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Product Details
RP-108627
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
KVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHNKS
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (95%), Rat (95%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-84944. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The protein tyrosine phosphatase (PTP) family of proteins are signaling molecules that regulate processes such as cell growth, cell differentiation, oncogenic transformation and the mitotic cycle. PTPN21 (protein tyrosine phosphatase, non-receptor type 21), also known as PTPD1 or PTPRL10, is a 1,174 amino acid member of the PTP family and localizes to both the cytoplasm and the cytoskeleton. Containing one FERM domain and one tyrosine-protein phosphatase domain, PTPN21 functions to catalyze the water-dependent conversion of a protein tyrosine phosphate into a protein tyrosine and a free phosphate and, via this catalytic activity, may be involved in liver regeneration and spermatogenesis. The gene encoding PTPN21 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21); Protein-tyrosine phosphatase D1; Tyrosine-protein phosphatase non-receptor type 21
Gene Aliases: PTPD1; PTPN21; PTPRL10
UniProt ID: (Human) Q16825
Entrez Gene ID: (Human) 11099
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