Product References
Deterministic nuclear reprogramming of mammalian nuclei to a totipotency-like state by Amphibian meiotic oocytes for stem cell therapy in humans.
Biology open
Wen MH,Barbosa Triana H,Butler R,Hu HW,Dai YH,Lawrence N,Hong JJ,Garrett N,Jones-Green R,Rawlins EL,Dong Z,Koziol MJ,Gurdon JB
450-02 was used in Cell Culture to conclude that much of the reprogramming effect of eggs is already present in meiotic oocytes and does not require cell division or selection of dividing cells.
Fri Mar 01 00:00:00 EST 2024
The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor.
Frontiers in molecular neuroscience
Knorr DY,Rodriguez Polo I,Pies HS,Schwedhelm-Domeyer N,Pauls S,Behr R,Heinrich R
450-02 was used in Cell Culture to show that the human CRLF3 mediates neuroprotection upon activation with the natural Epo splice variant EV-3.
Sun May 14 00:00:00 EDT 2023
MiR34 contributes to spinal muscular atrophy and AAV9-mediated delivery of MiR34a ameliorates the motor deficits in SMA mice.
Molecular therapy. Nucleic acids
Chen TH,Chang SH,Wu YF,Yen YP,Hsu FY,Chen YC,Ming Y,Hsu HC,Su YC,Wong ST,Hung JH,Chiou SH,Jong YJ,Chen JA
450-02 was used in In vitro experiments to propose that MiR34 may serve as a biomarker of SMA since it is associated with the pathology and can help evaluate the therapeutic effects of nusinersen.
Tue Jun 13 00:00:00 EDT 2023
An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids.
Cells
Castellanos-Montiel MJ,Chaineau M,Franco-Flores AK,Haghi G,Carrillo-Valenzuela D,Reintsch WE,Chen CX,Durcan TM
450-02 was used in Cell Culture to develop an MN 3D model, and we optimized a workflow that can be applied to perform its morphological, gene expression, protein, and functional profiling over time.
Wed Feb 08 00:00:00 EST 2023
Asymmetric charge balanced waveforms direct retinal ganglion cell axon growth.
Scientific reports
Peng MG,Iseri E,Simonyan A,Lam P,Kim T,Medvidovic S,Paknahad J,Machnoor M,Lazzi G,Gokoffski KK
450-02 was used in Tissue/organ culture to demonstrate the relative influence of pulse amplitude and pulse width on the overall effectiveness of stimulation.
Mon Aug 14 00:00:00 EDT 2023
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.
Molecular neurodegeneration
Hasan S,Fernandopulle MS,Humble SW,Frankenfield AM,Li H,Prestil R,Johnson KR,Ryan BJ,Wade-Martins R,Ward ME,Hao L
450-02 was used in Cell Culture to suggest PGRN as a critical regulator of lysosomal pH and degradative capacity, which influences global proteostasis in neurons.
Thu Nov 16 00:00:00 EST 2023
Axin2 coupled excessive Wnt-glycolysis signaling mediates social defect in autism spectrum disorders.
EMBO molecular medicine
Wang M,Xian P,Zheng W,Li Z,Chen A,Xiao H,Xu C,Wang F,Mao H,Meng H,Zhao Y,Luo C,Wang Y,Wu S
450-02 was used in In vitro experiments to reveal excessive neuronal Wnt-glycolysis signaling as an important underlying mechanism for ASD synaptic deficiency, indicating Axin2 as a potential therapeutic target for social dysfunction.
Wed Jun 07 00:00:00 EDT 2023
Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression.
Nature protocols
Liu Y,Wang J,Südhof TC,Wernig M
450-02 was used in Cell Culture to provide a detailed approach for the efficient and reproducible generation of functional iN cells from mouse ESC cultures by the genetically induced expression of neurogenin-2.
Sun Oct 01 00:00:00 EDT 2023
METTL3-Dependent N6-Methyladenosine Modification Programs Human Neural Progenitor Cell Proliferation.
International journal of molecular sciences
Zhao Y,Li J,Lian Y,Zhou Q,Wu Y,Kang J
450-02 was used in Cell Culture to reveal a novel functional target (SLIT2) for METTL3 in hNPCs and contribute to a better understanding of m6A-dependent mechanisms in hNPC proliferation.
Tue Oct 24 00:00:00 EDT 2023
Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction.
Communications biology
Breitmeyer R,Vogel S,Heider J,Hartmann SM,Wüst R,Keller AL,Binner A,Fitzgerald JC,Fallgatter AJ,Volkmer H
450-02 was used in In vitro experiments to present a co-culture model of neurons and microglia, both of human origin, to show increased susceptibility of neurons to microglia-like cells derived from SCZ patients.
Sat Apr 29 00:00:00 EDT 2023
In vitro characterization on the role of APOE polymorphism in human hippocampal neurogenesis.
Hippocampus
Lee H,Price J,Srivastava DP,Thuret S
450-02 was used in Cell Culture to find that APOE itself was more highly expressed in ε4 at the stem cell stage, while the divergence of differential gene expression phenotype between ε4 and ε3 became prominent at the neuronal stage of differentiation.
Sat Apr 01 00:00:00 EDT 2023
Convergent coexpression of autism-associated genes suggests some novel risk genes may not be detectable in large-scale genetic studies.
Cell genomics
Liao C,Moyses-Oliveira M,De Esch CEF,Bhavsar R,Nuttle X,Li A,Yu A,Burt ND,Erdin S,Fu JM,Wang M,Morley T,Han L,Dion PA,Rouleau GA,Zhang B,Brennand KJ,Talkowski ME,Ruderfer DM
450-02 was used in Cell Culture to indicate that convergent coexpression can identify potentially novel genes that are unlikely to be discovered by sequencing studies.
Wed Apr 12 00:00:00 EDT 2023
Transcription Factor-Mediated Differentiation of Motor Neurons from Human Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.)
Wu J,Tang Y
450-02 was used in Cell Culture to describe a method of generating functional MNs via lentiviral delivery of transcription factors, based on the preservable NPC platform derived from hPSCs.
Thu Dec 15 00:00:00 EST 2022
An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming.
Science advances
Weng M,Hu H,Graus MS,Tan DS,Gao Y,Ren S,Ho DHH,Langer J,Holzner M,Huang Y,Ling GS,Lai CSW,Francois M,Jauch R
450-02 was used in In vitro experiments to report iNSC reprogramming from embryonic and aged mouse fibroblasts as well as from human blood using an engineered Sox17 (eSox17FNV).
Fri Aug 25 00:00:00 EDT 2023
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells.
Nature biotechnology
Tao Y,Li X,Dong Q,Kong L,Petersen AJ,Yan Y,Xu K,Zima S,Li Y,Schmidt DK,Ayala M,Mathivanan S,Sousa AMM,Chang Q,Zhang SC
450-02 was used in Cell Culture to develop a method to generate 40-60% human LC-NE neurons from human pluripotent stem cells.
Thu Nov 16 00:00:00 EST 2023
Generation and characterization of NGLY1 patient-derived midbrain organoids.
Frontiers in cell and developmental biology
Abbott J,Tambe M,Pavlinov I,Farkhondeh A,Nguyen HN,Xu M,Pradhan M,York T,Might M,Baumgärtel K,Rodems S,Zheng W
450-02 was used in Cell Culture to provide a relevant NGLY1 disease model to investigate disease mechanisms and evaluate therapeutics for treatments of NGLY1 deficiency.
Tue Mar 07 00:00:00 EST 2023
Differential response of C9orf72 transcripts following neuronal depolarization.
iScience
Ghaffari LT,Trotti D,Haeusler AR
450-02 was used in Cell Culture to reveal the impact of depolarization on C9orf72 transcripts, and how this response diverges in C9-NRE-carriers, which may have important implications in the underlying unique clinical associations of C9-NRE transcripts and disease pathogenesis.
Fri Jun 16 00:00:00 EDT 2023
Higher throughput workflow with sensitive, reliable and automatic quantification of myelination in vitro suitable for drug screening.
Scientific reports
Seiler S,Wälti CM,de Barros V,Barbash S,Foo LC
450-02 was used in Cell Culture to develop a method allowing systematic and reliable testing of remyelinating compound efficacy.
Sat Feb 18 00:00:00 EST 2023
Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons.
Cell genomics
Zhang S,Zhang H,Forrest MP,Zhou Y,Sun X,Bagchi VA,Kozlova A,Santos MD,Piguel NH,Dionisio LE,Sanders AR,Pang ZP,He X,Penzes P,Duan J
450-02 was used in Cell Culture to reveal that multiple genes at a single GWAS risk locus mediate a compound effect on neural function, providing a mechanistic link between a non-coding risk variant and disease-related cellular phenotypes.
Wed Sep 13 00:00:00 EDT 2023
Glioma synapses recruit mechanisms of adaptive plasticity.
Nature
Taylor KR,Barron T,Hui A,Spitzer A,Yalçin B,Ivec AE,Geraghty AC,Hartmann GG,Arzt M,Gillespie SM,Kim YS,Maleki Jahan S,Zhang H,Shamardani K,Su M,Ni L,Du PP,Woo PJ,Silva-Torres A,Venkatesh HS,Mancusi R,Ponnuswami A,Mulinyawe S,Keough MB,Chau I,Aziz-Bose R,Tirosh I,Suvà ML,Monje M
450-02 was used in Sample Preparation to indicate that brain-derived neurotrophic factor1-3-TrkB signalling promotes malignant synaptic plasticity and augments tumour progression.
Wed Nov 01 00:00:00 EDT 2023
C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress.
iScience
Cicardi ME,Hallgren JH,Mawrie D,Krishnamurthy K,Markandaiah SS,Nelson AT,Kankate V,Anderson EN,Pasinelli P,Pandey UB,Eischen CM,Trotti D
450-02 was used in Cell Culture to find evidence for the induction of programmed cell death via caspase-3 activation.
Fri Sep 15 00:00:00 EDT 2023
Real-time thiol detection in iPSC-derived neuron cultures using SemKur-IM, a novel fluorescent dithio probe.
SLAS discovery : advancing life sciences R & D
Alvarez R,Kurfis J,Hendrickson M,Sem DS
450-02 was used in Cell Culture to demonstrate the utility of SemKur-IM in the detection of thiol levels in live cells in response to chemical exposures, such as from drugs that return the cell to a healthier reduced state.
Mon Nov 20 00:00:00 EST 2023
Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment.
Nature
Meng X,Yao D,Imaizumi K,Chen X,Kelley KW,Reis N,Thete MV,Arjun McKinney A,Kulkarni S,Panagiotakos G,Bassik MC,Pașca SP
450-02 was used in In vitro experiments to highlight the power of this CRISPR-assembloid platform to systematically map NDD genes onto human development and reveal disease mechanisms.
Sun Oct 01 00:00:00 EDT 2023
Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons.
Nature communications
Halawani D,Wang Y,Ramakrishnan A,Estill M,He X,Shen L,Friedel RH,Zou H
450-02 was used in Cell Culture to demonstrate that targeting Bmal1 enhances axon regeneration.
Thu Aug 24 00:00:00 EDT 2023
Protocol Optimization for Direct Reprogramming of Primary Human Fibroblast into Induced Striatal Neurons.
International journal of molecular sciences
Kraskovskaya N,Bolshakova A,Khotin M,Bezprozvanny I,Mikhailova N
450-02 was used in Cell Culture to demonstrate that iSNs are functionally active and able to form synaptic connections in co-cultures with mouse cortical neurons.
Wed Apr 05 00:00:00 EDT 2023
Brain-derived neurotrophic factor (BDNF) induces antagonistic action to Nogo signaling by the upregulation of lateral olfactory tract usher substance (LOTUS) expression.
Journal of neurochemistry
Matsubayashi J,Kawaguchi Y,Kawakami Y,Takei K
450-02 was used in In vitro experiments to suggest that BDNF may acts as a positive regulator of LOTUS expression through the TrkB signaling, thereby inducing an antagonistic action for NgR1 function by up-regulating LOTUS expression.
Sun Jan 01 00:00:00 EST 2023
Accelerated differentiation of human induced pluripotent stem cells into regionally specific dorsal and ventral spinal neural progenitor cells for application in spinal cord therapeutics.
Frontiers in neuroscience
Huntemer-Silveira A,Malone D,Frie A,Walsh P,Parr AM
450-02 was used in In vitro experiments to describe here the production of a diverse population of both ventral spinal and dorsal horn progenitor cells.
Sat Feb 10 00:00:00 EST 2024
Glycolysis mediates neuron specific histone acetylation in valproic acid-induced human excitatory neuron differentiation.
Frontiers in molecular neuroscience
Chen A,Wang M,Xu C,Zhao Y,Xian P,Li Y,Zheng W,Yi X,Wu S,Wang Y
450-02 was used in Cell Culture to demonstrate that VPA biased excitatory neuron differentiation by glycolysis-mediated histone acetylation of neuron specific transcription factors.
Tue Apr 25 00:00:00 EDT 2023
Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.
JCI insight
Sleigh JN,Villarroel-Campos D,Surana S,Wickenden T,Tong Y,Simkin RL,Vargas JNS,Rhymes ER,Tosolini AP,West SJ,Zhang Q,Yang XL,Schiavo G
450-02 was used in In vivo experiments to suggest that selectively targeting muscles with BDNF-boosting therapies could represent a viable therapeutic strategy for CMT2D.
Mon May 08 00:00:00 EDT 2023
Protocol for 3D Bioprinting Mesenchymal Stem Cell-derived Neural Tissues Using a Fibrin-based Bioink.
Bio-protocol
Perez MR,Masri NZ,Walters-Shumka J,Kahale S,Willerth SM
450-02 was used in Cell Culture to describe the process of preparing Axolotl Biosciences TissuePrint - High Viscosity (HV) and Low Viscosity (LV) bioink, the incorporation of MSCs to the bioink, setting up the BIO X and the Aspect RX1 bioprinters, and necessary computer-aided design (CAD) files.
Fri May 05 00:00:00 EDT 2023
Single-cell RNA sequencing reveals the developmental program underlying proximal-distal patterning of the human lung at the embryonic stage.
Cell research
Cao S,Feng H,Yi H,Pan M,Lin L,Zhang YS,Feng Z,Liang W,Cai B,Li Q,Xiong Z,Shen Q,Ke M,Zhao X,Chen H,He Q,Min M,Cai Q,Liu H,Wang J,Pei D,Chen J,Ma Y
450-02 was used in In vitro experiments to elucidate the cell fate bifurcation and maturation of airway and vascular smooth muscle progenitor cells at the early stage of lung development.
Thu Jun 01 00:00:00 EDT 2023
Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2.
iScience
Flamier A,Bisht P,Richards A,Tomasello DL,Jaenisch R
450-02 was used in Cell Culture to indicate that sensory neurons can be infected by the original WA1/2020 strain of SARS-CoV-2 as well as the delta and omicron variants, yet infectability differs between the original strain and the variants.
Fri Sep 15 00:00:00 EDT 2023
Three-dimensional co-culture platform of human induced pluripotent stem cell-derived oligodendrocyte lineage cells and neurons for studying myelination.
STAR protocols
von der Bey M,De Cicco S,Zach S,Hengerer B,Ercan-Herbst E
450-02 was used in In vitro experiments to describe steps to differentiate hiPSCs into cortical neurons and oligodendrocyte lineage cells on 3D nanofibers.
Fri Mar 17 00:00:00 EDT 2023
The evolutionary history of the polyQ tract in huntingtin sheds light on its functional pro-neural activities.
Cell death and differentiation
Iennaco R,Formenti G,Trovesi C,Rossi RL,Zuccato C,Lischetti T,Bocchi VD,Scolz A,Martínez-Labarga C,Rickards O,Pacifico M,Crottini A,Møller AP,Chen RZ,Vogt TF,Pavesi G,Horner DS,Saino N,Cattaneo E
450-02 was used in In vitro experiments to investigate the function and evolution of the physiological CAG tract in the HTT gene. We show that the poly-glutamine (polyQ) tract encoded by CAGs in the huntingtin protein (HTT) is under purifying selection and subjected to stronger selective pressures than CAG-encoded polyQ tracts in other proteins.
Tue Feb 01 00:00:00 EST 2022
Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment.
Movement disorders : official journal of the Movement Disorder Society
Jarazo J,Barmpa K,Modamio J,Saraiva C,Sabaté-Soler S,Rosety I,Griesbeck A,Skwirblies F,Zaffaroni G,Smits LM,Su J,Arias-Fuenzalida J,Walter J,Gomez-Giro G,Monzel AS,Qing X,Vitali A,Cruciani G,Boussaad I,Brunelli F,Jäger C,Rakovic A,Li W,Yuan L,Berger E,Arena G,Bolognin S,Schmidt R,Schröder C,Antony PMA,Klein C,Krüger R,Seibler P,Schwamborn JC
Sat Jan 01 00:00:00 EST 2022
Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.
Cellular and molecular life sciences : CMLS
Solomon S,Sampathkumar NK,Carre I,Mondal M,Chennell G,Vernon AC,Ruepp MD,Mitchell JC
450-02 was used in Sample Preparation to investigate P522R in Alzheimer’s disease.
Wed Jul 27 00:00:00 EDT 2022
Human Spinal Organoid-on-a-Chip to Model Nociceptive Circuitry for Pain Therapeutics Discovery.
Analytical chemistry
Ao Z,Cai H,Wu Z,Krzesniak J,Tian C,Lai YY,Mackie K,Guo F
Tue Jan 18 00:00:00 EST 2022
Spinal dI4 Interneuron Differentiation From Human Pluripotent Stem Cells.
Frontiers in molecular neuroscience
Xu J,Huang LJ,Fang Z,Luo HM,Chen YQ,Li YJ,Gong CZ,Chen H
450-02 was used in Cell Culture to investigate spinal interneuron targeting in spinal cord injury treatment.
Fri Apr 29 00:00:00 EDT 2022
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.
Cell stem cell
Capano LS,Sato C,Ficulle E,Yu A,Horie K,Kwon JS,Burbach KF,Barthélemy NR,Fox SG,Karch CM,Bateman RJ,Houlden H,Morimoto RI,Holtzman DM,Duff KE,Yoo AS
450-02 was used in Cell Culture to demonstrate the utility of miRNA-induced neuronal reprogramming to recapitulate endogenous tau regulation comparable with the adult brain in health and disease.
Thu Jun 02 00:00:00 EDT 2022
The mitochondrial RNA granule modulates manganese-dependent cell toxicity.
Molecular biology of the cell
Werner E,Gokhale A,Ackert M,Xu C,Wen Z,Roberts AM,Roberts BR,Vrailas-Mortimer A,Crocker A,Faundez V
450-02 was used in Cell Culture to conclude that impairment of the mitochondrial RNA granule function is a protective mechanism for acute manganese toxicity.
Sat Oct 01 00:00:00 EDT 2022
A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer.
Cell reports methods
Shimada H,Sato Y,Sasaki T,Shimozawa A,Imaizumi K,Shindo T,Miyao S,Kiyama K,Kondo T,Shibata S,Ishii S,Kuromitsu J,Aoyagi H,Ito D,Okano H
450-02 was used in Tissue/organ culture to show that this model can be used as a platform for investigating pathogenetic mechanisms and evaluation of target molecules for drug discovery for tauopathy.
Mon Sep 19 00:00:00 EDT 2022
DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family.
Brain : a journal of neurology
Cheng F,Zheng W,Barbuti PA,Bonsi P,Liu C,Casadei N,Ponterio G,Meringolo M,Admard J,Dording CM,Yu-Taeger L,Nguyen HP,Grundmann-Hauser K,Ott T,Houlden H,Pisani A,Krüger R,Riess O
450-02 was used in Cell Culture to characterize the function of THAP1 and contributes to the understanding of the pathogenesis of primary dystonia in humans and rats.
Mon Nov 21 00:00:00 EST 2022
Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity.
Neuron
Martins LF,Brambilla I,Motta A,de Pretis S,Bhat GP,Badaloni A,Malpighi C,Amin ND,Imai F,Almeida RD,Yoshida Y,Pfaff SL,Bonanomi D
450-02 was used in Cell Culture to show that Plexin-D1 receptor is required in endothelial cells for development of neuromuscular connectivity.
Wed Dec 21 00:00:00 EST 2022
Large-Scale Production of Wholly Cellular Bioinks via the Optimization of Human Induced Pluripotent Stem Cell Aggregate Culture in Automated Bioreactors.
Advanced healthcare materials
Ho DLL,Lee S,Du J,Weiss JD,Tam T,Sinha S,Klinger D,Devine S,Hamfeldt A,Leng HT,Herrmann JE,He M,Fradkin LG,Tan TK,Standish D,Tomasello P,Traul D,Dianat N,Ladi R,Vicard Q,Katikireddy K,Skylar-Scott MA
450-02 was used in In vitro experiments to demonstrate an optimized suspension culture-to-3D bioprinting pipeline that enables a sustainable approach to billion cell-scale organ engineering.
Thu Dec 01 00:00:00 EST 2022
Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo.
Science advances
Cheng F,Zheng W,Liu C,Barbuti PA,Yu-Taeger L,Casadei N,Huebener-Schmid J,Admard J,Boldt K,Junger K,Ueffing M,Houlden H,Sharma M,Kruger R,Grundmann-Hauser K,Ott T,Riess O
450-02 was used in Cell Culture to identify that the DYT6 gene product THAP1 (THAP domain-containing apoptosis-associated protein 1) and its interaction partner CTCF (CCCTC-binding factor) act as transcription regulators of SNCA.
Fri Nov 25 00:00:00 EST 2022
Anatomical differences in nociceptor neurons sensitivity.
Bioelectronic medicine
Crosson T,Talbot S
450-02 was used in Cell Culture to study whether Jugular Nodose Complex (JNC) and Dorsal Root Ganglia (DRG) neurons are phenotypically and transcriptomically different.
Wed Apr 06 00:00:00 EDT 2022
The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.
eLife
Niu F,Han P,Zhang J,She Y,Yang L,Yu J,Zhuang M,Tang K,Shi Y,Yang B,Liu C,Peng B,Ji SJ
450-02 was used in Cell Culture to show that the N6-methyladenosine (m6A) reader YTHDF2 is highly expressed in mouse retinal ganglion cells.
Fri Feb 18 00:00:00 EST 2022
16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis.
iScience
Tomasello DL,Kim JL,Khodour Y,McCammon JM,Mitalipova M,Jaenisch R,Futerman AH,Sive H
450-02 was used in Cell Culture to examine the function of the FAM57B gene to further assess the predicted connection with 16p11.2 deletion syndrome.
Fri Jan 21 00:00:00 EST 2022
A transgenic mouse embryonic stem cell line for puromycin selection of V0V interneurons from heterogenous induced cultures.
Stem cell research & therapy
Pardieck J,Harb M,Sakiyama-Elbert SE
450-02 was used in Cell Culture to generate a transgenic mESC line to enrich V0V INs from induced cultures to allow for a scalable, enriched population for future in vitro and in vivo studies.
Mon Mar 28 00:00:00 EDT 2022
Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis.
Neuron
Zhang S,Cooper-Knock J,Weimer AK,Shi M,Moll T,Marshall JNG,Harvey C,Nezhad HG,Franklin J,Souza CDS,Ning K,Wang C,Li J,Dilliott AA,Farhan S,Elhaik E,Pasniceanu I,Livesey MR,Eitan C,Hornstein E,Kenna KP,Veldink JH,Ferraiuolo L,Shaw PJ,Snyder MP
450-02 was used in Cell Culture to develop a machine learning approach called RefMap, which integrates functional genomics with GWAS summary statistics for gene discovery.
Wed Mar 16 00:00:00 EDT 2022
Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17.
Nature
Iram T,Kern F,Kaur A,Myneni S,Morningstar AR,Shin H,Garcia MA,Yerra L,Palovics R,Yang AC,Hahn O,Lu N,Shuken SR,Haney MS,Lehallier B,Iyer M,Luo J,Zetterberg H,Keller A,Zuchero JB,Wyss-Coray T
450-02 was used in Cell Culture to demonstrate the rejuvenating power of young CSF and identify Fgf17 as a key target to restore oligodendrocyte function in the ageing brain.
Sun May 01 00:00:00 EDT 2022
Innate frequency-discrimination hyperacuity in Williams-Beuren syndrome mice.
Cell
Davenport CM,Teubner BJW,Han SB,Patton MH,Eom TY,Garic D,Lansdell BJ,Shirinifard A,Chang TC,Klein J,Pruett-Miller SM,Blundon JA,Zakharenko SS
450-02 was used in Cell Culture to report that the mouse models of Williams-Beuren syndrome have innately enhanced frequency-discrimination acuity and improved frequency coding in the auditory cortex (ACx).
Thu Oct 13 00:00:00 EDT 2022
S1-END-seq reveals DNA secondary structures in human cells.
Molecular cell
Matos-Rodrigues G,van Wietmarschen N,Wu W,Tripathi V,Koussa NC,Pavani R,Nathan WJ,Callen E,Belinky F,Mohammed A,Napierala M,Usdin K,Ansari AZ,Mirkin SM,Nussenzweig A
450-02 was used in Cell Culture to identify dynamic DNA secondary structures in vivo that contribute to elevated genome instability.
Thu Oct 06 00:00:00 EDT 2022
Spotting-based differentiation of functional dopaminergic progenitors from human pluripotent stem cells.
Nature protocols
Kim J,Jeon J,Song B,Lee N,Ko S,Cha Y,Leblanc P,Seo H,Kim KS
450-02 was used in Cell Culture to present a protocol detailing how to grow hPSCs such as human induced pluripotent and embryonic stem cells in a physically confined area ('spot') and efficiently differentiate them into a highly enriched population of healthy and functional midbrain dopamine progenitors (mDAPs) and midbrain dopamine neurons (mDANs).
Tue Mar 01 00:00:00 EST 2022
PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson's disease.
Cell
Park H,Kam TI,Peng H,Chou SC,Mehrabani-Tabari AA,Song JJ,Yin X,Karuppagounder SS,Umanah GK,Rao AVS,Choi Y,Aggarwal A,Chang S,Kim H,Byun J,Liu JO,Dawson TM,Dawson VL
450-02 was used in Cell Culture to show that neurodegeneration induced by pathologic α-synuclein (α-syn) occurs via PAAN/MIF nuclease activity.
Thu May 26 00:00:00 EDT 2022
Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis.
Science advances
Murugan NJ,Vigran HJ,Miller KA,Golding A,Pham QL,Sperry MM,Rasmussen-Ivey C,Kane AW,Kaplan DL,Levin M
450-02 was used in Cell Culture to demonstrate the successful kickstarting" of endogenous regenerative pathways in a vertebrate model."
Fri Jan 28 00:00:00 EST 2022
Routine culture and study of adult human brain cells from neurosurgical specimens.
Nature protocols
Park TI,Smyth LCD,Aalderink M,Woolf ZR,Rustenhoven J,Lee K,Jansson D,Smith A,Feng S,Correia J,Heppner P,Schweder P,Mee E,Dragunow M
450-02 was used in Cell Culture to present a protocol to enable the investigation of human brain cells and facilitate translation of neuroscience research to the clinic.
Tue Feb 01 00:00:00 EST 2022
Hippocampal parvalbumin interneurons play a critical role in memory development.
Cell reports
Miranda JM,Cruz E,Bessières B,Alberini CM
450-02 was used in In vitro experiments to show that episodic infantile learning significantly increases the levels of parvalbumin in the dHPC 48 h after training.
Tue Nov 15 00:00:00 EST 2022
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.
Cell stem cell
Jin M,Xu R,Wang L,Alam MM,Ma Z,Zhu S,Martini AC,Jadali A,Bernabucci M,Xie P,Kwan KY,Pang ZP,Head E,Liu Y,Hart RP,Jiang P
450-02 was used in Cell Culture to provide in vivo evidence that human microglia respond to pathological tau by exhibiting dystrophic phenotypes.
Thu Jul 07 00:00:00 EDT 2022
Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics.
Journal of visualized experiments : JoVE
Frankenfield A,Ni J,Hao L
450-02 was used in Cell Culture to demonstrate a detailed protocol for endogenous (knock-in) lysosome proximity labeling proteomic method in human induced pluripotent stem cell (hiPSC)-derived neurons.
Thu Jun 23 00:00:00 EDT 2022
Special Focus on the Cellular Anti-Inflammatory Effects of Several Micro-Immunotherapy Formulations: Considerations Regarding Intestinal-, Immune-Axis-Related- and Neuronal-Inflammation Contexts.
Journal of inflammation research
Jacques C,Floris I
450-02 was used in Cell Culture to reveal that u-MIM-1 and u-MIM-2 both induced a slight decrease in the levels of IL-1β and TNF-α transcripts.
Thu Dec 22 00:00:00 EST 2022
Alzheimer's disease like neuropathology in Down syndrome cortical organoids.
Frontiers in cellular neuroscience
Zhao HH,Haddad GG
450-02 was used in Cell Culture to use induced pluripotent stem cell (iPSC) and iPSC-derived 3D cortical organoids to model Alzheimer's disease in Down syndrome and explore the earliest cellular and molecular changes during DS fetal brain development.
Tue Jan 03 00:00:00 EST 2023
In vitro-derived medium spiny neurons recapitulate human striatal development and complexity at single-cell resolution.
Cell reports methods
Conforti P,Bocchi VD,Campus I,Scaramuzza L,Galimberti M,Lischetti T,Talpo F,Pedrazzoli M,Murgia A,Ferrari I,Cordiglieri C,Fasciani A,Arenas E,Felsenfeld D,Biella G,Besusso D,Cattaneo E
450-02 was used in Cell Culture to develop an efficient method to generate D1 and D2-medium spiny neurons (MSNs) from hESC, which eventually could facilitate cell-replacement therapies for Huntington’s disease (HD).
Mon Dec 19 00:00:00 EST 2022
Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
He ZQ,Li YH,Feng GH,Yuan XW,Lu ZB,Dai M,Hu YP,Zhang Y,Zhou Q,Li W
450-02 was used in Cell Culture to report a robust method to convert fibroblasts to neurons through targeting the cytoskeleton followed by exposure to lineage-specification surroundings.
Sun May 01 00:00:00 EDT 2022
CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes.
Nature communications
Lam M,Takeo K,Almeida RG,Cooper MH,Wu K,Iyer M,Kantarci H,Zuchero JB
450-02 was used in Cell Culture to study how CNS myelin membrane addition requires exocytosis mediated by the vesicular SNARE proteins VAMP2/3.
Fri Sep 23 00:00:00 EDT 2022
CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes.
Nature communications
Lam M,Takeo K,Almeida RG,Cooper MH,Wu K,Iyer M,Kantarci H,Zuchero JB
450-02 was used in Cell Culture to study how CNS myelin membrane addition requires exocytosis mediated by the vesicular SNARE proteins VAMP2/3.
Fri Sep 23 00:00:00 EDT 2022
Foxa2 and Pet1 Direct and Indirect Synergy Drive Serotonergic Neuronal Differentiation.
Frontiers in neuroscience
Aydin B,Sierk M,Moreno-Estelles M,Tejavibulya L,Kumar N,Flames N,Mahony S,Mazzoni EO
450-02 was used in In vitro experiments to highlight the challenges in formulating generalizable rules for describing the behavior of TF combinations that program distinct neuronal subtypes.
Tue Aug 30 00:00:00 EDT 2022
Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.
Neuron
Goldsmith J,Ordureau A,Harper JW,Holzbaur ELF
450-02 was used in Cell Culture to propose that localized Drp1-dependent fission of nucleoid-enriched fragments in proximity to the sites of autophagosome biogenesis enhances their capture.
Wed Mar 16 00:00:00 EDT 2022
Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies.
Frontiers in pharmacology
Goldsteen PA,Sabogal Guaqueta AM,Mulder PPMFA,Bos IST,Eggens M,Van der Koog L,Soeiro JT,Halayko AJ,Mathwig K,Kistemaker LEM,Verpoorte EMJ,Dolga AM,Gosens R
450-02 was used in Cell Culture to develop a microfluidic chip, to represent a human in vitro platform, to model neuro-effector interactions in the airways that may be used for mechanistic studies into neuroplasticity in asthma and other lung diseases.
Fri Nov 18 00:00:00 EST 2022
P97/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration.
Brain communications
Wang F,Li S,Wang TY,Lopez GA,Antoshechkin I,Chou TF
450-02 was used in Cell Culture to find that two p97 inhibitors, CB-5083 and NMS-873, restore some dysregulated protein levels.
Tue Aug 30 00:00:00 EDT 2022
Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation.
Nature genetics
Kaluscha S,Domcke S,Wirbelauer C,Stadler MB,Durdu S,Burger L,Schübeler D
450-02 was used in Cell Culture to reveal methylation-sensitive TFs in vivo and argues that direct inhibition, rather than indirect repression by the tested MBD proteins, is the prevailing mechanism of methylation-mediated repression at regulatory regions and repeats.
Thu Dec 01 00:00:00 EST 2022
Veteran-derived cerebral organoids display multifaceted pathological defects in studies on Gulf War Illness.
Frontiers in cellular neuroscience
Yates PL,Case K,Sun X,Sullivan K,Baas PW,Qiang L
450-02 was used in Cell Culture to suggest that veteran-derived human cerebral organoids not only can be used as an innovative human model to uncover the cellular responses to GW toxicants but can also serve as a platform for developing personalized medicine approaches for the veterans.
Wed Jan 11 00:00:00 EST 2023
Human Endogenous Retrovirus K Envelope in Spinal Fluid of Amyotrophic Lateral Sclerosis Is Toxic.
Annals of neurology
Steiner JP,Bachani M,Malik N,DeMarino C,Li W,Sampson K,Lee MH,Kowalak J,Bhaskar M,Doucet-O'Hare T,Garcia-Montojo M,Cowen M,Smith B,Reoma LB,Medina J,Brunel J,Pierquin J,Charvet B,Perron H,Nath A
450-02 was used in Cell Culture to characterize the neurotoxic properties of HML-2 Env.Env neurotoxicity was detected in ALS cerebrospinal fluid and confirmed using recombinant Env protein in a cell-based assay and a mouse model.
Sat Oct 01 00:00:00 EDT 2022
ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function.
Cell reports
Baron DM,Fenton AR,Saez-Atienzar S,Giampetruzzi A,Sreeram A,Keagle PJ,Doocy VR,Smith NJ,Danielson EW,Andresano M,McCormack MC,Garcia J,Bercier V,Van Den Bosch L,Brent JR,Fallini C,Traynor BJ,Holzbaur ELF,Landers JE
450-02 was used in Cell Culture to support the hypothesis that causative ALS mutations result in a toxic gain of function in the intracellular motor KIF5A that disrupts intracellular trafficking and neuronal homeostasis.
Tue Apr 05 00:00:00 EDT 2022
Neurotoxic reactive astrocytes induce cell death via saturated lipids.
Nature
Guttenplan KA,Weigel MK,Prakash P,Wijewardhane PR,Hasel P,Rufen-Blanchette U,Münch AE,Blum JA,Fine J,Neal MC,Bruce KD,Gitler AD,Chopra G,Liddelow SA,Barres BA
Mon Nov 01 00:00:00 EDT 2021
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.
Cell
Nuñez JK,Chen J,Pommier GC,Cogan JZ,Replogle JM,Adriaens C,Ramadoss GN,Shi Q,Hung KL,Samelson AJ,Pogson AN,Kim JYS,Chung A,Leonetti MD,Chang HY,Kampmann M,Bernstein BE,Hovestadt V,Gilbert LA,Weissman JS
Thu Apr 29 00:00:00 EDT 2021
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Cell
Bowles KR,Silva MC,Whitney K,Bertucci T,Berlind JE,Lai JD,Garza JC,Boles NC,Mahali S,Strang KH,Marsh JA,Chen C,Pugh DA,Liu Y,Gordon RE,Goderie SK,Chowdhury R,Lotz S,Lane K,Crary JF,Haggarty SJ,Karch CM,Ichida JK,Goate AM,Temple S
Thu Aug 19 00:00:00 EDT 2021
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.
Cell
Casarotto PC,Girych M,Fred SM,Kovaleva V,Moliner R,Enkavi G,Biojone C,Cannarozzo C,Sahu MP,Kaurinkoski K,Brunello CA,Steinzeig A,Winkel F,Patil S,Vestring S,Serchov T,Diniz CRAF,Laukkanen L,Cardon I,Antila H,Rog T,Piepponen TP,Bramham CR,Normann C,Lauri SE,Saarma M,Vattulainen I,Castrén E
Thu Mar 04 00:00:00 EST 2021
H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model.
Cancer cell
Haag D,Mack N,Benites Goncalves da Silva P,Statz B,Clark J,Tanabe K,Sharma T,Jäger N,Jones DTW,Kawauchi D,Wernig M,Pfister SM
Mon Mar 08 00:00:00 EST 2021
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies.
Nature neuroscience
Kang Y,Zhou Y,Li Y,Han Y,Xu J,Niu W,Li Z,Liu S,Feng H,Huang W,Duan R,Xu T,Raj N,Zhang F,Dou J,Xu C,Wu H,Bassell GJ,Warren ST,Allen EG,Jin P,Wen Z
Fri Oct 01 00:00:00 EDT 2021
Long-term maturation of human cortical organoids matches key early postnatal transitions.
Nature neuroscience
Gordon A,Yoon SJ,Tran SS,Makinson CD,Park JY,Andersen J,Valencia AM,Horvath S,Xiao X,Huguenard JR,Pașca SP,Geschwind DH
450-02 was used in Cell Culture to suggest that important components of an intrinsic in vivo developmental program persist in vitro.
Mon Mar 01 00:00:00 EST 2021
Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function.
Cell stem cell
Xiong M,Tao Y,Gao Q,Feng B,Yan W,Zhou Y,Kotsonis TA,Yuan T,You Z,Wu Z,Xi J,Haberman A,Graham J,Block J,Zhou W,Chen Y,Zhang SC
Thu Jan 07 00:00:00 EST 2021
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs.
Cell stem cell
Cates K,McCoy MJ,Kwon JS,Liu Y,Abernathy DG,Zhang B,Liu S,Gontarz P,Kim WK,Chen S,Kong W,Ho JN,Burbach KF,Gabel HW,Morris SA,Yoo AS
Thu Jan 07 00:00:00 EST 2021
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs.
Cell stem cell
Cates K,McCoy MJ,Kwon JS,Liu Y,Abernathy DG,Zhang B,Liu S,Gontarz P,Kim WK,Chen S,Kong W,Ho JN,Burbach KF,Gabel HW,Morris SA,Yoo AS
Thu Jan 07 00:00:00 EST 2021
Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy.
Molecular cell
Ordureau A,Kraus F,Zhang J,An H,Park S,Ahfeldt T,Paulo JA,Harper JW
Thu Dec 16 00:00:00 EST 2021
Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease.
Neuron
Wang M,Li A,Sekiya M,Beckmann ND,Quan X,Schrode N,Fernando MB,Yu A,Zhu L,Cao J,Lyu L,Horgusluoglu E,Wang Q,Guo L,Wang YS,Neff R,Song WM,Wang E,Shen Q,Zhou X,Ming C,Ho SM,Vatansever S,Kaniskan HÜ,Jin J,Zhou MM,Ando K,Ho L,Slesinger PA,Yue Z,Zhu J,Katsel P,Gandy S,Ehrlich ME,Fossati V,Noggle S,Cai D,Haroutunian V,Iijima KM,Schadt E,Brennand KJ,Zhang B
450-02 was used in In vitro experiments to provide not only a global landscape but also detailed signaling circuits of complex molecular interactions in key brain regions affected by LOAD, and the resulting network models will serve as a blueprint for developing next-generation therapeutic agents against LOAD.
Wed Jan 20 00:00:00 EST 2021
Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors.
Neuron
Lagomarsino VN,Pearse RV,Liu L,Hsieh YC,Fernandez MA,Vinton EA,Paull D,Felsky D,Tasaki S,Gaiteri C,Vardarajan B,Lee H,Muratore CR,Benoit CR,Chou V,Fancher SB,He A,Merchant JP,Duong DM,Martinez H,Zhou M,Bah F,Vicent MA,Stricker JMS,Xu J,Dammer EB,Levey AI,Chibnik LB,Menon V,Seyfried NT,De Jager PL,Noggle S,Selkoe DJ,Bennett DA,Young-Pearse TL
Wed Nov 03 00:00:00 EDT 2021
Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction.
Brain : a journal of neurology
Van Lent J,Verstraelen P,Asselbergh B,Adriaenssens E,Mateiu L,Verbist C,De Winter V,Eggermont K,Van Den Bosch L,De Vos WH,Timmerman V
450-02 was used in Cell Culture to reveal shared cellular phenotypes across different CMT2 subtypes and suggests that targeting such common pathomechanisms could allow the development of a uniform treatment for CMT2.
Sat Sep 04 00:00:00 EDT 2021
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.
EMBO molecular medicine
Emmenegger M,De Cecco E,Hruska-Plochan M,Eninger T,Schneider MM,Barth M,Tantardini E,de Rossi P,Bacioglu M,Langston RG,Kaganovich A,Bengoa-Vergniory N,Gonzalez-Guerra A,Avar M,Heinzer D,Reimann R,Häsler LM,Herling TW,Matharu NS,Landeck N,Luk K,Melki R,Kahle PJ,Hornemann S,Knowles TPJ,Cookson MR,Polymenidou M,Jucker M,Aguzzi A
Tue Sep 07 00:00:00 EDT 2021
Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids.
EMBO molecular medicine
Trujillo CA,Adams JW,Negraes PD,Carromeu C,Tejwani L,Acab A,Tsuda B,Thomas CA,Sodhi N,Fichter KM,Romero S,Zanella F,Sejnowski TJ,Ulrich H,Muotri AR
Mon Jan 11 00:00:00 EST 2021
Modeling genetic epileptic encephalopathies using brain organoids.
EMBO molecular medicine
Steinberg DJ,Repudi S,Saleem A,Kustanovich I,Viukov S,Abudiab B,Banne E,Mahajnah M,Hanna JH,Stern S,Carlen PL,Aqeilan RI
Mon Aug 09 00:00:00 EDT 2021
SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function.
EMBO molecular medicine
Bae M,Roh JD,Kim Y,Kim SS,Han HM,Yang E,Kang H,Lee S,Kim JY,Kang R,Jung H,Yoo T,Kim H,Kim D,Oh H,Han S,Kim D,Han J,Bae YC,Kim H,Ahn S,Chan AM,Lee D,Kim JW,Kim E
Fri Feb 05 00:00:00 EST 2021
Targeted attenuation of elevated histone marks at SNCA alleviates α-synuclein in Parkinson's disease.
EMBO molecular medicine
Guhathakurta S,Kim J,Adams L,Basu S,Song MK,Adler E,Je G,Fiadeiro MB,Kim YS
Fri Feb 05 00:00:00 EST 2021
Widespread displacement of DNA- and RNA-binding factors underlies toxicity of arginine-rich cell-penetrating peptides.
The EMBO journal
Lafarga V,Sirozh O,Díaz-López I,Galarreta A,Hisaoka M,Zarzuela E,Boskovic J,Jovanovic B,Fernandez-Leiro R,Muñoz J,Stoecklin G,Ventoso I,Fernandez-Capetillo O
450-02 was used in Cell Culture to show that the toxicity of arginine-rich-cell-penetrating peptides is due to displacement of RNA- and DNA- binding factors from chromatin and mRNA.
Thu Jul 01 00:00:00 EDT 2021
A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome.
Molecular psychiatry
Cursano S,Battaglia CR,Urrutia-Ruiz C,Grabrucker S,Schön M,Bockmann J,Braumüller S,Radermacher P,Roselli F,Huber-Lang M,Boeckers TM
450-02 was used in In vitro experiments to employ a thoracic trauma (TxT) mouse model and thoroughly analyzed age-dependent spatial and temporal posttraumatic alterations in the central nervous system.
Sun Aug 01 00:00:00 EDT 2021
Impairment of the neurotrophic signaling hub B-Raf contributes to motoneuron degeneration in spinal muscular atrophy.
Proceedings of the National Academy of Sciences of the United States of America
Hensel N,Cieri F,Santonicola P,Tapken I,Schüning T,Taiana M,Pagliari E,Joseph A,Fischer S,Heidrich N,Brinkmann H,Kubinski S,Bergmann AK,Richter MF,Jung K,Corti S,Di Schiavi E,Claus P
Tue May 04 00:00:00 EDT 2021
Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes.
Current biology : CB
Boecker CA,Goldsmith J,Dou D,Cajka GG,Holzbaur ELF
Mon May 24 00:00:00 EDT 2021
Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations.
Molecular therapy. Nucleic acids
Mora-Jimenez L,Valencia M,Sanchez-Carpintero R,Tønnesen J,Fadila S,Rubinstein M,Gonzalez-Aparicio M,Bunuales M,Fernandez-Pierola E,Nicolas MJ,Puerta E,Miguelez C,Minguez PG,Lumbreras S,Gonzalez-Aseguinolaza G,Ricobaraza A,Hernandez-Alcoceba R
Fri Sep 03 00:00:00 EDT 2021
Human cell transformation by combined lineage conversion and oncogene expression.
Oncogene
Sahu B,Pihlajamaa P,Zhang K,Palin K,Ahonen S,Cervera A,Ristimäki A,Aaltonen LA,Hautaniemi S,Taipale J
Wed Sep 01 00:00:00 EDT 2021
Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Stertz L,Di Re J,Pei G,Fries GR,Mendez E,Li S,Smith-Callahan L,Raventos H,Tipo J,Cherukuru R,Zhao Z,Liu Y,Jia P,Laezza F,Walss-Bass C
Mon Feb 01 00:00:00 EST 2021
Premigratory neural crest stem cells generate enteric neurons populating the mouse colon and regulating peristalsis in tissue-engineered intestine.
Stem cells translational medicine
Yuan H,Hu H,Chen R,Mu W,Wang L,Li Y,Chen Y,Ding X,Xi Y,Mao S,Jiang M,Chen J,He Y,Wang L,Dong Y,Tou J,Chen W
Tue Jun 01 00:00:00 EDT 2021
Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media.
Acta pharmacologica Sinica
Zeng P,Hua QH,Gong JY,Shi CJ,Pi XP,Xie X,Zhang R
450-02 was used in Cell Culture to suggest that neonatal astrocytes from certain brain regions possess intrinsic potential to differentiate/transdifferentiate into neurons which may have clinical relevance in the future.
Mon Nov 01 00:00:00 EDT 2021
APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ramakrishna S,Jhaveri V,Konings SC,Nawalpuri B,Chakraborty S,Holst B,Schmid B,Gouras GK,Freude KK,Muddashetty RS
450-02 was used in Cell Culture to show that the defective protein synthesis mediated by APOE4 is closely linked to the perturbation of calcium homeostasis caused by APOE4 in neurons.
Wed Oct 20 00:00:00 EDT 2021
Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.
Cancer science
Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K
450-02 was used in Cell Culture to propose a mechanism of neuroblastoma transdifferentiation induced by extracellular growth factors, which can be controlled in clinical situations, providing a new therapeutic possibility.
Mon Feb 01 00:00:00 EST 2021
Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.
Cancer science
Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K
450-02 was used in Cell Culture to propose a mechanism of neuroblastoma transdifferentiation induced by extracellular growth factors, which can be controlled in clinical situations, providing a new therapeutic possibility.
Mon Feb 01 00:00:00 EST 2021
Extracellular Vesicles in Serum and Central Nervous System Tissues Contain microRNA Signatures in Sporadic Amyotrophic Lateral Sclerosis.
Frontiers in molecular neuroscience
Lo TW,Figueroa-Romero C,Hur J,Pacut C,Stoll E,Spring C,Lewis R,Nair A,Goutman SA,Sakowski SA,Nagrath S,Feldman EL
450-02 was used in In vitro experiments to study the role of circulating extracellular vesicles in the pathogenesis of amyotrophic lateral sclerosis.
Wed Nov 17 00:00:00 EST 2021
Allele-Specific Gene Editing Rescues Pathology in a Human Model of Charcot-Marie-Tooth Disease Type 2E.
Frontiers in cell and developmental biology
Feliciano CM,Wu K,Watry HL,Marley CBE,Ramadoss GN,Ghanim HY,Liu AZ,Zholudeva LV,McDevitt TC,Saporta MA,Conklin BR,Judge LM
450-02 was used in Cell Culture to study how allele-specific CRISPR gene editing in a human model of axonal Charcot-Marie-Tooth (CMT) disease rescues pathology caused by a dominant missense mutation in the neurofilament light chain gene (NEFL, CMT type 2E).
Thu Sep 07 00:00:00 EDT 2023
Altered cytoskeletal arrangement in induced pluripotent stem cells (iPSCs) and motor neurons from patients with riboflavin transporter deficiency.
Disease models & mechanisms
Niceforo A,Marioli C,Colasuonno F,Petrini S,Massey K,Tartaglia M,Bertini E,Moreno S,Compagnucci C
450-02 was used in Cell Culture to show that RF administration resulted in partially improved cytoskeletal features in patients' iPSCs and MNs.
Tue Jan 19 00:00:00 EST 2021
Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel.
Clinical and translational science
Xiong C,Chua KC,Stage TB,Priotti J,Kim J,Altman-Merino A,Chan D,Saraf K,Canato Ferracini A,Fattahi F,Kroetz DL
Mon Mar 01 00:00:00 EST 2021
Induction of Ventral Spinal V0 Interneurons from Mouse Embryonic Stem Cells.
Stem cells and development
Pardieck J,Harb M,Sakiyama-Elbert S
450-02 was used in Cell Culture to investigate V0 interneuron isolation to improve understanding of spinal central pattern generators.
Sun Aug 15 00:00:00 EDT 2021
Cholesterol-recognition motifs in the transmembrane domain of the tyrosine kinase receptor family: The case of TRKB.
The European journal of neuroscience
Cannarozzo C,Fred SM,Girych M,Biojone C,Enkavi G,Róg T,Vattulainen I,Casarotto PC,Castrén E
Sat May 01 00:00:00 EDT 2021
Electroacupuncture Promotes the Survival of the Grafted Human MGE Neural Progenitors in Rats with Cerebral Ischemia by Promoting Angiogenesis and Inhibiting Inflammation.
Neural plasticity
Li J,Chen L,Li D,Lu M,Huang X,Han X,Chen H
Wed Mar 02 00:00:00 EST 2022
Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.
Cell reports
Raj N,McEachin ZT,Harousseau W,Zhou Y,Zhang F,Merritt-Garza ME,Taliaferro JM,Kalinowska M,Marro SG,Hales CM,Berry-Kravis E,Wolf-Ochoa MW,Martinez-Cerdeño V,Wernig M,Chen L,Klann E,Warren ST,Jin P,Wen Z,Bassell GJ
Tue Apr 13 00:00:00 EDT 2021
In Vitro Generation of Posterior Motor Neurons from Human Pluripotent Stem Cells.
Current protocols
Wind M,Tsakiridis A
Wed Sep 01 00:00:00 EDT 2021
The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1.
Cell reports
Walter J,Bolognin S,Poovathingal SK,Magni S,Gérard D,Antony PMA,Nickels SL,Salamanca L,Berger E,Smits LM,Grzyb K,Perfeito R,Hoel F,Qing X,Ohnmacht J,Bertacchi M,Jarazo J,Ignac T,Monzel AS,Gonzalez-Cano L,Krüger R,Sauter T,Studer M,de Almeida LP,Tronstad KJ,Sinkkonen L,Skupin A,Schwamborn JC
Tue Oct 19 00:00:00 EDT 2021
Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment.
Cell reports
Dong X,Yang L,Liu K,Ji X,Tang C,Li W,Ma L,Mei Y,Peng T,Feng B,Wu Z,Tang Q,Gao Y,Yan K,Zhou W,Xiong M
Tue Mar 02 00:00:00 EST 2021
Generation of caudal-type serotonin neurons and hindbrain-fate organoids from hPSCs.
Stem cell reports
Valiulahi P,Vidyawan V,Puspita L,Oh Y,Juwono VB,Sittipo P,Friedlander G,Yahalomi D,Sohn JW,Lee YK,Yoon JK,Shim JW
Tue Aug 10 00:00:00 EDT 2021
Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition.
Stem cell reports
Stoklund Dittlau K,Krasnow EN,Fumagalli L,Vandoorne T,Baatsen P,Kerstens A,Giacomazzi G,Pavie B,Rossaert E,Beckers J,Sampaolesi M,Van Damme P,Van Den Bosch L
Tue Sep 14 00:00:00 EDT 2021
Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2.
Scientific reports
Boshans LL,Soh H,Wood WM,Nolan TM,Mandoiu II,Yanagawa Y,Tzingounis AV,Nishiyama A
Thu Feb 11 00:00:00 EST 2021
One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2.
Stem cell reports
Chanoumidou K,Hernández-Rodríguez B,Windener F,Thomas C,Stehling M,Mozafari S,Albrecht S,Ottoboni L,Antel J,Kim KP,Velychko S,Cui QL,Xu YKT,Martino G,Winkler J,Schöler HR,Baron-Van Evercooren A,Boespflug-Tanguy O,Vaquerizas JM,Ehrlich M,Kuhlmann T
Tue Apr 13 00:00:00 EDT 2021
Circ-Hdgfrp3 shuttles along neurites and is trapped in aggregates formed by ALS-associated mutant FUS.
iScience
D'Ambra E,Santini T,Vitiello E,D'Uva S,Silenzi V,Morlando M,Bozzoni I
450-02 was used in In vitro experiments to investigate Circ-Hdgfrp3 and its association with motor neurons carrying ALS-associated FUS mutations.
Fri Dec 17 00:00:00 EST 2021
Klotho inhibits neuronal senescence in human brain organoids.
NPJ aging and mechanisms of disease
Shaker MR,Aguado J,Chaggar HK,Wolvetang EJ
Mon Aug 02 00:00:00 EDT 2021
Bioengineered model of the human motor unit with physiologically functional neuromuscular junctions.
Scientific reports
Rimington RP,Fleming JW,Capel AJ,Wheeler PC,Lewis MP
Thu Jun 03 00:00:00 EDT 2021
Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure.
Translational psychiatry
Sheridan SD,Thanos JM,De Guzman RM,McCrea LT,Horng JE,Fu T,Sellgren CM,Perlis RH,Edlow AG
Fri Mar 19 00:00:00 EDT 2021
ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma.
Cell reports
De Bacco F,Orzan F,Erriquez J,Casanova E,Barault L,Albano R,D'Ambrosio A,Bigatto V,Reato G,Patanè M,Pollo B,Kuesters G,Dell'Aglio C,Casorzo L,Pellegatta S,Finocchiaro G,Comoglio PM,Boccaccio C
Tue Jul 27 00:00:00 EDT 2021
Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons.
Translational psychiatry
Hara T,Toyoshima M,Hisano Y,Balan S,Iwayama Y,Aono H,Futamura Y,Osada H,Owada Y,Yoshikawa T
Sat May 08 00:00:00 EDT 2021
SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells.
Cell death & disease
Lai X,Liu J,Zou Z,Wang Y,Wang Y,Liu X,Huang W,Ma Y,Chen Q,Li F,Wu G,Li W,Wang W,Yuan Y,Jiang B
Fri Aug 27 00:00:00 EDT 2021
Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia.
Nature communications
Bassil R,Shields K,Granger K,Zein I,Ng S,Chih B
Wed Sep 01 00:00:00 EDT 2021
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.
Scientific reports
Cheng C,Reis SA,Adams ET,Fass DM,Angus SP,Stuhlmiller TJ,Richardson J,Olafson H,Wang ET,Patnaik D,Beauchamp RL,Feldman DA,Silva MC,Sur M,Johnson GL,Ramesh V,Miller BL,Temple S,Kosik KS,Dickerson BC,Haggarty SJ
Mon Aug 23 00:00:00 EDT 2021
Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury.
Cell reports
Gong C,Zheng X,Guo F,Wang Y,Zhang S,Chen J,Sun X,Shah SZA,Zheng Y,Li X,Yin Y,Li Q,Huang X,Guo T,Han X,Zhang SC,Wang W,Chen H
Tue Mar 23 00:00:00 EDT 2021
Epigenetic Small Molecules Rescue Nucleocytoplasmic Transport and DNA Damage Phenotypes in C9ORF72 ALS/FTD.
Brain sciences
Ramic M,Andrade NS,Rybin MJ,Esanov R,Wahlestedt C,Benatar M,Zeier Z
450-02 was used in Cell Culture to characterize the nucleocytoplasmic transport and increased DNA damage disturbances and determine the relative contribution of different dipeptide repeat proteins (DPRs) needed to facilitate the development of novel therapeutics for C9ALS/ frontotemporal dementia (FTD).
Sat Nov 20 00:00:00 EST 2021
Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes.
Stem cell reports
Vadodaria KC,Mendes APD,Mei A,Racha V,Erikson G,Shokhirev MN,Oefner R,Heard KJ,McCarthy MJ,Eyler L,Kelsoe JR,Santos R,Marchetto MC,Gage FH
Tue Apr 13 00:00:00 EDT 2021
Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated.
Scientific reports
Singh T,Jiao Y,Ferrando LM,Yablonska S,Li F,Horoszko EC,Lacomis D,Friedlander RM,Carlisle DL
Thu Sep 23 00:00:00 EDT 2021
Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.
Cell reports
Kempf J,Knelles K,Hersbach BA,Petrik D,Riedemann T,Bednarova V,Janjic A,Simon-Ebert T,Enard W,Smialowski P,Götz M,Masserdotti G
Tue Jul 20 00:00:00 EDT 2021
Sterol auto-oxidation adversely affects human motor neuron viability and is a neuropathological feature of amyotrophic lateral sclerosis.
Scientific reports
Dodge JC,Yu J,Sardi SP,Shihabuddin LS
Tue Jan 12 00:00:00 EST 2021
Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.
eLife
Conde-Dusman MJ,Dey PN,Elía-Zudaire Ó,Rabaneda LG,García-Lira C,Grand T,Briz V,Velasco ER,Andero R,Niñerola S,Barco A,Paoletti P,Wesseling JF,Gardoni F,Tavalin SJ,Perez-Otaño I
450-02 was used in Cell Culture to investigate synapse modifications in memory.
Wed Nov 17 00:00:00 EST 2021
Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation.
Developmental cell
Yang W,Pang D,Chen M,Du C,Jia L,Wang L,He Y,Jiang W,Luo L,Yu Z,Mao M,Yuan Q,Tang P,Xia X,Cui Y,Jing B,Platero A,Liu Y,Wei Y,Worley PF,Xiao B
450-02 was used in Cell Culture to identify Rheb as a nodal point that balances neuronal activity and neuroenergetics via Rheb-PDH axis.
Mon Mar 22 00:00:00 EDT 2021
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response.
Cell stem cell
Wang C,Zhang M,Garcia G,Tian E,Cui Q,Chen X,Sun G,Wang J,Arumugaswami V,Shi Y
450-02 was used in In vitro experiments to study whether ApoE4 alters COVID-19 susceptibility or severity and the role of direct viral infection in brain cells to suggest that ApoE4 may play a causal role in COVID-19 severity.
Thu Feb 04 00:00:00 EST 2021
Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.
FEBS open bio
Fukusumi H,Togo K,Sumida M,Nakamori M,Obika S,Baba K,Shofuda T,Ito D,Okano H,Mochizuki H,Kanemura Y
Mon Feb 01 00:00:00 EST 2021
Differentiation of human adult-derived stem cells towards a neural lineage involves a dedifferentiation event prior to differentiation to neural phenotypes.
Scientific reports
Bueno C,Martínez-Morga M,García-Bernal D,Moraleda JM,Martínez S
Tue Jun 08 00:00:00 EDT 2021
16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro.
Nature communications
Sundberg M,Pinson H,Smith RS,Winden KD,Venugopal P,Tai DJC,Gusella JF,Talkowski ME,Walsh CA,Tegmark M,Sahin M
Tue May 18 00:00:00 EDT 2021
Select neurotrophins promote oligodendrocyte progenitor cell process outgrowth in the presence of chondroitin sulfate proteoglycans.
Journal of neuroscience research
Siebert JR,Osterhout DJ
Thu Apr 01 00:00:00 EDT 2021
PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons.
Scientific reports
Brown SJ,Boussaad I,Jarazo J,Fitzgerald JC,Antony P,Keatinge M,Blechman J,Schwamborn JC,Krüger R,Placzek M,Bandmann O
Tue Mar 23 00:00:00 EDT 2021
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Nature communications
Hu D,Sun X,Magpusao A,Fedorov Y,Thompson M,Wang B,Lundberg K,Adams DJ,Qi X
Mon Sep 06 00:00:00 EDT 2021
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients.
iScience
Li J,Lim RG,Kaye JA,Dardov V,Coyne AN,Wu J,Milani P,Cheng A,Thompson TG,Ornelas L,Frank A,Adam M,Banuelos MG,Casale M,Cox V,Escalante-Chong R,Daigle JG,Gomez E,Hayes L,Holewenski R,Lei S,Lenail A,Lima L,Mandefro B,Matlock A,Panther L,Patel-Murray NL,Pham J,Ramamoorthy D,Sachs K,Shelley B,Stocksdale J,Trost H,Wilhelm M,Venkatraman V,Wassie BT,Wyman S,Yang S,Van Eyk JE,Lloyd TE,Finkbeiner S,Fraenkel E,Rothstein JD,Sareen D,Svendsen CN,Thompson LM
Fri Nov 19 00:00:00 EST 2021
A Propagated Skeleton Approach to High Throughput Screening of Neurite Outgrowth for In Vitro Parkinson's Disease Modelling.
Cells
Schikora J,Kiwatrowski N,Förster N,Selbach L,Ostendorf F,Pallapies F,Hasse B,Metzdorf J,Gold R,Mosig A,Tönges L
450-02 was used in Cell Culture to investigate neuronal outgrowth computer screening from fluorescent microscopy in neurodegenerative diseases.
Sat Apr 17 00:00:00 EDT 2021
Early Transcriptional Changes in Rabies Virus-Infected Neurons and Their Impact on Neuronal Functions.
Frontiers in microbiology
Kim S,Larrous F,Varet H,Legendre R,Feige L,Dumas G,Matsas R,Kouroupi G,Grailhe R,Bourhy H
450-02 was used in Cell Culture to study neuronal dysfunctions in the context of rabies virus (RABV) using differentiated neurons to characterize the RABV-induced transcriptomic changes at the early time-points of infection.
Sat Jan 01 00:00:00 EST 2022
Identification of Novel Positive Allosteric Modulators of Neurotrophin Receptors for the Treatment of Cognitive Dysfunction.
Cells
Dahlström M,Madjid N,Nordvall G,Halldin MM,Vazquez-Juarez E,Lindskog M,Sandin J,Winblad B,Eriksdotter M,Forsell P
450-02 was used in In vitro experiments to identify small molecules with stimulatory effects on the signaling of two neurotrophins, the nerve growth factor (NGF) and the brain derived neurotrophic factor (BDNF).
Fri Jul 23 00:00:00 EDT 2021
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons.
Communications biology
Sanchez CG,Acker CM,Gray A,Varadarajan M,Song C,Cochran NR,Paula S,Lindeman A,An S,McAllister G,Alford J,Reece-Hoyes J,Russ C,Craig L,Capre K,Doherty C,Hoffman GR,Luchansky SJ,Polydoro M,Dolmetsch R,Elwood F
Mon Jun 14 00:00:00 EDT 2021
Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons.
Nature communications
Kim SG,Lee S,Kim Y,Park J,Woo D,Kim D,Li Y,Shin W,Kang H,Yook C,Lee M,Kim K,Roh JD,Ryu J,Jung H,Um SM,Yang E,Kim H,Han J,Heo WD,Kim E
Tue May 11 00:00:00 EDT 2021
MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling.
Cell reports
Nakashima H,Tsujimura K,Irie K,Imamura T,Trujillo CA,Ishizu M,Uesaka M,Pan M,Noguchi H,Okada K,Aoyagi K,Andoh-Noda T,Okano H,Muotri AR,Nakashima K
Tue May 18 00:00:00 EDT 2021
The difficulty to model Huntington's disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells.
Scientific reports
Le Cann K,Foerster A,Rösseler C,Erickson A,Hautvast P,Giesselmann S,Pensold D,Kurth I,Rothermel M,Mattis VB,Zimmer-Bensch G,von Hörsten S,Denecke B,Clarner T,Meents J,Lampert A
Thu Mar 25 00:00:00 EDT 2021
Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.
Cell reports. Medicine
Pandya NJ,Wang C,Costa V,Lopatta P,Meier S,Zampeta FI,Punt AM,Mientjes E,Grossen P,Distler T,Tzouros M,Martí Y,Banfai B,Patsch C,Rasmussen S,Hoener M,Berrera M,Kremer T,Dunkley T,Ebeling M,Distel B,Elgersma Y,Jagasia R
Tue Aug 17 00:00:00 EDT 2021
A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation.
Nature metabolism
Li L,Conradson DM,Bharat V,Kim MJ,Hsieh CH,Minhas PS,Papakyrikos AM,Durairaj AS,Ludlam A,Andreasson KI,Partridge L,Cianfrocco MA,Wang X
Wed Sep 01 00:00:00 EDT 2021
3D Bioprinting Mesenchymal Stem Cell-Derived Neural Tissues Using a Fibrin-Based Bioink.
Biomolecules
Restan Perez M,Sharma R,Masri NZ,Willerth SM
450-02 was used in Cell Culture to show the potential of bioprinting engineered neural tissues from patient-derived MSCs, which could serve as an important tool for personalized disease models and drug-screening.
Sat Aug 21 00:00:00 EDT 2021
Deficiency in MT5-MMP Supports Branching of Human iPSCs-Derived Neurons and Reduces Expression of GLAST/S100 in iPSCs-Derived Astrocytes.
Cells
Arnst N,Belio-Mairal P,García-González L,Arnaud L,Greetham L,Nivet E,Rivera S,Dityatev A
450-02 was used in Cell Culture to investigate the effects of MT5-MMP deficiency on neurons and glia using human-induced pluripotent stem cells.
Tue Jul 06 00:00:00 EDT 2021
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Autophagy
Richard P,Feng S,Tsai YL,Li W,Rinchetti P,Muhith U,Irizarry-Cole J,Stolz K,Sanz LA,Hartono S,Hoque M,Tadesse S,Seitz H,Lotti F,Hirano M,Chédin F,Tian B,Manley JL
450-02 was used in Cell Culture to study how mutations in the same SETX (senataxin) protein can lead to different phenotypes.
Sun Aug 01 00:00:00 EDT 2021
BASP1 labels neural stem cells in the neurogenic niches of mammalian brain.
Scientific reports
Manganas LN,Durá I,Osenberg S,Semerci F,Tosun M,Mishra R,Parkitny L,Encinas JM,Maletic-Savatic M
Wed Mar 10 00:00:00 EST 2021
CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity.
iScience
Dias C,Nita E,Faktor J,Tynan AC,Hernychova L,Vojtesek B,Nylandsted J,Hupp TR,Kunath T,Ball KL
Fri Aug 20 00:00:00 EDT 2021
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.
Nature communications
Prelli Bozzo C,Nchioua R,Volcic M,Koepke L,Krüger J,Schütz D,Heller S,Stürzel CM,Kmiec D,Conzelmann C,Müller J,Zech F,Braun E,Groß R,Wettstein L,Weil T,Weiß J,Diofano F,Rodríguez Alfonso AA,Wiese S,Sauter D,Münch J,Goffinet C,Catanese A,Schön M,Boeckers TM,Stenger S,Sato K,Just S,Kleger A,Sparrer KMJ,Kirchhoff F
Wed Jul 28 00:00:00 EDT 2021
Deep learning-based predictive identification of neural stem cell differentiation.
Nature communications
Zhu Y,Huang R,Wu Z,Song S,Cheng L,Zhu R
Mon May 10 00:00:00 EDT 2021
Deep learning-based predictive identification of neural stem cell differentiation.
Nature communications
Zhu Y,Huang R,Wu Z,Song S,Cheng L,Zhu R
Mon May 10 00:00:00 EDT 2021
ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.
Communications biology
Garone MG,Birsa N,Rosito M,Salaris F,Mochi M,de Turris V,Nair RR,Cunningham TJ,Fisher EMC,Morlando M,Fratta P,Rosa A
Wed Sep 01 00:00:00 EDT 2021
Robust neuronal differentiation of human iPSC-derived neural progenitor cells cultured on densely-spaced spiky silicon nanowire arrays.
Scientific reports
Harberts J,Siegmund M,Schnelle M,Zhang T,Lei Y,Yu L,Zierold R,Blick RH
Wed Sep 22 00:00:00 EDT 2021
α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology.
Cell reports
Stykel MG,Humphries KM,Kamski-Hennekam E,Buchner-Duby B,Porte-Trachsel N,Ryan T,Coackley CL,Bamm VV,Harauz G,Ryan SD
Tue May 11 00:00:00 EDT 2021
SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome.
Nature communications
Banfi F,Rubio A,Zaghi M,Massimino L,Fagnocchi G,Bellini E,Luoni M,Cancellieri C,Bagliani A,Di Resta C,Maffezzini C,Ianielli A,Ferrari M,Piazza R,Mologni L,Broccoli V,Sessa A
Wed Jun 30 00:00:00 EDT 2021
Facilitation of TRKB Activation by the Angiotensin II Receptor Type-2 (AT2R) Agonist C21.
Pharmaceuticals (Basel, Switzerland)
Laukkanen L,Diniz CRAF,Foulquier S,Prickaerts J,Castrén E,Casarotto PC
450-02 was used in In vivo experiments to indicate that AT2R agonist C21 upregulates cell-surface expression of TRKB in BDNF-TRKB system, while reducing fear response of mice through a BDNF-dependant manner.
Fri Aug 06 00:00:00 EDT 2021
Parkinson's disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration.
NPJ Parkinson's disease
Carola G,Malagarriga D,Calatayud C,Pons-Espinal M,Blasco-Agell L,Richaud-Patin Y,Fernandez-Carasa I,Baruffi V,Beltramone S,Molina E,Dell'Era P,Toledo-Aral JJ,Tolosa E,Muotri AR,Garcia Ojalvo J,Soriano J,Raya A,Consiglio A
Fri Jul 02 00:00:00 EDT 2021
Parkinson's disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration.
NPJ Parkinson's disease
Carola G,Malagarriga D,Calatayud C,Pons-Espinal M,Blasco-Agell L,Richaud-Patin Y,Fernandez-Carasa I,Baruffi V,Beltramone S,Molina E,Dell'Era P,Toledo-Aral JJ,Tolosa E,Muotri AR,Garcia Ojalvo J,Soriano J,Raya A,Consiglio A
Fri Jul 02 00:00:00 EDT 2021
ATP-citrate lyase promotes axonal transport across species.
Nature communications
Even A,Morelli G,Turchetto S,Shilian M,Bail RL,Laguesse S,Krusy N,Brisker A,Brandis A,Inbar S,Chariot A,Saudou F,Dietrich P,Dragatsis I,Brone B,Broix L,Rigo JM,Weil M,Nguyen L
Thu Oct 07 00:00:00 EDT 2021
Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells.
eLife
Behesti H,Kocabas A,Buchholz DE,Carroll TS,Hatten ME
450-02 was used in Cell Culture to report a rapid protocol for the derivation of the human ATOH1 lineage, the precursor of excitatory cerebellar neurons, from human pluripotent stem cells (hPSCs).
Mon Nov 29 00:00:00 EST 2021
Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons.
Journal of visualized experiments : JoVE
Taga A,Habela CW,Johns A,Liu S,O'Brien M,Maragakis NJ
450-02 was used in Cell Culture to describe a method to co-culture spinal cord hiPSC-A with hiPSC-MN and record electrophysiological activity using MEA recordings.
Thu Aug 26 00:00:00 EDT 2021
Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis.
Cell reports
Wegscheid ML,Anastasaki C,Hartigan KA,Cobb OM,Papke JB,Traber JN,Morris SM,Gutmann DH
Tue Jul 06 00:00:00 EDT 2021
Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder.
Nature communications
Kour S,Rajan DS,Fortuna TR,Anderson EN,Ward C,Lee Y,Lee S,Shin YB,Chae JH,Choi M,Siquier K,Cantagrel V,Amiel J,Stolerman ES,Barnett SS,Cousin MA,Castro D,McDonald K,Kirmse B,Nemeth AH,Rajasundaram D,Innes AM,Lynch D,Frosk P,Collins A,Gibbons M,Yang M,Desguerre I,Boddaert N,Gitiaux C,Rydning SL,Selmer KK,Urreizti R,Garcia-Oguiza A,Osorio AN,Verdura E,Pujol A,McCurry HR,Landers JE,Agnihotri S,Andriescu EC,Moody SB,Phornphutkul C,Sacoto MJG,Begtrup A,Houlden H,Kirschner J,Schorling D,Rudnik-Schöneborn S,Strom TM,Leiz S,Juliette K,Richardson R,Yang Y,Zhang Y,Wang M,Wang J,Wang X,Platzer K,Donkervoort S,Bönnemann CG,Wagner M,Issa MY,Elbendary HM,Stanley V,Maroofian R,Gleeson JG,Zaki MS,Senderek J,Pandey UB
Fri May 07 00:00:00 EDT 2021
Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder.
Nature communications
Kour S,Rajan DS,Fortuna TR,Anderson EN,Ward C,Lee Y,Lee S,Shin YB,Chae JH,Choi M,Siquier K,Cantagrel V,Amiel J,Stolerman ES,Barnett SS,Cousin MA,Castro D,McDonald K,Kirmse B,Nemeth AH,Rajasundaram D,Innes AM,Lynch D,Frosk P,Collins A,Gibbons M,Yang M,Desguerre I,Boddaert N,Gitiaux C,Rydning SL,Selmer KK,Urreizti R,Garcia-Oguiza A,Osorio AN,Verdura E,Pujol A,McCurry HR,Landers JE,Agnihotri S,Andriescu EC,Moody SB,Phornphutkul C,Sacoto MJG,Begtrup A,Houlden H,Kirschner J,Schorling D,Rudnik-Schöneborn S,Strom TM,Leiz S,Juliette K,Richardson R,Yang Y,Zhang Y,Wang M,Wang J,Wang X,Platzer K,Donkervoort S,Bönnemann CG,Wagner M,Issa MY,Elbendary HM,Stanley V,Maroofian R,Gleeson JG,Zaki MS,Senderek J,Pandey UB
Fri May 07 00:00:00 EDT 2021
Depression patient-derived cortical neurons reveal potential biomarkers for antidepressant response.
Translational psychiatry
Avior Y,Ron S,Kroitorou D,Albeldas C,Lerner V,Corneo B,Nitzan E,Laifenfeld D,Cohen Solal T
Thu Apr 01 00:00:00 EDT 2021
Transcriptional cooperation of PBX1 and PAX6 in adult neural progenitor cells.
Scientific reports
Hau AC,Mommaerts E,Laub V,Müller T,Dittmar G,Schulte D
Mon Oct 25 00:00:00 EDT 2021
Development of a specific live-cell assay for native autophagic flux.
The Journal of biological chemistry
Safren N,Tank EM,Malik AM,Chua JP,Santoro N,Barmada SJ
Wed Sep 01 00:00:00 EDT 2021
Self-assembling peptide scaffolds in the clinic.
NPJ Regenerative medicine
Gelain F,Luo Z,Rioult M,Zhang S
Wed Feb 17 00:00:00 EST 2021
STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia.
iScience
Morozzi G,Rothen J,Toussaint G,De Lange K,Westritschnig K,Doelemeyer A,Ueberschlag VP,Kahle P,Lambert C,Obrecht M,Beckmann N,Ritter V,Panesar M,Stauffer D,Garnier I,Mueller M,Guerini D,Keller CG,Knehr J,Roma G,Bidinosti M,Brachat S,Morvan F,Fornaro M
450-02 was used in In vitro experiments to investigate relationship between peripheral nerve injury and inflammation.
Fri Dec 17 00:00:00 EST 2021
7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis.
eLife
Xue F,Zhao Z,Gu Y,Han J,Ye K,Zhang Y
450-02 was used in In vitro experiments to study whether brain-derived neurotrophic factor (BDNF) is involved in osteoporosis related imbalances in bone formation and resorption.
Tue Jul 06 00:00:00 EDT 2021
Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.
Nature medicine
Khan TA,Revah O,Gordon A,Yoon SJ,Krawisz AK,Goold C,Sun Y,Kim CH,Tian Y,Li MY,Schaepe JM,Ikeda K,Amin ND,Sakai N,Yazawa M,Kushan L,Nishino S,Porteus MH,Rapoport JL,Bernstein JA,O'Hara R,Bearden CE,Hallmayer JF,Huguenard JR,Geschwind DH,Dolmetsch RE,Paşca SP
450-02 was used in Cell Culture to illustrate how stem cell derived models can be used to uncover and rescue cellular phenotypes associated with genetic forms of neuropsychiatric disease.
Tue Dec 01 00:00:00 EST 2020
Histone H3.3 phosphorylation amplifies stimulation-induced transcription.
Nature
Armache A,Yang S,Martínez de Paz A,Robbins LE,Durmaz C,Cheong JQ,Ravishankar A,Daman AW,Ahimovic DJ,Klevorn T,Yue Y,Arslan T,Lin S,Panchenko T,Hrit J,Wang M,Thudium S,Garcia BA,Korb E,Armache KJ,Rothbart SB,Hake SB,Allis CD,Li H,Josefowicz SZ
450-02 was used in Cell Culture to study how chromatin is regulated at induced genes, and what features of histone H3.3 might enable rapid and high-level transcription.
Wed Jul 01 00:00:00 EDT 2020
Functionally Distinct Neuronal Ensembles within the Memory Engram.
Cell
Sun X,Bernstein MJ,Meng M,Rao S,Sørensen AT,Yao L,Zhang X,Anikeeva PO,Lin Y
Thu Apr 16 00:00:00 EDT 2020
SARS-CoV-2 infects human neural progenitor cells and brain organoids.
Cell research
Zhang BZ,Chu H,Han S,Shuai H,Deng J,Hu YF,Gong HR,Lee AC,Zou Z,Yau T,Wu W,Hung IF,Chan JF,Yuen KY,Huang JD
Thu Oct 01 00:00:00 EDT 2020
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium.
Cell stem cell
Jacob F,Pather SR,Huang WK,Zhang F,Wong SZH,Zhou H,Cubitt B,Fan W,Chen CZ,Xu M,Pradhan M,Zhang DY,Zheng W,Bang AG,Song H,Carlos de la Torre J,Ming GL
Thu Dec 03 00:00:00 EST 2020
Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.
Molecular cell
Young-Baird SK,Lourenço MB,Elder MK,Klann E,Liebau S,Dever TE
450-02 was used in In vitro experiments to show that a mutation at the C terminus of eIF2γ impairs CDC123 promotion of eIF2 complex formation and decreases the level of eIF2-GTP-Met-tRNAiMet ternary complexes, using patient-derived induced pluripotent stem cells.
Thu Feb 20 00:00:00 EST 2020
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
Molecular cell
Sarraf SA,Shah HV,Kanfer G,Pickrell AM,Holtzclaw LA,Ward ME,Youle RJ
450-02 was used in Cell Culture to show that TAX1BP1 mediates clearance of a broad range of cytotoxic proteins indicating therapeutic potential in neurodegenerative diseases.
Thu Dec 03 00:00:00 EST 2020
Tau Reduction Prevents Key Features of Autism in Mouse Models.
Neuron
Tai C,Chang CW,Yu GQ,Lopez I,Yu X,Wang X,Guo W,Mucke L
Wed May 06 00:00:00 EDT 2020
Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36.
Neuron
McEachin ZT,Gendron TF,Raj N,García-Murias M,Banerjee A,Purcell RH,Ward PJ,Todd TW,Merritt-Garza ME,Jansen-West K,Hales CM,García-Sobrino T,Quintáns B,Holler CJ,Taylor G,San Millán B,Teijeira S,Yamashita T,Ohkubo R,Boulis NM,Xu C,Wen Z,Streichenberger N,Fogel BL,Kukar T,Abe K,Dickson DW,Arias M,Glass JD,Jiang J,Tansey MG,Sobrido MJ,Petrucelli L,Rossoll W,Bassell GJ
Wed Jul 22 00:00:00 EDT 2020
A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.
Neuron
Nguyen TA,Wu K,Pandey S,Lehr AW,Li Y,Bemben MA,Badger JD,Lauzon JL,Wang T,Zaghloul KA,Thurm A,Jain M,Lu W,Roche KW
Wed Jun 03 00:00:00 EDT 2020
G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Neuron
Coyne AN,Zaepfel BL,Hayes L,Fitchman B,Salzberg Y,Luo EC,Bowen K,Trost H,Aigner S,Rigo F,Yeo GW,Harel A,Svendsen CN,Sareen D,Rothstein JD
450-02 was used in Cell Culture to suggest that the expression of expanded C9orf72 ALS/FTD repeat RNA alone affects nuclear POM121 expression in the initiation of a pathological cascade affecting nucleoporin levels within neuronal nuclei and ultimately downstream neuronal survival.
Wed Sep 23 00:00:00 EDT 2020
Huntington's Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy.
Neuron
Fox LM,Kim K,Johnson CW,Chen S,Croce KR,Victor MB,Eenjes E,Bosco JR,Randolph LK,Dragatsis I,Dragich JM,Yoo AS,Yamamoto A
Wed Mar 04 00:00:00 EST 2020
Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.
Neuron
Henderson MX,Sedor S,McGeary I,Cornblath EJ,Peng C,Riddle DM,Li HL,Zhang B,Brown HJ,Olufemi MF,Bassett DS,Trojanowski JQ,Lee VMY
Wed Mar 04 00:00:00 EST 2020
Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations.
EMBO molecular medicine
Liang KX,Kristiansen CK,Mostafavi S,Vatne GH,Zantingh GA,Kianian A,Tzoulis C,Høyland LE,Ziegler M,Perez RM,Furriol J,Zhang Z,Balafkan N,Hong Y,Siller R,Sullivan GJ,Bindoff LA
Wed Oct 07 00:00:00 EDT 2020
Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway.
Proceedings of the National Academy of Sciences of the United States of America
Wang T,Medynets M,Johnson KR,Doucet-O'Hare TT,DiSanza B,Li W,Xu Y,Bagnell A,Tyagi R,Sampson K,Malik N,Steiner J,Hadegan A,Kowalak J,O'Malley J,Maric D,Nath A
Tue Jul 28 00:00:00 EDT 2020
Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice.
Proceedings of the National Academy of Sciences of the United States of America
Shen W,Wang QW,Liu YN,Marchetto MC,Linker S,Lu SY,Chen Y,Liu C,Guo C,Xing Z,Shi W,Kelsoe JR,Alda M,Wang H,Zhong Y,Sui SF,Zhao M,Yang Y,Mi S,Cao L,Gage FH,Yao J
Tue Feb 25 00:00:00 EST 2020
A single-cell Raman-based platform to identify developmental stages of human pluripotent stem cell-derived neurons.
Proceedings of the National Academy of Sciences of the United States of America
Hsu CC,Xu J,Brinkhof B,Wang H,Cui Z,Huang WE,Ye H
Tue Aug 04 00:00:00 EDT 2020
USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway.
Proceedings of the National Academy of Sciences of the United States of America
Zhang T,Periz G,Lu YN,Wang J
Tue Nov 10 00:00:00 EST 2020
Novel genetic features of human and mouse Purkinje cell differentiation defined by comparative transcriptomics.
Proceedings of the National Academy of Sciences of the United States of America
Buchholz DE,Carroll TS,Kocabas A,Zhu X,Behesti H,Faust PL,Stalbow L,Fang Y,Hatten ME
Tue Jun 30 00:00:00 EDT 2020
High-Throughput Screening and Hierarchical Topography-Mediated Neural Differentiation of Mesenchymal Stem Cells.
Advanced healthcare materials
Yang L,Jurczak KM,Ge L,van Rijn P
Mon Jun 01 00:00:00 EDT 2020
IGF1R regulates retrograde axonal transport of signalling endosomes in motor neurons.
EMBO reports
Fellows AD,Rhymes ER,Gibbs KL,Greensmith L,Schiavo G
Wed Mar 04 00:00:00 EST 2020
IGF1R regulates retrograde axonal transport of signalling endosomes in motor neurons.
EMBO reports
Fellows AD,Rhymes ER,Gibbs KL,Greensmith L,Schiavo G
Wed Mar 04 00:00:00 EST 2020
Saikosaponin-d impedes hippocampal neurogenesis and causes cognitive deficits by inhibiting the survival of neural stem/progenitor cells via neurotrophin receptor signaling in mice.
Clinical and translational medicine
Qin T,Yuan Z,Yu J,Fu X,Deng X,Fu Q,Ma Z,Ma S
Tue Dec 01 00:00:00 EST 2020
Conserved metabolite regulation of stress granule assembly via AdoMet.
The Journal of cell biology
Begovich K,Vu AQ,Yeo G,Wilhelm JE
Mon Aug 03 00:00:00 EDT 2020
Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral Sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dodge JC,Jensen EH,Yu J,Sardi SP,Bialas AR,Taksir TV,Bangari DS,Shihabuddin LS
450-02 was used in Cell Culture to show that cholesterol ester (CE) and triacylglycerol levels are elevated several-fold in the spinal cord GM of male sporadic ALS patients.
Wed Nov 18 00:00:00 EST 2020
In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo.
mAbs
Stack E,McMurray S,McMurray G,Wade J,Clark M,Young G,Marquette K,Jain S,Kelleher K,Chen T,Lin Q,Bloom L,Lin L,Finlay W,Suzuki R,Cunningham O
450-02 was used in ELISA Competitive to demonstrate that effective sequestration of BDNF via a high affinity neutralizing antibody has potential utility in modulating the pathophysiological mechanisms that drive chronic pain states.
Mon May 17 00:00:00 EDT 2021
Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid.
Frontiers in molecular neuroscience
Spampinato SF,Merlo S,Fagone E,Fruciano M,Sano Y,Kanda T,Sortino MA
450-02 was used in Cell Culture to show reciprocal crosstalk between infiltrating peripheral cells and astrocytes upon Aβ exposure.
Mon Sep 28 00:00:00 EDT 2020
3D Bioprinting Pluripotent Stem Cell Derived Neural Tissues Using a Novel Fibrin Bioink Containing Drug Releasing Microspheres.
Frontiers in bioengineering and biotechnology
Sharma R,Smits IPM,De La Vega L,Lee C,Willerth SM
Mon Nov 13 00:00:00 EST 2023
MiRNA-137-mediated modulation of mitochondrial dynamics regulates human neural stem cell fate.
Stem cells (Dayton, Ohio)
Channakkar AS,Singh T,Pattnaik B,Gupta K,Seth P,Adlakha YK
Fri May 01 00:00:00 EDT 2020
Polydatin promotes the neuronal differentiation of bone marrow mesenchymal stem cells in vitro and in vivo: Involvement of Nrf2 signalling pathway.
Journal of cellular and molecular medicine
Zhan J,Li X,Luo D,Hou Y,Hou Y,Chen S,Xiao Z,Luan J,Lin D
Fri May 01 00:00:00 EDT 2020
Reprogramming fibroblasts and peripheral blood cells from a C9ORF72 patient: A proof-of-principle study.
Journal of cellular and molecular medicine
Bardelli D,Sassone F,Colombrita C,Volpe C,Gumina V,Peverelli S,Catusi I,Ratti A,Silani V,Bossolasco P
Wed Apr 01 00:00:00 EDT 2020
Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors.
American journal of physiology. Cell physiology
Sepehrimanesh M,Ding B
Thu Oct 01 00:00:00 EDT 2020
Synaptic signalling in a network of dopamine neurons: what prevents proper intercellular crosstalk?
FEBS letters
Chen Y,Kunath T,Simpson J,Homer N,Sylantyev S
Thu Oct 01 00:00:00 EDT 2020
Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models.
Cell death & disease
de la Fuente S,Sansa A,Hidalgo I,Vivancos N,Romero-Guevara R,Garcera A,Soler RM
Thu Jun 25 00:00:00 EDT 2020
CCR3 antagonist protects against induced cellular senescence and promotes rejuvenation in periodontal ligament cells for stimulating pulp regeneration in the aged dog.
Scientific reports
Zayed M,Iohara K,Watanabe H,Nakashima M
Mon May 25 00:00:00 EDT 2020
Single-Cell Transcriptomics of Parkinson's Disease Human In Vitro Models Reveals Dopamine Neuron-Specific Stress Responses.
Cell reports
Fernandes HJR,Patikas N,Foskolou S,Field SF,Park JE,Byrne ML,Bassett AR,Metzakopian E
450-02 was used in Cell Culture to reveal cell type-specific perturbations in human dopamine neurons, which will further our understanding of PD and have implications for cell replacement therapies.
Tue Oct 13 00:00:00 EDT 2020
Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons.
Molecular cell
Xiang Y,Tanaka Y,Patterson B,Hwang SM,Hysolli E,Cakir B,Kim KY,Wang W,Kang YJ,Clement EM,Zhong M,Lee SH,Cho YS,Patra P,Sullivan GJ,Weissman SM,Park IH
450-02 was used in In vitro experiments to study the function of methyl-CpG binding protein 2 (MeCP2) using 2D and 3D human brain cultures.
Thu Jul 02 00:00:00 EDT 2020
X-ray irradiated cultures of mouse cortical neural stem/progenitor cells recover cell viability and proliferation with dose-dependent kinetics.
Scientific reports
Licursi V,Anzellotti S,Favaro J,Sineri S,Carucci N,Cundari E,Fiore M,Guarguaglini G,Pippa S,Nisi PS,Vernì F,Biagioni S,Cacci E,Amendola R,Lupo G,Negri R
Thu Apr 16 00:00:00 EDT 2020
Modelling human CNS injury with human neural stem cells in 2- and 3-Dimensional cultures.
Scientific reports
Vagaska B,Gillham O,Ferretti P
Wed Apr 22 00:00:00 EDT 2020
In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets.
Scientific reports
Vermilyea SC,Babinski A,Tran N,To S,Guthrie S,Kluss JH,Schmidt JK,Wiepz GJ,Meyer MG,Murphy ME,Cookson MR,Emborg ME,Golos TG
Wed Feb 26 00:00:00 EST 2020
Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction.
Scientific reports
Nzou G,Wicks RT,VanOstrand NR,Mekky GA,Seale SA,El-Taibany A,Wicks EE,Nechtman CM,Marrotte EJ,Makani VS,Murphy SV,Seeds MC,Jackson JD,Atala AJ
Wed Jun 17 00:00:00 EDT 2020
Rare Variant Burden Analysis within Enhancers Identifies CAV1 as an ALS Risk Gene.
Cell reports
Cooper-Knock J,Zhang S,Kenna KP,Moll T,Franklin JP,Allen S,Nezhad HG,Iacoangeli A,Yacovzada NY,Eitan C,Hornstein E,Elhaik E,Celadova P,Bose D,Farhan S,Fishilevich S,Lancet D,Morrison KE,Shaw CE,Al-Chalabi A,Veldink JH,Kirby J,Snyder MP,Shaw PJ
450-02 was used in Cell Culture to identify the pathogenic genetic variation within enhancer elements responsible for regulating gene expression.
Tue Dec 01 00:00:00 EST 2020
Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development.
STAR protocols
Xiang Y,Cakir B,Park IH
450-02 was used in Cell Culture to present a protocol to generate regionally specified human brain organoids that recapitulate the development of the thalamus using human pluripotent stem cells (hPSCs).
Fri Jun 19 00:00:00 EDT 2020
Photoactivatable Cre recombinase 3.0 for in vivo mouse applications.
Nature communications
Morikawa K,Furuhashi K,de Sena-Tomas C,Garcia-Garcia AL,Bekdash R,Klein AD,Gallerani N,Yamamoto HE,Park SE,Collins GS,Kawano F,Sato M,Lin CS,Targoff KL,Au E,Salling MC,Yazawa M
Fri May 01 00:00:00 EDT 2020
An iPSC-Derived Neuron Model of CLN3 Disease Facilitates Small Molecule Phenotypic Screening.
ACS pharmacology & translational science
Kinarivala N,Morsy A,Patel R,Carmona AV,Sajib MS,Raut S,Mikelis CM,Al-Ahmad A,Trippier PC
450-02 was used in Sample Preparation to report the characterization of the first CLN3 patient-specific induced pluripotent stem cell (iPSC)-derived model of the blood-brain barrier and establish the suitability of an iPSC-derived neuron model of the disease to facilitate compound screening.
Fri Oct 09 00:00:00 EDT 2020
Multiplex coherent anti-Stokes Raman scattering microspectroscopy detection of lipid droplets in cancer cells expressing TrkB.
Scientific reports
Guerenne-Del Ben T,Couderc V,Duponchel L,Sol V,Leproux P,Petit JM
Wed Oct 07 00:00:00 EDT 2020
Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia.
STAR protocols
Ryan SK,Jordan-Sciutto KL,Anderson SA
Fri Dec 18 00:00:00 EST 2020
Early life experiences selectively mature learning and memory abilities.
Nature communications
Bessières B,Travaglia A,Mowery TM,Zhang X,Alberini CM
Fri Jan 31 00:00:00 EST 2020
Recapitulation of Neural Crest Specification and EMT via Induction from Neural Plate Border-like Cells.
Stem cell reports
Kobayashi GS,Musso CM,Moreira DP,Pontillo-Guimarães G,Hsia GSP,Caires-Júnior LC,Goulart E,Passos-Bueno MR
Tue Sep 08 00:00:00 EDT 2020
Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD.
Molecular neurodegeneration
Andrade NS,Ramic M,Esanov R,Liu W,Rybin MJ,Gaidosh G,Abdallah A,Del'Olio S,Huff TC,Chee NT,Anatha S,Gendron TF,Wahlestedt C,Zhang Y,Benatar M,Mueller C,Zeier Z
450-02 was used in Cell Culture to study the efficiency of specific repair pathways using DNA double strand break (DSB) repair assays.
Mon Feb 24 00:00:00 EST 2020
New insights on the modeling of the molecular mechanisms underlying neural maps alignment in the midbrain.
eLife
Savier EL,Dunbar J,Cheung K,Reber M
450-02 was used in Cell Culture to predict and validate in vivo the visual mapping defects in a well-characterized mouse model to confirm the basic mechanisms of visual map organization.
Wed Sep 30 00:00:00 EDT 2020
The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells.
Communications biology
Fatima A,Irmak D,Noormohammadi A,Rinschen MM,Das A,Leidecker O,Schindler C,Sánchez-Gaya V,Wagle P,Pokrzywa W,Hoppe T,Rada-Iglesias A,Vilchez D
Mon May 25 00:00:00 EDT 2020
Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing.
Cell reports
Knupp A,Mishra S,Martinez R,Braggin JE,Szabo M,Kinoshita C,Hailey DW,Small SA,Jayadev S,Young JE
450-02 was used in Cell Culture to validate defects in neuronal endosomal trafficking following the depletion of the SORL1.
Tue Jun 02 00:00:00 EDT 2020
Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells.
Nature communications
Panagiotakopoulou V,Ivanyuk D,De Cicco S,Haq W,Arsić A,Yu C,Messelodi D,Oldrati M,Schöndorf DC,Perez MJ,Cassatella RP,Jakobi M,Schneiderhan-Marra N,Gasser T,Nikić-Spiegel I,Deleidi M
Wed Oct 14 00:00:00 EDT 2020
Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection.
Stem cell reports
Ryan SK,Gonzalez MV,Garifallou JP,Bennett FC,Williams KS,Sotuyo NP,Mironets E,Cook K,Hakonarson H,Anderson SA,Jordan-Sciutto KL
Tue Apr 14 00:00:00 EDT 2020
Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy.
Clinical & translational immunology
Ebert LM,Yu W,Gargett T,Toubia J,Kollis PM,Tea MN,Ebert BW,Bardy C,van den Hurk M,Bonder CS,Manavis J,Ensbey KS,Oksdath Mansilla M,Scheer KG,Perrin SL,Ormsby RJ,Poonnoose S,Koszyca B,Pitson SM,Day BW,Gomez GA,Brown MP
Sun Apr 17 00:00:00 EDT 2022
Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3'UTR binding.
Scientific reports
Garone MG,Alfano V,Salvatori B,Braccia C,Peruzzi G,Colantoni A,Bozzoni I,Armirotti A,Rosa A
Thu Jul 16 00:00:00 EDT 2020
Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang D,Liu C,Li H,Jiao J
Tue Dec 01 00:00:00 EST 2020
Identification of candidate genetic variants and altered protein expression in neural stem and mature neural cells support altered microtubule function to be an essential component in bipolar disorder.
Translational psychiatry
Truvé K,Parris TZ,Vizlin-Hodzic D,Salmela S,Berger E,Ågren H,Funa K
Mon Nov 09 00:00:00 EST 2020
Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons.
Scientific reports
Schwartzentruber A,Boschian C,Lopes FM,Myszczynska MA,New EJ,Beyrath J,Smeitink J,Ferraiuolo L,Mortiboys H
Wed Sep 23 00:00:00 EDT 2020
FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits.
Cell stem cell
Bowers M,Liang T,Gonzalez-Bohorquez D,Zocher S,Jaeger BN,Kovacs WJ,Röhrl C,Cramb KML,Winterer J,Kruse M,Dimitrieva S,Overall RW,Wegleiter T,Najmabadi H,Semenkovich CF,Kempermann G,Földy C,Jessberger S
450-02 was used in Cell Culture to investigate lipid metabolism and cognitive function in neural stem/progenitor cells and human embryonic stem cells.
Thu Jul 02 00:00:00 EDT 2020
Optimized culture of retinal ganglion cells and amacrine cells from adult mice.
PloS one
Park YH,Snook JD,Zhuang I,Shen G,Frankfort BJ
450-02 was used in Cell Culture to develop a technique to isolate retinal neurons from adult mice, which can be used to model in vivo neuronal behaviors.
Tue Jan 19 00:00:00 EST 2021
Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes.
Cell reports
Sleigh JN,Tosolini AP,Gordon D,Devoy A,Fratta P,Fisher EMC,Talbot K,Schiavo G
450-02 was used in In vivo experiments to investigate dynamics of axonal transport in amyotrophic lateral sclerosis.
Tue Mar 17 00:00:00 EDT 2020
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids.
eLife
Renner H,Grabos M,Becker KJ,Kagermeier TE,Wu J,Otto M,Peischard S,Zeuschner D,TsyTsyura Y,Disse P,Klingauf J,Leidel SA,Seebohm G,Schöler HR,Bruder JM
Tue Nov 03 00:00:00 EST 2020
Amyloid precursor protein is a restriction factor that protects against Zika virus infection in mammalian brains.
The Journal of biological chemistry
Lingel A,Lin H,Gavriel Y,Weaver E,Polepole P,Lopez V,Lei Y,Petro TM,Solomon B,Zhang C,Zhang L
Fri Dec 11 00:00:00 EST 2020
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism.
bioRxiv : the preprint server for biology
Jacob F,Pather SR,Huang WK,Wong SZH,Zhou H,Zhang F,Cubitt B,Chen CZ,Xu M,Pradhan M,Zhang DY,Zheng W,Bang AG,Song H,de A Torre JC,Ming GL
Tue Jul 28 00:00:00 EDT 2020
Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons.
Nature communications
Mazzara PG,Muggeo S,Luoni M,Massimino L,Zaghi M,Valverde PT,Brusco S,Marzi MJ,Palma C,Colasante G,Iannielli A,Paulis M,Cordiglieri C,Giannelli SG,Podini P,Gellera C,Taroni F,Nicassio F,Rasponi M,Broccoli V
Fri Aug 21 00:00:00 EDT 2020
Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice.
Nature communications
Sun J,Huang Y,Gong J,Wang J,Fan Y,Cai J,Wang Y,Qiu Y,Wei Y,Xiong C,Chen J,Wang B,Ma Y,Huang L,Chen X,Zheng S,Huang W,Ke Q,Wang T,Li X,Zhang W,Xiang AP,Li W
Thu Oct 15 00:00:00 EDT 2020
Benzothiazole amphiphiles promote RasGRF1-associated dendritic spine formation in human stem cell-derived neurons.
FEBS open bio
Cifelli JL,Berg KR,Yang J
Sun Mar 01 00:00:00 EST 2020
Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens.
Cell reports
Black JB,McCutcheon SR,Dube S,Barrera A,Klann TS,Rice GA,Adkar SS,Soderling SH,Reddy TE,Gersbach CA
Tue Dec 01 00:00:00 EST 2020
Accelerated neuronal and synaptic maturation by BrainPhys medium increases Aβ secretion and alters Aβ peptide ratios from iPSC-derived cortical neurons.
Scientific reports
Satir TM,Nazir FH,Vizlin-Hodzic D,Hardselius E,Blennow K,Wray S,Zetterberg H,Agholme L,Bergström P
Fri Jan 17 00:00:00 EST 2020
ASCL1- and DLX2-induced GABAergic neurons from hiPSC-derived NPCs.
Journal of neuroscience methods
Barretto N,Zhang H,Powell SK,Fernando MB,Zhang S,Flaherty EK,Ho SM,Slesinger PA,Duan J,Brennand KJ
450-02 was used in Cell Culture to adapt an ASCL1 and DLX2 overexpression protocol, efficiently generating hiPSC derived NPC-GABAergic neurons, for diease modeling and precision drug screening studies.
Fri Feb 14 00:00:00 EST 2020
Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing.
Scientific reports
Moses C,Hodgetts SI,Nugent F,Ben-Ary G,Park KK,Blancafort P,Harvey AR
Thu Jul 09 00:00:00 EDT 2020
Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency.
Nature communications
Ouwendijk WJD,Depledge DP,Rajbhandari L,Lenac Rovis T,Jonjic S,Breuer J,Venkatesan A,Verjans GMGM,Sadaoka T
Thu Dec 10 00:00:00 EST 2020
Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model.
eLife
Lee H,Lee HY,Lee BE,Gerovska D,Park SY,Zaehres H,Araúzo-Bravo MJ,Kim JI,Ha Y,Schöler HR,Kim JB
450-02 was used in Cell Culture to investigate the use of induced motor neurons to treat spinal cord injury.
Tue Jun 23 00:00:00 EDT 2020
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.
Nature medicine
Swarup V,Hinz FI,Rexach JE,Noguchi KI,Toyoshiba H,Oda A,Hirai K,Sarkar A,Seyfried NT,Cheng C,Haggarty SJ,Grossman M,Van Deerlin VM,Trojanowski JQ,Lah JJ,Levey AI,Kondou S,Geschwind DH
450-02 was used in Cell Culture to identify small molecules that can normalize the disease-associated modules.
Tue Jan 01 00:00:00 EST 2019
Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses.
Cell
Patzke C,Brockmann MM,Dai J,Gan KJ,Grauel MK,Fenske P,Liu Y,Acuna C,Rosenmund C,Südhof TC
Thu Oct 03 00:00:00 EDT 2019
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.
Cell
Liao YC,Fernandopulle MS,Wang G,Choi H,Hao L,Drerup CM,Patel R,Qamar S,Nixon-Abell J,Shen Y,Meadows W,Vendruscolo M,Knowles TPJ,Nelson M,Czekalska MA,Musteikyte G,Gachechiladze MA,Stephens CA,Pasolli HA,Forrest LR,St George-Hyslop P,Lippincott-Schwartz J,Ward ME
Thu Sep 19 00:00:00 EDT 2019
Reliability of human cortical organoid generation.
Nature methods
Yoon SJ,Elahi LS,Pașca AM,Marton RM,Gordon A,Revah O,Miura Y,Walczak EM,Holdgate GM,Fan HC,Huguenard JR,Geschwind DH,Pașca SP
450-02 was used in Cell Culture to find that spheroid generation was highly reliable and consistent.
Tue Jan 01 00:00:00 EST 2019
The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.
Immunity
Daniels BP,Kofman SB,Smith JR,Norris GT,Snyder AG,Kolb JP,Gao X,Locasale JW,Martinez J,Gale M,Loo YM,Oberst A
Tue Jan 15 00:00:00 EST 2019
Mediation of the Acute Stress Response by the Skeleton.
Cell metabolism
Berger JM,Singh P,Khrimian L,Morgan DA,Chowdhury S,Arteaga-Solis E,Horvath TL,Domingos AI,Marsland AL,Yadav VK,Rahmouni K,Gao XB,Karsenty G
450-02 was used in In vitro experiments to study how bone-derived signal is necessary to develop an acute stress response (ASR).
Tue Nov 05 00:00:00 EST 2019
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning.
Nature neuroscience
Sellgren CM,Gracias J,Watmuff B,Biag JD,Thanos JM,Whittredge PB,Fu T,Worringer K,Brown HE,Wang J,Kaykas A,Karmacharya R,Goold CP,Sheridan SD,Perlis RH
450-02 was used in Cell Culture to demonstrate increased synapse elimination in patient-derived neural cultures and isolated synaptosomes.
Fri Mar 01 00:00:00 EST 2019
OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome.
Cell stem cell
Xu R,Brawner AT,Li S,Liu JJ,Kim H,Xue H,Pang ZP,Kim WY,Hart RP,Liu Y,Jiang P
450-02 was used in Tissue/organ culture to conclude that altered OLIG2 expression may underlie neurodevelopmental abnormalities and cognitive defects in DS patients.
Thu Jun 06 00:00:00 EDT 2019
Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease.
The Journal of clinical investigation
Vezzoli E,Caron I,Talpo F,Besusso D,Conforti P,Battaglia E,Sogne E,Falqui A,Petricca L,Verani M,Martufi P,Caricasole A,Bresciani A,Cecchetti O,Rivetti di Val Cervo P,Sancini G,Riess O,Nguyen H,Seipold L,Saftig P,Biella G,Cattaneo E,Zuccato C
450-02 was used in Cell Culture to point to a detrimental role of hyperactive ADAM10 at the HD synapse and provide preclinical evidence of the therapeutic potential of ADAM10 inhibition in HD.
Mon May 06 00:00:00 EDT 2019
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.
Neuron
Geraghty AC,Gibson EM,Ghanem RA,Greene JJ,Ocampo A,Goldstein AK,Ni L,Yang T,Marton RM,Paşca SP,Greenberg ME,Longo FM,Monje M
Wed Jul 17 00:00:00 EDT 2019
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.
Neuron
Geraghty AC,Gibson EM,Ghanem RA,Greene JJ,Ocampo A,Goldstein AK,Ni L,Yang T,Marton RM,Paşca SP,Greenberg ME,Longo FM,Monje M
Wed Jul 17 00:00:00 EDT 2019
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.
Neuron
Sohn PD,Huang CT,Yan R,Fan L,Tracy TE,Camargo CM,Montgomery KM,Arhar T,Mok SA,Freilich R,Baik J,He M,Gong S,Roberson ED,Karch CM,Gestwicki JE,Xu K,Kosik KS,Gan L
Wed Nov 06 00:00:00 EST 2019
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.
Neuron
Fang MY,Markmiller S,Vu AQ,Javaherian A,Dowdle WE,Jolivet P,Bushway PJ,Castello NA,Baral A,Chan MY,Linsley JW,Linsley D,Mercola M,Finkbeiner S,Lecuyer E,Lewcock JW,Yeo GW
Wed Sep 04 00:00:00 EDT 2019
CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons.
Neuron
Tian R,Gachechiladze MA,Ludwig CH,Laurie MT,Hong JY,Nathaniel D,Prabhu AV,Fernandopulle MS,Patel R,Abshari M,Ward ME,Kampmann M
Wed Oct 23 00:00:00 EDT 2019
Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion.
Neuron
Matsuda T,Irie T,Katsurabayashi S,Hayashi Y,Nagai T,Hamazaki N,Adefuin AMD,Miura F,Ito T,Kimura H,Shirahige K,Takeda T,Iwasaki K,Imamura T,Nakashima K
Wed Feb 06 00:00:00 EST 2019
Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies.
Proceedings of the National Academy of Sciences of the United States of America
Xiang J,Wang ZH,Ahn EH,Liu X,Yu SP,Manfredsson FP,Sandoval IM,Ju G,Wu S,Ye K
Tue Apr 30 00:00:00 EDT 2019
A new patient-derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α-dystroglycan.
EMBO reports
Kim J,Lana B,Torelli S,Ryan D,Catapano F,Ala P,Luft C,Stevens E,Konstantinidis E,Louzada S,Fu B,Paredes-Redondo A,Chan AE,Yang F,Stemple DL,Liu P,Ketteler R,Selwood DL,Muntoni F,Lin YY
Tue Nov 05 00:00:00 EST 2019
Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS.
Glia
Dubessy AL,Mazuir E,Rappeneau Q,Ou S,Abi Ghanem C,Piquand K,Aigrot MS,Thétiot M,Desmazières A,Chan E,Fitzgibbon M,Fleming M,Krauss R,Zalc B,Ranscht B,Lubetzki C,Sol-Foulon N
Sun Dec 01 00:00:00 EST 2019
Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model.
Disease models & mechanisms
Taylor-Whiteley TR,Le Maitre CL,Duce JA,Dalton CF,Smith DP
450-02 was used in Cell Culture to demonstrate that fully differentiated human SH-SY5Y neuroblastoma cells grown in three-dimensional cell culture develop Lewy-body-like pathology upon exposure to exogenous α-synuclein species.
Tue Apr 09 00:00:00 EDT 2019
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
Human molecular genetics
Baron DM,Matheny T,Lin YC,Leszyk JD,Kenna K,Gall KV,Santos DP,Tischbein M,Funes S,Hayward LJ,Kiskinis E,Landers JE,Parker R,Shaffer SA,Bosco DA
450-02 was used in Cell Culture to suggest that Golgi to ER retrograde transport may be important under conditions of stress and is perturbed upon the expression of disease-linked proteins such as FUS.
Mon Jul 01 00:00:00 EDT 2019
Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor.
Molecular and cellular neurosciences
Saadipour K,Tiberi A,Lombardo S,Grajales E,Montroull L,Mañucat-Tan NB,LaFrancois J,Cammer M,Mathews PM,Scharfman HE,Liao FF,Friedman WJ,Zhou XF,Tesco G,Chao MV
450-02 was used in Sample Preparation (Western Blotting) to investigate the mechanisms of p75 involved in BACE1 expression.
Sun Sep 01 00:00:00 EDT 2019
Does Seipin Play a Role in Oxidative Stress Protection and Peroxisome Biogenesis? New Insights from Human Brain Autopsies.
Neuroscience
Sánchez-Iglesias S,Fernández-Liste A,Guillín-Amarelle C,Rábano A,Rodriguez-Cañete L,González-Méndez B,Fernández-Pombo A,Senra A,Araújo-Vilar D
450-02 was used in Cell Culture to determine the role of seipin in CNS, potentially providing protection against oxidative stress and modulating peroxisome biogenesis.
Tue Jan 01 00:00:00 EST 2019
Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene.
The European journal of neuroscience
Chen Y,Dolt KS,Kriek M,Baker T,Downey P,Drummond NJ,Canham MA,Natalwala A,Rosser S,Kunath T
Fri Feb 01 00:00:00 EST 2019
Chromatin Decondensation by FOXP2 Promotes Human Neuron Maturation and Expression of Neurodevelopmental Disease Genes.
Cell reports
Hickey SL,Berto S,Konopka G
450-02 was used in Cell Culture to study the mechanisms by which FOXP2 exerts regulatory control over targets during neuronal maturation.
Tue May 07 00:00:00 EDT 2019
Organoid-derived C-Kit+/SSEA4- human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents.
Nature communications
Zou T,Gao L,Zeng Y,Li Q,Li Y,Chen S,Hu X,Chen X,Fu C,Xu H,Yin ZQ
Thu Mar 14 00:00:00 EDT 2019
Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications.
Cell stem cell
Vatine GD,Barrile R,Workman MJ,Sances S,Barriga BK,Rahnama M,Barthakur S,Kasendra M,Lucchesi C,Kerns J,Wen N,Spivia WR,Chen Z,Van Eyk J,Svendsen CN
450-02 was used in Cell Culture to create a neurovascular unit that recapitulates complex BBB functions.
Thu Jun 06 00:00:00 EDT 2019
5-HTT independent effects of fluoxetine on neuroplasticity.
Scientific reports
Levy MJF,Boulle F,Emerit MB,Poilbout C,Steinbusch HWM,Van den Hove DLA,Kenis G,Lanfumey L
Fri Apr 19 00:00:00 EDT 2019
Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors.
PeerJ
Diniz CRAF,Biojone C,Joca SRL,Rantamäki T,Castrén E,Guimarães FS,Casarotto PC
450-02 was used in In vivo experiments to indicate that anandamide engages a coordinated activation of TRKB, via CB1 and TRPV1.
Fri Oct 06 00:00:00 EDT 2023
Axon-seq for in Depth Analysis of the RNA Content of Neuronal Processes.
Bio-protocol
Nijssen J,Aguila J,Hedlund E
450-02 was used in Cell Culture to evaluate Axon-seq to study both somas, dendrites and axons in isolation.
Sat Jul 20 00:00:00 EDT 2019
Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells.
Scientific reports
Gao L,Huang S,Zhang H,Hua W,Xin S,Cheng L,Guan W,Yu Y,Mao Y,Pei G
Tue Mar 05 00:00:00 EST 2019
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
Nature communications
Siddiqi FH,Menzies FM,Lopez A,Stamatakou E,Karabiyik C,Ureshino R,Ricketts T,Jimenez-Sanchez M,Esteban MA,Lai L,Tortorella MD,Luo Z,Liu H,Metzakopian E,Fernandes HJR,Bassett A,Karran E,Miller BL,Fleming A,Rubinsztein DC
Thu Apr 18 00:00:00 EDT 2019
Nystagmus-related FRMD7 gene influences the maturation and complexities of neuronal processes in human neurons.
Brain and behavior
Pu J,Dai S,Gao T,Hu J,Fang Y,Zheng R,Jin C,Zhang B
Sun Dec 01 00:00:00 EST 2019
Differentiation but not ALS mutations in FUS rewires motor neuron metabolism.
Nature communications
Vandoorne T,Veys K,Guo W,Sicart A,Vints K,Swijsen A,Moisse M,Eelen G,Gounko NV,Fumagalli L,Fazal R,Germeys C,Quaegebeur A,Fendt SM,Carmeliet P,Verfaillie C,Van Damme P,Ghesquière B,De Bock K,Van Den Bosch L
Thu Sep 12 00:00:00 EDT 2019
Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury.
Scientific reports
Shiga Y,Shiga A,Mesci P,Kwon H,Brifault C,Kim JH,Jeziorski JJ,Nasamran C,Ohtori S,Muotri AR,Gonias SL,Campana WM
Tue Dec 17 00:00:00 EST 2019
Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury.
Scientific reports
Shiga Y,Shiga A,Mesci P,Kwon H,Brifault C,Kim JH,Jeziorski JJ,Nasamran C,Ohtori S,Muotri AR,Gonias SL,Campana WM
Tue Dec 17 00:00:00 EST 2019
3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Bolognin S,Fossépré M,Qing X,Jarazo J,Ščančar J,Moreno EL,Nickels SL,Wasner K,Ouzren N,Walter J,Grünewald A,Glaab E,Salamanca L,Fleming RMT,Antony PMA,Schwamborn JC
Wed Jan 09 00:00:00 EST 2019
The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing.
The Journal of biological chemistry
Tischbein M,Baron DM,Lin YC,Gall KV,Landers JE,Fallini C,Bosco DA
Fri Jun 28 00:00:00 EDT 2019
Efficient Generation of Trunk Neural Crest and Sympathetic Neurons from Human Pluripotent Stem Cells Via a Neuromesodermal Axial Progenitor Intermediate.
Current protocols in stem cell biology
Frith TJR,Tsakiridis A
450-02 was used in Cell Culture to describe a detailed protocol for the efficient in vitro generation of trunk neural crest (NC) cells and their derivatives from human pluripotent stem cells (hPSCs).
Sat Jun 01 00:00:00 EDT 2019
Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes.
Nature neuroscience
Aydin B,Kakumanu A,Rossillo M,Moreno-Estellés M,Garipler G,Ringstad N,Flames N,Mahony S,Mazzoni EO
450-02 was used in Cell Culture to find that two main vertebrate proneural factors, Ascl1 and neurogenin 2 (Neurog2), induce different neuronal fates by binding to largely different sets of genomic sites, using direct neuronal programming of embryonic stem cells.
Sat Jun 01 00:00:00 EDT 2019
Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons.
eLife
An D,Fujiki R,Iannitelli DE,Smerdon JW,Maity S,Rose MF,Gelber A,Wanaselja EK,Yagudayeva I,Lee JY,Vogel C,Wichterle H,Engle EC,Mazzoni EO
450-02 was used in Cell Culture to show an ESC-based platform has identified a superior capacity to maintain a healthy proteome as a possible mechanism to resist ALS-induced neurodegeneration.
Mon Jun 03 00:00:00 EDT 2019
Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer's disease using patient iPSC-derived neurons.
Scientific reports
Wu PC,Fann MJ,Tran TT,Chen SC,Devina T,Cheng IH,Lien CC,Kao LS,Wang SJ,Fuh JL,Tzeng TT,Huang CY,Shiao YJ,Wong YH
Tue Dec 17 00:00:00 EST 2019
A Novel Toolkit for Characterizing the Mechanical and Electrical Properties of Engineered Neural Tissues.
Biosensors
Robinson M,Valente KP,Willerth SM
450-02 was used in Cell Culture to design and validate a set of robust and non-toxic protocols for directly evaluating the properties of engineered neural tissue.
Mon Apr 01 00:00:00 EDT 2019
Postinjury Inhibition of miR-181a Promotes Restoration of Hippocampal CA1 Neurons after Transient Forebrain Ischemia in Rats.
eNeuro
Griffiths BB,Ouyang YB,Xu L,Sun X,Giffard RG,Stary CM
450-02 was used in In vitro experiments to evaluate the use of anti-miR-181a for postinjury treatment of CA1 neuron recovery.
Thu Mar 05 00:00:00 EST 2020
Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death.
Scientific reports
Ajmone-Cat MA,Onori A,Toselli C,Stronati E,Morlando M,Bozzoni I,Monni E,Kokaia Z,Lupo G,Minghetti L,Biagioni S,Cacci E
Thu Mar 14 00:00:00 EDT 2019
Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology.
Scientific reports
Fenske P,Grauel MK,Brockmann MM,Dorrn AL,Trimbuch T,Rosenmund C
Wed Mar 20 00:00:00 EDT 2019
Automated microfluidic cell culture of stem cell derived dopaminergic neurons.
Scientific reports
Kane KIW,Moreno EL,Hachi S,Walter M,Jarazo J,Oliveira MAP,Hankemeier T,Vulto P,Schwamborn JC,Thoma M,Fleming RMT
Mon Feb 11 00:00:00 EST 2019
Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2.
The Journal of biological chemistry
Fred SM,Laukkanen L,Brunello CA,Vesa L,Göös H,Cardon I,Moliner R,Maritzen T,Varjosalo M,Casarotto PC,Castrén E
Fri Nov 29 00:00:00 EST 2019
Sex-specific transcriptional and proteomic signatures in schizophrenia.
Nature communications
Tiihonen J,Koskuvi M,Storvik M,Hyötyläinen I,Gao Y,Puttonen KA,Giniatullina R,Poguzhelskaya E,Ojansuu I,Vaurio O,Cannon TD,Lönnqvist J,Therman S,Suvisaari J,Kaprio J,Cheng L,Hill AF,Lähteenvuo M,Tohka J,Giniatullin R,Lehtonen Š,Koistinaho J
Mon Sep 02 00:00:00 EDT 2019
TAE226, a dual inhibitor of focal adhesion kinase and insulin-like growth factor-I receptor, is effective for Ewing sarcoma.
Cancer medicine
Moritake H,Saito Y,Sawa D,Sameshima N,Yamada A,Kinoshita M,Kamimura S,Konomoto T,Nunoi H
Sun Dec 01 00:00:00 EST 2019
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Nature communications
Zhao Y,Sun X,Hu D,Prosdocimo DA,Hoppel C,Jain MK,Ramachandran R,Qi X
Tue Mar 26 00:00:00 EDT 2019
Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy.
Scientific reports
Malik B,Devine H,Patani R,La Spada AR,Hanna MG,Greensmith L
Tue Mar 05 00:00:00 EST 2019
DAP5 increases axonal outgrowth of hippocampal neurons by enhancing the cap-independent translation of DSCR1.4 mRNA.
Cell death & disease
Seo JY,Jung Y,Kim DY,Ryu HG,Lee J,Kim SW,Kim KT
Fri Jan 18 00:00:00 EST 2019
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons.
Scientific reports
Calatayud C,Carola G,Fernández-Carasa I,Valtorta M,Jiménez-Delgado S,Díaz M,Soriano-Fradera J,Cappelletti G,García-Sancho J,Raya Á,Consiglio A
450-02 was used in Cell Culture to investigate induced pluripotent stem cells use in Parkinson’s.
Thu May 02 00:00:00 EDT 2019
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons.
Scientific reports
Calatayud C,Carola G,Fernández-Carasa I,Valtorta M,Jiménez-Delgado S,Díaz M,Soriano-Fradera J,Cappelletti G,García-Sancho J,Raya Á,Consiglio A
450-02 was used in Cell Culture to investigate induced pluripotent stem cells use in Parkinson’s.
Thu May 02 00:00:00 EDT 2019
Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging.
Stem cell reports
Cozzi A,Orellana DI,Santambrogio P,Rubio A,Cancellieri C,Giannelli S,Ripamonti M,Taverna S,Di Lullo G,Rovida E,Ferrari M,Forni GL,Fiorillo C,Broccoli V,Levi S
Tue Nov 12 00:00:00 EST 2019
Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome.
Nature communications
Zhu W,Zhang B,Li M,Mo F,Mi T,Wu Y,Teng Z,Zhou Q,Li W,Hu B
Mon Feb 25 00:00:00 EST 2019
Single-cell qPCR demonstrates that Repsox treatment changes cell fate from endoderm to neuroectoderm and disrupts epithelial-mesenchymal transition.
PloS one
Li Q,Huang Q
450-02 was used in Cell Culture to show that the process of epithelial-to-mesenchymal transition, which is inherent to the process of definitive endoderm differentiation, was also disrupted upon Repsox treatment. Our findings may provide a new approach to produce neural progenitors.
Wed Mar 11 00:00:00 EDT 2020
Modeling Parkinson's disease in midbrain-like organoids.
NPJ Parkinson's disease
Smits LM,Reinhardt L,Reinhardt P,Glatza M,Monzel AS,Stanslowsky N,Rosato-Siri MD,Zanon A,Antony PM,Bellmann J,Nicklas SM,Hemmer K,Qing X,Berger E,Kalmbach N,Ehrlich M,Bolognin S,Hicks AA,Wegner F,Sterneckert JL,Schwamborn JC
Wed Sep 30 00:00:00 EDT 2020
Preparation and Co-Culture of iPSC-Derived Dopaminergic Neurons and Astrocytes.
Current protocols in cell biology
de Rus Jacquet A
Sun Dec 01 00:00:00 EST 2019
Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility.
Nature communications
Won H,Huang J,Opland CK,Hartl CL,Geschwind DH
Mon Jun 03 00:00:00 EDT 2019
A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons.
Scientific reports
Sridharan B,Hubbs C,Llamosas N,Kilinc M,Singhera FU,Willems E,Piper DR,Scampavia L,Rumbaugh G,Spicer TP
Fri Jun 21 00:00:00 EDT 2019
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys.
Nature
Zhang W,Wan H,Feng G,Qu J,Wang J,Jing Y,Ren R,Liu Z,Zhang L,Chen Z,Wang S,Zhao Y,Wang Z,Yuan Y,Zhou Q,Li W,Liu GH,Hu B
Wed Aug 01 00:00:00 EDT 2018
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys.
Nature
Zhang W,Wan H,Feng G,Qu J,Wang J,Jing Y,Ren R,Liu Z,Zhang L,Chen Z,Wang S,Zhao Y,Wang Z,Yuan Y,Zhou Q,Li W,Liu GH,Hu B
Wed Aug 01 00:00:00 EDT 2018
The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis.
Cell
de la Torre-Ubieta L,Stein JL,Won H,Opland CK,Liang D,Lu D,Geschwind DH
Thu Jan 11 00:00:00 EST 2018
Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors.
Cell
Konermann S,Lotfy P,Brideau NJ,Oki J,Shokhirev MN,Hsu PD
Thu Apr 19 00:00:00 EDT 2018
Generation and post-injury integration of human spinal cord neural stem cells.
Nature methods
Kumamaru H,Kadoya K,Adler AF,Takashima Y,Graham L,Coppola G,Tuszynski MH
Sat Sep 01 00:00:00 EDT 2018
3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds.
Advanced functional materials
Joung D,Truong V,Neitzke CC,Guo SZ,Walsh PJ,Monat JR,Meng F,Park SH,Dutton JR,Parr AM,McAlpine MC
450-02 was used in Cell Culture to introduce a living platform to model spinal cord cytoarchitecture which could ultimately be used as a therapeutic for chronic spinal cord injury to regenerate axons across the lesion site.
Wed Sep 26 00:00:00 EDT 2018
The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
The Journal of clinical investigation
Wang B,Joo JH,Mount R,Teubner BJW,Krenzer A,Ward AL,Ichhaporia VP,Adams EJ,Khoriaty R,Peters ST,Pruett-Miller SM,Zakharenko SS,Ginsburg D,Kundu M
Wed Aug 01 00:00:00 EDT 2018
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
Neuron
Lin YT,Seo J,Gao F,Feldman HM,Wen HL,Penney J,Cam HP,Gjoneska E,Raja WK,Cheng J,Rueda R,Kritskiy O,Abdurrob F,Peng Z,Milo B,Yu CJ,Elmsaouri S,Dey D,Ko T,Yankner BA,Tsai LH
Wed Jun 27 00:00:00 EDT 2018
Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors.
Neuron
Blanco-Suarez E,Liu TF,Kopelevich A,Allen NJ
Wed Dec 05 00:00:00 EST 2018
Role for Wnt Signaling in Retinal Neuropil Development: Analysis via RNA-Seq and In Vivo Somatic CRISPR Mutagenesis.
Neuron
Sarin S,Zuniga-Sanchez E,Kurmangaliyev YZ,Cousins H,Patel M,Hernandez J,Zhang KX,Samuel MA,Morey M,Sanes JR,Zipursky SL
Wed Apr 04 00:00:00 EDT 2018
Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly.
Neuron
Jacko M,Weyn-Vanhentenryck SM,Smerdon JW,Yan R,Feng H,Williams DJ,Pai J,Xu K,Wichterle H,Zhang C
Wed Feb 21 00:00:00 EST 2018
Tau Kinetics in Neurons and the Human Central Nervous System.
Neuron
Sato C,Barthélemy NR,Mawuenyega KG,Patterson BW,Gordon BA,Jockel-Balsarotti J,Sullivan M,Crisp MJ,Kasten T,Kirmess KM,Kanaan NM,Yarasheski KE,Baker-Nigh A,Benzinger TLS,Miller TM,Karch CM,Bateman RJ
Wed Mar 21 00:00:00 EDT 2018
GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.
The Journal of experimental medicine
Ackerman SD,Luo R,Poitelon Y,Mogha A,Harty BL,D'Rozario M,Sanchez NE,Lakkaraju AKK,Gamble P,Li J,Qu J,MacEwan MR,Ray WZ,Aguzzi A,Feltri ML,Piao X,Monk KR
Mon Mar 05 00:00:00 EST 2018
Generation and assembly of human brain region-specific three-dimensional cultures.
Nature protocols
Sloan SA,Andersen J,Pașca AM,Birey F,Pașca SP
450-02 was used in In vitro experiments to propose a method to generate and assemble subdomain-specific forebrain spheroids, also known as brain region-specific organoids, from human pluripotent stem cells (hPSCs).
Sat Sep 01 00:00:00 EDT 2018
Generation of human brain region-specific organoids using a miniaturized spinning bioreactor.
Nature protocols
Qian X,Jacob F,Song MM,Nguyen HN,Song H,Ming GL
Thu Mar 01 00:00:00 EST 2018
MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts.
Developmental cell
Lee SW,Oh YM,Lu YL,Kim WK,Yoo AS
450-02 was used in In vitro experiments to study how miR-9/9∗-124 breaks the cell fate barrier to activate the neuronal program.
Mon Jul 02 00:00:00 EDT 2018
Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells.
Experimental & molecular medicine
Kim JY,Lee JS,Hwang HS,Lee DR,Park CY,Jung SJ,You YR,Kim DS,Kim DW
Fri Apr 13 00:00:00 EDT 2018
Influencing the Fate of Cardiac and Neural Stem Cell Differentiation Using Small Molecule Inhibitors of ALK5.
Stem cells translational medicine
Zhong Q,Laco F,Liao MC,Woo TL,Oh SKW,Chai CLL
Mon Oct 01 00:00:00 EDT 2018
Expression Pattern of the Aspartyl-tRNA Synthetase DARS in the Human Brain.
Frontiers in molecular neuroscience
Fröhlich D,Suchowerska AK,Voss C,He R,Wolvetang E,von Jonquieres G,Simons C,Fath T,Housley GD,Klugmann M
450-02 was used in Cell Culture to analyse endogenous DARS expression on the mRNA and protein level in different regions and cell types of human post mortem brain tissue.
Thu Oct 01 00:00:00 EDT 2020
Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells.
Frontiers in molecular neuroscience
van den Hurk M,Erwin JA,Yeo GW,Gage FH,Bardy C
450-02 was used in In vitro experiments to combine scRNA-seq with patch-clamping electrophysiological recording and morphological analysis of single human neurons in vitro which could be used on neurons in vitro to profile cell types and states in depth to unravel the human molecular basis of neuronal diversity and investigate the cellular mechanisms underlying brain disorders.
Wed Sep 30 00:00:00 EDT 2020
CXCR4/SDF1 signalling promotes sensory neuron clustering in vitro.
Biology open
Terheyden-Keighley D,Zhang X,Brand-Saberi B,Theiss C
450-02 was used in In vitro experiments to investigate mechanisms of dorsal root ganglia formation in development.
Wed Sep 19 00:00:00 EDT 2018
Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease.
Stem cell reports
Wang YK,Zhu WW,Wu MH,Wu YH,Liu ZX,Liang LM,Sheng C,Hao J,Wang L,Li W,Zhou Q,Hu BY
Tue Jul 10 00:00:00 EDT 2018
TNF inhibits catecholamine production from induced sympathetic neuron-like cells in rheumatoid arthritis and osteoarthritis in vitro.
Scientific reports
Herrmann M,Anders S,Straub RH,Jenei-Lanzl Z
Mon Jun 25 00:00:00 EDT 2018
A closer look at neuron interaction with track-etched microporous membranes.
Scientific reports
George JH,Nagel D,Waller S,Hill E,Parri HR,Coleman MD,Cui Z,Ye H
Fri Oct 19 00:00:00 EDT 2018
Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model.
Cell death & disease
Fan JR,Lee HT,Lee W,Lin CH,Hsu CY,Hsieh CH,Shyu WC
Tue May 01 00:00:00 EDT 2018
Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression.
Translational psychiatry
Srikanth P,Lagomarsino VN,Pearse RV,Liao M,Ghosh S,Nehme R,Seyfried N,Eggan K,Young-Pearse TL
Thu Nov 08 00:00:00 EST 2018
Intracellular amyloid beta expression leads to dysregulation of the mitogen-activated protein kinase and bone morphogenetic protein-2 signaling axis.
PloS one
Cruz E,Kumar S,Yuan L,Arikkath J,Batra SK
450-02 was used in In vitro experiments to reveal that iAβ1-42 amplification leads to significant reduction in ERK 1/2 phosphorylation and increased BMP2 dependent Smad 1/5/8 phosphorylation.
Mon Mar 19 00:00:00 EDT 2018
Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy.
Scientific reports
Gonçalves IDCG,Brecht J,Thelen MP,Rehorst WA,Peters M,Lee HJ,Motameny S,Torres-Benito L,Ebrahimi-Fakhari D,Kononenko NL,Altmüller J,Vilchez D,Sahin M,Wirth B,Kye MJ
Mon May 21 00:00:00 EDT 2018
Antagonism between the transcription factors NANOG and OTX2 specifies rostral or caudal cell fate during neural patterning transition.
The Journal of biological chemistry
Su Z,Zhang Y,Liao B,Zhong X,Chen X,Wang H,Guo Y,Shan Y,Wang L,Pan G
Fri Mar 23 00:00:00 EDT 2018
The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death.
Scientific reports
Merlo S,Spampinato SF,Beneventano M,Sortino MA
Tue May 08 00:00:00 EDT 2018
Novel engineered, membrane-localized variants of vascular endothelial growth factor (VEGF) protect retinal ganglion cells: a proof-of-concept study.
Cell death & disease
Shen J,Xiao R,Bair J,Wang F,Vandenberghe LH,Dartt D,Baranov P,Ng YSE
Wed Oct 03 00:00:00 EDT 2018
Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo.
Scientific reports
Russell OM,Fruh I,Rai PK,Marcellin D,Doll T,Reeve A,Germain M,Bastien J,Rygiel KA,Cerino R,Sailer AW,Lako M,Taylor RW,Mueller M,Lightowlers RN,Turnbull DM,Helliwell SB
Mon Jan 29 00:00:00 EST 2018
3D bio-printed scaffold-free nerve constructs with human gingiva-derived mesenchymal stem cells promote rat facial nerve regeneration.
Scientific reports
Zhang Q,Nguyen PD,Shi S,Burrell JC,Cullen DK,Le AD
Thu Apr 26 00:00:00 EDT 2018
Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP.
Translational psychiatry
Jiang S,Wen N,Li Z,Dube U,Del Aguila J,Budde J,Martinez R,Hsu S,Fernandez MV,Cairns NJ,Harari O,Cruchaga C,Karch CM
Thu Dec 13 00:00:00 EST 2018
The N-peptide-binding mode is critical to Munc18-1 function in synaptic exocytosis.
The Journal of biological chemistry
Shen C,Liu Y,Yu H,Gulbranson DR,Kogut I,Bilousova G,Zhang C,Stowell MHB,Shen J
Fri Nov 23 00:00:00 EST 2018
Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids.
Translational psychiatry
Srikanth P,Lagomarsino VN,Muratore CR,Ryu SC,He A,Taylor WM,Zhou C,Arellano M,Young-Pearse TL
Thu Apr 12 00:00:00 EDT 2018
Insights into the ubiquitin-proteasome system of human embryonic stem cells.
Scientific reports
Saez I,Koyuncu S,Gutierrez-Garcia R,Dieterich C,Vilchez D
Tue Mar 06 00:00:00 EST 2018
p27Kip1 Modulates Axonal Transport by Regulating α-Tubulin Acetyltransferase 1 Stability.
Cell reports
Morelli G,Even A,Gladwyn-Ng I,Le Bail R,Shilian M,Godin JD,Peyre E,Hassan BA,Besson A,Rigo JM,Weil M,Brône B,Nguyen L
450-02 was used in Cell Culture to study the role of p27Kip1 in the modulation of axonal transport.
Tue May 22 00:00:00 EDT 2018
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.
Nature communications
Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA
Mon Jun 04 00:00:00 EDT 2018
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.
Nature communications
Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA
Mon Jun 04 00:00:00 EDT 2018
Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells.
Scientific reports
Alshawaf AJ,Viventi S,Qiu W,D'Abaco G,Nayagam B,Erlichster M,Chana G,Everall I,Ivanusic J,Skafidas E,Dottori M
Fri Jan 12 00:00:00 EST 2018
Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids.
Cell death & disease
Zhang B,He Y,Xu Y,Mo F,Mi T,Shen QS,Li C,Li Y,Liu J,Wu Y,Chen G,Zhu W,Qin C,Hu B,Zhou G
Mon Jun 18 00:00:00 EDT 2018
Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes.
Cell death & disease
Shim MS,Kim KY,Bu JH,Nam HS,Jeong SW,Park TL,Ellisman MH,Weinreb RN,Ju WK
Mon Feb 19 00:00:00 EST 2018
Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function.
Cell reports
Hock EM,Maniecka Z,Hruska-Plochan M,Reber S,Laferrière F,Sahadevan M K S,Ederle H,Gittings L,Pelkmans L,Dupuis L,Lashley T,Ruepp MD,Dormann D,Polymenidou M
450-02 was used in In vitro experiments to study the stress-induced nucleocytoplasmic shuttling of endogenous FUS in an ex vivo mouse central nervous system model and human neural networks.
Tue Jul 24 00:00:00 EDT 2018
Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function.
Cell reports
Hock EM,Maniecka Z,Hruska-Plochan M,Reber S,Laferrière F,Sahadevan M K S,Ederle H,Gittings L,Pelkmans L,Dupuis L,Lashley T,Ruepp MD,Dormann D,Polymenidou M
450-02 was used in In vitro experiments to study the stress-induced nucleocytoplasmic shuttling of endogenous FUS in an ex vivo mouse central nervous system model and human neural networks.
Tue Jul 24 00:00:00 EDT 2018
Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function.
Cell reports
Hock EM,Maniecka Z,Hruska-Plochan M,Reber S,Laferrière F,Sahadevan M K S,Ederle H,Gittings L,Pelkmans L,Dupuis L,Lashley T,Ruepp MD,Dormann D,Polymenidou M
450-02 was used in In vitro experiments to study the stress-induced nucleocytoplasmic shuttling of endogenous FUS in an ex vivo mouse central nervous system model and human neural networks.
Tue Jul 24 00:00:00 EDT 2018
Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease.
Nature communications
Aron R,Pellegrini P,Green EW,Maddison DC,Opoku-Nsiah K,Oliveira AO,Wong JS,Daub AC,Giorgini F,Muchowski P,Finkbeiner S
Fri Sep 28 00:00:00 EDT 2018
PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance.
Nature communications
Russell L,Swanner J,Jaime-Ramirez AC,Wang Y,Sprague A,Banasavadi-Siddegowda Y,Yoo JY,Sizemore GM,Kladney R,Zhang J,Lehman NL,Ostrowski MC,Hong B,Caligiuri M,Yu J,Kaur B
Tue Nov 27 00:00:00 EST 2018
ALS-related human cortical and motor neurons survival is differentially affected by Sema3A.
Cell death & disease
Birger A,Ottolenghi M,Perez L,Reubinoff B,Behar O
Thu Feb 15 00:00:00 EST 2018
Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling.
Scientific reports
Nzou G,Wicks RT,Wicks EE,Seale SA,Sane CH,Chen A,Murphy SV,Jackson JD,Atala AJ
Wed May 09 00:00:00 EDT 2018
Chemical conversion of human lung fibroblasts into neuronal cells.
International journal of molecular medicine
Wan XY,Xu LY,Li B,Sun QH,Ji QL,Huang DD,Zhao L,Xiao YT
450-02 was used in Cell Culture to investigate whether a cocktail of small molecules can convert human lung fibroblast cells into neurons.
Thu Mar 01 00:00:00 EST 2018
Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes.
The Journal of biological chemistry
Fong LK,Yang MM,Dos Santos Chaves R,Reyna SM,Langness VF,Woodruff G,Roberts EA,Young JE,Goldstein LSB
Fri Jul 20 00:00:00 EDT 2018
A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs.
Stem cell reports
Wu M,Zhang D,Bi C,Mi T,Zhu W,Xia L,Teng Z,Hu B,Wu Y
Tue Sep 11 00:00:00 EDT 2018
High-efficiency RNA-based reprogramming of human primary fibroblasts.
Nature communications
Kogut I,McCarthy SM,Pavlova M,Astling DP,Chen X,Jakimenko A,Jones KL,Getahun A,Cambier JC,Pasmooij AMG,Jonkman MF,Roop DR,Bilousova G
Wed Feb 21 00:00:00 EST 2018
Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons.
Scientific reports
Bayó-Puxan N,Terrasso AP,Creyssels S,Simão D,Begon-Pescia C,Lavigne M,Salinas S,Bernex F,Bosch A,Kalatzis V,Levade T,Cuervo AM,Lory P,Consiglio A,Brito C,Kremer EJ
Fri Nov 09 00:00:00 EST 2018
Time units for learning involving maintenance of system-wide cFos expression in neuronal assemblies.
Nature communications
Chowdhury A,Caroni P
Mon Oct 08 00:00:00 EDT 2018
Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model.
Cell reports
Mizuno GO,Wang Y,Shi G,Wang Y,Sun J,Papadopoulos S,Broussard GJ,Unger EK,Deng W,Weick J,Bhattacharyya A,Chen CY,Yu G,Looger LL,Tian L
450-02 was used in Cell Culture to investigate HSA21 mutations on Down syndrome.
Tue Jul 10 00:00:00 EDT 2018
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis.
Nature communications
Wang H,Guo W,Mitra J,Hegde PM,Vandoorne T,Eckelmann BJ,Mitra S,Tomkinson AE,Van Den Bosch L,Hegde ML
Tue Sep 11 00:00:00 EDT 2018
hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model.
Stem cell reports
Adil MM,Gaj T,Rao AT,Kulkarni RU,Fuentes CM,Ramadoss GN,Ekman FK,Miller EW,Schaffer DV
Tue May 08 00:00:00 EDT 2018
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Nature communications
Ludtmann MHR,Angelova PR,Horrocks MH,Choi ML,Rodrigues M,Baev AY,Berezhnov AV,Yao Z,Little D,Banushi B,Al-Menhali AS,Ranasinghe RT,Whiten DR,Yapom R,Dolt KS,Devine MJ,Gissen P,Kunath T,Jaganjac M,Pavlov EV,Klenerman D,Abramov AY,Gandhi S
Tue Jun 12 00:00:00 EDT 2018
Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors.
Stem cell reports
Hwang I,Cao D,Na Y,Kim DY,Zhang T,Yao J,Oh H,Hu J,Zheng H,Yao Y,Paik J
Tue Apr 10 00:00:00 EDT 2018
Assembly of functionally integrated human forebrain spheroids.
Nature
Birey F,Andersen J,Makinson CD,Islam S,Wei W,Huber N,Fan HC,Metzler KRC,Panagiotakos G,Thom N,O'Rourke NA,Steinmetz LM,Bernstein JA,Hallmayer J,Huguenard JR,Paşca SP
Thu May 04 00:00:00 EDT 2017
Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation.
Neuron
Farhy-Tselnicker I,van Casteren ACM,Lee A,Chang VT,Aricescu AR,Allen NJ
Wed Oct 11 00:00:00 EDT 2017
Mutant Huntingtin Disrupts the Nuclear Pore Complex.
Neuron
Grima JC,Daigle JG,Arbez N,Cunningham KC,Zhang K,Ochaba J,Geater C,Morozko E,Stocksdale J,Glatzer JC,Pham JT,Ahmed I,Peng Q,Wadhwa H,Pletnikova O,Troncoso JC,Duan W,Snyder SH,Ranum LPW,Thompson LM,Lloyd TE,Ross CA,Rothstein JD
Wed Apr 05 00:00:00 EDT 2017
Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.
Neuron
Welsbie DS,Mitchell KL,Jaskula-Ranga V,Sluch VM,Yang Z,Kim J,Buehler E,Patel A,Martin SE,Zhang PW,Ge Y,Duan Y,Fuller J,Kim BJ,Hamed E,Chamling X,Lei L,Fraser IDC,Ronai ZA,Berlinicke CA,Zack DJ
Wed Jun 21 00:00:00 EDT 2017
Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
Neuron
Sloan SA,Darmanis S,Huber N,Khan TA,Birey F,Caneda C,Reimer R,Quake SR,Barres BA,Paşca SP
Wed Aug 16 00:00:00 EDT 2017
Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration.
Neuron
Pease-Raissi SE,Pazyra-Murphy MF,Li Y,Wachter F,Fukuda Y,Fenstermacher SJ,Barclay LA,Bird GH,Walensky LD,Segal RA
Wed Oct 11 00:00:00 EDT 2017
Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation.
The Journal of experimental medicine
Peng T,Chanthaphavong RS,Sun S,Trigilio JA,Phasouk K,Jin L,Layton ED,Li AZ,Correnti CE,De van der Schueren W,Vazquez J,O'Day DR,Glass IA,Knipe DM,Wald A,Corey L,Zhu J
Mon Aug 07 00:00:00 EDT 2017
Pluripotent Nontumorigenic Adipose Tissue-Derived Muse Cells have Immunomodulatory Capacity Mediated by Transforming Growth Factor-β1.
Stem cells translational medicine
Gimeno ML,Fuertes F,Barcala Tabarrozzi AE,Attorressi AI,Cucchiani R,Corrales L,Oliveira TC,Sogayar MC,Labriola L,Dewey RA,Perone MJ
Sun Jan 01 00:00:00 EST 2017
Schwann Cells in the Ventral Dermis Do Not Derive from Myf5-Expressing Precursors.
Stem cell reports
Iribar H,Pérez-López V,Etxaniz U,Gutiérrez-Rivera A,Izeta A
Tue Nov 14 00:00:00 EST 2017
Brain-derived neurotrophic factor promotes human granulosa-like tumor cell steroidogenesis and proliferation by activating the FSH receptor-mediated signaling pathway.
Scientific reports
Xie M,Li M,Zhou J,Ding X,Shao Y,Jing J,Liu Y,Yao B
Wed Mar 15 00:00:00 EDT 2017
Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells.
eLife
Sternfeld MJ,Hinckley CA,Moore NJ,Pankratz MT,Hilde KL,Driscoll SP,Hayashi M,Amin ND,Bonanomi D,Gifford WD,Sharma K,Goulding M,Pfaff SL
450-02 was used in Cell Culture to investigate excitatory and inhibitory spinal neuron circuits.
Tue Feb 14 00:00:00 EST 2017
Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport.
EBioMedicine
Ruderisch N,Schlatter D,Kuglstatter A,Guba W,Huber S,Cusulin C,Benz J,Rufer AC,Hoernschemeyer J,Schweitzer C,Bülau T,Gärtner A,Hoffmann E,Niewoehner J,Patsch C,Baumann K,Loetscher H,Kitas E,Freskgård PO
450-02 was used in Cell Culture to demonstrate that the Brain Shuttle is essential for BACE1 peptide inhibitors to be efficacious in the brain and active-exosite design of BACE1 peptide inhibitors may be of therapeutic relevance.
Sun Oct 01 00:00:00 EDT 2017
PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.
Stem cell reports
Oksanen M,Petersen AJ,Naumenko N,Puttonen K,Lehtonen Š,Gubert Olivé M,Shakirzyanova A,Leskelä S,Sarajärvi T,Viitanen M,Rinne JO,Hiltunen M,Haapasalo A,Giniatullin R,Tavi P,Zhang SC,Kanninen KM,Hämäläinen RH,Koistinaho J
Tue Dec 12 00:00:00 EST 2017
Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells.
Nature communications
Mazzara PG,Massimino L,Pellegatta M,Ronchi G,Ricca A,Iannielli A,Giannelli SG,Cursi M,Cancellieri C,Sessa A,Del Carro U,Quattrini A,Geuna S,Gritti A,Taveggia C,Broccoli V
Tue Feb 07 00:00:00 EST 2017
Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.
Stem cell reports
Wang C,Ward ME,Chen R,Liu K,Tracy TE,Chen X,Xie M,Sohn PD,Ludwig C,Meyer-Franke A,Karch CM,Ding S,Gan L
Tue Oct 10 00:00:00 EDT 2017
A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells.
Nature communications
Ju Lee H,Bartsch D,Xiao C,Guerrero S,Ahuja G,Schindler C,Moresco JJ,Yates JR,Gebauer F,Bazzi H,Dieterich C,Kurian L,Vilchez D
Mon Nov 13 00:00:00 EST 2017
Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.
Stem cell reports
Muratore CR,Zhou C,Liao M,Fernandez MA,Taylor WM,Lagomarsino VN,Pearse RV,Rice HC,Negri JM,He A,Srikanth P,Callahan DG,Shin T,Zhou M,Bennett DA,Noggle S,Love JC,Selkoe DJ,Young-Pearse TL
Tue Dec 12 00:00:00 EST 2017
The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor.
The Journal of biological chemistry
Saadipour K,MacLean M,Pirkle S,Ali S,Lopez-Redondo ML,Stokes DL,Chao MV
Fri Oct 06 00:00:00 EDT 2017
Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains.
Nature communications
Hoffman GE,Hartley BJ,Flaherty E,Ladran I,Gochman P,Ruderfer DM,Stahl EA,Rapoport J,Sklar P,Brennand KJ
Wed Dec 20 00:00:00 EST 2017
HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients.
Nature communications
Guo W,Naujock M,Fumagalli L,Vandoorne T,Baatsen P,Boon R,Ordovás L,Patel A,Welters M,Vanwelden T,Geens N,Tricot T,Benoy V,Steyaert J,Lefebvre-Omar C,Boesmans W,Jarpe M,Sterneckert J,Wegner F,Petri S,Bohl D,Vanden Berghe P,Robberecht W,Van Damme P,Verfaillie C,Van Den Bosch L
Wed Oct 11 00:00:00 EDT 2017
LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair.
eLife
Lin JP,Mironova YA,Shrager P,Giger RJ
450-02 was used in Cell Culture to reveal a novel role for low-density lipoprotein receptor-related protein-1 in peroxisome biogenesis, lipid homeostasis, and oligodendrocyte progenitor cell differentiation during white matter development and repair.
Mon Dec 18 00:00:00 EST 2017
On-demand optogenetic activation of human stem-cell-derived neurons.
Scientific reports
Klapper SD,Sauter EJ,Swiersy A,Hyman MAE,Bamann C,Bamberg E,Busskamp V
Tue Oct 31 00:00:00 EDT 2017
On-demand optogenetic activation of human stem-cell-derived neurons.
Scientific reports
Klapper SD,Sauter EJ,Swiersy A,Hyman MAE,Bamann C,Bamberg E,Busskamp V
Tue Oct 31 00:00:00 EDT 2017
Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells.
Stem cell reports
Monzel AS,Smits LM,Hemmer K,Hachi S,Moreno EL,van Wuellen T,Jarazo J,Walter J,Brüggemann I,Boussaad I,Berger E,Fleming RMT,Bolognin S,Schwamborn JC
Tue May 09 00:00:00 EDT 2017
Expression profiles and function analysis of microRNAs in postovulatory aging mouse oocytes.
Aging
Wang TY,Zhang J,Zhu J,Lian HY,Yuan HJ,Gao M,Luo MJ,Tan JH
450-02 was used in Cell Culture to investigate microRNA profiles of ageing mice.
Sat Apr 01 00:00:00 EDT 2017
Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome.
Scientific reports
Parrini M,Ghezzi D,Deidda G,Medrihan L,Castroflorio E,Alberti M,Baldelli P,Cancedda L,Contestabile A
Mon Dec 04 00:00:00 EST 2017
Characteristic analyses of a neural differentiation model from iPSC-derived neuron according to morphology, physiology, and global gene expression pattern.
Scientific reports
Kang S,Chen X,Gong S,Yu P,Yau S,Su Z,Zhou L,Yu J,Pan G,Shi L
Mon Sep 25 00:00:00 EDT 2017
Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease.
Cell death and differentiation
Tao CC,Hsu WL,Ma YL,Cheng SJ,Lee EH
450-02 was used in In vivo experiments to study the endogenous defense mechanism that is activated on Aβ insult to reveal an important role of HDAC1 SUMOylation as a naturally occurring defense mechanism protecting against Aβ toxicity and provide an alternative therapeutic strategy against Alzheimer's disease (AD).
Sat Apr 01 00:00:00 EDT 2017
Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening.
Cell reports
He ZQ,Xia BL,Wang YK,Li J,Feng GH,Zhang LL,Li YH,Wan HF,Li TD,Xu K,Yuan XW,Li YF,Zhang XX,Zhang Y,Wang L,Li W,Zhou Q
450-02 was used in Cell Culture to demonstrate that the spontaneous diploidisation of haploid embryonic stem cells happens in metaphase due to mitotic slippage.
Tue Aug 29 00:00:00 EDT 2017
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.
Stem cell reports
Tripathi P,Rodriguez-Muela N,Klim JR,de Boer AS,Agrawal S,Sandoe J,Lopes CS,Ogliari KS,Williams LA,Shear M,Rubin LL,Eggan K,Zhou Q
Tue Aug 08 00:00:00 EDT 2017
GC/MS-based Analysis of Volatile Metabolic Profile Along in vitro Differentiation of Human Induced Pluripotent Stem Cells.
Bio-protocol
Capuano R,Talarico RV,Spitalieri P,Paolesse R,Novelli G,Sangiuolo F,Di Natale C
450-02 was used in Cell Culture to provide a protocol for volatile organic compounds (VOCs) analysis from human induced pluripotent stem cells (hiPSCs).
Tue Dec 05 00:00:00 EST 2017
Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons.
Stem cell reports
Emperador Melero J,Nadadhur AG,Schut D,Weering JV,Heine VM,Toonen RF,Verhage M
Tue Mar 14 00:00:00 EDT 2017
A missense MT-ND5 mutation in differentiated Parkinson Disease cytoplasmic hybrid induces ROS-dependent DNA Damage Response amplified by DROSHA.
Scientific reports
Pignataro D,Francia S,Zanetta F,Brenna G,Brandini S,Olivieri A,Torroni A,Biamonti G,Montecucco A
Fri Aug 25 00:00:00 EDT 2017
Two approaches reveal a new paradigm of 'switchable or genetics-influenced allele-specific DNA methylation' with potential in human disease.
Cell discovery
Martos SN,Li T,Ramos RB,Lou D,Dai H,Xu JC,Gao G,Gao Y,Wang Q,An C,Zhang X,Jia Y,Dawson VL,Dawson TM,Ji H,Wang Z
Tue Sep 29 00:00:00 EDT 2020
Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination.
Neuron
Redmond SA,Mei F,Eshed-Eisenbach Y,Osso LA,Leshkowitz D,Shen YA,Kay JN,Aurrand-Lions M,Lyons DA,Peles E,Chan JR
Wed Aug 17 00:00:00 EDT 2016
Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination.
Neuron
Redmond SA,Mei F,Eshed-Eisenbach Y,Osso LA,Leshkowitz D,Shen YA,Kay JN,Aurrand-Lions M,Lyons DA,Peles E,Chan JR
Wed Aug 17 00:00:00 EDT 2016
Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation.
The Journal of experimental medicine
Patzke C,Acuna C,Giam LR,Wernig M,Südhof TC
Mon Apr 04 00:00:00 EDT 2016
Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.
Proceedings of the National Academy of Sciences of the United States of America
He J,Zhou R,Wu Z,Carrasco MA,Kurshan PT,Farley JE,Simon DJ,Wang G,Han B,Hao J,Heller E,Freeman MR,Shen K,Maniatis T,Tessier-Lavigne M,Zhuang X
Tue May 24 00:00:00 EDT 2016
Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos.
Proceedings of the National Academy of Sciences of the United States of America
Cohen MA,Wert KJ,Goldmann J,Markoulaki S,Buganim Y,Fu D,Jaenisch R
Tue Feb 09 00:00:00 EST 2016
MicroRNA-145 Regulates Neural Stem Cell Differentiation Through the Sox2-Lin28/let-7 Signaling Pathway.
Stem cells (Dayton, Ohio)
Morgado AL,Rodrigues CM,Solá S
Sun May 01 00:00:00 EDT 2016
Generation of highly enriched V2a interneurons from mouse embryonic stem cells.
Experimental neurology
Iyer NR,Huettner JE,Butts JC,Brown CR,Sakiyama-Elbert SE
450-02 was used in Cell Culture to provide a unique tool to begin studying V2a INs in isolation or for use in in vitro models of spinal microcircuits.
Tue Mar 01 00:00:00 EST 2016
The Adaptor Protein Rai/ShcC Promotes Astrocyte-Dependent Inflammation during Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Ulivieri C,Savino MT,Luccarini I,Fanigliulo E,Aldinucci A,Bonechi E,Benagiano M,Ortensi B,Pelicci G,D'Elios MM,Ballerini C,Baldari CT
Fri Jul 15 00:00:00 EDT 2016
Organ of Corti explants direct tonotopically graded morphology of spiral ganglion neurons in vitro.
The Journal of comparative neurology
Smith FL,Davis RL
450-02 was used in Cell Culture to study the interplay between different regulators of neuronal morphology using cocultured neuron explants with peripheral target tissues removed from distinct cochlear locations.
Mon Aug 01 00:00:00 EDT 2016
In vivo imaging of axonal transport in murine motor and sensory neurons.
Journal of neuroscience methods
Gibbs KL,Kalmar B,Sleigh JN,Greensmith L,Schiavo G
450-02 was used in In vivo experiments to develop visualisation and quantification of axonal transport for neurological disease understanding and treatment development.
Fri Jan 15 00:00:00 EST 2016
TGFβ signaling regulates the choice between pluripotent and neural fates during reprogramming of human urine derived cells.
Scientific reports
Wang L,Li X,Huang W,Zhou T,Wang H,Lin A,Hutchins AP,Su Z,Chen Q,Pei D,Pan G
Thu Mar 03 00:00:00 EST 2016
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.
Nature communications
Guo X,Sun X,Hu D,Wang YJ,Fujioka H,Vyas R,Chakrapani S,Joshi AU,Luo Y,Mochly-Rosen D,Qi X
Fri Aug 26 00:00:00 EDT 2016
Firing frequency and entrainment maintained in primary auditory neurons in the presence of combined BDNF and NT3.
Scientific reports
Wright T,Gillespie LN,O'Leary SJ,Needham K
Thu Jun 23 00:00:00 EDT 2016
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.
Nature communications
Kapeli K,Pratt GA,Vu AQ,Hutt KR,Martinez FJ,Sundararaman B,Batra R,Freese P,Lambert NJ,Huelga SC,Chun SJ,Liang TY,Chang J,Donohue JP,Shiue L,Zhang J,Zhu H,Cambi F,Kasarskis E,Hoon S,Ares M,Burge CB,Ravits J,Rigo F,Yeo GW
Tue Jul 05 00:00:00 EDT 2016
MHC-class-II are expressed in a subpopulation of human neural stem cells in vitro in an IFNγ-independent fashion and during development.
Scientific reports
Vagaska B,New SE,Alvarez-Gonzalez C,D'Acquisto F,Gomez SG,Bulstrode NW,Madrigal A,Ferretti P
Fri Apr 15 00:00:00 EDT 2016
BDNF contributes to IBS-like colonic hypersensitivity via activating the enteroglia-nerve unit.
Scientific reports
Wang P,Du C,Chen FX,Li CQ,Yu YB,Han T,Akhtar S,Zuo XL,Tan XD,Li YQ
Wed Feb 03 00:00:00 EST 2016
5-HT2 receptors mediate functional modulation of GABAa receptors and inhibitory synaptic transmissions in human iPS-derived neurons.
Scientific reports
Wang H,Hu L,Liu C,Su Z,Wang L,Pan G,Guo Y,He J
Wed Feb 03 00:00:00 EST 2016
Fyn Kinase regulates GluN2B subunit-dominant NMDA receptors in human induced pluripotent stem cell-derived neurons.
Scientific reports
Zhang WB,Ross PJ,Tu Y,Wang Y,Beggs S,Sengar AS,Ellis J,Salter MW
Mon Apr 04 00:00:00 EDT 2016
Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming.
Scientific reports
Rubio A,Luoni M,Giannelli SG,Radice I,Iannielli A,Cancellieri C,Di Berardino C,Regalia G,Lazzari G,Menegon A,Taverna S,Broccoli V
Fri Nov 18 00:00:00 EST 2016
Predegenerated Schwann cells--a novel prospect for cell therapy for glaucoma: neuroprotection, neuroregeneration and neuroplasticity.
Scientific reports
Smedowski A,Liu X,Pietrucha-Dutczak M,Matuszek I,Varjosalo M,Lewin-Kowalik J
Fri Apr 01 00:00:00 EDT 2016
BMS-708163 and Nilotinib restore synaptic dysfunction in human embryonic stem cell-derived Alzheimer's disease models.
Scientific reports
Nishioka H,Tooi N,Isobe T,Nakatsuji N,Aiba K
Mon Sep 19 00:00:00 EDT 2016
The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132.
Scientific reports
Remenyi J,Bajan S,Fuller-Pace FV,Arthur JS,Hutvagner G
Mon Mar 07 00:00:00 EST 2016
α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses.
Scientific reports
Sugeno N,Jäckel S,Voigt A,Wassouf Z,Schulze-Hentrich J,Kahle PJ
Thu Nov 03 00:00:00 EDT 2016
Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds.
Nature communications
Carlson AL,Bennett NK,Francis NL,Halikere A,Clarke S,Moore JC,Hart RP,Paradiso K,Wernig M,Kohn J,Pang ZP,Moghe PV
Thu Mar 17 00:00:00 EDT 2016
Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds.
Nature communications
Carlson AL,Bennett NK,Francis NL,Halikere A,Clarke S,Moore JC,Hart RP,Paradiso K,Wernig M,Kohn J,Pang ZP,Moghe PV
Thu Mar 17 00:00:00 EDT 2016
FolR1: a novel cell surface marker for isolating midbrain dopamine neural progenitors and nascent dopamine neurons.
Scientific reports
Gennet N,Tamburini C,Nan X,Li M
Thu Sep 01 00:00:00 EDT 2016
Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS.
Scientific reports
Allodi I,Comley L,Nichterwitz S,Nizzardo M,Simone C,Benitez JA,Cao M,Corti S,Hedlund E
Mon May 16 00:00:00 EDT 2016
Transplanted neurons integrate into adult retinas and respond to light.
Nature communications
Venugopalan P,Wang Y,Nguyen T,Huang A,Muller KJ,Goldberg JL
Thu Feb 04 00:00:00 EST 2016
Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan.
Nature communications
Noormohammadi A,Khodakarami A,Gutierrez-Garcia R,Lee HJ,Koyuncu S,König T,Schindler C,Saez I,Fatima A,Dieterich C,Vilchez D
Mon Nov 28 00:00:00 EST 2016
Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells.
Scientific reports
Rhim JH,Luo X,Gao D,Xu X,Zhou T,Li F,Wang P,Wong ST,Xia X
Mon May 23 00:00:00 EDT 2016
Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration.
Scientific reports
Shim MS,Takihara Y,Kim KY,Iwata T,Yue BY,Inatani M,Weinreb RN,Perkins GA,Ju WK
Thu Sep 22 00:00:00 EDT 2016
Morpholino-mediated SOD1 reduction ameliorates an amyotrophic lateral sclerosis disease phenotype.
Scientific reports
Nizzardo M,Simone C,Rizzo F,Ulzi G,Ramirez A,Rizzuti M,Bordoni A,Bucchia M,Gatti S,Bresolin N,Comi GP,Corti S
Tue Feb 16 00:00:00 EST 2016
Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
Scientific reports
Borgs L,Peyre E,Alix P,Hanon K,Grobarczyk B,Godin JD,Purnelle A,Krusy N,Maquet P,Lefebvre P,Seutin V,Malgrange B,Nguyen L
Mon Sep 19 00:00:00 EDT 2016
BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice.
Nature neuroscience
Korb E,Herre M,Zucker-Scharff I,Darnell RB,Allis CD
450-02 was used in Cell Culture to investigate interactions between neuron activation and histone modification.
Thu Oct 01 00:00:00 EDT 2015
Analysis of conditional heterozygous STXBP1 mutations in human neurons.
The Journal of clinical investigation
Patzke C,Han Y,Covy J,Yi F,Maxeiner S,Wernig M,Südhof TC
Tue Sep 01 00:00:00 EDT 2015
Analysis of conditional heterozygous STXBP1 mutations in human neurons.
The Journal of clinical investigation
Patzke C,Han Y,Covy J,Yi F,Maxeiner S,Wernig M,Südhof TC
Tue Sep 01 00:00:00 EDT 2015
Excision of Expanded GAA Repeats Alleviates the Molecular Phenotype of Friedreich's Ataxia.
Molecular therapy : the journal of the American Society of Gene Therapy
Li Y,Polak U,Bhalla AD,Rozwadowska N,Butler JS,Lynch DR,Dent SYR,Napierala M
450-02 was used in Cell Culture to investigate GAA repeats in Friedrich’s ataxia.
Mon Jun 01 00:00:00 EDT 2015
Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus.
Proceedings of the National Academy of Sciences of the United States of America
Prieto GA,Snigdha S,Baglietto-Vargas D,Smith ED,Berchtold NC,Tong L,Ajami D,LaFerla FM,Rebek J,Cotman CW
Tue Sep 08 00:00:00 EDT 2015
Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro.
Proceedings of the National Academy of Sciences of the United States of America
Bardy C,van den Hurk M,Eames T,Marchand C,Hernandez RV,Kellogg M,Gorris M,Galet B,Palomares V,Brown J,Bang AG,Mertens J,Böhnke L,Boyer L,Simon S,Gage FH
Tue May 19 00:00:00 EDT 2015
BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation.
The Journal of cell biology
Fulgenzi G,Tomassoni-Ardori F,Babini L,Becker J,Barrick C,Puverel S,Tessarollo L
Mon Sep 14 00:00:00 EDT 2015
Notch signaling regulates motor neuron differentiation of human embryonic stem cells.
Stem cells (Dayton, Ohio)
Ben-Shushan E,Feldman E,Reubinoff BE
Sun Feb 01 00:00:00 EST 2015
PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype.
Nature communications
Duan S,Yuan G,Liu X,Ren R,Li J,Zhang W,Wu J,Xu X,Fu L,Li Y,Yang J,Zhang W,Bai R,Yi F,Suzuki K,Gao H,Esteban CR,Zhang C,Izpisua Belmonte JC,Chen Z,Wang X,Jiang T,Qu J,Tang F,Liu GH
Thu Dec 03 00:00:00 EST 2015
Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.
Scientific reports
Palm T,Bolognin S,Meiser J,Nickels S,Träger C,Meilenbrock RL,Brockhaus J,Schreitmüller M,Missler M,Schwamborn JC
Fri Nov 06 00:00:00 EST 2015
Synaptic synthesis, dephosphorylation, and degradation: a novel paradigm for an activity-dependent neuronal control of CDKL5.
The Journal of biological chemistry
La Montanara P,Rusconi L,Locarno A,Forti L,Barbiero I,Tramarin M,Chandola C,Kilstrup-Nielsen C,Landsberger N
450-02 was used in Sample Preparation (Western Blotting) to study how at all stages of development, neuronal depolarization induces a rapid increase in CDKL5 levels which is mostly mediated by extrasomatic synthesis.
Fri Feb 13 00:00:00 EST 2015
HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
Human molecular genetics
Mattis VB,Tom C,Akimov S,Saeedian J,Østergaard ME,Southwell AL,Doty CN,Ornelas L,Sahabian A,Lenaeus L,Mandefro B,Sareen D,Arjomand J,Hayden MR,Ross CA,Svendsen CN
450-02 was used in Cell Culture to investigate Huntington's disease iPSC-derived from patients and controls on brain-derived neurotrophic factor.
Mon Jun 01 00:00:00 EDT 2015
A guide to generating and using hiPSC derived NPCs for the study of neurological diseases.
Journal of visualized experiments : JoVE
Topol A,Tran NN,Brennand KJ
450-02 was used in Sample Preparation to study a methos for the efficient differentiation of human induced pluripotent stem cells (hiPSCs) into neural progenitor cells (NPCs) and neurons for the study of these diseases, it is now possible to recapitulate the developmental events that occurred prior to symptom onset in patients.
Sat Feb 21 00:00:00 EST 2015
Alzheimer's disease-related amyloid-β induces synaptotoxicity in human iPS cell-derived neurons.
Cell death & disease
Nieweg K,Andreyeva A,van Stegen B,Tanriöver G,Gottmann K
Thu Apr 02 00:00:00 EDT 2015
Spinal muscular atrophy phenotype is ameliorated in human motor neurons by SMN increase via different novel RNA therapeutic approaches.
Scientific reports
Nizzardo M,Simone C,Dametti S,Salani S,Ulzi G,Pagliarani S,Rizzo F,Frattini E,Pagani F,Bresolin N,Comi G,Corti S
Tue Jun 30 00:00:00 EDT 2015
The Specification and Maturation of Nociceptive Neurons from Human Embryonic Stem Cells.
Scientific reports
Boisvert EM,Engle SJ,Hallowell SE,Liu P,Wang ZW,Li XJ
Thu Nov 19 00:00:00 EST 2015
Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line.
Scientific reports
Sluch VM,Davis CH,Ranganathan V,Kerr JM,Krick K,Martin R,Berlinicke CA,Marsh-Armstrong N,Diamond JS,Mao HQ,Zack DJ
Fri Nov 13 00:00:00 EST 2015
Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion.
Scientific reports
Tian C,Li Y,Huang Y,Wang Y,Chen D,Liu J,Deng X,Sun L,Anderson K,Qi X,Li Y,Lee Mosley R,Chen X,Huang J,Zheng JC
Thu Jul 30 00:00:00 EDT 2015
Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells.
Nature communications
Adams KL,Rousso DL,Umbach JA,Novitch BG
Tue Apr 14 00:00:00 EDT 2015
Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells.
Nature communications
Adams KL,Rousso DL,Umbach JA,Novitch BG
Tue Apr 14 00:00:00 EDT 2015
Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature.
Scientific reports
Ng TK,Yung JS,Choy KW,Cao D,Leung CK,Cheung HS,Pang CP
Mon Nov 09 00:00:00 EST 2015
Deterministic HOX patterning in human pluripotent stem cell-derived neuroectoderm.
Stem cell reports
Lippmann ES,Williams CE,Ruhl DA,Estevez-Silva MC,Chapman ER,Coon JJ,Ashton RS
Tue Apr 14 00:00:00 EDT 2015
EphB3 receptors function as dependence receptors to mediate oligodendrocyte cell death following contusive spinal cord injury.
Cell death & disease
Tsenkina Y,Ricard J,Runko E,Quiala-Acosta MM,Mier J,Liebl DJ
Thu Oct 15 00:00:00 EDT 2015
Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons.
Nature communications
Jiang H,Xu Z,Zhong P,Ren Y,Liang G,Schilling HA,Hu Z,Zhang Y,Wang X,Chen S,Yan Z,Feng J
Mon Dec 07 00:00:00 EST 2015
Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells.
The Journal of biological chemistry
Lawn S,Krishna N,Pisklakova A,Qu X,Fenstermacher DA,Fournier M,Vrionis FD,Tran N,Chan JA,Kenchappa RS,Forsyth PA
Fri Feb 06 00:00:00 EST 2015
Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Pathak MM,Nourse JL,Tran T,Hwe J,Arulmoli J,Le DT,Bernardis E,Flanagan LA,Tombola F
Tue Nov 11 00:00:00 EST 2014
Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease.
Proceedings of the National Academy of Sciences of the United States of America
Wang Y,Chakravarty P,Ranes M,Kelly G,Brooks PJ,Neilan E,Stewart A,Schiavo G,Svejstrup JQ
Tue Oct 07 00:00:00 EDT 2014
Neutralization of nerve growth factor impairs proliferation and differentiation of adult neural progenitors in the subventricular zone.
Stem cells (Dayton, Ohio)
Scardigli R,Capelli P,Vignone D,Brandi R,Ceci M,La Regina F,Piras E,Cintoli S,Berardi N,Capsoni S,Cattaneo A
Mon Sep 01 00:00:00 EDT 2014
Defined human pluripotent stem cell culture enables highly efficient neuroepithelium derivation without small molecule inhibitors.
Stem cells (Dayton, Ohio)
Lippmann ES,Estevez-Silva MC,Ashton RS
Tue Apr 01 00:00:00 EDT 2014
Generation of neuronal progenitor cells in response to tumors in the human brain.
Stem cells (Dayton, Ohio)
Macas J,Ku MC,Nern C,Xu Y,Bühler H,Remke M,Synowitz M,Franz K,Seifert V,Plate KH,Kettenmann H,Glass R,Momma S
Wed Jan 01 00:00:00 EST 2014
Efficient specification of interneurons from human pluripotent stem cells by dorsoventral and rostrocaudal modulation.
Stem cells (Dayton, Ohio)
Kim TG,Yao R,Monnell T,Cho JH,Vasudevan A,Koh A,Peeyush KT,Moon M,Datta D,Bolshakov VY,Kim KS,Chung S
Tue Jul 01 00:00:00 EDT 2014
Analysis of Mll1 deficiency identifies neurogenic transcriptional modules and Brn4 as a factor for direct astrocyte-to-neuron reprogramming.
Neurosurgery
Potts MB,Siu JJ,Price JD,Salinas RD,Cho MJ,Ramos AD,Hahn J,Margeta M,Oldham MC,Lim DA
450-02 was used in In vitro experiments to investigate presence of healthy neuronal progenitors in mixed lineage leukaemia-1.
Wed Oct 01 00:00:00 EDT 2014
Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells.
Nature communications
Chen C,Jiang P,Xue H,Peterson SE,Tran HT,McCann AE,Parast MM,Li S,Pleasure DE,Laurent LC,Loring JF,Liu Y,Deng W
Fri Jul 18 00:00:00 EDT 2014
Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy.
The Journal of biological chemistry
Smith ED,Prieto GA,Tong L,Sears-Kraxberger I,Rice JD,Steward O,Cotman CW
Fri Jul 25 00:00:00 EDT 2014
The evolutionary young miR-1290 favors mitotic exit and differentiation of human neural progenitors through altering the cell cycle proteins.
Cell death & disease
Yelamanchili SV,Morsey B,Harrison EB,Rennard DA,Emanuel K,Thapa I,Bastola DR,Fox HS
Thu Jan 09 00:00:00 EST 2014
A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium.
Cell death & disease
Di Angelantonio S,Murana E,Cocco S,Scala F,Bertollini C,Molinari MG,Lauro C,Bregestovski P,Limatola C,Ragozzino D
Thu Oct 30 00:00:00 EDT 2014
p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.
The Journal of biological chemistry
Forsyth PA,Krishna N,Lawn S,Valadez JG,Qu X,Fenstermacher DA,Fournier M,Potthast L,Chinnaiyan P,Gibney GT,Zeinieh M,Barker PA,Carter BD,Cooper MK,Kenchappa RS
450-02 was used in In vitro experiments to evidence overexpression of the p75NTR ICD being essential for BTIC proliferation and presented as a novel potential clinical target.
Fri Mar 21 00:00:00 EDT 2014
Hu antigen R (HuR) is a positive regulator of the RNA-binding proteins TDP-43 and FUS/TLS: implications for amyotrophic lateral sclerosis.
The Journal of biological chemistry
Lu L,Zheng L,Si Y,Luo W,Dujardin G,Kwan T,Potochick NR,Thompson SR,Schneider DA,King PH
Fri Nov 14 00:00:00 EST 2014
Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.
The Journal of biological chemistry
Liu X,Obianyo O,Chan CB,Huang J,Xue S,Yang JJ,Zeng F,Goodman M,Ye K
Fri Oct 03 00:00:00 EDT 2014
Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.
The Journal of biological chemistry
Liu X,Obianyo O,Chan CB,Huang J,Xue S,Yang JJ,Zeng F,Goodman M,Ye K
Fri Oct 03 00:00:00 EDT 2014
Brain-derived neurotrophic factor (BDNF)-induced mitochondrial motility arrest and presynaptic docking contribute to BDNF-enhanced synaptic transmission.
The Journal of biological chemistry
Su B,Ji YS,Sun XL,Liu XH,Chen ZY
Fri Jan 17 00:00:00 EST 2014
Purification of dorsal root ganglion neurons from rat by immunopanning.
Cold Spring Harbor protocols
Zuchero JB
450-02 was used in Sample Preparation to propose a method to study the role of glia in the biology of dorsal root ganglion neurons (DRGs).
Fri Aug 01 00:00:00 EDT 2014
Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning.
Nature
Donato F,Rompani SB,Caroni P
Thu Dec 12 00:00:00 EST 2013
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
Cell
Xue Y,Ouyang K,Huang J,Zhou Y,Ouyang H,Li H,Wang G,Wu Q,Wei C,Bi Y,Jiang L,Cai Z,Sun H,Zhang K,Zhang Y,Chen J,Fu XD
Thu Jan 17 00:00:00 EST 2013
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
Cell
Xue Y,Ouyang K,Huang J,Zhou Y,Ouyang H,Li H,Wang G,Wu Q,Wei C,Bi Y,Jiang L,Cai Z,Sun H,Zhang K,Zhang Y,Chen J,Fu XD
Thu Jan 17 00:00:00 EST 2013
Rapid single-step induction of functional neurons from human pluripotent stem cells.
Neuron
Zhang Y,Pak C,Han Y,Ahlenius H,Zhang Z,Chanda S,Marro S,Patzke C,Acuna C,Covy J,Xu W,Yang N,Danko T,Chen L,Wernig M,Südhof TC
Wed Jun 05 00:00:00 EDT 2013
Deficits in human trisomy 21 iPSCs and neurons.
Proceedings of the National Academy of Sciences of the United States of America
Weick JP,Held DL,Bonadurer GF,Doers ME,Liu Y,Maguire C,Clark A,Knackert JA,Molinarolo K,Musser M,Yao L,Yin Y,Lu J,Zhang X,Zhang SC,Bhattacharyya A
Tue Jun 11 00:00:00 EDT 2013
TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons.
Proceedings of the National Academy of Sciences of the United States of America
Shintani Y,Kapoor A,Kaneko M,Smolenski RT,D'Acquisto F,Coppen SR,Harada-Shoji N,Lee HJ,Thiemermann C,Takashima S,Yashiro K,Suzuki K
Tue Mar 26 00:00:00 EDT 2013
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
Proceedings of the National Academy of Sciences of the United States of America
Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA
Tue Mar 19 00:00:00 EDT 2013
Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons.
Stem cells (Dayton, Ohio)
Sundberg M,Bogetofte H,Lawson T,Jansson J,Smith G,Astradsson A,Moore M,Osborn T,Cooper O,Spealman R,Hallett P,Isacson O
Thu Aug 01 00:00:00 EDT 2013
Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons.
Stem cells (Dayton, Ohio)
Sundberg M,Bogetofte H,Lawson T,Jansson J,Smith G,Astradsson A,Moore M,Osborn T,Cooper O,Spealman R,Hallett P,Isacson O
Thu Aug 01 00:00:00 EDT 2013
Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation.
Molecular and cellular biology
Lambert WM,Xu CF,Neubert TA,Chao MV,Garabedian MJ,Jeanneteau FD
450-02 was used in In vitro experiments to study how BDNF signaling specifies and amplifies the GR transcriptome through a coordinated GR phosphorylation-dependent detection mechanism.
Sun Sep 01 00:00:00 EDT 2013
Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation.
Molecular and cellular biology
Lambert WM,Xu CF,Neubert TA,Chao MV,Garabedian MJ,Jeanneteau FD
450-02 was used in In vitro experiments to study how BDNF signaling specifies and amplifies the GR transcriptome through a coordinated GR phosphorylation-dependent detection mechanism.
Sun Sep 01 00:00:00 EDT 2013
Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of the E3 ligase Mylip/Idol.
The Journal of biological chemistry
Do HT,Bruelle C,Tselykh T,Jalonen P,Korhonen L,Lindholm D
Fri Oct 11 00:00:00 EDT 2013
Differential role of PTEN phosphatase in chemotactic growth cone guidance.
The Journal of biological chemistry
Henle SJ,Carlstrom LP,Cheever TR,Henley JR
Fri Jul 19 00:00:00 EDT 2013
Purification of oligodendrocyte precursor cells from rat cortices by immunopanning.
Cold Spring Harbor protocols
Dugas JC,Emery B
450-02 was used in Cell Culture to demonstrate how to purify oligodendrocyte precursor cells (OPCs) from postnatal rodent brains.
Thu Aug 01 00:00:00 EDT 2013
Brain-derived neurotrophic factor promotes vasculature-associated migration of neuronal precursors toward the ischemic striatum.
PloS one
Grade S,Weng YC,Snapyan M,Kriz J,Malva JO,Saghatelyan A
Fri Jul 19 00:00:00 EDT 2013
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11.
Nature
Vilchez D,Boyer L,Morantte I,Lutz M,Merkwirth C,Joyce D,Spencer B,Page L,Masliah E,Berggren WT,Gage FH,Dillin A
Thu Sep 13 00:00:00 EDT 2012
Long-distance growth and connectivity of neural stem cells after severe spinal cord injury.
Cell
Lu P,Wang Y,Graham L,McHale K,Gao M,Wu D,Brock J,Blesch A,Rosenzweig ES,Havton LA,Zheng B,Conner JM,Marsala M,Tuszynski MH
Fri Sep 14 00:00:00 EDT 2012
Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration.
The Journal of experimental medicine
Colombo E,Cordiglieri C,Melli G,Newcombe J,Krumbholz M,Parada LF,Medico E,Hohlfeld R,Meinl E,Farina C
Mon Mar 12 00:00:00 EDT 2012
Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration.
The Journal of experimental medicine
Colombo E,Cordiglieri C,Melli G,Newcombe J,Krumbholz M,Parada LF,Medico E,Hohlfeld R,Meinl E,Farina C
Mon Mar 12 00:00:00 EDT 2012
BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus.
Proceedings of the National Academy of Sciences of the United States of America
Jeanneteau FD,Lambert WM,Ismaili N,Bath KG,Lee FS,Garabedian MJ,Chao MV
Tue Jan 24 00:00:00 EST 2012
p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America
Baeza-Raja B,Li P,Le Moan N,Sachs BD,Schachtrup C,Davalos D,Vagena E,Bridges D,Kim C,Saltiel AR,Olefsky JM,Akassoglou K
Tue Apr 10 00:00:00 EDT 2012
Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc.
Proceedings of the National Academy of Sciences of the United States of America
Giorgetti A,Marchetto MC,Li M,Yu D,Fazzina R,Mu Y,Adamo A,Paramonov I,Cardoso JC,Monasterio MB,Bardy C,Cassiani-Ingoni R,Liu GH,Gage FH,Izpisua Belmonte JC
Tue Jul 31 00:00:00 EDT 2012
Serum Response Factor (SRF)-cofilin-actin signaling axis modulates mitochondrial dynamics.
Proceedings of the National Academy of Sciences of the United States of America
Beck H,Flynn K,Lindenberg KS,Schwarz H,Bradke F,Di Giovanni S,Knöll B
Tue Sep 18 00:00:00 EDT 2012
N-acetyl serotonin derivatives as potent neuroprotectants for retinas.
Proceedings of the National Academy of Sciences of the United States of America
Shen J,Ghai K,Sompol P,Liu X,Cao X,Iuvone PM,Ye K
Tue Feb 28 00:00:00 EST 2012
Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells.
Proceedings of the National Academy of Sciences of the United States of America
Abe H,Okazawa M,Nakanishi S
Tue May 29 00:00:00 EDT 2012
Increasing doublecortin expression promotes migration of human embryonic stem cell-derived neurons.
Stem cells (Dayton, Ohio)
Filipovic R,Santhosh Kumar S,Fiondella C,Loturco J
Sat Sep 01 00:00:00 EDT 2012
Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington's disease.
Experimental neurology
Sadan O,Shemesh N,Barzilay R,Dadon-Nahum M,Blumenfeld-Katzir T,Assaf Y,Yeshurun M,Djaldetti R,Cohen Y,Melamed E,Offen D
Sun Apr 01 00:00:00 EDT 2012
Pigment epithelium-derived factor released by Müller glial cells exerts neuroprotective effects on retinal ganglion cells.
Neurochemical research
Unterlauft JD,Eichler W,Kuhne K,Yang XM,Yafai Y,Wiedemann P,Reichenbach A,Claudepierre T
Sun Jul 01 00:00:00 EDT 2012
The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development.
PloS one
Di Lieto A,Rantamäki T,Vesa L,Yanpallewar S,Antila H,Lindholm J,Rios M,Tessarollo L,Castrén E
Mon Jul 23 00:00:00 EDT 2012
Differential involvement of brain-derived neurotrophic factor in reconsolidation and consolidation of conditioned taste aversion memory.
PloS one
Wang Y,Zhang TY,Xin J,Li T,Yu H,Li N,Chen ZY
Thu May 30 00:00:00 EDT 2013
miR-200c targets a NF-κB up-regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer.
PloS one
Howe EN,Cochrane DR,Cittelly DM,Richer JK
Thu May 30 00:00:00 EDT 2013
Identification of a key motif that determines the differential surface levels of RET and TrkB tyrosine kinase receptors and controls depolarization enhanced RET surface insertion.
The Journal of biological chemistry
Li XZ,Yan J,Huang SH,Zhao L,Wang J,Chen ZY
Fri Jan 13 00:00:00 EST 2012
Plasticity of Scarpa's Ganglion Neurons as a Possible Basis for Functional Restoration within Vestibular Endorgans.
Frontiers in neurology
Travo C,Gaboyard-Niay S,Chabbert C
Tue Oct 02 00:00:00 EDT 2012
Plasticity of Scarpa's Ganglion Neurons as a Possible Basis for Functional Restoration within Vestibular Endorgans.
Frontiers in neurology
Travo C,Gaboyard-Niay S,Chabbert C
Tue Oct 02 00:00:00 EDT 2012
Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors.
PloS one
Kawamura K,Chen Y,Shu Y,Cheng Y,Qiao J,Behr B,Pera RA,Hsueh AJ
Tue May 07 00:00:00 EDT 2013
LIM kinase 1 (LIMK1) interacts with tropomyosin-related kinase B (TrkB) and Mediates brain-derived neurotrophic factor (BDNF)-induced axonal elongation.
The Journal of biological chemistry
Dong Q,Ji YS,Cai C,Chen ZY
Fri Dec 07 00:00:00 EST 2012
Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism.
PloS one
Killian RL,Flippin JD,Herrera CM,Almenar-Queralt A,Goldstein LS
Mon Jun 11 00:00:00 EDT 2012
3D multicolor super-resolution imaging offers improved accuracy in neuron tracing.
PloS one
Lakadamyali M,Babcock H,Bates M,Zhuang X,Lichtman J
Mon Jun 04 00:00:00 EDT 2012
Highly pure and expandable PSA-NCAM-positive neural precursors from human ESC and iPSC-derived neural rosettes.
PloS one
Kim DS,Lee DR,Kim HS,Yoo JE,Jung SJ,Lim BY,Jang J,Kang HC,You S,Hwang DY,Leem JW,Nam TS,Cho SR,Kim DW
Fri Apr 19 00:00:00 EDT 2013
Burst analysis tool for developing neuronal networks exhibiting highly varying action potential dynamics.
Frontiers in computational neuroscience
Kapucu FE,Tanskanen JM,Mikkonen JE,Ylä-Outinen L,Narkilahti S,Hyttinen JA
Thu Aug 23 00:00:00 EDT 2012
Adult human brain neural progenitor cells (NPCs) and fibroblast-like cells have similar properties in vitro but only NPCs differentiate into neurons.
PloS one
Park TI,Monzo H,Mee EW,Bergin PS,Teoh HH,Montgomery JM,Faull RL,Curtis MA,Dragunow M
Thu Oct 11 00:00:00 EDT 2012
A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma.
The Journal of biological chemistry
Hayashi H,Eguchi Y,Fukuchi-Nakaishi Y,Takeya M,Nakagata N,Tanaka K,Vance JE,Tanihara H
Fri Jul 20 00:00:00 EDT 2012
Chondroitin sulfate proteoglycans down-regulate spine formation in cortical neurons by targeting tropomyosin-related kinase B (TrkB) protein.
The Journal of biological chemistry
Kurihara D,Yamashita T
Fri Apr 20 00:00:00 EDT 2012
Inhibition of BDNF in multiple myeloma blocks osteoclastogenesis via down-regulated stroma-derived RANKL expression both in vitro and in vivo.
PloS one
Ai LS,Sun CY,Zhang L,Zhou SC,Chu ZB,Qin Y,Wang YD,Zeng W,Yan H,Guo T,Chen L,Yang D,Hu Y
Wed Mar 20 00:00:00 EDT 2013
MicroRNA-mediated conversion of human fibroblasts to neurons.
Nature
Yoo AS,Sun AX,Li L,Shcheglovitov A,Portmann T,Li Y,Lee-Messer C,Dolmetsch RE,Tsien RW,Crabtree GR
Wed Jul 13 00:00:00 EDT 2011
Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons.
Cell
Qiang L,Fujita R,Yamashita T,Angulo S,Rhinn H,Rhee D,Doege C,Chau L,Aubry L,Vanti WB,Moreno H,Abeliovich A
Fri Aug 05 00:00:00 EDT 2011
The nerve growth factor reduces APOBEC3G synthesis and enhances HIV-1 transcription and replication in human primary macrophages.
Blood
Souza TM,Rodrigues DQ,Passaes CP,Barreto-de-Souza V,Aguiar RS,Temerozo JR,Morgado MG,Fontes CF,Araujo EG,Bou-Habib DC
Thu Mar 10 00:00:00 EST 2011
Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice.
The Journal of clinical investigation
Cazorla M,Prémont J,Mann A,Girard N,Kellendonk C,Rognan D
Sun May 01 00:00:00 EDT 2011
Development of a method for the purification and culture of rodent astrocytes.
Neuron
Foo LC,Allen NJ,Bushong EA,Ventura PB,Chung WS,Zhou L,Cahoy JD,Daneman R,Zong H,Ellisman MH,Barres BA
Thu Sep 08 00:00:00 EDT 2011
The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke.
The Journal of experimental medicine
Gomez-Sanchez JC,Delgado-Esteban M,Rodriguez-Hernandez I,Sobrino T,Perez de la Ossa N,Reverte S,Bolaños JP,Gonzalez-Sarmiento R,Castillo J,Almeida A
Mon Mar 14 00:00:00 EDT 2011
Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.
Nature protocols
Stacpoole SR,Bilican B,Webber DJ,Luzhynskaya A,He XL,Compston A,Karadottir R,Franklin RJ,Chandran S
Thu Jul 28 00:00:00 EDT 2011
The PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro.
Aging cell
Liu S,Liu S,Wang X,Zhou J,Cao Y,Wang F,Duan E
Mon Aug 01 00:00:00 EDT 2011
Development of histocompatible primate-induced pluripotent stem cells for neural transplantation.
Stem cells (Dayton, Ohio)
Deleidi M,Hargus G,Hallett P,Osborn T,Isacson O
Fri Jul 01 00:00:00 EDT 2011
Systemic delivery of bone marrow-derived mesenchymal stromal cells diminishes neuropathology in a mouse model of Krabbe's disease.
Stem cells (Dayton, Ohio)
Miranda CO,Teixeira CA,Liz MA,Sousa VF,Franquinho F,Forte G,Di Nardo P,Pinto-Do-Ó P,Sousa MM
Tue Nov 01 00:00:00 EDT 2011
Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation.
Human molecular genetics
Cheung AY,Horvath LM,Grafodatskaya D,Pasceri P,Weksberg R,Hotta A,Carrel L,Ellis J
Wed Jun 01 00:00:00 EDT 2011
Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients.
Human molecular genetics
Mitne-Neto M,Machado-Costa M,Marchetto MC,Bengtson MH,Joazeiro CA,Tsuda H,Bellen HJ,Silva HC,Oliveira AS,Lazar M,Muotri AR,Zatz M
Thu Sep 15 00:00:00 EDT 2011
A protocol for isolation and enriched monolayer cultivation of neural precursor cells from mouse dentate gyrus.
Frontiers in neuroscience
Babu H,Claasen JH,Kannan S,Rünker AE,Palmer T,Kempermann G
Thu Nov 10 00:00:00 EST 2011
Effects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia.
PloS one
Cohen-Kupiec R,Pasmanik-Chor M,Oron-Karni V,Weil M
Fri Apr 29 00:00:00 EDT 2011
Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells.
PloS one
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Wed Mar 02 00:00:00 EST 2011
Regulation of chemotropic guidance of nerve growth cones by microRNA.
Molecular brain
Han L,Wen Z,Lynn RC,Baudet ML,Holt CE,Sasaki Y,Bassell GJ,Zheng JQ
Thu Nov 03 00:00:00 EDT 2011
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.
Nature communications
Devine MJ,Ryten M,Vodicka P,Thomson AJ,Burdon T,Houlden H,Cavaleri F,Nagano M,Drummond NJ,Taanman JW,Schapira AH,Gwinn K,Hardy J,Lewis PA,Kunath T
Tue Aug 23 00:00:00 EDT 2011
3D culture of adult mouse neural stem cells within functionalized self-assembling peptide scaffolds.
International journal of nanomedicine
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Fri Nov 04 00:00:00 EDT 2011
Directed differentiation of dopamine neurons from human pluripotent stem cells.
Methods in molecular biology (Clifton, N.J.)
Ma L,Liu Y,Zhang SC
450-02 was used in Cell Culture to describe a chemically defined protocol for mDA neuron differentiation.
Thu Nov 24 00:00:00 EST 2011
Ocular neuroprotection by siRNA targeting caspase-2.
Cell death & disease
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Thu Jun 16 00:00:00 EDT 2011
Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia.
The Journal of biological chemistry
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Fri Jun 17 00:00:00 EDT 2011
Biophysical characteristics reveal neural stem cell differentiation potential.
PloS one
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Thu Jan 26 00:00:00 EST 2012
Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade.
PloS one
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Fri Dec 09 00:00:00 EST 2011
Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model.
Molecular brain
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Functional characterization of human cancer-derived TRKB mutations.
PloS one
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Bidirectional remodeling of β1-integrin adhesions during chemotropic regulation of nerve growth.
BMC biology
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Wed Nov 30 00:00:00 EST 2011
Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells.
BMC neuroscience
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L1TD1 is a marker for undifferentiated human embryonic stem cells.
PloS one
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Fri Apr 29 00:00:00 EDT 2011
The p75 receptor mediates axon growth inhibition through an association with PIR-B.
Cell death & disease
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Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension.
Nature biotechnology
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The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.
Cell
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Non-cell-autonomous factor induces the transition from excitatory to inhibitory GABA signaling in retina independent of activity.
Proceedings of the National Academy of Sciences of the United States of America
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Tue Dec 21 00:00:00 EST 2010
Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.
Proceedings of the National Academy of Sciences of the United States of America
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Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells.
PloS one
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Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice.
PloS one
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Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release.
The Journal of biological chemistry
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Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression.
The Journal of biological chemistry
Ginés S,Paoletti P,Alberch J
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The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death.
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Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells.
PLoS currents
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Spinal microglial motility is independent of neuronal activity and plasticity in adult mice.
Molecular pain
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A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome.
PloS one
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Molecular pain
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Sat Dec 18 00:00:00 EST 2010
Glycine-spacers influence functional motifs exposure and self-assembling propensity of functionalized substrates tailored for neural stem cell cultures.
Frontiers in neuroengineering
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Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells.
Molecular brain
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High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and function.
Molecular neurodegeneration
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Interferon-gamma produced by microglia and the neuropeptide PACAP have opposite effects on the viability of neural progenitor cells.
PloS one
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BMC neuroscience
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Immunopanning purification and long-term culture of human retinal ganglion cells.
Molecular vision
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High-efficient generation of induced pluripotent stem cells from human astrocytes.
PloS one
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Nature
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Differentiation of human oligodendrocytes from pluripotent stem cells.
Nature protocols
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Differentiation of spinal motor neurons from pluripotent human stem cells.
Nature protocols
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Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels.
The EMBO journal
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Proceedings of the National Academy of Sciences of the United States of America
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Tue Apr 28 00:00:00 EDT 2009
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.
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Tue Aug 11 00:00:00 EDT 2009
Identification of nonepithelial multipotent cells in the embryonic olfactory mucosa.
Stem cells (Dayton, Ohio)
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Dendritic branching of olfactory bulb mitral and tufted cells: regulation by TrkB.
PloS one
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BMC neuroscience
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TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis.
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Setting the conditions for efficient, robust and reproducible generation of functionally active neurons from adult subventricular zone-derived neural stem cells.
Cell death and differentiation
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Morphological changes in spiral ganglion cells after intracochlear application of brain-derived neurotrophic factor in deafened guinea pigs.
Hearing research
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Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor.
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Fri Nov 28 00:00:00 EST 2008
Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning.
Mechanisms of development
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Neurotrophins mediate human embryonic stem cell survival.
Nature biotechnology
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Sulfation patterns of glycosaminoglycans encode molecular recognition and activity.
Nature chemical biology
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Protection by GDNF and other trophic factors against the dopamine-depleting effects of neurotoxic doses of methamphetamine.
Annals of the New York Academy of Sciences
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Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments.
Molecular systems biology
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