Gibco

Human SCF Recombinant Protein, PeproTech®

Human SCF Protein in Functional Assay (Functional)

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Human SCF Protein (300-07-10UG) in Functional

Bioassay analysis of Human SCF Recombinant Protein, PeproTech® (Product # 300-07-1MG).

Product Image Gallery

Product Details

300-07-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

Flow Cytometry (Flow)

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 490 publications 490 publications

Miscellaneous PubMed (Misc)

View 51 publications 51 publications

Product Specifications

Species

Human

Published species

Hamster, Human, Mouse, Non-human primate, Pig, Rabbit, Rat, Virus

Expression System

E. coli

Amino acid sequence

MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA

Molecular weight

18.4 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.

British journal of haematology

Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y

300-07 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.

Sat Jul 01 00:00:00 EDT 2023

Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages.

The Journal of cell biology

Pellegrino E,Aylan B,Bussi C,Fearns A,Bernard EM,Athanasiadi N,Santucci P,Botella L,Gutierrez MG

300-07 was used in In vitro experiments to find peroxisomes increased ROS levels during Mtb WT infection.

Mon Dec 04 00:00:00 EST 2023

Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction.

Communications biology

Breitmeyer R,Vogel S,Heider J,Hartmann SM,Wüst R,Keller AL,Binner A,Fitzgerald JC,Fallgatter AJ,Volkmer H

300-07 was used in Cell Culture to present a co-culture model of neurons and microglia, both of human origin, to show increased susceptibility of neurons to microglia-like cells derived from SCZ patients.

Sat Apr 29 00:00:00 EDT 2023

An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming.

Science advances

Weng M,Hu H,Graus MS,Tan DS,Gao Y,Ren S,Ho DHH,Langer J,Holzner M,Huang Y,Ling GS,Lai CSW,Francois M,Jauch R

300-07 was used in In vitro experiments to report iNSC reprogramming from embryonic and aged mouse fibroblasts as well as from human blood using an engineered Sox17 (eSox17FNV).

Fri Aug 25 00:00:00 EDT 2023

ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages.

Nature microbiology

Aylan B,Bernard EM,Pellegrino E,Botella L,Fearns A,Athanasiadi N,Bussi C,Santucci P,Gutierrez MG

300-07 was used in Cell Culture to conclude that ATG7 and ATG14 are both required for restricting Mtb replication in human macrophages.

Mon May 01 00:00:00 EDT 2023

C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages.

iScience

Tian L,Li H,Zhao P,Liu Y,Lu Y,Zhong R,Jin Y,Tan T,Cheng Y

300-07 was used in Cell Culture to provide a comprehensive overview of the cancer-specific immune signature of monocytes and macrophages and reveals tumor-associated biomarkers as potential therapeutic targets for SCLC.

Fri Oct 20 00:00:00 EDT 2023

Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors.

Methods in molecular biology (Clifton, N.J.)

Chen SW,Wong YH

300-07 was used in Cell Culture to provide a stepwise protocol for the simple, robust, and efficient differentiation of hiPSCs into microglia-like cells (iMGs) by overexpression of SPI1 and CEBPA.

Mon Jun 12 00:00:00 EDT 2023

Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B.

The Journal of clinical investigation

Azad P,Zhou D,Tu HC,Villafuerte FC,Traver D,Rana TM,Haddad GG

300-07 was used in In vitro experiments to conclude that HIKER regulates erythropoiesis in Monge's disease and acts through at least one specific target, CSNK2B, a casein kinase.

Thu Jun 01 00:00:00 EDT 2023

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.

Nature neuroscience

Dräger NM,Sattler SM,Huang CT,Teter OM,Leng K,Hashemi SH,Hong J,Aviles G,Clelland CD,Zhan L,Udeochu JC,Kodama L,Singleton AB,Nalls MA,Ichida J,Ward ME,Faghri F,Gan L,Kampmann M

300-07 was used in In vitro experiments to present a screening platform to systematically elucidate functional consequences of genetic perturbations in human induced pluripotent stem cell-derived microglia.

Thu Sep 01 00:00:00 EDT 2022

Disease-associated mutations in topoisomerase IIβ result in defective NK cells.

The Journal of allergy and clinical immunology

Broderick L,Clay GM,Blum RH,Liu Y,McVicar R,Papes F,Booshehri LM,Cowell IG,Austin CA,Putnam CD,Kaufman DS

300-07 was used in Cell Culture to support that Hoffman syndrome-associated mutations in TOP2B impact NK-cell development and function in murine and human models.

Wed Jun 01 00:00:00 EDT 2022

The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis.

Leukemia

Stavast CJ,van Zuijen I,Karkoulia E,Özçelik A,van Hoven-Beijen A,Leon LG,Voerman JSA,Janssen GMC,van Veelen PA,Burocziova M,Brouwer RWW,van IJcken WFJ,Maas A,Bindels EM,van der Velden VHJ,Schliehe C,Katsikis PD,Alberich-Jorda M,Erkeland SJ

300-07 was used in Cell Culture to investigate miRNA-139 in acute myeloid leukemia.

Tue Mar 01 00:00:00 EST 2022

A comparison of DNA repair pathways to achieve a site-specific gene modification of the Bruton's tyrosine kinase gene.

Molecular therapy. Nucleic acids

Gray DH,Santos J,Keir AG,Villegas I,Maddock S,Trope EC,Long JD,Kuo CY

300-07 was used in Cell Culture to compare three methods of targeted insertion — homology-directed repair (HDR), homology-independent targeted integration (HITI), and precise integration into target chromosome (PITCh) — to achieve a permanent gene-therapy-based cure for X-linked agammaglobulinemia.

Tue Mar 08 00:00:00 EST 2022

Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.

Cellular and molecular life sciences : CMLS

Solomon S,Sampathkumar NK,Carre I,Mondal M,Chennell G,Vernon AC,Ruepp MD,Mitchell JC

300-07 was used in Sample Preparation to investigate P522R in Alzheimer’s disease.

Wed Jul 27 00:00:00 EDT 2022

Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.

EMBO reports

Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB

300-07 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.

Thu Feb 03 00:00:00 EST 2022

Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.

EMBO reports

Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB

300-07 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.

Thu Feb 03 00:00:00 EST 2022

Patient-specific, re-engineered cardiomyocyte model confirms the circumstance-dependent arrhythmia risk associated with the African-specific common SCN5A polymorphism p.S1103Y: Implications for the increased sudden deaths observed in black individuals during the COVID-19 pandemic.

Heart rhythm

Hamrick SK,John Kim CS,Tester DJ,Giudicessi JR,Ackerman MJ

300-07 was used in Cell Culture to ascertain the effects of acidosis and hydroxychloroquine (HCQ) on the action potential duration (APD) in a patient-specific induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of p.S1103Y-SCN5A.

Sun May 01 00:00:00 EDT 2022

A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.

RNA (New York, N.Y.)

Hug N,Aitken S,Longman D,Raab M,Armes H,Mann AR,Rio-Machin A,Fitzgibbon J,Rouault-Pierre K,Cáceres JF

300-07 was used in In vitro experiments to investigate NMD factors and the role of DNX34 in the spliceosome.

Thu Sep 01 00:00:00 EDT 2022

Quantitative Proteomics of Polarised Macrophages Derived from Induced Pluripotent Stem Cells.

Biomedicines

Murugesan G,Davidson L,Jannetti L,Crocker PR,Weigle B

300-07 was used in Cell Culture to generate and culture embroyoid bodies (iPSCs). Polarised to either M1 or M2, the macrophages were subjected to quantitative proteomic analysis gaining further insight into their functionalities.

Sun Jan 23 00:00:00 EST 2022

Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis.

mBio

Santucci P,Aylan B,Botella L,Bernard EM,Bussi C,Pellegrino E,Athanasiadi N,Gutierrez MG

300-07 was used in Cell Culture to describe a dual live imaging approach to monitor mycobacterial pH homeostasis, host cell environment, and antibiotic action, and show that intracellular localization of M. tuberculosis affects the efficacy of pyrazinamide.

Tue Apr 26 00:00:00 EDT 2022

Using Cryo-ET to distinguish platelets during pre-acute myeloid leukemia from steady state hematopoiesis.

Communications biology

Wang Y,Huo T,Tseng YJ,Dang L,Yu Z,Yu W,Foulks Z,Murdaugh RL,Ludtke SJ,Nakada D,Wang Z

Thu Jan 20 00:00:00 EST 2022

Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.

Cell stem cell

Jin M,Xu R,Wang L,Alam MM,Ma Z,Zhu S,Martini AC,Jadali A,Bernabucci M,Xie P,Kwan KY,Pang ZP,Head E,Liu Y,Hart RP,Jiang P

300-07 was used in Cell Culture to provide in vivo evidence that human microglia respond to pathological tau by exhibiting dystrophic phenotypes.

Thu Jul 07 00:00:00 EDT 2022

Generation, expansion, and drug treatment of hematopoietic progenitor cells derived from human iPSCs.

STAR protocols

Dannenmann B,Skokowa J

300-07 was used in Cell Culture to provide protocol for generation of HPCs from iPSCs followed by HPC expansion on Sl/Sl feeder cells expressing FLT3L.

Fri Jun 17 00:00:00 EDT 2022

Decoding the pathogenesis of Diamond-Blackfan anemia using single-cell RNA-seq.

Cell discovery

Wang B,Wang C,Wan Y,Gao J,Ma Y,Zhang Y,Tong J,Zhang Y,Liu J,Chang L,Xu C,Shen B,Chen Y,Jiang E,Kurita R,Nakamura Y,Lim KC,Engel JD,Zhou J,Cheng T,Zhu X,Zhu P,Shi L

300-07 was used in Cell Culture to demonstrate that interferon-mediated cell cycle control underlies the clinical efficacy of glucocorticoids.

Tue May 10 00:00:00 EDT 2022

Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters.

iScience

van Gils N,Verhagen HJMP,Broux M,Martiáñez T,Denkers F,Vermue E,Rutten A,Csikós T,Demeyer S,Çil M,Al M,Cools J,Janssen JJWM,Ossenkoppele GJ,Menezes RX,Smit L

300-07 was used in Cell Culture to reveal plasticity of anthracycline resistance in AML cells and highlight the potential of transcriptional reprogramming by epigenetic-based therapeutics to target chemotherapy-resistant AML cells.

Fri Sep 16 00:00:00 EDT 2022

Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells.

Nature genetics

Qin K,Huang P,Feng R,Keller CA,Peslak SA,Khandros E,Saari MS,Lan X,Mayuranathan T,Doerfler PA,Abdulmalik O,Giardine B,Chou ST,Shi J,Hardison RC,Weiss MJ,Blobel GA

300-07 was used in Cell Culture to identify via a CRISPR-Cas9 genetic screen two members of the NFI transcription factor family-NFIA and NFIX-as HBG1/2 repressors.

Wed Jun 01 00:00:00 EDT 2022

Single-nucleotide-level mapping of DNA regulatory elements that control fetal hemoglobin expression.

Nature genetics

Cheng L,Li Y,Qi Q,Xu P,Feng R,Palmer L,Chen J,Wu R,Yee T,Zhang J,Yao Y,Sharma A,Hardison RC,Weiss MJ,Cheng Y

300-07 was used in Cell Culture to develop a high-throughput framework to map noncoding DNA in sickle cell disease.

Tue Jun 01 00:00:00 EDT 2021

N⁶-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.

Cancer cell

Cheng Y,Xie W,Pickering BF,Chu KL,Savino AM,Yang X,Luo H,Nguyen DT,Mo S,Barin E,Velleca A,Rohwetter TM,Patel DJ,Jaffrey SR,Kharas MG

300-07 was used in In vitro experiments to investigate How N6-Methyladenosine dictates its diverse molecular and cellular effects in leukemias.

Mon Jul 12 00:00:00 EDT 2021

Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia.

Cancer discovery

Montefiori LE,Bendig S,Gu Z,Chen X,Pölönen P,Ma X,Murison A,Zeng A,Garcia-Prat L,Dickerson K,Iacobucci I,Abdelhamed S,Hiltenbrand R,Mead PE,Mehr CM,Xu B,Cheng Z,Chang TC,Westover T,Ma J,Stengel A,Kimura S,Qu C,Valentine MB,Rashkovan M,Luger S,Litzow MR,Rowe JM,den Boer ML,Wang V,Yin J,Kornblau SM,Hunger SP,Loh ML,Pui CH,Yang W,Crews KR,Roberts KG,Yang JJ,Relling MV,Evans WE,Stock W,Paietta EM,Ferrando AA,Zhang J,Kern W,Haferlach T,Wu G,Dick JE,Klco JM,Haferlach C,Mullighan CG

300-07 was used in In vitro experiments to identify oncogenic deregulation of BCL11B driven by diverse structural alterations, including de novo superenhancer generation, as the driving feature of a subset of lineage-ambiguous leukemias that transcend current diagnostic boundaries.

Mon Nov 01 00:00:00 EDT 2021

M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity.

Signal transduction and targeted therapy

Zhao HY,Zhang YY,Xing T,Tang SQ,Wen Q,Lyu ZS,Lv M,Wang Y,Xu LP,Zhang XH,Kong Y,Huang XJ

Fri Jun 18 00:00:00 EDT 2021

Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms.

Blood

Mosca M,Hermange G,Tisserand A,Noble R,Marzac C,Marty C,Le Sueur C,Campario H,Vertenoeil G,El-Khoury M,Catelain C,Rameau P,Gella C,Lenglet J,Casadevall N,Favier R,Solary E,Cassinat B,Kiladjian JJ,Constantinescu SN,Pasquier F,Hochberg ME,Raslova H,Villeval JL,Girodon F,Vainchenker W,Cournède PH,Plo I

Thu Dec 02 00:00:00 EST 2021

Dynamic CTCF binding directly mediates interactions among cis-regulatory elements essential for hematopoiesis.

Blood

Qi Q,Cheng L,Tang X,He Y,Li Y,Yee T,Shrestha D,Feng R,Xu P,Zhou X,Pruett-Miller S,Hardison RC,Weiss MJ,Cheng Y

Thu Mar 11 00:00:00 EST 2021

Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging.

Cell stem cell

Kruta M,Sunshine MJ,Chua BA,Fu Y,Chawla A,Dillingham CH,Hidalgo San Jose L,De Jong B,Zhou FJ,Signer RAJ

Thu Nov 04 00:00:00 EDT 2021

MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia.

Cell stem cell

Rodríguez A,Zhang K,Färkkilä A,Filiatrault J,Yang C,Velázquez M,Furutani E,Goldman DC,García de Teresa B,Garza-Mayén G,McQueen K,Sambel LA,Molina B,Torres L,González M,Vadillo E,Pelayo R,Fleming WH,Grompe M,Shimamura A,Hautaniemi S,Greenberger J,Frías S,Parmar K,D'Andrea AD

300-07 was used in In vitro experiments to identify determinants of bone marrow failure, we performed single-cell transcriptome profiling of primary hematopoietic stem and progenitor cells from Fanconi anemia patients.

Thu Jan 07 00:00:00 EST 2021

Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms.

Cell stem cell

Van Egeren D,Escabi J,Nguyen M,Liu S,Reilly CR,Patel S,Kamaz B,Kalyva M,DeAngelo DJ,Galinsky I,Wadleigh M,Winer ES,Luskin MR,Stone RM,Garcia JS,Hobbs GS,Camargo FD,Michor F,Mullally A,Cortes-Ciriano I,Hormoz S

Thu Mar 04 00:00:00 EST 2021

Dissecting ELANE neutropenia pathogenicity by human HSC gene editing.

Cell stem cell

Rao S,Yao Y,Soares de Brito J,Yao Q,Shen AH,Watkinson RE,Kennedy AL,Coyne S,Ren C,Zeng J,Serbin AV,Studer S,Ballotti K,Harris CE,Luk K,Stevens CS,Armant M,Pinello L,Wolfe SA,Chiarle R,Shimamura A,Lee B,Newburger PE,Bauer DE

Thu May 06 00:00:00 EDT 2021

Principles of signaling pathway modulation for enhancing human naive pluripotency induction.

Cell stem cell

Bayerl J,Ayyash M,Shani T,Manor YS,Gafni O,Massarwa R,Kalma Y,Aguilera-Castrejon A,Zerbib M,Amir H,Sheban D,Geula S,Mor N,Weinberger L,Naveh Tassa S,Krupalnik V,Oldak B,Livnat N,Tarazi S,Tawil S,Wildschutz E,Ashouokhi S,Lasman L,Rotter V,Hanna S,Ben-Yosef D,Novershtern N,Viukov S,Hanna JH

Thu Sep 02 00:00:00 EDT 2021

A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors.

Cellular & molecular immunology

Moirangthem RD,Ma K,Lizot S,Cordesse A,Olivré J,de Chappedelaine C,Joshi A,Cieslak A,Tchen J,Cagnard N,Asnafi V,Rausell A,Simons L,Zuber J,Taghon T,Staal FJT,Pflumio F,Six E,Cavazzana M,Lagresle-Peyrou C,Soheili T,André I

Thu Jul 01 00:00:00 EDT 2021

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression.

Molecular cell

Lan X,Ren R,Feng R,Ly LC,Lan Y,Zhang Z,Aboreden N,Qin K,Horton JR,Grevet JD,Mayuranathan T,Abdulmalik O,Keller CA,Giardine B,Hardison RC,Crossley M,Weiss MJ,Cheng X,Shi J,Blobel GA

300-07 was used in Cell Culture to identify via a CRISPR-Cas9 genetic screen ZNF410, a pentadactyl DNA-binding protein that in human erythroid cells directly activates only a single gene, the NuRD component CHD4.

Thu Jan 21 00:00:00 EST 2021

ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.

Molecular cell

Di Marcantonio D,Martinez E,Kanefsky JS,Huhn JM,Gabbasov R,Gupta A,Krais JJ,Peri S,Tan Y,Skorski T,Dorrance A,Garzon R,Goldman AR,Tang HY,Johnson N,Sykes SM

300-07 was used in In vitro experiments to investigate the role of ATF3 expression on cell cycle progression in acute myeloid leukemia.

Thu Jul 01 00:00:00 EDT 2021

Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.

Science translational medicine

Reyes M,Filbin MR,Bhattacharyya RP,Sonny A,Mehta A,Billman K,Kays KR,Pinilla-Vera M,Benson ME,Cosimi LA,Hung DT,Levy BD,Villani AC,Sade-Feldman M,Baron RM,Goldberg MB,Blainey PC,Hacohen N

Wed Jun 16 00:00:00 EDT 2021

JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML.

The Journal of experimental medicine

Dagher T,Maslah N,Edmond V,Cassinat B,Vainchenker W,Giraudier S,Pasquier F,Verger E,Niwa-Kawakita M,Lallemand-Breitenbach V,Plo I,Kiladjian JJ,Villeval JL,de Thé H

Mon Feb 01 00:00:00 EST 2021

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

The Journal of experimental medicine

Louka E,Povinelli B,Rodriguez-Meira A,Buck G,Wen WX,Wang G,Sousos N,Ashley N,Hamblin A,Booth CAG,Roy A,Elliott N,Iskander D,de la Fuente J,Fordham N,O'Byrne S,Inglott S,Norfo R,Salio M,Thongjuea S,Rao A,Roberts I,Mead AJ

Mon Feb 01 00:00:00 EST 2021

Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.

The Journal of experimental medicine

Le Coz C,Nguyen DN,Su C,Nolan BE,Albrecht AV,Xhani S,Sun D,Demaree B,Pillarisetti P,Khanna C,Wright F,Chen PA,Yoon S,Stiegler AL,Maurer K,Garifallou JP,Rymaszewski A,Kroft SH,Olson TS,Seif AE,Wertheim G,Grant SFA,Vo LT,Puck JM,Sullivan KE,Routes JM,Zakharova V,Shcherbina A,Mukhina A,Rudy NL,Hurst ACE,Atkinson TP,Boggon TJ,Hakonarson H,Abate AR,Hajjar J,Nicholas SK,Lupski JR,Verbsky J,Chinn IK,Gonzalez MV,Wells AD,Marson A,Poon GMK,Romberg N

Mon Jul 05 00:00:00 EDT 2021

Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.

EMBO molecular medicine

Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P

Fri Mar 05 00:00:00 EST 2021

Modeling genetic epileptic encephalopathies using brain organoids.

EMBO molecular medicine

Steinberg DJ,Repudi S,Saleem A,Kustanovich I,Viukov S,Abudiab B,Banne E,Mahajnah M,Hanna JH,Stern S,Carlen PL,Aqeilan RI

Mon Aug 09 00:00:00 EDT 2021

Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia.

Developmental cell

Ma Y,Liu S,Gao J,Chen C,Zhang X,Yuan H,Chen Z,Yin X,Sun C,Mao Y,Zhou F,Shao Y,Liu Q,Xu J,Cheng L,Yu D,Li P,Yi P,He J,Geng G,Guo Q,Si Y,Zhao H,Li H,Banes GL,Liu H,Nakamura Y,Kurita R,Huang Y,Wang X,Wang F,Fang G,Engel JD,Shi L,Zhang YE,Yu J

300-07 was used in Sample Preparation (FC/FACS) to investigate pseudogene phenotypic effects.

Mon Feb 22 00:00:00 EST 2021

Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.

Leukemia

Thomas ME,Abdelhamed S,Hiltenbrand R,Schwartz JR,Sakurada SM,Walsh M,Song G,Ma J,Pruett-Miller SM,Klco JM

Mon Nov 01 00:00:00 EDT 2021

Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling.

Molecular therapy. Nucleic acids

Kazuki Y,Uno N,Abe S,Kajitani N,Kazuki K,Yakura Y,Sawada C,Takata S,Sugawara M,Nagashima Y,Okada A,Hiratsuka M,Osaki M,Ferrari G,Tedesco FS,Nishikawa S,Fukumoto K,Takayanagi SI,Kunisato A,Kaneko S,Oshimura M,Tomizuka K

Fri Mar 05 00:00:00 EST 2021

Reducing TGF-β1 cooperated with StemRegenin 1 promoted the expansion ex vivo of cord blood CD34⁺ cells by inhibiting AhR signalling.

Cell proliferation

Zhu X,Sun Q,Tan WS,Cai H

Mon Mar 01 00:00:00 EST 2021

Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.

Stem cells translational medicine

Tanaka R,Ito-Hirano R,Fujimura S,Arita K,Hagiwara H,Mita T,Itoh M,Kawaji H,Ogawa T,Watada H,Masuda H,Asahara T,Mizuno H

Tue Jun 01 00:00:00 EDT 2021

Enhanced self-renewal of human long-term hematopoietic stem cells by a sulfamoyl benzoate derivative targeting p18INK4C.

Blood advances

Li Y,Zhang W,Zhang Y,Ding Y,Yang M,He M,Liu X,Gu J,Xu S,Feng Z,Li Y,Yin J,Gao H,Song H,Xu H,Wang C,Ji Q,Ma S,Yang W,Yuan W,Xie XQ,Cheng T,Gao Y

Tue Sep 14 00:00:00 EDT 2021

CRISPR-edited megakaryocytes for rapid screening of platelet gene functions.

Blood advances

Montenont E,Bhatlekar S,Jacob S,Kosaka Y,Manne BK,Lee O,Parra-Izquierdo I,Tugolukova E,Tolley ND,Rondina MT,Bray PF,Rowley JW

Tue May 11 00:00:00 EDT 2021

Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency.

Blood advances

Zoccolillo M,Brigida I,Barzaghi F,Scala S,Hernández RJ,Basso-Ricci L,Colantuoni M,Pettinato E,Sergi LS,Milardi G,Capasso P,Lombardo A,Gregori S,Sanvito F,Schena F,Cesaro S,Conti F,Pession A,Benedetti F,Gattorno M,Lee PY,Naldini L,Cicalese MP,Aiuti A,Mortellaro A

Tue Aug 24 00:00:00 EDT 2021

Digestion and Transport across the Intestinal Epithelium Affects the Allergenicity of Ara h 1 and 3 but Not of Ara h 2 and 6.

Molecular nutrition & food research

Smits M,Nooijen I,Redegeld F,de Jong A,Le TM,Knulst A,Houben G,Verhoeckx K

Mon Mar 01 00:00:00 EST 2021

Human induced pluripotent stem cell-derived macrophages ameliorate liver fibrosis.

Stem cells (Dayton, Ohio)

Pouyanfard S,Meshgin N,Cruz LS,Diggle K,Hashemi H,Pham TV,Fierro M,Tamayo P,Fanjul A,Kisseleva T,Kaufman DS

Wed Dec 01 00:00:00 EST 2021

CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.

Stem cells (Dayton, Ohio)

Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM

Sat May 01 00:00:00 EDT 2021

CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.

Stem cells (Dayton, Ohio)

Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM

Sat May 01 00:00:00 EDT 2021

In vitro and in vivo detection of tunneling nanotubes in normal and pathological osteoclastogenesis involving osteoclast fusion.

Laboratory investigation; a journal of technical methods and pathology

Zhang JQ,Takahashi A,Gu JY,Zhang X,Kyumoto-Nakamura Y,Kukita A,Uehara N,Hiura H,Yamaza T,Kukita T

Wed Dec 01 00:00:00 EST 2021

A Critical Role for Na⁺/H⁺ Exchanger Regulatory Factor 1 in Modulating FcεRI-Mediated Mast Cell Activation.

Journal of immunology (Baltimore, Md. : 1950)

Kammala AK,Syed M,Yang C,Occhiuto CJ,Subramanian H

Mon Feb 01 00:00:00 EST 2021

Bortezomib suppresses self-renewal and leukemogenesis of leukemia stem cell by NF-ĸB-dependent inhibition of CDK6 in MLL-rearranged myeloid leukemia.

Journal of cellular and molecular medicine

Zhou B,Qin Y,Zhou J,Ruan J,Xiong F,Dong J,Huang X,Yu Z,Gao S

Mon Mar 01 00:00:00 EST 2021

HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells.

Stem cells international

Kwon YW,Ahn HS,Lee JW,Yang HM,Cho HJ,Kim SJ,Lee SH,Yang HM,Jang HD,Kim SJ,Kim HS

Tue Jun 08 00:00:00 EDT 2021

Generation of three induced pluripotent stem cell lines, SCVIi003-A, SCVIi004-A, SCVIi005-A, from patients with ARVD/C caused by heterozygous mutations in the PKP2 gene.

Stem cell research

Jahng JWS,Black KE,Liu L,Bae HR,Perez M,Ashley EA,Sallam K,Wu JC

300-07 was used in Cell Culture to investigate induced pluripotent stem cell generation from patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Sat May 01 00:00:00 EDT 2021

Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome.

Nature communications

Kennedy AL,Myers KC,Bowman J,Gibson CJ,Camarda ND,Furutani E,Muscato GM,Klein RH,Ballotti K,Liu S,Harris CE,Galvin A,Malsch M,Dale D,Gansner JM,Nakano TA,Bertuch A,Vlachos A,Lipton JM,Castillo P,Connelly J,Churpek J,Edwards JR,Hijiya N,Ho RH,Hofmann I,Huang JN,Keel S,Lamble A,Lau BW,Norkin M,Stieglitz E,Stock W,Walkovich K,Boettcher S,Brendel C,Fleming MD,Davies SM,Weller EA,Bahl C,Carter SL,Shimamura A,Lindsley RC

Fri Feb 26 00:00:00 EST 2021

EGR1 is a gatekeeper of inflammatory enhancers in human macrophages.

Science advances

Trizzino M,Zucco A,Deliard S,Wang F,Barbieri E,Veglia F,Gabrilovich D,Gardini A

Fri Jan 01 00:00:00 EST 2021

Identification of a class of non-conventional ER-stress-response-derived immunogenic peptides.

Cell reports

Melacarne A,Ferrari V,Tiraboschi L,Mishto M,Liepe J,Aralla M,Marconato L,Lizier M,Pozzi C,Zeira O,Penna G,Rescigno M

Tue Jul 06 00:00:00 EDT 2021

Stem-cell-derived human microglia transplanted into mouse brain to study human disease.

Nature protocols

Fattorelli N,Martinez-Muriana A,Wolfs L,Geric I,De Strooper B,Mancuso R

300-07 was used in Sample Preparation to explain the step-by-step workflow that includes in vitro microglia differentiation from human PSCs, transplantation into the mouse brain and quantitative analysis of engraftment. This approach is more optimized and more efficient approach that yields up to 80% chimerism when compared to current differentiation and xenotransplantation protocols.

Mon Feb 01 00:00:00 EST 2021

Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis.

Cancers

Masselli E,Carubbi C,Pozzi G,Percesepe A,Campanelli R,Villani L,Gobbi G,Bonomini S,Roti G,Rosti V,Massa M,Barosi G,Vitale M

300-07 was used in In vitro experiments to conclude that the identification of the role of the CCL2/CCR2 chemokine system in PMF adds a novel element to the pathophysiological picture of the disease, with clinical and therapeutic implications.

Sat May 22 00:00:00 EDT 2021

Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice.

Communications biology

Barcia Durán JG,Lu T,Houghton S,Geng F,Schreiner R,Xiang J,Rafii S,Redmond D,Lis R

Thu Mar 25 00:00:00 EDT 2021

Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis.

Nature communications

Biavasco R,Lettera E,Giannetti K,Gilioli D,Beretta S,Conti A,Scala S,Cesana D,Gallina P,Norelli M,Basso-Ricci L,Bondanza A,Cavalli G,Ponzoni M,Dagna L,Doglioni C,Aiuti A,Merelli I,Di Micco R,Montini E

Tue Jul 27 00:00:00 EDT 2021

ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma.

Cell reports

De Bacco F,Orzan F,Erriquez J,Casanova E,Barault L,Albano R,D'Ambrosio A,Bigatto V,Reato G,Patanè M,Pollo B,Kuesters G,Dell'Aglio C,Casorzo L,Pellegatta S,Finocchiaro G,Comoglio PM,Boccaccio C

Tue Jul 27 00:00:00 EDT 2021

The miR-424(322)/503 gene cluster regulates pro- versus anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling.

Cell reports

Zyulina V,Yan KK,Ju B,Schwarzenberger E,Passegger C,Tam-Amersdorfer C,Pan Q,Sconocchia T,Pollack C,Shaner B,Zebisch A,Easton J,Yu J,Silva JM,Strobl H

Tue Apr 27 00:00:00 EDT 2021

Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic.

Nature communications

Zhang X,Luo M,Dastagir SR,Nixon M,Khamhoung A,Schmidt A,Lee A,Subbiah N,McLaughlin DC,Moore CL,Gribble M,Bayhi N,Amin V,Pepi R,Pawar S,Lyford TJ,Soman V,Mellen J,Carpenter CL,Turka LA,Wickham TJ,Chen TF

Tue May 11 00:00:00 EDT 2021

Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.

Science advances

Trapecar M,Wogram E,Svoboda D,Communal C,Omer A,Lungjangwa T,Sphabmixay P,Velazquez J,Schneider K,Wright CW,Mildrum S,Hendricks A,Levine S,Muffat J,Lee MJ,Lauffenburger DA,Trumper D,Jaenisch R,Griffith LG

300-07 was used in In vitro experiments to develop a mesofluidic platform technology to study gut-liver-cerebral interactions in the context of Parkinson's disease (PD).

Fri Jan 01 00:00:00 EST 2021

Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.

iScience

Zee BM,Poels KE,Yao CH,Kawabata KC,Wu G,Duy C,Jacobus WD,Senior E,Endress JE,Jambhekar A,Lovitch SB,Ma J,Dhall A,Harris IS,Blanco MA,Sykes DB,Licht JD,Weinstock DM,Melnick A,Haigis MC,Michor F,Shi Y

Fri Jun 25 00:00:00 EDT 2021

3'HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression.

eLife

Himadewi P,Wang XQD,Feng F,Gore H,Liu Y,Yu L,Kurita R,Nakamura Y,Pfeifer GP,Liu J,Zhang X

300-07 was used in Sample Preparation (FC/FACS) to suggest that genetic editing of the 3'HS1 CTCF binding site can have therapeutic implications to treat hemoglobinopathies.

Wed Sep 29 00:00:00 EDT 2021

Dyshomeostatic modulation of Ca²⁺-activated K⁺ channels in a human neuronal model of KCNQ2 encephalopathy.

eLife

Simkin D,Marshall KA,Vanoye CG,Desai RR,Bustos BI,Piyevsky BN,Ortega JA,Forrest M,Robertson GL,Penzes P,Laux LC,Lubbe SJ,Millichap JJ,George AL,Kiskinis E

300-07 was used in Cell Culture to measure the functional properties of differentiated excitatory neurons in an induced pluripotent stem cell (iPSCs) and gene editing established disease model.

Fri Feb 05 00:00:00 EST 2021

Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays.

STAR protocols

Rodríguez A,Filiatrault J,Flores-Guzmán P,Mayani H,Parmar K,D'Andrea AD

300-07 was used in Cell Culture to present protocols for the isolation of human and murine HSPCs using manual and FACS-assisted techniques.

Fri Dec 17 00:00:00 EST 2021

Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays.

STAR protocols

Rodríguez A,Filiatrault J,Flores-Guzmán P,Mayani H,Parmar K,D'Andrea AD

300-07 was used in Cell Culture to present protocols for the isolation of human and murine HSPCs using manual and FACS-assisted techniques.

Fri Dec 17 00:00:00 EST 2021

Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells.

Cells

Lazki-Hagenbach P,Ali H,Sagi-Eisenberg R

300-07 was used in Cell Culture to show that the underlying mechanisms of MRGPRX2-triggered MC degranulation in either LAD-2 or RBL-MRGPRX2 cells are different from those elicited by its rodent orthologs.

Fri Feb 12 00:00:00 EST 2021

Directly reprogrammed natural killer cells for cancer immunotherapy.

Nature biomedical engineering

Kim HS,Kim JY,Seol B,Song CL,Jeong JE,Cho YS

Mon Nov 01 00:00:00 EDT 2021

The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.

Communications biology

Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S

Mon Jun 07 00:00:00 EDT 2021

NOTCH-mediated ex vivo expansion of human hematopoietic stem and progenitor cells by culture under hypoxia.

Stem cell reports

Araki D,Fu JF,Huntsman H,Cordes S,Seifuddin F,Alvarado LJ,Cheruku PS,Cash A,Traba J,Li Y,Pirooznia M,Smith RH,Larochelle A

Tue Sep 14 00:00:00 EDT 2021

Molecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds.

Scientific reports

Marx-Blümel L,Marx C,Sonnemann J,Weise F,Hampl J,Frey J,Rothenburger L,Cirri E,Rahnis N,Koch P,Groth M,Schober A,Wang ZQ,Beck JF

Wed Oct 27 00:00:00 EDT 2021

Methylation of dual-specificity phosphatase 4 controls cell differentiation.

Cell reports

Su H,Jiang M,Senevirathne C,Aluri S,Zhang T,Guo H,Xavier-Ferrucio J,Jin S,Tran NT,Liu SM,Sun CW,Zhu Y,Zhao Q,Chen Y,Cable L,Shen Y,Liu J,Qu CK,Han X,Klug CA,Bhatia R,Chen Y,Nimer SD,Zheng YG,Iancu-Rubin C,Jin J,Deng H,Krause DS,Xiang J,Verma A,Luo M,Zhao X

Tue Jul 27 00:00:00 EDT 2021

Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia.

Nature communications

Goldfarb AN,Freeman KC,Sahu RK,Elagib KE,Holy M,Arneja A,Polanowska-Grabowska R,Gru AA,White Z,Khalil S,Kerins MJ,Ooi A,Leitinger N,Luckey CJ,Delehanty LL

Fri Mar 12 00:00:00 EST 2021

CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells.

Nature communications

Boutin J,Rosier J,Cappellen D,Prat F,Toutain J,Pennamen P,Bouron J,Rooryck C,Merlio JP,Lamrissi-Garcia I,Cullot G,Amintas S,Guyonnet-Duperat V,Ged C,Blouin JM,Richard E,Dabernat S,Moreau-Gaudry F,Bedel A

Fri Aug 13 00:00:00 EDT 2021

In vitro expansion of fetal liver hematopoietic stem cells.

Scientific reports

Bhardwaj R,Kumar L,Chhabra D,Mehra NK,Sharma A,Mohanty S,Kochupillai V

Fri Jun 04 00:00:00 EDT 2021

SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis.

Cell reports

Jung HS,Uenishi G,Park MA,Liu P,Suknuntha K,Raymond M,Choi YJ,Thomson JA,Ong IM,Slukvin II

300-07 was used in In vitro experiments to investigate the role and mechanisms of SOX17 in human pluripotent stem cells.

Tue Feb 16 00:00:00 EST 2021

CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data.

Nature communications

Amit I,Iancu O,Levy-Jurgenson A,Kurgan G,McNeill MS,Rettig GR,Allen D,Breier D,Ben Haim N,Wang Y,Anavy L,Hendel A,Yakhini Z

Mon May 24 00:00:00 EDT 2021

Higher PGD₂ production by synovial mast cells from rheumatoid arthritis patients compared with osteoarthritis patients via miR-199a-3p/prostaglandin synthetase 2 axis.

Scientific reports

Mishima S,Kashiwakura JI,Toyoshima S,Sasaki-Sakamoto T,Sano Y,Nakanishi K,Matsumoto K,Okayama Y

Thu Mar 11 00:00:00 EST 2021

Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy.

Cell reports. Medicine

Li YR,Zhou Y,Kim YJ,Zhu Y,Ma F,Yu J,Wang YC,Chen X,Li Z,Zeng S,Wang X,Lee D,Ku J,Tsao T,Hardoy C,Huang J,Cheng D,Montel-Hagen A,Seet CS,Crooks GM,Larson SM,Sasine JP,Wang X,Pellegrini M,Ribas A,Kohn DB,Witte O,Wang P,Yang L

300-07 was used in In vitro experiments to investigate cancer treatment by cell-based immunotherapy.

Tue Nov 16 00:00:00 EST 2021

The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells.

Nature communications

Sharma R,Dever DP,Lee CM,Azizi A,Pan Y,Camarena J,Köhnke T,Bao G,Porteus MH,Majeti R

Wed Jan 20 00:00:00 EST 2021

Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation.

Nature communications

Georgolopoulos G,Psatha N,Iwata M,Nishida A,Som T,Yiangou M,Stamatoyannopoulos JA,Vierstra J

Tue Nov 23 00:00:00 EST 2021

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.

Nature communications

Velten L,Story BA,Hernández-Malmierca P,Raffel S,Leonce DR,Milbank J,Paulsen M,Demir A,Szu-Tu C,Frömel R,Lutz C,Nowak D,Jann JC,Pabst C,Boch T,Hofmann WK,Müller-Tidow C,Trumpp A,Haas S,Steinmetz LM

Mon Mar 01 00:00:00 EST 2021

Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X.

iScience

de Castro Fonseca M,de Oliveira JF,Araujo BHS,Canateli C,do Prado PFV,Amorim Neto DP,Bosque BP,Rodrigues PV,de Godoy JVP,Tostes K,Filho HVR,Nascimento AFZ,Saito A,Tonoli CCC,Batista FAH,de Oliveira PSL,Figueira AC,Souza da Costa S,Krepischi ACV,Rosenberg C,Westfahl H,da Silva AJR,Franchini KG

Fri Aug 20 00:00:00 EDT 2021

Novel culture media enhances mononuclear cells from patients with chronic limb-threatening ischemia to increase vasculogenesis and anti-inflammatory effect.

Stem cell research & therapy

Chruewkamlow N,Pruekprasert K,Phutthakunphithak P,Acharayothin O,Prapassaro T,Hongku K,Hahtapornsawan S,Puangpunngam N,Chinsakchai K,Wongwanit C,Ruangsetakit C,Sermsathanasawadi N

300-07 was used in Cell Culture to evaluate the use of Quality and Quantity culture media to culture mononuclear cells from chronic limb-threatening ischemia patients.

Tue Sep 28 00:00:00 EDT 2021

The Expression of NTAL and Its Protein Interactors Is Associated With Clinical Outcomes in Acute Myeloid Leukemia.

Molecular & cellular proteomics : MCP

Thomé CH,Ferreira GA,Pereira-Martins DA,Augusto Dos Santos G,Almeida-Silveira DR,Weinhäuser I,Antônio de Souza G,Houtsma R,Schuringa JJ,Rego EM,Faça VM

Mon Mar 21 00:00:00 EDT 2022

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.

Nature communications

Rice S,Jackson T,Crump NT,Fordham N,Elliott N,O'Byrne S,Fanego MDML,Addy D,Crabb T,Dryden C,Inglott S,Ladon D,Wright G,Bartram J,Ancliff P,Mead AJ,Halsey C,Roberts I,Milne TA,Roy A

Thu Nov 25 00:00:00 EST 2021

Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells.

Cell death & disease

Malyukova A,Ujvari D,Yektaei-Karin E,Zovko A,Madapura HS,Keszei M,Nagy N,Lotfi K,Björn N,Wallvik J,Tamai M,Nguyen TTT,Akahane K,Inukai T,Stenke L,Salamon D

Sat Sep 25 00:00:00 EDT 2021

Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector.

Molecular therapy. Methods & clinical development

Seymour BJ,Singh S,Certo HM,Sommer K,Sather BD,Khim S,Clough C,Hale M,Pangallo J,Ryu BY,Khan IF,Adair JE,Rawlings DJ

Fri Mar 12 00:00:00 EST 2021

Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia.

Scientific reports

Hofmans M,Lammens T,Depreter B,Wu Y,Erlacher M,Caye A,Cavé H,Flotho C,de Haas V,Niemeyer CM,Stary J,Van Nieuwerburgh F,Deforce D,Van Loocke W,Van Vlierberghe P,Philippé J,De Moerloose B

Tue Feb 02 00:00:00 EST 2021

The Use of Induced Pluripotent Stem Cells to Study the Effects of Adenosine Deaminase Deficiency on Human Neutrophil Development.

Frontiers in immunology

Tsui M,Min W,Ng S,Dobbs K,Notarangelo LD,Dror Y,Grunebaum E

300-07 was used in Cell Culture to study the characterization of neutrophil developmental abnormalities and the mechanisms contributing to them to demonstrate the important role of adenosine deaminase (ADA) in the development and function of neutrophils while clarifying the mechanisms responsible for the neutrophil abnormalities in ADA-deficient patients.

Mon Dec 27 00:00:00 EST 2021

Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.

Nature

Palikuqi B,Nguyen DT,Li G,Schreiner R,Pellegata AF,Liu Y,Redmond D,Geng F,Lin Y,Gómez-Salinero JM,Yokoyama M,Zumbo P,Zhang T,Kunar B,Witherspoon M,Han T,Tedeschi AM,Scottoni F,Lipkin SM,Dow L,Elemento O,Xiang JZ,Shido K,Spence JR,Zhou QJ,Schwartz RE,De Coppi P,Rabbany SY,Rafii S

Tue Sep 01 00:00:00 EDT 2020

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.

Nature

Nikolaev M,Mitrofanova O,Broguiere N,Geraldo S,Dutta D,Tabata Y,Elci B,Brandenberg N,Kolotuev I,Gjorevski N,Clevers H,Lutolf MP

Tue Sep 01 00:00:00 EDT 2020

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.

Nature genetics

Lin KH,Rutter JC,Xie A,Pardieu B,Winn ET,Bello RD,Forget A,Itzykson R,Ahn YR,Dai Z,Sobhan RT,Anderson GR,Singleton KR,Decker AE,Winter PS,Locasale JW,Crawford L,Puissant A,Wood KC

300-07 was used in Cell Culture to perform pooled CRISPR-Cas9 knockout screens in acute myeloid leukemia (AML) cells treated with various chemotherapies to map the drug-dependent genetic basis of fitness trade-offs, a concept known as antagonistic pleiotropy (AP).

Wed Apr 01 00:00:00 EDT 2020

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.

Cancer cell

Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J

Mon Jul 13 00:00:00 EDT 2020

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies.

Cancer discovery

Su A,Ling F,Vaganay C,Sodaro G,Benaksas C,Dal Bello R,Forget A,Pardieu B,Lin KH,Rutter JC,Bassil CF,Fortin G,Pasanisi J,Antony-Debré I,Alexe G,Benoist JF,Pruvost A,Pikman Y,Qi J,Schlageter MH,Micol JB,Roti G,Cluzeau T,Dombret H,Preudhomme C,Fenouille N,Benajiba L,Golan HM,Stegmaier K,Lobry C,Wood KC,Itzykson R,Puissant A

300-07 was used in Cell Culture to investigate the effects of MTHFR for its therapeutic effects on acute myeloid leukemia.

Tue Dec 01 00:00:00 EST 2020

Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo.

Blood

Tarumoto Y,Lin S,Wang J,Milazzo JP,Xu Y,Lu B,Yang Z,Wei Y,Polyanskaya S,Wunderlich M,Gray NS,Stegmaier K,Vakoc CR

Thu Jan 02 00:00:00 EST 2020

Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171.

Blood

Subramaniam A,Žemaitis K,Talkhoncheh MS,Yudovich D,Bäckström A,Debnath S,Chen J,Jain MV,Galeev R,Gaetani M,Zubarev RA,Larsson J

Thu Nov 05 00:00:00 EST 2020

Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia.

Blood

Gebru MT,Atkinson JM,Young MM,Zhang L,Tang Z,Liu Z,Lu P,Dower CM,Chen L,Annageldiyev C,Sharma A,Imamura Kawasawa Y,Zhao Z,Miller BA,Claxton DF,Wang HG

Thu Aug 27 00:00:00 EDT 2020

Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency.

Blood

Grey W,Chauhan R,Piganeau M,Huerga Encabo H,Garcia-Albornoz M,McDonald NQ,Bonnet D

Thu Nov 26 00:00:00 EST 2020

Bone marrow-derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis.

Blood

Xiao Y,van Halteren AGS,Lei X,Borst J,Steenwijk E,de Wit T,Grabowska J,Voogd R,Kemps P,Picarsic J,van den Bos C,Borst J

Thu Nov 05 00:00:00 EST 2020

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.

Cell stem cell

Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J

300-07 was used in Cell Culture to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.

Thu Jul 02 00:00:00 EDT 2020

Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development.

Cell stem cell

Crosse EI,Gordon-Keylock S,Rybtsov S,Binagui-Casas A,Felchle H,Nnadi NC,Kirschner K,Chandra T,Tamagno S,Webb DJ,Rossi F,Anderson RA,Medvinsky A

300-07 was used in In vitro experiments to identify secreted signals underlying human HSC development, combining spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression profiling of sorted cell populations and single cells.

Thu Nov 05 00:00:00 EST 2020

Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells.

Cell stem cell

Jones CL,Stevens BM,Pollyea DA,Culp-Hill R,Reisz JA,Nemkov T,Gehrke S,Gamboni F,Krug A,Winters A,Pei S,Gustafson A,Ye H,Inguva A,Amaya M,Minhajuddin M,Abbott D,Becker MW,DeGregori J,Smith CA,D'Alessandro A,Jordan CT

300-07 was used in Tissue/organ culture to demonstrate that elevated nicotinamide metabolism is both the mechanistic basis for ven/aza resistance and a metabolic vulnerability of R/R LSCs.

Thu Nov 05 00:00:00 EST 2020

Bruton's tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis.

The Journal of clinical investigation

Dispenza MC,Krier-Burris RA,Chhiba KD,Undem BJ,Robida PA,Bochner BS

Tue Sep 01 00:00:00 EDT 2020

IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors.

The Journal of experimental medicine

Swann JW,Koneva LA,Regan-Komito D,Sansom SN,Powrie F,Griseri T

Mon Sep 07 00:00:00 EDT 2020

HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection.

The Journal of experimental medicine

Bodda C,Reinert LS,Fruhwürth S,Richardo T,Sun C,Zhang BC,Kalamvoki M,Pohlmann A,Mogensen TH,Bergström P,Agholme L,O'Hare P,Sodeik B,Gyrd-Hansen M,Zetterberg H,Paludan SR

Mon Jul 06 00:00:00 EDT 2020

Real-Time NMR Spectroscopy for Studying Metabolism.

Angewandte Chemie (International ed. in English)

Alshamleh I,Krause N,Richter C,Kurrle N,Serve H,Günther UL,Schwalbe H

Mon Feb 03 00:00:00 EST 2020

Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation.

Allergy

Le Floc'h A,Allinne J,Nagashima K,Scott G,Birchard D,Asrat S,Bai Y,Lim WK,Martin J,Huang T,Potocky TB,Kim JH,Rafique A,Papadopoulos NJ,Stahl N,Yancopoulos GD,Murphy AJ,Sleeman MA,Orengo JM

Fri May 01 00:00:00 EDT 2020

Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy.

EMBO molecular medicine

Di Matteo F,Pipicelli F,Kyrousi C,Tovecci I,Penna E,Crispino M,Chambery A,Russo R,Ayo-Martin AC,Giordano M,Hoffmann A,Ciusani E,Canafoglia L,Götz M,Di Giaimo R,Cappello S

Mon Jun 08 00:00:00 EDT 2020

Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production.

Developmental cell

Frame JM,Kubaczka C,Long TL,Esain V,Soto RA,Hachimi M,Jing R,Shwartz A,Goessling W,Daley GQ,North TE

300-07 was used in In vitro experiments to establish the inflammasome as a conserved metabolic sensor that expands HSPC production in vivo and in vitro.

Mon Oct 26 00:00:00 EDT 2020

Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells.

Proceedings of the National Academy of Sciences of the United States of America

Huang P,Zhao Y,Zhong J,Zhang X,Liu Q,Qiu X,Chen S,Yan H,Hillyer C,Mohandas N,Pan X,Xu X

Tue Jun 09 00:00:00 EDT 2020

Efficient and nontoxic biomolecule delivery to primary human hematopoietic stem cells using nanostraws.

Proceedings of the National Academy of Sciences of the United States of America

Schmiderer L,Subramaniam A,Žemaitis K,Bäckström A,Yudovich D,Soboleva S,Galeev R,Prinz CN,Larsson J,Hjort M

Tue Sep 01 00:00:00 EDT 2020

Acoustofluidic sonoporation for gene delivery to human hematopoietic stem and progenitor cells.

Proceedings of the National Academy of Sciences of the United States of America

Belling JN,Heidenreich LK,Tian Z,Mendoza AM,Chiou TT,Gong Y,Chen NY,Young TD,Wattanatorn N,Park JH,Scarabelli L,Chiang N,Takahashi J,Young SG,Stieg AZ,De Oliveira S,Huang TJ,Weiss PS,Jonas SJ

Tue May 19 00:00:00 EDT 2020

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.

Proceedings of the National Academy of Sciences of the United States of America

Qiao X,van der Zanden SY,Wander DPA,Borràs DM,Song JY,Li X,van Duikeren S,van Gils N,Rutten A,van Herwaarden T,van Tellingen O,Giacomelli E,Bellin M,Orlova V,Tertoolen LGJ,Gerhardt S,Akkermans JJ,Bakker JM,Zuur CL,Pang B,Smits AM,Mummery CL,Smit L,Arens R,Li J,Overkleeft HS,Neefjes J

Tue Jun 30 00:00:00 EDT 2020

Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway.

Proceedings of the National Academy of Sciences of the United States of America

Wang T,Medynets M,Johnson KR,Doucet-O'Hare TT,DiSanza B,Li W,Xu Y,Bagnell A,Tyagi R,Sampson K,Malik N,Steiner J,Hadegan A,Kowalak J,O'Malley J,Maric D,Nath A

Tue Jul 28 00:00:00 EDT 2020

ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells.

Oncogene

Redondo Monte E,Wilding A,Leubolt G,Kerbs P,Bagnoli JW,Hartmann L,Hiddemann W,Chen-Wichmann L,Krebs S,Blum H,Cusan M,Vick B,Jeremias I,Enard W,Theurich S,Wichmann C,Greif PA

Wed Apr 01 00:00:00 EDT 2020

Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood CD34⁺ cells via inhibition of senescence.

Stem cells translational medicine

Li X,Ma X,Chen Y,Peng D,Wang H,Chen S,Xiao Y,Li L,Zhou H,Cheng F,Gao Y,Chang J,Cheng T,Liu L

Tue Dec 01 00:00:00 EST 2020

Regulation of ABO blood group antigen expression by miR-331-3p and miR-1908-5p during hematopoietic stem cell differentiation.

Stem cells (Dayton, Ohio)

Kronstein-Wiedemann R,Nowakowska P,Milanov P,Gubbe K,Seifried E,Bugert P,Chavakis T,Tonn T

Thu Oct 01 00:00:00 EDT 2020

EDAG mediates Hsp70 nuclear localization in erythroblasts and rescues dyserythropoiesis in myelodysplastic syndrome.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Dong XM,Zhao K,Zheng WW,Xu CW,Zhang MJ,Yin RH,Gao R,Tang LJ,Liu JF,Chen H,Zhan YQ,Yu M,Ge CH,Gao HY,Li X,Luo T,Ning HM,Yang XM,Li CY

Mon Jun 01 00:00:00 EDT 2020

Good Manufacturing Practice-Grade of Megakaryocytes Produced by a Novel Ex Vivo Culturing Platform.

Clinical and translational science

Guan X,Wang L,Wang H,Wang H,Dai W,Jiang Y

Sun Nov 01 00:00:00 EDT 2020

MRGPRX2 activation as a rapid, high-throughput mechanistic-based approach for detecting peptide-mediated human mast cell degranulation liabilities.

Journal of immunotoxicology

Lafleur MA,Werner J,Fort M,Lobenhofer EK,Balazs M,Goyos A

300-07 was used in Sample Preparation (FC/FACS) to investigate the use of assessing MRGPRX2 activation in engineered cells in screening for mast cell degranulation for peptide-based therapeutics.

Tue Dec 01 00:00:00 EST 2020

Ex vivo editing of human hematopoietic stem cells for erythroid expression of therapeutic proteins.

Nature communications

Pavani G,Laurent M,Fabiano A,Cantelli E,Sakkal A,Corre G,Lenting PJ,Concordet JP,Toueille M,Miccio A,Amendola M

Wed Jul 29 00:00:00 EDT 2020

Targeted gene correction of human hematopoietic stem cells for the treatment of Wiskott - Aldrich Syndrome.

Nature communications

Rai R,Romito M,Rivers E,Turchiano G,Blattner G,Vetharoy W,Ladon D,Andrieux G,Zhang F,Zinicola M,Leon-Rico D,Santilli G,Thrasher AJ,Cavazza A

Wed Aug 12 00:00:00 EDT 2020

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.

Nature communications

Leonards K,Almosailleakh M,Tauchmann S,Bagger FO,Thirant C,Juge S,Bock T,Méreau H,Bezerra MF,Tzankov A,Ivanek R,Losson R,Peters AHFM,Mercher T,Schwaller J

Fri Jun 12 00:00:00 EDT 2020

Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation.

Communications biology

Yao Y,Yang J,Qin Q,Tang C,Li Z,Chen L,Li K,Ren C,Chen L,Rao S

Fri Dec 18 00:00:00 EST 2020

Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential.

Stem cell reports

Lange L,Hoffmann D,Schwarzer A,Ha TC,Philipp F,Lenz D,Morgan M,Schambach A

Tue Jan 14 00:00:00 EST 2020

Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.

Nature communications

Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ

300-07 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.

Fri Dec 04 00:00:00 EST 2020

Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.

Nature communications

Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ

300-07 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.

Fri Dec 04 00:00:00 EST 2020

Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression.

Cell reports

Rexach JE,Polioudakis D,Yin A,Swarup V,Chang TS,Nguyen T,Sarkar A,Chen L,Huang J,Lin LC,Seeley W,Trojanowski JQ,Malhotra D,Geschwind DH

300-07 was used in In vitro experiments to investigate gene analysis in neurodegenerative diseases.

Tue Nov 17 00:00:00 EST 2020

In vivo non-invasive staining-free visualization of dermal mast cells in healthy, allergy and mastocytosis humans using two-photon fluorescence lifetime imaging.

Scientific reports

Kröger M,Scheffel J,Nikolaev VV,Shirshin EA,Siebenhaar F,Schleusener J,Lademann J,Maurer M,Darvin ME

Thu Sep 10 00:00:00 EDT 2020

Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling.

Cell reports

Sinha S,Biswas M,Chatterjee SS,Kumar S,Sengupta A

300-07 was used in Cell Culture to study the molecular integration of developmental signaling with mesenchymal-stromal-cell (MSC) intrinsic chromatin regulation. To reveal a link illustrating epi-genomic feedforward control of bone morphogenic protein (BMP)/transforming growth factor β (TGF-β) signaling to transcriptional and cellular plasticity in the mesenchymal microenvironment and account for stromal-SWI/SNF in hematopoiesis.

Tue Apr 28 00:00:00 EDT 2020

Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia.

STAR protocols

Ryan SK,Jordan-Sciutto KL,Anderson SA

Fri Dec 18 00:00:00 EST 2020

DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes.

Cell death & disease

Johnson DC,Okondo MC,Orth EL,Rao SD,Huang HC,Ball DP,Bachovchin DA

Fri Aug 14 00:00:00 EDT 2020

Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141⁺ dendritic cells to activate naïve and memory WT1-specific CD8⁺ T cells.

Clinical & translational immunology

Pearson FE,Tullett KM,Leal-Rojas IM,Haigh OL,Masterman KA,Walpole C,Bridgeman JS,McLaren JE,Ladell K,Miners K,Llewellyn-Lacey S,Price DA,Tunger A,Schmitz M,Miles JJ,Lahoud MH,Radford KJ

Fri Apr 15 00:00:00 EDT 2022

Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype.

Nature communications

Thornton N,Karamatic Crew V,Tilley L,Green CA,Tay CL,Griffiths RE,Singleton BK,Spring F,Walser P,Alattar AG,Jones B,Laundy R,Storry JR,Möller M,Wall L,Charlewood R,Westhoff CM,Lomas-Francis C,Yahalom V,Feick U,Seltsam A,Mayer B,Olsson ML,Anstee DJ

Thu Jul 16 00:00:00 EDT 2020

Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy.

Scientific reports

Lázaro-Gorines R,López-Rodríguez JC,Benedé S,González M,Mayorga C,Vogel L,Martínez-Del-Pozo Á,Lacadena J,Villalba M

Thu Jul 23 00:00:00 EDT 2020

Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy.

Scientific reports

Lázaro-Gorines R,López-Rodríguez JC,Benedé S,González M,Mayorga C,Vogel L,Martínez-Del-Pozo Á,Lacadena J,Villalba M

Thu Jul 23 00:00:00 EDT 2020

Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy.

Scientific reports

Lázaro-Gorines R,López-Rodríguez JC,Benedé S,González M,Mayorga C,Vogel L,Martínez-Del-Pozo Á,Lacadena J,Villalba M

Thu Jul 23 00:00:00 EDT 2020

Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts.

Bio-protocol

Chen IP

300-07 was used in Cell Culture to study efficient differentiation of hiPSCs into osteoclasts using a three-stage protocol which does not require a co-culture system; induces EBs into mesoderm differentiation in a homogenous manner; uses less cytokines for differentiation; requires only a short time for osteoclast maturation and produces sufficient numbers of osteoclasts for subsequent molecular analyses.

Sun Dec 20 00:00:00 EST 2020

Mast Cell Activation Test (MAT).

Methods in molecular biology (Clifton, N.J.)

Bahri R,Bulfone-Paus S

300-07 was used in In vitro experiments to describe the use of the mast cell activation test (MAT) that makes use of human primary MCs generated from peripheral blood progenitors, sensitized overnight with patients' sera and activated with allergens.

Fri Feb 26 00:00:00 EST 2021

Increasing CRISPR Efficiency and Measuring Its Specificity in HSPCs Using a Clinically Relevant System.

Molecular therapy. Methods & clinical development

Shapiro J,Iancu O,Jacobi AM,McNeill MS,Turk R,Rettig GR,Amit I,Tovin-Recht A,Yakhini Z,Behlke MA,Hendel A

Fri Jun 12 00:00:00 EDT 2020

Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.

Nature communications

Araki R,Hoki Y,Suga T,Obara C,Sunayama M,Imadome K,Fujita M,Kamimura S,Nakamura M,Wakayama S,Nagy A,Wakayama T,Abe M

Fri Jan 10 00:00:00 EST 2020

Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-γ Responsive Pathway.

Cells

Haake K,Neehus AL,Buchegger T,Kühnel MP,Blank P,Philipp F,Oleaga-Quintas C,Schulz A,Grimley M,Goethe R,Jonigk D,Kalinke U,Boisson-Dupuis S,Casanova JL,Bustamante J,Lachmann N

300-07 was used in In vitro experiments to report a disease modeling platform to study the role of macrophages in patients with inborn errors of IFN-γ immunity.

Wed Feb 19 00:00:00 EST 2020

Human mast cells exhibit an individualized pattern of antimicrobial responses.

Immunity, inflammation and disease

Garcia-Rodriguez KM,Bahri R,Sattentau C,Roberts IS,Goenka A,Bulfone-Paus S

Mon Jun 01 00:00:00 EDT 2020

Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V.

Nature communications

Rai S,Tanaka H,Suzuki M,Espinoza JL,Kumode T,Tanimura A,Yokota T,Oritani K,Watanabe T,Kanakura Y,Matsumura I

Tue Aug 18 00:00:00 EDT 2020

Establishment of a Long-Term Co-culture Assay for Mesenchymal Stromal Cells and Hematopoietic Stem/Progenitors.

STAR protocols

Sinha S,Chakraborty S,Sengupta A

Fri Dec 18 00:00:00 EST 2020

The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.

Immunity

Mintz MA,Felce JH,Chou MY,Mayya V,Xu Y,Shui JW,An J,Li Z,Marson A,Okada T,Ware CF,Kronenberg M,Dustin ML,Cyster JG

Tue Aug 20 00:00:00 EDT 2019

Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos.

Immunity

Zeng Y,Liu C,Gong Y,Bai Z,Hou S,He J,Bian Z,Li Z,Ni Y,Yan J,Huang T,Shi H,Ma C,Chen X,Wang J,Bian L,Lan Y,Liu B,Hu H

Tue Nov 19 00:00:00 EST 2019

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Cancer cell

Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG

Mon Apr 15 00:00:00 EDT 2019

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Cancer cell

Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG

Mon Apr 15 00:00:00 EDT 2019

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.

Cancer cell

Labuhn M,Perkins K,Matzk S,Varghese L,Garnett C,Papaemmanuil E,Metzner M,Kennedy A,Amstislavskiy V,Risch T,Bhayadia R,Samulowski D,Hernandez DC,Stoilova B,Iotchkova V,Oppermann U,Scheer C,Yoshida K,Schwarzer A,Taub JW,Crispino JD,Weiss MJ,Hayashi Y,Taga T,Ito E,Ogawa S,Reinhardt D,Yaspo ML,Campbell PJ,Roberts I,Constantinescu SN,Vyas P,Heckl D,Klusmann JH

Mon Aug 12 00:00:00 EDT 2019

Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.

Nature immunology

Cella M,Gamini R,Sécca C,Collins PL,Zhao S,Peng V,Robinette ML,Schettini J,Zaitsev K,Gordon W,Bando JK,Yomogida K,Cortez V,Fronick C,Fulton R,Lin LL,Gilfillan S,Flavell RA,Shan L,Artyomov MN,Bowman M,Oltz EM,Jelinsky SA,Colonna M

300-07 was used in In vitro experiments to demonstrate that innate lymphoid cells (ILCs) undergo conversion from ILC3s into ILC1-like cells in human tissues in vivo, requiring tissue factors and Aiolos in the process.

Thu Aug 01 00:00:00 EDT 2019

PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia-initiating cells.

Blood

Hu T,Morita K,Hill MC,Jiang Y,Kitano A,Saito Y,Wang F,Mao X,Hoegenauer KA,Morishita K,Martin JF,Futreal PA,Takahashi K,Nakada D

Thu Aug 15 00:00:00 EDT 2019

Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.

Blood

Alvarado LJ,Huntsman HD,Cheng H,Townsley DM,Winkler T,Feng X,Dunbar CE,Young NS,Larochelle A

Thu May 09 00:00:00 EDT 2019

Germline mutations in the transcription factor IKZF5 cause thrombocytopenia.

Blood

Lentaigne C,Greene D,Sivapalaratnam S,Favier R,Seyres D,Thys C,Grassi L,Mangles S,Sibson K,Stubbs M,Burden F,Bordet JC,Armari-Alla C,Erber W,Farrow S,Gleadall N,Gomez K,Megy K,Papadia S,Penkett CJ,Sims MC,Stefanucci L,Stephens JC,Read RJ,Stirrups KE,Ouwehand WH,Laffan MA,Frontini M,Freson K,Turro E

Thu Dec 05 00:00:00 EST 2019

Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes.

Blood

Hsu J,Reilly A,Hayes BJ,Clough CA,Konnick EQ,Torok-Storb B,Gulsuner S,Wu D,Becker PS,Keel SB,Abkowitz JL,Doulatov S

Thu Jul 11 00:00:00 EDT 2019

Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.

Cell stem cell

Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Macabali MH,Gjertson D,Wang X,Galic Z,Kitchen SG,An DS,Hu-Lieskovan S,Kaplan-Lefko PJ,De Oliveira SN,Seet CS,Larson SM,Forman SJ,Heath JR,Zack JA,Crooks GM,Radu CG,Ribas A,Kohn DB,Witte ON,Yang L

300-07 was used in In vitro experiments to develop a proof-of-concept for hematopoietic stem cell-engineered invariant natural killer T (iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient's lifetime.

Thu Oct 03 00:00:00 EDT 2019

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.

The Journal of clinical investigation

Chan LC,Li CW,Xia W,Hsu JM,Lee HH,Cha JH,Wang HL,Yang WH,Yen EY,Chang WC,Zha Z,Lim SO,Lai YJ,Liu C,Liu J,Dong Q,Yang Y,Sun L,Wei Y,Nie L,Hsu JL,Li H,Ye Q,Hassan MM,Amin HM,Kaseb AO,Lin X,Wang SC,Hung MC

Mon Jul 15 00:00:00 EDT 2019

Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations.

Molecular cell

Gothe HJ,Bouwman BAM,Gusmao EG,Piccinno R,Petrosino G,Sayols S,Drechsel O,Minneker V,Josipovic N,Mizi A,Nielsen CF,Wagner EM,Takeda S,Sasanuma H,Hudson DF,Kindler T,Baranello L,Papantonis A,Crosetto N,Roukos V

300-07 was used in Cell Culture to propose that transcription and 3D chromosome folding jointly pose a threat to genomic stability and are key contributors to the occurrence of genome rearrangements that drive cancer.

Thu Jul 25 00:00:00 EDT 2019

Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response.

Science translational medicine

Sharon D,Cathelin S,Mirali S,Di Trani JM,Yanofsky DJ,Keon KA,Rubinstein JL,Schimmer AD,Ketela T,Chan SM

300-07 was used in Cell Culture to investigate if inactivation of genes involved in mitochondrial translation restores sensitivity to venetoclax in resistant acute myeloid leukemia cells.

Wed Oct 30 00:00:00 EDT 2019

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain.

Neuron

Green DP,Limjunyawong N,Gour N,Pundir P,Dong X

Wed Feb 06 00:00:00 EST 2019

Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR.

The Journal of experimental medicine

Deng M,Guo H,Tam JW,Johnson BM,Brickey WJ,New JS,Lenox A,Shi H,Golenbock DT,Koller BH,McKinnon KP,Beutler B,Ting JP

Mon Dec 02 00:00:00 EST 2019

Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity.

The Journal of allergy and clinical immunology

Klein O,Krier-Burris RA,Lazki-Hagenbach P,Gorzalczany Y,Mei Y,Ji P,Bochner BS,Sagi-Eisenberg R

300-07 was used in Cell Culture to identify mDia1 as a novel regulator of MC response that coordinates MC chemotaxis and secretion through its actin-nucleating activity.

Tue Oct 01 00:00:00 EDT 2019

NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia.

Leukemia

Lopez-Millan B,Sanchéz-Martínez D,Roca-Ho H,Gutiérrez-Agüera F,Molina O,Diaz de la Guardia R,Torres-Ruiz R,Fuster JL,Ballerini P,Suessbier U,Nombela-Arrieta C,Bueno C,Menéndez P

Mon Jul 01 00:00:00 EDT 2019

Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair.

Oncogene

Seoane M,Buhs S,Iglesias P,Strauss J,Puller AC,Müller J,Gerull H,Feldhaus S,Alawi M,Brandner JM,Eggert D,Du J,Thomale J,Wild PJ,Zimmermann M,Sternsdorf T,Schumacher U,Nollau P,Fisher DE,Horstmann MA

Wed May 01 00:00:00 EDT 2019

Enabling Large-Scale Ex Vivo Production of Megakaryocytes from CD34⁺ Cells Using Gas-Permeable Surfaces.

Stem cells translational medicine

Martinez AF,Miller WM

Mon Jul 01 00:00:00 EDT 2019

Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair.

Stem cells (Dayton, Ohio)

Lomova A,Clark DN,Campo-Fernandez B,Flores-Bjurström C,Kaufman ML,Fitz-Gibbon S,Wang X,Miyahira EY,Brown D,DeWitt MA,Corn JE,Hollis RP,Romero Z,Kohn DB

Fri Feb 01 00:00:00 EST 2019

Paracrine Factors Released by Osteoblasts Provide Strong Platelet Engraftment Properties.

Stem cells (Dayton, Ohio)

Abu-Khader A,Law KW,Jahan S,Manesia JK,Pasha R,Hovey O,Pineault N

Fri Mar 01 00:00:00 EST 2019

Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.

Journal of immunology (Baltimore, Md. : 1950)

Stephenson S,Care MA,Fan I,Zougman A,Westhead DR,Doody GM,Tooze RM

Fri Feb 15 00:00:00 EST 2019

Efficient gene correction of an aberrant splice site in β-thalassaemia iPSCs by CRISPR/Cas9 and single-strand oligodeoxynucleotides.

Journal of cellular and molecular medicine

Xiong Z,Xie Y,Yang Y,Xue Y,Wang D,Lin S,Chen D,Lu D,He L,Song B,Yang Y,Sun X

Sun Dec 01 00:00:00 EST 2019

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.

Cell reports

Aho ER,Wang J,Gogliotti RD,Howard GC,Phan J,Acharya P,Macdonald JD,Cheng K,Lorey SL,Lu B,Wenzel S,Foshage AM,Alvarado J,Wang F,Shaw JG,Zhao B,Weissmiller AM,Thomas LR,Vakoc CR,Hall MD,Hiebert SW,Liu Q,Stauffer SR,Fesik SW,Tansey WP

300-07 was used in Cell Culture to identify WIN site inhibitors and demonstrate that the WIN site links WDR5 to chromatin at a small cohort of loci, including a specific subset of ribosome protein genes.

Tue Mar 12 00:00:00 EDT 2019

Vitamin C-dependent lysine demethylase 6 (KDM6)-mediated demethylation promotes a chromatin state that supports the endothelial-to-hematopoietic transition.

The Journal of biological chemistry

Zhang T,Huang K,Zhu Y,Wang T,Shan Y,Long B,Li Y,Chen Q,Wang P,Zhao S,Li D,Wu C,Kang B,Gu J,Mai Y,Wang Q,Li J,Zhang Y,Liang Z,Guo L,Wu F,Su S,Wang J,Gao M,Zhong X,Liao B,Chen J,Zhang X,Shu X,Pei D,Nie J,Pan G

Fri Sep 13 00:00:00 EDT 2019

Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis.

Cell reports

Ludwig LS,Lareau CA,Bao EL,Nandakumar SK,Muus C,Ulirsch JC,Chowdhary K,Buenrostro JD,Mohandas N,An X,Aryee MJ,Regev A,Sankaran VG

300-07 was used in Cell Culture to apply deep transcriptomic and accessible chromatin profiling to characterize a faithful ex vivo human erythroid differentiation system from hematopoietic stem and progenitor cells.

Tue Jun 11 00:00:00 EDT 2019

Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index.

Scientific reports

Li Y,Thomas D,Deutzmann A,Majeti R,Felsher DW,Dill DL

Thu Nov 14 00:00:00 EST 2019

A comprehensive single cell transcriptional landscape of human hematopoietic progenitors.

Nature communications

Pellin D,Loperfido M,Baricordi C,Wolock SL,Montepeloso A,Weinberg OK,Biffi A,Klein AM,Biasco L

Mon Jun 03 00:00:00 EDT 2019

Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice.

Scientific reports

Radtke S,Görgens A,da Conceição Castro SV,Kordelas L,Köninger A,Dürig J,Möllmann M,Horn PA,Giebel B

Mon Sep 09 00:00:00 EDT 2019

A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer.

Cell death & disease

Mazzoldi EL,Pavan S,Pilotto G,Leone K,Pagotto A,Frezzini S,Nicoletto MO,Amadori A,Pastò A

Tue May 28 00:00:00 EDT 2019

Cytokine Selection of MSC Clones with Different Functionality.

Stem cell reports

Selich A,Ha TC,Morgan M,Falk CS,von Kaisenberg C,Schambach A,Rothe M

Tue Aug 13 00:00:00 EDT 2019

All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.

Cell death & disease

Nguyen CH,Bauer K,Hackl H,Schlerka A,Koller E,Hladik A,Stoiber D,Zuber J,Staber PB,Hoelbl-Kovacic A,Purton LE,Grebien F,Wieser R

Tue Dec 10 00:00:00 EST 2019

Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome.

Cell stem cell

Masiuk KE,Laborada J,Roncarolo MG,Hollis RP,Kohn DB

300-07 was used in Cell Culture to demonstrate preclinical efficacy for the treatment of IPEX patients by autologous HSC transplant and may provide valuable insights into new cell therapies for autoimmunity.

Thu Feb 07 00:00:00 EST 2019

Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.

Nature communications

Kusakabe M,Sun AC,Tyshchenko K,Wong R,Nanda A,Shanna C,Gusscott S,Chavez EA,Lorzadeh A,Zhu A,Hill A,Hung S,Brown S,Babaian A,Wang X,Holt RA,Steidl C,Karsan A,Humphries RK,Eaves CJ,Hirst M,Weng AP

Tue Jul 02 00:00:00 EDT 2019

UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells.

Scientific reports

Mesquitta WT,Wandsnider M,Kang H,Thomson J,Moskvin O,Suknuntha K,Slukvin II

Mon Apr 29 00:00:00 EDT 2019

Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo.

Stem cell reports

Easterbrook J,Rybtsov S,Gordon-Keylock S,Ivanovs A,Taoudi S,Anderson RA,Medvinsky A

Tue May 14 00:00:00 EDT 2019

Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.

Nature communications

Wang Y,Lu T,Sun G,Zheng Y,Yang S,Zhang H,Hao S,Liu Y,Ma S,Zhang H,Ru Y,Gao S,Yen K,Cheng H,Cheng T

Fri Dec 06 00:00:00 EST 2019

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.

Nature medicine

Johnson DC,Taabazuing CY,Okondo MC,Chui AJ,Rao SD,Brown FC,Reed C,Peguero E,de Stanchina E,Kentsis A,Bachovchin DA

300-07 was used in Cell Culture to identify an activator of CARD8 in human cells and indicate that its activation by small-molecule DPP8/9 inhibitors represents a new potential therapeutic strategy for AML.

Wed Aug 01 00:00:00 EDT 2018

Regulation of embryonic haematopoietic multipotency by EZH1.

Nature

Vo LT,Kinney MA,Liu X,Zhang Y,Barragan J,Sousa PM,Jha DK,Han A,Cesana M,Shao Z,North TE,Orkin SH,Doulatov S,Xu J,Daley GQ

Thu Jan 25 00:00:00 EST 2018

Identification of the Human Skeletal Stem Cell.

Cell

Chan CKF,Gulati GS,Sinha R,Tompkins JV,Lopez M,Carter AC,Ransom RC,Reinisch A,Wearda T,Murphy M,Brewer RE,Koepke LS,Marecic O,Manjunath A,Seo EY,Leavitt T,Lu WJ,Nguyen A,Conley SD,Salhotra A,Ambrosi TH,Borrelli MR,Siebel T,Chan K,Schallmoser K,Seita J,Sahoo D,Goodnough H,Bishop J,Gardner M,Majeti R,Wan DC,Goodman S,Weissman IL,Chang HY,Longaker MT

Thu Sep 20 00:00:00 EDT 2018

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.

Cell

Khajuria RK,Munschauer M,Ulirsch JC,Fiorini C,Ludwig LS,McFarland SK,Abdulhay NJ,Specht H,Keshishian H,Mani DR,Jovanovic M,Ellis SR,Fulco CP,Engreitz JM,Schütz S,Lian J,Gripp KW,Weinberg OK,Pinkus GS,Gehrke L,Regev A,Lander ES,Gazda HT,Lee WY,Panse VG,Carr SA,Sankaran VG

Thu Mar 22 00:00:00 EDT 2018

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.

Cell

Pulikkan JA,Hegde M,Ahmad HM,Belaghzal H,Illendula A,Yu J,O'Hagan K,Ou J,Muller-Tidow C,Wolfe SA,Zhu LJ,Dekker J,Bushweller JH,Castilla LH

300-07 was used in In vitro experiments to study the mechanism for the ways in which CBFβ-SMMHC drives leukemia maintenance and show that inhibitors targeting chromatin activity may prove effective in inv(16) leukemia therapy.

Thu Jun 28 00:00:00 EDT 2018

Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells.

Cell

Guzzi N,Cieśla M,Ngoc PCT,Lang S,Arora S,Dimitriou M,Pimková K,Sommarin MNE,Munita R,Lubas M,Lim Y,Okuyama K,Soneji S,Karlsson G,Hansson J,Jönsson G,Lund AH,Sigvardsson M,Hellström-Lindberg E,Hsieh AC,Bellodi C

Thu May 17 00:00:00 EDT 2018

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m⁶A/MYC/CEBPA Signaling.

Cell

Su R,Dong L,Li C,Nachtergaele S,Wunderlich M,Qing Y,Deng X,Wang Y,Weng X,Hu C,Yu M,Skibbe J,Dai Q,Zou D,Wu T,Yu K,Weng H,Huang H,Ferchen K,Qin X,Zhang B,Qi J,Sasaki AT,Plas DR,Bradner JE,Wei M,Marcucci G,Jiang X,Mulloy JC,Jin J,He C,Chen J

Thu Jan 11 00:00:00 EST 2018

Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

Cell

Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM

Thu Jan 25 00:00:00 EST 2018

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.

Cell

Kim MY,Yu KR,Kenderian SS,Ruella M,Chen S,Shin TH,Aljanahi AA,Schreeder D,Klichinsky M,Shestova O,Kozlowski MS,Cummins KD,Shan X,Shestov M,Bagg A,Morrissette JJD,Sekhri P,Lazzarotto CR,Calvo KR,Kuhns DB,Donahue RE,Behbehani GK,Tsai SQ,Dunbar CE,Gill S

Thu May 31 00:00:00 EDT 2018

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.

Cell

Thu May 31 00:00:00 EDT 2018

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Cancer cell

Jones CL,Stevens BM,D'Alessandro A,Reisz JA,Culp-Hill R,Nemkov T,Pei S,Khan N,Adane B,Ye H,Krug A,Reinhold D,Smith C,DeGregori J,Pollyea DA,Jordan CT

Mon Nov 12 00:00:00 EST 2018

Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation.

Blood

Li Y,Jin C,Bai H,Gao Y,Sun S,Chen L,Qin L,Liu PP,Cheng L,Wang QF

Thu Jan 11 00:00:00 EST 2018

IGF-1 facilitates thrombopoiesis primarily through Akt activation.

Blood

Chen S,Hu M,Shen M,Wang S,Wang C,Chen F,Tang Y,Wang X,Zeng H,Chen M,Gao J,Wang F,Su Y,Xu Y,Wang J

Thu Jul 12 00:00:00 EDT 2018

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.

Cell stem cell

Petrillo C,Thorne LG,Unali G,Schiroli G,Giordano AMS,Piras F,Cuccovillo I,Petit SJ,Ahsan F,Noursadeghi M,Clare S,Genovese P,Gentner B,Naldini L,Towers GJ,Kajaste-Rudnitski A

300-07 was used in In vitro experiments to report on the involvement of innate pathogen recognition molecules in immune blocks to gene correction in primary human hematopoietic stem cells.

Thu Dec 06 00:00:00 EST 2018

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.

Cell stem cell

Petrillo C,Thorne LG,Unali G,Schiroli G,Giordano AMS,Piras F,Cuccovillo I,Petit SJ,Ahsan F,Noursadeghi M,Clare S,Genovese P,Gentner B,Naldini L,Towers GJ,Kajaste-Rudnitski A

300-07 was used in In vitro experiments to report on the involvement of innate pathogen recognition molecules in immune blocks to gene correction in primary human hematopoietic stem cells.

Thu Dec 06 00:00:00 EST 2018

Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.

The Journal of clinical investigation

Chennupati V,Veiga DF,Maslowski KM,Andina N,Tardivel A,Yu EC,Stilinovic M,Simillion C,Duchosal MA,Quadroni M,Roberts I,Sankaran VG,MacDonald HR,Fasel N,Angelillo-Scherrer A,Schneider P,Hoang T,Allam R

Mon Apr 02 00:00:00 EDT 2018

Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.

The Journal of clinical investigation

Mon Apr 02 00:00:00 EDT 2018

JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling.

The Journal of clinical investigation

Zhang Y,Xia F,Liu X,Yu Z,Xie L,Liu L,Chen C,Jiang H,Hao X,He X,Zhang F,Gu H,Zhu J,Bai H,Zhang CC,Chen GQ,Zheng J

Tue May 01 00:00:00 EDT 2018

PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature.

The Journal of clinical investigation

Corrigan DJ,Luchsinger LL,Justino de Almeida M,Williams LJ,Strikoudis A,Snoeck HW

Wed Aug 01 00:00:00 EDT 2018

Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.

The Journal of experimental medicine

Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW

Mon Mar 05 00:00:00 EST 2018

Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.

The Journal of experimental medicine

Khalil S,Delehanty L,Grado S,Holy M,White Z,Freeman K,Kurita R,Nakamura Y,Bullock G,Goldfarb A

Mon Feb 05 00:00:00 EST 2018

The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.

The Journal of allergy and clinical immunology

Li Y,Liu B,Harmacek L,Long Z,Liang J,Lukin K,Leach SM,O'Connor B,Gerber AN,Hagman J,Roers A,Finkelman FD,Huang H

300-07 was used in Cell Culture to conclude that the transcription factors GATA2 and MITF regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.

Mon Oct 01 00:00:00 EDT 2018

Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies.

Clinical cancer research : an official journal of the American Association for Cancer Research

L'Italien L,Orozco O,Abrams T,Cantagallo L,Connor A,Desai J,Ebersbach H,Gelderblom H,Hoffmaster K,Lees E,Maacke H,Schleyer S,Skegro D,Lee-Hoeflich ST

300-07 was used in In vitro experiments to identifying potential mitigation strategies in hypersensitivity reactions.

Sun Jul 15 00:00:00 EDT 2018

A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.

Developmental cell

Böiers C,Richardson SE,Laycock E,Zriwil A,Turati VA,Brown J,Wray JP,Wang D,James C,Herrero J,Sitnicka E,Karlsson S,Smith AJH,Jacobsen SEW,Enver T

300-07 was used in Cell Culture to explore the link between embryonic B-myeloid fate restriction and ETV6-RUNX1 mutant acute B-lymphoblastic leukaemia development.

Mon Feb 05 00:00:00 EST 2018

Rhinovirus induces an anabolic reprogramming in host cell metabolism essential for viral replication.

Proceedings of the National Academy of Sciences of the United States of America

Gualdoni GA,Mayer KA,Kapsch AM,Kreuzberg K,Puck A,Kienzl P,Oberndorfer F,Frühwirth K,Winkler S,Blaas D,Zlabinger GJ,Stöckl J

Tue Jul 24 00:00:00 EDT 2018

Efficient generation of functional haploid spermatids from human germline stem cells by three-dimensional-induced system.

Cell death and differentiation

Sun M,Yuan Q,Niu M,Wang H,Wen L,Yao C,Hou J,Chen Z,Fu H,Zhou F,Li C,Gao S,Gao WQ,Li Z,He Z

Thu Mar 01 00:00:00 EST 2018

Rapid and Efficient Production of Human Functional Mast Cells through a Three-Dimensional Culture of Adipose Tissue-Derived Stromal Vascular Cells.

Journal of immunology (Baltimore, Md. : 1950)

Paupert J,Espinosa E,Cenac N,Robert V,Laharrague P,Evrard SM,Casteilla L,Lorsignol A,Cousin B

Sat Dec 15 00:00:00 EST 2018

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1.

Stem cell reports

Wang H,Liu C,Liu X,Wang M,Wu D,Gao J,Su P,Nakahata T,Zhou W,Xu Y,Shi L,Ma F,Zhou J

Tue Feb 13 00:00:00 EST 2018

Preserving self-renewal of porcine pluripotent stem cells in serum-free 3i culture condition and independent of LIF and b-FGF cytokines.

Cell death discovery

Ma Y,Yu T,Cai Y,Wang H

Sat Dec 01 00:00:00 EST 2018

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis.

Cell reports

Osorio FG,Rosendahl Huber A,Oka R,Verheul M,Patel SH,Hasaart K,de la Fonteijne L,Varela I,Camargo FD,van Boxtel R

300-07 was used in Sample Preparation (FC/FACS) to perform genomic analysis of the mutation accumulation of HSPCs.

Tue Nov 27 00:00:00 EST 2018

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.

Nature communications

Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II

Tue May 08 00:00:00 EDT 2018

Robust CRISPR/Cas9 Genome Editing of the HUDEP-2 Erythroid Precursor Line Using Plasmids and Single-Stranded Oligonucleotide Donors.

Methods and protocols

Moir-Meyer G,Cheong PL,Olijnik AA,Brown J,Knight S,King A,Kurita R,Nakamura Y,Gibbons RJ,Higgs DR,Buckle VJ,Babbs C

300-07 was used in Cell Culture to produce genetically modified lines in ~30 days and could also be used to generate knock-out and knock-in mutations.

Mon Jul 30 00:00:00 EDT 2018

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim.

Nature communications

Hu P,Nebreda AR,Hanenberg H,Kinnebrew GH,Ivan M,Yoder MC,Filippi MD,Broxmeyer HE,Kapur R

Wed Aug 29 00:00:00 EDT 2018

Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.

The Journal of biological chemistry

Seren S,Rashed Abouzaid M,Eulenberg-Gustavus C,Hirschfeld J,Nasr Soliman H,Jerke U,N'Guessan K,Dallet-Choisy S,Lesner A,Lauritzen C,Schacher B,Eickholz P,Nagy N,Szell M,Croix C,Viaud-Massuard MC,Al Farraj Aldosari A,Ragunatha S,Ibrahim Mostafa M,Giampieri F,Battino M,Cornillier H,Lorette G,Stephan JL,Goizet C,Pedersen J,Gauthier F,Jenne DE,Marchand-Adam S,Chapple IL,Kettritz R,Korkmaz B

Fri Aug 10 00:00:00 EDT 2018

Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.

Cell stem cell

Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP

300-07 was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.

Thu Nov 01 00:00:00 EDT 2018

Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity.

Cell reports

Balan S,Arnold-Schrauf C,Abbas A,Couespel N,Savoret J,Imperatore F,Villani AC,Vu Manh TP,Bhardwaj N,Dalod M

300-07 was used in Cell Culture to develop a dendritic cell (DC) differentiation method from human CD34+ precursors leading to high yields of plasmacytoid DCs and both types of conventional DCs.

Tue Aug 14 00:00:00 EDT 2018

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.

Nature communications

Laustsen A,Bak RO,Krapp C,Kjær L,Egedahl JH,Petersen CC,Pillai S,Tang HQ,Uldbjerg N,Porteus M,Roan NR,Nyegaard M,Denton PW,Jakobsen MR

Thu Aug 30 00:00:00 EDT 2018

Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons.

Scientific reports

DeRosa BA,El Hokayem J,Artimovich E,Garcia-Serje C,Phillips AW,Van Booven D,Nestor JE,Wang L,Cuccaro ML,Vance JM,Pericak-Vance MA,Cukier HN,Nestor MW,Dykxhoorn DM

Wed May 30 00:00:00 EDT 2018

Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes.

Nature communications

Stevens BM,Khan N,D'Alessandro A,Nemkov T,Winters A,Jones CL,Zhang W,Pollyea DA,Jordan CT

Wed Sep 12 00:00:00 EDT 2018

Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors.

Scientific reports

Eicke D,Baigger A,Schulze K,Latham SL,Halloin C,Zweigerdt R,Guzman CA,Blasczyk R,Figueiredo C

Thu Jul 05 00:00:00 EDT 2018

Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro.

Stem cell reports

Garcia-Alegria E,Menegatti S,Fadlullah MZH,Menendez P,Lacaud G,Kouskoff V

Tue Nov 13 00:00:00 EST 2018

Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23.

Nature communications

Xu Y,Sun Y,Shen H,Dai Y,Liu H,Li R,Zhang H,Wu L,Zhu X,Liu X

Mon Sep 24 00:00:00 EDT 2018

Pathological modelling of pigmentation disorders associated with Hutchinson-Gilford Progeria Syndrome (HGPS) revealed an impaired melanogenesis pathway in iPS-derived melanocytes.

Scientific reports

Lo Cicero A,Saidani M,Allouche J,Egesipe AL,Hoch L,Bruge C,Sigaudy S,De Sandre-Giovannoli A,Levy N,Baldeschi C,Nissan X

Thu Jun 14 00:00:00 EDT 2018

Reconstruction of complex single-cell trajectories using CellRouter.

Nature communications

Lummertz da Rocha E,Rowe RG,Lundin V,Malleshaiah M,Jha DK,Rambo CR,Li H,North TE,Collins JJ,Daley GQ

Thu Mar 01 00:00:00 EST 2018

Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation.

Scientific reports

Biechonski S,Olender L,Zipin-Roitman A,Yassin M,Aqaqe N,Marcu-Malina V,Rall-Scharpf M,Trottier M,Meyn MS,Wiesmüller L,Beider K,Raz Y,Grisaru D,Nagler A,Milyavsky M

Tue Apr 17 00:00:00 EDT 2018

Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells.

Stem cell reports

Tusa I,Cheloni G,Poteti M,Gozzini A,DeSouza NH,Shan Y,Deng X,Gray NS,Li S,Rovida E,Dello Sbarba P

Tue Oct 09 00:00:00 EDT 2018

iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.

Cell death & disease

Melguizo-Sanchis D,Xu Y,Taheem D,Yu M,Tilgner K,Barta T,Gassner K,Anyfantis G,Wan T,Elango R,Alharthi S,El-Harouni AA,Przyborski S,Adam S,Saretzki G,Samarasinghe S,Armstrong L,Lako M

Fri Jan 26 00:00:00 EST 2018

Leukaemic alterations of IKZF1 prime stemness and malignancy programs in human lymphocytes.

Cell death & disease

Li Z,Li SP,Li RY,Zhu H,Liu X,Guo XL,Mu LL,Cai JJ,Bai F,Chen GQ,Hong DL

Tue May 01 00:00:00 EDT 2018

Maintenance of human haematopoietic stem and progenitor cells in vitro using a chemical cocktail.

Cell discovery

Jiang M,Chen H,Lai S,Wang R,Qiu Y,Ye F,Fei L,Sun H,Xu Y,Jiang X,Zhou Z,Zhang T,Li Y,Xie J,Fang Q,Gale RP,Han X,Huang H,Guo G

Thu Oct 01 00:00:00 EDT 2020

c-Abl-TWIST1 Epigenetically Dysregulate Inflammatory Responses during Mycobacterial Infection by Co-Regulating Bone Morphogenesis Protein and miR27a.

Frontiers in immunology

Mahadik K,Prakhar P,Rajmani RS,Singh A,Balaji KN

300-07 was used in In vitro experiments to suggest molecular mechanisms of host pathways hijacked by mycobacteria and expand our understanding of c-Abl inhibitors in potentiating innate immune responses.

Thu Feb 28 00:00:00 EST 2019

Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia.

Nature communications

Shiozawa Y,Malcovati L,Gallì A,Sato-Otsubo A,Kataoka K,Sato Y,Watatani Y,Suzuki H,Yoshizato T,Yoshida K,Sanada M,Makishima H,Shiraishi Y,Chiba K,Hellström-Lindberg E,Miyano S,Ogawa S,Cazzola M

Fri Sep 07 00:00:00 EDT 2018

Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.

Stem cell reports

Brownjohn PW,Smith J,Solanki R,Lohmann E,Houlden H,Hardy J,Dietmann S,Livesey FJ

Tue Apr 10 00:00:00 EDT 2018

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.

Nature communications

Skucha A,Ebner J,Schmöllerl J,Roth M,Eder T,César-Razquin A,Stukalov A,Vittori S,Muhar M,Lu B,Aichinger M,Jude J,Müller AC,Győrffy B,Vakoc CR,Valent P,Bennett KL,Zuber J,Superti-Furga G,Grebien F

Fri May 18 00:00:00 EDT 2018

Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal.

Cell death & disease

Toofan P,Busch C,Morrison H,O'Brien S,Jørgensen H,Copland M,Wheadon H

Tue Sep 11 00:00:00 EDT 2018

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.

Stem cell reports

Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E

Tue Oct 09 00:00:00 EDT 2018

Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.

Nature communications

Balcerek J,Jiang J,Li Y,Jiang Q,Holdreith N,Singh B,Chandra V,Lv K,Ren JG,Rozenova K,Li W,Greenberg RA,Tong W

Tue Sep 25 00:00:00 EDT 2018

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.

Nature

Raffel S,Falcone M,Kneisel N,Hansson J,Wang W,Lutz C,Bullinger L,Poschet G,Nonnenmacher Y,Barnert A,Bahr C,Zeisberger P,Przybylla A,Sohn M,Tönjes M,Erez A,Adler L,Jensen P,Scholl C,Fröhling S,Cocciardi S,Wuchter P,Thiede C,Flörcken A,Westermann J,Ehninger G,Lichter P,Hiller K,Hell R,Herrmann C,Ho AD,Krijgsveld J,Radlwimmer B,Trumpp A

Thu Nov 16 00:00:00 EST 2017

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.

Cell

Kim AR,Ulirsch JC,Wilmes S,Unal E,Moraga I,Karakukcu M,Yuan D,Kazerounian S,Abdulhay NJ,King DS,Gupta N,Gabriel SB,Lander ES,Patiroglu T,Ozcan A,Ozdemir MA,Garcia KC,Piehler J,Gazda HT,Klein DE,Sankaran VG

300-07 was used in In vitro experiments to demonstrate how variation in a single cytokine can lead to biased downstream signaling and can thereby cause human disease.

Thu Mar 09 00:00:00 EST 2017

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.

Cell

Cimmino L,Dolgalev I,Wang Y,Yoshimi A,Martin GH,Wang J,Ng V,Xia B,Witkowski MT,Mitchell-Flack M,Grillo I,Bakogianni S,Ndiaye-Lobry D,Martín MT,Guillamot M,Banh RS,Xu M,Figueroa ME,Dickins RA,Abdel-Wahab O,Park CY,Tsirigos A,Neel BG,Aifantis I

Thu Sep 07 00:00:00 EDT 2017

CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.

Cell

Spencer DH,Russler-Germain DA,Ketkar S,Helton NM,Lamprecht TL,Fulton RS,Fronick CC,O'Laughlin M,Heath SE,Shinawi M,Westervelt P,Payton JE,Wartman LD,Welch JS,Wilson RK,Walter MJ,Link DC,DiPersio JF,Ley TJ

Thu Feb 23 00:00:00 EST 2017

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

Cancer cell

Chen Y,Anastassiadis K,Kranz A,Stewart AF,Arndt K,Waskow C,Yokoyama A,Jones K,Neff T,Lee Y,Ernst P

Mon Jun 12 00:00:00 EDT 2017

CCL2 is a KIT D816V-dependent modulator of the bone marrow microenvironment in systemic mastocytosis.

Blood

Greiner G,Witzeneder N,Berger A,Schmetterer K,Eisenwort G,Schiefer AI,Roos S,Popow-Kraupp T,Müllauer L,Zuber J,Sexl V,Kenner L,Sperr WR,Valent P,Mayerhofer M,Hoermann G

Thu Jan 19 00:00:00 EST 2017

Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia.

Blood

Serafin V,Capuzzo G,Milani G,Minuzzo SA,Pinazza M,Bortolozzi R,Bresolin S,Porcù E,Frasson C,Indraccolo S,Basso G,Accordi B

Thu Dec 21 00:00:00 EST 2017

Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.

Autophagy

Chen X,Clark J,Wunderlich M,Fan C,Davis A,Chen S,Guan JL,Mulloy JC,Kumar A,Zheng Y

300-07 was used in Cell Culture to uncover anti-leukemic effects of choloroquine being independent of autophagy which can be enhanced via vesicular exocytotis inhibition, and autophagy being an insignificant target of MA9-AML therapy.

Thu May 04 00:00:00 EDT 2017

Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Gao X,Lee HY,Li W,Platt RJ,Barrasa MI,Ma Q,Elmes RR,Rosenfeld MG,Lodish HF

Tue Sep 19 00:00:00 EDT 2017

Macrophages confer survival signals via CCR1-dependent translational MCL-1 induction in chronic lymphocytic leukemia.

Oncogene

van Attekum MHA,Terpstra S,Slinger E,von Lindern M,Moerland PD,Jongejan A,Kater AP,Eldering E

Thu Jun 29 00:00:00 EDT 2017

Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.

Stem cells translational medicine

Gori JL,Butler JM,Kunar B,Poulos MG,Ginsberg M,Nolan DJ,Norgaard ZK,Adair JE,Rafii S,Kiem HP

Wed Mar 01 00:00:00 EST 2017

Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.

Stem cells translational medicine

Gori JL,Butler JM,Kunar B,Poulos MG,Ginsberg M,Nolan DJ,Norgaard ZK,Adair JE,Rafii S,Kiem HP

Wed Mar 01 00:00:00 EST 2017

Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential.

Frontiers in oncology

Roy A,Libard S,Weishaupt H,Gustavsson I,Uhrbom L,Hesselager G,Swartling FJ,Pontén F,Alafuzoff I,Tchougounova E

300-07 was used in Cell Culture to indicate MCs' capability of modulating gene expression in BM cells and suggest that MCs can serve as a new target for drug development against metastases in the brain.

Sun Jan 03 00:00:00 EST 2021

CXCL12-CXCR4 Axis Is Required for Contact-Mediated Human B Lymphoid and Plasmacytoid Dendritic Cell Differentiation but Not T Lymphoid Generation.

Journal of immunology (Baltimore, Md. : 1950)

Minami H,Nagaharu K,Nakamori Y,Ohishi K,Shimojo N,Kageyama Y,Matsumoto T,Sugimoto Y,Tawara I,Masuya M,Miwa H,Katayama N

Sun Oct 01 00:00:00 EDT 2017

Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Akoto C,Davies DE,Swindle EJ

Wed Mar 01 00:00:00 EST 2017

Arachidonic acid and Docosahexanoic acid enhance platelet formation from human apheresis-derived CD34⁺ cells.

Cell cycle (Georgetown, Tex.)

Dhenge A,Limbkar K,Melinkeri S,Kale VP,Limaye L

300-07 was used in Cell Culture to examine the role of poly-unsaturated fatty acids in platelet production.

Fri May 19 00:00:00 EDT 2017

A potential bioactive hard-stock fat replacer comprised of a molecular gel.

Food science & nutrition

Rogers MA,Spagnuolo PA,Wang TM,Angka L

Mon May 01 00:00:00 EDT 2017

Evidence of In Vitro Preservation of Human Nephrogenesis at the Single-Cell Level.

Stem cell reports

Pode-Shakked N,Gershon R,Tam G,Omer D,Gnatek Y,Kanter I,Oriel S,Katz G,Harari-Steinberg O,Kalisky T,Dekel B

Tue Jul 11 00:00:00 EDT 2017

KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression.

Nature communications

Zhao H,Wang X,Yi P,Si Y,Tan P,He J,Yu S,Ren Y,Ma Y,Zhang J,Wang D,Wang F,Yu J

Fri Nov 10 00:00:00 EST 2017

The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age.

Nature communications

Hosokawa K,MacArthur BD,Ikushima YM,Toyama H,Masuhiro Y,Hanazawa S,Suda T,Arai F

Fri Oct 06 00:00:00 EDT 2017

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities.

Oncoimmunology

Van Caeneghem Y,De Munter S,Tieppo P,Goetgeluk G,Weening K,Verstichel G,Bonte S,Taghon T,Leclercq G,Kerre T,Debets R,Vermijlen D,Abken H,Vandekerckhove B

300-07 was used in Flow cytometry/Cell sorting to show that cord blood hematopoietic progenitor cells generate allogeneic CD3-antigen receptor (AR)+T cells which effectively eliminate malignant cells and limit graft versus host disease occurrence.

Tue Jan 12 00:00:00 EST 2021

Apoptotic resistance of human skin mast cells is mediated by Mcl-1.

Cell death discovery

Hazzan T,Eberle J,Worm M,Babina M

Tue Sep 29 00:00:00 EDT 2020

Downregulation of PARP1 transcription by promoter-associated E2F4-RBL2-HDAC1-BRM complex contributes to repression of pluripotency stem cell factors in human monocytes.

Scientific reports

Wiśnik E,Płoszaj T,Robaszkiewicz A

Fri Aug 25 00:00:00 EDT 2017

Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation.

Stem cell reports

Di Tullio A,Passaro D,Rouault-Pierre K,Purewal S,Bonnet D

Tue Jul 11 00:00:00 EDT 2017

Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.

Stem cell reports

Li Y,Brauer PM,Singh J,Xhiku S,Yoganathan K,Zúñiga-Pflücker JC,Anderson MK

Tue Sep 12 00:00:00 EDT 2017

CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells.

Cancer medicine

Ueshima C,Kataoka TR,Takei Y,Hirata M,Sugimoto A,Hirokawa M,Okayama Y,Blumberg RS,Haga H

Sat Apr 01 00:00:00 EDT 2017

High-throughput assessment of mechanical properties of stem cell derived red blood cells, toward cellular downstream processing.

Scientific reports

Guzniczak E,Mohammad Zadeh M,Dempsey F,Jimenez M,Bock H,Whyte G,Willoughby N,Bridle H

Tue Oct 31 00:00:00 EDT 2017

Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells.

Stem cell reports

Zeng J,Tang SY,Toh LL,Wang S

Tue Dec 12 00:00:00 EST 2017

Enforced GFI1 expression impedes human and murine leukemic cell growth.

Scientific reports

Hönes JM,Thivakaran A,Botezatu L,Patnana P,Castro SVDC,Al-Matary YS,Schütte J,Fischer KBI,Vassen L,Görgens A,Dührsen U,Giebel B,Khandanpour C

Thu Nov 16 00:00:00 EST 2017

Material Viscoelastic Properties Modulate the Mesenchymal Stem Cell Secretome for Applications in Hematopoietic Recovery.

ACS biomaterials science & engineering

Liu FD,Pishesha N,Poon Z,Kaushik T,Van Vliet KJ

300-07 was used in Cell Culture to leverage cell-material interactions in vitro to induce human bone marrow-derived MSCs to preferentially secrete factors that are beneficial to hematopoietic cell proliferation.

Mon Dec 11 00:00:00 EST 2017

Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.

Nature biotechnology

Stevens MM,Maire CL,Chou N,Murakami MA,Knoff DS,Kikuchi Y,Kimmerling RJ,Liu H,Haidar S,Calistri NL,Cermak N,Olcum S,Cordero NA,Idbaih A,Wen PY,Weinstock DM,Ligon KL,Manalis SR

300-07 was used in In vitro experiments to investigate assays for tumour cell therapeutic response.

Tue Nov 01 00:00:00 EDT 2016

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.

Cell

Puram RV,Kowalczyk MS,de Boer CG,Schneider RK,Miller PG,McConkey M,Tothova Z,Tejero H,Heckl D,Järås M,Chen MC,Li H,Tamayo A,Cowley GS,Rozenblatt-Rosen O,Al-Shahrour F,Regev A,Ebert BL

Thu Apr 07 00:00:00 EDT 2016

JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis.

Blood

Grisouard J,Li S,Kubovcakova L,Rao TN,Meyer SC,Lundberg P,Hao-Shen H,Romanet V,Murakami M,Radimerski T,Dirnhofer S,Skoda RC

Thu Aug 11 00:00:00 EDT 2016

JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis.

Blood

Grisouard J,Li S,Kubovcakova L,Rao TN,Meyer SC,Lundberg P,Hao-Shen H,Romanet V,Murakami M,Radimerski T,Dirnhofer S,Skoda RC

Thu Aug 11 00:00:00 EDT 2016

UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.

Blood

Samudio I,Rezvani K,Shaim H,Hofs E,Ngom M,Bu L,Liu G,Lee JT,Imren S,Lam V,Poon GF,Ghaedi M,Takei F,Humphries K,Jia W,Krystal G

Thu May 26 00:00:00 EDT 2016

Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.

Blood

Dahlin JS,Malinovschi A,Öhrvik H,Sandelin M,Janson C,Alving K,Hallgren J

Thu Jan 28 00:00:00 EST 2016

Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells.

Blood

Dhahri D,Sato-Kusubata K,Ohki-Koizumi M,Nishida C,Tashiro Y,Munakata S,Shimazu H,Salama Y,Eiamboonsert S,Nakauchi H,Hattori K,Heissig B

Thu Aug 25 00:00:00 EDT 2016

Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion.

Blood

Chesnais V,Renneville A,Toma A,Lambert J,Passet M,Dumont F,Chevret S,Lejeune J,Raimbault A,Stamatoullas A,Rose C,Beyne-Rauzy O,Delaunay J,Solary E,Fenaux P,Dreyfus F,Preudhomme C,Kosmider O,Fontenay M

Thu Feb 11 00:00:00 EST 2016

Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.

The Journal of clinical investigation

Brendel C,Guda S,Renella R,Bauer DE,Canver MC,Kim YJ,Heeney MM,Klatt D,Fogel J,Milsom MD,Orkin SH,Gregory RI,Williams DA

Mon Oct 03 00:00:00 EDT 2016

Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.

The Journal of clinical investigation

Gu H,Chen C,Hao X,Wang C,Zhang X,Li Z,Shao H,Zeng H,Yu Z,Xie L,Xia F,Zhang F,Liu X,Zhang Y,Jiang H,Zhu J,Wan J,Wang C,Weng W,Xie J,Tao M,Zhang CC,Liu J,Chen GQ,Zheng J

Thu Dec 01 00:00:00 EST 2016

Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia.

The Journal of clinical investigation

Jin Y,Zhou J,Xu F,Jin B,Cui L,Wang Y,Du X,Li J,Li P,Ren R,Pan J

Mon Oct 03 00:00:00 EDT 2016

Targeting MTHFD2 in acute myeloid leukemia.

The Journal of experimental medicine

Pikman Y,Puissant A,Alexe G,Furman A,Chen LM,Frumm SM,Ross L,Fenouille N,Bassil CF,Lewis CA,Ramos A,Gould J,Stone RM,DeAngelo DJ,Galinsky I,Clish CB,Kung AL,Hemann MT,Vander Heiden MG,Banerji V,Stegmaier K

Mon Jun 27 00:00:00 EDT 2016

Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.

The Journal of experimental medicine

Cheung KL,Jarrett R,Subramaniam S,Salimi M,Gutowska-Owsiak D,Chen YL,Hardman C,Xue L,Cerundolo V,Ogg G

Mon Oct 17 00:00:00 EDT 2016

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease.

The Journal of experimental medicine

Azad P,Zhao HW,Cabrales PJ,Ronen R,Zhou D,Poulsen O,Appenzeller O,Hsiao YH,Bafna V,Haddad GG

Mon Nov 14 00:00:00 EST 2016

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

Proceedings of the National Academy of Sciences of the United States of America

Gregory MA,D'Alessandro A,Alvarez-Calderon F,Kim J,Nemkov T,Adane B,Rozhok AI,Kumar A,Kumar V,Pollyea DA,Wempe MF,Jordan CT,Serkova NJ,Tan AC,Hansen KC,DeGregori J

Tue Oct 25 00:00:00 EDT 2016

Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos.

Proceedings of the National Academy of Sciences of the United States of America

Cohen MA,Wert KJ,Goldmann J,Markoulaki S,Buganim Y,Fu D,Jaenisch R

Tue Feb 09 00:00:00 EST 2016

Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis.

Stem cells (Dayton, Ohio)

Sweeney CL,Teng R,Wang H,Merling RK,Lee J,Choi U,Koontz S,Wright DG,Malech HL

Wed Jun 01 00:00:00 EDT 2016

Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis.

Stem cells (Dayton, Ohio)

Sweeney CL,Teng R,Wang H,Merling RK,Lee J,Choi U,Koontz S,Wright DG,Malech HL

Wed Jun 01 00:00:00 EDT 2016

Letter to the Editor: Production of Mature Healthy Hematopoietic Cells from Induced Pluripotent Stem Cells Derived from an AML Diagnostic Sample Containing the t(8;21) Translocation.

Stem cells (Dayton, Ohio)

Hoffmann D,Göhring G,Heuser M,Ganser A,Schambach A,Morgan MA

Tue Mar 01 00:00:00 EST 2016

Expansion of Th17 Cells by Human Mast Cells Is Driven by Inflammasome-Independent IL-1β.

Journal of immunology (Baltimore, Md. : 1950)

Suurmond J,Habets KL,Dorjée AL,Huizinga TW,Toes RE

Thu Dec 01 00:00:00 EST 2016

CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI.

Cell cycle (Georgetown, Tex.)

Moreno-Lorenzana D,Avilés-Vazquez S,Sandoval Esquivel MA,Alvarado-Moreno A,Ortiz-Navarrete V,Torres-Martínez H,Ayala-Sánchez M,Mayani H,Chavez-Gonzalez A

300-07 was used in Sample Preparation (FC/FACS) to analyze the cell cycle status, levels of several CDKIs and the subcellular localization of such molecules in different Chronic Myeloid Leukemia (CML) cell lines, as well as primary CD34(+)CD38(-)lin(-) LSC and HSC to understand the role of Cyclin Dependent Kinase Inhibitors in CML LSC permanence after tyrosine kinase inhibitor (TKI) treatment.

Mon May 02 00:00:00 EDT 2016

Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors.

Stem cell reports

Wen W,Zhang JP,Xu J,Su RJ,Neises A,Ji GZ,Yuan W,Cheng T,Zhang XB

Tue Jun 14 00:00:00 EDT 2016

GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.

Stem cell reports

D'Souza SS,Maufort J,Kumar A,Zhang J,Smuga-Otto K,Thomson JA,Slukvin II

Tue Feb 09 00:00:00 EST 2016

Ikaros Is a Negative Regulator of B1 Cell Development and Function.

The Journal of biological chemistry

Macias-Garcia A,Heizmann B,Sellars M,Marchal P,Dali H,Pasquali JL,Muller S,Kastner P,Chan S

Fri Apr 22 00:00:00 EDT 2016

Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency.

Scientific reports

Ikeda K,Ueda T,Yamasaki N,Nakata Y,Sera Y,Nagamachi A,Miyama T,Kobayashi H,Takubo K,Kanai A,Oda H,Wolff L,Honda Z,Ichinohe T,Matsubara A,Suda T,Inaba T,Honda H

Tue Jul 19 00:00:00 EDT 2016

Dual-SMAD Inhibition/WNT Activation-Based Methods to Induce Neural Crest and Derivatives from Human Pluripotent Stem Cells.

Methods in molecular biology (Clifton, N.J.)

Chambers SM,Mica Y,Lee G,Studer L,Tomishima MJ

300-07 was used in In vitro experiments to provide methods to direct NC into two different terminal fates: melanocytes and sensory neurons.

Mon May 16 00:00:00 EDT 2016

BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors.

Cell death & disease

Korfi K,Smith M,Swan J,Somervaille TC,Dhomen N,Marais R

Thu Apr 07 00:00:00 EDT 2016

Acetylation of C/EBPα inhibits its granulopoietic function.

Nature communications

Bararia D,Kwok HS,Welner RS,Numata A,Sárosi MB,Yang H,Wee S,Tschuri S,Ray D,Weigert O,Levantini E,Ebralidze AK,Gunaratne J,Tenen DG

Wed Mar 23 00:00:00 EDT 2016

Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation.

Stem cell reports

Saxena S,Rönn RE,Guibentif C,Moraghebi R,Woods NB

Tue May 10 00:00:00 EDT 2016

Human somatic cells subjected to genetic induction with six germ line-related factors display meiotic germ cell-like features.

Scientific reports

Medrano JV,Martínez-Arroyo AM,Míguez JM,Moreno I,Martínez S,Quiñonero A,Díaz-Gimeno P,Marqués-Marí AI,Pellicer A,Remohí J,Simón C

Tue Apr 26 00:00:00 EDT 2016

The Combination of CRISPR/Cas9 and iPSC Technologies in the Gene Therapy of Human β-thalassemia in Mice.

Scientific reports

Ou Z,Niu X,He W,Chen Y,Song B,Xian Y,Fan D,Tang D,Sun X

Thu Sep 01 00:00:00 EDT 2016

Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.

Nature communications

Adair JE,Waters T,Haworth KG,Kubek SP,Trobridge GD,Hocum JD,Heimfeld S,Kiem HP

Thu Oct 20 00:00:00 EDT 2016

Induction of Germ Cell-like Cells from Porcine Induced Pluripotent Stem Cells.

Scientific reports

Wang H,Xiang J,Zhang W,Li J,Wei Q,Zhong L,Ouyang H,Han J

Mon Jun 06 00:00:00 EDT 2016

Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.

Scientific reports

Chen JJ,Gao XT,Yang L,Fu W,Liang L,Li JC,Hu B,Sun ZJ,Huang SY,Zhang YZ,Liang YM,Qin HY,Han H

Wed May 18 00:00:00 EDT 2016

Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.

Scientific reports

Chen JJ,Gao XT,Yang L,Fu W,Liang L,Li JC,Hu B,Sun ZJ,Huang SY,Zhang YZ,Liang YM,Qin HY,Han H

Wed May 18 00:00:00 EDT 2016

ASXL1 plays an important role in erythropoiesis.

Scientific reports

Shi H,Yamamoto S,Sheng M,Bai J,Zhang P,Chen R,Chen S,Shi L,Abdel-Wahab O,Xu M,Zhou Y,Yang FC

Wed Jun 29 00:00:00 EDT 2016

Dissecting Stages of Human Kidney Development and Tumorigenesis with Surface Markers Affords Simple Prospective Purification of Nephron Stem Cells.

Scientific reports

Pode-Shakked N,Pleniceanu O,Gershon R,Shukrun R,Kanter I,Bucris E,Pode-Shakked B,Tam G,Tam H,Caspi R,Pri-Chen S,Vax E,Katz G,Omer D,Harari-Steinberg O,Kalisky T,Dekel B

Tue Mar 29 00:00:00 EDT 2016

Chromothriptic cure of WHIM syndrome.

Cell

McDermott DH,Gao JL,Liu Q,Siwicki M,Martens C,Jacobs P,Velez D,Yim E,Bryke CR,Hsu N,Dai Z,Marquesen MM,Stregevsky E,Kwatemaa N,Theobald N,Long Priel DA,Pittaluga S,Raffeld MA,Calvo KR,Maric I,Desmond R,Holmes KL,Kuhns DB,Balabanian K,Bachelerie F,Porcella SF,Malech HL,Murphy PM

Thu Feb 12 00:00:00 EST 2015

Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.

Cancer cell

Borkin D,He S,Miao H,Kempinska K,Pollock J,Chase J,Purohit T,Malik B,Zhao T,Wang J,Wen B,Zong H,Jones M,Danet-Desnoyers G,Guzman ML,Talpaz M,Bixby DL,Sun D,Hess JL,Muntean AG,Maillard I,Cierpicki T,Grembecka J

Mon Apr 13 00:00:00 EDT 2015

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.

Blood

Kinkel SA,Galeev R,Flensburg C,Keniry A,Breslin K,Gilan O,Lee S,Liu J,Chen K,Gearing LJ,Moore DL,Alexander WS,Dawson M,Majewski IJ,Oshlack A,Larsson J,Blewitt ME

Thu Mar 19 00:00:00 EDT 2015

Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.

Blood

Maude SL,Dolai S,Delgado-Martin C,Vincent T,Robbins A,Selvanathan A,Ryan T,Hall J,Wood AC,Tasian SK,Hunger SP,Loh ML,Mullighan CG,Wood BL,Hermiston ML,Grupp SA,Lock RB,Teachey DT

Thu Mar 12 00:00:00 EDT 2015

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells.

Blood

Hoban MD,Cost GJ,Mendel MC,Romero Z,Kaufman ML,Joglekar AV,Ho M,Lumaquin D,Gray D,Lill GR,Cooper AR,Urbinati F,Senadheera S,Zhu A,Liu PQ,Paschon DE,Zhang L,Rebar EJ,Wilber A,Wang X,Gregory PD,Holmes MC,Reik A,Hollis RP,Kohn DB

Thu Apr 23 00:00:00 EDT 2015

Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.

Blood

Jang IH,Lu YF,Zhao L,Wenzel PL,Kume T,Datta SM,Arora N,Guiu J,Lagha M,Kim PG,Do EK,Kim JH,Schlaeger TM,Zon LI,Bigas A,Burns CE,Daley GQ

Thu Feb 26 00:00:00 EST 2015

A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor.

Blood

Belay E,Miller CP,Kortum AN,Torok-Storb B,Blau CA,Emery DW

Thu Feb 05 00:00:00 EST 2015

Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.

Blood

Sinha S,Thomas D,Yu L,Gentles AJ,Jung N,Corces-Zimmerman MR,Chan SM,Reinisch A,Feinberg AP,Dill DL,Majeti R

Thu Jan 08 00:00:00 EST 2015

MLL leukemia induction by genome editing of human CD34+ hematopoietic cells.

Blood

Buechele C,Breese EH,Schneidawind D,Lin CH,Jeong J,Duque-Afonso J,Wong SH,Smith KS,Negrin RS,Porteus M,Cleary ML

Thu Oct 01 00:00:00 EDT 2015

Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis.

Blood

Schwartz C,Willebrand R,Huber S,Rupec RA,Wu D,Locksley R,Voehringer D

Thu Jun 18 00:00:00 EDT 2015

Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia.

The Journal of clinical investigation

Meldi K,Qin T,Buchi F,Droin N,Sotzen J,Micol JB,Selimoglu-Buet D,Masala E,Allione B,Gioia D,Poloni A,Lunghi M,Solary E,Abdel-Wahab O,Santini V,Figueroa ME

Fri May 01 00:00:00 EDT 2015

Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.

The Journal of clinical investigation

Nayak RC,Trump LR,Aronow BJ,Myers K,Mehta P,Kalfa T,Wellendorf AM,Valencia CA,Paddison PJ,Horwitz MS,Grimes HL,Lutzko C,Cancelas JA

Mon Aug 03 00:00:00 EDT 2015

A single glycan on IgE is indispensable for initiation of anaphylaxis.

The Journal of experimental medicine

Shade KT,Platzer B,Washburn N,Mani V,Bartsch YC,Conroy M,Pagan JD,Bosques C,Mempel TR,Fiebiger E,Anthony RM

Mon Apr 06 00:00:00 EDT 2015

Circulating precursors of human CD1c+ and CD141+ dendritic cells.

The Journal of experimental medicine

Breton G,Lee J,Zhou YJ,Schreiber JJ,Keler T,Puhr S,Anandasabapathy N,Schlesinger S,Caskey M,Liu K,Nussenzweig MC

Mon Mar 09 00:00:00 EDT 2015

CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo.

The Journal of experimental medicine

Mende N,Kuchen EE,Lesche M,Grinenko T,Kokkaliaris KD,Hanenberg H,Lindemann D,Dahl A,Platz A,Höfer T,Calegari F,Waskow C

Mon Jul 27 00:00:00 EDT 2015

Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow.

The Journal of experimental medicine

Lee J,Breton G,Oliveira TY,Zhou YJ,Aljoufi A,Puhr S,Cameron MJ,Sékaly RP,Nussenzweig MC,Liu K

Mon Mar 09 00:00:00 EDT 2015

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.

Proceedings of the National Academy of Sciences of the United States of America

Yin J,Leavenworth JW,Li Y,Luo Q,Xie H,Liu X,Huang S,Yan H,Fu Z,Zhang LY,Zhang L,Hao J,Wu X,Deng X,Roberts CW,Orkin SH,Cantor H,Wang X

Tue Dec 29 00:00:00 EST 2015

Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.

British journal of haematology

Sjögren SE,Siva K,Soneji S,George AJ,Winkler M,Jaako P,Wlodarski M,Karlsson S,Hannan RD,Flygare J

Sun Nov 01 00:00:00 EDT 2015

The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.

Stem cells (Dayton, Ohio)

Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS

Wed Apr 01 00:00:00 EDT 2015

The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.

Stem cells (Dayton, Ohio)

Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS

Wed Apr 01 00:00:00 EDT 2015

Molecular signature of erythroblast enucleation in human embryonic stem cells.

Stem cells (Dayton, Ohio)

Rouzbeh S,Kobari L,Cambot M,Mazurier C,Hebert N,Faussat AM,Durand C,Douay L,Lapillonne H

Sat Aug 01 00:00:00 EDT 2015

The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production.

Journal of immunology (Baltimore, Md. : 1950)

Pundir P,MacDonald CA,Kulka M

Tue Sep 15 00:00:00 EDT 2015

Induction of the proapoptotic tumor suppressor gene Cell Adhesion Molecule 1 by chemotherapeutic agents is repressed in therapy resistant acute myeloid leukemia.

Molecular carcinogenesis

Fisser MC,Rommer A,Steinleitner K,Heller G,Herbst F,Wiese M,Glimm H,Sill H,Wieser R

Tue Dec 01 00:00:00 EST 2015

PRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic stem and progenitor cells.

Scientific reports

Varagnolo L,Lin Q,Obier N,Plass C,Dietl J,Zenke M,Claus R,Müller AM

Wed Jul 22 00:00:00 EDT 2015

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.

Stem cell reports

Garate Z,Quintana-Bustamante O,Crane AM,Olivier E,Poirot L,Galetto R,Kosinski P,Hill C,Kung C,Agirre X,Orman I,Cerrato L,Alberquilla O,Rodriguez-Fornes F,Fusaki N,Garcia-Sanchez F,Maia TM,Ribeiro ML,Sevilla J,Prosper F,Jin S,Mountford J,Guenechea G,Gouble A,Bueren JA,Davis BR,Segovia JC

Tue Dec 08 00:00:00 EST 2015

Opportunistic pathogen Candida albicans elicits a temporal response in primary human mast cells.

Scientific reports

Lopes JP,Stylianou M,Nilsson G,Urban CF

Mon Jul 20 00:00:00 EDT 2015

Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy.

Molecular therapy. Methods & clinical development

Wielgosz MM,Kim YS,Carney GG,Zhan J,Reddivari M,Coop T,Heath RJ,Brown SA,Nienhuis AW

300-07 was used in In vitro experiments to show that the producer cell line and the specific monoclonal antibody will facilitate the development of a clinical protocol for gene transfer into WAS protein deficient stem cells.

Mon Jun 08 00:00:00 EDT 2015

Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.

Scientific reports

Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J

Mon Oct 12 00:00:00 EDT 2015

Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.

Scientific reports

Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J

Mon Oct 12 00:00:00 EDT 2015

Fancd2 is required for nuclear retention of Foxo3a in hematopoietic stem cell maintenance.

The Journal of biological chemistry

Li X,Li J,Wilson A,Sipple J,Schick J,Pang Q

Fri Jan 30 00:00:00 EST 2015

Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles.

Molecular therapy. Methods & clinical development

Prel A,Caval V,Gayon R,Ravassard P,Duthoit C,Payen E,Maouche-Chretien L,Creneguy A,Nguyen TH,Martin N,Piver E,Sevrain R,Lamouroux L,Leboulch P,Deschaseaux F,Bouillé P,Sensébé L,Pagès JC

Tue Nov 03 00:00:00 EST 2015

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation.

Nature communications

Cohen ES,Scott IC,Majithiya JB,Rapley L,Kemp BP,England E,Rees DG,Overed-Sayer CL,Woods J,Bond NJ,Veyssier CS,Embrey KJ,Sims DA,Snaith MR,Vousden KA,Strain MD,Chan DT,Carmen S,Huntington CE,Flavell L,Xu J,Popovic B,Brightling CE,Vaughan TJ,Butler R,Lowe DC,Higazi DR,Corkill DJ,May RD,Sleeman MA,Mustelin T

Mon Sep 14 00:00:00 EDT 2015

Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.

Scientific reports

Xie XQ,Yang P,Zhang Y,Zhang P,Wang L,Ding Y,Yang M,Tong Q,Cheng H,Ji Q,McGuire T,Yuan W,Cheng T,Gao Y

Fri Dec 18 00:00:00 EST 2015

AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages.

Cell death & disease

Six E,Lagresle-Peyrou C,Susini S,De Chappedelaine C,Sigrist N,Sadek H,Chouteau M,Cagnard N,Fontenay M,Hermine O,Chomienne C,Reynier P,Fischer A,André-Schmutz I,Gueguen N,Cavazzana M

Thu Aug 13 00:00:00 EDT 2015

Rh D blood group conversion using transcription activator-like effector nucleases.

Nature communications

Kim YH,Kim HO,Baek EJ,Kurita R,Cha HJ,Nakamura Y,Kim H

Tue Jun 16 00:00:00 EDT 2015

Targeted genome editing in human repopulating haematopoietic stem cells.

Nature

Genovese P,Schiroli G,Escobar G,Tomaso TD,Firrito C,Calabria A,Moi D,Mazzieri R,Bonini C,Holmes MC,Gregory PD,van der Burg M,Gentner B,Montini E,Lombardo A,Naldini L

Thu Jun 12 00:00:00 EDT 2014

Chemically defined generation of human cardiomyocytes.

Nature methods

Burridge PW,Matsa E,Shukla P,Lin ZC,Churko JM,Ebert AD,Lan F,Diecke S,Huber B,Mordwinkin NM,Plews JR,Abilez OJ,Cui B,Gold JD,Wu JC

Fri Aug 01 00:00:00 EDT 2014

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.

Blood

Bots M,Verbrugge I,Martin BP,Salmon JM,Ghisi M,Baker A,Stanley K,Shortt J,Ossenkoppele GJ,Zuber J,Rappaport AR,Atadja P,Lowe SW,Johnstone RW

Thu Feb 27 00:00:00 EST 2014

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.

Blood

Bots M,Verbrugge I,Martin BP,Salmon JM,Ghisi M,Baker A,Stanley K,Shortt J,Ossenkoppele GJ,Zuber J,Rappaport AR,Atadja P,Lowe SW,Johnstone RW

Thu Feb 27 00:00:00 EST 2014

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.

Blood

Gough DJ,Marié IJ,Lobry C,Aifantis I,Levy DE

Thu Oct 02 00:00:00 EDT 2014

Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells.

Blood

Nievergall E,Ramshaw HS,Yong AS,Biondo M,Busfield SJ,Vairo G,Lopez AF,Hughes TP,White DL,Hiwase DK

Thu Feb 20 00:00:00 EST 2014

Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells.

Blood

Wang CX,Sather BD,Wang X,Adair J,Khan I,Singh S,Lang S,Adams A,Curinga G,Kiem HP,Miao CH,Rawlings DJ,Torbett BE

Thu Aug 07 00:00:00 EDT 2014

Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes.

Blood

Lee WC,Malleret B,Lau YL,Mauduit M,Fong MY,Cho JS,Suwanarusk R,Zhang R,Albrecht L,Costa FT,Preiser P,McGready R,Renia L,Nosten F,Russell B

Thu May 01 00:00:00 EDT 2014

Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations.

Blood

Traer E,Javidi-Sharifi N,Agarwal A,Dunlap J,English I,Martinez J,Tyner JW,Wong M,Druker BJ

Thu Mar 06 00:00:00 EST 2014

The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells.

Blood

Yang Z,Augustin J,Chang C,Hu J,Shah K,Chang CW,Townes T,Jiang H

Thu Sep 25 00:00:00 EDT 2014

Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.

The Journal of clinical investigation

Velu CS,Chaubey A,Phelan JD,Horman SR,Wunderlich M,Guzman ML,Jegga AG,Zeleznik-Le NJ,Chen J,Mulloy JC,Cancelas JA,Jordan CT,Aronow BJ,Marcucci G,Bhat B,Gebelein B,Grimes HL

Wed Jan 01 00:00:00 EST 2014

RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.

The Journal of experimental medicine

Verma R,Su S,McCrann DJ,Green JM,Leu K,Young PR,Schatz PJ,Silva JC,Stokes MP,Wojchowski DM

Mon Aug 25 00:00:00 EDT 2014

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.

The Journal of experimental medicine

Berres ML,Lim KP,Peters T,Price J,Takizawa H,Salmon H,Idoyaga J,Ruzo A,Lupo PJ,Hicks MJ,Shih A,Simko SJ,Abhyankar H,Chakraborty R,Leboeuf M,Beltrão M,Lira SA,Heym KM,Bigley V,Collin M,Manz MG,McClain K,Merad M,Allen CE

Mon Apr 07 00:00:00 EDT 2014

Quantitative and stoichiometric analysis of the microRNA content of exosomes.

Proceedings of the National Academy of Sciences of the United States of America

Chevillet JR,Kang Q,Ruf IK,Briggs HA,Vojtech LN,Hughes SM,Cheng HH,Arroyo JD,Meredith EK,Gallichotte EN,Pogosova-Agadjanyan EL,Morrissey C,Stirewalt DL,Hladik F,Yu EY,Higano CS,Tewari M

Tue Oct 14 00:00:00 EDT 2014

IL-33/ST2 axis promotes mast cell survival via BCLXL.

Proceedings of the National Academy of Sciences of the United States of America

Wang JX,Kaieda S,Ameri S,Fishgal N,Dwyer D,Dellinger A,Kepley CL,Gurish MF,Nigrovic PA

Tue Jul 15 00:00:00 EDT 2014

The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia.

Cell death and differentiation

Gong JN,Yu J,Lin HS,Zhang XH,Yin XL,Xiao Z,Wang F,Wang XS,Su R,Shen C,Zhao HL,Ma YN,Zhang JW

Wed Jan 01 00:00:00 EST 2014

Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model.

Molecular therapy. Nucleic acids

Haemmerle R,Phaltane R,Rothe M,Schröder S,Schambach A,Moritz T,Modlich U

Tue Oct 07 00:00:00 EDT 2014

Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells.

Blood cancer journal

Askmyr M,Ågerstam H,Lilljebjörn H,Hansen N,Karlsson C,von Palffy S,Landberg N,Högberg C,Lassen C,Rissler M,Richter J,Ehinger M,Järås M,Fioretos T

Fri Dec 12 00:00:00 EST 2014

Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells.

Journal of lipid research

Dichlberger A,Schlager S,Maaninka K,Schneider WJ,Kovanen PT

Mon Dec 01 00:00:00 EST 2014

EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300.

Stem cells (Dayton, Ohio)

Zheng WW,Dong XM,Yin RH,Xu FF,Ning HM,Zhang MJ,Xu CW,Yang Y,Ding YL,Wang ZD,Zhao WB,Tang LJ,Chen H,Wang XH,Zhan YQ,Yu M,Ge CH,Li CY,Yang XM

Fri Aug 01 00:00:00 EDT 2014

Expression of chimeric receptor CD4ζ by natural killer cells derived from human pluripotent stem cells improves in vitro activity but does not enhance suppression of HIV infection in vivo.

Stem cells (Dayton, Ohio)

Ni Z,Knorr DA,Bendzick L,Allred J,Kaufman DS

Tue Apr 01 00:00:00 EDT 2014

Generation of functional, antigen-specific CD8+ human T cells from cord blood stem cells using exogenous Notch and tetramer-TCR signaling.

Stem cells (Dayton, Ohio)

Fernandez I,Ooi TP,Roy K

Wed Jan 01 00:00:00 EST 2014

Conversion of human fibroblasts into monocyte-like progenitor cells.

Stem cells (Dayton, Ohio)

Pulecio J,Nivet E,Sancho-Martinez I,Vitaloni M,Guenechea G,Xia Y,Kurian L,Dubova I,Bueren J,Laricchia-Robbio L,Belmonte JCI

Sat Nov 01 00:00:00 EDT 2014

Conversion of human fibroblasts into monocyte-like progenitor cells.

Stem cells (Dayton, Ohio)

Pulecio J,Nivet E,Sancho-Martinez I,Vitaloni M,Guenechea G,Xia Y,Kurian L,Dubova I,Bueren J,Laricchia-Robbio L,Belmonte JCI

Sat Nov 01 00:00:00 EDT 2014

Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming.

Stem cells (Dayton, Ohio)

Zdzieblo D,Li X,Lin Q,Zenke M,Illich DJ,Becker M,Müller AM

Mon Dec 01 00:00:00 EST 2014

Critical Roles for PU.1, GATA1, and GATA2 in the expression of human FcεRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2.

Journal of immunology (Baltimore, Md. : 1950)

Inage E,Kasakura K,Yashiro T,Suzuki R,Baba Y,Nakano N,Hara M,Tanabe A,Oboki K,Matsumoto K,Saito H,Niyonsaba F,Ohtsuka Y,Ogawa H,Okumura K,Shimizu T,Nishiyama C

Tue Apr 15 00:00:00 EDT 2014

Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation.

Journal of immunology (Baltimore, Md. : 1950)

Smrz D,Cruse G,Beaven MA,Kirshenbaum A,Metcalfe DD,Gilfillan AM

Mon Dec 15 00:00:00 EST 2014

Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Balan S,Ollion V,Colletti N,Chelbi R,Montanana-Sanchis F,Liu H,Vu Manh TP,Sanchez C,Savoret J,Perrot I,Doffin AC,Fossum E,Bechlian D,Chabannon C,Bogen B,Asselin-Paturel C,Shaw M,Soos T,Caux C,Valladeau-Guilemond J,Dalod M

Fri Aug 15 00:00:00 EDT 2014

3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase, promotes erythroid differentiation.

The Journal of biological chemistry

Fujiwara T,Saitoh H,Inoue A,Kobayashi M,Okitsu Y,Katsuoka Y,Fukuhara N,Onishi Y,Ishizawa K,Ichinohasama R,Harigae H

Fri Mar 21 00:00:00 EDT 2014

Regulation of Fc∈RI signaling in mast cells by G protein-coupled receptor kinase 2 and its RH domain.

The Journal of biological chemistry

Subramanian H,Gupta K,Parameswaran N,Ali H

Fri Jul 25 00:00:00 EDT 2014

Derivation of novel human ground state naive pluripotent stem cells.

Nature

Gafni O,Weinberger L,Mansour AA,Manor YS,Chomsky E,Ben-Yosef D,Kalma Y,Viukov S,Maza I,Zviran A,Rais Y,Shipony Z,Mukamel Z,Krupalnik V,Zerbib M,Geula S,Caspi I,Schneir D,Shwartz T,Gilad S,Amann-Zalcenstein D,Benjamin S,Amit I,Tanay A,Massarwa R,Novershtern N,Hanna JH

Thu Dec 12 00:00:00 EST 2013

Derivation of novel human ground state naive pluripotent stem cells.

Nature

Thu Dec 12 00:00:00 EST 2013

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability.

Cell

King B,Trimarchi T,Reavie L,Xu L,Mullenders J,Ntziachristos P,Aranda-Orgilles B,Perez-Garcia A,Shi J,Vakoc C,Sandy P,Shen SS,Ferrando A,Aifantis I

Thu Jun 20 00:00:00 EDT 2013

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.

Blood

Mace EM,Hsu AP,Monaco-Shawver L,Makedonas G,Rosen JB,Dropulic L,Cohen JI,Frenkel EP,Bagwell JC,Sullivan JL,Biron CA,Spalding C,Zerbe CS,Uzel G,Holland SM,Orange JS

Thu Apr 04 00:00:00 EDT 2013

RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.

Blood

Harada Y,Inoue D,Ding Y,Imagawa J,Doki N,Matsui H,Yahata T,Matsushita H,Ando K,Sashida G,Iwama A,Kitamura T,Harada H

Thu Apr 25 00:00:00 EDT 2013

CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age.

Blood

Gekas C,Graf T

Thu May 30 00:00:00 EDT 2013

SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.

Blood

Kung Sutherland MS,Walter RB,Jeffrey SC,Burke PJ,Yu C,Kostner H,Stone I,Ryan MC,Sussman D,Lyon RP,Zeng W,Harrington KH,Klussman K,Westendorf L,Meyer D,Bernstein ID,Senter PD,Benjamin DR,Drachman JG,McEarchern JA

Thu Aug 22 00:00:00 EDT 2013

Transgene-free iPSCs generated from small volume peripheral blood nonmobilized CD34+ cells.

Blood

Merling RK,Sweeney CL,Choi U,De Ravin SS,Myers TG,Otaizo-Carrasquero F,Pan J,Linton G,Chen L,Koontz S,Theobald NL,Malech HL

Thu Apr 04 00:00:00 EDT 2013

Role of SOX17 in hematopoietic development from human embryonic stem cells.

Blood

Nakajima-Takagi Y,Osawa M,Oshima M,Takagi H,Miyagi S,Endoh M,Endo TA,Takayama N,Eto K,Toyoda T,Koseki H,Nakauchi H,Iwama A

Thu Jan 17 00:00:00 EST 2013

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells.

Blood

Bolton-Gillespie E,Schemionek M,Klein HU,Flis S,Hoser G,Lange T,Nieborowska-Skorska M,Maier J,Kerstiens L,Koptyra M,Müller MC,Modi H,Stoklosa T,Seferynska I,Bhatia R,Holyoake TL,Koschmieder S,Skorski T

Thu May 16 00:00:00 EDT 2013

Identification of the chemokine CCL28 as a growth and survival factor for human hematopoietic stem and progenitor cells.

Blood

Karlsson C,Baudet A,Miharada N,Soneji S,Gupta R,Magnusson M,Enver T,Karlsson G,Larsson J

Thu May 09 00:00:00 EDT 2013

PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway.

Blood

Kauskot A,Vandenbriele C,Louwette S,Gijsbers R,Tousseyn T,Freson K,Verhamme P,Hoylaerts MF

Thu Jun 27 00:00:00 EDT 2013

Genomic impact of transient low-dose decitabine treatment on primary AML cells.

Blood

Klco JM,Spencer DH,Lamprecht TL,Sarkaria SM,Wylie T,Magrini V,Hundal J,Walker J,Varghese N,Erdmann-Gilmore P,Lichti CF,Meyer MR,Townsend RR,Wilson RK,Mardis ER,Ley TJ

Thu Feb 28 00:00:00 EST 2013

Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions.

The Journal of clinical investigation

Aziz A,Baxter EJ,Edwards C,Cheong CY,Ito M,Bench A,Kelley R,Silber Y,Beer PA,Chng K,Renfree MB,McEwen K,Gray D,Nangalia J,Mufti GJ,Hellstrom-Lindberg E,Kiladjian JJ,McMullin MF,Campbell PJ,Ferguson-Smith AC,Green AR

Wed May 01 00:00:00 EDT 2013

Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.

The Journal of clinical investigation

Richardson CL,Delehanty LL,Bullock GC,Rival CM,Tung KS,Kimpel DL,Gardenghi S,Rivella S,Goldfarb AN

Thu Aug 01 00:00:00 EDT 2013

Notch pathway activation targets AML-initiating cell homeostasis and differentiation.

The Journal of experimental medicine

Lobry C,Ntziachristos P,Ndiaye-Lobry D,Oh P,Cimmino L,Zhu N,Araldi E,Hu W,Freund J,Abdel-Wahab O,Ibrahim S,Skokos D,Armstrong SA,Levine RL,Park CY,Aifantis I

Mon Feb 11 00:00:00 EST 2013

Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1.

Molecular therapy. Nucleic acids

Centlivre M,Legrand N,Klamer S,Liu YP,Jasmijn von Eije K,Bohne M,Rijnstra ES,Weijer K,Blom B,Voermans C,Spits H,Berkhout B

Tue Sep 03 00:00:00 EDT 2013

TNF-α has tropic rather than apoptotic activity in human hematopoietic progenitors: involvement of TNF receptor-1 and caspase-8.

Stem cells (Dayton, Ohio)

Mizrahi K,Stein J,Yaniv I,Kaplan O,Askenasy N

Tue Jan 01 00:00:00 EST 2013

β-Defensins activate human mast cells via Mas-related gene X2.

Journal of immunology (Baltimore, Md. : 1950)

Subramanian H,Gupta K,Lee D,Bayir AK,Ahn H,Ali H

Mon Jul 01 00:00:00 EDT 2013

Calcineurin-Rcan1 interaction contributes to stem cell factor-mediated mast cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Wu Z,Li Y,MacNeil AJ,Junkins RD,Berman JN,Lin TJ

Sun Dec 15 00:00:00 EST 2013

Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃.

Journal of immunology (Baltimore, Md. : 1950)

Sato T,Kitawaki T,Fujita H,Iwata M,Iyoda T,Inaba K,Ohteki T,Hasegawa S,Kawada K,Sakai Y,Ikeuchi H,Nakase H,Niwa A,Takaori-Kondo A,Kadowaki N

Sun Sep 15 00:00:00 EDT 2013

Cigarette smoke suppresses the surface expression of c-kit and FcεRI on mast cells.

Mediators of inflammation

Givi ME,Blokhuis BR,Da Silva CA,Adcock I,Garssen J,Folkerts G,Redegeld FA,Mortaz E

Mon Aug 19 00:00:00 EDT 2013

Expression of stem cell factor in gastrointestinal stromal tumors: Implications for proliferation and imatinib resistance.

Oncology letters

Hou XW,Bai CG,Liu XH,Qiu C,Huang L,Xu JJ,Ma DL

Fri Feb 01 00:00:00 EST 2013

Infusion of megakaryocytic progenitor products generated from cord blood hematopoietic stem/progenitor cells: results of the phase 1 study.

PloS one

Xi J,Zhu H,Liu D,Nan X,Zheng W,Liu K,Shi W,Chen L,Lv Y,Yan F,Li Y,Xie X,Wang Y,Yue W,Xu X,Wei X,Zhu J,Huang X,Pei X

Fri Jul 19 00:00:00 EDT 2013

Infusion of megakaryocytic progenitor products generated from cord blood hematopoietic stem/progenitor cells: results of the phase 1 study.

PloS one

Xi J,Zhu H,Liu D,Nan X,Zheng W,Liu K,Shi W,Chen L,Lv Y,Yan F,Li Y,Xie X,Wang Y,Yue W,Xu X,Wei X,Zhu J,Huang X,Pei X

Fri Jul 19 00:00:00 EDT 2013

Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.

PloS one

Pick M,Azzola L,Osborne E,Stanley EG,Elefanty AG

Thu Aug 08 00:00:00 EDT 2013

Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.

PloS one

Pick M,Azzola L,Osborne E,Stanley EG,Elefanty AG

Thu Aug 08 00:00:00 EDT 2013

Hematopoietic stem and progenitor cells acquire distinct DNA-hypermethylation during in vitro culture.

Scientific reports

Weidner CI,Walenda T,Lin Q,Wölfler MM,Denecke B,Costa IG,Zenke M,Wagner W

Thu Nov 28 00:00:00 EST 2013

Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.

PloS one

Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK

Wed Jul 03 00:00:00 EDT 2013

Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.

PloS one

Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK

Wed Jul 03 00:00:00 EDT 2013

PI3K/mTOR pathway inhibitors sensitize chronic myeloid leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem cell factor.

Cell death & disease

Airiau K,Mahon FX,Josselin M,Jeanneteau M,Belloc F

Thu Oct 03 00:00:00 EDT 2013

A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells.

PloS one

Gao XN,Lin J,Ning QY,Gao L,Yao YS,Zhou JH,Li YH,Wang LL,Yu L

Fri Jul 19 00:00:00 EDT 2013

A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells.

PloS one

Gao XN,Lin J,Ning QY,Gao L,Yao YS,Zhou JH,Li YH,Wang LL,Yu L

Fri Jul 19 00:00:00 EDT 2013

Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.

Nature methods

Certo MT,Gwiazda KS,Kuhar R,Sather B,Curinga G,Mandt T,Brault M,Lambert AR,Baxter SK,Jacoby K,Ryu BY,Kiem HP,Gouble A,Paques F,Rawlings DJ,Scharenberg AM

Mon Oct 01 00:00:00 EDT 2012

FANCL ubiquitinates β-catenin and enhances its nuclear function.

Blood

Dao KH,Rotelli MD,Petersen CL,Kaech S,Nelson WD,Yates JE,Hanlon Newell AE,Olson SB,Druker BJ,Bagby GC

Thu Jul 12 00:00:00 EDT 2012

Down-regulated expression of hsa-miR-181c in Fanconi anemia patients: implications in TNFα regulation and proliferation of hematopoietic progenitor cells.

Blood

Río P,Agirre X,Garate L,Baños R,Álvarez L,San José-Enériz E,Badell I,Casado JA,Garín M,Prósper F,Bueren JA

Thu Mar 29 00:00:00 EDT 2012

RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion.

Blood

Baudet A,Karlsson C,Safaee Talkhoncheh M,Galeev R,Magnusson M,Larsson J

Thu Jun 28 00:00:00 EDT 2012

APELIN promotes hematopoiesis from human embryonic stem cells.

Blood

Yu QC,Hirst CE,Costa M,Ng ES,Schiesser JV,Gertow K,Stanley EG,Elefanty AG

Thu Jun 28 00:00:00 EDT 2012

Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.

The Journal of clinical investigation

Cesana D,Sgualdino J,Rudilosso L,Merella S,Naldini L,Montini E

Tue May 01 00:00:00 EDT 2012

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.

The Journal of experimental medicine

Thiollier C,Lopez CK,Gerby B,Ignacimouttou C,Poglio S,Duffourd Y,Guégan J,Rivera-Munoz P,Bluteau O,Mabialah V,Diop M,Wen Q,Petit A,Bauchet AL,Reinhardt D,Bornhauser B,Gautheret D,Lecluse Y,Landman-Parker J,Radford I,Vainchenker W,Dastugue N,de Botton S,Dessen P,Bourquin JP,Crispino JD,Ballerini P,Bernard OA,Pflumio F,Mercher T

Mon Oct 22 00:00:00 EDT 2012

Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.

The Journal of experimental medicine

Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H

Mon Oct 22 00:00:00 EDT 2012

Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression.

Nature protocols

Dowey SN,Huang X,Chou BK,Ye Z,Cheng L

300-07 was used in Cell Culture to describe a detailed, validated protocol for effective generation of integration-free human induced pluripotent stem cells from blood mononuclear cells by plasmid vectors.

Thu Nov 01 00:00:00 EDT 2012

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.

Proceedings of the National Academy of Sciences of the United States of America

Roy A,Cowan G,Mead AJ,Filippi S,Bohn G,Chaidos A,Tunstall O,Chan JK,Choolani M,Bennett P,Kumar S,Atkinson D,Wyatt-Ashmead J,Hu M,Stumpf MP,Goudevenou K,O'Connor D,Chou ST,Weiss MJ,Karadimitris A,Jacobsen SE,Vyas P,Roberts I

Tue Oct 23 00:00:00 EDT 2012

GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells.

Oncogene

Joha S,Nugues AL,Hétuin D,Berthon C,Dezitter X,Dauphin V,Mahon FX,Roche-Lestienne C,Preudhomme C,Quesnel B,Idziorek T

Thu Mar 15 00:00:00 EDT 2012

Intercellular cytosolic transfer correlates with mesenchymal stromal cell rescue of umbilical cord blood cell viability during ex vivo expansion.

Cytotherapy

Chu PP,Bari S,Fan X,Gay FP,Ang JM,Chiu GN,Lim SK,Hwang WY

Mon Oct 01 00:00:00 EDT 2012

Characterization and function of histamine receptors in human bone marrow stromal cells.

Stem cells (Dayton, Ohio)

Nemeth K,Wilson T,Rada B,Parmelee A,Mayer B,Buzas E,Falus A,Key S,Masszi T,Karpati S,Mezey E

Wed Feb 01 00:00:00 EST 2012

Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 culture system promote T-cell reconstitution in NOD/SCID/γc(-/-) mice.

Stem cells (Dayton, Ohio)

Reimann C,Six E,Dal-Cortivo L,Schiavo A,Appourchaux K,Lagresle-Peyrou C,de Chappedelaine C,Ternaux B,Coulombel L,Beldjord K,Cavazzana-Calvo M,Andre-Schmutz I

Wed Aug 01 00:00:00 EDT 2012

Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Bilwani FA,Knight KL

Thu Nov 01 00:00:00 EDT 2012

Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Bilwani FA,Knight KL

Thu Nov 01 00:00:00 EDT 2012

Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Bilwani FA,Knight KL

Thu Nov 01 00:00:00 EDT 2012

The aryl hydrocarbon receptor modulates acute and late mast cell responses.

Journal of immunology (Baltimore, Md. : 1950)

Sibilano R,Frossi B,Calvaruso M,Danelli L,Betto E,Dall'Agnese A,Tripodo C,Colombo MP,Pucillo CE,Gri G

Sun Jul 01 00:00:00 EDT 2012

Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens.

Allergy, asthma & immunology research

Kashiwakura J,Okayama Y,Furue M,Kabashima K,Shimada S,Ra C,Siraganian RP,Kawakami Y,Kawakami T

Thu Nov 01 00:00:00 EDT 2012

Generation of virus-free induced pluripotent stem cell clones on a synthetic matrix via a single cell subcloning in the naïve state.

PloS one

Nishishita N,Shikamura M,Takenaka C,Takada N,Fusaki N,Kawamata S

Thu Dec 13 00:00:00 EST 2012

Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities.

PloS one

Aggarwal R,Lu J,Kanji S,Joseph M,Das M,Noble GJ,McMichael BK,Agarwal S,Hart RT,Sun Z,Lee BS,Rosol TJ,Jackson R,Mao HQ,Pompili VJ,Das H

Wed Dec 12 00:00:00 EST 2012

Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics.

PloS one

Danova-Alt R,Heider A,Egger D,Cross M,Alt R

Tue Aug 07 00:00:00 EDT 2012

Residual expression of the reprogramming factors prevents differentiation of iPSC generated from human fibroblasts and cord blood CD34+ progenitors.

PloS one

Ramos-Mejía V,Montes R,Bueno C,Ayllón V,Real PJ,Rodríguez R,Menendez P

Mon Aug 27 00:00:00 EDT 2012

Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model.

PloS one

Banerjee ER,Laflamme MA,Papayannopoulou T,Kahn M,Murry CE,Henderson WR

Fri Aug 03 00:00:00 EDT 2012

Inhibition of Mammalian target of rapamycin in human acute myeloid leukemia cells has diverse effects that depend on the environmental in vitro stress.

Bone marrow research

Ryningen A,Reikvam H,Nepstad I,Paulsen Rye K,Bruserud O

Mon Oct 22 00:00:00 EDT 2012

Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity.

The Journal of biological chemistry

Yang T,Jian W,Luo Y,Fu X,Noguchi C,Bungert J,Huang S,Qiu Y

Fri Nov 23 00:00:00 EST 2012

Direct chromatin PCR (DC-PCR): hypotonic conditions allow differentiation of chromatin states during thermal cycling.

PloS one

Vatolin S,Khan SN,Reu FJ

Tue Mar 12 00:00:00 EDT 2013

Pharmacological inhibition of caspase and calpain proteases: a novel strategy to enhance the homing responses of cord blood HSPCs during expansion.

PloS one

Sangeetha VM,Kadekar D,Kale VP,Limaye LS

Mon May 14 00:00:00 EDT 2012

Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells.

The Journal of biological chemistry

Gao H,Wu X,Sun Y,Zhou S,Silberstein LE,Zhu Z

Fri Aug 24 00:00:00 EDT 2012

Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation.

PloS one

Li XH,Ha CT,Fu D,Xiao M

Thu May 09 00:00:00 EDT 2013

Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells.

Blood cancer journal

Dassé E,Volpe G,Walton DS,Wilson N,Del Pozzo W,O'Neill LP,Slany RK,Frampton J,Dumon S

Fri Jun 01 00:00:00 EDT 2012

Anti-apoptotic BFL-1 is the major effector in activation-induced human mast cell survival.

PloS one

Ekoff M,Lyberg K,Krajewska M,Arvidsson M,Rak S,Reed JC,Harvima I,Nilsson G

Thu Dec 13 00:00:00 EST 2012

RNA sensors enable human mast cell anti-viral chemokine production and IFN-mediated protection in response to antibody-enhanced dengue virus infection.

PloS one

Brown MG,McAlpine SM,Huang YY,Haidl ID,Al-Afif A,Marshall JS,Anderson R

Mon Nov 05 00:00:00 EST 2012

Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications.

PloS one

Yamagata Y,Parietti V,Stockholm D,Corre G,Poinsignon C,Touleimat N,Delafoy D,Besse C,Tost J,Galy A,Paldi A

Wed Jul 24 00:00:00 EDT 2013

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.

Cell

Bock C,Kiskinis E,Verstappen G,Gu H,Boulting G,Smith ZD,Ziller M,Croft GF,Amoroso MW,Oakley DH,Gnirke A,Eggan K,Meissner A

Fri Feb 04 00:00:00 EST 2011

NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes.

Nature methods

Elliott DA,Braam SR,Koutsis K,Ng ES,Jenny R,Lagerqvist EL,Biben C,Hatzistavrou T,Hirst CE,Yu QC,Skelton RJ,Ward-van Oostwaard D,Lim SM,Khammy O,Li X,Hawes SM,Davis RP,Goulburn AL,Passier R,Prall OW,Haynes JM,Pouton CW,Kaye DM,Mummery CL,Elefanty AG,Stanley EG

Sun Oct 23 00:00:00 EDT 2011

Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice.

Cell research

Lu SJ,Li F,Yin H,Feng Q,Kimbrel EA,Hahm E,Thon JN,Wang W,Italiano JE,Cho J,Lanza R

Tue Mar 01 00:00:00 EST 2011

Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia.

Cancer cell

Goardon N,Marchi E,Atzberger A,Quek L,Schuh A,Soneji S,Woll P,Mead A,Alford KA,Rout R,Chaudhury S,Gilkes A,Knapper S,Beldjord K,Begum S,Rose S,Geddes N,Griffiths M,Standen G,Sternberg A,Cavenagh J,Hunter H,Bowen D,Killick S,Robinson L,Price A,Macintyre E,Virgo P,Burnett A,Craddock C,Enver T,Jacobsen SE,Porcher C,Vyas P

Tue Jan 18 00:00:00 EST 2011

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.

Cancer cell

Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R

Tue Sep 13 00:00:00 EDT 2011

JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation.

Cancer cell

Liu F,Zhao X,Perna F,Wang L,Koppikar P,Abdel-Wahab O,Harr MW,Levine RL,Xu H,Tefferi A,Deblasio A,Hatlen M,Menendez S,Nimer SD

Tue Feb 15 00:00:00 EST 2011

Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments.

Blood

Gibbs KD,Gilbert PM,Sachs K,Zhao F,Blau HM,Weissman IL,Nolan GP,Majeti R

Thu Apr 21 00:00:00 EDT 2011

Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia.

Blood

Montes R,Ayllón V,Gutierrez-Aranda I,Prat I,Hernández-Lamas MC,Ponce L,Bresolin S,Te Kronnie G,Greaves M,Bueno C,Menendez P

Thu May 05 00:00:00 EDT 2011

BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription.

Blood

Sheng Z,Ma L,Sun JE,Zhu LJ,Green MR

Thu Sep 08 00:00:00 EDT 2011

Proof of principle for transfusion of in vitro-generated red blood cells.

Blood

Giarratana MC,Rouard H,Dumont A,Kiger L,Safeukui I,Le Pennec PY,François S,Trugnan G,Peyrard T,Marie T,Jolly S,Hebert N,Mazurier C,Mario N,Harmand L,Lapillonne H,Devaux JY,Douay L

Thu Nov 10 00:00:00 EST 2011

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.

Blood

Sun H,Kapuria V,Peterson LF,Fang D,Bornmann WG,Bartholomeusz G,Talpaz M,Donato NJ

Thu Mar 17 00:00:00 EDT 2011

Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.

Blood

Chen TH,Kambal A,Krysiak K,Walshauser MA,Raju G,Tibbitts JF,Walter MJ

Thu Feb 03 00:00:00 EST 2011

TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms.

Blood

Fleischman AG,Aichberger KJ,Luty SB,Bumm TG,Petersen CL,Doratotaj S,Vasudevan KB,LaTocha DH,Yang F,Press RD,Loriaux MM,Pahl HL,Silver RT,Agarwal A,O'Hare T,Druker BJ,Bagby GC,Deininger MW

Thu Dec 08 00:00:00 EST 2011

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.

Blood

Bouma G,Mendoza-Naranjo A,Blundell MP,de Falco E,Parsley KL,Burns SO,Thrasher AJ

Thu Sep 01 00:00:00 EDT 2011

Dendritic cells with lymphocyte-stimulating activity differentiate from human CD133 positive precursors.

Blood

Bonetti MI,Pieri L,Domenici L,Urbani S,Romano G,Aldinucci A,Ballerini C,Monici M,Saccardi R,Basile V,Bosi A,Romagnoli P

Thu Apr 14 00:00:00 EDT 2011

Sox6 enhances erythroid differentiation in human erythroid progenitors.

Blood

Cantù C,Ierardi R,Alborelli I,Fugazza C,Cassinelli L,Piconese S,Bosè F,Ottolenghi S,Ferrari G,Ronchi A

Thu Mar 31 00:00:00 EDT 2011

Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells.

Blood

Hu K,Yu J,Suknuntha K,Tian S,Montgomery K,Choi KD,Stewart R,Thomson JA,Slukvin II

Thu Apr 07 00:00:00 EDT 2011

Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow.

Blood

Matthes T,Dunand-Sauthier I,Santiago-Raber ML,Krause KH,Donze O,Passweg J,McKee T,Huard B

Thu Aug 18 00:00:00 EDT 2011

HTLV-1 propels thymic human T cell development in "human immune system" Rag2⁻/⁻ gamma c⁻/⁻ mice.

PLoS pathogens

Villaudy J,Wencker M,Gadot N,Gillet NA,Scoazec JY,Gazzolo L,Manz MG,Bangham CR,Dodon MD

Thu Sep 01 00:00:00 EDT 2011

Tight control of STAT5 activity determines human CD34-derived interstitial dendritic cell and langerhans cell development.

Journal of immunology (Baltimore, Md. : 1950)

van de Laar L,van den Bosch A,Wierenga AT,Janssen HL,Coffer PJ,Woltman AM

Wed Jun 15 00:00:00 EDT 2011

Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis.

Journal of immunology (Baltimore, Md. : 1950)

Rådinger M,Smrž D,Metcalfe DD,Gilfillan AM

Thu Dec 01 00:00:00 EST 2011

Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors.

PloS one

Mack AA,Kroboth S,Rajesh D,Wang WB

Mon Apr 02 00:00:00 EDT 2012

Hypoxia selects bortezomib-resistant stem cells of chronic myeloid leukemia.

PloS one

Tanturli M,Giuntoli S,Barbetti V,Rovida E,Dello Sbarba P

Fri Feb 11 00:00:00 EST 2011

Generation of bivalent chromatin domains during cell fate decisions.

Epigenetics & chromatin

De Gobbi M,Garrick D,Lynch M,Vernimmen D,Hughes JR,Goardon N,Luc S,Lower KM,Sloane-Stanley JA,Pina C,Soneji S,Renella R,Enver T,Taylor S,Jacobsen SE,Vyas P,Gibbons RJ,Higgs DR

Mon Jun 06 00:00:00 EDT 2011

Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia.

Blood cancer journal

Skavland J,Jørgensen KM,Hadziavdic K,Hovland R,Jonassen I,Bruserud O,Gjertsen BT

Tue Feb 01 00:00:00 EST 2011

Aconitase regulation of erythropoiesis correlates with a novel licensing function in erythropoietin-induced ERK signaling.

PloS one

Talbot AL,Bullock GC,Delehanty LL,Sattler M,Zhao ZJ,Goldfarb AN

Fri Feb 24 00:00:00 EST 2012

Immunoglobulin E oligomers identified in blood components activate mast cells: relevance to anaphylactic transfusion reaction.

Transfusion

Abe T,Matsumoto C,Shimada E,Mazda T,Takanashi M,Kawaguchi K,Hamasaki T,Mita H,Akiyama K,Okazaki H,Satake M,Tadokoro K

300-07 was used in Cell Culture to suggest that these IgEs were dimeric and trimeric and that they directly activated the transfusion recipient's mast cells by triggering the crosslinking of Fcε receptor I, thereby inducing an anaphylactic transfusion reaction.

Tue Nov 01 00:00:00 EDT 2011

Comparative study of hematopoietic differentiation between human embryonic stem cell lines.

PloS one

Melichar H,Li O,Ross J,Haber H,Cado D,Nolla H,Robey EA,Winoto A

Fri Oct 21 00:00:00 EDT 2011

Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.

The Journal of biological chemistry

Sarma NJ,Yaseen NR

Fri Nov 11 00:00:00 EST 2011

Phosphoproteomic analysis of apoptotic hematopoietic stem cells from hemoglobin E/β-thalassemia.

Journal of translational medicine

Ponnikorn S,Panichakul T,Sresanga K,Wongborisuth C,Roytrakul S,Hongeng S,Tungpradabkul S

Sat Jun 25 00:00:00 EDT 2011

Efficient feeder-free episomal reprogramming with small molecules.

PloS one

Yu J,Chau KF,Vodyanik MA,Jiang J,Jiang Y

Tue Mar 01 00:00:00 EST 2011

Eos negatively regulates human γ-globin gene transcription during erythroid differentiation.

PloS one

Yu HC,Zhao HL,Wu ZK,Zhang JW

Tue Dec 06 00:00:00 EST 2011

Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming.

The Journal of biological chemistry

Nishimura K,Sano M,Ohtaka M,Furuta B,Umemura Y,Nakajima Y,Ikehara Y,Kobayashi T,Segawa H,Takayasu S,Sato H,Motomura K,Uchida E,Kanayasu-Toyoda T,Asashima M,Nakauchi H,Yamaguchi T,Nakanishi M

Fri Feb 11 00:00:00 EST 2011

Congenital dyserythropoietic anemia type II: molecular analysis and expression of the SEC23B gene.

Orphanet journal of rare diseases

Punzo F,Bertoli-Avella AM,Scianguetta S,Della Ragione F,Casale M,Ronzoni L,Cappellini MD,Forni G,Oostra BA,Perrotta S

Fri Dec 30 00:00:00 EST 2011

Human fetal liver: an in vitro model of erythropoiesis.

Stem cells international

Pourcher G,Mazurier C,King YY,Giarratana MC,Kobari L,Boehm D,Douay L,Lapillonne H

Thu Nov 10 00:00:00 EST 2011

The Journal of biological chemistry

Subramanian H,Gupta K,Guo Q,Price R,Ali H

Fri Dec 30 00:00:00 EST 2011

Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells.

PloS one

Vibhuti A,Gupta K,Subramanian H,Guo Q,Ali H

Thu May 12 00:00:00 EDT 2011

Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases.

PloS one

Guo Q,Subramanian H,Gupta K,Ali H

Tue Dec 06 00:00:00 EST 2011

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia.

Nature

Cavazzana-Calvo M,Payen E,Negre O,Wang G,Hehir K,Fusil F,Down J,Denaro M,Brady T,Westerman K,Cavallesco R,Gillet-Legrand B,Caccavelli L,Sgarra R,Maouche-Chrétien L,Bernaudin F,Girot R,Dorazio R,Mulder GJ,Polack A,Bank A,Soulier J,Larghero J,Kabbara N,Dalle B,Gourmel B,Socie G,Chrétien S,Cartier N,Aubourg P,Fischer A,Cornetta K,Galacteros F,Beuzard Y,Gluckman E,Bushman F,Hacein-Bey-Abina S,Leboulch P

Thu Sep 16 00:00:00 EDT 2010

β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.

Cancer cell

Yeung J,Esposito MT,Gandillet A,Zeisig BB,Griessinger E,Bonnet D,So CW

Tue Dec 14 00:00:00 EST 2010

The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome.

Blood

Prebet T,Lhoumeau AC,Arnoulet C,Aulas A,Marchetto S,Audebert S,Puppo F,Chabannon C,Sainty D,Santoni MJ,Sebbagh M,Summerour V,Huon Y,Shin WS,Lee ST,Esterni B,Vey N,Borg JP

Thu Sep 30 00:00:00 EDT 2010

The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome.

Blood

Prebet T,Lhoumeau AC,Arnoulet C,Aulas A,Marchetto S,Audebert S,Puppo F,Chabannon C,Sainty D,Santoni MJ,Sebbagh M,Summerour V,Huon Y,Shin WS,Lee ST,Esterni B,Vey N,Borg JP

Thu Sep 30 00:00:00 EDT 2010

The first trimester human placenta is a site for terminal maturation of primitive erythroid cells.

Blood

Van Handel B,Prashad SL,Hassanzadeh-Kiabi N,Huang A,Magnusson M,Atanassova B,Chen A,Hamalainen EI,Mikkola HK

Thu Oct 28 00:00:00 EDT 2010

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.

Blood

Agerstam H,Järås M,Andersson A,Johnels P,Hansen N,Lassen C,Rissler M,Gisselsson D,Olofsson T,Richter J,Fan X,Ehinger M,Fioretos T

Thu Sep 23 00:00:00 EDT 2010

Iron control of erythroid development by a novel aconitase-associated regulatory pathway.

Blood

Bullock GC,Delehanty LL,Talbot AL,Gonias SL,Tong WH,Rouault TA,Dewar B,Macdonald JM,Chruma JJ,Goldfarb AN

Thu Jul 08 00:00:00 EDT 2010

Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors.

Blood

Yu C,Liu Y,Miao Z,Yin M,Lu W,Lv Y,Ding M,Deng H

Thu Dec 02 00:00:00 EST 2010

Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera.

Blood

Perna F,Gurvich N,Hoya-Arias R,Abdel-Wahab O,Levine RL,Asai T,Voza F,Menendez S,Wang L,Liu F,Zhao X,Nimer SD

Thu Oct 14 00:00:00 EDT 2010

The BH3-mimetic ABT-737 induces mast cell apoptosis in vitro and in vivo: potential for therapeutics.

Journal of immunology (Baltimore, Md. : 1950)

Karlberg M,Ekoff M,Huang DC,Mustonen P,Harvima IT,Nilsson G

Sun Aug 15 00:00:00 EDT 2010

Protein tyrosine nitration of aldolase in mast cells: a plausible pathway in nitric oxide-mediated regulation of mast cell function.

Journal of immunology (Baltimore, Md. : 1950)

Sekar Y,Moon TC,Slupsky CM,Befus AD

Thu Jul 01 00:00:00 EDT 2010

A nonredundant role for canonical NF-κB in human myeloid dendritic cell development and function.

Journal of immunology (Baltimore, Md. : 1950)

van de Laar L,van den Bosch A,van der Kooij SW,Janssen HL,Coffer PJ,van Kooten C,Woltman AM

Wed Dec 15 00:00:00 EST 2010

Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling.

Journal of immunology (Baltimore, Md. : 1950)

van de Laar L,Buitenhuis M,Wensveen FM,Janssen HL,Coffer PJ,Woltman AM

Tue Jun 15 00:00:00 EDT 2010

IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis.

Journal of immunology (Baltimore, Md. : 1950)

Macey MR,Sturgill JL,Morales JK,Falanga YT,Morales J,Norton SK,Yerram N,Shim H,Fernando J,Gifillan AM,Gomez G,Schwartz L,Oskeritzian C,Spiegel S,Conrad D,Ryan JJ

Sat May 01 00:00:00 EDT 2010

Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Rådinger M,Kuehn HS,Kim MS,Metcalfe DD,Gilfillan AM

Fri Jan 15 00:00:00 EST 2010

Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.

Journal of immunology (Baltimore, Md. : 1950)

Lee SH,Yun S,Piao ZH,Jeong M,Kim DO,Jung H,Lee J,Kim MJ,Kim MS,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I

Thu Jul 15 00:00:00 EDT 2010

CXCR7 protein is not expressed on human or mouse leukocytes.

Journal of immunology (Baltimore, Md. : 1950)

Berahovich RD,Zabel BA,Penfold ME,Lewén S,Wang Y,Miao Z,Gan L,Pereda J,Dias J,Slukvin II,McGrath KE,Jaen JC,Schall TJ

Mon Nov 01 00:00:00 EDT 2010

CXCR7 protein is not expressed on human or mouse leukocytes.

Journal of immunology (Baltimore, Md. : 1950)

Berahovich RD,Zabel BA,Penfold ME,Lewén S,Wang Y,Miao Z,Gan L,Pereda J,Dias J,Slukvin II,McGrath KE,Jaen JC,Schall TJ

Mon Nov 01 00:00:00 EDT 2010

CD72 negatively regulates KIT-mediated responses in human mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Kataoka TR,Kumanogoh A,Bandara G,Metcalfe DD,Gilfillan AM

Mon Mar 01 00:00:00 EST 2010

T cell-induced mast cell activation: a role for microparticles released from activated T cells.

Journal of immunology (Baltimore, Md. : 1950)

Shefler I,Salamon P,Reshef T,Mor A,Mekori YA

Fri Oct 01 00:00:00 EDT 2010

Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Niyonsaba F,Ushio H,Hara M,Yokoi H,Tominaga M,Takamori K,Kajiwara N,Saito H,Nagaoka I,Ogawa H,Okumura K

Thu Apr 01 00:00:00 EDT 2010

miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation.

Journal of immunology (Baltimore, Md. : 1950)

Jurkin J,Schichl YM,Koeffel R,Bauer T,Richter S,Konradi S,Gesslbauer B,Strobl H

Sat May 01 00:00:00 EDT 2010

Development of lentiviral vectors with optimized transcriptional activity for the gene therapy of patients with Fanconi anemia.

Human gene therapy

González-Murillo A,Lozano ML,Alvarez L,Jacome A,Almarza E,Navarro S,Segovia JC,Hanenberg H,Guenechea G,Bueren JA,Río P

Sat May 01 00:00:00 EDT 2010

Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.

BMC immunology

Ersvaer E,Liseth K,Skavland J,Gjertsen BT,Bruserud Ø

Fri Jul 09 00:00:00 EDT 2010

Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells.

The Journal of biological chemistry

Chang YI,Hua WK,Yao CL,Hwang SM,Hung YC,Kuan CJ,Leou JS,Lin WJ

Fri Jul 02 00:00:00 EDT 2010

Expansion of cord blood CD34 cells in presence of zVADfmk and zLLYfmk improved their in vitro functionality and in vivo engraftment in NOD/SCID mouse.

PloS one

V M S,Kale VP,Limaye LS

Tue Aug 17 00:00:00 EDT 2010

Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells.

PloS one

Valeri A,Alonso-Ferrero ME,Río P,Pujol MR,Casado JA,Pérez L,Jacome A,Agirre X,Calasanz MJ,Hanenberg H,Surrallés J,Prosper F,Albella B,Bueren JA

Tue Dec 28 00:00:00 EST 2010

Erythroid progenitor cells expanded from peripheral blood without mobilization or preselection: molecular characteristics and functional competence.

PloS one

Filippone C,Franssila R,Kumar A,Saikko L,Kovanen PE,Söderlund-Venermo M,Hedman K

Tue Mar 02 00:00:00 EST 2010

Generation of induced pluripotent stem cells from human cord blood cells with only two factors: Oct4 and Sox2.

Nature protocols

Giorgetti A,Montserrat N,Rodriguez-Piza I,Azqueta C,Veiga A,Izpisúa Belmonte JC

Thu Apr 01 00:00:00 EDT 2010

In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AML.

PloS one

Abdul-Nabi AM,Yassin ER,Varghese N,Deshmukh H,Yaseen NR

Fri Aug 27 00:00:00 EDT 2010

ErythRED, a hESC line enabling identification of erythroid cells.

Nature methods

Hatzistavrou T,Micallef SJ,Ng ES,Vadolas J,Stanley EG,Elefanty AG

Tue Sep 01 00:00:00 EDT 2009

Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity.

Blood

Woll PS,Grzywacz B,Tian X,Marcus RK,Knorr DA,Verneris MR,Kaufman DS

Thu Jun 11 00:00:00 EDT 2009

Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome.

Blood

Will B,Kawahara M,Luciano JP,Bruns I,Parekh S,Erickson-Miller CL,Aivado MA,Verma A,Steidl U

Thu Oct 29 00:00:00 EDT 2009

AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms.

Blood

Ding Y,Harada Y,Imagawa J,Kimura A,Harada H

Thu Dec 10 00:00:00 EST 2009

Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells.

Blood

McKinney-Freeman SL,Naveiras O,Yates F,Loewer S,Philitas M,Curran M,Park PJ,Daley GQ

Thu Jul 09 00:00:00 EDT 2009

The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells.

Blood

Oehler VG,Guthrie KA,Cummings CL,Sabo K,Wood BL,Gooley T,Yang T,Epping MT,Shou Y,Pogosova-Agadjanyan E,Ladne P,Stirewalt DL,Abkowitz JL,Radich JP

Thu Oct 08 00:00:00 EDT 2009

Role for MKL1 in megakaryocytic maturation.

Blood

Cheng EC,Luo Q,Bruscia EM,Renda MJ,Troy JA,Massaro SA,Tuck D,Schulz V,Mane SM,Berliner N,Sun Y,Morris SW,Qiu C,Krause DS

Thu Mar 19 00:00:00 EDT 2009

Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.

Blood

Kandilci A,Grosveld GC

Thu Aug 20 00:00:00 EDT 2009

Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells.

Blood

Awong G,Herer E,Surh CD,Dick JE,La Motte-Mohs RN,Zúñiga-Pflücker JC

Thu Jul 30 00:00:00 EDT 2009

Generation of induced pluripotent stem cells from human blood.

Blood

Loh YH,Agarwal S,Park IH,Urbach A,Huo H,Heffner GC,Kim K,Miller JD,Ng K,Daley GQ

Thu May 28 00:00:00 EDT 2009

Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis.

Blood

Pendino F,Nguyen E,Jonassen I,Dysvik B,Azouz A,Lanotte M,Ségal-Bendirdjian E,Lillehaug JR

Thu Apr 02 00:00:00 EDT 2009

Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation.

Blood

Göbel F,Taschner S,Jurkin J,Konradi S,Vaculik C,Richter S,Kneidinger D,Mühlbacher C,Bieglmayer C,Elbe-Bürger A,Strobl H

Thu Oct 29 00:00:00 EDT 2009

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

Blood

Eberhard Y,McDermott SP,Wang X,Gronda M,Venugopal A,Wood TE,Hurren R,Datti A,Batey RA,Wrana J,Antholine WE,Dick JE,Schimmer AD

Thu Oct 01 00:00:00 EDT 2009

The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.

The Journal of clinical investigation

Ford AM,Palmi C,Bueno C,Hong D,Cardus P,Knight D,Cazzaniga G,Enver T,Greaves M

Wed Apr 01 00:00:00 EDT 2009

MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization.

The Journal of clinical investigation

Vagima Y,Avigdor A,Goichberg P,Shivtiel S,Tesio M,Kalinkovich A,Golan K,Dar A,Kollet O,Petit I,Perl O,Rosenthal E,Resnick I,Hardan I,Gellman YN,Naor D,Nagler A,Lapidot T

Sun Mar 01 00:00:00 EST 2009

Hyperexpression of NOD2 in intestinal mast cells of Crohn's disease patients: preferential expression of inflammatory cell-recruiting molecules via NOD2 in mast cells.

Clinical immunology (Orlando, Fla.)

Okumura S,Yuki K,Kobayashi R,Okamura S,Ohmori K,Saito H,Ra C,Okayama Y

Sun Feb 01 00:00:00 EST 2009

Tumor immunotherapy using gene-modified human mesenchymal stem cells loaded into synthetic extracellular matrix scaffolds.

Stem cells (Dayton, Ohio)

Compte M,Cuesta AM,Sánchez-Martín D,Alonso-Camino V,Vicario JL,Sanz L,Alvarez-Vallina L

Sun Mar 01 00:00:00 EST 2009

Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells.

Stem cells (Dayton, Ohio)

Tian X,Hexum MK,Penchev VR,Taylor RJ,Shultz LD,Kaufman DS

Sun Nov 01 00:00:00 EDT 2009

A feeder-free and efficient production of functional neutrophils from human embryonic stem cells.

Stem cells (Dayton, Ohio)

Saeki K,Saeki K,Nakahara M,Matsuyama S,Nakamura N,Yogiashi Y,Yoneda A,Koyanagi M,Kondo Y,Yuo A

Thu Jan 01 00:00:00 EST 2009

Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Platzer B,Richter S,Kneidinger D,Waltenberger D,Woisetschläger M,Strobl H

Wed Jul 01 00:00:00 EDT 2009

IgE-FcepsilonRI interactions determine HIV coreceptor usage and susceptibility to infection during ontogeny of mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Sundstrom JB,Hair GA,Ansari AA,Secor WE,Gilfillan AM,Metcalfe DD,Kirshenbaum AS

Fri May 15 00:00:00 EDT 2009

IL-7 enhances thymic human T cell development in "human immune system" Rag2-/-IL-2Rgammac-/- mice without affecting peripheral T cell homeostasis.

Journal of immunology (Baltimore, Md. : 1950)

van Lent AU,Dontje W,Nagasawa M,Siamari R,Bakker AQ,Pouw SM,Maijoor KA,Weijer K,Cornelissen JJ,Blom B,Di Santo JP,Spits H,Legrand N

Tue Dec 15 00:00:00 EST 2009

Dexamethasone and FK506 inhibit expression of distinct subsets of chemokines in human mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Kato A,Chustz RT,Ogasawara T,Kulka M,Saito H,Schleimer RP,Matsumoto K

Mon Jun 01 00:00:00 EDT 2009

The cathelicidin LL-37 activates human mast cells and is degraded by mast cell tryptase: counter-regulation by CXCL4.

Journal of immunology (Baltimore, Md. : 1950)

Schiemann F,Brandt E,Gross R,Lindner B,Mittelstädt J,Sommerhoff CP,Schulmistrat J,Petersen F

Sat Aug 15 00:00:00 EDT 2009

The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells.

Journal of immunology (Baltimore, Md. : 1950)

Boehmler AM,Drost A,Jaggy L,Seitz G,Wiesner T,Denzlinger C,Kanz L,Möhle R

Mon Jun 01 00:00:00 EDT 2009

RasGRP1 is required for human NK cell function.

Journal of immunology (Baltimore, Md. : 1950)

Lee SH,Yun S,Lee J,Kim MJ,Piao ZH,Jeong M,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I

Tue Dec 15 00:00:00 EST 2009

Kinetics and effect of integrin expression on human CD34(+) cells during murine leukemia virus-derived retroviral transduction with recombinant fibronectin for stem cell gene therapy.

Human gene therapy

Horiuchi Y,Onodera M,Miyagawa Y,Sato B,Onda K,Katagiri YU,Okita H,Okada M,Otsu M,Kume A,Okuyama T,Fujimoto J,Kuratsuji T,Kiyokawa N

Wed Jul 01 00:00:00 EDT 2009

Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model.

PloS one

Das H,George JC,Joseph M,Das M,Abdulhameed N,Blitz A,Khan M,Sakthivel R,Mao HQ,Hoit BD,Kuppusamy P,Pompili VJ

Wed Oct 07 00:00:00 EDT 2009

Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.

PloS one

Robert G,Ben Sahra I,Puissant A,Colosetti P,Belhacene N,Gounon P,Hofman P,Bost F,Cassuto JP,Auberger P

Wed Nov 18 00:00:00 EST 2009

Human mast cell activation with virus-associated stimuli leads to the selective chemotaxis of natural killer cells by a CXCL8-dependent mechanism.

Blood

Burke SM,Issekutz TB,Mohan K,Lee PW,Shmulevitz M,Marshall JS

Sun Jun 15 00:00:00 EDT 2008

Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors.

Blood

Takayama N,Nishikii H,Usui J,Tsukui H,Sawaguchi A,Hiroyama T,Eto K,Nakauchi H

Sun Jun 01 00:00:00 EDT 2008

Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions.

Clinical cancer research : an official journal of the American Association for Cancer Research

Su Z,Frye C,Bae KM,Kelley V,Vieweg J

Wed Oct 01 00:00:00 EDT 2008

Identification of a small subpopulation of candidate leukemia-initiating cells in the side population of patients with acute myeloid leukemia.

Stem cells (Dayton, Ohio)

Moshaver B,van Rhenen A,Kelder A,van der Pol M,Terwijn M,Bachas C,Westra AH,Ossenkoppele GJ,Zweegman S,Schuurhuis GJ

Mon Dec 01 00:00:00 EST 2008

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Kuehn HS,Swindle EJ,Kim MS,Beaven MA,Metcalfe DD,Gilfillan AM

Mon Dec 01 00:00:00 EST 2008

Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A.

Journal of immunology (Baltimore, Md. : 1950)

Prasad P,Yanagihara AA,Small-Howard AL,Turner H,Stokes AJ

Wed Oct 01 00:00:00 EDT 2008

Hematopoietic progenitor cells and interleukin-stimulated endothelium: expansion and differentiation of myeloid precursors.

BMC immunology

Moldenhauer A,Genter G,Lun A,Bal G,Kiesewetter H,Salama A

Wed Oct 01 00:00:00 EDT 2008

Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition.

BMC immunology

Kirshenbaum AS,Swindle E,Kulka M,Wu Y,Metcalfe DD

Thu Aug 07 00:00:00 EDT 2008

Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon.

Oncogene

Rigby RJ,Simmons JG,Greenhalgh CJ,Alexander WS,Lund PK

Thu Jul 19 00:00:00 EDT 2007

Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Sawamukai N,Saito K,Yamaoka K,Nakayamada S,Ra C,Tanaka Y

300-07 was used in Cell Culture to indicate a new way of controlling mast cells and may therefore be the basis for innovative approaches to the treatment of various diseases related to mast cells.

Thu Nov 15 00:00:00 EST 2007

Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G.

Blood

Schiemann F,Grimm TA,Hoch J,Gross R,Lindner B,Petersen F,Bulfone-Paus S,Brandt E

Wed Mar 15 00:00:00 EST 2006

Culture of human mast cells from hemopoietic progenitors.

Methods in molecular biology (Clifton, N.J.)

Saito H

300-07 was used in Cell Culture to introduce the method of forming human mast cell colonies by culturing purified cord blood cells and peripheral blood cells in serum-free methylcellulose supplemented with stem cell factor and interleukin-6 for 6 wk.

Tue Dec 06 00:00:00 EST 2005

Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.

The Journal of experimental medicine

Weller CL,Collington SJ,Brown JK,Miller HR,Al-Kashi A,Clark P,Jose PJ,Hartnell A,Williams TJ

Mon Jun 20 00:00:00 EDT 2005

Are interleukin-16 and thrombopoietin new tools for the in vitro generation of dendritic cells?

Blood

Della Bella S,Nicola S,Timofeeva I,Villa ML,Santoro A,Berardi AC

Wed Dec 15 00:00:00 EST 2004

Enhanced protein profiling arrays with ELISA-based amplification for high-throughput molecular changes of tumor patients' plasma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Huang R,Lin Y,Shi Q,Flowers L,Ramachandran S,Horowitz IR,Parthasarathy S,Huang RP

Thu Jan 15 00:00:00 EST 2004

Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.

Cancer research

Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT

Sat Feb 15 00:00:00 EST 2003

Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcepsilon receptor I cross-linking: an interspecies comparison.

Blood

Nakajima T,Inagaki N,Tanaka H,Tanaka A,Yoshikawa M,Tamari M,Hasegawa K,Matsumoto K,Tachimoto H,Ebisawa M,Tsujimoto G,Matsuda H,Nagai H,Saito H

Sun Dec 01 00:00:00 EST 2002

Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells.

Blood

Burger PE,Coetzee S,McKeehan WL,Kan M,Cook P,Fan Y,Suda T,Hebbel RP,Novitzky N,Muller WA,Wilson EL

Fri Nov 15 00:00:00 EST 2002

Bioinformatics

Protein Aliases: c-Kit ligand; DKFZp686F2250; familial progressive hyperpigmentation 2; H-SCF; Kit ligand; kit-ligand; M-SCF; Mast cell growth factor; MGF; SCF; steel factor; Stem cell factor

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Gene Aliases: DCUA; DFNA69; FPH2; FPHH; Kitl; KITLG; KL-1; MGF; SCF; SF; SHEP7

Human SCF Recombinant Protein, PeproTech®

Human SCF Protein (300-07-10UG) in Functional

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300-07-10UG

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