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This peptide corresponds to 16 amino acids near the amino terminus of human NALP14.
PEP-1143 can be used as a blocking peptide with polyclonal antibody PA5-21029.
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP14 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. While little is known about the function of NALP14, it has been suggested that it may play a role in spermatogenesis and that mutations in the NALP14 gene might cause spermatogenic failure.
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Protein Aliases: NACHT, leucine rich repeat and PYD containing 14; NACHT, LRR and PYD containing protein 14; NACHT, LRR and PYD domains-containing protein 14; NLR family, pyrin domain containing 14; Nucleotide-binding oligomerization domain protein 5; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 14
Gene Aliases: CLR11.2; GC-LRR; NALP14; NLRP14; NOD5; PAN8
UniProt ID: (Human) Q86W24
Entrez Gene ID: (Human) 338323
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