Product References
Spatially controlled construction of assembloids using bioprinting.
Nature communications
Roth JG,Brunel LG,Huang MS,Liu Y,Cai B,Sinha S,Yang F,Pașca SP,Shin S,Heilshorn SC
AF-450-02 was used in Cell Culture to demonstrate the potential for the SPOT platform to construct assembloids which recapitulate key developmental processes and disease etiologies.
Wed Jul 19 00:00:00 EDT 2023
Intra-amniotic mesenchymal stem cell therapy improves the amniotic fluid microenvironment in rat spina bifida aperta fetuses.
Cell proliferation
Wei X,Ma W,Gu H,Liu D,Luo W,Cao S,Jia S,Huang T,He Y,Bai Y,Wang W,Yuan Z
AF-450-02 was used in In vivo experiments to examine whether the amniotic fluid microenvironment can be improved by intra-amniotic BMSC transplantation.
Wed Feb 01 00:00:00 EST 2023
The causal involvement of the BDNF-TrkB pathway in dentate gyrus in early-life stress-induced cognitive deficits in male mice.
Translational psychiatry
Sun YX,Su YA,Wang Q,Zheng JY,Zhang CC,Wang T,Liu X,Ma YN,Li XX,Zhang XQ,Xie XM,Wang XD,Li JT,Si TM
AF-450-02 was used in In vivo experiments to highlight BDNF-TrkB system as the molecular target of ELS-induced spatial memory deficits and provide translational evidence for the intervention at this system in the treatment of cognitive deficits in stress-related psychiatric disorders, such as major depressive disorder.
Wed May 24 00:00:00 EDT 2023
Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome.
International journal of molecular sciences
Campbell NB,Patel Y,Moore TL,Medalla M,Zeldich E
AF-450-02 was used in Cell Culture to show the efficacy of EVs in mitigating DS and AD-related cellular phenotypes and pathological depositions in human CS.
Thu Feb 09 00:00:00 EST 2023
VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway.
Cells
Zhang X,Zhou K,Tian K,Zhu Q,Liu W,Liu Z,An X,Tian C,Li Y,Lu F,Sun F,Zha D
AF-450-02 was used in Cell Culture to determine the expression and function of BNP and found that the vitamin D receptor (VDR) could upregulate the expression of BNP and enhance its function.
Wed Nov 23 00:00:00 EST 2022
Programmable RNA targeting with the single-protein CRISPR effector Cas7-11.
Nature
Özcan A,Krajeski R,Ioannidi E,Lee B,Gardner A,Makarova KS,Koonin EV,Abudayyeh OO,Gootenberg JS
Wed Sep 01 00:00:00 EDT 2021
Generation and validation of APOE knockout human iPSC-derived cerebral organoids.
STAR protocols
Martens YA,Xu S,Tait R,Li G,Zhao XC,Lu W,Liu CC,Kanekiyo T,Bu G,Zhao J
AF-450-02 was used in Cell Culture to describe a protocol for efficient knockout of apolipoprotein E in human induced pluripotent stem cells (iPSCs) using the CRISPR-Cas9 system.
Fri Jun 18 00:00:00 EDT 2021
Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Vázquez-Vélez GE,Gonzales KA,Revelli JP,Adamski CJ,Alavi Naini F,Bajić A,Craigen E,Richman R,Heman-Ackah SM,Wood MJA,Rousseaux MWC,Zoghbi HY
AF-450-02 was used in Cell Culture to provide evidence for a novel function for DCLK1 in the mature brain, and for its potential as a new therapeutic target for synucleinopathies.
Wed Jan 08 00:00:00 EST 2020
Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi.
Nature communications
Hong SP,Yang MJ,Cho H,Park I,Bae H,Choe K,Suh SH,Adams RH,Alitalo K,Lim D,Koh GY
Fri Aug 14 00:00:00 EDT 2020
Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson's disease models.
Cell death & disease
Zhuang XX,Wang SF,Tan Y,Song JX,Zhu Z,Wang ZY,Wu MY,Cai CZ,Huang ZJ,Tan JQ,Su HX,Li M,Lu JH
Tue Feb 18 00:00:00 EST 2020
Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling.
Cell death & disease
Ke M,Chong CM,Zeng H,Huang M,Huang Z,Zhang K,Cen X,Lu JH,Yao X,Qin D,Su H
Tue Feb 18 00:00:00 EST 2020
Inhibition of Apoptosis Reduces Diploidization of Haploid Mouse Embryonic Stem Cells during Differentiation.
Stem cell reports
Zhang W,Tian Y,Gao Q,Li X,Li Y,Zhang J,Yao C,Wang Y,Wang H,Zhao Y,Zhang Q,Li L,Yu Y,Fan Y,Shuai L
Tue Jul 14 00:00:00 EDT 2020
JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells.
Nature communications
Shan Y,Zhang Y,Zhao Y,Wang T,Zhang J,Yao J,Ma N,Liang Z,Huang W,Huang K,Zhang T,Su Z,Chen Q,Zhu Y,Wu C,Zhou T,Sun W,Wei Y,Zhang C,Li C,Su S,Liao B,Zhong M,Zhong X,Nie J,Pei D,Pan G
Mon Jan 20 00:00:00 EST 2020
Endothelin-1 Mediated Decrease in Mitochondrial Gene Expression and Bioenergetics Contribute to Neurodegeneration of Retinal Ganglion Cells.
Scientific reports
Chaphalkar RM,Stankowska DL,He S,Kodati B,Phillips N,Prah J,Yang S,Krishnamoorthy RR
Thu Feb 27 00:00:00 EST 2020
Cofilin dysregulation alters actin turnover in frataxin-deficient neurons.
Scientific reports
Muñoz-Lasso DC,Mollá B,Calap-Quintana P,García-Giménez JL,Pallardo FV,Palau F,Gonzalez-Cabo P
Mon Mar 23 00:00:00 EDT 2020
Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain.
Nature communications
Lorenzo LE,Godin AG,Ferrini F,Bachand K,Plasencia-Fernandez I,Labrecque S,Girard AA,Boudreau D,Kianicka I,Gagnon M,Doyon N,Ribeiro-da-Silva A,De Koninck Y
Thu Feb 13 00:00:00 EST 2020
CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual.
Communications biology
Yun Y,Hong SA,Kim KK,Baek D,Lee D,Londhe AM,Lee M,Yu J,McEachin ZT,Bassell GJ,Bowser R,Hales CM,Cho SR,Kim J,Pae AN,Cheong E,Kim S,Boulis NM,Bae S,Ha Y
Mon Jan 20 00:00:00 EST 2020
Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina.
Cell
Peng YR,Shekhar K,Yan W,Herrmann D,Sappington A,Bryman GS,van Zyl T,Do MTH,Regev A,Sanes JR
Thu Feb 21 00:00:00 EST 2019
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning.
Nature neuroscience
Sellgren CM,Gracias J,Watmuff B,Biag JD,Thanos JM,Whittredge PB,Fu T,Worringer K,Brown HE,Wang J,Kaykas A,Karmacharya R,Goold CP,Sheridan SD,Perlis RH
AF-450-02 was used in Cell Culture to demonstrate increased synapse elimination in patient-derived neural cultures and isolated synaptosomes.
Fri Mar 01 00:00:00 EST 2019
mTOR and autophagy pathways are dysregulated in murine and human models of Schaaf-Yang syndrome.
Scientific reports
Crutcher E,Pal R,Naini F,Zhang P,Laugsch M,Kim J,Bajic A,Schaaf CP
Mon Nov 04 00:00:00 EST 2019
Mitochondrial deficits in human iPSC-derived neurons from patients with 22q11.2 deletion syndrome and schizophrenia.
Translational psychiatry
Li J,Ryan SK,Deboer E,Cook K,Fitzgerald S,Lachman HM,Wallace DC,Goldberg EM,Anderson SA
Mon Nov 18 00:00:00 EST 2019
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Cell
Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM
Thu Jan 25 00:00:00 EST 2018
ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism.
Neuron
Rousseaux MWC,Tschumperlin T,Lu HC,Lackey EP,Bondar VV,Wan YW,Tan Q,Adamski CJ,Friedrich J,Twaroski K,Chen W,Tolar J,Henzler C,Sharma A,Bajić A,Lin T,Duvick L,Liu Z,Sillitoe RV,Zoghbi HY,Orr HT
Wed Mar 21 00:00:00 EDT 2018
Mesenchymal Stem Cells Protect Against Hypoxia-Ischemia Brain Damage by Enhancing Autophagy Through Brain Derived Neurotrophic Factor/Mammalin Target of Rapamycin Signaling Pathway.
Stem cells (Dayton, Ohio)
Zheng Z,Zhang L,Qu Y,Xiao G,Li S,Bao S,Lu QR,Mu D
Sun Jul 01 00:00:00 EDT 2018
Neural Progenitor-Like Cells Induced from Human Gingiva-Derived Mesenchymal Stem Cells Regulate Myelination of Schwann Cells in Rat Sciatic Nerve Regeneration.
Stem cells translational medicine
Zhang Q,Nguyen P,Xu Q,Park W,Lee S,Furuhashi A,Le AD
Wed Feb 01 00:00:00 EST 2017
Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling.
Neuron
Duan X,Qiao M,Bei F,Kim IJ,He Z,Sanes JR
Wed Mar 18 00:00:00 EDT 2015
TrkB/BDNF signalling patterns the sympathetic nervous system.
Nature communications
Kasemeier-Kulesa JC,Morrison JA,Lefcort F,Kulesa PM
Fri Sep 25 00:00:00 EDT 2015
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
Cell
Xue Y,Ouyang K,Huang J,Zhou Y,Ouyang H,Li H,Wang G,Wu Q,Wei C,Bi Y,Jiang L,Cai Z,Sun H,Zhang K,Zhang Y,Chen J,Fu XD
Thu Jan 17 00:00:00 EST 2013
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
Cell
Xue Y,Ouyang K,Huang J,Zhou Y,Ouyang H,Li H,Wang G,Wu Q,Wei C,Bi Y,Jiang L,Cai Z,Sun H,Zhang K,Zhang Y,Chen J,Fu XD
Thu Jan 17 00:00:00 EST 2013
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11.
Nature
Vilchez D,Boyer L,Morantte I,Lutz M,Merkwirth C,Joyce D,Spencer B,Page L,Masliah E,Berggren WT,Gage FH,Dillin A
Thu Sep 13 00:00:00 EDT 2012
Long-distance growth and connectivity of neural stem cells after severe spinal cord injury.
Cell
Lu P,Wang Y,Graham L,McHale K,Gao M,Wu D,Brock J,Blesch A,Rosenzweig ES,Havton LA,Zheng B,Conner JM,Marsala M,Tuszynski MH
Fri Sep 14 00:00:00 EDT 2012
BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus.
Proceedings of the National Academy of Sciences of the United States of America
Jeanneteau FD,Lambert WM,Ismaili N,Bath KG,Lee FS,Garabedian MJ,Chao MV
Tue Jan 24 00:00:00 EST 2012
Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc.
Proceedings of the National Academy of Sciences of the United States of America
Giorgetti A,Marchetto MC,Li M,Yu D,Fazzina R,Mu Y,Adamo A,Paramonov I,Cardoso JC,Monasterio MB,Bardy C,Cassiani-Ingoni R,Liu GH,Gage FH,Izpisua Belmonte JC
Tue Jul 31 00:00:00 EDT 2012
Serum Response Factor (SRF)-cofilin-actin signaling axis modulates mitochondrial dynamics.
Proceedings of the National Academy of Sciences of the United States of America
Beck H,Flynn K,Lindenberg KS,Schwarz H,Bradke F,Di Giovanni S,Knöll B
Tue Sep 18 00:00:00 EDT 2012
Increasing doublecortin expression promotes migration of human embryonic stem cell-derived neurons.
Stem cells (Dayton, Ohio)
Filipovic R,Santhosh Kumar S,Fiondella C,Loturco J
Sat Sep 01 00:00:00 EDT 2012
Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington's disease.
Experimental neurology
Sadan O,Shemesh N,Barzilay R,Dadon-Nahum M,Blumenfeld-Katzir T,Assaf Y,Yeshurun M,Djaldetti R,Cohen Y,Melamed E,Offen D
Sun Apr 01 00:00:00 EDT 2012
Pigment epithelium-derived factor released by Müller glial cells exerts neuroprotective effects on retinal ganglion cells.
Neurochemical research
Unterlauft JD,Eichler W,Kuhne K,Yang XM,Yafai Y,Wiedemann P,Reichenbach A,Claudepierre T
Sun Jul 01 00:00:00 EDT 2012
The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development.
PloS one
Di Lieto A,Rantamäki T,Vesa L,Yanpallewar S,Antila H,Lindholm J,Rios M,Tessarollo L,Castrén E
Mon Jul 23 00:00:00 EDT 2012
Differential involvement of brain-derived neurotrophic factor in reconsolidation and consolidation of conditioned taste aversion memory.
PloS one
Wang Y,Zhang TY,Xin J,Li T,Yu H,Li N,Chen ZY
Thu May 30 00:00:00 EDT 2013
miR-200c targets a NF-κB up-regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer.
PloS one
Howe EN,Cochrane DR,Cittelly DM,Richer JK
Thu May 30 00:00:00 EDT 2013
Plasticity of Scarpa's Ganglion Neurons as a Possible Basis for Functional Restoration within Vestibular Endorgans.
Frontiers in neurology
Travo C,Gaboyard-Niay S,Chabbert C
Tue Oct 02 00:00:00 EDT 2012
Plasticity of Scarpa's Ganglion Neurons as a Possible Basis for Functional Restoration within Vestibular Endorgans.
Frontiers in neurology
Travo C,Gaboyard-Niay S,Chabbert C
Tue Oct 02 00:00:00 EDT 2012
Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors.
PloS one
Kawamura K,Chen Y,Shu Y,Cheng Y,Qiao J,Behr B,Pera RA,Hsueh AJ
Tue May 07 00:00:00 EDT 2013
LIM kinase 1 (LIMK1) interacts with tropomyosin-related kinase B (TrkB) and Mediates brain-derived neurotrophic factor (BDNF)-induced axonal elongation.
The Journal of biological chemistry
Dong Q,Ji YS,Cai C,Chen ZY
Fri Dec 07 00:00:00 EST 2012
Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism.
PloS one
Killian RL,Flippin JD,Herrera CM,Almenar-Queralt A,Goldstein LS
Mon Jun 11 00:00:00 EDT 2012
3D multicolor super-resolution imaging offers improved accuracy in neuron tracing.
PloS one
Lakadamyali M,Babcock H,Bates M,Zhuang X,Lichtman J
Mon Jun 04 00:00:00 EDT 2012
Highly pure and expandable PSA-NCAM-positive neural precursors from human ESC and iPSC-derived neural rosettes.
PloS one
Kim DS,Lee DR,Kim HS,Yoo JE,Jung SJ,Lim BY,Jang J,Kang HC,You S,Hwang DY,Leem JW,Nam TS,Cho SR,Kim DW
Fri Apr 19 00:00:00 EDT 2013
Burst analysis tool for developing neuronal networks exhibiting highly varying action potential dynamics.
Frontiers in computational neuroscience
Kapucu FE,Tanskanen JM,Mikkonen JE,Ylä-Outinen L,Narkilahti S,Hyttinen JA
Thu Aug 23 00:00:00 EDT 2012
Adult human brain neural progenitor cells (NPCs) and fibroblast-like cells have similar properties in vitro but only NPCs differentiate into neurons.
PloS one
Park TI,Monzo H,Mee EW,Bergin PS,Teoh HH,Montgomery JM,Faull RL,Curtis MA,Dragunow M
Thu Oct 11 00:00:00 EDT 2012
A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma.
The Journal of biological chemistry
Hayashi H,Eguchi Y,Fukuchi-Nakaishi Y,Takeya M,Nakagata N,Tanaka K,Vance JE,Tanihara H
Fri Jul 20 00:00:00 EDT 2012
Inhibition of BDNF in multiple myeloma blocks osteoclastogenesis via down-regulated stroma-derived RANKL expression both in vitro and in vivo.
PloS one
Ai LS,Sun CY,Zhang L,Zhou SC,Chu ZB,Qin Y,Wang YD,Zeng W,Yan H,Guo T,Chen L,Yang D,Hu Y
Wed Mar 20 00:00:00 EDT 2013
Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons.
Cell
Qiang L,Fujita R,Yamashita T,Angulo S,Rhinn H,Rhee D,Doege C,Chau L,Aubry L,Vanti WB,Moreno H,Abeliovich A
Fri Aug 05 00:00:00 EDT 2011
Development of a method for the purification and culture of rodent astrocytes.
Neuron
Foo LC,Allen NJ,Bushong EA,Ventura PB,Chung WS,Zhou L,Cahoy JD,Daneman R,Zong H,Ellisman MH,Barres BA
Thu Sep 08 00:00:00 EDT 2011
Regulation of chemotropic guidance of nerve growth cones by microRNA.
Molecular brain
Han L,Wen Z,Lynn RC,Baudet ML,Holt CE,Sasaki Y,Bassell GJ,Zheng JQ
Thu Nov 03 00:00:00 EDT 2011
Biophysical characteristics reveal neural stem cell differentiation potential.
PloS one
Labeed FH,Lu J,Mulhall HJ,Marchenko SA,Hoettges KF,Estrada LC,Lee AP,Hughes MP,Flanagan LA
Thu Jan 26 00:00:00 EST 2012
Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model.
Molecular brain
Swanger SA,Yao X,Gross C,Bassell GJ
Fri Oct 07 00:00:00 EDT 2011
Efficient derivation of human neuronal progenitors and neurons from pluripotent human embryonic stem cells with small molecule induction.
Journal of visualized experiments : JoVE
Parsons XH,Teng YD,Parsons JF,Snyder EY,Smotrich DB,Moore DA
Fri Oct 28 00:00:00 EDT 2011
