Product References
Generation and characterization of NGLY1 patient-derived midbrain organoids.
Frontiers in cell and developmental biology
Abbott J,Tambe M,Pavlinov I,Farkhondeh A,Nguyen HN,Xu M,Pradhan M,York T,Might M,Baumgärtel K,Rodems S,Zheng W
100-45 was used in Cell Culture to provide a relevant NGLY1 disease model to investigate disease mechanisms and evaluate therapeutics for treatments of NGLY1 deficiency.
Tue Mar 07 00:00:00 EST 2023
Spotting-based differentiation of functional dopaminergic progenitors from human pluripotent stem cells.
Nature protocols
Kim J,Jeon J,Song B,Lee N,Ko S,Cha Y,Leblanc P,Seo H,Kim KS
100-45 was used in Cell Culture to present a protocol detailing how to grow hPSCs such as human induced pluripotent and embryonic stem cells in a physically confined area ('spot') and efficiently differentiate them into a highly enriched population of healthy and functional midbrain dopamine progenitors (mDAPs) and midbrain dopamine neurons (mDANs).
Tue Mar 01 00:00:00 EST 2022
Stage-Specific Generation of Human Pluripotent Stem Cell Derived Lung Models to Measure CFTR Function.
Current protocols
Ngan SY,Quach HT,Laselva O,Huang EN,Mangos M,Xia S,Bear CE,Wong AP
Sat Jan 01 00:00:00 EST 2022
Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates.
Acta neuropathologica communications
Gao FJ,Klinedinst D,Fernandez FX,Cheng B,Savonenko A,Devenney B,Li Y,Wu D,Pomper MG,Reeves RH
100-45 was used in Western Blotting to study Shh overexpression in Down Syndrome brains and the effects on integrity and learning.
Mon Aug 16 00:00:00 EDT 2021
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Nature communications
Hu D,Sun X,Magpusao A,Fedorov Y,Thompson M,Wang B,Lundberg K,Adams DJ,Qi X
Mon Sep 06 00:00:00 EDT 2021
Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.
Cell reports. Medicine
Pandya NJ,Wang C,Costa V,Lopatta P,Meier S,Zampeta FI,Punt AM,Mientjes E,Grossen P,Distler T,Tzouros M,Martí Y,Banfai B,Patsch C,Rasmussen S,Hoener M,Berrera M,Kremer T,Dunkley T,Ebeling M,Distel B,Elgersma Y,Jagasia R
Tue Aug 17 00:00:00 EDT 2021
Direct conversion of human fibroblasts into dopaminergic neuron-like cells using small molecules and protein factors.
Military Medical Research
Qin H,Zhao AD,Sun ML,Ma K,Fu XB
100-45 was used in Sample Preparation to develope a chemical cocktail of small molecules and protein factors to convert human fibroblasts into DA neuron-like cells without passing through a neural progenitor/stem cell intermediate stage.
Sun Nov 01 00:00:00 EDT 2020
Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production.
Developmental cell
Frame JM,Kubaczka C,Long TL,Esain V,Soto RA,Hachimi M,Jing R,Shwartz A,Goessling W,Daley GQ,North TE
100-45 was used in In vitro experiments to establish the inflammasome as a conserved metabolic sensor that expands HSPC production in vivo and in vitro.
Mon Oct 26 00:00:00 EDT 2020
Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson's disease models.
Cell death & disease
Zhuang XX,Wang SF,Tan Y,Song JX,Zhu Z,Wang ZY,Wu MY,Cai CZ,Huang ZJ,Tan JQ,Su HX,Li M,Lu JH
Tue Feb 18 00:00:00 EST 2020
Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling.
Cell death & disease
Ke M,Chong CM,Zeng H,Huang M,Huang Z,Zhang K,Cen X,Lu JH,Yao X,Qin D,Su H
Tue Feb 18 00:00:00 EST 2020
BrainPhys neuronal medium optimized for imaging and optogenetics in vitro.
Nature communications
Zabolocki M,McCormack K,van den Hurk M,Milky B,Shoubridge AP,Adams R,Tran J,Mahadevan-Jansen A,Reineck P,Thomas J,Hutchinson MR,Mak CKH,Añonuevo A,Chew LH,Hirst AJ,Lee VM,Knock E,Bardy C
Tue Nov 03 00:00:00 EST 2020
Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy.
Clinical & translational immunology
Ebert LM,Yu W,Gargett T,Toubia J,Kollis PM,Tea MN,Ebert BW,Bardy C,van den Hurk M,Bonder CS,Manavis J,Ensbey KS,Oksdath Mansilla M,Scheer KG,Perrin SL,Ormsby RJ,Poonnoose S,Koszyca B,Pitson SM,Day BW,Gomez GA,Brown MP
Sun Apr 17 00:00:00 EDT 2022
Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation.
Scientific reports
Okarmus J,Bogetofte H,Schmidt SI,Ryding M,García-López S,Ryan BJ,Martínez-Serrano A,Hyttel P,Meyer M
Wed Jun 24 00:00:00 EDT 2020
Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model.
eLife
Lee H,Lee HY,Lee BE,Gerovska D,Park SY,Zaehres H,Araúzo-Bravo MJ,Kim JI,Ha Y,Schöler HR,Kim JB
100-45 was used in Cell Culture to investigate the use of induced motor neurons to treat spinal cord injury.
Tue Jun 23 00:00:00 EDT 2020
OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome.
Cell stem cell
Xu R,Brawner AT,Li S,Liu JJ,Kim H,Xue H,Pang ZP,Kim WY,Hart RP,Liu Y,Jiang P
100-45 was used in Tissue/organ culture to conclude that altered OLIG2 expression may underlie neurodevelopmental abnormalities and cognitive defects in DS patients.
Thu Jun 06 00:00:00 EDT 2019
PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.
The Journal of clinical investigation
Li Y,Hu Q,Li C,Liang K,Xiang Y,Hsiao H,Nguyen TK,Park PK,Egranov SD,Ambati CR,Putluri N,Hawke DH,Han L,Hung MC,Danesh FR,Yang L,Lin C
Fri Mar 01 00:00:00 EST 2019
Pigment epithelium-derived factor peptide promotes limbal stem cell proliferation through hedgehog pathway.
Journal of cellular and molecular medicine
Fan NW,Ho TC,Wu CW,Tsao YP
Mon Jul 01 00:00:00 EDT 2019
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Nature communications
Zhao Y,Sun X,Hu D,Prosdocimo DA,Hoppel C,Jain MK,Ramachandran R,Qi X
Tue Mar 26 00:00:00 EDT 2019
Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome.
Nature communications
Zhu W,Zhang B,Li M,Mo F,Mi T,Wu Y,Teng Z,Zhou Q,Li W,Hu B
Mon Feb 25 00:00:00 EST 2019
EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.
Cancer cell
Zingg D,Debbache J,Peña-Hernández R,Antunes AT,Schaefer SM,Cheng PF,Zimmerli D,Haeusel J,Calçada RR,Tuncer E,Zhang Y,Bossart R,Wong KK,Basler K,Dummer R,Santoro R,Levesque MP,Sommer L
Mon Jul 09 00:00:00 EDT 2018
Generation of human brain region-specific organoids using a miniaturized spinning bioreactor.
Nature protocols
Qian X,Jacob F,Song MM,Nguyen HN,Song H,Ming GL
Thu Mar 01 00:00:00 EST 2018
TNF inhibits catecholamine production from induced sympathetic neuron-like cells in rheumatoid arthritis and osteoarthritis in vitro.
Scientific reports
Herrmann M,Anders S,Straub RH,Jenei-Lanzl Z
Mon Jun 25 00:00:00 EDT 2018
A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs.
Stem cell reports
Wu M,Zhang D,Bi C,Mi T,Zhu W,Xia L,Teng Z,Hu B,Wu Y
Tue Sep 11 00:00:00 EDT 2018
Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases.
Experimental & molecular medicine
Bansal R,Nakagawa S,Yazdani S,van Baarlen J,Venkatesh A,Koh AP,Song WM,Goossens N,Watanabe H,Beasley MB,Powell CA,Storm G,Kaminski N,van Goor H,Friedman SL,Hoshida Y,Prakash J
Fri Nov 17 00:00:00 EST 2017
Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.
Stem cell reports
Muratore CR,Zhou C,Liao M,Fernandez MA,Taylor WM,Lagomarsino VN,Pearse RV,Rice HC,Negri JM,He A,Srikanth P,Callahan DG,Shin T,Zhou M,Bennett DA,Noggle S,Love JC,Selkoe DJ,Young-Pearse TL
Tue Dec 12 00:00:00 EST 2017
Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors.
Blood
Dagklis A,Demeyer S,De Bie J,Radaelli E,Pauwels D,Degryse S,Gielen O,Vicente C,Vandepoel R,Geerdens E,Uyttebroeck A,Boeckx N,de Bock CE,Cools J
Thu Dec 08 00:00:00 EST 2016
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.
Nature communications
Guo X,Sun X,Hu D,Wang YJ,Fujioka H,Vyas R,Chakrapani S,Joshi AU,Luo Y,Mochly-Rosen D,Qi X
Fri Aug 26 00:00:00 EDT 2016
Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion.
Scientific reports
Tian C,Li Y,Huang Y,Wang Y,Chen D,Liu J,Deng X,Sun L,Anderson K,Qi X,Li Y,Lee Mosley R,Chen X,Huang J,Zheng JC
Thu Jul 30 00:00:00 EDT 2015
Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature.
Scientific reports
Ng TK,Yung JS,Choy KW,Cao D,Leung CK,Cheung HS,Pang CP
Mon Nov 09 00:00:00 EST 2015
A High-content screen identifies compounds promoting the neuronal differentiation and the midbrain dopamine neuron specification of human neural progenitor cells.
Scientific reports
Rhim JH,Luo X,Xu X,Gao D,Zhou T,Li F,Qin L,Wang P,Xia X,Wong ST
Fri Nov 06 00:00:00 EST 2015
A global transcriptome analysis reveals molecular hallmarks of neural stem cell death, survival, and differentiation in response to partial FGF-2 and EGF deprivation.
PloS one
Nieto-Estévez V,Pignatelli J,Araúzo-Bravo MJ,Hurtado-Chong A,Vicario-Abejón C
Tue Jul 02 00:00:00 EDT 2013
Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells.
Stem cells (Dayton, Ohio)
Nefzger CM,Su CT,Fabb SA,Hartley BJ,Beh SJ,Zeng WR,Haynes JM,Pouton CW
Sun Jul 01 00:00:00 EDT 2012
Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells.
Stem cells (Dayton, Ohio)
Mellough CB,Sernagor E,Moreno-Gimeno I,Steel DH,Lako M
Sun Apr 01 00:00:00 EDT 2012
Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans.
The Journal of clinical investigation
Ngan ES,Garcia-Barceló MM,Yip BH,Poon HC,Lau ST,Kwok CK,Sat E,Sham MH,Wong KK,Wainwright BJ,Cherny SS,Hui CC,Sham PC,Lui VC,Tam PK
Thu Sep 01 00:00:00 EDT 2011
Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells.
Stem cells (Dayton, Ohio)
Nefzger CM,Haynes JM,Pouton CW
Wed Jun 01 00:00:00 EDT 2011
