Product References
Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.
British journal of haematology
Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y
300-07 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.
Sat Jul 01 00:00:00 EDT 2023
Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages.
The Journal of cell biology
Pellegrino E,Aylan B,Bussi C,Fearns A,Bernard EM,Athanasiadi N,Santucci P,Botella L,Gutierrez MG
300-07 was used in In vitro experiments to find peroxisomes increased ROS levels during Mtb WT infection.
Mon Dec 04 00:00:00 EST 2023
Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction.
Communications biology
Breitmeyer R,Vogel S,Heider J,Hartmann SM,Wüst R,Keller AL,Binner A,Fitzgerald JC,Fallgatter AJ,Volkmer H
300-07 was used in Cell Culture to present a co-culture model of neurons and microglia, both of human origin, to show increased susceptibility of neurons to microglia-like cells derived from SCZ patients.
Sat Apr 29 00:00:00 EDT 2023
An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming.
Science advances
Weng M,Hu H,Graus MS,Tan DS,Gao Y,Ren S,Ho DHH,Langer J,Holzner M,Huang Y,Ling GS,Lai CSW,Francois M,Jauch R
300-07 was used in In vitro experiments to report iNSC reprogramming from embryonic and aged mouse fibroblasts as well as from human blood using an engineered Sox17 (eSox17FNV).
Fri Aug 25 00:00:00 EDT 2023
ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages.
Nature microbiology
Aylan B,Bernard EM,Pellegrino E,Botella L,Fearns A,Athanasiadi N,Bussi C,Santucci P,Gutierrez MG
300-07 was used in Cell Culture to conclude that ATG7 and ATG14 are both required for restricting Mtb replication in human macrophages.
Mon May 01 00:00:00 EDT 2023
C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages.
iScience
Tian L,Li H,Zhao P,Liu Y,Lu Y,Zhong R,Jin Y,Tan T,Cheng Y
300-07 was used in Cell Culture to provide a comprehensive overview of the cancer-specific immune signature of monocytes and macrophages and reveals tumor-associated biomarkers as potential therapeutic targets for SCLC.
Fri Oct 20 00:00:00 EDT 2023
Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors.
Methods in molecular biology (Clifton, N.J.)
Chen SW,Wong YH
300-07 was used in Cell Culture to provide a stepwise protocol for the simple, robust, and efficient differentiation of hiPSCs into microglia-like cells (iMGs) by overexpression of SPI1 and CEBPA.
Mon Jun 12 00:00:00 EDT 2023
Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B.
The Journal of clinical investigation
Azad P,Zhou D,Tu HC,Villafuerte FC,Traver D,Rana TM,Haddad GG
300-07 was used in In vitro experiments to conclude that HIKER regulates erythropoiesis in Monge's disease and acts through at least one specific target, CSNK2B, a casein kinase.
Thu Jun 01 00:00:00 EDT 2023
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
Nature neuroscience
Dräger NM,Sattler SM,Huang CT,Teter OM,Leng K,Hashemi SH,Hong J,Aviles G,Clelland CD,Zhan L,Udeochu JC,Kodama L,Singleton AB,Nalls MA,Ichida J,Ward ME,Faghri F,Gan L,Kampmann M
300-07 was used in In vitro experiments to present a screening platform to systematically elucidate functional consequences of genetic perturbations in human induced pluripotent stem cell-derived microglia.
Thu Sep 01 00:00:00 EDT 2022
Disease-associated mutations in topoisomerase IIβ result in defective NK cells.
The Journal of allergy and clinical immunology
Broderick L,Clay GM,Blum RH,Liu Y,McVicar R,Papes F,Booshehri LM,Cowell IG,Austin CA,Putnam CD,Kaufman DS
300-07 was used in Cell Culture to support that Hoffman syndrome-associated mutations in TOP2B impact NK-cell development and function in murine and human models.
Wed Jun 01 00:00:00 EDT 2022
The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis.
Leukemia
Stavast CJ,van Zuijen I,Karkoulia E,Özçelik A,van Hoven-Beijen A,Leon LG,Voerman JSA,Janssen GMC,van Veelen PA,Burocziova M,Brouwer RWW,van IJcken WFJ,Maas A,Bindels EM,van der Velden VHJ,Schliehe C,Katsikis PD,Alberich-Jorda M,Erkeland SJ
300-07 was used in Cell Culture to investigate miRNA-139 in acute myeloid leukemia.
Tue Mar 01 00:00:00 EST 2022
A comparison of DNA repair pathways to achieve a site-specific gene modification of the Bruton's tyrosine kinase gene.
Molecular therapy. Nucleic acids
Gray DH,Santos J,Keir AG,Villegas I,Maddock S,Trope EC,Long JD,Kuo CY
300-07 was used in Cell Culture to compare three methods of targeted insertion — homology-directed repair (HDR), homology-independent targeted integration (HITI), and precise integration into target chromosome (PITCh) — to achieve a permanent gene-therapy-based cure for X-linked agammaglobulinemia.
Tue Mar 08 00:00:00 EST 2022
Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.
Cellular and molecular life sciences : CMLS
Solomon S,Sampathkumar NK,Carre I,Mondal M,Chennell G,Vernon AC,Ruepp MD,Mitchell JC
300-07 was used in Sample Preparation to investigate P522R in Alzheimer’s disease.
Wed Jul 27 00:00:00 EDT 2022
Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.
EMBO reports
Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB
300-07 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.
Thu Feb 03 00:00:00 EST 2022
Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.
EMBO reports
Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB
300-07 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.
Thu Feb 03 00:00:00 EST 2022
Patient-specific, re-engineered cardiomyocyte model confirms the circumstance-dependent arrhythmia risk associated with the African-specific common SCN5A polymorphism p.S1103Y: Implications for the increased sudden deaths observed in black individuals during the COVID-19 pandemic.
Heart rhythm
Hamrick SK,John Kim CS,Tester DJ,Giudicessi JR,Ackerman MJ
300-07 was used in Cell Culture to ascertain the effects of acidosis and hydroxychloroquine (HCQ) on the action potential duration (APD) in a patient-specific induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of p.S1103Y-SCN5A.
Sun May 01 00:00:00 EDT 2022
A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.
RNA (New York, N.Y.)
Hug N,Aitken S,Longman D,Raab M,Armes H,Mann AR,Rio-Machin A,Fitzgibbon J,Rouault-Pierre K,Cáceres JF
300-07 was used in In vitro experiments to investigate NMD factors and the role of DNX34 in the spliceosome.
Thu Sep 01 00:00:00 EDT 2022
Quantitative Proteomics of Polarised Macrophages Derived from Induced Pluripotent Stem Cells.
Biomedicines
Murugesan G,Davidson L,Jannetti L,Crocker PR,Weigle B
300-07 was used in Cell Culture to generate and culture embroyoid bodies (iPSCs). Polarised to either M1 or M2, the macrophages were subjected to quantitative proteomic analysis gaining further insight into their functionalities.
Sun Jan 23 00:00:00 EST 2022
Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis.
mBio
Santucci P,Aylan B,Botella L,Bernard EM,Bussi C,Pellegrino E,Athanasiadi N,Gutierrez MG
300-07 was used in Cell Culture to describe a dual live imaging approach to monitor mycobacterial pH homeostasis, host cell environment, and antibiotic action, and show that intracellular localization of M. tuberculosis affects the efficacy of pyrazinamide.
Tue Apr 26 00:00:00 EDT 2022
Using Cryo-ET to distinguish platelets during pre-acute myeloid leukemia from steady state hematopoiesis.
Communications biology
Wang Y,Huo T,Tseng YJ,Dang L,Yu Z,Yu W,Foulks Z,Murdaugh RL,Ludtke SJ,Nakada D,Wang Z
Thu Jan 20 00:00:00 EST 2022
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.
Cell stem cell
Jin M,Xu R,Wang L,Alam MM,Ma Z,Zhu S,Martini AC,Jadali A,Bernabucci M,Xie P,Kwan KY,Pang ZP,Head E,Liu Y,Hart RP,Jiang P
300-07 was used in Cell Culture to provide in vivo evidence that human microglia respond to pathological tau by exhibiting dystrophic phenotypes.
Thu Jul 07 00:00:00 EDT 2022
Generation, expansion, and drug treatment of hematopoietic progenitor cells derived from human iPSCs.
STAR protocols
Dannenmann B,Skokowa J
300-07 was used in Cell Culture to provide protocol for generation of HPCs from iPSCs followed by HPC expansion on Sl/Sl feeder cells expressing FLT3L.
Fri Jun 17 00:00:00 EDT 2022
Decoding the pathogenesis of Diamond-Blackfan anemia using single-cell RNA-seq.
Cell discovery
Wang B,Wang C,Wan Y,Gao J,Ma Y,Zhang Y,Tong J,Zhang Y,Liu J,Chang L,Xu C,Shen B,Chen Y,Jiang E,Kurita R,Nakamura Y,Lim KC,Engel JD,Zhou J,Cheng T,Zhu X,Zhu P,Shi L
300-07 was used in Cell Culture to demonstrate that interferon-mediated cell cycle control underlies the clinical efficacy of glucocorticoids.
Tue May 10 00:00:00 EDT 2022
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters.
iScience
van Gils N,Verhagen HJMP,Broux M,Martiáñez T,Denkers F,Vermue E,Rutten A,Csikós T,Demeyer S,Çil M,Al M,Cools J,Janssen JJWM,Ossenkoppele GJ,Menezes RX,Smit L
300-07 was used in Cell Culture to reveal plasticity of anthracycline resistance in AML cells and highlight the potential of transcriptional reprogramming by epigenetic-based therapeutics to target chemotherapy-resistant AML cells.
Fri Sep 16 00:00:00 EDT 2022
Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells.
Nature genetics
Qin K,Huang P,Feng R,Keller CA,Peslak SA,Khandros E,Saari MS,Lan X,Mayuranathan T,Doerfler PA,Abdulmalik O,Giardine B,Chou ST,Shi J,Hardison RC,Weiss MJ,Blobel GA
300-07 was used in Cell Culture to identify via a CRISPR-Cas9 genetic screen two members of the NFI transcription factor family-NFIA and NFIX-as HBG1/2 repressors.
Wed Jun 01 00:00:00 EDT 2022
Single-nucleotide-level mapping of DNA regulatory elements that control fetal hemoglobin expression.
Nature genetics
Cheng L,Li Y,Qi Q,Xu P,Feng R,Palmer L,Chen J,Wu R,Yee T,Zhang J,Yao Y,Sharma A,Hardison RC,Weiss MJ,Cheng Y
300-07 was used in Cell Culture to develop a high-throughput framework to map noncoding DNA in sickle cell disease.
Tue Jun 01 00:00:00 EDT 2021
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.
Cancer cell
Cheng Y,Xie W,Pickering BF,Chu KL,Savino AM,Yang X,Luo H,Nguyen DT,Mo S,Barin E,Velleca A,Rohwetter TM,Patel DJ,Jaffrey SR,Kharas MG
300-07 was used in In vitro experiments to investigate How N6-Methyladenosine dictates its diverse molecular and cellular effects in leukemias.
Mon Jul 12 00:00:00 EDT 2021
Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia.
Cancer discovery
Montefiori LE,Bendig S,Gu Z,Chen X,Pölönen P,Ma X,Murison A,Zeng A,Garcia-Prat L,Dickerson K,Iacobucci I,Abdelhamed S,Hiltenbrand R,Mead PE,Mehr CM,Xu B,Cheng Z,Chang TC,Westover T,Ma J,Stengel A,Kimura S,Qu C,Valentine MB,Rashkovan M,Luger S,Litzow MR,Rowe JM,den Boer ML,Wang V,Yin J,Kornblau SM,Hunger SP,Loh ML,Pui CH,Yang W,Crews KR,Roberts KG,Yang JJ,Relling MV,Evans WE,Stock W,Paietta EM,Ferrando AA,Zhang J,Kern W,Haferlach T,Wu G,Dick JE,Klco JM,Haferlach C,Mullighan CG
300-07 was used in In vitro experiments to identify oncogenic deregulation of BCL11B driven by diverse structural alterations, including de novo superenhancer generation, as the driving feature of a subset of lineage-ambiguous leukemias that transcend current diagnostic boundaries.
Mon Nov 01 00:00:00 EDT 2021
M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity.
Signal transduction and targeted therapy
Zhao HY,Zhang YY,Xing T,Tang SQ,Wen Q,Lyu ZS,Lv M,Wang Y,Xu LP,Zhang XH,Kong Y,Huang XJ
Fri Jun 18 00:00:00 EDT 2021
Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms.
Blood
Mosca M,Hermange G,Tisserand A,Noble R,Marzac C,Marty C,Le Sueur C,Campario H,Vertenoeil G,El-Khoury M,Catelain C,Rameau P,Gella C,Lenglet J,Casadevall N,Favier R,Solary E,Cassinat B,Kiladjian JJ,Constantinescu SN,Pasquier F,Hochberg ME,Raslova H,Villeval JL,Girodon F,Vainchenker W,Cournède PH,Plo I
Thu Dec 02 00:00:00 EST 2021
Dynamic CTCF binding directly mediates interactions among cis-regulatory elements essential for hematopoiesis.
Blood
Qi Q,Cheng L,Tang X,He Y,Li Y,Yee T,Shrestha D,Feng R,Xu P,Zhou X,Pruett-Miller S,Hardison RC,Weiss MJ,Cheng Y
Thu Mar 11 00:00:00 EST 2021
Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging.
Cell stem cell
Kruta M,Sunshine MJ,Chua BA,Fu Y,Chawla A,Dillingham CH,Hidalgo San Jose L,De Jong B,Zhou FJ,Signer RAJ
Thu Nov 04 00:00:00 EDT 2021
MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia.
Cell stem cell
Rodríguez A,Zhang K,Färkkilä A,Filiatrault J,Yang C,Velázquez M,Furutani E,Goldman DC,García de Teresa B,Garza-Mayén G,McQueen K,Sambel LA,Molina B,Torres L,González M,Vadillo E,Pelayo R,Fleming WH,Grompe M,Shimamura A,Hautaniemi S,Greenberger J,Frías S,Parmar K,D'Andrea AD
300-07 was used in In vitro experiments to identify determinants of bone marrow failure, we performed single-cell transcriptome profiling of primary hematopoietic stem and progenitor cells from Fanconi anemia patients.
Thu Jan 07 00:00:00 EST 2021
Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms.
Cell stem cell
Van Egeren D,Escabi J,Nguyen M,Liu S,Reilly CR,Patel S,Kamaz B,Kalyva M,DeAngelo DJ,Galinsky I,Wadleigh M,Winer ES,Luskin MR,Stone RM,Garcia JS,Hobbs GS,Camargo FD,Michor F,Mullally A,Cortes-Ciriano I,Hormoz S
Thu Mar 04 00:00:00 EST 2021
Dissecting ELANE neutropenia pathogenicity by human HSC gene editing.
Cell stem cell
Rao S,Yao Y,Soares de Brito J,Yao Q,Shen AH,Watkinson RE,Kennedy AL,Coyne S,Ren C,Zeng J,Serbin AV,Studer S,Ballotti K,Harris CE,Luk K,Stevens CS,Armant M,Pinello L,Wolfe SA,Chiarle R,Shimamura A,Lee B,Newburger PE,Bauer DE
Thu May 06 00:00:00 EDT 2021
Principles of signaling pathway modulation for enhancing human naive pluripotency induction.
Cell stem cell
Bayerl J,Ayyash M,Shani T,Manor YS,Gafni O,Massarwa R,Kalma Y,Aguilera-Castrejon A,Zerbib M,Amir H,Sheban D,Geula S,Mor N,Weinberger L,Naveh Tassa S,Krupalnik V,Oldak B,Livnat N,Tarazi S,Tawil S,Wildschutz E,Ashouokhi S,Lasman L,Rotter V,Hanna S,Ben-Yosef D,Novershtern N,Viukov S,Hanna JH
Thu Sep 02 00:00:00 EDT 2021
A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors.
Cellular & molecular immunology
Moirangthem RD,Ma K,Lizot S,Cordesse A,Olivré J,de Chappedelaine C,Joshi A,Cieslak A,Tchen J,Cagnard N,Asnafi V,Rausell A,Simons L,Zuber J,Taghon T,Staal FJT,Pflumio F,Six E,Cavazzana M,Lagresle-Peyrou C,Soheili T,André I
Thu Jul 01 00:00:00 EDT 2021
ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression.
Molecular cell
Lan X,Ren R,Feng R,Ly LC,Lan Y,Zhang Z,Aboreden N,Qin K,Horton JR,Grevet JD,Mayuranathan T,Abdulmalik O,Keller CA,Giardine B,Hardison RC,Crossley M,Weiss MJ,Cheng X,Shi J,Blobel GA
300-07 was used in Cell Culture to identify via a CRISPR-Cas9 genetic screen ZNF410, a pentadactyl DNA-binding protein that in human erythroid cells directly activates only a single gene, the NuRD component CHD4.
Thu Jan 21 00:00:00 EST 2021
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.
Molecular cell
Di Marcantonio D,Martinez E,Kanefsky JS,Huhn JM,Gabbasov R,Gupta A,Krais JJ,Peri S,Tan Y,Skorski T,Dorrance A,Garzon R,Goldman AR,Tang HY,Johnson N,Sykes SM
300-07 was used in In vitro experiments to investigate the role of ATF3 expression on cell cycle progression in acute myeloid leukemia.
Thu Jul 01 00:00:00 EDT 2021
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.
Science translational medicine
Reyes M,Filbin MR,Bhattacharyya RP,Sonny A,Mehta A,Billman K,Kays KR,Pinilla-Vera M,Benson ME,Cosimi LA,Hung DT,Levy BD,Villani AC,Sade-Feldman M,Baron RM,Goldberg MB,Blainey PC,Hacohen N
Wed Jun 16 00:00:00 EDT 2021
JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML.
The Journal of experimental medicine
Dagher T,Maslah N,Edmond V,Cassinat B,Vainchenker W,Giraudier S,Pasquier F,Verger E,Niwa-Kawakita M,Lallemand-Breitenbach V,Plo I,Kiladjian JJ,Villeval JL,de Thé H
Mon Feb 01 00:00:00 EST 2021
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.
The Journal of experimental medicine
Louka E,Povinelli B,Rodriguez-Meira A,Buck G,Wen WX,Wang G,Sousos N,Ashley N,Hamblin A,Booth CAG,Roy A,Elliott N,Iskander D,de la Fuente J,Fordham N,O'Byrne S,Inglott S,Norfo R,Salio M,Thongjuea S,Rao A,Roberts I,Mead AJ
Mon Feb 01 00:00:00 EST 2021
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.
The Journal of experimental medicine
Le Coz C,Nguyen DN,Su C,Nolan BE,Albrecht AV,Xhani S,Sun D,Demaree B,Pillarisetti P,Khanna C,Wright F,Chen PA,Yoon S,Stiegler AL,Maurer K,Garifallou JP,Rymaszewski A,Kroft SH,Olson TS,Seif AE,Wertheim G,Grant SFA,Vo LT,Puck JM,Sullivan KE,Routes JM,Zakharova V,Shcherbina A,Mukhina A,Rudy NL,Hurst ACE,Atkinson TP,Boggon TJ,Hakonarson H,Abate AR,Hajjar J,Nicholas SK,Lupski JR,Verbsky J,Chinn IK,Gonzalez MV,Wells AD,Marson A,Poon GMK,Romberg N
Mon Jul 05 00:00:00 EDT 2021
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.
EMBO molecular medicine
Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P
Fri Mar 05 00:00:00 EST 2021
Modeling genetic epileptic encephalopathies using brain organoids.
EMBO molecular medicine
Steinberg DJ,Repudi S,Saleem A,Kustanovich I,Viukov S,Abudiab B,Banne E,Mahajnah M,Hanna JH,Stern S,Carlen PL,Aqeilan RI
Mon Aug 09 00:00:00 EDT 2021
Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia.
Developmental cell
Ma Y,Liu S,Gao J,Chen C,Zhang X,Yuan H,Chen Z,Yin X,Sun C,Mao Y,Zhou F,Shao Y,Liu Q,Xu J,Cheng L,Yu D,Li P,Yi P,He J,Geng G,Guo Q,Si Y,Zhao H,Li H,Banes GL,Liu H,Nakamura Y,Kurita R,Huang Y,Wang X,Wang F,Fang G,Engel JD,Shi L,Zhang YE,Yu J
300-07 was used in Sample Preparation (FC/FACS) to investigate pseudogene phenotypic effects.
Mon Feb 22 00:00:00 EST 2021
Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.
Leukemia
Thomas ME,Abdelhamed S,Hiltenbrand R,Schwartz JR,Sakurada SM,Walsh M,Song G,Ma J,Pruett-Miller SM,Klco JM
Mon Nov 01 00:00:00 EDT 2021
Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling.
Molecular therapy. Nucleic acids
Kazuki Y,Uno N,Abe S,Kajitani N,Kazuki K,Yakura Y,Sawada C,Takata S,Sugawara M,Nagashima Y,Okada A,Hiratsuka M,Osaki M,Ferrari G,Tedesco FS,Nishikawa S,Fukumoto K,Takayanagi SI,Kunisato A,Kaneko S,Oshimura M,Tomizuka K
Fri Mar 05 00:00:00 EST 2021
Reducing TGF-β1 cooperated with StemRegenin 1 promoted the expansion ex vivo of cord blood CD34+ cells by inhibiting AhR signalling.
Cell proliferation
Zhu X,Sun Q,Tan WS,Cai H
Mon Mar 01 00:00:00 EST 2021
Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.
Stem cells translational medicine
Tanaka R,Ito-Hirano R,Fujimura S,Arita K,Hagiwara H,Mita T,Itoh M,Kawaji H,Ogawa T,Watada H,Masuda H,Asahara T,Mizuno H
Tue Jun 01 00:00:00 EDT 2021
Enhanced self-renewal of human long-term hematopoietic stem cells by a sulfamoyl benzoate derivative targeting p18INK4C.
Blood advances
Li Y,Zhang W,Zhang Y,Ding Y,Yang M,He M,Liu X,Gu J,Xu S,Feng Z,Li Y,Yin J,Gao H,Song H,Xu H,Wang C,Ji Q,Ma S,Yang W,Yuan W,Xie XQ,Cheng T,Gao Y
Tue Sep 14 00:00:00 EDT 2021
CRISPR-edited megakaryocytes for rapid screening of platelet gene functions.
Blood advances
Montenont E,Bhatlekar S,Jacob S,Kosaka Y,Manne BK,Lee O,Parra-Izquierdo I,Tugolukova E,Tolley ND,Rondina MT,Bray PF,Rowley JW
Tue May 11 00:00:00 EDT 2021
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency.
Blood advances
Zoccolillo M,Brigida I,Barzaghi F,Scala S,Hernández RJ,Basso-Ricci L,Colantuoni M,Pettinato E,Sergi LS,Milardi G,Capasso P,Lombardo A,Gregori S,Sanvito F,Schena F,Cesaro S,Conti F,Pession A,Benedetti F,Gattorno M,Lee PY,Naldini L,Cicalese MP,Aiuti A,Mortellaro A
Tue Aug 24 00:00:00 EDT 2021
Digestion and Transport across the Intestinal Epithelium Affects the Allergenicity of Ara h 1 and 3 but Not of Ara h 2 and 6.
Molecular nutrition & food research
Smits M,Nooijen I,Redegeld F,de Jong A,Le TM,Knulst A,Houben G,Verhoeckx K
Mon Mar 01 00:00:00 EST 2021
Human induced pluripotent stem cell-derived macrophages ameliorate liver fibrosis.
Stem cells (Dayton, Ohio)
Pouyanfard S,Meshgin N,Cruz LS,Diggle K,Hashemi H,Pham TV,Fierro M,Tamayo P,Fanjul A,Kisseleva T,Kaufman DS
Wed Dec 01 00:00:00 EST 2021
CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.
Stem cells (Dayton, Ohio)
Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM
Sat May 01 00:00:00 EDT 2021
CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.
Stem cells (Dayton, Ohio)
Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM
Sat May 01 00:00:00 EDT 2021
In vitro and in vivo detection of tunneling nanotubes in normal and pathological osteoclastogenesis involving osteoclast fusion.
Laboratory investigation; a journal of technical methods and pathology
Zhang JQ,Takahashi A,Gu JY,Zhang X,Kyumoto-Nakamura Y,Kukita A,Uehara N,Hiura H,Yamaza T,Kukita T
Wed Dec 01 00:00:00 EST 2021
A Critical Role for Na+/H+ Exchanger Regulatory Factor 1 in Modulating FcεRI-Mediated Mast Cell Activation.
Journal of immunology (Baltimore, Md. : 1950)
Kammala AK,Syed M,Yang C,Occhiuto CJ,Subramanian H
Mon Feb 01 00:00:00 EST 2021
Bortezomib suppresses self-renewal and leukemogenesis of leukemia stem cell by NF-ĸB-dependent inhibition of CDK6 in MLL-rearranged myeloid leukemia.
Journal of cellular and molecular medicine
Zhou B,Qin Y,Zhou J,Ruan J,Xiong F,Dong J,Huang X,Yu Z,Gao S
Mon Mar 01 00:00:00 EST 2021
HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells.
Stem cells international
Kwon YW,Ahn HS,Lee JW,Yang HM,Cho HJ,Kim SJ,Lee SH,Yang HM,Jang HD,Kim SJ,Kim HS
Tue Jun 08 00:00:00 EDT 2021
Generation of three induced pluripotent stem cell lines, SCVIi003-A, SCVIi004-A, SCVIi005-A, from patients with ARVD/C caused by heterozygous mutations in the PKP2 gene.
Stem cell research
Jahng JWS,Black KE,Liu L,Bae HR,Perez M,Ashley EA,Sallam K,Wu JC
300-07 was used in Cell Culture to investigate induced pluripotent stem cell generation from patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Sat May 01 00:00:00 EDT 2021
Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome.
Nature communications
Kennedy AL,Myers KC,Bowman J,Gibson CJ,Camarda ND,Furutani E,Muscato GM,Klein RH,Ballotti K,Liu S,Harris CE,Galvin A,Malsch M,Dale D,Gansner JM,Nakano TA,Bertuch A,Vlachos A,Lipton JM,Castillo P,Connelly J,Churpek J,Edwards JR,Hijiya N,Ho RH,Hofmann I,Huang JN,Keel S,Lamble A,Lau BW,Norkin M,Stieglitz E,Stock W,Walkovich K,Boettcher S,Brendel C,Fleming MD,Davies SM,Weller EA,Bahl C,Carter SL,Shimamura A,Lindsley RC
Fri Feb 26 00:00:00 EST 2021
EGR1 is a gatekeeper of inflammatory enhancers in human macrophages.
Science advances
Trizzino M,Zucco A,Deliard S,Wang F,Barbieri E,Veglia F,Gabrilovich D,Gardini A
Fri Jan 01 00:00:00 EST 2021
Identification of a class of non-conventional ER-stress-response-derived immunogenic peptides.
Cell reports
Melacarne A,Ferrari V,Tiraboschi L,Mishto M,Liepe J,Aralla M,Marconato L,Lizier M,Pozzi C,Zeira O,Penna G,Rescigno M
Tue Jul 06 00:00:00 EDT 2021
Stem-cell-derived human microglia transplanted into mouse brain to study human disease.
Nature protocols
Fattorelli N,Martinez-Muriana A,Wolfs L,Geric I,De Strooper B,Mancuso R
300-07 was used in Sample Preparation to explain the step-by-step workflow that includes in vitro microglia differentiation from human PSCs, transplantation into the mouse brain and quantitative analysis of engraftment. This approach is more optimized and more efficient approach that yields up to 80% chimerism when compared to current differentiation and xenotransplantation protocols.
Mon Feb 01 00:00:00 EST 2021
Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis.
Cancers
Masselli E,Carubbi C,Pozzi G,Percesepe A,Campanelli R,Villani L,Gobbi G,Bonomini S,Roti G,Rosti V,Massa M,Barosi G,Vitale M
300-07 was used in In vitro experiments to conclude that the identification of the role of the CCL2/CCR2 chemokine system in PMF adds a novel element to the pathophysiological picture of the disease, with clinical and therapeutic implications.
Sat May 22 00:00:00 EDT 2021
Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice.
Communications biology
Barcia Durán JG,Lu T,Houghton S,Geng F,Schreiner R,Xiang J,Rafii S,Redmond D,Lis R
Thu Mar 25 00:00:00 EDT 2021
Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis.
Nature communications
Biavasco R,Lettera E,Giannetti K,Gilioli D,Beretta S,Conti A,Scala S,Cesana D,Gallina P,Norelli M,Basso-Ricci L,Bondanza A,Cavalli G,Ponzoni M,Dagna L,Doglioni C,Aiuti A,Merelli I,Di Micco R,Montini E
Tue Jul 27 00:00:00 EDT 2021
ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma.
Cell reports
De Bacco F,Orzan F,Erriquez J,Casanova E,Barault L,Albano R,D'Ambrosio A,Bigatto V,Reato G,Patanè M,Pollo B,Kuesters G,Dell'Aglio C,Casorzo L,Pellegatta S,Finocchiaro G,Comoglio PM,Boccaccio C
Tue Jul 27 00:00:00 EDT 2021
The miR-424(322)/503 gene cluster regulates pro- versus anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling.
Cell reports
Zyulina V,Yan KK,Ju B,Schwarzenberger E,Passegger C,Tam-Amersdorfer C,Pan Q,Sconocchia T,Pollack C,Shaner B,Zebisch A,Easton J,Yu J,Silva JM,Strobl H
Tue Apr 27 00:00:00 EDT 2021
Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic.
Nature communications
Zhang X,Luo M,Dastagir SR,Nixon M,Khamhoung A,Schmidt A,Lee A,Subbiah N,McLaughlin DC,Moore CL,Gribble M,Bayhi N,Amin V,Pepi R,Pawar S,Lyford TJ,Soman V,Mellen J,Carpenter CL,Turka LA,Wickham TJ,Chen TF
Tue May 11 00:00:00 EDT 2021
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.
Science advances
Trapecar M,Wogram E,Svoboda D,Communal C,Omer A,Lungjangwa T,Sphabmixay P,Velazquez J,Schneider K,Wright CW,Mildrum S,Hendricks A,Levine S,Muffat J,Lee MJ,Lauffenburger DA,Trumper D,Jaenisch R,Griffith LG
300-07 was used in In vitro experiments to develop a mesofluidic platform technology to study gut-liver-cerebral interactions in the context of Parkinson's disease (PD).
Fri Jan 01 00:00:00 EST 2021
Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.
iScience
Zee BM,Poels KE,Yao CH,Kawabata KC,Wu G,Duy C,Jacobus WD,Senior E,Endress JE,Jambhekar A,Lovitch SB,Ma J,Dhall A,Harris IS,Blanco MA,Sykes DB,Licht JD,Weinstock DM,Melnick A,Haigis MC,Michor F,Shi Y
Fri Jun 25 00:00:00 EDT 2021
3'HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression.
eLife
Himadewi P,Wang XQD,Feng F,Gore H,Liu Y,Yu L,Kurita R,Nakamura Y,Pfeifer GP,Liu J,Zhang X
300-07 was used in Sample Preparation (FC/FACS) to suggest that genetic editing of the 3'HS1 CTCF binding site can have therapeutic implications to treat hemoglobinopathies.
Wed Sep 29 00:00:00 EDT 2021
Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy.
eLife
Simkin D,Marshall KA,Vanoye CG,Desai RR,Bustos BI,Piyevsky BN,Ortega JA,Forrest M,Robertson GL,Penzes P,Laux LC,Lubbe SJ,Millichap JJ,George AL,Kiskinis E
300-07 was used in Cell Culture to measure the functional properties of differentiated excitatory neurons in an induced pluripotent stem cell (iPSCs) and gene editing established disease model.
Fri Feb 05 00:00:00 EST 2021
Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays.
STAR protocols
Rodríguez A,Filiatrault J,Flores-Guzmán P,Mayani H,Parmar K,D'Andrea AD
300-07 was used in Cell Culture to present protocols for the isolation of human and murine HSPCs using manual and FACS-assisted techniques.
Fri Dec 17 00:00:00 EST 2021
Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays.
STAR protocols
Rodríguez A,Filiatrault J,Flores-Guzmán P,Mayani H,Parmar K,D'Andrea AD
300-07 was used in Cell Culture to present protocols for the isolation of human and murine HSPCs using manual and FACS-assisted techniques.
Fri Dec 17 00:00:00 EST 2021
Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells.
Cells
Lazki-Hagenbach P,Ali H,Sagi-Eisenberg R
300-07 was used in Cell Culture to show that the underlying mechanisms of MRGPRX2-triggered MC degranulation in either LAD-2 or RBL-MRGPRX2 cells are different from those elicited by its rodent orthologs.
Fri Feb 12 00:00:00 EST 2021
Directly reprogrammed natural killer cells for cancer immunotherapy.
Nature biomedical engineering
Kim HS,Kim JY,Seol B,Song CL,Jeong JE,Cho YS
Mon Nov 01 00:00:00 EDT 2021
The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.
Communications biology
Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S
Mon Jun 07 00:00:00 EDT 2021
NOTCH-mediated ex vivo expansion of human hematopoietic stem and progenitor cells by culture under hypoxia.
Stem cell reports
Araki D,Fu JF,Huntsman H,Cordes S,Seifuddin F,Alvarado LJ,Cheruku PS,Cash A,Traba J,Li Y,Pirooznia M,Smith RH,Larochelle A
Tue Sep 14 00:00:00 EDT 2021
Molecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds.
Scientific reports
Marx-Blümel L,Marx C,Sonnemann J,Weise F,Hampl J,Frey J,Rothenburger L,Cirri E,Rahnis N,Koch P,Groth M,Schober A,Wang ZQ,Beck JF
Wed Oct 27 00:00:00 EDT 2021
Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Cell reports
Su H,Jiang M,Senevirathne C,Aluri S,Zhang T,Guo H,Xavier-Ferrucio J,Jin S,Tran NT,Liu SM,Sun CW,Zhu Y,Zhao Q,Chen Y,Cable L,Shen Y,Liu J,Qu CK,Han X,Klug CA,Bhatia R,Chen Y,Nimer SD,Zheng YG,Iancu-Rubin C,Jin J,Deng H,Krause DS,Xiang J,Verma A,Luo M,Zhao X
Tue Jul 27 00:00:00 EDT 2021
Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia.
Nature communications
Goldfarb AN,Freeman KC,Sahu RK,Elagib KE,Holy M,Arneja A,Polanowska-Grabowska R,Gru AA,White Z,Khalil S,Kerins MJ,Ooi A,Leitinger N,Luckey CJ,Delehanty LL
Fri Mar 12 00:00:00 EST 2021
CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells.
Nature communications
Boutin J,Rosier J,Cappellen D,Prat F,Toutain J,Pennamen P,Bouron J,Rooryck C,Merlio JP,Lamrissi-Garcia I,Cullot G,Amintas S,Guyonnet-Duperat V,Ged C,Blouin JM,Richard E,Dabernat S,Moreau-Gaudry F,Bedel A
Fri Aug 13 00:00:00 EDT 2021
In vitro expansion of fetal liver hematopoietic stem cells.
Scientific reports
Bhardwaj R,Kumar L,Chhabra D,Mehra NK,Sharma A,Mohanty S,Kochupillai V
Fri Jun 04 00:00:00 EDT 2021
SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis.
Cell reports
Jung HS,Uenishi G,Park MA,Liu P,Suknuntha K,Raymond M,Choi YJ,Thomson JA,Ong IM,Slukvin II
300-07 was used in In vitro experiments to investigate the role and mechanisms of SOX17 in human pluripotent stem cells.
Tue Feb 16 00:00:00 EST 2021
CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data.
Nature communications
Amit I,Iancu O,Levy-Jurgenson A,Kurgan G,McNeill MS,Rettig GR,Allen D,Breier D,Ben Haim N,Wang Y,Anavy L,Hendel A,Yakhini Z
Mon May 24 00:00:00 EDT 2021
Higher PGD2 production by synovial mast cells from rheumatoid arthritis patients compared with osteoarthritis patients via miR-199a-3p/prostaglandin synthetase 2 axis.
Scientific reports
Mishima S,Kashiwakura JI,Toyoshima S,Sasaki-Sakamoto T,Sano Y,Nakanishi K,Matsumoto K,Okayama Y
Thu Mar 11 00:00:00 EST 2021
Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy.
Cell reports. Medicine
Li YR,Zhou Y,Kim YJ,Zhu Y,Ma F,Yu J,Wang YC,Chen X,Li Z,Zeng S,Wang X,Lee D,Ku J,Tsao T,Hardoy C,Huang J,Cheng D,Montel-Hagen A,Seet CS,Crooks GM,Larson SM,Sasine JP,Wang X,Pellegrini M,Ribas A,Kohn DB,Witte O,Wang P,Yang L
300-07 was used in In vitro experiments to investigate cancer treatment by cell-based immunotherapy.
Tue Nov 16 00:00:00 EST 2021
The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells.
Nature communications
Sharma R,Dever DP,Lee CM,Azizi A,Pan Y,Camarena J,Köhnke T,Bao G,Porteus MH,Majeti R
Wed Jan 20 00:00:00 EST 2021
Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation.
Nature communications
Georgolopoulos G,Psatha N,Iwata M,Nishida A,Som T,Yiangou M,Stamatoyannopoulos JA,Vierstra J
Tue Nov 23 00:00:00 EST 2021
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Nature communications
Velten L,Story BA,Hernández-Malmierca P,Raffel S,Leonce DR,Milbank J,Paulsen M,Demir A,Szu-Tu C,Frömel R,Lutz C,Nowak D,Jann JC,Pabst C,Boch T,Hofmann WK,Müller-Tidow C,Trumpp A,Haas S,Steinmetz LM
Mon Mar 01 00:00:00 EST 2021
Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X.
iScience
de Castro Fonseca M,de Oliveira JF,Araujo BHS,Canateli C,do Prado PFV,Amorim Neto DP,Bosque BP,Rodrigues PV,de Godoy JVP,Tostes K,Filho HVR,Nascimento AFZ,Saito A,Tonoli CCC,Batista FAH,de Oliveira PSL,Figueira AC,Souza da Costa S,Krepischi ACV,Rosenberg C,Westfahl H,da Silva AJR,Franchini KG
Fri Aug 20 00:00:00 EDT 2021
Novel culture media enhances mononuclear cells from patients with chronic limb-threatening ischemia to increase vasculogenesis and anti-inflammatory effect.
Stem cell research & therapy
Chruewkamlow N,Pruekprasert K,Phutthakunphithak P,Acharayothin O,Prapassaro T,Hongku K,Hahtapornsawan S,Puangpunngam N,Chinsakchai K,Wongwanit C,Ruangsetakit C,Sermsathanasawadi N
300-07 was used in Cell Culture to evaluate the use of Quality and Quantity culture media to culture mononuclear cells from chronic limb-threatening ischemia patients.
Tue Sep 28 00:00:00 EDT 2021
The Expression of NTAL and Its Protein Interactors Is Associated With Clinical Outcomes in Acute Myeloid Leukemia.
Molecular & cellular proteomics : MCP
Thomé CH,Ferreira GA,Pereira-Martins DA,Augusto Dos Santos G,Almeida-Silveira DR,Weinhäuser I,Antônio de Souza G,Houtsma R,Schuringa JJ,Rego EM,Faça VM
Mon Mar 21 00:00:00 EDT 2022
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.
Nature communications
Rice S,Jackson T,Crump NT,Fordham N,Elliott N,O'Byrne S,Fanego MDML,Addy D,Crabb T,Dryden C,Inglott S,Ladon D,Wright G,Bartram J,Ancliff P,Mead AJ,Halsey C,Roberts I,Milne TA,Roy A
Thu Nov 25 00:00:00 EST 2021
Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells.
Cell death & disease
Malyukova A,Ujvari D,Yektaei-Karin E,Zovko A,Madapura HS,Keszei M,Nagy N,Lotfi K,Björn N,Wallvik J,Tamai M,Nguyen TTT,Akahane K,Inukai T,Stenke L,Salamon D
Sat Sep 25 00:00:00 EDT 2021
Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector.
Molecular therapy. Methods & clinical development
Seymour BJ,Singh S,Certo HM,Sommer K,Sather BD,Khim S,Clough C,Hale M,Pangallo J,Ryu BY,Khan IF,Adair JE,Rawlings DJ
Fri Mar 12 00:00:00 EST 2021
Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia.
Scientific reports
Hofmans M,Lammens T,Depreter B,Wu Y,Erlacher M,Caye A,Cavé H,Flotho C,de Haas V,Niemeyer CM,Stary J,Van Nieuwerburgh F,Deforce D,Van Loocke W,Van Vlierberghe P,Philippé J,De Moerloose B
Tue Feb 02 00:00:00 EST 2021
The Use of Induced Pluripotent Stem Cells to Study the Effects of Adenosine Deaminase Deficiency on Human Neutrophil Development.
Frontiers in immunology
Tsui M,Min W,Ng S,Dobbs K,Notarangelo LD,Dror Y,Grunebaum E
300-07 was used in Cell Culture to study the characterization of neutrophil developmental abnormalities and the mechanisms contributing to them to demonstrate the important role of adenosine deaminase (ADA) in the development and function of neutrophils while clarifying the mechanisms responsible for the neutrophil abnormalities in ADA-deficient patients.
Mon Dec 27 00:00:00 EST 2021
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.
Nature
Palikuqi B,Nguyen DT,Li G,Schreiner R,Pellegata AF,Liu Y,Redmond D,Geng F,Lin Y,Gómez-Salinero JM,Yokoyama M,Zumbo P,Zhang T,Kunar B,Witherspoon M,Han T,Tedeschi AM,Scottoni F,Lipkin SM,Dow L,Elemento O,Xiang JZ,Shido K,Spence JR,Zhou QJ,Schwartz RE,De Coppi P,Rabbany SY,Rafii S
Tue Sep 01 00:00:00 EDT 2020
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.
Nature
Nikolaev M,Mitrofanova O,Broguiere N,Geraldo S,Dutta D,Tabata Y,Elci B,Brandenberg N,Kolotuev I,Gjorevski N,Clevers H,Lutolf MP
Tue Sep 01 00:00:00 EDT 2020
Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.
Nature genetics
Lin KH,Rutter JC,Xie A,Pardieu B,Winn ET,Bello RD,Forget A,Itzykson R,Ahn YR,Dai Z,Sobhan RT,Anderson GR,Singleton KR,Decker AE,Winter PS,Locasale JW,Crawford L,Puissant A,Wood KC
300-07 was used in Cell Culture to perform pooled CRISPR-Cas9 knockout screens in acute myeloid leukemia (AML) cells treated with various chemotherapies to map the drug-dependent genetic basis of fitness trade-offs, a concept known as antagonistic pleiotropy (AP).
Wed Apr 01 00:00:00 EDT 2020
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
Cancer cell
Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J
Mon Jul 13 00:00:00 EDT 2020
The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies.
Cancer discovery
Su A,Ling F,Vaganay C,Sodaro G,Benaksas C,Dal Bello R,Forget A,Pardieu B,Lin KH,Rutter JC,Bassil CF,Fortin G,Pasanisi J,Antony-Debré I,Alexe G,Benoist JF,Pruvost A,Pikman Y,Qi J,Schlageter MH,Micol JB,Roti G,Cluzeau T,Dombret H,Preudhomme C,Fenouille N,Benajiba L,Golan HM,Stegmaier K,Lobry C,Wood KC,Itzykson R,Puissant A
300-07 was used in Cell Culture to investigate the effects of MTHFR for its therapeutic effects on acute myeloid leukemia.
Tue Dec 01 00:00:00 EST 2020
Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo.
Blood
Tarumoto Y,Lin S,Wang J,Milazzo JP,Xu Y,Lu B,Yang Z,Wei Y,Polyanskaya S,Wunderlich M,Gray NS,Stegmaier K,Vakoc CR
Thu Jan 02 00:00:00 EST 2020
Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171.
Blood
Subramaniam A,Žemaitis K,Talkhoncheh MS,Yudovich D,Bäckström A,Debnath S,Chen J,Jain MV,Galeev R,Gaetani M,Zubarev RA,Larsson J
Thu Nov 05 00:00:00 EST 2020
Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia.
Blood
Gebru MT,Atkinson JM,Young MM,Zhang L,Tang Z,Liu Z,Lu P,Dower CM,Chen L,Annageldiyev C,Sharma A,Imamura Kawasawa Y,Zhao Z,Miller BA,Claxton DF,Wang HG
Thu Aug 27 00:00:00 EDT 2020
Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency.
Blood
Grey W,Chauhan R,Piganeau M,Huerga Encabo H,Garcia-Albornoz M,McDonald NQ,Bonnet D
Thu Nov 26 00:00:00 EST 2020
Bone marrow-derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis.
Blood
Xiao Y,van Halteren AGS,Lei X,Borst J,Steenwijk E,de Wit T,Grabowska J,Voogd R,Kemps P,Picarsic J,van den Bos C,Borst J
Thu Nov 05 00:00:00 EST 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
300-07 was used in Cell Culture to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development.
Cell stem cell
Crosse EI,Gordon-Keylock S,Rybtsov S,Binagui-Casas A,Felchle H,Nnadi NC,Kirschner K,Chandra T,Tamagno S,Webb DJ,Rossi F,Anderson RA,Medvinsky A
300-07 was used in In vitro experiments to identify secreted signals underlying human HSC development, combining spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression profiling of sorted cell populations and single cells.
Thu Nov 05 00:00:00 EST 2020
Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells.
Cell stem cell
Jones CL,Stevens BM,Pollyea DA,Culp-Hill R,Reisz JA,Nemkov T,Gehrke S,Gamboni F,Krug A,Winters A,Pei S,Gustafson A,Ye H,Inguva A,Amaya M,Minhajuddin M,Abbott D,Becker MW,DeGregori J,Smith CA,D'Alessandro A,Jordan CT
300-07 was used in Tissue/organ culture to demonstrate that elevated nicotinamide metabolism is both the mechanistic basis for ven/aza resistance and a metabolic vulnerability of R/R LSCs.
Thu Nov 05 00:00:00 EST 2020
Bruton's tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis.
The Journal of clinical investigation
Dispenza MC,Krier-Burris RA,Chhiba KD,Undem BJ,Robida PA,Bochner BS
Tue Sep 01 00:00:00 EDT 2020
IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors.
The Journal of experimental medicine
Swann JW,Koneva LA,Regan-Komito D,Sansom SN,Powrie F,Griseri T
Mon Sep 07 00:00:00 EDT 2020
HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection.
The Journal of experimental medicine
Bodda C,Reinert LS,Fruhwürth S,Richardo T,Sun C,Zhang BC,Kalamvoki M,Pohlmann A,Mogensen TH,Bergström P,Agholme L,O'Hare P,Sodeik B,Gyrd-Hansen M,Zetterberg H,Paludan SR
Mon Jul 06 00:00:00 EDT 2020
Real-Time NMR Spectroscopy for Studying Metabolism.
Angewandte Chemie (International ed. in English)
Alshamleh I,Krause N,Richter C,Kurrle N,Serve H,Günther UL,Schwalbe H
Mon Feb 03 00:00:00 EST 2020
Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation.
Allergy
Le Floc'h A,Allinne J,Nagashima K,Scott G,Birchard D,Asrat S,Bai Y,Lim WK,Martin J,Huang T,Potocky TB,Kim JH,Rafique A,Papadopoulos NJ,Stahl N,Yancopoulos GD,Murphy AJ,Sleeman MA,Orengo JM
Fri May 01 00:00:00 EDT 2020
Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy.
EMBO molecular medicine
Di Matteo F,Pipicelli F,Kyrousi C,Tovecci I,Penna E,Crispino M,Chambery A,Russo R,Ayo-Martin AC,Giordano M,Hoffmann A,Ciusani E,Canafoglia L,Götz M,Di Giaimo R,Cappello S
Mon Jun 08 00:00:00 EDT 2020
Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production.
Developmental cell
Frame JM,Kubaczka C,Long TL,Esain V,Soto RA,Hachimi M,Jing R,Shwartz A,Goessling W,Daley GQ,North TE
300-07 was used in In vitro experiments to establish the inflammasome as a conserved metabolic sensor that expands HSPC production in vivo and in vitro.
Mon Oct 26 00:00:00 EDT 2020
Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells.
Proceedings of the National Academy of Sciences of the United States of America
Huang P,Zhao Y,Zhong J,Zhang X,Liu Q,Qiu X,Chen S,Yan H,Hillyer C,Mohandas N,Pan X,Xu X
Tue Jun 09 00:00:00 EDT 2020
Efficient and nontoxic biomolecule delivery to primary human hematopoietic stem cells using nanostraws.
Proceedings of the National Academy of Sciences of the United States of America
Schmiderer L,Subramaniam A,Žemaitis K,Bäckström A,Yudovich D,Soboleva S,Galeev R,Prinz CN,Larsson J,Hjort M
Tue Sep 01 00:00:00 EDT 2020
Acoustofluidic sonoporation for gene delivery to human hematopoietic stem and progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America
Belling JN,Heidenreich LK,Tian Z,Mendoza AM,Chiou TT,Gong Y,Chen NY,Young TD,Wattanatorn N,Park JH,Scarabelli L,Chiang N,Takahashi J,Young SG,Stieg AZ,De Oliveira S,Huang TJ,Weiss PS,Jonas SJ
Tue May 19 00:00:00 EDT 2020
Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.
Proceedings of the National Academy of Sciences of the United States of America
Qiao X,van der Zanden SY,Wander DPA,Borràs DM,Song JY,Li X,van Duikeren S,van Gils N,Rutten A,van Herwaarden T,van Tellingen O,Giacomelli E,Bellin M,Orlova V,Tertoolen LGJ,Gerhardt S,Akkermans JJ,Bakker JM,Zuur CL,Pang B,Smits AM,Mummery CL,Smit L,Arens R,Li J,Overkleeft HS,Neefjes J
Tue Jun 30 00:00:00 EDT 2020
Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway.
Proceedings of the National Academy of Sciences of the United States of America
Wang T,Medynets M,Johnson KR,Doucet-O'Hare TT,DiSanza B,Li W,Xu Y,Bagnell A,Tyagi R,Sampson K,Malik N,Steiner J,Hadegan A,Kowalak J,O'Malley J,Maric D,Nath A
Tue Jul 28 00:00:00 EDT 2020
ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells.
Oncogene
Redondo Monte E,Wilding A,Leubolt G,Kerbs P,Bagnoli JW,Hartmann L,Hiddemann W,Chen-Wichmann L,Krebs S,Blum H,Cusan M,Vick B,Jeremias I,Enard W,Theurich S,Wichmann C,Greif PA
Wed Apr 01 00:00:00 EDT 2020
Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood CD34+ cells via inhibition of senescence.
Stem cells translational medicine
Li X,Ma X,Chen Y,Peng D,Wang H,Chen S,Xiao Y,Li L,Zhou H,Cheng F,Gao Y,Chang J,Cheng T,Liu L
Tue Dec 01 00:00:00 EST 2020
Regulation of ABO blood group antigen expression by miR-331-3p and miR-1908-5p during hematopoietic stem cell differentiation.
Stem cells (Dayton, Ohio)
Kronstein-Wiedemann R,Nowakowska P,Milanov P,Gubbe K,Seifried E,Bugert P,Chavakis T,Tonn T
Thu Oct 01 00:00:00 EDT 2020
EDAG mediates Hsp70 nuclear localization in erythroblasts and rescues dyserythropoiesis in myelodysplastic syndrome.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dong XM,Zhao K,Zheng WW,Xu CW,Zhang MJ,Yin RH,Gao R,Tang LJ,Liu JF,Chen H,Zhan YQ,Yu M,Ge CH,Gao HY,Li X,Luo T,Ning HM,Yang XM,Li CY
Mon Jun 01 00:00:00 EDT 2020
Good Manufacturing Practice-Grade of Megakaryocytes Produced by a Novel Ex Vivo Culturing Platform.
Clinical and translational science
Guan X,Wang L,Wang H,Wang H,Dai W,Jiang Y
Sun Nov 01 00:00:00 EDT 2020
MRGPRX2 activation as a rapid, high-throughput mechanistic-based approach for detecting peptide-mediated human mast cell degranulation liabilities.
Journal of immunotoxicology
Lafleur MA,Werner J,Fort M,Lobenhofer EK,Balazs M,Goyos A
300-07 was used in Sample Preparation (FC/FACS) to investigate the use of assessing MRGPRX2 activation in engineered cells in screening for mast cell degranulation for peptide-based therapeutics.
Tue Dec 01 00:00:00 EST 2020
Ex vivo editing of human hematopoietic stem cells for erythroid expression of therapeutic proteins.
Nature communications
Pavani G,Laurent M,Fabiano A,Cantelli E,Sakkal A,Corre G,Lenting PJ,Concordet JP,Toueille M,Miccio A,Amendola M
Wed Jul 29 00:00:00 EDT 2020
Targeted gene correction of human hematopoietic stem cells for the treatment of Wiskott - Aldrich Syndrome.
Nature communications
Rai R,Romito M,Rivers E,Turchiano G,Blattner G,Vetharoy W,Ladon D,Andrieux G,Zhang F,Zinicola M,Leon-Rico D,Santilli G,Thrasher AJ,Cavazza A
Wed Aug 12 00:00:00 EDT 2020
Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.
Nature communications
Leonards K,Almosailleakh M,Tauchmann S,Bagger FO,Thirant C,Juge S,Bock T,Méreau H,Bezerra MF,Tzankov A,Ivanek R,Losson R,Peters AHFM,Mercher T,Schwaller J
Fri Jun 12 00:00:00 EDT 2020
Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation.
Communications biology
Yao Y,Yang J,Qin Q,Tang C,Li Z,Chen L,Li K,Ren C,Chen L,Rao S
Fri Dec 18 00:00:00 EST 2020
Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential.
Stem cell reports
Lange L,Hoffmann D,Schwarzer A,Ha TC,Philipp F,Lenz D,Morgan M,Schambach A
Tue Jan 14 00:00:00 EST 2020
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Nature communications
Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ
300-07 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.
Fri Dec 04 00:00:00 EST 2020
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Nature communications
Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ
300-07 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.
Fri Dec 04 00:00:00 EST 2020
Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression.
Cell reports
Rexach JE,Polioudakis D,Yin A,Swarup V,Chang TS,Nguyen T,Sarkar A,Chen L,Huang J,Lin LC,Seeley W,Trojanowski JQ,Malhotra D,Geschwind DH
300-07 was used in In vitro experiments to investigate gene analysis in neurodegenerative diseases.
Tue Nov 17 00:00:00 EST 2020
In vivo non-invasive staining-free visualization of dermal mast cells in healthy, allergy and mastocytosis humans using two-photon fluorescence lifetime imaging.
Scientific reports
Kröger M,Scheffel J,Nikolaev VV,Shirshin EA,Siebenhaar F,Schleusener J,Lademann J,Maurer M,Darvin ME
Thu Sep 10 00:00:00 EDT 2020
Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling.
Cell reports
Sinha S,Biswas M,Chatterjee SS,Kumar S,Sengupta A
300-07 was used in Cell Culture to study the molecular integration of developmental signaling with mesenchymal-stromal-cell (MSC) intrinsic chromatin regulation. To reveal a link illustrating epi-genomic feedforward control of bone morphogenic protein (BMP)/transforming growth factor β (TGF-β) signaling to transcriptional and cellular plasticity in the mesenchymal microenvironment and account for stromal-SWI/SNF in hematopoiesis.
Tue Apr 28 00:00:00 EDT 2020
Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia.
STAR protocols
Ryan SK,Jordan-Sciutto KL,Anderson SA
Fri Dec 18 00:00:00 EST 2020
DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes.
Cell death & disease
Johnson DC,Okondo MC,Orth EL,Rao SD,Huang HC,Ball DP,Bachovchin DA
Fri Aug 14 00:00:00 EDT 2020
Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells.
Clinical & translational immunology
Pearson FE,Tullett KM,Leal-Rojas IM,Haigh OL,Masterman KA,Walpole C,Bridgeman JS,McLaren JE,Ladell K,Miners K,Llewellyn-Lacey S,Price DA,Tunger A,Schmitz M,Miles JJ,Lahoud MH,Radford KJ
Fri Apr 15 00:00:00 EDT 2022
Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype.
Nature communications
Thornton N,Karamatic Crew V,Tilley L,Green CA,Tay CL,Griffiths RE,Singleton BK,Spring F,Walser P,Alattar AG,Jones B,Laundy R,Storry JR,Möller M,Wall L,Charlewood R,Westhoff CM,Lomas-Francis C,Yahalom V,Feick U,Seltsam A,Mayer B,Olsson ML,Anstee DJ
Thu Jul 16 00:00:00 EDT 2020
Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy.
Scientific reports
Lázaro-Gorines R,López-Rodríguez JC,Benedé S,González M,Mayorga C,Vogel L,Martínez-Del-Pozo Á,Lacadena J,Villalba M
Thu Jul 23 00:00:00 EDT 2020
Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy.
Scientific reports
Lázaro-Gorines R,López-Rodríguez JC,Benedé S,González M,Mayorga C,Vogel L,Martínez-Del-Pozo Á,Lacadena J,Villalba M
Thu Jul 23 00:00:00 EDT 2020
Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy.
Scientific reports
Lázaro-Gorines R,López-Rodríguez JC,Benedé S,González M,Mayorga C,Vogel L,Martínez-Del-Pozo Á,Lacadena J,Villalba M
Thu Jul 23 00:00:00 EDT 2020
Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts.
Bio-protocol
Chen IP
300-07 was used in Cell Culture to study efficient differentiation of hiPSCs into osteoclasts using a three-stage protocol which does not require a co-culture system; induces EBs into mesoderm differentiation in a homogenous manner; uses less cytokines for differentiation; requires only a short time for osteoclast maturation and produces sufficient numbers of osteoclasts for subsequent molecular analyses.
Sun Dec 20 00:00:00 EST 2020
Mast Cell Activation Test (MAT).
Methods in molecular biology (Clifton, N.J.)
Bahri R,Bulfone-Paus S
300-07 was used in In vitro experiments to describe the use of the mast cell activation test (MAT) that makes use of human primary MCs generated from peripheral blood progenitors, sensitized overnight with patients' sera and activated with allergens.
Fri Feb 26 00:00:00 EST 2021
Increasing CRISPR Efficiency and Measuring Its Specificity in HSPCs Using a Clinically Relevant System.
Molecular therapy. Methods & clinical development
Shapiro J,Iancu O,Jacobi AM,McNeill MS,Turk R,Rettig GR,Amit I,Tovin-Recht A,Yakhini Z,Behlke MA,Hendel A
Fri Jun 12 00:00:00 EDT 2020
Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.
Nature communications
Araki R,Hoki Y,Suga T,Obara C,Sunayama M,Imadome K,Fujita M,Kamimura S,Nakamura M,Wakayama S,Nagy A,Wakayama T,Abe M
Fri Jan 10 00:00:00 EST 2020
Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-γ Responsive Pathway.
Cells
Haake K,Neehus AL,Buchegger T,Kühnel MP,Blank P,Philipp F,Oleaga-Quintas C,Schulz A,Grimley M,Goethe R,Jonigk D,Kalinke U,Boisson-Dupuis S,Casanova JL,Bustamante J,Lachmann N
300-07 was used in In vitro experiments to report a disease modeling platform to study the role of macrophages in patients with inborn errors of IFN-γ immunity.
Wed Feb 19 00:00:00 EST 2020
Human mast cells exhibit an individualized pattern of antimicrobial responses.
Immunity, inflammation and disease
Garcia-Rodriguez KM,Bahri R,Sattentau C,Roberts IS,Goenka A,Bulfone-Paus S
Mon Jun 01 00:00:00 EDT 2020
Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V.
Nature communications
Rai S,Tanaka H,Suzuki M,Espinoza JL,Kumode T,Tanimura A,Yokota T,Oritani K,Watanabe T,Kanakura Y,Matsumura I
Tue Aug 18 00:00:00 EDT 2020
Establishment of a Long-Term Co-culture Assay for Mesenchymal Stromal Cells and Hematopoietic Stem/Progenitors.
STAR protocols
Sinha S,Chakraborty S,Sengupta A
Fri Dec 18 00:00:00 EST 2020
The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.
Immunity
Mintz MA,Felce JH,Chou MY,Mayya V,Xu Y,Shui JW,An J,Li Z,Marson A,Okada T,Ware CF,Kronenberg M,Dustin ML,Cyster JG
Tue Aug 20 00:00:00 EDT 2019
Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos.
Immunity
Zeng Y,Liu C,Gong Y,Bai Z,Hou S,He J,Bian Z,Li Z,Ni Y,Yan J,Huang T,Shi H,Ma C,Chen X,Wang J,Bian L,Lan Y,Liu B,Hu H
Tue Nov 19 00:00:00 EST 2019
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Cancer cell
Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG
300-07 was used in Cell Culture to show that FTO is a druggable target and that targeting FTO by small-molecule inhibitors holds potential to treat AML.
Mon Apr 15 00:00:00 EDT 2019
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Cancer cell
Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG
300-07 was used in Cell Culture to show that FTO is a druggable target and that targeting FTO by small-molecule inhibitors holds potential to treat AML.
Mon Apr 15 00:00:00 EDT 2019
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Cancer cell
Labuhn M,Perkins K,Matzk S,Varghese L,Garnett C,Papaemmanuil E,Metzner M,Kennedy A,Amstislavskiy V,Risch T,Bhayadia R,Samulowski D,Hernandez DC,Stoilova B,Iotchkova V,Oppermann U,Scheer C,Yoshida K,Schwarzer A,Taub JW,Crispino JD,Weiss MJ,Hayashi Y,Taga T,Ito E,Ogawa S,Reinhardt D,Yaspo ML,Campbell PJ,Roberts I,Constantinescu SN,Vyas P,Heckl D,Klusmann JH
Mon Aug 12 00:00:00 EDT 2019
Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.
Nature immunology
Cella M,Gamini R,Sécca C,Collins PL,Zhao S,Peng V,Robinette ML,Schettini J,Zaitsev K,Gordon W,Bando JK,Yomogida K,Cortez V,Fronick C,Fulton R,Lin LL,Gilfillan S,Flavell RA,Shan L,Artyomov MN,Bowman M,Oltz EM,Jelinsky SA,Colonna M
300-07 was used in In vitro experiments to demonstrate that innate lymphoid cells (ILCs) undergo conversion from ILC3s into ILC1-like cells in human tissues in vivo, requiring tissue factors and Aiolos in the process.
Thu Aug 01 00:00:00 EDT 2019
PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia-initiating cells.
Blood
Hu T,Morita K,Hill MC,Jiang Y,Kitano A,Saito Y,Wang F,Mao X,Hoegenauer KA,Morishita K,Martin JF,Futreal PA,Takahashi K,Nakada D
Thu Aug 15 00:00:00 EDT 2019
Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.
Blood
Alvarado LJ,Huntsman HD,Cheng H,Townsley DM,Winkler T,Feng X,Dunbar CE,Young NS,Larochelle A
Thu May 09 00:00:00 EDT 2019
Germline mutations in the transcription factor IKZF5 cause thrombocytopenia.
Blood
Lentaigne C,Greene D,Sivapalaratnam S,Favier R,Seyres D,Thys C,Grassi L,Mangles S,Sibson K,Stubbs M,Burden F,Bordet JC,Armari-Alla C,Erber W,Farrow S,Gleadall N,Gomez K,Megy K,Papadia S,Penkett CJ,Sims MC,Stefanucci L,Stephens JC,Read RJ,Stirrups KE,Ouwehand WH,Laffan MA,Frontini M,Freson K,Turro E
Thu Dec 05 00:00:00 EST 2019
Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes.
Blood
Hsu J,Reilly A,Hayes BJ,Clough CA,Konnick EQ,Torok-Storb B,Gulsuner S,Wu D,Becker PS,Keel SB,Abkowitz JL,Doulatov S
Thu Jul 11 00:00:00 EDT 2019
Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.
Cell stem cell
Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Macabali MH,Gjertson D,Wang X,Galic Z,Kitchen SG,An DS,Hu-Lieskovan S,Kaplan-Lefko PJ,De Oliveira SN,Seet CS,Larson SM,Forman SJ,Heath JR,Zack JA,Crooks GM,Radu CG,Ribas A,Kohn DB,Witte ON,Yang L
300-07 was used in In vitro experiments to develop a proof-of-concept for hematopoietic stem cell-engineered invariant natural killer T (iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient's lifetime.
Thu Oct 03 00:00:00 EDT 2019
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.
The Journal of clinical investigation
Chan LC,Li CW,Xia W,Hsu JM,Lee HH,Cha JH,Wang HL,Yang WH,Yen EY,Chang WC,Zha Z,Lim SO,Lai YJ,Liu C,Liu J,Dong Q,Yang Y,Sun L,Wei Y,Nie L,Hsu JL,Li H,Ye Q,Hassan MM,Amin HM,Kaseb AO,Lin X,Wang SC,Hung MC
Mon Jul 15 00:00:00 EDT 2019
Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations.
Molecular cell
Gothe HJ,Bouwman BAM,Gusmao EG,Piccinno R,Petrosino G,Sayols S,Drechsel O,Minneker V,Josipovic N,Mizi A,Nielsen CF,Wagner EM,Takeda S,Sasanuma H,Hudson DF,Kindler T,Baranello L,Papantonis A,Crosetto N,Roukos V
300-07 was used in Cell Culture to propose that transcription and 3D chromosome folding jointly pose a threat to genomic stability and are key contributors to the occurrence of genome rearrangements that drive cancer.
Thu Jul 25 00:00:00 EDT 2019
Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response.
Science translational medicine
Sharon D,Cathelin S,Mirali S,Di Trani JM,Yanofsky DJ,Keon KA,Rubinstein JL,Schimmer AD,Ketela T,Chan SM
300-07 was used in Cell Culture to investigate if inactivation of genes involved in mitochondrial translation restores sensitivity to venetoclax in resistant acute myeloid leukemia cells.
Wed Oct 30 00:00:00 EDT 2019
A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain.
Neuron
Green DP,Limjunyawong N,Gour N,Pundir P,Dong X
Wed Feb 06 00:00:00 EST 2019
Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR.
The Journal of experimental medicine
Deng M,Guo H,Tam JW,Johnson BM,Brickey WJ,New JS,Lenox A,Shi H,Golenbock DT,Koller BH,McKinnon KP,Beutler B,Ting JP
Mon Dec 02 00:00:00 EST 2019
Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity.
The Journal of allergy and clinical immunology
Klein O,Krier-Burris RA,Lazki-Hagenbach P,Gorzalczany Y,Mei Y,Ji P,Bochner BS,Sagi-Eisenberg R
300-07 was used in Cell Culture to identify mDia1 as a novel regulator of MC response that coordinates MC chemotaxis and secretion through its actin-nucleating activity.
Tue Oct 01 00:00:00 EDT 2019
NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia.
Leukemia
Lopez-Millan B,Sanchéz-Martínez D,Roca-Ho H,Gutiérrez-Agüera F,Molina O,Diaz de la Guardia R,Torres-Ruiz R,Fuster JL,Ballerini P,Suessbier U,Nombela-Arrieta C,Bueno C,Menéndez P
Mon Jul 01 00:00:00 EDT 2019
Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair.
Oncogene
Seoane M,Buhs S,Iglesias P,Strauss J,Puller AC,Müller J,Gerull H,Feldhaus S,Alawi M,Brandner JM,Eggert D,Du J,Thomale J,Wild PJ,Zimmermann M,Sternsdorf T,Schumacher U,Nollau P,Fisher DE,Horstmann MA
Wed May 01 00:00:00 EDT 2019
Enabling Large-Scale Ex Vivo Production of Megakaryocytes from CD34+ Cells Using Gas-Permeable Surfaces.
Stem cells translational medicine
Martinez AF,Miller WM
Mon Jul 01 00:00:00 EDT 2019
Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair.
Stem cells (Dayton, Ohio)
Lomova A,Clark DN,Campo-Fernandez B,Flores-Bjurström C,Kaufman ML,Fitz-Gibbon S,Wang X,Miyahira EY,Brown D,DeWitt MA,Corn JE,Hollis RP,Romero Z,Kohn DB
Fri Feb 01 00:00:00 EST 2019
Paracrine Factors Released by Osteoblasts Provide Strong Platelet Engraftment Properties.
Stem cells (Dayton, Ohio)
Abu-Khader A,Law KW,Jahan S,Manesia JK,Pasha R,Hovey O,Pineault N
Fri Mar 01 00:00:00 EST 2019
Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.
Journal of immunology (Baltimore, Md. : 1950)
Stephenson S,Care MA,Fan I,Zougman A,Westhead DR,Doody GM,Tooze RM
Fri Feb 15 00:00:00 EST 2019
Efficient gene correction of an aberrant splice site in β-thalassaemia iPSCs by CRISPR/Cas9 and single-strand oligodeoxynucleotides.
Journal of cellular and molecular medicine
Xiong Z,Xie Y,Yang Y,Xue Y,Wang D,Lin S,Chen D,Lu D,He L,Song B,Yang Y,Sun X
Sun Dec 01 00:00:00 EST 2019
Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell reports
Aho ER,Wang J,Gogliotti RD,Howard GC,Phan J,Acharya P,Macdonald JD,Cheng K,Lorey SL,Lu B,Wenzel S,Foshage AM,Alvarado J,Wang F,Shaw JG,Zhao B,Weissmiller AM,Thomas LR,Vakoc CR,Hall MD,Hiebert SW,Liu Q,Stauffer SR,Fesik SW,Tansey WP
300-07 was used in Cell Culture to identify WIN site inhibitors and demonstrate that the WIN site links WDR5 to chromatin at a small cohort of loci, including a specific subset of ribosome protein genes.
Tue Mar 12 00:00:00 EDT 2019
Vitamin C-dependent lysine demethylase 6 (KDM6)-mediated demethylation promotes a chromatin state that supports the endothelial-to-hematopoietic transition.
The Journal of biological chemistry
Zhang T,Huang K,Zhu Y,Wang T,Shan Y,Long B,Li Y,Chen Q,Wang P,Zhao S,Li D,Wu C,Kang B,Gu J,Mai Y,Wang Q,Li J,Zhang Y,Liang Z,Guo L,Wu F,Su S,Wang J,Gao M,Zhong X,Liao B,Chen J,Zhang X,Shu X,Pei D,Nie J,Pan G
Fri Sep 13 00:00:00 EDT 2019
Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis.
Cell reports
Ludwig LS,Lareau CA,Bao EL,Nandakumar SK,Muus C,Ulirsch JC,Chowdhary K,Buenrostro JD,Mohandas N,An X,Aryee MJ,Regev A,Sankaran VG
300-07 was used in Cell Culture to apply deep transcriptomic and accessible chromatin profiling to characterize a faithful ex vivo human erythroid differentiation system from hematopoietic stem and progenitor cells.
Tue Jun 11 00:00:00 EDT 2019
Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index.
Scientific reports
Li Y,Thomas D,Deutzmann A,Majeti R,Felsher DW,Dill DL
Thu Nov 14 00:00:00 EST 2019
A comprehensive single cell transcriptional landscape of human hematopoietic progenitors.
Nature communications
Pellin D,Loperfido M,Baricordi C,Wolock SL,Montepeloso A,Weinberg OK,Biffi A,Klein AM,Biasco L
Mon Jun 03 00:00:00 EDT 2019
Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice.
Scientific reports
Radtke S,Görgens A,da Conceição Castro SV,Kordelas L,Köninger A,Dürig J,Möllmann M,Horn PA,Giebel B
Mon Sep 09 00:00:00 EDT 2019
A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer.
Cell death & disease
Mazzoldi EL,Pavan S,Pilotto G,Leone K,Pagotto A,Frezzini S,Nicoletto MO,Amadori A,Pastò A
Tue May 28 00:00:00 EDT 2019
Cytokine Selection of MSC Clones with Different Functionality.
Stem cell reports
Selich A,Ha TC,Morgan M,Falk CS,von Kaisenberg C,Schambach A,Rothe M
Tue Aug 13 00:00:00 EDT 2019
All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.
Cell death & disease
Nguyen CH,Bauer K,Hackl H,Schlerka A,Koller E,Hladik A,Stoiber D,Zuber J,Staber PB,Hoelbl-Kovacic A,Purton LE,Grebien F,Wieser R
Tue Dec 10 00:00:00 EST 2019
Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome.
Cell stem cell
Masiuk KE,Laborada J,Roncarolo MG,Hollis RP,Kohn DB
300-07 was used in Cell Culture to demonstrate preclinical efficacy for the treatment of IPEX patients by autologous HSC transplant and may provide valuable insights into new cell therapies for autoimmunity.
Thu Feb 07 00:00:00 EST 2019
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.
Nature communications
Kusakabe M,Sun AC,Tyshchenko K,Wong R,Nanda A,Shanna C,Gusscott S,Chavez EA,Lorzadeh A,Zhu A,Hill A,Hung S,Brown S,Babaian A,Wang X,Holt RA,Steidl C,Karsan A,Humphries RK,Eaves CJ,Hirst M,Weng AP
Tue Jul 02 00:00:00 EDT 2019
UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells.
Scientific reports
Mesquitta WT,Wandsnider M,Kang H,Thomson J,Moskvin O,Suknuntha K,Slukvin II
Mon Apr 29 00:00:00 EDT 2019
Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo.
Stem cell reports
Easterbrook J,Rybtsov S,Gordon-Keylock S,Ivanovs A,Taoudi S,Anderson RA,Medvinsky A
Tue May 14 00:00:00 EDT 2019
Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.
Nature communications
Wang Y,Lu T,Sun G,Zheng Y,Yang S,Zhang H,Hao S,Liu Y,Ma S,Zhang H,Ru Y,Gao S,Yen K,Cheng H,Cheng T
Fri Dec 06 00:00:00 EST 2019
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
Nature medicine
Johnson DC,Taabazuing CY,Okondo MC,Chui AJ,Rao SD,Brown FC,Reed C,Peguero E,de Stanchina E,Kentsis A,Bachovchin DA
300-07 was used in Cell Culture to identify an activator of CARD8 in human cells and indicate that its activation by small-molecule DPP8/9 inhibitors represents a new potential therapeutic strategy for AML.
Wed Aug 01 00:00:00 EDT 2018
Regulation of embryonic haematopoietic multipotency by EZH1.
Nature
Vo LT,Kinney MA,Liu X,Zhang Y,Barragan J,Sousa PM,Jha DK,Han A,Cesana M,Shao Z,North TE,Orkin SH,Doulatov S,Xu J,Daley GQ
Thu Jan 25 00:00:00 EST 2018
Identification of the Human Skeletal Stem Cell.
Cell
Chan CKF,Gulati GS,Sinha R,Tompkins JV,Lopez M,Carter AC,Ransom RC,Reinisch A,Wearda T,Murphy M,Brewer RE,Koepke LS,Marecic O,Manjunath A,Seo EY,Leavitt T,Lu WJ,Nguyen A,Conley SD,Salhotra A,Ambrosi TH,Borrelli MR,Siebel T,Chan K,Schallmoser K,Seita J,Sahoo D,Goodnough H,Bishop J,Gardner M,Majeti R,Wan DC,Goodman S,Weissman IL,Chang HY,Longaker MT
Thu Sep 20 00:00:00 EDT 2018
Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.
Cell
Khajuria RK,Munschauer M,Ulirsch JC,Fiorini C,Ludwig LS,McFarland SK,Abdulhay NJ,Specht H,Keshishian H,Mani DR,Jovanovic M,Ellis SR,Fulco CP,Engreitz JM,Schütz S,Lian J,Gripp KW,Weinberg OK,Pinkus GS,Gehrke L,Regev A,Lander ES,Gazda HT,Lee WY,Panse VG,Carr SA,Sankaran VG
Thu Mar 22 00:00:00 EDT 2018
CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.
Cell
Pulikkan JA,Hegde M,Ahmad HM,Belaghzal H,Illendula A,Yu J,O'Hagan K,Ou J,Muller-Tidow C,Wolfe SA,Zhu LJ,Dekker J,Bushweller JH,Castilla LH
300-07 was used in In vitro experiments to study the mechanism for the ways in which CBFβ-SMMHC drives leukemia maintenance and show that inhibitors targeting chromatin activity may prove effective in inv(16) leukemia therapy.
Thu Jun 28 00:00:00 EDT 2018
Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells.
Cell
Guzzi N,Cieśla M,Ngoc PCT,Lang S,Arora S,Dimitriou M,Pimková K,Sommarin MNE,Munita R,Lubas M,Lim Y,Okuyama K,Soneji S,Karlsson G,Hansson J,Jönsson G,Lund AH,Sigvardsson M,Hellström-Lindberg E,Hsieh AC,Bellodi C
Thu May 17 00:00:00 EDT 2018
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.
Cell
Su R,Dong L,Li C,Nachtergaele S,Wunderlich M,Qing Y,Deng X,Wang Y,Weng X,Hu C,Yu M,Skibbe J,Dai Q,Zou D,Wu T,Yu K,Weng H,Huang H,Ferchen K,Qin X,Zhang B,Qi J,Sasaki AT,Plas DR,Bradner JE,Wei M,Marcucci G,Jiang X,Mulloy JC,Jin J,He C,Chen J
Thu Jan 11 00:00:00 EST 2018
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Cell
Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM
Thu Jan 25 00:00:00 EST 2018
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Cell
Kim MY,Yu KR,Kenderian SS,Ruella M,Chen S,Shin TH,Aljanahi AA,Schreeder D,Klichinsky M,Shestova O,Kozlowski MS,Cummins KD,Shan X,Shestov M,Bagg A,Morrissette JJD,Sekhri P,Lazzarotto CR,Calvo KR,Kuhns DB,Donahue RE,Behbehani GK,Tsai SQ,Dunbar CE,Gill S
Thu May 31 00:00:00 EDT 2018
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Cell
Kim MY,Yu KR,Kenderian SS,Ruella M,Chen S,Shin TH,Aljanahi AA,Schreeder D,Klichinsky M,Shestova O,Kozlowski MS,Cummins KD,Shan X,Shestov M,Bagg A,Morrissette JJD,Sekhri P,Lazzarotto CR,Calvo KR,Kuhns DB,Donahue RE,Behbehani GK,Tsai SQ,Dunbar CE,Gill S
Thu May 31 00:00:00 EDT 2018
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
Cancer cell
Jones CL,Stevens BM,D'Alessandro A,Reisz JA,Culp-Hill R,Nemkov T,Pei S,Khan N,Adane B,Ye H,Krug A,Reinhold D,Smith C,DeGregori J,Pollyea DA,Jordan CT
Mon Nov 12 00:00:00 EST 2018
Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation.
Blood
Li Y,Jin C,Bai H,Gao Y,Sun S,Chen L,Qin L,Liu PP,Cheng L,Wang QF
Thu Jan 11 00:00:00 EST 2018
IGF-1 facilitates thrombopoiesis primarily through Akt activation.
Blood
Chen S,Hu M,Shen M,Wang S,Wang C,Chen F,Tang Y,Wang X,Zeng H,Chen M,Gao J,Wang F,Su Y,Xu Y,Wang J
Thu Jul 12 00:00:00 EDT 2018
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.
Cell stem cell
Petrillo C,Thorne LG,Unali G,Schiroli G,Giordano AMS,Piras F,Cuccovillo I,Petit SJ,Ahsan F,Noursadeghi M,Clare S,Genovese P,Gentner B,Naldini L,Towers GJ,Kajaste-Rudnitski A
300-07 was used in In vitro experiments to report on the involvement of innate pathogen recognition molecules in immune blocks to gene correction in primary human hematopoietic stem cells.
Thu Dec 06 00:00:00 EST 2018
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.
Cell stem cell
Petrillo C,Thorne LG,Unali G,Schiroli G,Giordano AMS,Piras F,Cuccovillo I,Petit SJ,Ahsan F,Noursadeghi M,Clare S,Genovese P,Gentner B,Naldini L,Towers GJ,Kajaste-Rudnitski A
300-07 was used in In vitro experiments to report on the involvement of innate pathogen recognition molecules in immune blocks to gene correction in primary human hematopoietic stem cells.
Thu Dec 06 00:00:00 EST 2018
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
The Journal of clinical investigation
Chennupati V,Veiga DF,Maslowski KM,Andina N,Tardivel A,Yu EC,Stilinovic M,Simillion C,Duchosal MA,Quadroni M,Roberts I,Sankaran VG,MacDonald HR,Fasel N,Angelillo-Scherrer A,Schneider P,Hoang T,Allam R
Mon Apr 02 00:00:00 EDT 2018
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
The Journal of clinical investigation
Chennupati V,Veiga DF,Maslowski KM,Andina N,Tardivel A,Yu EC,Stilinovic M,Simillion C,Duchosal MA,Quadroni M,Roberts I,Sankaran VG,MacDonald HR,Fasel N,Angelillo-Scherrer A,Schneider P,Hoang T,Allam R
Mon Apr 02 00:00:00 EDT 2018
JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling.
The Journal of clinical investigation
Zhang Y,Xia F,Liu X,Yu Z,Xie L,Liu L,Chen C,Jiang H,Hao X,He X,Zhang F,Gu H,Zhu J,Bai H,Zhang CC,Chen GQ,Zheng J
Tue May 01 00:00:00 EDT 2018
PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature.
The Journal of clinical investigation
Corrigan DJ,Luchsinger LL,Justino de Almeida M,Williams LJ,Strikoudis A,Snoeck HW
Wed Aug 01 00:00:00 EDT 2018
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
The Journal of experimental medicine
Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW
Mon Mar 05 00:00:00 EST 2018
Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.
The Journal of experimental medicine
Khalil S,Delehanty L,Grado S,Holy M,White Z,Freeman K,Kurita R,Nakamura Y,Bullock G,Goldfarb A
Mon Feb 05 00:00:00 EST 2018
The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.
The Journal of allergy and clinical immunology
Li Y,Liu B,Harmacek L,Long Z,Liang J,Lukin K,Leach SM,O'Connor B,Gerber AN,Hagman J,Roers A,Finkelman FD,Huang H
300-07 was used in Cell Culture to conclude that the transcription factors GATA2 and MITF regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.
Mon Oct 01 00:00:00 EDT 2018
Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies.
Clinical cancer research : an official journal of the American Association for Cancer Research
L'Italien L,Orozco O,Abrams T,Cantagallo L,Connor A,Desai J,Ebersbach H,Gelderblom H,Hoffmaster K,Lees E,Maacke H,Schleyer S,Skegro D,Lee-Hoeflich ST
300-07 was used in In vitro experiments to identifying potential mitigation strategies in hypersensitivity reactions.
Sun Jul 15 00:00:00 EDT 2018
A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.
Developmental cell
Böiers C,Richardson SE,Laycock E,Zriwil A,Turati VA,Brown J,Wray JP,Wang D,James C,Herrero J,Sitnicka E,Karlsson S,Smith AJH,Jacobsen SEW,Enver T
300-07 was used in Cell Culture to explore the link between embryonic B-myeloid fate restriction and ETV6-RUNX1 mutant acute B-lymphoblastic leukaemia development.
Mon Feb 05 00:00:00 EST 2018
Rhinovirus induces an anabolic reprogramming in host cell metabolism essential for viral replication.
Proceedings of the National Academy of Sciences of the United States of America
Gualdoni GA,Mayer KA,Kapsch AM,Kreuzberg K,Puck A,Kienzl P,Oberndorfer F,Frühwirth K,Winkler S,Blaas D,Zlabinger GJ,Stöckl J
Tue Jul 24 00:00:00 EDT 2018
Efficient generation of functional haploid spermatids from human germline stem cells by three-dimensional-induced system.
Cell death and differentiation
Sun M,Yuan Q,Niu M,Wang H,Wen L,Yao C,Hou J,Chen Z,Fu H,Zhou F,Li C,Gao S,Gao WQ,Li Z,He Z
Thu Mar 01 00:00:00 EST 2018
Rapid and Efficient Production of Human Functional Mast Cells through a Three-Dimensional Culture of Adipose Tissue-Derived Stromal Vascular Cells.
Journal of immunology (Baltimore, Md. : 1950)
Paupert J,Espinosa E,Cenac N,Robert V,Laharrague P,Evrard SM,Casteilla L,Lorsignol A,Cousin B
Sat Dec 15 00:00:00 EST 2018
MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1.
Stem cell reports
Wang H,Liu C,Liu X,Wang M,Wu D,Gao J,Su P,Nakahata T,Zhou W,Xu Y,Shi L,Ma F,Zhou J
Tue Feb 13 00:00:00 EST 2018
Preserving self-renewal of porcine pluripotent stem cells in serum-free 3i culture condition and independent of LIF and b-FGF cytokines.
Cell death discovery
Ma Y,Yu T,Cai Y,Wang H
Sat Dec 01 00:00:00 EST 2018
Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis.
Cell reports
Osorio FG,Rosendahl Huber A,Oka R,Verheul M,Patel SH,Hasaart K,de la Fonteijne L,Varela I,Camargo FD,van Boxtel R
300-07 was used in Sample Preparation (FC/FACS) to perform genomic analysis of the mutation accumulation of HSPCs.
Tue Nov 27 00:00:00 EST 2018
NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
Nature communications
Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II
Tue May 08 00:00:00 EDT 2018
Robust CRISPR/Cas9 Genome Editing of the HUDEP-2 Erythroid Precursor Line Using Plasmids and Single-Stranded Oligonucleotide Donors.
Methods and protocols
Moir-Meyer G,Cheong PL,Olijnik AA,Brown J,Knight S,King A,Kurita R,Nakamura Y,Gibbons RJ,Higgs DR,Buckle VJ,Babbs C
300-07 was used in Cell Culture to produce genetically modified lines in ~30 days and could also be used to generate knock-out and knock-in mutations.
Mon Jul 30 00:00:00 EDT 2018
P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim.
Nature communications
Hu P,Nebreda AR,Hanenberg H,Kinnebrew GH,Ivan M,Yoder MC,Filippi MD,Broxmeyer HE,Kapur R
Wed Aug 29 00:00:00 EDT 2018
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.
The Journal of biological chemistry
Seren S,Rashed Abouzaid M,Eulenberg-Gustavus C,Hirschfeld J,Nasr Soliman H,Jerke U,N'Guessan K,Dallet-Choisy S,Lesner A,Lauritzen C,Schacher B,Eickholz P,Nagy N,Szell M,Croix C,Viaud-Massuard MC,Al Farraj Aldosari A,Ragunatha S,Ibrahim Mostafa M,Giampieri F,Battino M,Cornillier H,Lorette G,Stephan JL,Goizet C,Pedersen J,Gauthier F,Jenne DE,Marchand-Adam S,Chapple IL,Kettritz R,Korkmaz B
Fri Aug 10 00:00:00 EDT 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
300-07 was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 EDT 2018
Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity.
Cell reports
Balan S,Arnold-Schrauf C,Abbas A,Couespel N,Savoret J,Imperatore F,Villani AC,Vu Manh TP,Bhardwaj N,Dalod M
300-07 was used in Cell Culture to develop a dendritic cell (DC) differentiation method from human CD34+ precursors leading to high yields of plasmacytoid DCs and both types of conventional DCs.
Tue Aug 14 00:00:00 EDT 2018
Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.
Nature communications
Laustsen A,Bak RO,Krapp C,Kjær L,Egedahl JH,Petersen CC,Pillai S,Tang HQ,Uldbjerg N,Porteus M,Roan NR,Nyegaard M,Denton PW,Jakobsen MR
Thu Aug 30 00:00:00 EDT 2018
Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons.
Scientific reports
DeRosa BA,El Hokayem J,Artimovich E,Garcia-Serje C,Phillips AW,Van Booven D,Nestor JE,Wang L,Cuccaro ML,Vance JM,Pericak-Vance MA,Cukier HN,Nestor MW,Dykxhoorn DM
Wed May 30 00:00:00 EDT 2018
Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes.
Nature communications
Stevens BM,Khan N,D'Alessandro A,Nemkov T,Winters A,Jones CL,Zhang W,Pollyea DA,Jordan CT
Wed Sep 12 00:00:00 EDT 2018
Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors.
Scientific reports
Eicke D,Baigger A,Schulze K,Latham SL,Halloin C,Zweigerdt R,Guzman CA,Blasczyk R,Figueiredo C
Thu Jul 05 00:00:00 EDT 2018
Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro.
Stem cell reports
Garcia-Alegria E,Menegatti S,Fadlullah MZH,Menendez P,Lacaud G,Kouskoff V
Tue Nov 13 00:00:00 EST 2018
Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23.
Nature communications
Xu Y,Sun Y,Shen H,Dai Y,Liu H,Li R,Zhang H,Wu L,Zhu X,Liu X
Mon Sep 24 00:00:00 EDT 2018
Pathological modelling of pigmentation disorders associated with Hutchinson-Gilford Progeria Syndrome (HGPS) revealed an impaired melanogenesis pathway in iPS-derived melanocytes.
Scientific reports
Lo Cicero A,Saidani M,Allouche J,Egesipe AL,Hoch L,Bruge C,Sigaudy S,De Sandre-Giovannoli A,Levy N,Baldeschi C,Nissan X
Thu Jun 14 00:00:00 EDT 2018
Reconstruction of complex single-cell trajectories using CellRouter.
Nature communications
Lummertz da Rocha E,Rowe RG,Lundin V,Malleshaiah M,Jha DK,Rambo CR,Li H,North TE,Collins JJ,Daley GQ
Thu Mar 01 00:00:00 EST 2018
Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation.
Scientific reports
Biechonski S,Olender L,Zipin-Roitman A,Yassin M,Aqaqe N,Marcu-Malina V,Rall-Scharpf M,Trottier M,Meyn MS,Wiesmüller L,Beider K,Raz Y,Grisaru D,Nagler A,Milyavsky M
Tue Apr 17 00:00:00 EDT 2018
Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells.
Stem cell reports
Tusa I,Cheloni G,Poteti M,Gozzini A,DeSouza NH,Shan Y,Deng X,Gray NS,Li S,Rovida E,Dello Sbarba P
Tue Oct 09 00:00:00 EDT 2018
iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.
Cell death & disease
Melguizo-Sanchis D,Xu Y,Taheem D,Yu M,Tilgner K,Barta T,Gassner K,Anyfantis G,Wan T,Elango R,Alharthi S,El-Harouni AA,Przyborski S,Adam S,Saretzki G,Samarasinghe S,Armstrong L,Lako M
Fri Jan 26 00:00:00 EST 2018
Leukaemic alterations of IKZF1 prime stemness and malignancy programs in human lymphocytes.
Cell death & disease
Li Z,Li SP,Li RY,Zhu H,Liu X,Guo XL,Mu LL,Cai JJ,Bai F,Chen GQ,Hong DL
Tue May 01 00:00:00 EDT 2018
Maintenance of human haematopoietic stem and progenitor cells in vitro using a chemical cocktail.
Cell discovery
Jiang M,Chen H,Lai S,Wang R,Qiu Y,Ye F,Fei L,Sun H,Xu Y,Jiang X,Zhou Z,Zhang T,Li Y,Xie J,Fang Q,Gale RP,Han X,Huang H,Guo G
Thu Oct 01 00:00:00 EDT 2020
c-Abl-TWIST1 Epigenetically Dysregulate Inflammatory Responses during Mycobacterial Infection by Co-Regulating Bone Morphogenesis Protein and miR27a.
Frontiers in immunology
Mahadik K,Prakhar P,Rajmani RS,Singh A,Balaji KN
300-07 was used in In vitro experiments to suggest molecular mechanisms of host pathways hijacked by mycobacteria and expand our understanding of c-Abl inhibitors in potentiating innate immune responses.
Thu Feb 28 00:00:00 EST 2019
Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia.
Nature communications
Shiozawa Y,Malcovati L,Gallì A,Sato-Otsubo A,Kataoka K,Sato Y,Watatani Y,Suzuki H,Yoshizato T,Yoshida K,Sanada M,Makishima H,Shiraishi Y,Chiba K,Hellström-Lindberg E,Miyano S,Ogawa S,Cazzola M
Fri Sep 07 00:00:00 EDT 2018
Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.
Stem cell reports
Brownjohn PW,Smith J,Solanki R,Lohmann E,Houlden H,Hardy J,Dietmann S,Livesey FJ
Tue Apr 10 00:00:00 EDT 2018
MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
Nature communications
Skucha A,Ebner J,Schmöllerl J,Roth M,Eder T,César-Razquin A,Stukalov A,Vittori S,Muhar M,Lu B,Aichinger M,Jude J,Müller AC,Győrffy B,Vakoc CR,Valent P,Bennett KL,Zuber J,Superti-Furga G,Grebien F
Fri May 18 00:00:00 EDT 2018
Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal.
Cell death & disease
Toofan P,Busch C,Morrison H,O'Brien S,Jørgensen H,Copland M,Wheadon H
Tue Sep 11 00:00:00 EDT 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
Tue Oct 09 00:00:00 EDT 2018
Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.
Nature communications
Balcerek J,Jiang J,Li Y,Jiang Q,Holdreith N,Singh B,Chandra V,Lv K,Ren JG,Rozenova K,Li W,Greenberg RA,Tong W
Tue Sep 25 00:00:00 EDT 2018
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.
Nature
Raffel S,Falcone M,Kneisel N,Hansson J,Wang W,Lutz C,Bullinger L,Poschet G,Nonnenmacher Y,Barnert A,Bahr C,Zeisberger P,Przybylla A,Sohn M,Tönjes M,Erez A,Adler L,Jensen P,Scholl C,Fröhling S,Cocciardi S,Wuchter P,Thiede C,Flörcken A,Westermann J,Ehninger G,Lichter P,Hiller K,Hell R,Herrmann C,Ho AD,Krijgsveld J,Radlwimmer B,Trumpp A
Thu Nov 16 00:00:00 EST 2017
Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.
Cell
Kim AR,Ulirsch JC,Wilmes S,Unal E,Moraga I,Karakukcu M,Yuan D,Kazerounian S,Abdulhay NJ,King DS,Gupta N,Gabriel SB,Lander ES,Patiroglu T,Ozcan A,Ozdemir MA,Garcia KC,Piehler J,Gazda HT,Klein DE,Sankaran VG
300-07 was used in In vitro experiments to demonstrate how variation in a single cytokine can lead to biased downstream signaling and can thereby cause human disease.
Thu Mar 09 00:00:00 EST 2017
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.
Cell
Cimmino L,Dolgalev I,Wang Y,Yoshimi A,Martin GH,Wang J,Ng V,Xia B,Witkowski MT,Mitchell-Flack M,Grillo I,Bakogianni S,Ndiaye-Lobry D,Martín MT,Guillamot M,Banh RS,Xu M,Figueroa ME,Dickins RA,Abdel-Wahab O,Park CY,Tsirigos A,Neel BG,Aifantis I
300-07 was used in In vitro experiments to determine the role of TET2 deficiency in leukaemia stem cell maintenance.
Thu Sep 07 00:00:00 EDT 2017
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Cell
Spencer DH,Russler-Germain DA,Ketkar S,Helton NM,Lamprecht TL,Fulton RS,Fronick CC,O'Laughlin M,Heath SE,Shinawi M,Westervelt P,Payton JE,Wartman LD,Welch JS,Wilson RK,Walter MJ,Link DC,DiPersio JF,Ley TJ
Thu Feb 23 00:00:00 EST 2017
MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
Cancer cell
Chen Y,Anastassiadis K,Kranz A,Stewart AF,Arndt K,Waskow C,Yokoyama A,Jones K,Neff T,Lee Y,Ernst P
Mon Jun 12 00:00:00 EDT 2017
CCL2 is a KIT D816V-dependent modulator of the bone marrow microenvironment in systemic mastocytosis.
Blood
Greiner G,Witzeneder N,Berger A,Schmetterer K,Eisenwort G,Schiefer AI,Roos S,Popow-Kraupp T,Müllauer L,Zuber J,Sexl V,Kenner L,Sperr WR,Valent P,Mayerhofer M,Hoermann G
Thu Jan 19 00:00:00 EST 2017
Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia.
Blood
Serafin V,Capuzzo G,Milani G,Minuzzo SA,Pinazza M,Bortolozzi R,Bresolin S,Porcù E,Frasson C,Indraccolo S,Basso G,Accordi B
Thu Dec 21 00:00:00 EST 2017
Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.
Autophagy
Chen X,Clark J,Wunderlich M,Fan C,Davis A,Chen S,Guan JL,Mulloy JC,Kumar A,Zheng Y
300-07 was used in Cell Culture to uncover anti-leukemic effects of choloroquine being independent of autophagy which can be enhanced via vesicular exocytotis inhibition, and autophagy being an insignificant target of MA9-AML therapy.
Thu May 04 00:00:00 EDT 2017
Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Gao X,Lee HY,Li W,Platt RJ,Barrasa MI,Ma Q,Elmes RR,Rosenfeld MG,Lodish HF
Tue Sep 19 00:00:00 EDT 2017
Macrophages confer survival signals via CCR1-dependent translational MCL-1 induction in chronic lymphocytic leukemia.
Oncogene
van Attekum MHA,Terpstra S,Slinger E,von Lindern M,Moerland PD,Jongejan A,Kater AP,Eldering E
Thu Jun 29 00:00:00 EDT 2017
Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.
Stem cells translational medicine
Gori JL,Butler JM,Kunar B,Poulos MG,Ginsberg M,Nolan DJ,Norgaard ZK,Adair JE,Rafii S,Kiem HP
Wed Mar 01 00:00:00 EST 2017
Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.
Stem cells translational medicine
Gori JL,Butler JM,Kunar B,Poulos MG,Ginsberg M,Nolan DJ,Norgaard ZK,Adair JE,Rafii S,Kiem HP
Wed Mar 01 00:00:00 EST 2017
Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential.
Frontiers in oncology
Roy A,Libard S,Weishaupt H,Gustavsson I,Uhrbom L,Hesselager G,Swartling FJ,Pontén F,Alafuzoff I,Tchougounova E
300-07 was used in Cell Culture to indicate MCs' capability of modulating gene expression in BM cells and suggest that MCs can serve as a new target for drug development against metastases in the brain.
Sun Jan 03 00:00:00 EST 2021
CXCL12-CXCR4 Axis Is Required for Contact-Mediated Human B Lymphoid and Plasmacytoid Dendritic Cell Differentiation but Not T Lymphoid Generation.
Journal of immunology (Baltimore, Md. : 1950)
Minami H,Nagaharu K,Nakamori Y,Ohishi K,Shimojo N,Kageyama Y,Matsumoto T,Sugimoto Y,Tawara I,Masuya M,Miwa H,Katayama N
Sun Oct 01 00:00:00 EDT 2017
Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Akoto C,Davies DE,Swindle EJ
Wed Mar 01 00:00:00 EST 2017
Arachidonic acid and Docosahexanoic acid enhance platelet formation from human apheresis-derived CD34+ cells.
Cell cycle (Georgetown, Tex.)
Dhenge A,Limbkar K,Melinkeri S,Kale VP,Limaye L
300-07 was used in Cell Culture to examine the role of poly-unsaturated fatty acids in platelet production.
Fri May 19 00:00:00 EDT 2017
A potential bioactive hard-stock fat replacer comprised of a molecular gel.
Food science & nutrition
Rogers MA,Spagnuolo PA,Wang TM,Angka L
Mon May 01 00:00:00 EDT 2017
Evidence of In Vitro Preservation of Human Nephrogenesis at the Single-Cell Level.
Stem cell reports
Pode-Shakked N,Gershon R,Tam G,Omer D,Gnatek Y,Kanter I,Oriel S,Katz G,Harari-Steinberg O,Kalisky T,Dekel B
Tue Jul 11 00:00:00 EDT 2017
KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression.
Nature communications
Zhao H,Wang X,Yi P,Si Y,Tan P,He J,Yu S,Ren Y,Ma Y,Zhang J,Wang D,Wang F,Yu J
Fri Nov 10 00:00:00 EST 2017
The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age.
Nature communications
Hosokawa K,MacArthur BD,Ikushima YM,Toyama H,Masuhiro Y,Hanazawa S,Suda T,Arai F
Fri Oct 06 00:00:00 EDT 2017
Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities.
Oncoimmunology
Van Caeneghem Y,De Munter S,Tieppo P,Goetgeluk G,Weening K,Verstichel G,Bonte S,Taghon T,Leclercq G,Kerre T,Debets R,Vermijlen D,Abken H,Vandekerckhove B
300-07 was used in Flow cytometry/Cell sorting to show that cord blood hematopoietic progenitor cells generate allogeneic CD3-antigen receptor (AR)+T cells which effectively eliminate malignant cells and limit graft versus host disease occurrence.
Tue Jan 12 00:00:00 EST 2021
Apoptotic resistance of human skin mast cells is mediated by Mcl-1.
Cell death discovery
Hazzan T,Eberle J,Worm M,Babina M
Tue Sep 29 00:00:00 EDT 2020
Downregulation of PARP1 transcription by promoter-associated E2F4-RBL2-HDAC1-BRM complex contributes to repression of pluripotency stem cell factors in human monocytes.
Scientific reports
Wiśnik E,Płoszaj T,Robaszkiewicz A
Fri Aug 25 00:00:00 EDT 2017
Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation.
Stem cell reports
Di Tullio A,Passaro D,Rouault-Pierre K,Purewal S,Bonnet D
Tue Jul 11 00:00:00 EDT 2017
Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.
Stem cell reports
Li Y,Brauer PM,Singh J,Xhiku S,Yoganathan K,Zúñiga-Pflücker JC,Anderson MK
Tue Sep 12 00:00:00 EDT 2017
CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells.
Cancer medicine
Ueshima C,Kataoka TR,Takei Y,Hirata M,Sugimoto A,Hirokawa M,Okayama Y,Blumberg RS,Haga H
Sat Apr 01 00:00:00 EDT 2017
High-throughput assessment of mechanical properties of stem cell derived red blood cells, toward cellular downstream processing.
Scientific reports
Guzniczak E,Mohammad Zadeh M,Dempsey F,Jimenez M,Bock H,Whyte G,Willoughby N,Bridle H
Tue Oct 31 00:00:00 EDT 2017
Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells.
Stem cell reports
Zeng J,Tang SY,Toh LL,Wang S
Tue Dec 12 00:00:00 EST 2017
Enforced GFI1 expression impedes human and murine leukemic cell growth.
Scientific reports
Hönes JM,Thivakaran A,Botezatu L,Patnana P,Castro SVDC,Al-Matary YS,Schütte J,Fischer KBI,Vassen L,Görgens A,Dührsen U,Giebel B,Khandanpour C
Thu Nov 16 00:00:00 EST 2017
Material Viscoelastic Properties Modulate the Mesenchymal Stem Cell Secretome for Applications in Hematopoietic Recovery.
ACS biomaterials science & engineering
Liu FD,Pishesha N,Poon Z,Kaushik T,Van Vliet KJ
300-07 was used in Cell Culture to leverage cell-material interactions in vitro to induce human bone marrow-derived MSCs to preferentially secrete factors that are beneficial to hematopoietic cell proliferation.
Mon Dec 11 00:00:00 EST 2017
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.
Nature biotechnology
Stevens MM,Maire CL,Chou N,Murakami MA,Knoff DS,Kikuchi Y,Kimmerling RJ,Liu H,Haidar S,Calistri NL,Cermak N,Olcum S,Cordero NA,Idbaih A,Wen PY,Weinstock DM,Ligon KL,Manalis SR
300-07 was used in In vitro experiments to investigate assays for tumour cell therapeutic response.
Tue Nov 01 00:00:00 EDT 2016
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.
Cell
Puram RV,Kowalczyk MS,de Boer CG,Schneider RK,Miller PG,McConkey M,Tothova Z,Tejero H,Heckl D,Järås M,Chen MC,Li H,Tamayo A,Cowley GS,Rozenblatt-Rosen O,Al-Shahrour F,Regev A,Ebert BL
Thu Apr 07 00:00:00 EDT 2016
JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis.
Blood
Grisouard J,Li S,Kubovcakova L,Rao TN,Meyer SC,Lundberg P,Hao-Shen H,Romanet V,Murakami M,Radimerski T,Dirnhofer S,Skoda RC
Thu Aug 11 00:00:00 EDT 2016
JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis.
Blood
Grisouard J,Li S,Kubovcakova L,Rao TN,Meyer SC,Lundberg P,Hao-Shen H,Romanet V,Murakami M,Radimerski T,Dirnhofer S,Skoda RC
Thu Aug 11 00:00:00 EDT 2016
UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.
Blood
Samudio I,Rezvani K,Shaim H,Hofs E,Ngom M,Bu L,Liu G,Lee JT,Imren S,Lam V,Poon GF,Ghaedi M,Takei F,Humphries K,Jia W,Krystal G
Thu May 26 00:00:00 EDT 2016
Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.
Blood
Dahlin JS,Malinovschi A,Öhrvik H,Sandelin M,Janson C,Alving K,Hallgren J
Thu Jan 28 00:00:00 EST 2016
Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells.
Blood
Dhahri D,Sato-Kusubata K,Ohki-Koizumi M,Nishida C,Tashiro Y,Munakata S,Shimazu H,Salama Y,Eiamboonsert S,Nakauchi H,Hattori K,Heissig B
Thu Aug 25 00:00:00 EDT 2016
Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion.
Blood
Chesnais V,Renneville A,Toma A,Lambert J,Passet M,Dumont F,Chevret S,Lejeune J,Raimbault A,Stamatoullas A,Rose C,Beyne-Rauzy O,Delaunay J,Solary E,Fenaux P,Dreyfus F,Preudhomme C,Kosmider O,Fontenay M
Thu Feb 11 00:00:00 EST 2016
Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.
The Journal of clinical investigation
Brendel C,Guda S,Renella R,Bauer DE,Canver MC,Kim YJ,Heeney MM,Klatt D,Fogel J,Milsom MD,Orkin SH,Gregory RI,Williams DA
Mon Oct 03 00:00:00 EDT 2016
Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.
The Journal of clinical investigation
Gu H,Chen C,Hao X,Wang C,Zhang X,Li Z,Shao H,Zeng H,Yu Z,Xie L,Xia F,Zhang F,Liu X,Zhang Y,Jiang H,Zhu J,Wan J,Wang C,Weng W,Xie J,Tao M,Zhang CC,Liu J,Chen GQ,Zheng J
Thu Dec 01 00:00:00 EST 2016
Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia.
The Journal of clinical investigation
Jin Y,Zhou J,Xu F,Jin B,Cui L,Wang Y,Du X,Li J,Li P,Ren R,Pan J
Mon Oct 03 00:00:00 EDT 2016
Targeting MTHFD2 in acute myeloid leukemia.
The Journal of experimental medicine
Pikman Y,Puissant A,Alexe G,Furman A,Chen LM,Frumm SM,Ross L,Fenouille N,Bassil CF,Lewis CA,Ramos A,Gould J,Stone RM,DeAngelo DJ,Galinsky I,Clish CB,Kung AL,Hemann MT,Vander Heiden MG,Banerji V,Stegmaier K
Mon Jun 27 00:00:00 EDT 2016
Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.
The Journal of experimental medicine
Cheung KL,Jarrett R,Subramaniam S,Salimi M,Gutowska-Owsiak D,Chen YL,Hardman C,Xue L,Cerundolo V,Ogg G
Mon Oct 17 00:00:00 EDT 2016
Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease.
The Journal of experimental medicine
Azad P,Zhao HW,Cabrales PJ,Ronen R,Zhou D,Poulsen O,Appenzeller O,Hsiao YH,Bafna V,Haddad GG
Mon Nov 14 00:00:00 EST 2016
ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America
Gregory MA,D'Alessandro A,Alvarez-Calderon F,Kim J,Nemkov T,Adane B,Rozhok AI,Kumar A,Kumar V,Pollyea DA,Wempe MF,Jordan CT,Serkova NJ,Tan AC,Hansen KC,DeGregori J
Tue Oct 25 00:00:00 EDT 2016
Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos.
Proceedings of the National Academy of Sciences of the United States of America
Cohen MA,Wert KJ,Goldmann J,Markoulaki S,Buganim Y,Fu D,Jaenisch R
Tue Feb 09 00:00:00 EST 2016
Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis.
Stem cells (Dayton, Ohio)
Sweeney CL,Teng R,Wang H,Merling RK,Lee J,Choi U,Koontz S,Wright DG,Malech HL
Wed Jun 01 00:00:00 EDT 2016
Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis.
Stem cells (Dayton, Ohio)
Sweeney CL,Teng R,Wang H,Merling RK,Lee J,Choi U,Koontz S,Wright DG,Malech HL
Wed Jun 01 00:00:00 EDT 2016
Letter to the Editor: Production of Mature Healthy Hematopoietic Cells from Induced Pluripotent Stem Cells Derived from an AML Diagnostic Sample Containing the t(8;21) Translocation.
Stem cells (Dayton, Ohio)
Hoffmann D,Göhring G,Heuser M,Ganser A,Schambach A,Morgan MA
Tue Mar 01 00:00:00 EST 2016
Expansion of Th17 Cells by Human Mast Cells Is Driven by Inflammasome-Independent IL-1β.
Journal of immunology (Baltimore, Md. : 1950)
Suurmond J,Habets KL,Dorjée AL,Huizinga TW,Toes RE
Thu Dec 01 00:00:00 EST 2016
CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI.
Cell cycle (Georgetown, Tex.)
Moreno-Lorenzana D,Avilés-Vazquez S,Sandoval Esquivel MA,Alvarado-Moreno A,Ortiz-Navarrete V,Torres-Martínez H,Ayala-Sánchez M,Mayani H,Chavez-Gonzalez A
300-07 was used in Sample Preparation (FC/FACS) to analyze the cell cycle status, levels of several CDKIs and the subcellular localization of such molecules in different Chronic Myeloid Leukemia (CML) cell lines, as well as primary CD34(+)CD38(-)lin(-) LSC and HSC to understand the role of Cyclin Dependent Kinase Inhibitors in CML LSC permanence after tyrosine kinase inhibitor (TKI) treatment.
Mon May 02 00:00:00 EDT 2016
Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors.
Stem cell reports
Wen W,Zhang JP,Xu J,Su RJ,Neises A,Ji GZ,Yuan W,Cheng T,Zhang XB
Tue Jun 14 00:00:00 EDT 2016
GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.
Stem cell reports
D'Souza SS,Maufort J,Kumar A,Zhang J,Smuga-Otto K,Thomson JA,Slukvin II
Tue Feb 09 00:00:00 EST 2016
Ikaros Is a Negative Regulator of B1 Cell Development and Function.
The Journal of biological chemistry
Macias-Garcia A,Heizmann B,Sellars M,Marchal P,Dali H,Pasquali JL,Muller S,Kastner P,Chan S
Fri Apr 22 00:00:00 EDT 2016
Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency.
Scientific reports
Ikeda K,Ueda T,Yamasaki N,Nakata Y,Sera Y,Nagamachi A,Miyama T,Kobayashi H,Takubo K,Kanai A,Oda H,Wolff L,Honda Z,Ichinohe T,Matsubara A,Suda T,Inaba T,Honda H
Tue Jul 19 00:00:00 EDT 2016
Dual-SMAD Inhibition/WNT Activation-Based Methods to Induce Neural Crest and Derivatives from Human Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.)
Chambers SM,Mica Y,Lee G,Studer L,Tomishima MJ
300-07 was used in In vitro experiments to provide methods to direct NC into two different terminal fates: melanocytes and sensory neurons.
Mon May 16 00:00:00 EDT 2016
BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors.
Cell death & disease
Korfi K,Smith M,Swan J,Somervaille TC,Dhomen N,Marais R
Thu Apr 07 00:00:00 EDT 2016
Acetylation of C/EBPα inhibits its granulopoietic function.
Nature communications
Bararia D,Kwok HS,Welner RS,Numata A,Sárosi MB,Yang H,Wee S,Tschuri S,Ray D,Weigert O,Levantini E,Ebralidze AK,Gunaratne J,Tenen DG
Wed Mar 23 00:00:00 EDT 2016
Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation.
Stem cell reports
Saxena S,Rönn RE,Guibentif C,Moraghebi R,Woods NB
Tue May 10 00:00:00 EDT 2016
Human somatic cells subjected to genetic induction with six germ line-related factors display meiotic germ cell-like features.
Scientific reports
Medrano JV,Martínez-Arroyo AM,Míguez JM,Moreno I,Martínez S,Quiñonero A,Díaz-Gimeno P,Marqués-Marí AI,Pellicer A,Remohí J,Simón C
Tue Apr 26 00:00:00 EDT 2016
The Combination of CRISPR/Cas9 and iPSC Technologies in the Gene Therapy of Human β-thalassemia in Mice.
Scientific reports
Ou Z,Niu X,He W,Chen Y,Song B,Xian Y,Fan D,Tang D,Sun X
Thu Sep 01 00:00:00 EDT 2016
Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.
Nature communications
Adair JE,Waters T,Haworth KG,Kubek SP,Trobridge GD,Hocum JD,Heimfeld S,Kiem HP
Thu Oct 20 00:00:00 EDT 2016
Induction of Germ Cell-like Cells from Porcine Induced Pluripotent Stem Cells.
Scientific reports
Wang H,Xiang J,Zhang W,Li J,Wei Q,Zhong L,Ouyang H,Han J
Mon Jun 06 00:00:00 EDT 2016
Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.
Scientific reports
Chen JJ,Gao XT,Yang L,Fu W,Liang L,Li JC,Hu B,Sun ZJ,Huang SY,Zhang YZ,Liang YM,Qin HY,Han H
Wed May 18 00:00:00 EDT 2016
Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.
Scientific reports
Chen JJ,Gao XT,Yang L,Fu W,Liang L,Li JC,Hu B,Sun ZJ,Huang SY,Zhang YZ,Liang YM,Qin HY,Han H
Wed May 18 00:00:00 EDT 2016
ASXL1 plays an important role in erythropoiesis.
Scientific reports
Shi H,Yamamoto S,Sheng M,Bai J,Zhang P,Chen R,Chen S,Shi L,Abdel-Wahab O,Xu M,Zhou Y,Yang FC
Wed Jun 29 00:00:00 EDT 2016
Dissecting Stages of Human Kidney Development and Tumorigenesis with Surface Markers Affords Simple Prospective Purification of Nephron Stem Cells.
Scientific reports
Pode-Shakked N,Pleniceanu O,Gershon R,Shukrun R,Kanter I,Bucris E,Pode-Shakked B,Tam G,Tam H,Caspi R,Pri-Chen S,Vax E,Katz G,Omer D,Harari-Steinberg O,Kalisky T,Dekel B
Tue Mar 29 00:00:00 EDT 2016
Chromothriptic cure of WHIM syndrome.
Cell
McDermott DH,Gao JL,Liu Q,Siwicki M,Martens C,Jacobs P,Velez D,Yim E,Bryke CR,Hsu N,Dai Z,Marquesen MM,Stregevsky E,Kwatemaa N,Theobald N,Long Priel DA,Pittaluga S,Raffeld MA,Calvo KR,Maric I,Desmond R,Holmes KL,Kuhns DB,Balabanian K,Bachelerie F,Porcella SF,Malech HL,Murphy PM
Thu Feb 12 00:00:00 EST 2015
Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.
Cancer cell
Borkin D,He S,Miao H,Kempinska K,Pollock J,Chase J,Purohit T,Malik B,Zhao T,Wang J,Wen B,Zong H,Jones M,Danet-Desnoyers G,Guzman ML,Talpaz M,Bixby DL,Sun D,Hess JL,Muntean AG,Maillard I,Cierpicki T,Grembecka J
Mon Apr 13 00:00:00 EDT 2015
Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.
Blood
Kinkel SA,Galeev R,Flensburg C,Keniry A,Breslin K,Gilan O,Lee S,Liu J,Chen K,Gearing LJ,Moore DL,Alexander WS,Dawson M,Majewski IJ,Oshlack A,Larsson J,Blewitt ME
Thu Mar 19 00:00:00 EDT 2015
Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.
Blood
Maude SL,Dolai S,Delgado-Martin C,Vincent T,Robbins A,Selvanathan A,Ryan T,Hall J,Wood AC,Tasian SK,Hunger SP,Loh ML,Mullighan CG,Wood BL,Hermiston ML,Grupp SA,Lock RB,Teachey DT
Thu Mar 12 00:00:00 EDT 2015
Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells.
Blood
Hoban MD,Cost GJ,Mendel MC,Romero Z,Kaufman ML,Joglekar AV,Ho M,Lumaquin D,Gray D,Lill GR,Cooper AR,Urbinati F,Senadheera S,Zhu A,Liu PQ,Paschon DE,Zhang L,Rebar EJ,Wilber A,Wang X,Gregory PD,Holmes MC,Reik A,Hollis RP,Kohn DB
Thu Apr 23 00:00:00 EDT 2015
Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.
Blood
Jang IH,Lu YF,Zhao L,Wenzel PL,Kume T,Datta SM,Arora N,Guiu J,Lagha M,Kim PG,Do EK,Kim JH,Schlaeger TM,Zon LI,Bigas A,Burns CE,Daley GQ
Thu Feb 26 00:00:00 EST 2015
A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor.
Blood
Belay E,Miller CP,Kortum AN,Torok-Storb B,Blau CA,Emery DW
Thu Feb 05 00:00:00 EST 2015
Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.
Blood
Sinha S,Thomas D,Yu L,Gentles AJ,Jung N,Corces-Zimmerman MR,Chan SM,Reinisch A,Feinberg AP,Dill DL,Majeti R
Thu Jan 08 00:00:00 EST 2015
MLL leukemia induction by genome editing of human CD34+ hematopoietic cells.
Blood
Buechele C,Breese EH,Schneidawind D,Lin CH,Jeong J,Duque-Afonso J,Wong SH,Smith KS,Negrin RS,Porteus M,Cleary ML
Thu Oct 01 00:00:00 EDT 2015
Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis.
Blood
Schwartz C,Willebrand R,Huber S,Rupec RA,Wu D,Locksley R,Voehringer D
Thu Jun 18 00:00:00 EDT 2015
Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia.
The Journal of clinical investigation
Meldi K,Qin T,Buchi F,Droin N,Sotzen J,Micol JB,Selimoglu-Buet D,Masala E,Allione B,Gioia D,Poloni A,Lunghi M,Solary E,Abdel-Wahab O,Santini V,Figueroa ME
Fri May 01 00:00:00 EDT 2015
Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.
The Journal of clinical investigation
Nayak RC,Trump LR,Aronow BJ,Myers K,Mehta P,Kalfa T,Wellendorf AM,Valencia CA,Paddison PJ,Horwitz MS,Grimes HL,Lutzko C,Cancelas JA
Mon Aug 03 00:00:00 EDT 2015
A single glycan on IgE is indispensable for initiation of anaphylaxis.
The Journal of experimental medicine
Shade KT,Platzer B,Washburn N,Mani V,Bartsch YC,Conroy M,Pagan JD,Bosques C,Mempel TR,Fiebiger E,Anthony RM
Mon Apr 06 00:00:00 EDT 2015
Circulating precursors of human CD1c+ and CD141+ dendritic cells.
The Journal of experimental medicine
Breton G,Lee J,Zhou YJ,Schreiber JJ,Keler T,Puhr S,Anandasabapathy N,Schlesinger S,Caskey M,Liu K,Nussenzweig MC
Mon Mar 09 00:00:00 EDT 2015
CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo.
The Journal of experimental medicine
Mende N,Kuchen EE,Lesche M,Grinenko T,Kokkaliaris KD,Hanenberg H,Lindemann D,Dahl A,Platz A,Höfer T,Calegari F,Waskow C
Mon Jul 27 00:00:00 EDT 2015
Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow.
The Journal of experimental medicine
Lee J,Breton G,Oliveira TY,Zhou YJ,Aljoufi A,Puhr S,Cameron MJ,Sékaly RP,Nussenzweig MC,Liu K
Mon Mar 09 00:00:00 EDT 2015
Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.
Proceedings of the National Academy of Sciences of the United States of America
Yin J,Leavenworth JW,Li Y,Luo Q,Xie H,Liu X,Huang S,Yan H,Fu Z,Zhang LY,Zhang L,Hao J,Wu X,Deng X,Roberts CW,Orkin SH,Cantor H,Wang X
Tue Dec 29 00:00:00 EST 2015
Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.
British journal of haematology
Sjögren SE,Siva K,Soneji S,George AJ,Winkler M,Jaako P,Wlodarski M,Karlsson S,Hannan RD,Flygare J
Sun Nov 01 00:00:00 EDT 2015
The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.
Stem cells (Dayton, Ohio)
Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS
Wed Apr 01 00:00:00 EDT 2015
The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.
Stem cells (Dayton, Ohio)
Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS
Wed Apr 01 00:00:00 EDT 2015
Molecular signature of erythroblast enucleation in human embryonic stem cells.
Stem cells (Dayton, Ohio)
Rouzbeh S,Kobari L,Cambot M,Mazurier C,Hebert N,Faussat AM,Durand C,Douay L,Lapillonne H
Sat Aug 01 00:00:00 EDT 2015
The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production.
Journal of immunology (Baltimore, Md. : 1950)
Pundir P,MacDonald CA,Kulka M
Tue Sep 15 00:00:00 EDT 2015
Induction of the proapoptotic tumor suppressor gene Cell Adhesion Molecule 1 by chemotherapeutic agents is repressed in therapy resistant acute myeloid leukemia.
Molecular carcinogenesis
Fisser MC,Rommer A,Steinleitner K,Heller G,Herbst F,Wiese M,Glimm H,Sill H,Wieser R
Tue Dec 01 00:00:00 EST 2015
PRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic stem and progenitor cells.
Scientific reports
Varagnolo L,Lin Q,Obier N,Plass C,Dietl J,Zenke M,Claus R,Müller AM
Wed Jul 22 00:00:00 EDT 2015
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Stem cell reports
Garate Z,Quintana-Bustamante O,Crane AM,Olivier E,Poirot L,Galetto R,Kosinski P,Hill C,Kung C,Agirre X,Orman I,Cerrato L,Alberquilla O,Rodriguez-Fornes F,Fusaki N,Garcia-Sanchez F,Maia TM,Ribeiro ML,Sevilla J,Prosper F,Jin S,Mountford J,Guenechea G,Gouble A,Bueren JA,Davis BR,Segovia JC
Tue Dec 08 00:00:00 EST 2015
Opportunistic pathogen Candida albicans elicits a temporal response in primary human mast cells.
Scientific reports
Lopes JP,Stylianou M,Nilsson G,Urban CF
Mon Jul 20 00:00:00 EDT 2015
Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy.
Molecular therapy. Methods & clinical development
Wielgosz MM,Kim YS,Carney GG,Zhan J,Reddivari M,Coop T,Heath RJ,Brown SA,Nienhuis AW
300-07 was used in In vitro experiments to show that the producer cell line and the specific monoclonal antibody will facilitate the development of a clinical protocol for gene transfer into WAS protein deficient stem cells.
Mon Jun 08 00:00:00 EDT 2015
Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.
Scientific reports
Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J
Mon Oct 12 00:00:00 EDT 2015
Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.
Scientific reports
Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J
Mon Oct 12 00:00:00 EDT 2015
Fancd2 is required for nuclear retention of Foxo3a in hematopoietic stem cell maintenance.
The Journal of biological chemistry
Li X,Li J,Wilson A,Sipple J,Schick J,Pang Q
Fri Jan 30 00:00:00 EST 2015
Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles.
Molecular therapy. Methods & clinical development
Prel A,Caval V,Gayon R,Ravassard P,Duthoit C,Payen E,Maouche-Chretien L,Creneguy A,Nguyen TH,Martin N,Piver E,Sevrain R,Lamouroux L,Leboulch P,Deschaseaux F,Bouillé P,Sensébé L,Pagès JC
Tue Nov 03 00:00:00 EST 2015
Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation.
Nature communications
Cohen ES,Scott IC,Majithiya JB,Rapley L,Kemp BP,England E,Rees DG,Overed-Sayer CL,Woods J,Bond NJ,Veyssier CS,Embrey KJ,Sims DA,Snaith MR,Vousden KA,Strain MD,Chan DT,Carmen S,Huntington CE,Flavell L,Xu J,Popovic B,Brightling CE,Vaughan TJ,Butler R,Lowe DC,Higazi DR,Corkill DJ,May RD,Sleeman MA,Mustelin T
Mon Sep 14 00:00:00 EDT 2015
Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.
Scientific reports
Xie XQ,Yang P,Zhang Y,Zhang P,Wang L,Ding Y,Yang M,Tong Q,Cheng H,Ji Q,McGuire T,Yuan W,Cheng T,Gao Y
Fri Dec 18 00:00:00 EST 2015
AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages.
Cell death & disease
Six E,Lagresle-Peyrou C,Susini S,De Chappedelaine C,Sigrist N,Sadek H,Chouteau M,Cagnard N,Fontenay M,Hermine O,Chomienne C,Reynier P,Fischer A,André-Schmutz I,Gueguen N,Cavazzana M
Thu Aug 13 00:00:00 EDT 2015
Rh D blood group conversion using transcription activator-like effector nucleases.
Nature communications
Kim YH,Kim HO,Baek EJ,Kurita R,Cha HJ,Nakamura Y,Kim H
Tue Jun 16 00:00:00 EDT 2015
Targeted genome editing in human repopulating haematopoietic stem cells.
Nature
Genovese P,Schiroli G,Escobar G,Tomaso TD,Firrito C,Calabria A,Moi D,Mazzieri R,Bonini C,Holmes MC,Gregory PD,van der Burg M,Gentner B,Montini E,Lombardo A,Naldini L
Thu Jun 12 00:00:00 EDT 2014
Chemically defined generation of human cardiomyocytes.
Nature methods
Burridge PW,Matsa E,Shukla P,Lin ZC,Churko JM,Ebert AD,Lan F,Diecke S,Huber B,Mordwinkin NM,Plews JR,Abilez OJ,Cui B,Gold JD,Wu JC
Fri Aug 01 00:00:00 EDT 2014
Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.
Blood
Bots M,Verbrugge I,Martin BP,Salmon JM,Ghisi M,Baker A,Stanley K,Shortt J,Ossenkoppele GJ,Zuber J,Rappaport AR,Atadja P,Lowe SW,Johnstone RW
Thu Feb 27 00:00:00 EST 2014
Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.
Blood
Bots M,Verbrugge I,Martin BP,Salmon JM,Ghisi M,Baker A,Stanley K,Shortt J,Ossenkoppele GJ,Zuber J,Rappaport AR,Atadja P,Lowe SW,Johnstone RW
Thu Feb 27 00:00:00 EST 2014
STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.
Blood
Gough DJ,Marié IJ,Lobry C,Aifantis I,Levy DE
Thu Oct 02 00:00:00 EDT 2014
Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells.
Blood
Nievergall E,Ramshaw HS,Yong AS,Biondo M,Busfield SJ,Vairo G,Lopez AF,Hughes TP,White DL,Hiwase DK
Thu Feb 20 00:00:00 EST 2014
Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells.
Blood
Wang CX,Sather BD,Wang X,Adair J,Khan I,Singh S,Lang S,Adams A,Curinga G,Kiem HP,Miao CH,Rawlings DJ,Torbett BE
Thu Aug 07 00:00:00 EDT 2014
Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes.
Blood
Lee WC,Malleret B,Lau YL,Mauduit M,Fong MY,Cho JS,Suwanarusk R,Zhang R,Albrecht L,Costa FT,Preiser P,McGready R,Renia L,Nosten F,Russell B
Thu May 01 00:00:00 EDT 2014
Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations.
Blood
Traer E,Javidi-Sharifi N,Agarwal A,Dunlap J,English I,Martinez J,Tyner JW,Wong M,Druker BJ
Thu Mar 06 00:00:00 EST 2014
The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells.
Blood
Yang Z,Augustin J,Chang C,Hu J,Shah K,Chang CW,Townes T,Jiang H
Thu Sep 25 00:00:00 EDT 2014
Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.
The Journal of clinical investigation
Velu CS,Chaubey A,Phelan JD,Horman SR,Wunderlich M,Guzman ML,Jegga AG,Zeleznik-Le NJ,Chen J,Mulloy JC,Cancelas JA,Jordan CT,Aronow BJ,Marcucci G,Bhat B,Gebelein B,Grimes HL
Wed Jan 01 00:00:00 EST 2014
RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.
The Journal of experimental medicine
Verma R,Su S,McCrann DJ,Green JM,Leu K,Young PR,Schatz PJ,Silva JC,Stokes MP,Wojchowski DM
Mon Aug 25 00:00:00 EDT 2014
BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.
The Journal of experimental medicine
Berres ML,Lim KP,Peters T,Price J,Takizawa H,Salmon H,Idoyaga J,Ruzo A,Lupo PJ,Hicks MJ,Shih A,Simko SJ,Abhyankar H,Chakraborty R,Leboeuf M,Beltrão M,Lira SA,Heym KM,Bigley V,Collin M,Manz MG,McClain K,Merad M,Allen CE
Mon Apr 07 00:00:00 EDT 2014
Quantitative and stoichiometric analysis of the microRNA content of exosomes.
Proceedings of the National Academy of Sciences of the United States of America
Chevillet JR,Kang Q,Ruf IK,Briggs HA,Vojtech LN,Hughes SM,Cheng HH,Arroyo JD,Meredith EK,Gallichotte EN,Pogosova-Agadjanyan EL,Morrissey C,Stirewalt DL,Hladik F,Yu EY,Higano CS,Tewari M
Tue Oct 14 00:00:00 EDT 2014
IL-33/ST2 axis promotes mast cell survival via BCLXL.
Proceedings of the National Academy of Sciences of the United States of America
Wang JX,Kaieda S,Ameri S,Fishgal N,Dwyer D,Dellinger A,Kepley CL,Gurish MF,Nigrovic PA
Tue Jul 15 00:00:00 EDT 2014
The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia.
Cell death and differentiation
Gong JN,Yu J,Lin HS,Zhang XH,Yin XL,Xiao Z,Wang F,Wang XS,Su R,Shen C,Zhao HL,Ma YN,Zhang JW
Wed Jan 01 00:00:00 EST 2014
Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model.
Molecular therapy. Nucleic acids
Haemmerle R,Phaltane R,Rothe M,Schröder S,Schambach A,Moritz T,Modlich U
Tue Oct 07 00:00:00 EDT 2014
Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells.
Blood cancer journal
Askmyr M,Ågerstam H,Lilljebjörn H,Hansen N,Karlsson C,von Palffy S,Landberg N,Högberg C,Lassen C,Rissler M,Richter J,Ehinger M,Järås M,Fioretos T
Fri Dec 12 00:00:00 EST 2014
Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells.
Journal of lipid research
Dichlberger A,Schlager S,Maaninka K,Schneider WJ,Kovanen PT
Mon Dec 01 00:00:00 EST 2014
EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300.
Stem cells (Dayton, Ohio)
Zheng WW,Dong XM,Yin RH,Xu FF,Ning HM,Zhang MJ,Xu CW,Yang Y,Ding YL,Wang ZD,Zhao WB,Tang LJ,Chen H,Wang XH,Zhan YQ,Yu M,Ge CH,Li CY,Yang XM
Fri Aug 01 00:00:00 EDT 2014
Expression of chimeric receptor CD4ζ by natural killer cells derived from human pluripotent stem cells improves in vitro activity but does not enhance suppression of HIV infection in vivo.
Stem cells (Dayton, Ohio)
Ni Z,Knorr DA,Bendzick L,Allred J,Kaufman DS
Tue Apr 01 00:00:00 EDT 2014
Generation of functional, antigen-specific CD8+ human T cells from cord blood stem cells using exogenous Notch and tetramer-TCR signaling.
Stem cells (Dayton, Ohio)
Fernandez I,Ooi TP,Roy K
Wed Jan 01 00:00:00 EST 2014
Conversion of human fibroblasts into monocyte-like progenitor cells.
Stem cells (Dayton, Ohio)
Pulecio J,Nivet E,Sancho-Martinez I,Vitaloni M,Guenechea G,Xia Y,Kurian L,Dubova I,Bueren J,Laricchia-Robbio L,Belmonte JCI
Sat Nov 01 00:00:00 EDT 2014
Conversion of human fibroblasts into monocyte-like progenitor cells.
Stem cells (Dayton, Ohio)
Pulecio J,Nivet E,Sancho-Martinez I,Vitaloni M,Guenechea G,Xia Y,Kurian L,Dubova I,Bueren J,Laricchia-Robbio L,Belmonte JCI
Sat Nov 01 00:00:00 EDT 2014
Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming.
Stem cells (Dayton, Ohio)
Zdzieblo D,Li X,Lin Q,Zenke M,Illich DJ,Becker M,Müller AM
Mon Dec 01 00:00:00 EST 2014
Critical Roles for PU.1, GATA1, and GATA2 in the expression of human FcεRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2.
Journal of immunology (Baltimore, Md. : 1950)
Inage E,Kasakura K,Yashiro T,Suzuki R,Baba Y,Nakano N,Hara M,Tanabe A,Oboki K,Matsumoto K,Saito H,Niyonsaba F,Ohtsuka Y,Ogawa H,Okumura K,Shimizu T,Nishiyama C
Tue Apr 15 00:00:00 EDT 2014
Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation.
Journal of immunology (Baltimore, Md. : 1950)
Smrz D,Cruse G,Beaven MA,Kirshenbaum A,Metcalfe DD,Gilfillan AM
Mon Dec 15 00:00:00 EST 2014
Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Balan S,Ollion V,Colletti N,Chelbi R,Montanana-Sanchis F,Liu H,Vu Manh TP,Sanchez C,Savoret J,Perrot I,Doffin AC,Fossum E,Bechlian D,Chabannon C,Bogen B,Asselin-Paturel C,Shaw M,Soos T,Caux C,Valladeau-Guilemond J,Dalod M
Fri Aug 15 00:00:00 EDT 2014
3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase, promotes erythroid differentiation.
The Journal of biological chemistry
Fujiwara T,Saitoh H,Inoue A,Kobayashi M,Okitsu Y,Katsuoka Y,Fukuhara N,Onishi Y,Ishizawa K,Ichinohasama R,Harigae H
Fri Mar 21 00:00:00 EDT 2014
Regulation of Fc∈RI signaling in mast cells by G protein-coupled receptor kinase 2 and its RH domain.
The Journal of biological chemistry
Subramanian H,Gupta K,Parameswaran N,Ali H
Fri Jul 25 00:00:00 EDT 2014
Derivation of novel human ground state naive pluripotent stem cells.
Nature
Gafni O,Weinberger L,Mansour AA,Manor YS,Chomsky E,Ben-Yosef D,Kalma Y,Viukov S,Maza I,Zviran A,Rais Y,Shipony Z,Mukamel Z,Krupalnik V,Zerbib M,Geula S,Caspi I,Schneir D,Shwartz T,Gilad S,Amann-Zalcenstein D,Benjamin S,Amit I,Tanay A,Massarwa R,Novershtern N,Hanna JH
Thu Dec 12 00:00:00 EST 2013
Derivation of novel human ground state naive pluripotent stem cells.
Nature
Gafni O,Weinberger L,Mansour AA,Manor YS,Chomsky E,Ben-Yosef D,Kalma Y,Viukov S,Maza I,Zviran A,Rais Y,Shipony Z,Mukamel Z,Krupalnik V,Zerbib M,Geula S,Caspi I,Schneir D,Shwartz T,Gilad S,Amann-Zalcenstein D,Benjamin S,Amit I,Tanay A,Massarwa R,Novershtern N,Hanna JH
Thu Dec 12 00:00:00 EST 2013
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability.
Cell
King B,Trimarchi T,Reavie L,Xu L,Mullenders J,Ntziachristos P,Aranda-Orgilles B,Perez-Garcia A,Shi J,Vakoc C,Sandy P,Shen SS,Ferrando A,Aifantis I
Thu Jun 20 00:00:00 EDT 2013
Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.
Blood
Mace EM,Hsu AP,Monaco-Shawver L,Makedonas G,Rosen JB,Dropulic L,Cohen JI,Frenkel EP,Bagwell JC,Sullivan JL,Biron CA,Spalding C,Zerbe CS,Uzel G,Holland SM,Orange JS
Thu Apr 04 00:00:00 EDT 2013
RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.
Blood
Harada Y,Inoue D,Ding Y,Imagawa J,Doki N,Matsui H,Yahata T,Matsushita H,Ando K,Sashida G,Iwama A,Kitamura T,Harada H
Thu Apr 25 00:00:00 EDT 2013
CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age.
Blood
Gekas C,Graf T
Thu May 30 00:00:00 EDT 2013
SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.
Blood
Kung Sutherland MS,Walter RB,Jeffrey SC,Burke PJ,Yu C,Kostner H,Stone I,Ryan MC,Sussman D,Lyon RP,Zeng W,Harrington KH,Klussman K,Westendorf L,Meyer D,Bernstein ID,Senter PD,Benjamin DR,Drachman JG,McEarchern JA
Thu Aug 22 00:00:00 EDT 2013
Transgene-free iPSCs generated from small volume peripheral blood nonmobilized CD34+ cells.
Blood
Merling RK,Sweeney CL,Choi U,De Ravin SS,Myers TG,Otaizo-Carrasquero F,Pan J,Linton G,Chen L,Koontz S,Theobald NL,Malech HL
Thu Apr 04 00:00:00 EDT 2013
Role of SOX17 in hematopoietic development from human embryonic stem cells.
Blood
Nakajima-Takagi Y,Osawa M,Oshima M,Takagi H,Miyagi S,Endoh M,Endo TA,Takayama N,Eto K,Toyoda T,Koseki H,Nakauchi H,Iwama A
Thu Jan 17 00:00:00 EST 2013
Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells.
Blood
Bolton-Gillespie E,Schemionek M,Klein HU,Flis S,Hoser G,Lange T,Nieborowska-Skorska M,Maier J,Kerstiens L,Koptyra M,Müller MC,Modi H,Stoklosa T,Seferynska I,Bhatia R,Holyoake TL,Koschmieder S,Skorski T
Thu May 16 00:00:00 EDT 2013
Identification of the chemokine CCL28 as a growth and survival factor for human hematopoietic stem and progenitor cells.
Blood
Karlsson C,Baudet A,Miharada N,Soneji S,Gupta R,Magnusson M,Enver T,Karlsson G,Larsson J
Thu May 09 00:00:00 EDT 2013
PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway.
Blood
Kauskot A,Vandenbriele C,Louwette S,Gijsbers R,Tousseyn T,Freson K,Verhamme P,Hoylaerts MF
Thu Jun 27 00:00:00 EDT 2013
Genomic impact of transient low-dose decitabine treatment on primary AML cells.
Blood
Klco JM,Spencer DH,Lamprecht TL,Sarkaria SM,Wylie T,Magrini V,Hundal J,Walker J,Varghese N,Erdmann-Gilmore P,Lichti CF,Meyer MR,Townsend RR,Wilson RK,Mardis ER,Ley TJ
Thu Feb 28 00:00:00 EST 2013
Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions.
The Journal of clinical investigation
Aziz A,Baxter EJ,Edwards C,Cheong CY,Ito M,Bench A,Kelley R,Silber Y,Beer PA,Chng K,Renfree MB,McEwen K,Gray D,Nangalia J,Mufti GJ,Hellstrom-Lindberg E,Kiladjian JJ,McMullin MF,Campbell PJ,Ferguson-Smith AC,Green AR
Wed May 01 00:00:00 EDT 2013
Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.
The Journal of clinical investigation
Richardson CL,Delehanty LL,Bullock GC,Rival CM,Tung KS,Kimpel DL,Gardenghi S,Rivella S,Goldfarb AN
Thu Aug 01 00:00:00 EDT 2013
Notch pathway activation targets AML-initiating cell homeostasis and differentiation.
The Journal of experimental medicine
Lobry C,Ntziachristos P,Ndiaye-Lobry D,Oh P,Cimmino L,Zhu N,Araldi E,Hu W,Freund J,Abdel-Wahab O,Ibrahim S,Skokos D,Armstrong SA,Levine RL,Park CY,Aifantis I
Mon Feb 11 00:00:00 EST 2013
Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1.
Molecular therapy. Nucleic acids
Centlivre M,Legrand N,Klamer S,Liu YP,Jasmijn von Eije K,Bohne M,Rijnstra ES,Weijer K,Blom B,Voermans C,Spits H,Berkhout B
Tue Sep 03 00:00:00 EDT 2013
TNF-α has tropic rather than apoptotic activity in human hematopoietic progenitors: involvement of TNF receptor-1 and caspase-8.
Stem cells (Dayton, Ohio)
Mizrahi K,Stein J,Yaniv I,Kaplan O,Askenasy N
Tue Jan 01 00:00:00 EST 2013
β-Defensins activate human mast cells via Mas-related gene X2.
Journal of immunology (Baltimore, Md. : 1950)
Subramanian H,Gupta K,Lee D,Bayir AK,Ahn H,Ali H
Mon Jul 01 00:00:00 EDT 2013
Calcineurin-Rcan1 interaction contributes to stem cell factor-mediated mast cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Wu Z,Li Y,MacNeil AJ,Junkins RD,Berman JN,Lin TJ
Sun Dec 15 00:00:00 EST 2013
Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃.
Journal of immunology (Baltimore, Md. : 1950)
Sato T,Kitawaki T,Fujita H,Iwata M,Iyoda T,Inaba K,Ohteki T,Hasegawa S,Kawada K,Sakai Y,Ikeuchi H,Nakase H,Niwa A,Takaori-Kondo A,Kadowaki N
Sun Sep 15 00:00:00 EDT 2013
Cigarette smoke suppresses the surface expression of c-kit and FcεRI on mast cells.
Mediators of inflammation
Givi ME,Blokhuis BR,Da Silva CA,Adcock I,Garssen J,Folkerts G,Redegeld FA,Mortaz E
Mon Aug 19 00:00:00 EDT 2013
Expression of stem cell factor in gastrointestinal stromal tumors: Implications for proliferation and imatinib resistance.
Oncology letters
Hou XW,Bai CG,Liu XH,Qiu C,Huang L,Xu JJ,Ma DL
Fri Feb 01 00:00:00 EST 2013
Infusion of megakaryocytic progenitor products generated from cord blood hematopoietic stem/progenitor cells: results of the phase 1 study.
PloS one
Xi J,Zhu H,Liu D,Nan X,Zheng W,Liu K,Shi W,Chen L,Lv Y,Yan F,Li Y,Xie X,Wang Y,Yue W,Xu X,Wei X,Zhu J,Huang X,Pei X
Fri Jul 19 00:00:00 EDT 2013
Infusion of megakaryocytic progenitor products generated from cord blood hematopoietic stem/progenitor cells: results of the phase 1 study.
PloS one
Xi J,Zhu H,Liu D,Nan X,Zheng W,Liu K,Shi W,Chen L,Lv Y,Yan F,Li Y,Xie X,Wang Y,Yue W,Xu X,Wei X,Zhu J,Huang X,Pei X
Fri Jul 19 00:00:00 EDT 2013
Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.
PloS one
Pick M,Azzola L,Osborne E,Stanley EG,Elefanty AG
Thu Aug 08 00:00:00 EDT 2013
Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.
PloS one
Pick M,Azzola L,Osborne E,Stanley EG,Elefanty AG
Thu Aug 08 00:00:00 EDT 2013
Hematopoietic stem and progenitor cells acquire distinct DNA-hypermethylation during in vitro culture.
Scientific reports
Weidner CI,Walenda T,Lin Q,Wölfler MM,Denecke B,Costa IG,Zenke M,Wagner W
Thu Nov 28 00:00:00 EST 2013
Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.
PloS one
Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK
Wed Jul 03 00:00:00 EDT 2013
Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.
PloS one
Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK
Wed Jul 03 00:00:00 EDT 2013
PI3K/mTOR pathway inhibitors sensitize chronic myeloid leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem cell factor.
Cell death & disease
Airiau K,Mahon FX,Josselin M,Jeanneteau M,Belloc F
Thu Oct 03 00:00:00 EDT 2013
A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells.
PloS one
Gao XN,Lin J,Ning QY,Gao L,Yao YS,Zhou JH,Li YH,Wang LL,Yu L
Fri Jul 19 00:00:00 EDT 2013
A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells.
PloS one
Gao XN,Lin J,Ning QY,Gao L,Yao YS,Zhou JH,Li YH,Wang LL,Yu L
Fri Jul 19 00:00:00 EDT 2013
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.
Nature methods
Certo MT,Gwiazda KS,Kuhar R,Sather B,Curinga G,Mandt T,Brault M,Lambert AR,Baxter SK,Jacoby K,Ryu BY,Kiem HP,Gouble A,Paques F,Rawlings DJ,Scharenberg AM
Mon Oct 01 00:00:00 EDT 2012
FANCL ubiquitinates β-catenin and enhances its nuclear function.
Blood
Dao KH,Rotelli MD,Petersen CL,Kaech S,Nelson WD,Yates JE,Hanlon Newell AE,Olson SB,Druker BJ,Bagby GC
Thu Jul 12 00:00:00 EDT 2012
Down-regulated expression of hsa-miR-181c in Fanconi anemia patients: implications in TNFα regulation and proliferation of hematopoietic progenitor cells.
Blood
Río P,Agirre X,Garate L,Baños R,Álvarez L,San José-Enériz E,Badell I,Casado JA,Garín M,Prósper F,Bueren JA
Thu Mar 29 00:00:00 EDT 2012
RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion.
Blood
Baudet A,Karlsson C,Safaee Talkhoncheh M,Galeev R,Magnusson M,Larsson J
Thu Jun 28 00:00:00 EDT 2012
APELIN promotes hematopoiesis from human embryonic stem cells.
Blood
Yu QC,Hirst CE,Costa M,Ng ES,Schiesser JV,Gertow K,Stanley EG,Elefanty AG
Thu Jun 28 00:00:00 EDT 2012
Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.
The Journal of clinical investigation
Cesana D,Sgualdino J,Rudilosso L,Merella S,Naldini L,Montini E
Tue May 01 00:00:00 EDT 2012
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.
The Journal of experimental medicine
Thiollier C,Lopez CK,Gerby B,Ignacimouttou C,Poglio S,Duffourd Y,Guégan J,Rivera-Munoz P,Bluteau O,Mabialah V,Diop M,Wen Q,Petit A,Bauchet AL,Reinhardt D,Bornhauser B,Gautheret D,Lecluse Y,Landman-Parker J,Radford I,Vainchenker W,Dastugue N,de Botton S,Dessen P,Bourquin JP,Crispino JD,Ballerini P,Bernard OA,Pflumio F,Mercher T
Mon Oct 22 00:00:00 EDT 2012
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
The Journal of experimental medicine
Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H
Mon Oct 22 00:00:00 EDT 2012
Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression.
Nature protocols
Dowey SN,Huang X,Chou BK,Ye Z,Cheng L
300-07 was used in Cell Culture to describe a detailed, validated protocol for effective generation of integration-free human induced pluripotent stem cells from blood mononuclear cells by plasmid vectors.
Thu Nov 01 00:00:00 EDT 2012
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.
Proceedings of the National Academy of Sciences of the United States of America
Roy A,Cowan G,Mead AJ,Filippi S,Bohn G,Chaidos A,Tunstall O,Chan JK,Choolani M,Bennett P,Kumar S,Atkinson D,Wyatt-Ashmead J,Hu M,Stumpf MP,Goudevenou K,O'Connor D,Chou ST,Weiss MJ,Karadimitris A,Jacobsen SE,Vyas P,Roberts I
Tue Oct 23 00:00:00 EDT 2012
GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells.
Oncogene
Joha S,Nugues AL,Hétuin D,Berthon C,Dezitter X,Dauphin V,Mahon FX,Roche-Lestienne C,Preudhomme C,Quesnel B,Idziorek T
Thu Mar 15 00:00:00 EDT 2012
Intercellular cytosolic transfer correlates with mesenchymal stromal cell rescue of umbilical cord blood cell viability during ex vivo expansion.
Cytotherapy
Chu PP,Bari S,Fan X,Gay FP,Ang JM,Chiu GN,Lim SK,Hwang WY
Mon Oct 01 00:00:00 EDT 2012
Characterization and function of histamine receptors in human bone marrow stromal cells.
Stem cells (Dayton, Ohio)
Nemeth K,Wilson T,Rada B,Parmelee A,Mayer B,Buzas E,Falus A,Key S,Masszi T,Karpati S,Mezey E
Wed Feb 01 00:00:00 EST 2012
Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 culture system promote T-cell reconstitution in NOD/SCID/γc(-/-) mice.
Stem cells (Dayton, Ohio)
Reimann C,Six E,Dal-Cortivo L,Schiavo A,Appourchaux K,Lagresle-Peyrou C,de Chappedelaine C,Ternaux B,Coulombel L,Beldjord K,Cavazzana-Calvo M,Andre-Schmutz I
Wed Aug 01 00:00:00 EDT 2012
Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Bilwani FA,Knight KL
Thu Nov 01 00:00:00 EDT 2012
Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Bilwani FA,Knight KL
Thu Nov 01 00:00:00 EDT 2012
Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Bilwani FA,Knight KL
Thu Nov 01 00:00:00 EDT 2012
The aryl hydrocarbon receptor modulates acute and late mast cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Sibilano R,Frossi B,Calvaruso M,Danelli L,Betto E,Dall'Agnese A,Tripodo C,Colombo MP,Pucillo CE,Gri G
Sun Jul 01 00:00:00 EDT 2012
Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens.
Allergy, asthma & immunology research
Kashiwakura J,Okayama Y,Furue M,Kabashima K,Shimada S,Ra C,Siraganian RP,Kawakami Y,Kawakami T
Thu Nov 01 00:00:00 EDT 2012
Generation of virus-free induced pluripotent stem cell clones on a synthetic matrix via a single cell subcloning in the naïve state.
PloS one
Nishishita N,Shikamura M,Takenaka C,Takada N,Fusaki N,Kawamata S
Thu Dec 13 00:00:00 EST 2012
Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities.
PloS one
Aggarwal R,Lu J,Kanji S,Joseph M,Das M,Noble GJ,McMichael BK,Agarwal S,Hart RT,Sun Z,Lee BS,Rosol TJ,Jackson R,Mao HQ,Pompili VJ,Das H
Wed Dec 12 00:00:00 EST 2012
Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics.
PloS one
Danova-Alt R,Heider A,Egger D,Cross M,Alt R
Tue Aug 07 00:00:00 EDT 2012
Residual expression of the reprogramming factors prevents differentiation of iPSC generated from human fibroblasts and cord blood CD34+ progenitors.
PloS one
Ramos-Mejía V,Montes R,Bueno C,Ayllón V,Real PJ,Rodríguez R,Menendez P
Mon Aug 27 00:00:00 EDT 2012
Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model.
PloS one
Banerjee ER,Laflamme MA,Papayannopoulou T,Kahn M,Murry CE,Henderson WR
Fri Aug 03 00:00:00 EDT 2012
Inhibition of Mammalian target of rapamycin in human acute myeloid leukemia cells has diverse effects that depend on the environmental in vitro stress.
Bone marrow research
Ryningen A,Reikvam H,Nepstad I,Paulsen Rye K,Bruserud O
Mon Oct 22 00:00:00 EDT 2012
Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity.
The Journal of biological chemistry
Yang T,Jian W,Luo Y,Fu X,Noguchi C,Bungert J,Huang S,Qiu Y
Fri Nov 23 00:00:00 EST 2012
Direct chromatin PCR (DC-PCR): hypotonic conditions allow differentiation of chromatin states during thermal cycling.
PloS one
Vatolin S,Khan SN,Reu FJ
Tue Mar 12 00:00:00 EDT 2013
Pharmacological inhibition of caspase and calpain proteases: a novel strategy to enhance the homing responses of cord blood HSPCs during expansion.
PloS one
Sangeetha VM,Kadekar D,Kale VP,Limaye LS
Mon May 14 00:00:00 EDT 2012
Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells.
The Journal of biological chemistry
Gao H,Wu X,Sun Y,Zhou S,Silberstein LE,Zhu Z
Fri Aug 24 00:00:00 EDT 2012
Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation.
PloS one
Li XH,Ha CT,Fu D,Xiao M
Thu May 09 00:00:00 EDT 2013
Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells.
Blood cancer journal
Dassé E,Volpe G,Walton DS,Wilson N,Del Pozzo W,O'Neill LP,Slany RK,Frampton J,Dumon S
Fri Jun 01 00:00:00 EDT 2012
Anti-apoptotic BFL-1 is the major effector in activation-induced human mast cell survival.
PloS one
Ekoff M,Lyberg K,Krajewska M,Arvidsson M,Rak S,Reed JC,Harvima I,Nilsson G
Thu Dec 13 00:00:00 EST 2012
RNA sensors enable human mast cell anti-viral chemokine production and IFN-mediated protection in response to antibody-enhanced dengue virus infection.
PloS one
Brown MG,McAlpine SM,Huang YY,Haidl ID,Al-Afif A,Marshall JS,Anderson R
Mon Nov 05 00:00:00 EST 2012
Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications.
PloS one
Yamagata Y,Parietti V,Stockholm D,Corre G,Poinsignon C,Touleimat N,Delafoy D,Besse C,Tost J,Galy A,Paldi A
Wed Jul 24 00:00:00 EDT 2013
Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.
Cell
Bock C,Kiskinis E,Verstappen G,Gu H,Boulting G,Smith ZD,Ziller M,Croft GF,Amoroso MW,Oakley DH,Gnirke A,Eggan K,Meissner A
Fri Feb 04 00:00:00 EST 2011
NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes.
Nature methods
Elliott DA,Braam SR,Koutsis K,Ng ES,Jenny R,Lagerqvist EL,Biben C,Hatzistavrou T,Hirst CE,Yu QC,Skelton RJ,Ward-van Oostwaard D,Lim SM,Khammy O,Li X,Hawes SM,Davis RP,Goulburn AL,Passier R,Prall OW,Haynes JM,Pouton CW,Kaye DM,Mummery CL,Elefanty AG,Stanley EG
Sun Oct 23 00:00:00 EDT 2011
Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice.
Cell research
Lu SJ,Li F,Yin H,Feng Q,Kimbrel EA,Hahm E,Thon JN,Wang W,Italiano JE,Cho J,Lanza R
Tue Mar 01 00:00:00 EST 2011
Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia.
Cancer cell
Goardon N,Marchi E,Atzberger A,Quek L,Schuh A,Soneji S,Woll P,Mead A,Alford KA,Rout R,Chaudhury S,Gilkes A,Knapper S,Beldjord K,Begum S,Rose S,Geddes N,Griffiths M,Standen G,Sternberg A,Cavenagh J,Hunter H,Bowen D,Killick S,Robinson L,Price A,Macintyre E,Virgo P,Burnett A,Craddock C,Enver T,Jacobsen SE,Porcher C,Vyas P
Tue Jan 18 00:00:00 EST 2011
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell
Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R
Tue Sep 13 00:00:00 EDT 2011
JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation.
Cancer cell
Liu F,Zhao X,Perna F,Wang L,Koppikar P,Abdel-Wahab O,Harr MW,Levine RL,Xu H,Tefferi A,Deblasio A,Hatlen M,Menendez S,Nimer SD
Tue Feb 15 00:00:00 EST 2011
Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments.
Blood
Gibbs KD,Gilbert PM,Sachs K,Zhao F,Blau HM,Weissman IL,Nolan GP,Majeti R
Thu Apr 21 00:00:00 EDT 2011
Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia.
Blood
Montes R,Ayllón V,Gutierrez-Aranda I,Prat I,Hernández-Lamas MC,Ponce L,Bresolin S,Te Kronnie G,Greaves M,Bueno C,Menendez P
Thu May 05 00:00:00 EDT 2011
BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription.
Blood
Sheng Z,Ma L,Sun JE,Zhu LJ,Green MR
Thu Sep 08 00:00:00 EDT 2011
Proof of principle for transfusion of in vitro-generated red blood cells.
Blood
Giarratana MC,Rouard H,Dumont A,Kiger L,Safeukui I,Le Pennec PY,François S,Trugnan G,Peyrard T,Marie T,Jolly S,Hebert N,Mazurier C,Mario N,Harmand L,Lapillonne H,Devaux JY,Douay L
Thu Nov 10 00:00:00 EST 2011
Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.
Blood
Sun H,Kapuria V,Peterson LF,Fang D,Bornmann WG,Bartholomeusz G,Talpaz M,Donato NJ
Thu Mar 17 00:00:00 EDT 2011
Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.
Blood
Chen TH,Kambal A,Krysiak K,Walshauser MA,Raju G,Tibbitts JF,Walter MJ
Thu Feb 03 00:00:00 EST 2011
TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms.
Blood
Fleischman AG,Aichberger KJ,Luty SB,Bumm TG,Petersen CL,Doratotaj S,Vasudevan KB,LaTocha DH,Yang F,Press RD,Loriaux MM,Pahl HL,Silver RT,Agarwal A,O'Hare T,Druker BJ,Bagby GC,Deininger MW
Thu Dec 08 00:00:00 EST 2011
Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.
Blood
Bouma G,Mendoza-Naranjo A,Blundell MP,de Falco E,Parsley KL,Burns SO,Thrasher AJ
Thu Sep 01 00:00:00 EDT 2011
Dendritic cells with lymphocyte-stimulating activity differentiate from human CD133 positive precursors.
Blood
Bonetti MI,Pieri L,Domenici L,Urbani S,Romano G,Aldinucci A,Ballerini C,Monici M,Saccardi R,Basile V,Bosi A,Romagnoli P
Thu Apr 14 00:00:00 EDT 2011
Sox6 enhances erythroid differentiation in human erythroid progenitors.
Blood
Cantù C,Ierardi R,Alborelli I,Fugazza C,Cassinelli L,Piconese S,Bosè F,Ottolenghi S,Ferrari G,Ronchi A
Thu Mar 31 00:00:00 EDT 2011
Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells.
Blood
Hu K,Yu J,Suknuntha K,Tian S,Montgomery K,Choi KD,Stewart R,Thomson JA,Slukvin II
Thu Apr 07 00:00:00 EDT 2011
Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow.
Blood
Matthes T,Dunand-Sauthier I,Santiago-Raber ML,Krause KH,Donze O,Passweg J,McKee T,Huard B
Thu Aug 18 00:00:00 EDT 2011
HTLV-1 propels thymic human T cell development in "human immune system" Rag2⁻/⁻ gamma c⁻/⁻ mice.
PLoS pathogens
Villaudy J,Wencker M,Gadot N,Gillet NA,Scoazec JY,Gazzolo L,Manz MG,Bangham CR,Dodon MD
Thu Sep 01 00:00:00 EDT 2011
Tight control of STAT5 activity determines human CD34-derived interstitial dendritic cell and langerhans cell development.
Journal of immunology (Baltimore, Md. : 1950)
van de Laar L,van den Bosch A,Wierenga AT,Janssen HL,Coffer PJ,Woltman AM
Wed Jun 15 00:00:00 EDT 2011
Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Rådinger M,Smrž D,Metcalfe DD,Gilfillan AM
Thu Dec 01 00:00:00 EST 2011
Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors.
PloS one
Mack AA,Kroboth S,Rajesh D,Wang WB
Mon Apr 02 00:00:00 EDT 2012
Hypoxia selects bortezomib-resistant stem cells of chronic myeloid leukemia.
PloS one
Tanturli M,Giuntoli S,Barbetti V,Rovida E,Dello Sbarba P
Fri Feb 11 00:00:00 EST 2011
Generation of bivalent chromatin domains during cell fate decisions.
Epigenetics & chromatin
De Gobbi M,Garrick D,Lynch M,Vernimmen D,Hughes JR,Goardon N,Luc S,Lower KM,Sloane-Stanley JA,Pina C,Soneji S,Renella R,Enver T,Taylor S,Jacobsen SE,Vyas P,Gibbons RJ,Higgs DR
Mon Jun 06 00:00:00 EDT 2011
Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia.
Blood cancer journal
Skavland J,Jørgensen KM,Hadziavdic K,Hovland R,Jonassen I,Bruserud O,Gjertsen BT
Tue Feb 01 00:00:00 EST 2011
Aconitase regulation of erythropoiesis correlates with a novel licensing function in erythropoietin-induced ERK signaling.
PloS one
Talbot AL,Bullock GC,Delehanty LL,Sattler M,Zhao ZJ,Goldfarb AN
Fri Feb 24 00:00:00 EST 2012
Immunoglobulin E oligomers identified in blood components activate mast cells: relevance to anaphylactic transfusion reaction.
Transfusion
Abe T,Matsumoto C,Shimada E,Mazda T,Takanashi M,Kawaguchi K,Hamasaki T,Mita H,Akiyama K,Okazaki H,Satake M,Tadokoro K
300-07 was used in Cell Culture to suggest that these IgEs were dimeric and trimeric and that they directly activated the transfusion recipient's mast cells by triggering the crosslinking of Fcε receptor I, thereby inducing an anaphylactic transfusion reaction.
Tue Nov 01 00:00:00 EDT 2011
Comparative study of hematopoietic differentiation between human embryonic stem cell lines.
PloS one
Melichar H,Li O,Ross J,Haber H,Cado D,Nolla H,Robey EA,Winoto A
Fri Oct 21 00:00:00 EDT 2011
Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.
The Journal of biological chemistry
Sarma NJ,Yaseen NR
Fri Nov 11 00:00:00 EST 2011
Phosphoproteomic analysis of apoptotic hematopoietic stem cells from hemoglobin E/β-thalassemia.
Journal of translational medicine
Ponnikorn S,Panichakul T,Sresanga K,Wongborisuth C,Roytrakul S,Hongeng S,Tungpradabkul S
Sat Jun 25 00:00:00 EDT 2011
Efficient feeder-free episomal reprogramming with small molecules.
PloS one
Yu J,Chau KF,Vodyanik MA,Jiang J,Jiang Y
Tue Mar 01 00:00:00 EST 2011
Eos negatively regulates human γ-globin gene transcription during erythroid differentiation.
PloS one
Yu HC,Zhao HL,Wu ZK,Zhang JW
Tue Dec 06 00:00:00 EST 2011
Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming.
The Journal of biological chemistry
Nishimura K,Sano M,Ohtaka M,Furuta B,Umemura Y,Nakajima Y,Ikehara Y,Kobayashi T,Segawa H,Takayasu S,Sato H,Motomura K,Uchida E,Kanayasu-Toyoda T,Asashima M,Nakauchi H,Yamaguchi T,Nakanishi M
Fri Feb 11 00:00:00 EST 2011
Congenital dyserythropoietic anemia type II: molecular analysis and expression of the SEC23B gene.
Orphanet journal of rare diseases
Punzo F,Bertoli-Avella AM,Scianguetta S,Della Ragione F,Casale M,Ronzoni L,Cappellini MD,Forni G,Oostra BA,Perrotta S
Fri Dec 30 00:00:00 EST 2011
Human fetal liver: an in vitro model of erythropoiesis.
Stem cells international
Pourcher G,Mazurier C,King YY,Giarratana MC,Kobari L,Boehm D,Douay L,Lapillonne H
Thu Nov 10 00:00:00 EST 2011
Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization.
The Journal of biological chemistry
Subramanian H,Gupta K,Guo Q,Price R,Ali H
Fri Dec 30 00:00:00 EST 2011
Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells.
PloS one
Vibhuti A,Gupta K,Subramanian H,Guo Q,Ali H
Thu May 12 00:00:00 EDT 2011
Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases.
PloS one
Guo Q,Subramanian H,Gupta K,Ali H
Tue Dec 06 00:00:00 EST 2011
Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia.
Nature
Cavazzana-Calvo M,Payen E,Negre O,Wang G,Hehir K,Fusil F,Down J,Denaro M,Brady T,Westerman K,Cavallesco R,Gillet-Legrand B,Caccavelli L,Sgarra R,Maouche-Chrétien L,Bernaudin F,Girot R,Dorazio R,Mulder GJ,Polack A,Bank A,Soulier J,Larghero J,Kabbara N,Dalle B,Gourmel B,Socie G,Chrétien S,Cartier N,Aubourg P,Fischer A,Cornetta K,Galacteros F,Beuzard Y,Gluckman E,Bushman F,Hacein-Bey-Abina S,Leboulch P
Thu Sep 16 00:00:00 EDT 2010
β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.
Cancer cell
Yeung J,Esposito MT,Gandillet A,Zeisig BB,Griessinger E,Bonnet D,So CW
Tue Dec 14 00:00:00 EST 2010
The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome.
Blood
Prebet T,Lhoumeau AC,Arnoulet C,Aulas A,Marchetto S,Audebert S,Puppo F,Chabannon C,Sainty D,Santoni MJ,Sebbagh M,Summerour V,Huon Y,Shin WS,Lee ST,Esterni B,Vey N,Borg JP
Thu Sep 30 00:00:00 EDT 2010
The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome.
Blood
Prebet T,Lhoumeau AC,Arnoulet C,Aulas A,Marchetto S,Audebert S,Puppo F,Chabannon C,Sainty D,Santoni MJ,Sebbagh M,Summerour V,Huon Y,Shin WS,Lee ST,Esterni B,Vey N,Borg JP
Thu Sep 30 00:00:00 EDT 2010
The first trimester human placenta is a site for terminal maturation of primitive erythroid cells.
Blood
Van Handel B,Prashad SL,Hassanzadeh-Kiabi N,Huang A,Magnusson M,Atanassova B,Chen A,Hamalainen EI,Mikkola HK
Thu Oct 28 00:00:00 EDT 2010
Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.
Blood
Agerstam H,Järås M,Andersson A,Johnels P,Hansen N,Lassen C,Rissler M,Gisselsson D,Olofsson T,Richter J,Fan X,Ehinger M,Fioretos T
Thu Sep 23 00:00:00 EDT 2010
Iron control of erythroid development by a novel aconitase-associated regulatory pathway.
Blood
Bullock GC,Delehanty LL,Talbot AL,Gonias SL,Tong WH,Rouault TA,Dewar B,Macdonald JM,Chruma JJ,Goldfarb AN
Thu Jul 08 00:00:00 EDT 2010
Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors.
Blood
Yu C,Liu Y,Miao Z,Yin M,Lu W,Lv Y,Ding M,Deng H
Thu Dec 02 00:00:00 EST 2010
Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera.
Blood
Perna F,Gurvich N,Hoya-Arias R,Abdel-Wahab O,Levine RL,Asai T,Voza F,Menendez S,Wang L,Liu F,Zhao X,Nimer SD
Thu Oct 14 00:00:00 EDT 2010
The BH3-mimetic ABT-737 induces mast cell apoptosis in vitro and in vivo: potential for therapeutics.
Journal of immunology (Baltimore, Md. : 1950)
Karlberg M,Ekoff M,Huang DC,Mustonen P,Harvima IT,Nilsson G
Sun Aug 15 00:00:00 EDT 2010
Protein tyrosine nitration of aldolase in mast cells: a plausible pathway in nitric oxide-mediated regulation of mast cell function.
Journal of immunology (Baltimore, Md. : 1950)
Sekar Y,Moon TC,Slupsky CM,Befus AD
Thu Jul 01 00:00:00 EDT 2010
A nonredundant role for canonical NF-κB in human myeloid dendritic cell development and function.
Journal of immunology (Baltimore, Md. : 1950)
van de Laar L,van den Bosch A,van der Kooij SW,Janssen HL,Coffer PJ,van Kooten C,Woltman AM
Wed Dec 15 00:00:00 EST 2010
Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling.
Journal of immunology (Baltimore, Md. : 1950)
van de Laar L,Buitenhuis M,Wensveen FM,Janssen HL,Coffer PJ,Woltman AM
Tue Jun 15 00:00:00 EDT 2010
IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Macey MR,Sturgill JL,Morales JK,Falanga YT,Morales J,Norton SK,Yerram N,Shim H,Fernando J,Gifillan AM,Gomez G,Schwartz L,Oskeritzian C,Spiegel S,Conrad D,Ryan JJ
Sat May 01 00:00:00 EDT 2010
Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Rådinger M,Kuehn HS,Kim MS,Metcalfe DD,Gilfillan AM
Fri Jan 15 00:00:00 EST 2010
Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.
Journal of immunology (Baltimore, Md. : 1950)
Lee SH,Yun S,Piao ZH,Jeong M,Kim DO,Jung H,Lee J,Kim MJ,Kim MS,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I
Thu Jul 15 00:00:00 EDT 2010
CXCR7 protein is not expressed on human or mouse leukocytes.
Journal of immunology (Baltimore, Md. : 1950)
Berahovich RD,Zabel BA,Penfold ME,Lewén S,Wang Y,Miao Z,Gan L,Pereda J,Dias J,Slukvin II,McGrath KE,Jaen JC,Schall TJ
Mon Nov 01 00:00:00 EDT 2010
CXCR7 protein is not expressed on human or mouse leukocytes.
Journal of immunology (Baltimore, Md. : 1950)
Berahovich RD,Zabel BA,Penfold ME,Lewén S,Wang Y,Miao Z,Gan L,Pereda J,Dias J,Slukvin II,McGrath KE,Jaen JC,Schall TJ
Mon Nov 01 00:00:00 EDT 2010
CD72 negatively regulates KIT-mediated responses in human mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Kataoka TR,Kumanogoh A,Bandara G,Metcalfe DD,Gilfillan AM
Mon Mar 01 00:00:00 EST 2010
T cell-induced mast cell activation: a role for microparticles released from activated T cells.
Journal of immunology (Baltimore, Md. : 1950)
Shefler I,Salamon P,Reshef T,Mor A,Mekori YA
Fri Oct 01 00:00:00 EDT 2010
Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Niyonsaba F,Ushio H,Hara M,Yokoi H,Tominaga M,Takamori K,Kajiwara N,Saito H,Nagaoka I,Ogawa H,Okumura K
Thu Apr 01 00:00:00 EDT 2010
miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation.
Journal of immunology (Baltimore, Md. : 1950)
Jurkin J,Schichl YM,Koeffel R,Bauer T,Richter S,Konradi S,Gesslbauer B,Strobl H
Sat May 01 00:00:00 EDT 2010
Development of lentiviral vectors with optimized transcriptional activity for the gene therapy of patients with Fanconi anemia.
Human gene therapy
González-Murillo A,Lozano ML,Alvarez L,Jacome A,Almarza E,Navarro S,Segovia JC,Hanenberg H,Guenechea G,Bueren JA,Río P
Sat May 01 00:00:00 EDT 2010
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.
BMC immunology
Ersvaer E,Liseth K,Skavland J,Gjertsen BT,Bruserud Ø
Fri Jul 09 00:00:00 EDT 2010
Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells.
The Journal of biological chemistry
Chang YI,Hua WK,Yao CL,Hwang SM,Hung YC,Kuan CJ,Leou JS,Lin WJ
Fri Jul 02 00:00:00 EDT 2010
Expansion of cord blood CD34 cells in presence of zVADfmk and zLLYfmk improved their in vitro functionality and in vivo engraftment in NOD/SCID mouse.
PloS one
V M S,Kale VP,Limaye LS
Tue Aug 17 00:00:00 EDT 2010
Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells.
PloS one
Valeri A,Alonso-Ferrero ME,Río P,Pujol MR,Casado JA,Pérez L,Jacome A,Agirre X,Calasanz MJ,Hanenberg H,Surrallés J,Prosper F,Albella B,Bueren JA
Tue Dec 28 00:00:00 EST 2010
Erythroid progenitor cells expanded from peripheral blood without mobilization or preselection: molecular characteristics and functional competence.
PloS one
Filippone C,Franssila R,Kumar A,Saikko L,Kovanen PE,Söderlund-Venermo M,Hedman K
Tue Mar 02 00:00:00 EST 2010
Generation of induced pluripotent stem cells from human cord blood cells with only two factors: Oct4 and Sox2.
Nature protocols
Giorgetti A,Montserrat N,Rodriguez-Piza I,Azqueta C,Veiga A,Izpisúa Belmonte JC
Thu Apr 01 00:00:00 EDT 2010
In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AML.
PloS one
Abdul-Nabi AM,Yassin ER,Varghese N,Deshmukh H,Yaseen NR
Fri Aug 27 00:00:00 EDT 2010
ErythRED, a hESC line enabling identification of erythroid cells.
Nature methods
Hatzistavrou T,Micallef SJ,Ng ES,Vadolas J,Stanley EG,Elefanty AG
Tue Sep 01 00:00:00 EDT 2009
Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity.
Blood
Woll PS,Grzywacz B,Tian X,Marcus RK,Knorr DA,Verneris MR,Kaufman DS
Thu Jun 11 00:00:00 EDT 2009
Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome.
Blood
Will B,Kawahara M,Luciano JP,Bruns I,Parekh S,Erickson-Miller CL,Aivado MA,Verma A,Steidl U
Thu Oct 29 00:00:00 EDT 2009
AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms.
Blood
Ding Y,Harada Y,Imagawa J,Kimura A,Harada H
Thu Dec 10 00:00:00 EST 2009
Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells.
Blood
McKinney-Freeman SL,Naveiras O,Yates F,Loewer S,Philitas M,Curran M,Park PJ,Daley GQ
Thu Jul 09 00:00:00 EDT 2009
The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells.
Blood
Oehler VG,Guthrie KA,Cummings CL,Sabo K,Wood BL,Gooley T,Yang T,Epping MT,Shou Y,Pogosova-Agadjanyan E,Ladne P,Stirewalt DL,Abkowitz JL,Radich JP
Thu Oct 08 00:00:00 EDT 2009
Role for MKL1 in megakaryocytic maturation.
Blood
Cheng EC,Luo Q,Bruscia EM,Renda MJ,Troy JA,Massaro SA,Tuck D,Schulz V,Mane SM,Berliner N,Sun Y,Morris SW,Qiu C,Krause DS
Thu Mar 19 00:00:00 EDT 2009
Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.
Blood
Kandilci A,Grosveld GC
Thu Aug 20 00:00:00 EDT 2009
Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells.
Blood
Awong G,Herer E,Surh CD,Dick JE,La Motte-Mohs RN,Zúñiga-Pflücker JC
Thu Jul 30 00:00:00 EDT 2009
Generation of induced pluripotent stem cells from human blood.
Blood
Loh YH,Agarwal S,Park IH,Urbach A,Huo H,Heffner GC,Kim K,Miller JD,Ng K,Daley GQ
Thu May 28 00:00:00 EDT 2009
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis.
Blood
Pendino F,Nguyen E,Jonassen I,Dysvik B,Azouz A,Lanotte M,Ségal-Bendirdjian E,Lillehaug JR
Thu Apr 02 00:00:00 EDT 2009
Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation.
Blood
Göbel F,Taschner S,Jurkin J,Konradi S,Vaculik C,Richter S,Kneidinger D,Mühlbacher C,Bieglmayer C,Elbe-Bürger A,Strobl H
Thu Oct 29 00:00:00 EDT 2009
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.
Blood
Eberhard Y,McDermott SP,Wang X,Gronda M,Venugopal A,Wood TE,Hurren R,Datti A,Batey RA,Wrana J,Antholine WE,Dick JE,Schimmer AD
Thu Oct 01 00:00:00 EDT 2009
The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.
The Journal of clinical investigation
Ford AM,Palmi C,Bueno C,Hong D,Cardus P,Knight D,Cazzaniga G,Enver T,Greaves M
Wed Apr 01 00:00:00 EDT 2009
MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization.
The Journal of clinical investigation
Vagima Y,Avigdor A,Goichberg P,Shivtiel S,Tesio M,Kalinkovich A,Golan K,Dar A,Kollet O,Petit I,Perl O,Rosenthal E,Resnick I,Hardan I,Gellman YN,Naor D,Nagler A,Lapidot T
Sun Mar 01 00:00:00 EST 2009
Hyperexpression of NOD2 in intestinal mast cells of Crohn's disease patients: preferential expression of inflammatory cell-recruiting molecules via NOD2 in mast cells.
Clinical immunology (Orlando, Fla.)
Okumura S,Yuki K,Kobayashi R,Okamura S,Ohmori K,Saito H,Ra C,Okayama Y
Sun Feb 01 00:00:00 EST 2009
Tumor immunotherapy using gene-modified human mesenchymal stem cells loaded into synthetic extracellular matrix scaffolds.
Stem cells (Dayton, Ohio)
Compte M,Cuesta AM,Sánchez-Martín D,Alonso-Camino V,Vicario JL,Sanz L,Alvarez-Vallina L
Sun Mar 01 00:00:00 EST 2009
Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells.
Stem cells (Dayton, Ohio)
Tian X,Hexum MK,Penchev VR,Taylor RJ,Shultz LD,Kaufman DS
Sun Nov 01 00:00:00 EDT 2009
A feeder-free and efficient production of functional neutrophils from human embryonic stem cells.
Stem cells (Dayton, Ohio)
Saeki K,Saeki K,Nakahara M,Matsuyama S,Nakamura N,Yogiashi Y,Yoneda A,Koyanagi M,Kondo Y,Yuo A
Thu Jan 01 00:00:00 EST 2009
Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Platzer B,Richter S,Kneidinger D,Waltenberger D,Woisetschläger M,Strobl H
Wed Jul 01 00:00:00 EDT 2009
IgE-FcepsilonRI interactions determine HIV coreceptor usage and susceptibility to infection during ontogeny of mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Sundstrom JB,Hair GA,Ansari AA,Secor WE,Gilfillan AM,Metcalfe DD,Kirshenbaum AS
Fri May 15 00:00:00 EDT 2009
IL-7 enhances thymic human T cell development in "human immune system" Rag2-/-IL-2Rgammac-/- mice without affecting peripheral T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
van Lent AU,Dontje W,Nagasawa M,Siamari R,Bakker AQ,Pouw SM,Maijoor KA,Weijer K,Cornelissen JJ,Blom B,Di Santo JP,Spits H,Legrand N
Tue Dec 15 00:00:00 EST 2009
Dexamethasone and FK506 inhibit expression of distinct subsets of chemokines in human mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Kato A,Chustz RT,Ogasawara T,Kulka M,Saito H,Schleimer RP,Matsumoto K
Mon Jun 01 00:00:00 EDT 2009
The cathelicidin LL-37 activates human mast cells and is degraded by mast cell tryptase: counter-regulation by CXCL4.
Journal of immunology (Baltimore, Md. : 1950)
Schiemann F,Brandt E,Gross R,Lindner B,Mittelstädt J,Sommerhoff CP,Schulmistrat J,Petersen F
Sat Aug 15 00:00:00 EDT 2009
The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells.
Journal of immunology (Baltimore, Md. : 1950)
Boehmler AM,Drost A,Jaggy L,Seitz G,Wiesner T,Denzlinger C,Kanz L,Möhle R
Mon Jun 01 00:00:00 EDT 2009
RasGRP1 is required for human NK cell function.
Journal of immunology (Baltimore, Md. : 1950)
Lee SH,Yun S,Lee J,Kim MJ,Piao ZH,Jeong M,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I
Tue Dec 15 00:00:00 EST 2009
Kinetics and effect of integrin expression on human CD34(+) cells during murine leukemia virus-derived retroviral transduction with recombinant fibronectin for stem cell gene therapy.
Human gene therapy
Horiuchi Y,Onodera M,Miyagawa Y,Sato B,Onda K,Katagiri YU,Okita H,Okada M,Otsu M,Kume A,Okuyama T,Fujimoto J,Kuratsuji T,Kiyokawa N
Wed Jul 01 00:00:00 EDT 2009
Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model.
PloS one
Das H,George JC,Joseph M,Das M,Abdulhameed N,Blitz A,Khan M,Sakthivel R,Mao HQ,Hoit BD,Kuppusamy P,Pompili VJ
Wed Oct 07 00:00:00 EDT 2009
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.
PloS one
Robert G,Ben Sahra I,Puissant A,Colosetti P,Belhacene N,Gounon P,Hofman P,Bost F,Cassuto JP,Auberger P
Wed Nov 18 00:00:00 EST 2009
Human mast cell activation with virus-associated stimuli leads to the selective chemotaxis of natural killer cells by a CXCL8-dependent mechanism.
Blood
Burke SM,Issekutz TB,Mohan K,Lee PW,Shmulevitz M,Marshall JS
Sun Jun 15 00:00:00 EDT 2008
Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors.
Blood
Takayama N,Nishikii H,Usui J,Tsukui H,Sawaguchi A,Hiroyama T,Eto K,Nakauchi H
Sun Jun 01 00:00:00 EDT 2008
Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions.
Clinical cancer research : an official journal of the American Association for Cancer Research
Su Z,Frye C,Bae KM,Kelley V,Vieweg J
Wed Oct 01 00:00:00 EDT 2008
Identification of a small subpopulation of candidate leukemia-initiating cells in the side population of patients with acute myeloid leukemia.
Stem cells (Dayton, Ohio)
Moshaver B,van Rhenen A,Kelder A,van der Pol M,Terwijn M,Bachas C,Westra AH,Ossenkoppele GJ,Zweegman S,Schuurhuis GJ
Mon Dec 01 00:00:00 EST 2008
The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Kuehn HS,Swindle EJ,Kim MS,Beaven MA,Metcalfe DD,Gilfillan AM
Mon Dec 01 00:00:00 EST 2008
Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A.
Journal of immunology (Baltimore, Md. : 1950)
Prasad P,Yanagihara AA,Small-Howard AL,Turner H,Stokes AJ
Wed Oct 01 00:00:00 EDT 2008
Hematopoietic progenitor cells and interleukin-stimulated endothelium: expansion and differentiation of myeloid precursors.
BMC immunology
Moldenhauer A,Genter G,Lun A,Bal G,Kiesewetter H,Salama A
Wed Oct 01 00:00:00 EDT 2008
Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition.
BMC immunology
Kirshenbaum AS,Swindle E,Kulka M,Wu Y,Metcalfe DD
Thu Aug 07 00:00:00 EDT 2008
Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon.
Oncogene
Rigby RJ,Simmons JG,Greenhalgh CJ,Alexander WS,Lund PK
Thu Jul 19 00:00:00 EDT 2007
Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Sawamukai N,Saito K,Yamaoka K,Nakayamada S,Ra C,Tanaka Y
300-07 was used in Cell Culture to indicate a new way of controlling mast cells and may therefore be the basis for innovative approaches to the treatment of various diseases related to mast cells.
Thu Nov 15 00:00:00 EST 2007
Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G.
Blood
Schiemann F,Grimm TA,Hoch J,Gross R,Lindner B,Petersen F,Bulfone-Paus S,Brandt E
Wed Mar 15 00:00:00 EST 2006
Culture of human mast cells from hemopoietic progenitors.
Methods in molecular biology (Clifton, N.J.)
Saito H
300-07 was used in Cell Culture to introduce the method of forming human mast cell colonies by culturing purified cord blood cells and peripheral blood cells in serum-free methylcellulose supplemented with stem cell factor and interleukin-6 for 6 wk.
Tue Dec 06 00:00:00 EST 2005
Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.
The Journal of experimental medicine
Weller CL,Collington SJ,Brown JK,Miller HR,Al-Kashi A,Clark P,Jose PJ,Hartnell A,Williams TJ
Mon Jun 20 00:00:00 EDT 2005
Are interleukin-16 and thrombopoietin new tools for the in vitro generation of dendritic cells?
Blood
Della Bella S,Nicola S,Timofeeva I,Villa ML,Santoro A,Berardi AC
Wed Dec 15 00:00:00 EST 2004
Enhanced protein profiling arrays with ELISA-based amplification for high-throughput molecular changes of tumor patients' plasma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Huang R,Lin Y,Shi Q,Flowers L,Ramachandran S,Horowitz IR,Parthasarathy S,Huang RP
Thu Jan 15 00:00:00 EST 2004
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.
Cancer research
Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT
Sat Feb 15 00:00:00 EST 2003
Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcepsilon receptor I cross-linking: an interspecies comparison.
Blood
Nakajima T,Inagaki N,Tanaka H,Tanaka A,Yoshikawa M,Tamari M,Hasegawa K,Matsumoto K,Tachimoto H,Ebisawa M,Tsujimoto G,Matsuda H,Nagai H,Saito H
Sun Dec 01 00:00:00 EST 2002
Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells.
Blood
Burger PE,Coetzee S,McKeehan WL,Kan M,Cook P,Fan Y,Suda T,Hebbel RP,Novitzky N,Muller WA,Wilson EL
Fri Nov 15 00:00:00 EST 2002
