Product References
Generation of Genome-Edited Chicken Through Targeting of Primordial Germ Cells.
Methods in molecular biology (Clifton, N.J.)
Idoko-Akoh A,McGrew MJ
120-14 was used in Cell Culture to describe materials and protocols for performing heritable genome editing in the chicken through targeting of in vitro propagated chicken primordial germ cells.
Mon Apr 03 00:00:00 EDT 2023
Rat post-implantation epiblast-derived pluripotent stem cells produce functional germ cells.
Cell reports methods
Iwatsuki K,Oikawa M,Kobayashi H,Penfold CA,Sanbo M,Yamamoto T,Hochi S,Kurimoto K,Hirabayashi M,Kobayashi T
120-14 was used in In vitro experiments to demonstrate that rat EpiSCs retain competency to produce authentic primordial germ cell-like cells that undergo functional gametogenesis leading to the birth of viable offspring.
Mon Aug 28 00:00:00 EDT 2023
Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling.
Scientific reports
Shono M,Kishimoto K,Hikabe O,Hayashi M,Semi K,Takashima Y,Sasaki E,Kato K,Hayashi K
120-14 was used in In vitro experiments to identify PDPN and KIT as surface marker proteins by which PGCLCs can be isolated from embryonic stem cells without genetic manipulation.
Thu Feb 23 00:00:00 EST 2023
Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling.
Scientific reports
Shono M,Kishimoto K,Hikabe O,Hayashi M,Semi K,Takashima Y,Sasaki E,Kato K,Hayashi K
120-14 was used in In vitro experiments to identify PDPN and KIT as surface marker proteins by which PGCLCs can be isolated from embryonic stem cells without genetic manipulation.
Thu Feb 23 00:00:00 EST 2023
Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC.
Journal of neurochemistry
Ateaque S,Merkouris S,Wyatt S,Allen ND,Xie J,DiStefano PS,Lindsay RM,Barde YA
120-14 was used in Sample Preparation (Western Blotting) to study Trk activation by brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) in neurons differentiated from human embryonic stem cells expressing both TrkB and TrkC.
Wed Jun 01 00:00:00 EDT 2022
Dextran sulfate prevents excess aggregation of human pluripotent stem cells in 3D culture by inhibiting ICAM1 expression coupled with down-regulating E-cadherin through activating the Wnt signaling pathway.
Stem cell research & therapy
Wu H,Tang X,Wang Y,Wang N,Chen Q,Xie J,Liu S,Zhong Z,Qiu Y,Situ P,Zern MA,Wang J,Chen H,Duan Y
120-14 was used in Cell Culture to demonstrate a significant step toward developing the expansion of Human pluripotent stem cells (hPSCs) under 3D suspension condition in large-scale cultures. The study played an important role in controlling the size of hPSC aggregates in 3D suspension culture by inhibiting the expression of ICAM1 coupled with the down-regulation of E-cad through the activation of the Wnt signaling pathway.
Thu May 26 00:00:00 EDT 2022
Derivation of Three-Dimensional Human Induced Pluripotent Stem Cell-Derived Vocal Fold Mucosa for Clinical and Pharmacological Applications.
Methods in molecular biology (Clifton, N.J.)
Lungova V,Thibeault SL
120-14 was used in Cell Culture to describe in vitro developmental differentiation of human induced pluripotent stem cells into vocal fold basal epithelial progenitors that were reseeded on collagen-fibroblast constructs to induce stratification and generate a three-dimensional model of human vocal fold mucosa which can be used as a tool for disease modeling and testing of therapeutic approaches for the treatment of laryngeal and VF inflammation.
Thu Jun 23 00:00:00 EDT 2022
Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition.
Nucleic acids research
Quan Y,Wang M,Xu C,Wang X,Wu Y,Qin D,Lin Y,Lu X,Lu F,Li L
120-14 was used in Cell Culture to suggest that Cnot8 eliminates naïve regulation networks through mRNA clearance, and is essential for naïve-to-formative pluripotency transition.
Fri May 06 00:00:00 EDT 2022
Optimized protocol to derive germline stem-cell-like cells from mouse pluripotent stem cells.
STAR protocols
Ishikura Y,Ohta H,Nagano M,Saitou M
120-14 was used in In vitro experiments to present a step-by-step protocol for differentiation of mouse pluripotent stem cells (PSCs) into germline stem-cell-like cells (GSCLCs) via PGC-like cell and spermatogonium-like cell intermediates.
Fri Sep 16 00:00:00 EDT 2022
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens.
Cell stem cell
Karvas RM,Khan SA,Verma S,Yin Y,Kulkarni D,Dong C,Park KM,Chew B,Sane E,Fischer LA,Kumar D,Ma L,Boon ACM,Dietmann S,Mysorekar IU,Theunissen TW
120-14 was used in Cell Culture to demonstrate that SC-TOs exhibit selective vulnerability to emerging pathogens (SARS-CoV-2 and Zika virus), which correlates with expression levels of their respective entry factors.
Thu May 05 00:00:00 EDT 2022
Epithelial cell plasticity drives endoderm formation during gastrulation.
Nature cell biology
Scheibner K,Schirge S,Burtscher I,Büttner M,Sterr M,Yang D,Böttcher A,Irmler M,Beckers J,Cernilogar FM,Schotta G,Theis FJ,Lickert H
Thu Jul 01 00:00:00 EDT 2021
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.
Cell stem cell
Breunig M,Merkle J,Wagner M,Melzer MK,Barth TFE,Engleitner T,Krumm J,Wiedenmann S,Cohrs CM,Perkhofer L,Jain G,Krüger J,Hermann PC,Schmid M,Madácsy T,Varga Á,Griger J,Azoitei N,Müller M,Wessely O,Robey PG,Heller S,Dantes Z,Reichert M,Günes C,Bolenz C,Kuhn F,Maléth J,Speier S,Liebau S,Sipos B,Kuster B,Seufferlein T,Rad R,Meier M,Hohwieler M,Kleger A
120-14 was used in In vitro experiments to show that PDLOs enable in vitro and in vivo studies of pancreatic plasticity, dysplasia, and cancer formation from a genetically defined background.
Thu Jun 03 00:00:00 EDT 2021
A splicing factor switch controls hematopoietic lineage specification of pluripotent stem cells.
EMBO reports
Li Y,Wang D,Wang H,Huang X,Wen Y,Wang B,Xu C,Gao J,Liu J,Tong J,Wang M,Su P,Ren S,Ma F,Li HD,Bresnick EH,Zhou J,Shi L
Thu Jan 07 00:00:00 EST 2021
Doxorubicin-induced senescence promotes stemness and tumorigenicity in EpCAM-/CD133- nonstem cell population in hepatocellular carcinoma cell line, HuH-7.
Molecular oncology
Karabicici M,Alptekin S,Fırtına Karagonlar Z,Erdal E
Sun Aug 01 00:00:00 EDT 2021
Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition.
Stem cells (Dayton, Ohio)
Kanagaki S,Ikeo S,Suezawa T,Yamamoto Y,Seki M,Hirai T,Hagiwara M,Suzuki Y,Gotoh S
Mon Feb 01 00:00:00 EST 2021
OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human.
Nature communications
Huang X,Park KM,Gontarz P,Zhang B,Pan J,McKenzie Z,Fischer LA,Dong C,Dietmann S,Xing X,Shliaha PV,Yang J,Li D,Ding J,Lungjangwa T,Mitalipova M,Khan SA,Imsoonthornruksa S,Jensen N,Wang T,Kadoch C,Jaenisch R,Wang J,Theunissen TW
Thu Aug 26 00:00:00 EDT 2021
Differentiation of human pluripotent stem cells into pancreatic duct-like organoids.
STAR protocols
Breunig M,Merkle J,Melzer MK,Heller S,Seufferlein T,Meier M,Hohwieler M,Kleger A
120-14 was used in In vitro experiments to describe a scalable in vitro differentiation protocol to guide human pluripotent stem cells stepwise into pancreatic duct-like organoids.
Fri Dec 17 00:00:00 EST 2021
Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells.
Communications biology
Rore H,Owen N,Piña-Aguilar RE,Docherty K,Sekido R
Mon Jun 28 00:00:00 EDT 2021
Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure.
iScience
Meseguer-Ripolles J,Lucendo-Villarin B,Tucker C,Ferreira-Gonzalez S,Homer N,Wang Y,Starkey Lewis PJ,M Toledo E,Mellado-Gomez E,Simpson J,Flint O,Jaiswal H,Beer NL,Karlsen AE,Forbes SJ,Dear JW,Hughes J,Hay DC
Fri Jun 25 00:00:00 EDT 2021
Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening.
Cell reports
Khan SA,Park KM,Fischer LA,Dong C,Lungjangwa T,Jimenez M,Casalena D,Chew B,Dietmann S,Auld DS,Jaenisch R,Theunissen TW
Tue Jun 15 00:00:00 EDT 2021
The embryonic ontogeny of the gonadal somatic cells in mice and monkeys.
Cell reports
Sasaki K,Oguchi A,Cheng K,Murakawa Y,Okamoto I,Ohta H,Yabuta Y,Iwatani C,Tsuchiya H,Yamamoto T,Seita Y,Saitou M
Tue May 04 00:00:00 EDT 2021
Generation and trapping of a mesoderm biased state of human pluripotency.
Nature communications
Stavish D,Böiers C,Price C,Frith TJR,Halliwell J,Saldaña-Guerrero I,Wray J,Brown J,Carr J,James C,Barbaric I,Andrews PW,Enver T
Mon Oct 05 00:00:00 EDT 2020
hiPS-Derived Astroglia Model Shows Temporal Transcriptomic Profile Related to Human Neural Development and Glia Competence Acquisition of a Maturing Astrocytic Identity.
Advanced biosystems
Lundin A,Ricchiuto P,Clausen M,Hicks R,Falk A,Herland A
Fri May 01 00:00:00 EDT 2020
Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells.
Nature communications
Kishimoto K,Furukawa KT,Luz-Madrigal A,Yamaoka A,Matsuoka C,Habu M,Alev C,Zorn AM,Morimoto M
Thu Aug 27 00:00:00 EDT 2020
Derivation of trophoblast stem cells from naïve human pluripotent stem cells.
eLife
Dong C,Beltcheva M,Gontarz P,Zhang B,Popli P,Fischer LA,Khan SA,Park KM,Yoon EJ,Xing X,Kommagani R,Wang T,Solnica-Krezel L,Theunissen TW
120-14 was used in Cell Culture to find that naïve hPSCs can directly give rise to human trophoblast stem cells (hTSCs) and undergo further differentiation into both extravillous and syncytiotrophoblast.
Wed Feb 12 00:00:00 EST 2020
Treatment and Prevention of Lung Cancer Using a Virus-Infected Reprogrammed Somatic Cell-Derived Tumor Cell Vaccination (VIReST) Regime.
Frontiers in immunology
Zhang Z,Lu S,Dunmall LSC,Wang Z,Cheng Z,Zhang Z,Yan W,Chu Y,Gao D,Wang N,Li Y,Wang J,Li Y,Ji Y,Shan D,Li K,Wang P,Dong Y,Dong J,Lemoine NR,Pei D,Zhang L,Wang Y
120-14 was used in In vitro experiments to establish how a Virus-Infected Reprogrammed Somatic cell-derived Tumor cell (VIReST) vaccination regime can be utilised for treatment or prevention of lung cancer development in at-risk individuals.
Fri Apr 30 00:00:00 EDT 2021
IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche.
Nature communications
Wamaitha SE,Grybel KJ,Alanis-Lobato G,Gerri C,Ogushi S,McCarthy A,Mahadevaiah SK,Healy L,Lea RA,Molina-Arcas M,Devito LG,Elder K,Snell P,Christie L,Downward J,Turner JMA,Niakan KK
Fri Feb 07 00:00:00 EST 2020
Generation of human oogonia from induced pluripotent stem cells in culture.
Nature protocols
Yamashiro C,Sasaki K,Yokobayashi S,Kojima Y,Saitou M
120-14 was used in Cell Culture to describe a protocol to differentiate human induced pluripotent stem cells (hiPSCs) into oogonia in vitro and is suitable for investigating the mechanisms of hPGC specification and epigenetic reprogramming.
Wed Apr 01 00:00:00 EDT 2020
Deciphering the "m6A Code" via Antibody-Independent Quantitative Profiling.
Cell
Garcia-Campos MA,Edelheit S,Toth U,Safra M,Shachar R,Viukov S,Winkler R,Nir R,Lasman L,Brandis A,Hanna JH,Rossmanith W,Schwartz S
Thu Jul 25 00:00:00 EDT 2019
Reviving rare chicken breeds using genetically engineered sterility in surrogate host birds.
Proceedings of the National Academy of Sciences of the United States of America
Woodcock ME,Gheyas AA,Mason AS,Nandi S,Taylor L,Sherman A,Smith J,Burt DW,Hawken R,McGrew MJ
Tue Oct 15 00:00:00 EDT 2019
miR-193a/b-3p relieves hepatic fibrosis and restrains proliferation and activation of hepatic stellate cells.
Journal of cellular and molecular medicine
Ju B,Nie Y,Yang X,Wang X,Li F,Wang M,Wang C,Zhang H
Sat Jun 01 00:00:00 EDT 2019
Reprogrammed Cells Display Distinct Proteomic Signatures Associated with Colony Morphology Variability.
Stem cells international
Bjørlykke Y,Søviknes AM,Hoareau L,Vethe H,Mathisen AF,Chera S,Vaudel M,Ghila LM,Ræder H
120-14 was used in Sample Preparation (FC/FACS) to analyze and compare the proteome landscape of 20 reprogrammed cell lines classified as stable colony morphologies to find different defined patterns of colony morphology in reprogrammed cells which were associated with distinct proteomic profiles and different outcomes in differentiation capacity.
Thu Oct 01 00:00:00 EDT 2020
CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells.
Scientific reports
Hsu KS,Otsu W,Li Y,Wang HC,Chen S,Tsang SH,Chuang JZ,Sung CH
120-14 was used in In vitro experiments to demonstrate that CLIC4 is a novel matrix microenvironment modulator and a novel regulator for late endosomal cargo sorting. Moreover, the late endosomal sorting of MMP14 actively regulates its surface activation in RPE cells.
Thu Aug 22 00:00:00 EDT 2019
Investigation and Restoration of BEST1 Activity in Patient-derived RPEs with Dominant Mutations.
Scientific reports
Ji C,Li Y,Kittredge A,Hopiavuori A,Ward N,Yao P,Fukuda Y,Zhang Y,Tsang SH,Yang T
Fri Dec 13 00:00:00 EST 2019
Reprogramming Captures the Genetic and Tumorigenic Properties of Neurofibromatosis Type 1 Plexiform Neurofibromas.
Stem cell reports
Carrió M,Mazuelas H,Richaud-Patin Y,Gel B,Terribas E,Rosas I,Jimenez-Delgado S,Biayna J,Vendredy L,Blanco I,Castellanos E,Lázaro C,Raya Á,Serra E
Tue Feb 12 00:00:00 EST 2019
Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development.
Cell reports
Ishiuchi T,Ohishi H,Sato T,Kamimura S,Yorino M,Abe S,Suzuki A,Wakayama T,Suyama M,Sasaki H
120-14 was used in Cell Culture to conduct a forward genetic screen to identify regulators for extraembryonic development and identify Zfp281 as a key factor.
Tue May 07 00:00:00 EDT 2019
Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure.
Nature communications
Lungova V,Chen X,Wang Z,Kendziorski C,Thibeault SL
Tue Sep 24 00:00:00 EDT 2019
A change in the zinc ion concentration reflects the maturation of insulin-producing cells generated from adipose-derived mesenchymal stem cells.
Scientific reports
Ohta S,Ikemoto T,Wada Y,Saito Y,Yamada S,Imura S,Morine Y,Shimada M
Tue Dec 10 00:00:00 EST 2019
Functional Oocytes Derived from Granulosa Cells.
Cell reports
Tian C,Liu L,Ye X,Fu H,Sheng X,Wang L,Wang H,Heng D,Liu L
120-14 was used in Cell Culture to demonstrate that funtional oocytes posessing high genomic stability can be produced in vitro from somatic gPSCs through cellular reprogramming, facilitated by protonic sodium or acid - overall a safe and effective chemical induction technique.
Tue Dec 24 00:00:00 EST 2019
MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates.
Nature communications
Aron Badin R,Bugi A,Williams S,Vadori M,Michael M,Jan C,Nassi A,Lecourtois S,Blancher A,Cozzi E,Hantraye P,Perrier AL
Wed Sep 25 00:00:00 EDT 2019
The role of cardiac transcription factor NKX2-5 in regulating the human cardiac miRNAome.
Scientific reports
Arasaratnam D,Bell KM,Sim CB,Koutsis K,Anderson DJ,Qian EL,Stanley EG,Elefanty AG,Cheung MM,Oshlack A,White AJ,Abi Khalil C,Hudson JE,Porrello ER,Elliott DA
Mon Nov 04 00:00:00 EST 2019
UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells.
Scientific reports
Mesquitta WT,Wandsnider M,Kang H,Thomson J,Moskvin O,Suknuntha K,Slukvin II
Mon Apr 29 00:00:00 EDT 2019
Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome.
Nature communications
Zhu W,Zhang B,Li M,Mo F,Mi T,Wu Y,Teng Z,Zhou Q,Li W,Hu B
Mon Feb 25 00:00:00 EST 2019
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia.
Stem cell reports
Konttinen H,Cabral-da-Silva MEC,Ohtonen S,Wojciechowski S,Shakirzyanova A,Caligola S,Giugno R,Ishchenko Y,Hernández D,Fazaludeen MF,Eamen S,Budia MG,Fagerlund I,Scoyni F,Korhonen P,Huber N,Haapasalo A,Hewitt AW,Vickers J,Smith GC,Oksanen M,Graff C,Kanninen KM,Lehtonen S,Propson N,Schwartz MP,Pébay A,Koistinaho J,Ooi L,Malm T
Tue Oct 08 00:00:00 EDT 2019
MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1.
Stem cell reports
Wang H,Liu C,Liu X,Wang M,Wu D,Gao J,Su P,Nakahata T,Zhou W,Xu Y,Shi L,Ma F,Zhou J
Tue Feb 13 00:00:00 EST 2018
Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.
Nature communications
Buskin A,Zhu L,Chichagova V,Basu B,Mozaffari-Jovin S,Dolan D,Droop A,Collin J,Bronstein R,Mehrotra S,Farkas M,Hilgen G,White K,Pan KT,Treumann A,Hallam D,Bialas K,Chung G,Mellough C,Ding Y,Krasnogor N,Przyborski S,Zwolinski S,Al-Aama J,Alharthi S,Xu Y,Wheway G,Szymanska K,McKibbin M,Inglehearn CF,Elliott DJ,Lindsay S,Ali RR,Steel DH,Armstrong L,Sernagor E,Urlaub H,Pierce E,Lührmann R,Grellscheid SN,Johnson CA,Lako M
Fri Oct 12 00:00:00 EDT 2018
NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network.
Nature communications
Anderson DJ,Kaplan DI,Bell KM,Koutsis K,Haynes JM,Mills RJ,Phelan DG,Qian EL,Leitoguinho AR,Arasaratnam D,Labonne T,Ng ES,Davis RP,Casini S,Passier R,Hudson JE,Porrello ER,Costa MW,Rafii A,Curl CL,Delbridge LM,Harvey RP,Oshlack A,Cheung MM,Mummery CL,Petrou S,Elefanty AG,Stanley EG,Elliott DA
Tue Apr 10 00:00:00 EDT 2018
Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro.
Stem cell reports
Garcia-Alegria E,Menegatti S,Fadlullah MZH,Menendez P,Lacaud G,Kouskoff V
Tue Nov 13 00:00:00 EST 2018
TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency.
Stem cell reports
Tao Y,Yen MR,Chitiashvili T,Nakano H,Kim R,Hosohama L,Tan YC,Nakano A,Chen PY,Clark AT
Tue Jan 09 00:00:00 EST 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
Tue Oct 09 00:00:00 EDT 2018
Long-term expansion of alveolar stem cells derived from human iPS cells in organoids.
Nature methods
Yamamoto Y,Gotoh S,Korogi Y,Seki M,Konishi S,Ikeo S,Sone N,Nagasaki T,Matsumoto H,Muro S,Ito I,Hirai T,Kohno T,Suzuki Y,Mishima M
Wed Nov 01 00:00:00 EDT 2017
Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification.
Molecular cell
Hu D,Gao X,Cao K,Morgan MA,Mas G,Smith ER,Volk AG,Bartom ET,Crispino JD,Di Croce L,Shilatifard A
120-14 was used in Sample Preparation (FC/FACS) to analyse the contribution of MLL2’s methyltransferase and CXXC domain in H3K4 trimethylation in mouse embryonic stem cells.
Thu Feb 02 00:00:00 EST 2017
Efficacy and Safety of Immuno-Magnetically Sorted Smooth Muscle Progenitor Cells Derived from Human-Induced Pluripotent Stem Cells for Restoring Urethral Sphincter Function.
Stem cells translational medicine
Li Y,Green M,Wen Y,Wei Y,Wani P,Wang Z,Reijo Pera R,Chen B
Sat Apr 01 00:00:00 EDT 2017
C9ORF135 encodes a membrane protein whose expression is related to pluripotency in human embryonic stem cells.
Scientific reports
Zhou S,Liu Y,Ma Y,Zhang X,Li Y,Wen J
Mon Mar 27 00:00:00 EDT 2017
PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs.
Nature communications
Shan Y,Liang Z,Xing Q,Zhang T,Wang B,Tian S,Huang W,Zhang Y,Yao J,Zhu Y,Huang K,Liu Y,Wang X,Chen Q,Zhang J,Shang B,Li S,Shi X,Liao B,Zhang C,Lai K,Zhong X,Shu X,Wang J,Yao H,Chen J,Pei D,Pan G
Fri Sep 22 00:00:00 EDT 2017
PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs.
Nature communications
Shan Y,Liang Z,Xing Q,Zhang T,Wang B,Tian S,Huang W,Zhang Y,Yao J,Zhu Y,Huang K,Liu Y,Wang X,Chen Q,Zhang J,Shang B,Li S,Shi X,Liao B,Zhang C,Lai K,Zhong X,Shu X,Wang J,Yao H,Chen J,Pei D,Pan G
Fri Sep 22 00:00:00 EDT 2017
Cytoplasmic and Nuclear TAZ Exert Distinct Functions in Regulating Primed Pluripotency.
Stem cell reports
Zhou X,Chadarevian JP,Ruiz B,Ying QL
Tue Sep 12 00:00:00 EDT 2017
The transcription factor Gbx2 induces expression of Kruppel-like factor 4 to maintain and induce naïve pluripotency of embryonic stem cells.
The Journal of biological chemistry
Wang M,Tang L,Liu D,Ying QL,Ye S
Fri Oct 13 00:00:00 EDT 2017
Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells.
Stem cell reports
Yang J,Wang Y,Zhou T,Wong LY,Tian XY,Hong X,Lai WH,Au KW,Wei R,Liu Y,Cheng LH,Liang G,Huang Z,Fan W,Zhao P,Wang X,Ibañez DP,Luo Z,Li Y,Zhong X,Chen S,Wang D,Li L,Lai L,Qin B,Bao X,Hutchins AP,Siu CW,Huang Y,Esteban MA,Tse HF
Tue Mar 14 00:00:00 EDT 2017
Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration.
PloS one
Geng Z,Walsh PJ,Truong V,Hill C,Ebeling M,Kapphahn RJ,Montezuma SR,Yuan C,Roehrich H,Ferrington DA,Dutton JR
Thu Aug 17 00:00:00 EDT 2017
Naive-like ESRRB+ iPSCs with the Capacity for Rapid Neural Differentiation.
Stem cell reports
Kisa F,Shiozawa S,Oda K,Yoshimatsu S,Nakamura M,Koya I,Kawai K,Suzuki S,Okano H
Tue Dec 12 00:00:00 EST 2017
Naive-like ESRRB+ iPSCs with the Capacity for Rapid Neural Differentiation.
Stem cell reports
Kisa F,Shiozawa S,Oda K,Yoshimatsu S,Nakamura M,Koya I,Kawai K,Suzuki S,Okano H
Tue Dec 12 00:00:00 EST 2017
High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress.
Stem cells translational medicine
Thorne N,Malik N,Shah S,Zhao J,Class B,Aguisanda F,Southall N,Xia M,McKew JC,Rao M,Zheng W
120-14 was used in Cell Culture to develop as assay to identify compounds that protect against oxidative stress, a condition associated with many neurodegenerative diseases using astrocytes differentiated from human embryonic stem cells.
Sun May 01 00:00:00 EDT 2016
Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes.
Stem cell reports
Josowitz R,Mulero-Navarro S,Rodriguez NA,Falce C,Cohen N,Ullian EM,Weiss LA,Rauen KA,Sobie EA,Gelb BD
Tue Sep 13 00:00:00 EDT 2016
Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG).
Molecular & cellular proteomics : MCP
Thiesler CT,Cajic S,Hoffmann D,Thiel C,van Diepen L,Hennig R,Sgodda M,Weiβmann R,Reichl U,Steinemann D,Diekmann U,Huber NM,Oberbeck A,Cantz T,Kuss AW,Körner C,Schambach A,Rapp E,Buettner FF
Fri Apr 01 00:00:00 EDT 2016
PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency.
Stem cell reports
Okashita N,Suwa Y,Nishimura O,Sakashita N,Kadota M,Nagamatsu G,Kawaguchi M,Kashida H,Nakajima A,Tachibana M,Seki Y
Tue Dec 13 00:00:00 EST 2016
Xeno-Transplantation of macro-encapsulated islets and Pluripotent Stem Cell-Derived Pancreatic Progenitors without Immunosuppression.
Journal of stem cell and transplantation biology
Bukys MA,Bakos B,Afelik S,Zimmerman B,Barbaro B,Lin DL,Vaca P,Goldman T,Rotem A,Damaser M,Oberholzer J,Barkai U,Jensen J
120-14 was used in Cell Culture to investigate use of a device termed βAIR together with human embryonic stem cells in islet transplantation.
Wed Sep 21 00:00:00 EDT 2016
Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells.
Stem cell reports
Siller R,Greenhough S,Naumovska E,Sullivan GJ
Tue May 12 00:00:00 EDT 2015
The roles of ERAS during cell lineage specification of mouse early embryonic development.
Open biology
Zhao ZA,Yu Y,Ma HX,Wang XX,Lu X,Zhai Y,Zhang X,Wang H,Li L
120-14 was used in Cell Culture to show that ERAS may also play important roles in cell lineage specification during mouse early embryonic development.
Sat Aug 01 00:00:00 EDT 2015
Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential.
Proceedings of the National Academy of Sciences of the United States of America
Ohnuki M,Tanabe K,Sutou K,Teramoto I,Sawamura Y,Narita M,Nakamura M,Tokunaga Y,Nakamura M,Watanabe A,Yamanaka S,Takahashi K
Tue Aug 26 00:00:00 EDT 2014
Derivation of novel human ground state naive pluripotent stem cells.
Nature
Gafni O,Weinberger L,Mansour AA,Manor YS,Chomsky E,Ben-Yosef D,Kalma Y,Viukov S,Maza I,Zviran A,Rais Y,Shipony Z,Mukamel Z,Krupalnik V,Zerbib M,Geula S,Caspi I,Schneir D,Shwartz T,Gilad S,Amann-Zalcenstein D,Benjamin S,Amit I,Tanay A,Massarwa R,Novershtern N,Hanna JH
Thu Dec 12 00:00:00 EST 2013
Role of SOX17 in hematopoietic development from human embryonic stem cells.
Blood
Nakajima-Takagi Y,Osawa M,Oshima M,Takagi H,Miyagi S,Endoh M,Endo TA,Takayama N,Eto K,Toyoda T,Koseki H,Nakauchi H,Iwama A
Thu Jan 17 00:00:00 EST 2013
Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium.
PloS one
Zhu Y,Carido M,Meinhardt A,Kurth T,Karl MO,Ader M,Tanaka EM
Fri Sep 06 00:00:00 EDT 2013
Demarcation of stable subpopulations within the pluripotent hESC compartment.
PloS one
Bhatia S,Pilquil C,Roth-Albin I,Draper JS
Tue Aug 06 00:00:00 EDT 2013
The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.
Nature
Mansour AA,Gafni O,Weinberger L,Zviran A,Ayyash M,Rais Y,Krupalnik V,Zerbib M,Amann-Zalcenstein D,Maza I,Geula S,Viukov S,Holtzman L,Pribluda A,Canaani E,Horn-Saban S,Amit I,Novershtern N,Hanna JH
Thu Aug 16 00:00:00 EDT 2012
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Kajiwara M,Aoi T,Okita K,Takahashi R,Inoue H,Takayama N,Endo H,Eto K,Toguchida J,Uemoto S,Yamanaka S
Tue Jul 31 00:00:00 EDT 2012
Attenuation of extrinsic signaling reveals the importance of matrix remodeling on maintenance of embryonic stem cell self-renewal.
Proceedings of the National Academy of Sciences of the United States of America
Przybyla LM,Voldman J
Tue Jan 17 00:00:00 EST 2012
Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells.
Stem cells (Dayton, Ohio)
Mellough CB,Sernagor E,Moreno-Gimeno I,Steel DH,Lako M
Sun Apr 01 00:00:00 EDT 2012
Microfibrous substrate geometry as a critical trigger for organization, self-renewal, and differentiation of human embryonic stem cells within synthetic 3-dimensional microenvironments.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Carlson AL,Florek CA,Kim JJ,Neubauer T,Moore JC,Cohen RI,Kohn J,Grumet M,Moghe PV
Wed Aug 01 00:00:00 EDT 2012
The prolyl hydroxylase PHD3 identifies proinflammatory macrophages and its expression is regulated by activin A.
Journal of immunology (Baltimore, Md. : 1950)
Escribese MM,Sierra-Filardi E,Nieto C,Samaniego R,Sánchez-Torres C,Matsuyama T,Calderon-Gómez E,Vega MA,Salas A,Sánchez-Mateos P,Corbí AL
Wed Aug 15 00:00:00 EDT 2012
Redifferentiation of expanded human pancreatic β-cell-derived cells by inhibition of the NOTCH pathway.
The Journal of biological chemistry
Bar Y,Russ HA,Sintov E,Anker-Kitai L,Knoller S,Efrat S
Fri May 18 00:00:00 EDT 2012
Dedifferentiation of foetal CNS stem cells to mesendoderm-like cells through an EMT process.
PloS one
Ber S,Lee C,Voiculescu O,Surani MA
Mon Jun 04 00:00:00 EDT 2012
Reprogrammed keratinocytes from elderly type 2 diabetes patients suppress senescence genes to acquire induced pluripotency.
Aging
Ohmine S,Squillace KA,Hartjes KA,Deeds MC,Armstrong AS,Thatava T,Sakuma T,Terzic A,Kudva Y,Ikeda Y
Sun Jan 01 00:00:00 EST 2012
Improvement of carbon tetrachloride-induced acute hepatic failure by transplantation of induced pluripotent stem cells without reprogramming factor c-Myc.
International journal of molecular sciences
Chang HM,Liao YW,Chiang CH,Chen YJ,Lai YH,Chang YL,Chen HL,Jeng SY,Hsieh JH,Peng CH,Li HY,Chien Y,Chen SY,Chen LK,Huo TI
Mon Aug 31 00:00:00 EDT 2015
Activin A promotes neuronal differentiation of cerebrocortical neural progenitor cells.
PloS one
Rodríguez-Martínez G,Molina-Hernández A,Velasco I
Tue Jan 29 00:00:00 EST 2013
In vitro modeling of paraxial mesodermal progenitors derived from induced pluripotent stem cells.
PloS one
Sakurai H,Sakaguchi Y,Shoji E,Nishino T,Maki I,Sakai H,Hanaoka K,Kakizuka A,Sehara-Fujisawa A
Tue Apr 23 00:00:00 EDT 2013
In vitro modeling of paraxial mesodermal progenitors derived from induced pluripotent stem cells.
PloS one
Sakurai H,Sakaguchi Y,Shoji E,Nishino T,Maki I,Sakai H,Hanaoka K,Kakizuka A,Sehara-Fujisawa A
Tue Apr 23 00:00:00 EDT 2013
PTK7 marks the first human developmental EMT in vitro.
PloS one
Chan DN,Azghadi SF,Feng J,Lowry WE
Mon Jun 24 00:00:00 EDT 2013
Human chondrogenic paraxial mesoderm, directed specification and prospective isolation from pluripotent stem cells.
Scientific reports
Umeda K,Zhao J,Simmons P,Stanley E,Elefanty A,Nakayama N
Mon Feb 25 00:00:00 EST 2013
TGFbeta family members are key mediators in the induction of myofibroblast phenotype of human adipose tissue progenitor cells by macrophages.
PloS one
Bourlier V,Sengenès C,Zakaroff-Girard A,Decaunes P,Wdziekonski B,Galitzky J,Villageois P,Esteve D,Chiotasso P,Dani C,Bouloumié A
Mon Jun 18 00:00:00 EDT 2012
Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells.
Cell
Hayashi K,Ohta H,Kurimoto K,Aramaki S,Saitou M
Fri Aug 19 00:00:00 EDT 2011
A poised chromatin platform for TGF-β access to master regulators.
Cell
Xi Q,Wang Z,Zaromytidou AI,Zhang XH,Chow-Tsang LF,Liu JX,Kim H,Barlas A,Manova-Todorova K,Kaartinen V,Studer L,Mark W,Patel DJ,Massagué J
Fri Dec 23 00:00:00 EST 2011
Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.
Nature protocols
Stacpoole SR,Bilican B,Webber DJ,Luzhynskaya A,He XL,Compston A,Karadottir R,Franklin RJ,Chandran S
Thu Jul 28 00:00:00 EDT 2011
Histone variant macroH2A confers resistance to nuclear reprogramming.
The EMBO journal
Pasque V,Gillich A,Garrett N,Gurdon JB
120-14 was used in Cell Culture to study restriction of somatic cell nuclear reprogramming by investigating the mechanisms that restrict reprogramming following nuclear transfer by assessing the stability of the inactive X chromosome (Xi) in different stages of inactivation.
Fri May 06 00:00:00 EDT 2011
SNW1 is a critical regulator of spatial BMP activity, neural plate border formation, and neural crest specification in vertebrate embryos.
PLoS biology
Wu MY,Ramel MC,Howell M,Hill CS
Tue Feb 15 00:00:00 EST 2011
Molecular and functional characterizations of gastrula organizer cells derived from human embryonic stem cells.
Stem cells (Dayton, Ohio)
Sharon N,Mor I,Golan-lev T,Fainsod A,Benvenisty N
Fri Apr 01 00:00:00 EDT 2011
Inducible cassette exchange: a rapid and efficient system enabling conditional gene expression in embryonic stem and primary cells.
Stem cells (Dayton, Ohio)
Iacovino M,Bosnakovski D,Fey H,Rux D,Bajwa G,Mahen E,Mitanoska A,Xu Z,Kyba M
Sat Oct 01 00:00:00 EDT 2011
CD24: a novel surface marker for PDX1-positive pancreatic progenitors derived from human embryonic stem cells.
Stem cells (Dayton, Ohio)
Jiang W,Sui X,Zhang D,Liu M,Ding M,Shi Y,Deng H
Fri Apr 01 00:00:00 EDT 2011
Changes in glycosphingolipid composition during differentiation of human embryonic stem cells to ectodermal or endodermal lineages.
Stem cells (Dayton, Ohio)
Liang YJ,Yang BC,Chen JM,Lin YH,Huang CL,Cheng YY,Hsu CY,Khoo KH,Shen CN,Yu J
Thu Dec 01 00:00:00 EST 2011
A genetic strategy for combined screening and localized imaging of breast cancer.
Molecular imaging and biology
Warram JM,Borovjagin AV,Zinn KR
Wed Jun 01 00:00:00 EDT 2011
Physical passaging of embryoid bodies generated from human pluripotent stem cells.
PloS one
Son MY,Kim HJ,Kim MJ,Cho YS
Tue May 03 00:00:00 EDT 2011
Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes.
Stem cell reviews and reports
Funakoshi N,Duret C,Pascussi JM,Blanc P,Maurel P,Daujat-Chavanieu M,Gerbal-Chaloin S
Thu Sep 01 00:00:00 EDT 2011
Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro.
PloS one
Russ HA,Sintov E,Anker-Kitai L,Friedman O,Lenz A,Toren G,Farhy C,Pasmanik-Chor M,Oron-Karni V,Ravassard P,Efrat S
Mon Mar 05 00:00:00 EST 2012
Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension.
Nature biotechnology
Steiner D,Khaner H,Cohen M,Even-Ram S,Gil Y,Itsykson P,Turetsky T,Idelson M,Aizenman E,Ram R,Berman-Zaken Y,Reubinoff B
Thu Apr 01 00:00:00 EDT 2010
Characterization of gastrulation-stage progenitor cells and their inhibitory crosstalk in human embryoid bodies.
Stem cells (Dayton, Ohio)
Kopper O,Giladi O,Golan-Lev T,Benvenisty N
Fri Jan 01 00:00:00 EST 2010
Neural induction intermediates exhibit distinct roles of Fgf signaling.
Stem cells (Dayton, Ohio)
Sterneckert J,Stehling M,Bernemann C,Araúzo-Bravo MJ,Greber B,Gentile L,Ortmeier C,Sinn M,Wu G,Ruau D,Zenke M,Brintrup R,Klein DC,Ko K,Schöler HR
Fri Oct 01 00:00:00 EDT 2010
An ES-like pluripotent state in FGF-dependent murine iPS cells.
PloS one
Di Stefano B,Buecker C,Ungaro F,Prigione A,Chen HH,Welling M,Eijpe M,Mostoslavsky G,Tesar P,Adjaye J,Geijsen N,Broccoli V
Thu Dec 30 00:00:00 EST 2010
Generation of homogeneous PDX1(+) pancreatic progenitors from human ES cell-derived endoderm cells.
Journal of molecular cell biology
Cai J,Yu C,Liu Y,Chen S,Guo Y,Yong J,Lu W,Ding M,Deng H
Mon Feb 01 00:00:00 EST 2010
Generation of homogeneous PDX1(+) pancreatic progenitors from human ES cell-derived endoderm cells.
Journal of molecular cell biology
Cai J,Yu C,Liu Y,Chen S,Guo Y,Yong J,Lu W,Ding M,Deng H
Mon Feb 01 00:00:00 EST 2010
Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.
Nature
Lee G,Papapetrou EP,Kim H,Chambers SM,Tomishima MJ,Fasano CA,Ganat YM,Menon J,Shimizu F,Viale A,Tabar V,Sadelain M,Studer L
Thu Sep 17 00:00:00 EDT 2009
Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells.
Cell research
Zhang D,Jiang W,Liu M,Sui X,Yin X,Chen S,Shi Y,Deng H
Wed Apr 01 00:00:00 EDT 2009
Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells.
Cell research
Song Z,Cai J,Liu Y,Zhao D,Yong J,Duo S,Song X,Guo Y,Zhao Y,Qin H,Yin X,Wu C,Che J,Lu S,Ding M,Deng H
Sun Nov 01 00:00:00 EDT 2009
Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14.
Blood
Salogni L,Musso T,Bosisio D,Mirolo M,Jala VR,Haribabu B,Locati M,Sozzani S
Thu Jun 04 00:00:00 EDT 2009
INHBA overexpression promotes cell proliferation and may be epigenetically regulated in esophageal adenocarcinoma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Seder CW,Hartojo W,Lin L,Silvers AL,Wang Z,Thomas DG,Giordano TJ,Chen G,Chang AC,Orringer MB,Beer DG
120-14 was used in In vitro experiments to show that INHBA is overexpressed in EAC relative to dysplastic and BM tissue. INHBA overexpression may promote cell proliferation and may be affected by promoter demethylation and histone acetylation in EAC cell lines.
Wed Apr 01 00:00:00 EDT 2009
Insulin-secreting cells from human eyelid-derived stem cells alleviate type I diabetes in immunocompetent mice.
Stem cells (Dayton, Ohio)
Kang HM,Kim J,Park S,Kim J,Kim H,Kim KS,Lee EJ,Seo SI,Kang SG,Lee JE,Lim H
Sat Aug 01 00:00:00 EDT 2009
Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells.
Cell stem cell
Idelson M,Alper R,Obolensky A,Ben-Shushan E,Hemo I,Yachimovich-Cohen N,Khaner H,Smith Y,Wiser O,Gropp M,Cohen MA,Even-Ram S,Berman-Zaken Y,Matzrafi L,Rechavi G,Banin E,Reubinoff B
Fri Oct 02 00:00:00 EDT 2009
Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling.
Proceedings of the National Academy of Sciences of the United States of America
Hay DC,Fletcher J,Payne C,Terrace JD,Gallagher RC,Snoeys J,Black JR,Wojtacha D,Samuel K,Hannoun Z,Pryde A,Filippi C,Currie IS,Forbes SJ,Ross JA,Newsome PN,Iredale JP
Tue Aug 26 00:00:00 EDT 2008
Generation of insulin-secreting islet-like clusters from human skin fibroblasts.
The Journal of biological chemistry
Tateishi K,He J,Taranova O,Liang G,D'Alessio AC,Zhang Y
Fri Nov 14 00:00:00 EST 2008
Axon-bearing and axon-less horizontal cell subtypes are generated consecutively during chick retinal development from progenitors that are sensitive to follistatin.
BMC developmental biology
Edqvist PH,Lek M,Boije H,Lindbäck SM,Hallböök F
Fri Apr 25 00:00:00 EDT 2008
Regulation of apoptosis and differentiation by p53 in human embryonic stem cells.
The Journal of biological chemistry
Qin H,Yu T,Qing T,Liu Y,Zhao Y,Cai J,Li J,Song Z,Qu X,Zhou P,Wu J,Ding M,Deng H
Fri Feb 23 00:00:00 EST 2007
A method for the selection of human embryonic stem cell sublines with high replating efficiency after single-cell dissociation.
Stem cells (Dayton, Ohio)
Hasegawa K,Fujioka T,Nakamura Y,Nakatsuji N,Suemori H
Fri Dec 01 00:00:00 EST 2006
