqvi AR,Fordham JB,Ganesh B,Nares S

Fri Sep 09 00:00:00 EDT 2016

Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype.

Scientific reports

Harfuddin Z,Dharmadhikari B,Wong SC,Duan K,Poidinger M,Kwajah S,Schwarz H

Tue Jul 19 00:00:00 EDT 2016

Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration.

Cell death & disease

Szatmári-Tóth M,Kristóf E,Veréb Z,Akhtar S,Facskó A,Fésüs L,Kauppinen A,Kaarniranta K,Petrovski G

Thu Sep 08 00:00:00 EDT 2016

Secreted Thrombospondin-1 Regulates Macrophage Interleukin-1β Production and Activation through CD47.

Scientific reports

Stein EV,Miller TW,Ivins-O'Keefe K,Kaur S,Roberts DD

Wed Jan 27 00:00:00 EST 2016

Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages.

Nature communications

Canton J,Schlam D,Breuer C,Gütschow M,Glogauer M,Grinstein S

Wed Apr 06 00:00:00 EDT 2016

Human iPSC-derived osteoblasts and osteoclasts together promote bone regeneration in 3D biomaterials.

Scientific reports

Jeon OH,Panicker LM,Lu Q,Chae JJ,Feldman RA,Elisseeff JH

Thu May 26 00:00:00 EDT 2016

Structural simulation of adenosine phosphate via plumbagin and zoledronic acid competitively targets JNK/Erk to synergistically attenuate osteoclastogenesis in a breast cancer model.

Cell death & disease

Qiao H,Wang TY,Yu ZF,Han XG,Liu XQ,Wang YG,Fan QM,Qin A,Tang TT

Thu Feb 11 00:00:00 EST 2016

Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16(+) monocyte population via the IL-10/STAT3 axis.

Cell research

Lastrucci C,Bénard A,Balboa L,Pingris K,Souriant S,Poincloux R,Al Saati T,Rasolofo V,González-Montaner P,Inwentarz S,Moraña EJ,Kondova I,Verreck FA,Sasiain Mdel C,Neyrolles O,Maridonneau-Parini I,Lugo-Villarino G,Cougoule C

Tue Dec 01 00:00:00 EST 2015

IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.

Blood

Yáñez A,Ng MY,Hassanzadeh-Kiabi N,Goodridge HS

Thu Feb 26 00:00:00 EST 2015

Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.

The Journal of clinical investigation

Walter JE,Rosen LB,Csomos K,Rosenberg JM,Mathew D,Keszei M,Ujhazi B,Chen K,Lee YN,Tirosh I,Dobbs K,Al-Herz W,Cowan MJ,Puck J,Bleesing JJ,Grimley MS,Malech H,De Ravin SS,Gennery AR,Abraham RS,Joshi AY,Boyce TG,Butte MJ,Nadeau KC,Balboni I,Sullivan KE,Akhter J,Adeli M,El-Feky RA,El-Ghoneimy DH,Dbaibo G,Wakim R,Azzari C,Palma P,Cancrini C,Capuder K,Condino-Neto A,Costa-Carvalho BT,Oliveira JB,Roifman C,Buchbinder D,Kumanovics A,Franco JL,Niehues T,Schuetz C,Kuijpers T,Yee C,Chou J,Masaad MJ,Geha R,Uzel G,Gelman R,Holland SM,Recher M,Utz PJ,Browne SK,Notarangelo LD

Mon Nov 02 00:00:00 EST 2015

Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Lewis DR,Petersen LK,York AW,Zablocki KR,Joseph LB,Kholodovych V,Prud'homme RK,Uhrich KE,Moghe PV

Tue Mar 03 00:00:00 EST 2015

Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages.

Proceedings of the National Academy of Sciences of the United States of America

McClellan JS,Dove C,Gentles AJ,Ryan CE,Majeti R

Tue Mar 31 00:00:00 EDT 2015

Ionic imbalance, in addition to molecular crowding, abates cytoskeletal dynamics and vesicle motility during hypertonic stress.

Proceedings of the National Academy of Sciences of the United States of America

Nunes P,Roth I,Meda P,Féraille E,Brown D,Hasler U

Tue Jun 16 00:00:00 EDT 2015

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity.

Proceedings of the National Academy of Sciences of the United States of America

Schwartz MP,Hou Z,Propson NE,Zhang J,Engstrom CJ,Santos Costa V,Jiang P,Nguyen BK,Bolin JM,Daly W,Wang Y,Stewart R,Page CD,Murphy WL,Thomson JA

Tue Oct 06 00:00:00 EDT 2015

Serum amyloid A inhibits RANKL-induced osteoclast formation.

Experimental & molecular medicine

Oh E,Lee HY,Kim HJ,Park YJ,Seo JK,Park JS,Bae YS

Fri Nov 13 00:00:00 EST 2015

Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1.

Experimental & molecular medicine

Song MK,Lee ZH,Kim HH

Fri Dec 18 00:00:00 EST 2015

Effective Small Interfering RNA Therapy to Treat CLCN7-dependent Autosomal Dominant Osteopetrosis Type 2.

Molecular therapy. Nucleic acids

Capulli M,Maurizi A,Ventura L,Rucci N,Teti A

300-25 was used in Cell Culture to investigate miRNA effects on autosomal dominant osteopetrosis type 2.

Tue Sep 01 00:00:00 EDT 2015

Effective Small Interfering RNA Therapy to Treat CLCN7-dependent Autosomal Dominant Osteopetrosis Type 2.

Molecular therapy. Nucleic acids

Capulli M,Maurizi A,Ventura L,Rucci N,Teti A

300-25 was used in Cell Culture to investigate miRNA effects on autosomal dominant osteopetrosis type 2.

Tue Sep 01 00:00:00 EDT 2015

The implication of cigarette smoking and cessation on macrophage cholesterol efflux in coronary artery disease patients.

Journal of lipid research

Song W,Wang W,Dou LY,Wang Y,Xu Y,Chen LF,Yan XW

Sun Mar 01 00:00:00 EST 2015

Lipocalin 2: a new mechanoresponding gene regulating bone homeostasis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Rucci N,Capulli M,Piperni SG,Cappariello A,Lau P,Frings-Meuthen P,Heer M,Teti A

300-25 was used in Cell Culture to investigate mechanoresponding properties of LCN2 in mouse osteoblasts.

Sun Feb 01 00:00:00 EST 2015

Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis.

Journal of immunology (Baltimore, Md. : 1950)

Andrade BB,Pavan Kumar N,Amaral EP,Riteau N,Mayer-Barber KD,Tosh KW,Maier N,Conceição EL,Kubler A,Sridhar R,Banurekha VV,Jawahar MS,Barbosa T,Manganiello VC,Moss J,Fontana JR,Marciano BE,Sampaio EP,Olivier KN,Holland SM,Jackson SH,Moayeri M,Leppla S,Sereti I,Barber DL,Nutman TB,Babu S,Sher A

Tue Sep 15 00:00:00 EDT 2015

The human fetal placenta promotes tolerance against the semiallogeneic fetus by inducing regulatory T cells and homeostatic M2 macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Svensson-Arvelund J,Mehta RB,Lindau R,Mirrasekhian E,Rodriguez-Martinez H,Berg G,Lash GE,Jenmalm MC,Ernerudh J

Sun Feb 15 00:00:00 EST 2015

Macrophage epoxygenase determines a profibrotic transcriptome signature.

Journal of immunology (Baltimore, Md. : 1950)

Behmoaras J,Diaz AG,Venda L,Ko JH,Srivastava P,Montoya A,Faull P,Webster Z,Moyon B,Pusey CD,Abraham DJ,Petretto E,Cook TH,Aitman TJ

Fri May 15 00:00:00 EDT 2015

Sos1 Regulates Macrophage Podosome Assembly and Macrophage Invasive Capacity.

Journal of immunology (Baltimore, Md. : 1950)

Baruzzi A,Remelli S,Lorenzetto E,Sega M,Chignola R,Berton G

Sun Nov 15 00:00:00 EST 2015

miR-24, miR-30b, and miR-142-3p regulate phagocytosis in myeloid inflammatory cells.

Journal of immunology (Baltimore, Md. : 1950)

Naqvi AR,Fordham JB,Nares S

Sun Feb 15 00:00:00 EST 2015

Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB.

Journal of immunology (Baltimore, Md. : 1950)

Ostrop J,Jozefowski K,Zimmermann S,Hofmann K,Strasser E,Lepenies B,Lang R

Tue Sep 01 00:00:00 EDT 2015

Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury.

Scientific reports

Scheiermann P,Bachmann M,Härdle L,Pleli T,Piiper A,Zwissler B,Pfeilschifter J,Mühl H

Tue Feb 17 00:00:00 EST 2015

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss.

Nature communications

Harre U,Lang SC,Pfeifle R,Rombouts Y,Frühbeißer S,Amara K,Bang H,Lux A,Koeleman CA,Baum W,Dietel K,Gröhn F,Malmström V,Klareskog L,Krönke G,Kocijan R,Nimmerjahn F,Toes RE,Herrmann M,Scherer HU,Schett G

Tue Mar 31 00:00:00 EDT 2015

Osteoblast menin regulates bone mass in vivo.

The Journal of biological chemistry

Kanazawa I,Canaff L,Abi Rafeh J,Angrula A,Li J,Riddle RC,Boraschi-Diaz I,Komarova SV,Clemens TL,Murshed M,Hendy GN

300-25 was used in Cell Culture to conclude that osteoblast menin plays a key role in bone development, remodeling, and maintenance.

Fri Feb 13 00:00:00 EST 2015

IL-10 induces the development of immunosuppressive CD14(+)HLA-DR(low/-) monocytes in B-cell non-Hodgkin lymphoma.

Blood cancer journal

Xiu B,Lin Y,Grote DM,Ziesmer SC,Gustafson MP,Maas ML,Zhang Z,Dietz AB,Porrata LF,Novak AJ,Liang AB,Yang ZZ,Ansell SM

Fri Jul 31 00:00:00 EDT 2015

Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor κB (RANK)-dependent formation of multinucleated osteoclasts.

The Journal of biological chemistry

Oh J,Kim JY,Kim HS,Oh JC,Cheon YH,Park J,Yoon KH,Lee MS,Youn BS

Fri Jan 23 00:00:00 EST 2015

Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor κB (RANK)-dependent formation of multinucleated osteoclasts.

The Journal of biological chemistry

Oh J,Kim JY,Kim HS,Oh JC,Cheon YH,Park J,Yoon KH,Lee MS,Youn BS

Fri Jan 23 00:00:00 EST 2015

Integrated Transcriptomics Establish Macrophage Polarization Signatures and have Potential Applications for Clinical Health and Disease.

Scientific reports

Becker M,De Bastiani MA,Parisi MM,Guma FT,Markoski MM,Castro MA,Kaplan MH,Barbé-Tuana FM,Klamt F

Tue Aug 25 00:00:00 EDT 2015

Caveolin-1 regulates osteoclastogenesis and bone metabolism in a sex-dependent manner.

The Journal of biological chemistry

Lee YD,Yoon SH,Park CK,Lee J,Lee ZH,Kim HH

Fri Mar 06 00:00:00 EST 2015

Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss.

Scientific reports

Zhang Y,Guan H,Li J,Fang Z,Chen W,Li F

Fri Sep 04 00:00:00 EDT 2015

Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss.

Scientific reports

Zhang Y,Guan H,Li J,Fang Z,Chen W,Li F

Fri Sep 04 00:00:00 EDT 2015

The role of H4 flagella in Escherichia coli ST131 virulence.

Scientific reports

Kakkanat A,Totsika M,Schaale K,Duell BL,Lo AW,Phan MD,Moriel DG,Beatson SA,Sweet MJ,Ulett GC,Schembri MA

Mon Nov 09 00:00:00 EST 2015

AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages.

Cell death & disease

Six E,Lagresle-Peyrou C,Susini S,De Chappedelaine C,Sigrist N,Sadek H,Chouteau M,Cagnard N,Fontenay M,Hermine O,Chomienne C,Reynier P,Fischer A,André-Schmutz I,Gueguen N,Cavazzana M

Thu Aug 13 00:00:00 EDT 2015

Monocyte-derived macrophage assisted breast cancer cell invasion as a personalized, predictive metric to score metastatic risk.

Scientific reports

Park KY,Li G,Platt MO

Wed Sep 09 00:00:00 EDT 2015

A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.

Nature

Murthy A,Li Y,Peng I,Reichelt M,Katakam AK,Noubade R,Roose-Girma M,DeVoss J,Diehl L,Graham RR,van Lookeren Campagne M

Thu Feb 27 00:00:00 EST 2014

Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD.

Blood

Awojoodu AO,Keegan PM,Lane AR,Zhang Y,Lynch KR,Platt MO,Botchwey EA

Thu Sep 18 00:00:00 EDT 2014

Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy.

Blood

Heczey A,Liu D,Tian G,Courtney AN,Wei J,Marinova E,Gao X,Guo L,Yvon E,Hicks J,Liu H,Dotti G,Metelitsa LS

Thu Oct 30 00:00:00 EDT 2014

Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry.

The Journal of experimental medicine

Williams GR,Fierens K,Preston SG,Lunn D,Rysnik O,De Prijck S,Kool M,Buckley HC,Lambrecht BN,O'Hare D,Austyn JM

Mon Jun 02 00:00:00 EDT 2014

The phosphoinositide 3-kinase isoform PI3Kβ regulates osteoclast-mediated bone resorption in humans and mice.

Arthritis & rheumatology (Hoboken, N.J.)

Győri D,Csete D,Benkő S,Kulkarni S,Mandl P,Dobó-Nagy C,Vanhaesebroeck B,Stephens L,Hawkins PT,Mócsai A

Fri Aug 01 00:00:00 EDT 2014

The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia.

Cell death and differentiation

Gong JN,Yu J,Lin HS,Zhang XH,Yin XL,Xiao Z,Wang F,Wang XS,Su R,Shen C,Zhao HL,Ma YN,Zhang JW

Wed Jan 01 00:00:00 EST 2014

ABCG1-mediated generation of extracellular cholesterol microdomains.

Journal of lipid research

Freeman SR,Jin X,Anzinger JJ,Xu Q,Purushothaman S,Fessler MB,Addadi L,Kruth HS

Wed Jan 01 00:00:00 EST 2014

Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells.

Journal of immunology (Baltimore, Md. : 1950)

Pauls E,Ruiz A,Badia R,Permanyer M,Gubern A,Riveira-Muñoz E,Torres-Torronteras J,Alvarez M,Mothe B,Brander C,Crespo M,Menéndez-Arias L,Clotet B,Keppler OT,Martí R,Posas F,Ballana E,Esté JA

Fri Aug 15 00:00:00 EDT 2014

Glycoengineering of therapeutic antibodies enhances monocyte/macrophage-mediated phagocytosis and cytotoxicity.

Journal of immunology (Baltimore, Md. : 1950)

Herter S,Birk MC,Klein C,Gerdes C,Umana P,Bacac M

Sat Mar 01 00:00:00 EST 2014

Cell death triggered by Yersinia enterocolitica identifies processing of the proinflammatory signal adapter MyD88 as a general event in the execution of apoptosis.

Journal of immunology (Baltimore, Md. : 1950)

Novikova L,Czymmeck N,Deuretzbacher A,Buck F,Richter K,Weber AN,Aepfelbacher M,Ruckdeschel K

Sat Feb 01 00:00:00 EST 2014

Human IgA Fc receptor FcαRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment.

Journal of immunology (Baltimore, Md. : 1950)

Wehrli M,Cortinas-Elizondo F,Hlushchuk R,Daudel F,Villiger PM,Miescher S,Zuercher AW,Djonov V,Simon HU,von Gunten S

Mon Dec 01 00:00:00 EST 2014

Modulation of TNF-induced macrophage polarization by synovial fibroblasts.

Journal of immunology (Baltimore, Md. : 1950)

Donlin LT,Jayatilleke A,Giannopoulou EG,Kalliolias GD,Ivashkiv LB

Mon Sep 01 00:00:00 EDT 2014

Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge.

Cell death & disease

Través PG,Pardo V,Pimentel-Santillana M,González-Rodríguez Á,Mojena M,Rico D,Montenegro Y,Calés C,Martín-Sanz P,Valverde AM,Boscá L

Thu Mar 13 00:00:00 EDT 2014

RelB-induced expression of Cot, an MAP3K family member, rescues RANKL-induced osteoclastogenesis in alymphoplasia mice by promoting NF-κB2 processing by IKKα.

The Journal of biological chemistry

Taniguchi R,Fukushima H,Osawa K,Maruyama T,Yasuda H,Weih F,Doi T,Maki K,Jimi E

Fri Mar 14 00:00:00 EDT 2014

Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization.

The Journal of biological chemistry

He L,Marneros AG

Fri Mar 21 00:00:00 EDT 2014

HIV-1 infection induces interleukin-1β production via TLR8 protein-dependent and NLRP3 inflammasome mechanisms in human monocytes.

The Journal of biological chemistry

Guo H,Gao J,Taxman DJ,Ting JP,Su L

Fri Aug 01 00:00:00 EDT 2014

Characterization of the influence of mediator complex in HIV-1 transcription.

The Journal of biological chemistry

Ruiz A,Pauls E,Badia R,Riveira-Muñoz E,Clotet B,Ballana E,Esté JA

Fri Oct 03 00:00:00 EDT 2014

Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate.

Scientific reports

Purdue PE,Crotti TN,Shen Z,Swantek J,Li J,Hill J,Hanidu A,Dimock J,Nabozny G,Goldring SR,McHugh KP

Tue Dec 23 00:00:00 EST 2014

Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.

The Journal of biological chemistry

Levy-Apter E,Finkelshtein E,Vemulapalli V,Li SS,Bedford MT,Elson A

Fri Dec 26 00:00:00 EST 2014

Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.

The Journal of biological chemistry

Levy-Apter E,Finkelshtein E,Vemulapalli V,Li SS,Bedford MT,Elson A

Fri Dec 26 00:00:00 EST 2014

Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling.

Immunity

Qiao Y,Giannopoulou EG,Chan CH,Park SH,Gong S,Chen J,Hu X,Elemento O,Ivashkiv LB

Thu Sep 19 00:00:00 EDT 2013

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.

Blood

Martinez FO,Helming L,Milde R,Varin A,Melgert BN,Draijer C,Thomas B,Fabbri M,Crawshaw A,Ho LP,Ten Hacken NH,Cobos Jiménez V,Kootstra NA,Hamann J,Greaves DR,Locati M,Mantovani A,Gordon S

Thu Feb 28 00:00:00 EST 2013

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.

The Journal of clinical investigation

Issuree PD,Maretzky T,McIlwain DR,Monette S,Qing X,Lang PA,Swendeman SL,Park-Min KH,Binder N,Kalliolias GD,Yarilina A,Horiuchi K,Ivashkiv LB,Mak TW,Salmon JE,Blobel CP

Fri Feb 01 00:00:00 EST 2013

Identification of human CCR8 as a CCL18 receptor.

The Journal of experimental medicine

Islam SA,Ling MF,Leung J,Shreffler WG,Luster AD

Mon Sep 23 00:00:00 EDT 2013

Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models.

Molecular cancer therapeutics

Herter S,Herting F,Mundigl O,Waldhauer I,Weinzierl T,Fauti T,Muth G,Ziegler-Landesberger D,Van Puijenbroek E,Lang S,Duong MN,Reslan L,Gerdes CA,Friess T,Baer U,Burtscher H,Weidner M,Dumontet C,Umana P,Niederfellner G,Bacac M,Klein C

300-25 was used in Sample Preparation (FC/FACS) to show that the glyoengineered type II CD20 antibody GA101 is differentiated from the two approved type I CD20 antibodies rituximab and ofatumumab by its overall preclinical activity, further supporting its clinical investigation.

Tue Oct 01 00:00:00 EDT 2013

Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses.

Journal of immunology (Baltimore, Md. : 1950)

Través PG,Pimentel-Santillana M,Carrasquero LM,Pérez-Sen R,Delicado EG,Luque A,Izquierdo M,Martín-Sanz P,Miras-Portugal MT,Boscá L

Mon Apr 15 00:00:00 EDT 2013

Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.

Journal of immunology (Baltimore, Md. : 1950)

Seow V,Lim J,Iyer A,Suen JY,Ariffin JK,Hohenhaus DM,Sweet MJ,Fairlie DP

Tue Oct 15 00:00:00 EDT 2013

Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques.

Journal of immunology (Baltimore, Md. : 1950)

Kotani M,Kikuta J,Klauschen F,Chino T,Kobayashi Y,Yasuda H,Tamai K,Miyawaki A,Kanagawa O,Tomura M,Ishii M

Tue Jan 15 00:00:00 EST 2013

Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1.

Journal of immunology (Baltimore, Md. : 1950)

Pauls E,Jimenez E,Ruiz A,Permanyer M,Ballana E,Costa H,Nascimiento R,Parkhouse RM,Peña R,Riveiro-Muñoz E,Martinez MA,Clotet B,Esté JA,Bofill M

Wed May 01 00:00:00 EDT 2013

IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids.

Journal of immunology (Baltimore, Md. : 1950)

Zizzo G,Cohen PL

Wed May 15 00:00:00 EDT 2013

An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R

Tue Jan 01 00:00:00 EST 2013

Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism.

Journal of cell science

Tiedemann K,Boraschi-Diaz I,Rajakumar I,Kaur J,Roughley P,Reinhardt DP,Komarova SV

300-25 was used in Cell Culture to highlight a direct dual inhibitory role of N-terminal fibrillin-1 fragments in osteoclastogenesis, the sequestration of RANKL and the inhibition of NFATc1 signaling.

Sun Sep 15 00:00:00 EDT 2013

Moderate excess of pyruvate augments osteoclastogenesis.

Biology open

Fong JE,Le Nihouannen D,Tiedemann K,Sadvakassova G,Barralet JE,Komarova SV

300-25 was used in Cell Culture to study how the differentiation of bone-resorbing osteoclasts, large polykaryons formed through fusion and growth of cells of monocytic origin, is affected by excess of energy substrate pyruvate and how energy metabolism changes during osteoclast differentiation.

Mon Apr 15 00:00:00 EDT 2013

A recombinant fusion toxin based on enzymatic inactive C3bot1 selectively targets macrophages.

PloS one

Dmochewitz L,Förtsch C,Zwerger C,Vaeth M,Felder E,Huber-Lang M,Barth H

Fri Jul 19 00:00:00 EDT 2013

Molecular signaling pathways mediating osteoclastogenesis induced by prostate cancer cells.

BMC cancer

Rafiei S,Komarova SV

300-25 was used in Cell Culture to study the molecular mechanism of prostate cancer-induced osteoclastogenesis following metastasis.

Thu Dec 26 00:00:00 EST 2013

The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.

The Journal of biological chemistry

Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL

Fri Jul 19 00:00:00 EDT 2013

Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.

PloS one

Fossati-Jimack L,Ling GS,Cortini A,Szajna M,Malik TH,McDonald JU,Pickering MC,Cook HT,Taylor PR,Botto M

Fri Sep 27 00:00:00 EDT 2013

Purification of Human Monocytes and Lymphocyte Populations by Counter Current Elutriation- A Short Protocol.

Bio-protocol

Clarke EV,Benoit ME,Tenner AJ

300-25 was used in Cell Culture to outline human blood monocyte isolation with counterflow elutriation.

Thu Dec 05 00:00:00 EST 2013

Vav1 fine tunes p53 control of apoptosis versus proliferation in breast cancer.

PloS one

Sebban S,Farago M,Gashai D,Ilan L,Pikarsky E,Ben-Porath I,Katzav S

Fri Aug 02 00:00:00 EDT 2013

A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses.

Nature

Litvak V,Ratushny AV,Lampano AE,Schmitz F,Huang AC,Raman A,Rust AG,Bergthaler A,Aitchison JD,Aderem A

Thu Oct 18 00:00:00 EDT 2012

The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes.

Annals of the rheumatic diseases

Rhodes B,Fürnrohr BG,Roberts AL,Tzircotis G,Schett G,Spector TD,Vyse TJ

Sat Dec 01 00:00:00 EST 2012

Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice.

Blood

Wroblewska A,van Haren SD,Herczenik E,Kaijen P,Ruminska A,Jin SY,Zheng XL,van den Biggelaar M,ten Brinke A,Meijer AB,Voorberg J

Thu May 31 00:00:00 EDT 2012

Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology.

Blood

Pello OM,De Pizzol M,Mirolo M,Soucek L,Zammataro L,Amabile A,Doni A,Nebuloni M,Swigart LB,Evan GI,Mantovani A,Locati M

Thu Jan 12 00:00:00 EST 2012

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.

Blood

Tai YT,Chang BY,Kong SY,Fulciniti M,Yang G,Calle Y,Hu Y,Lin J,Zhao JJ,Cagnetta A,Cea M,Sellitto MA,Zhong MY,Wang Q,Acharya C,Carrasco DR,Buggy JJ,Elias L,Treon SP,Matsui W,Richardson P,Munshi NC,Anderson KC

Thu Aug 30 00:00:00 EDT 2012

Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma.

Blood

Koduru S,Wong E,Strowig T,Sundaram R,Zhang L,Strout MP,Flavell RA,Schatz DG,Dhodapkar KM,Dhodapkar MV

Thu Mar 08 00:00:00 EST 2012

ARHGAP25, a novel Rac GTPase-activating protein, regulates phagocytosis in human neutrophilic granulocytes.

Blood

Csépányi-Kömi R,Sirokmány G,Geiszt M,Ligeti E

Thu Jan 12 00:00:00 EST 2012

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin.

The Journal of clinical investigation

Harre U,Georgess D,Bang H,Bozec A,Axmann R,Ossipova E,Jakobsson PJ,Baum W,Nimmerjahn F,Szarka E,Sarmay G,Krumbholz G,Neumann E,Toes R,Scherer HU,Catrina AI,Klareskog L,Jurdic P,Schett G

Tue May 01 00:00:00 EDT 2012

C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice.

The Journal of clinical investigation

Kyme P,Thoennissen NH,Tseng CW,Thoennissen GB,Wolf AJ,Shimada K,Krug UO,Lee K,Müller-Tidow C,Berdel WE,Hardy WD,Gombart AF,Koeffler HP,Liu GY

Sat Sep 01 00:00:00 EDT 2012

Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes.

Nucleic acids research

Rodríguez-Ubreva J,Ciudad L,Gómez-Cabrero D,Parra M,Bussmann LH,di Tullio A,Kallin EM,Tegnér J,Graf T,Ballestar E

Thu Mar 01 00:00:00 EST 2012

Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.

The Journal of experimental medicine

Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H

Mon Oct 22 00:00:00 EDT 2012

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.

The Journal of experimental medicine

Zhao B,Grimes SN,Li S,Hu X,Ivashkiv LB

Mon Feb 13 00:00:00 EST 2012

A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells.

Autophagy

Phadwal K,Alegre-Abarrategui J,Watson AS,Pike L,Anbalagan S,Hammond EM,Wade-Martins R,McMichael A,Klenerman P,Simon AK

Sun Apr 01 00:00:00 EDT 2012

Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway.

Autophagy

Chong A,Wehrly TD,Child R,Hansen B,Hwang S,Virgin HW,Celli J

300-25 was used in Cell Culture to demonstrate that replication-impaired strains of Francisella are cleared by autophagy, while replication-competent bacteria seem to interfere with autophagic recognition.

Sat Sep 01 00:00:00 EDT 2012

IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes.

Proceedings of the National Academy of Sciences of the United States of America

Rossato M,Curtale G,Tamassia N,Castellucci M,Mori L,Gasperini S,Mariotti B,De Luca M,Mirolo M,Cassatella MA,Locati M,Bazzoni F

Tue Nov 06 00:00:00 EST 2012

Direct and immune mediated antibody targeting of ERBB receptors in a colorectal cancer cell-line panel.

Proceedings of the National Academy of Sciences of the United States of America

Ashraf SQ,Nicholls AM,Wilding JL,Ntouroupi TG,Mortensen NJ,Bodmer WF

Tue Dec 18 00:00:00 EST 2012

Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice.

Proceedings of the National Academy of Sciences of the United States of America

Nakamichi Y,Mizoguchi T,Arai A,Kobayashi Y,Sato M,Penninger JM,Yasuda H,Kato S,DeLuca HF,Suda T,Udagawa N,Takahashi N

Tue Jun 19 00:00:00 EDT 2012

Paracrine interactions between primary human macrophages and human fibroblasts enhance murine mammary gland humanization in vivo.

Breast cancer research : BCR

Fleming JM,Miller TC,Kidacki M,Ginsburg E,Stuelten CH,Stewart DA,Troester MA,Vonderhaar BK

Mon Jun 25 00:00:00 EDT 2012

ABCC5 supports osteoclast formation and promotes breast cancer metastasis to bone.

Breast cancer research : BCR

Mourskaia AA,Amir E,Dong Z,Tiedemann K,Cory S,Omeroglu A,Bertos N,Ouellet V,Clemons M,Scheffer GL,Park M,Hallett M,Komarova SV,Siegel PM

300-25 was used in Cell Culture to investigate molecular mechanisms of bone metastasis.

Thu Nov 22 00:00:00 EST 2012

Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis.

Arthritis research & therapy

Hwang SJ,Choi B,Kang SS,Chang JH,Kim YG,Chung YH,Sohn DH,So MW,Lee CK,Robinson WH,Chang EJ

Fri Jan 20 00:00:00 EST 2012

Purinergic receptors are required for HIV-1 infection of primary human macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Hazleton JE,Berman JW,Eugenin EA

Tue May 01 00:00:00 EDT 2012

Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial growth factor-A expression in macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Meda C,Molla F,De Pizzol M,Regano D,Maione F,Capano S,Locati M,Mantovani A,Latini R,Bussolino F,Giraudo E

Sun Apr 15 00:00:00 EDT 2012

ITAM-coupled receptors inhibit IFNAR signaling and alter macrophage responses to TLR4 and Listeria monocytogenes.

Journal of immunology (Baltimore, Md. : 1950)

Huynh L,Wang L,Shi C,Park-Min KH,Ivashkiv LB

Sun Apr 01 00:00:00 EDT 2012

HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule.

Journal of immunology (Baltimore, Md. : 1950)

Lenormand C,Bausinger H,Gross F,Signorino-Gelo F,Koch S,Peressin M,Fricker D,Cazenave JP,Bieber T,Hanau D,de la Salle H,Tourne S

Sun Apr 15 00:00:00 EDT 2012

NLRC4 inflammasome-mediated production of IL-1β modulates mucosal immunity in the lung against gram-negative bacterial infection.

Journal of immunology (Baltimore, Md. : 1950)

Cai S,Batra S,Wakamatsu N,Pacher P,Jeyaseelan S

Fri Jun 01 00:00:00 EDT 2012

Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism.

Journal of immunology (Baltimore, Md. : 1950)

Agbanoma G,Li C,Ennis D,Palfreeman AC,Williams LM,Brennan FM

Wed Feb 01 00:00:00 EST 2012

Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells.

Journal of immunology (Baltimore, Md. : 1950)

Benoit ME,Clarke EV,Morgado P,Fraser DA,Tenner AJ

Fri Jun 01 00:00:00 EDT 2012

Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.

Journal of immunology (Baltimore, Md. : 1950)

Zizzo G,Hilliard BA,Monestier M,Cohen PL

Mon Oct 01 00:00:00 EDT 2012

Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.

PloS one

Chaudhuri N,Jary H,Lea S,Khan N,Piddock KC,Dockrell DH,Donaldson K,Duffin R,Singh D,Parker LC,Sabroe I

Fri May 24 00:00:00 EDT 2013

TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis.

The Journal of biological chemistry

Yoon SH,Lee YD,Ha J,Lee Y,Kim HH

Fri Aug 24 00:00:00 EDT 2012

Adipokines in psoriatic arthritis patients: the correlations with osteoclast precursors and bone erosions.

PloS one

Xue Y,Jiang L,Cheng Q,Chen H,Yu Y,Lin Y,Yang X,Kong N,Zhu X,Xu X,Wan W,Zou H

Tue Aug 26 00:00:00 EDT 2014

Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors.

PloS one

Kawamura K,Chen Y,Shu Y,Cheng Y,Qiao J,Behr B,Pera RA,Hsueh AJ

Tue May 07 00:00:00 EDT 2013

Prevention of bone growth defects, increased bone resorption and marrow adiposity with folinic acid in rats receiving long-term methotrexate.

PloS one

Fan CM,Foster BK,Hui SK,Xian CJ

Thu Apr 11 00:00:00 EDT 2013

Tailored enrichment strategy detects low abundant small noncoding RNAs in HIV-1 infected cells.

Retrovirology

Althaus CF,Vongrad V,Niederöst B,Joos B,Di Giallonardo F,Rieder P,Pavlovic J,Trkola A,Günthard HF,Metzner KJ,Fischer M

Thu Mar 29 00:00:00 EDT 2012

Characterization and function of the human macrophage dopaminergic system: implications for CNS disease and drug abuse.

Journal of neuroinflammation

Gaskill PJ,Carvallo L,Eugenin EA,Berman JW

Sat Aug 18 00:00:00 EDT 2012

Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

The Journal of biological chemistry

Lohse S,Brunke C,Derer S,Peipp M,Boross P,Kellner C,Beyer T,Dechant M,van der Winkel JG,Leusen JH,Valerius T

Fri Jul 20 00:00:00 EDT 2012

Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process.

PloS one

Ortiz-Masià D,Díez I,Calatayud S,Hernández C,Cosín-Roger J,Hinojosa J,Esplugues JV,Barrachina MD

Wed Apr 10 00:00:00 EDT 2013

Divergent resorbability and effects on osteoclast formation of commonly used bone substitutes in a human in vitro-assay.

PloS one

Keller J,Brink S,Busse B,Schilling AF,Schinke T,Amling M,Lange T

Tue Apr 02 00:00:00 EDT 2013

Macrophage mesenchymal migration requires podosome stabilization by filamin A.

The Journal of biological chemistry

Guiet R,Vérollet C,Lamsoul I,Cougoule C,Poincloux R,Labrousse A,Calderwood DA,Glogauer M,Lutz PG,Maridonneau-Parini I

Fri Apr 13 00:00:00 EDT 2012

MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency.

Retrovirology

Grupping K,Selhorst P,Michiels J,Vereecken K,Heyndrickx L,Kessler P,Vanham G,Martin L,Ariën KK

Wed May 02 00:00:00 EDT 2012

The chemerin/ChemR23 system does not affect the pro-inflammatory response of mouse and human macrophages ex vivo.

PloS one

Bondue B,De Henau O,Luangsay S,Devosse T,de Nadaï P,Springael JY,Parmentier M,Vosters O

Tue Nov 27 00:00:00 EST 2012

Rho GTPase expression in human myeloid cells.

PloS one

van Helden SF,Anthony EC,Dee R,Hordijk PL

Wed May 15 00:00:00 EDT 2013

Monocytes contribute to differential immune pressure on R5 versus X4 HIV through the adipocytokine visfatin/NAMPT.

PloS one

Van den Bergh R,Morin S,Sass HJ,Grzesiek S,Vekemans M,Florence E,Tran HT,Imiru RG,Heyndrickx L,Vanham G,De Baetselier P,Raes G

Tue Sep 04 00:00:00 EDT 2012

Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects.

PloS one

Garcia-Gomez A,Ocio EM,Crusoe E,Santamaria C,Hernández-Campo P,Blanco JF,Sanchez-Guijo FM,Hernández-Iglesias T,Briñón JG,Fisac-Herrero RM,Lee FY,Pandiella A,San Miguel JF,Garayoa M

Mon Sep 10 00:00:00 EDT 2012

Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.

Immunity

Mayer-Barber KD,Andrade BB,Barber DL,Hieny S,Feng CG,Caspar P,Oland S,Gordon S,Sher A

Fri Dec 23 00:00:00 EST 2011

TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes.

Blood

Fox JM,Letellier E,Oliphant CJ,Signoret N

Thu Feb 10 00:00:00 EST 2011

Osteoclast-gene expression profiling reveals osteoclast-derived CCR2 chemokines promoting myeloma cell migration.

Blood

Moreaux J,Hose D,Kassambara A,Reme T,Moine P,Requirand G,Goldschmidt H,Klein B

Thu Jan 27 00:00:00 EST 2011

Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy.

Blood

Lim SH,Vaughan AT,Ashton-Key M,Williams EL,Dixon SV,Chan HT,Beers SA,French RR,Cox KL,Davies AJ,Potter KN,Mockridge CI,Oscier DG,Johnson PW,Cragg MS,Glennie MJ

Thu Sep 01 00:00:00 EDT 2011

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions.

Blood

Klimchenko O,Di Stefano A,Geoerger B,Hamidi S,Opolon P,Robert T,Routhier M,El-Benna J,Delezoide AL,Boukour S,Lescure B,Solary E,Vainchenker W,Norol F

Thu Mar 17 00:00:00 EDT 2011

The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation.

The Journal of clinical investigation

Wu X,Gao H,Ke W,Giese RW,Zhu Z

Fri Jul 01 00:00:00 EDT 2011

Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis.

The Journal of clinical investigation

Song JJ,Hwang I,Cho KH,Garcia MA,Kim AJ,Wang TH,Lindstrom TM,Lee AT,Nishimura T,Zhao L,Morser J,Nesheim M,Goodman SB,Lee DM,Bridges SL,Gregersen PK,Leung LL,Robinson WH

Thu Sep 01 00:00:00 EDT 2011

Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection.

The Journal of experimental medicine

Séror C,Melki MT,Subra F,Raza SQ,Bras M,Saïdi H,Nardacci R,Voisin L,Paoletti A,Law F,Martins I,Amendola A,Abdul-Sater AA,Ciccosanti F,Delelis O,Niedergang F,Thierry S,Said-Sadier N,Lamaze C,Métivier D,Estaquier J,Fimia GM,Falasca L,Casetti R,Modjtahedi N,Kanellopoulos J,Mouscadet JF,Ojcius DM,Piacentini M,Gougeon ML,Kroemer G,Perfettini JL

Mon Aug 29 00:00:00 EDT 2011

Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.

Nature protocols

Choi KD,Vodyanik M,Slukvin II

Tue Mar 01 00:00:00 EST 2011

Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.

Nature protocols

Choi KD,Vodyanik M,Slukvin II

Tue Mar 01 00:00:00 EST 2011

Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.

Proceedings of the National Academy of Sciences of the United States of America

Beavis PA,Gregory B,Green P,Cribbs AP,Kennedy A,Amjadi P,Palfreeman AC,Feldmann M,Brennan FM

Tue Oct 04 00:00:00 EDT 2011

TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages.

Proceedings of the National Academy of Sciences of the United States of America

Yarilina A,Xu K,Chen J,Ivashkiv LB

Tue Jan 25 00:00:00 EST 2011

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.

Proceedings of the National Academy of Sciences of the United States of America

Zak DE,Schmitz F,Gold ES,Diercks AH,Peschon JJ,Valvo JS,Niemistö A,Podolsky I,Fallen SG,Suen R,Stolyar T,Johnson CD,Kennedy KA,Hamilton MK,Siggs OM,Beutler B,Aderem A

Tue Jul 12 00:00:00 EDT 2011

MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases.

Breast cancer research : BCR

Pivetta E,Scapolan M,Pecolo M,Wassermann B,Abu-Rumeileh I,Balestreri L,Borsatti E,Tripodo C,Colombatti A,Spessotto P

Thu Oct 27 00:00:00 EDT 2011

Human macrophage responses to clinical isolates from the Mycobacterium tuberculosis complex discriminate between ancient and modern lineages.

PLoS pathogens

Portevin D,Gagneux S,Comas I,Young D

Tue Mar 01 00:00:00 EST 2011

Macrophages at the fetal-maternal interface express markers of alternative activation and are induced by M-CSF and IL-10.

Journal of immunology (Baltimore, Md. : 1950)

Svensson J,Jenmalm MC,Matussek A,Geffers R,Berg G,Ernerudh J

Sat Oct 01 00:00:00 EDT 2011

β5 integrin is the major contributor to the αVintegrin-mediated blockade of HIV-1 replication.

Journal of immunology (Baltimore, Md. : 1950)

Ballana E,Pauls E,Clotet B,Perron-Sierra F,Tucker GC,Esté JA

Sat Jan 01 00:00:00 EST 2011

Transcriptional suppression of IL-27 production by Mycobacterium tuberculosis-activated p38 MAPK via inhibition of AP-1 binding.

Journal of immunology (Baltimore, Md. : 1950)

Zhang J,Qian X,Ning H,Eickhoff CS,Hoft DF,Liu J

Sun May 15 00:00:00 EDT 2011

Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1β production in human macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Novikov A,Cardone M,Thompson R,Shenderov K,Kirschman KD,Mayer-Barber KD,Myers TG,Rabin RL,Trinchieri G,Sher A,Feng CG

Thu Sep 01 00:00:00 EDT 2011

Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis.

Journal of immunology (Baltimore, Md. : 1950)

Bruscia EM,Zhang PX,Satoh A,Caputo C,Medzhitov R,Shenoy A,Egan ME,Krause DS

Wed Jun 15 00:00:00 EDT 2011

Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1.

Journal of immunology (Baltimore, Md. : 1950)

Smolinska MJ,Page TH,Urbaniak AM,Mutch BE,Horwood NJ

Thu Dec 01 00:00:00 EST 2011

IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis.

Journal of immunology (Baltimore, Md. : 1950)

Ansari NA,Kumar R,Gautam S,Nylén S,Singh OP,Sundar S,Sacks D

Fri Apr 01 00:00:00 EDT 2011

Degradation, bioactivity, and osteogenic potential of composites made of PLGA and two different sol-gel bioactive glasses.

Annals of biomedical engineering

Pamula E,Kokoszka J,Cholewa-Kowalska K,Laczka M,Kantor L,Niedzwiedzki L,Reilly GC,Filipowska J,Madej W,Kolodziejczyk M,Tylko G,Osyczka AM

Mon Aug 01 00:00:00 EDT 2011

Autologous serum improves yield and metabolic capacity of monocyte-derived hepatocyte-like cells: possible implication for cell transplantation.

Cell transplantation

Ehnert S,Seeliger C,Vester H,Schmitt A,Saidy-Rad S,Lin J,Neumaier M,Gillen S,Kleeff J,Friess H,Burkhart J,Stöckle U,Nüssler AK

Thu Mar 08 00:00:00 EST 2012

Flemingia macrophylla Extract Ameliorates Experimental Osteoporosis in Ovariectomized Rats.

Evidence-based complementary and alternative medicine : eCAM

Ho HY,Wu JB,Lin WC

Thu Aug 23 00:00:00 EDT 2012

Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.

PloS one

Zou Z,Chastain A,Moir S,Ford J,Trandem K,Martinelli E,Cicala C,Crocker P,Arthos J,Sun PD

Fri Jun 08 00:00:00 EDT 2012

Differentiation and glucocorticoid regulated apopto-phagocytic gene expression patterns in human macrophages. Role of Mertk in enhanced phagocytosis.

PloS one

Zahuczky G,Kristóf E,Majai G,Fésüs L

Wed Nov 02 00:00:00 EDT 2011

Minocycline inhibition of monocyte activation correlates with neuronal protection in SIV neuroAIDS.

PloS one

Campbell JH,Burdo TH,Autissier P,Bombardier JP,Westmoreland SV,Soulas C,González RG,Ratai EM,Williams KC

Wed Apr 06 00:00:00 EDT 2011

Evaluation of transduction efficiency in macrophage colony-stimulating factor differentiated human macrophages using HIV-1 based lentiviral vectors.

BMC biotechnology

Leyva FJ,Anzinger JJ,McCoy JP,Kruth HS

Mon Jan 31 00:00:00 EST 2011

Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.

The Journal of biological chemistry

Ehlting C,Ronkina N,Böhmer O,Albrecht U,Bode KA,Lang KS,Kotlyarov A,Radzioch D,Gaestel M,Häussinger D,Bode JG

Fri Jul 08 00:00:00 EDT 2011

Increased IL-10 mRNA expression in tumor-associated macrophage correlated with late stage of lung cancer.

Journal of experimental & clinical cancer research : CR

Wang R,Lu M,Zhang J,Chen S,Luo X,Qin Y,Chen H

Fri May 20 00:00:00 EDT 2011

Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages.

Retrovirology

Mwimanzi P,Hasan Z,Hassan R,Suzu S,Takiguchi M,Ueno T

Wed Jun 22 00:00:00 EDT 2011

Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5.

The Journal of biological chemistry

Song C,Rahim RT,Davey PC,Bednar F,Bardi G,Zhang L,Zhang N,Oppenheim JJ,Rogers TJ

Fri Jun 10 00:00:00 EDT 2011

Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis.

PloS one

Kakazu E,Ueno Y,Kondo Y,Inoue J,Ninomiya M,Kimura O,Wakui Y,Fukushima K,Tamai K,Shimosegawa T

Wed Feb 15 00:00:00 EST 2012

The transient receptor potential ion channel TRPV6 is expressed at low levels in osteoblasts and has little role in osteoblast calcium uptake.

PloS one

Little R,Muimo R,Robson L,Harris K,Grabowski PS

Fri May 11 00:00:00 EDT 2012

HIV infection enhances TRAIL-induced cell death in macrophage by down-regulating decoy receptor expression and generation of reactive oxygen species.

PloS one

Zhu DM,Shi J,Liu S,Liu Y,Zheng D

Tue Apr 05 00:00:00 EDT 2011

Dysfunctional CFTR alters the bactericidal activity of human macrophages against Pseudomonas aeruginosa.

PloS one

Del Porto P,Cifani N,Guarnieri S,Di Domenico EG,Mariggiò MA,Spadaro F,Guglietta S,Anile M,Venuta F,Quattrucci S,Ascenzioni F

Mon Oct 17 00:00:00 EDT 2011

Genomic stability over 9 years of an isoniazid resistant Mycobacterium tuberculosis outbreak strain in Sweden.

PloS one

Sandegren L,Groenheit R,Koivula T,Ghebremichael S,Advani A,Castro E,Pennhag A,Hoffner S,Mazurek J,Pawlowski A,Kan B,Bruchfeld J,Melefors Ö,Källenius G

Mon Jan 31 00:00:00 EST 2011

IRF5 is required for late-phase TNF secretion by human dendritic cells.

Blood

Krausgruber T,Saliba D,Ryzhakov G,Lanfrancotti A,Blazek K,Udalova IA

Thu Jun 03 00:00:00 EDT 2010

Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents.

The Journal of clinical investigation

Hakuno D,Kimura N,Yoshioka M,Mukai M,Kimura T,Okada Y,Yozu R,Shukunami C,Hiraki Y,Kudo A,Ogawa S,Fukuda K

Thu Jul 01 00:00:00 EDT 2010

IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling.

Proceedings of the National Academy of Sciences of the United States of America

Chen J,Ivashkiv LB

Tue Nov 09 00:00:00 EST 2010

Important roles of PI3Kgamma in osteoclastogenesis and bone homeostasis.

Proceedings of the National Academy of Sciences of the United States of America

Kang H,Chang W,Hurley M,Vignery A,Wu D

Tue Jul 20 00:00:00 EDT 2010

PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.

Proceedings of the National Academy of Sciences of the United States of America

Hou X,Kumar A,Lee C,Wang B,Arjunan P,Dong L,Maminishkis A,Tang Z,Li Y,Zhang F,Zhang SZ,Wardega P,Chakrabarty S,Liu B,Wu Z,Colosi P,Fariss RN,Lennartsson J,Nussenblatt R,Gutkind JS,Cao Y,Li X

Tue Jul 06 00:00:00 EDT 2010

Effective, broad spectrum control of virulent bacterial infections using cationic DNA liposome complexes combined with bacterial antigens.

PLoS pathogens

Ireland R,Olivares-Zavaleta N,Warawa JM,Gherardini FC,Jarrett C,Hinnebusch BJ,Belisle JT,Fairman J,Bosio CM

Thu May 27 00:00:00 EDT 2010

Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing.

Stem cells (Dayton, Ohio)

Zhang QZ,Su WR,Shi SH,Wilder-Smith P,Xiang AP,Wong A,Nguyen AL,Kwon CW,Le AD

Fri Oct 01 00:00:00 EDT 2010

Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy.

Arthritis research & therapy

Quan LD,Purdue PE,Liu XM,Boska MD,Lele SM,Thiele GM,Mikuls TR,Dou H,Goldring SR,Wang D

Thu Mar 31 00:00:00 EDT 2011

Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1.

Journal of immunology (Baltimore, Md. : 1950)

Foldi J,Chung AY,Xu H,Zhu J,Outtz HH,Kitajewski J,Li Y,Hu X,Ivashkiv LB

Mon Nov 01 00:00:00 EDT 2010

Matrix architecture dictates three-dimensional migration modes of human macrophages: differential involvement of proteases and podosome-like structures.

Journal of immunology (Baltimore, Md. : 1950)

Van Goethem E,Poincloux R,Gauffre F,Maridonneau-Parini I,Le Cabec V

Fri Jan 15 00:00:00 EST 2010

Phagocytosis of apoptotic cells by neutrophil granulocytes: diminished proinflammatory neutrophil functions in the presence of apoptotic cells.

Journal of immunology (Baltimore, Md. : 1950)

Esmann L,Idel C,Sarkar A,Hellberg L,Behnen M,Möller S,van Zandbergen G,Klinger M,Köhl J,Bussmeyer U,Solbach W,Laskay T

Fri Jan 01 00:00:00 EST 2010

Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein alpha.

Journal of immunology (Baltimore, Md. : 1950)

Zhang Y,Ma X

Thu Apr 01 00:00:00 EDT 2010

CXC chemokine ligand 4 induces a unique transcriptome in monocyte-derived macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Gleissner CA,Shaked I,Little KM,Ley K

Sat May 01 00:00:00 EDT 2010

Suppression of TNF-α and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27.

Journal of immunology (Baltimore, Md. : 1950)

Kalliolias GD,Gordon RA,Ivashkiv LB

Wed Dec 01 00:00:00 EST 2010

Calcium-activated pathways and oxidative burst mediate zymosan-induced signaling and IL-10 production in human macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Kelly EK,Wang L,Ivashkiv LB

Sat May 15 00:00:00 EDT 2010

HIV-1 Nef triggers macrophage fusion in a p61Hck- and protease-dependent manner.

Journal of immunology (Baltimore, Md. : 1950)

Vérollet C,Zhang YM,Le Cabec V,Mazzolini J,Charrière G,Labrousse A,Bouchet J,Medina I,Biessen E,Niedergang F,Bénichou S,Maridonneau-Parini I

Tue Jun 15 00:00:00 EDT 2010

Tumor-conditioned macrophages secrete migration-stimulating factor: a new marker for M2-polarization, influencing tumor cell motility.

Journal of immunology (Baltimore, Md. : 1950)

Solinas G,Schiarea S,Liguori M,Fabbri M,Pesce S,Zammataro L,Pasqualini F,Nebuloni M,Chiabrando C,Mantovani A,Allavena P

Thu Jul 01 00:00:00 EDT 2010

Direct inhibition of human RANK+ osteoclast precursors identifies a homeostatic function of IL-1beta.

Journal of immunology (Baltimore, Md. : 1950)

Lee B,Kim TH,Jun JB,Yoo DH,Woo JH,Choi SJ,Lee YH,Song GG,Sohn J,Park-Min KH,Ivashkiv LB,Ji JD

Mon Nov 15 00:00:00 EST 2010

Innate immune proteins C1q and mannan-binding lectin enhance clearance of atherogenic lipoproteins by human monocytes and macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Fraser DA,Tenner AJ

Fri Oct 01 00:00:00 EDT 2010

The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate.

Journal of immunology (Baltimore, Md. : 1950)

James DE,Nestor BJ,Sculco TP,Ivashkiv LB,Ross FP,Goldring SR,Purdue PE

Thu Jul 15 00:00:00 EDT 2010

miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation.

Journal of immunology (Baltimore, Md. : 1950)

Jurkin J,Schichl YM,Koeffel R,Bauer T,Richter S,Konradi S,Gesslbauer B,Strobl H

Sat May 01 00:00:00 EDT 2010

The chemorepellent Slit3 promotes monocyte migration.

Journal of immunology (Baltimore, Md. : 1950)

Geutskens SB,Hordijk PL,van Hennik PB

Wed Dec 15 00:00:00 EST 2010

Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin.

The Journal of biological chemistry

Yang Z,Philips JD,Doty RT,Giraudi P,Ostrow JD,Tiribelli C,Smith A,Abkowitz JL

Fri Sep 10 00:00:00 EDT 2010

Bone is not essential for osteoclast activation.

PloS one

Fuller K,Ross JL,Szewczyk KA,Moss R,Chambers TJ

Fri Sep 17 00:00:00 EDT 2010

VEGF stimulates RCAN1.4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-delta.

PloS one

Holmes K,Chapman E,See V,Cross MJ

Tue Jul 06 00:00:00 EDT 2010

Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival.

The Journal of biological chemistry

Lapierre DM,Tanabe N,Pereverzev A,Spencer M,Shugg RP,Dixon SJ,Sims SM

Fri Aug 13 00:00:00 EDT 2010

Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum.

PloS one

Curnow SJ,Fairclough M,Schmutz C,Kissane S,Denniston AK,Nash K,Buckley CD,Lord JM,Salmon M

Thu Mar 18 00:00:00 EDT 2010

Transcriptome analysis of monocyte-HIV interactions.

Retrovirology

Van den Bergh R,Florence E,Vlieghe E,Boonefaes T,Grooten J,Houthuys E,Tran HT,Gali Y,De Baetselier P,Vanham G,Raes G

Mon Jun 14 00:00:00 EDT 2010

Amorphigenin inhibits Osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells.

Anatomy & cell biology

Kim BG,Kwak HB,Choi EY,Kim HS,Kim MH,Kim SH,Choi MK,Chun CH,Oh J,Kim JJ

Wed Dec 01 00:00:00 EST 2010

Hematopoietic differentiation: a coordinated dynamical process towards attractor stable states.

BMC systems biology

Felli N,Cianetti L,Pelosi E,Carè A,Liu CG,Calin GA,Rossi S,Peschle C,Marziali G,Giuliani A

Wed Jun 16 00:00:00 EDT 2010

Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms.

The Journal of biological chemistry

Thielen BK,McNevin JP,McElrath MJ,Hunt BV,Klein KC,Lingappa JR

Fri Sep 03 00:00:00 EDT 2010

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.

Immunity

Zhong B,Zhang L,Lei C,Li Y,Mao AP,Yang Y,Wang YY,Zhang XL,Shu HB

Fri Mar 20 00:00:00 EDT 2009

Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion.

Cancer cell

Wu Y,Deng J,Rychahou PG,Qiu S,Evers BM,Zhou BP

Tue May 05 00:00:00 EDT 2009

The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth.

Blood

Pennisi A,Ling W,Li X,Khan S,Shaughnessy JD,Barlogie B,Yaccoby S

Thu Aug 27 00:00:00 EDT 2009

ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency.

Blood

Sauer AV,Mrak E,Hernandez RJ,Zacchi E,Cavani F,Casiraghi M,Grunebaum E,Roifman CM,Cervi MC,Ambrosi A,Carlucci F,Roncarolo MG,Villa A,Rubinacci A,Aiuti A

Thu Oct 08 00:00:00 EDT 2009

Cell adhesion through alphaV-containing integrins is required for efficient HIV-1 infection in macrophages.

Blood

Ballana E,Pauls E,Senserrich J,Clotet B,Perron-Sierra F,Tucker GC,Esté JA

Thu Feb 05 00:00:00 EST 2009

Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.

Blood

Kandilci A,Grosveld GC

Thu Aug 20 00:00:00 EDT 2009

Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease.

Blood

Kukreja A,Radfar S,Sun BH,Insogna K,Dhodapkar MV

Thu Oct 15 00:00:00 EDT 2009

Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism.

Blood

Secchiero P,Melloni E,di Iasio MG,Tiribelli M,Rimondi E,Corallini F,Gattei V,Zauli G

Thu Apr 30 00:00:00 EDT 2009

cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand.

Blood

Dupoux A,Cartier J,Cathelin S,Filomenko R,Solary E,Dubrez-Daloz L

Thu Jan 01 00:00:00 EST 2009

Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions.

The Journal of clinical investigation

Buono C,Anzinger JJ,Amar M,Kruth HS

Fri May 01 00:00:00 EDT 2009

A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.

Proceedings of the National Academy of Sciences of the United States of America

Ranatunga D,Hedrich CM,Wang F,McVicar DW,Nowak N,Joshi T,Feigenbaum L,Grant LR,Stäger S,Bream JH

Tue Oct 06 00:00:00 EDT 2009

The role of transposable elements in the regulation of IFN-lambda1 gene expression.

Proceedings of the National Academy of Sciences of the United States of America

Thomson SJ,Goh FG,Banks H,Krausgruber T,Kotenko SV,Foxwell BM,Udalova IA

Tue Jul 14 00:00:00 EDT 2009

A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections.

PLoS pathogens

Eberl M,Roberts GW,Meuter S,Williams JD,Topley N,Moser B

Sun Feb 01 00:00:00 EST 2009

Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Platzer B,Richter S,Kneidinger D,Waltenberger D,Woisetschläger M,Strobl H

Wed Jul 01 00:00:00 EDT 2009

Identification of mycobacterial alpha-glucan as a novel ligand for DC-SIGN: involvement of mycobacterial capsular polysaccharides in host immune modulation.

Journal of immunology (Baltimore, Md. : 1950)

Geurtsen J,Chedammi S,Mesters J,Cot M,Driessen NN,Sambou T,Kakutani R,Ummels R,Maaskant J,Takata H,Baba O,Terashima T,Bovin N,Vandenbroucke-Grauls CM,Nigou J,Puzo G,Lemassu A,Daffé M,Appelmelk BJ

Thu Oct 15 00:00:00 EDT 2009

Differential use of CARD9 by dectin-1 in macrophages and dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Goodridge HS,Shimada T,Wolf AJ,Hsu YM,Becker CA,Lin X,Underhill DM

Thu Jan 15 00:00:00 EST 2009

GM-CSF regulates fusion of mononuclear osteoclasts into bone-resorbing osteoclasts by activating the Ras/ERK pathway.

Journal of immunology (Baltimore, Md. : 1950)

Lee MS,Kim HS,Yeon JT,Choi SW,Chun CH,Kwak HB,Oh J

Tue Sep 01 00:00:00 EDT 2009

Interactions between human NK cells and macrophages in response to Salmonella infection.

Journal of immunology (Baltimore, Md. : 1950)

Lapaque N,Walzer T,Méresse S,Vivier E,Trowsdale J

Wed Apr 01 00:00:00 EDT 2009

Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.

Journal of immunology (Baltimore, Md. : 1950)

Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B

Sat Aug 01 00:00:00 EDT 2009

IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression.

Journal of immunology (Baltimore, Md. : 1950)

Park-Min KH,Ji JD,Antoniv T,Reid AC,Silver RB,Humphrey MB,Nakamura M,Ivashkiv LB

Sat Aug 15 00:00:00 EDT 2009

Differential expression of adenosine A3 receptors controls adenosine A2A receptor-mediated inhibition of TLR responses in microglia.

Journal of immunology (Baltimore, Md. : 1950)

van der Putten C,Zuiderwijk-Sick EA,van Straalen L,de Geus ED,Boven LA,Kondova I,IJzerman AP,Bajramovic JJ

Mon Jun 15 00:00:00 EDT 2009

Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts.

PloS one

Pilling D,Fan T,Huang D,Kaul B,Gomer RH

Fri Oct 16 00:00:00 EDT 2009

Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis.

The Journal of biological chemistry

Lee Y,Ha J,Kim HJ,Kim YS,Chang EJ,Song WJ,Kim HH

Fri Nov 27 00:00:00 EST 2009

Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling.

The Journal of biological chemistry

Lee JH,Kim HN,Yang D,Jung K,Kim HM,Kim HH,Ha H,Lee ZH

Fri May 15 00:00:00 EDT 2009

Breast cancer-derived factors stimulate osteoclastogenesis through the Ca2+/protein kinase C and transforming growth factor-beta/MAPK signaling pathways.

The Journal of biological chemistry

Tiedemann K,Hussein O,Sadvakassova G,Guo Y,Siegel PM,Komarova SV

Fri Nov 27 00:00:00 EST 2009

Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways.

Immunity

Hu X,Chung AY,Wu I,Foldi J,Chen J,Ji JD,Tateya T,Kang YJ,Han J,Gessler M,Kageyama R,Ivashkiv LB

Fri Nov 14 00:00:00 EST 2008

Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.

Blood

Spiegl N,Didichenko S,McCaffery P,Langen H,Dahinden CA

Sat Nov 01 00:00:00 EDT 2008

Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-gamma via superinduction of ATF-3 and suppression of AP-1.

Journal of immunology (Baltimore, Md. : 1950)

Ho HH,Antoniv TT,Ji JD,Ivashkiv LB

Wed Oct 01 00:00:00 EDT 2008

The angiogenic response of the aorta to injury and inflammatory cytokines requires macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Gelati M,Aplin AC,Fogel E,Smith KD,Nicosia RF

Wed Oct 15 00:00:00 EDT 2008

Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.

Journal of immunology (Baltimore, Md. : 1950)

Sacre SM,Lo A,Gregory B,Simmonds RE,Williams L,Feldmann M,Brennan FM,Foxwell BM

Mon Dec 01 00:00:00 EST 2008

Induction of TRAIL- and TNF-alpha-dependent apoptosis in human monocyte-derived dendritic cells by microfilariae of Brugia malayi.

Journal of immunology (Baltimore, Md. : 1950)

Semnani RT,Venugopal PG,Mahapatra L,Skinner JA,Meylan F,Chien D,Dorward DW,Chaussabel D,Siegel RM,Nutman TB

Sat Nov 15 00:00:00 EST 2008

Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.

Journal of immunology (Baltimore, Md. : 1950)

Mori Y,Tsuji S,Inui M,Sakamoto Y,Endo S,Ito Y,Fujimura S,Koga T,Nakamura A,Takayanagi H,Itoi E,Takai T

Wed Oct 01 00:00:00 EDT 2008

Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.

Journal of immunology (Baltimore, Md. : 1950)

Mori Y,Tsuji S,Inui M,Sakamoto Y,Endo S,Ito Y,Fujimura S,Koga T,Nakamura A,Takayanagi H,Itoi E,Takai T

Wed Oct 01 00:00:00 EDT 2008

SOCS1 regulates the IFN but not NFkappaB pathway in TLR-stimulated human monocytes and macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Prêle CM,Woodward EA,Bisley J,Keith-Magee A,Nicholson SE,Hart PH

Mon Dec 01 00:00:00 EST 2008

Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis.

The Journal of biological chemistry

Yang M,Mailhot G,Birnbaum MJ,MacKay CA,Mason-Savas A,Odgren PR

Fri Aug 18 00:00:00 EDT 2006

MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation.

The Journal of biological chemistry

Kim MS,Day CJ,Morrison NA

Fri Apr 22 00:00:00 EDT 2005

Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.

Blood

Rusnati M,Camozzi M,Moroni E,Bottazzi B,Peri G,Indraccolo S,Amadori A,Mantovani A,Presta M

Thu Jul 01 00:00:00 EDT 2004

Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.

Blood

Rusnati M,Camozzi M,Moroni E,Bottazzi B,Peri G,Indraccolo S,Amadori A,Mantovani A,Presta M

Thu Jul 01 00:00:00 EDT 2004

Disabling of receptor activator of nuclear factor-kappaB (RANK) receptor complex by novel osteoprotegerin-like peptidomimetics restores bone loss in vivo.

The Journal of biological chemistry

Cheng X,Kinosaki M,Takami M,Choi Y,Zhang H,Murali R

Fri Feb 27 00:00:00 EST 2004

c-myc is required for osteoclast differentiation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Battaglino R,Kim D,Fu J,Vaage B,Fu XY,Stashenko P

300-25 was used in Cell Culture to demonstrate role of c-myc as a downstream target of RANKL involved in RANKL-induced osteoclastogenesis.

Wed May 01 00:00:00 EDT 2002

Bioinformatics

Protein Aliases: colony stimulating factor 1 (macrophage); CSF-1; H-MCSF; Lanimostim; M-MCSF; macrophage colony stimulating factor 1; Macrophage colony-stimulating factor 1; MGC31930; PG-M-CSF; Proteoglycan macrophage colony-stimulating factor

Human M-CSF Recombinant Protein, PeproTech®

Human M-CSF Protein (300-25-10UG) in Functional

Product Details

300-25-10UG

Western Blot (WB)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

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Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

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Contains

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Bioinformatics

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