Product References
Articular Cartilage Chondroprogenitors: Isolation and Directed Differentiation.
Methods in molecular biology (Clifton, N.J.)
Khan IM,McKenna J,Zhang Y
100-21C was used in In vitro experiments to describe the optimal conditions and factors required to differentiate these progenitor cells to produce hyaline articular cartilage.
Mon Nov 14 00:00:00 EST 2022
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells.
Nature biotechnology
Tao Y,Li X,Dong Q,Kong L,Petersen AJ,Yan Y,Xu K,Zima S,Li Y,Schmidt DK,Ayala M,Mathivanan S,Sousa AMM,Chang Q,Zhang SC
100-21C was used in Cell Culture to develop a method to generate 40-60% human LC-NE neurons from human pluripotent stem cells.
Thu Nov 16 00:00:00 EST 2023
Real-time thiol detection in iPSC-derived neuron cultures using SemKur-IM, a novel fluorescent dithio probe.
SLAS discovery : advancing life sciences R & D
Alvarez R,Kurfis J,Hendrickson M,Sem DS
100-21C was used in Cell Culture to demonstrate the utility of SemKur-IM in the detection of thiol levels in live cells in response to chemical exposures, such as from drugs that return the cell to a healthier reduced state.
Mon Nov 20 00:00:00 EST 2023
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
Nature neuroscience
Dräger NM,Sattler SM,Huang CT,Teter OM,Leng K,Hashemi SH,Hong J,Aviles G,Clelland CD,Zhan L,Udeochu JC,Kodama L,Singleton AB,Nalls MA,Ichida J,Ward ME,Faghri F,Gan L,Kampmann M
100-21C was used in In vitro experiments to present a screening platform to systematically elucidate functional consequences of genetic perturbations in human induced pluripotent stem cell-derived microglia.
Thu Sep 01 00:00:00 EDT 2022
Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs.
Frontiers in endocrinology
Goodnough LH,Ambrosi TH,Steininger HM,Butler MGK,Hoover MY,Choo H,Van Rysselberghe NL,Bellino MJ,Bishop JA,Gardner MJ,Chan CKF
100-21C was used in Cell Culture to study species-specific differences in Non-Steroidal Anti-Inflammatory Drug (NSAID) sensitivity during fracture healing.
Tue Sep 13 00:00:00 EDT 2022
Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs.
Frontiers in endocrinology
Goodnough LH,Ambrosi TH,Steininger HM,Butler MGK,Hoover MY,Choo H,Van Rysselberghe NL,Bellino MJ,Bishop JA,Gardner MJ,Chan CKF
100-21C was used in Cell Culture to study species-specific differences in Non-Steroidal Anti-Inflammatory Drug (NSAID) sensitivity during fracture healing.
Tue Sep 13 00:00:00 EDT 2022
Upregulation of dual-specificity phosphatase-26 is required for transforming growth factor β1(TGFβ1)-induced Epithelial-mesenchymal transition in A549 and PANC1 cells.
Molecular biology reports
Guler S,Zik B,Yalcin A
100-21C was used in Sample Preparation (PCR) to investigate molecular regulation of EMT in cancer.
Tue Nov 01 00:00:00 EDT 2022
Verteporfin ameliorates fibrotic aspects of Dupuytren's disease nodular fibroblasts irrespective the activation state of the cells.
Scientific reports
Puerta Cavanzo N,Riesmeijer SA,Holt-Kedde IL,Werker PMN,Piersma B,Olinga P,Bank RA
100-21C was used in Cell Culture to conclude that verteporfin (VP) has strong anti-fibrotic properties: it is able to halt the differentiation of fibroblasts into myofibroblasts, and is also able to reverse the activation status of fibroblasts.
Wed Aug 17 00:00:00 EDT 2022
Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction.
Scientific reports
Zywitza V,Rusha E,Shaposhnikov D,Ruiz-Orera J,Telugu N,Rishko V,Hayashi M,Michel G,Wittler L,Stejskal J,Holtze S,Göritz F,Hermes R,Wang J,Izsvák Z,Colleoni S,Lazzari G,Galli C,Hildebrandt TB,Hayashi K,Diecke S,Drukker M
100-21C was used in Cell Culture to study rescuing the northern white rhinoceros (NWR) functionally extinct species using induced pluripotent stem cells (iPSCs) to generate gametes and subsequently embryos in vitro.
Tue Mar 08 00:00:00 EST 2022
β-Klotho Promotes the Development of Intrauterine Adhesions via the PI3K/AKT Signaling Pathway.
International journal of molecular sciences
Guo Z,Wang Y,Wen X,Xu X,Yan L
100-21C was used in Cell Culture to show that KLB protein is highly expressed in the ESCs of patients with IUA and can enhance stromal cell proliferation and cell fibrosis by activating the PI3K/AKT pathway, thus promoting the development of IUA.
Sun Sep 25 00:00:00 EDT 2022
Neuroinflammation in Primary Cultures of the Rat Spinal Dorsal Horn Is Attenuated in the Presence of Adipose Tissue-Derived Medicinal Signalling Cells (AdMSCs) in a Co-cultivation Model.
Molecular neurobiology
Leisengang S,Heilen LB,Klymiuk MC,Nürnberger F,Ott D,Wolf-Hofmann K,Gerstberger R,Rummel C,Schmidt MJ,Arnhold S,Roth J
100-21C was used in Sample Preparation to present a novel co-cultivation system of AdMSCs with neuroglial primary cultures of the SDH to investigate immunomodulatory effects of AdMSCs at a cellular level.
Sat Jan 01 00:00:00 EST 2022
Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity.
Viruses
Cruz-Lorenzo E,Ramirez NP,Lee J,Pandhe S,Wang L,Hernandez-Doria J,Spivak AM,Planelles V,Petersen T,Jain MK,Martinez ED,D'Orso I
100-21C was used in Cell Culture to suggest that manipulation of redox-sensitive pathways could be exploited to alter the course of HIV-1 latency, thus rendering host cells responsive to help achieve a sterilizing cure.
Tue Oct 18 00:00:00 EDT 2022
Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5.
Nature cancer
Sun Y,Yan K,Wang Y,Xu C,Wang D,Zhou W,Guo S,Han Y,Tang L,Shao Y,Shan S,Zhang QC,Tang Y,Zhang L,Xi Q
100-21C was used in In vitro experiments to show how BMP signaling impacts diffuse intrinsic pontine glioma (DIPG) and identifies the potent antitumor efficacy of Dacinostat for DIPG.
Thu Sep 01 00:00:00 EDT 2022
Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia.
Frontiers in immunology
Wallach T,Raden M,Hinkelmann L,Brehm M,Rabsch D,Weidling H,Krüger C,Kettenmann H,Backofen R,Lehnardt S
100-21C was used in In vitro experiments to determine TLR7 and TLR8 as key sensors of SARS-CoV-2-derived ssRNAs and may deepen our understanding of the mechanisms how this virus triggers, but also modulates an inflammatory response through innate immune signaling.
Tue Jan 31 00:00:00 EST 2023
P97/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration.
Brain communications
Wang F,Li S,Wang TY,Lopez GA,Antoshechkin I,Chou TF
100-21C was used in Cell Culture to find that two p97 inhibitors, CB-5083 and NMS-873, restore some dysregulated protein levels.
Tue Aug 30 00:00:00 EDT 2022
Gene therapy of Csf2ra deficiency in mouse fetal monocyte precursors restores alveolar macrophage development and function.
JCI insight
Li F,Okreglicka KM,Piattini F,Pohlmeier LM,Schneider C,Kopf M
100-21C was used in Cell Culture to study how fetal liver monocytes cultured with GM-CSF (CSF2-cFLiMo) rapidly differentiated into a long-lived, homogeneous alveolar macrophage-like population in vitro and rovide a platform for generation of immature alveolar macrophage-like precursors amenable for genetic manipulation, which will be useful to dissect alveolar macrophage development and function and for pulmonary transplantation therapy.
Fri Apr 08 00:00:00 EDT 2022
Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition.
Inflammation and regeneration
Kobayashi M,Fujiwara K,Takahashi K,Yoshioka Y,Ochiya T,Podyma-Inoue KA,Watabe T
100-21C was used in Cell Culture to conclude that EVs released from oral cancer cells that underwent TGF-β-induced EMT target endothelial cells to induce vascular destabilization.
Sun Sep 04 00:00:00 EDT 2022
Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.
Immunity
Yan Y,Ramanan D,Rozenberg M,McGovern K,Rastelli D,Vijaykumar B,Yaghi O,Voisin T,Mosaheb M,Chiu I,Itzkovitz S,Rao M,Mathis D,Benoist C
Tue Mar 09 00:00:00 EST 2021
Cold exposure protects from neuroinflammation through immunologic reprogramming.
Cell metabolism
Spiljar M,Steinbach K,Rigo D,Suárez-Zamorano N,Wagner I,Hadadi N,Vincenti I,Page N,Klimek B,Rochat MA,Kreutzfeldt M,Chevalier C,Stojanović O,Bejuy O,Colin D,Mack M,Cansever D,Greter M,Merkler D,Trajkovski M
Tue Nov 02 00:00:00 EDT 2021
BMI1 maintains the Treg epigenomic landscape to prevent inflammatory bowel disease.
The Journal of clinical investigation
Gonzalez MM,Bamidele AO,Svingen PA,Sagstetter MR,Smyrk TC,Gaballa JM,Hamdan FH,Kosinsky RL,Gibbons HR,Sun Z,Ye Z,Nair A,Ramos GP,Braga Neto MB,Wixom AQ,Mathison AJ,Johnsen SA,Urrutia R,Faubion WA
Tue Jun 15 00:00:00 EDT 2021
Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity.
The Journal of experimental medicine
Xiao Y,Qureischi M,Dietz L,Vaeth M,Vallabhapurapu SD,Klein-Hessling S,Klein M,Liang C,König A,Serfling E,Mottok A,Bopp T,Rosenwald A,Buttmann M,Berberich I,Beilhack A,Berberich-Siebelt F
Mon Jan 04 00:00:00 EST 2021
Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation.
The Journal of experimental medicine
Györfi AH,Matei AE,Fuchs M,Liang C,Rigau AR,Hong X,Zhu H,Luber M,Bergmann C,Dees C,Ludolph I,Horch RE,Distler O,Wang J,Bengsch B,Schett G,Kunz M,Distler JHW
Mon Sep 06 00:00:00 EDT 2021
Arkadia-SKI/SnoN signaling differentially regulates TGF-β-induced iTreg and Th17 cell differentiation.
The Journal of experimental medicine
Xu H,Wu L,Nguyen HH,Mesa KR,Raghavan V,Episkopou V,Littman DR
Mon Nov 01 00:00:00 EDT 2021
Modeling genetic epileptic encephalopathies using brain organoids.
EMBO molecular medicine
Steinberg DJ,Repudi S,Saleem A,Kustanovich I,Viukov S,Abudiab B,Banne E,Mahajnah M,Hanna JH,Stern S,Carlen PL,Aqeilan RI
Mon Aug 09 00:00:00 EDT 2021
The secretome mouse provides a genetic platform to delineate tissue-specific in vivo secretion.
Proceedings of the National Academy of Sciences of the United States of America
Liu J,Jang JY,Pirooznia M,Liu S,Finkel T
Tue Jan 19 00:00:00 EST 2021
miR-99a regulates CD4+ T cell differentiation and attenuates experimental autoimmune encephalomyelitis by mTOR-mediated glycolysis.
Molecular therapy. Nucleic acids
Gu Y,Zhou H,Yu H,Yang W,Wang B,Qian F,Cheng Y,He S,Zhao X,Zhu L,Zhang Y,Jin M,Lu E
Fri Dec 03 00:00:00 EST 2021
The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling.
Oncogene
Papoutsoglou P,Rodrigues-Junior DM,Morén A,Bergman A,Pontén F,Coulouarn C,Caja L,Heldin CH,Moustakas A
Sat May 01 00:00:00 EDT 2021
Pretreatment with valproic acid alleviates pulmonary fibrosis through epithelial-mesenchymal transition inhibition in vitro and in vivo.
Laboratory investigation; a journal of technical methods and pathology
Chen L,Alam A,Pac-Soo A,Chen Q,Shang Y,Zhao H,Yao S,Ma D
Wed Sep 01 00:00:00 EDT 2021
Development of an Optimized Culture System for Generating Mouse Alveolar Macrophage-like Cells.
Journal of immunology (Baltimore, Md. : 1950)
Luo M,Lai W,He Z,Wu L
Wed Sep 15 00:00:00 EDT 2021
Proinflammatory Features of Stem Cell-like Memory T Cells from Human Patients with Rheumatoid Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Lee YJ,Park EH,Park JW,Jung KC,Lee EB
Thu Jul 15 00:00:00 EDT 2021
A dual role of YAP in driving TGFβ-mediated endothelial-to-mesenchymal transition.
Journal of cell science
Savorani C,Malinverno M,Seccia R,Maderna C,Giannotta M,Terreran L,Mastrapasqua E,Campaner S,Dejana E,Giampietro C
100-21C was used in In vitro experiments to study a dual role of YAP in driving TGFβ-mediated endothelial-to-mesenchymal transition.
Sun Aug 01 00:00:00 EDT 2021
ALK1 regulates the internalization of endoglin and the type III TGF-β receptor.
Molecular biology of the cell
Tazat K,Pomeraniec-Abudy L,Hector-Greene M,Szilágyi SS,Sharma S,Cai EM,Corona AL,Ehrlich M,Blobe GC,Henis YI
100-21C was used in In vitro experiments to investigate the effects of ALK1 on the regulation of endocytosis of the TGF-β receptors.
Thu Apr 01 00:00:00 EDT 2021
Glycyrrhizic acid restrains airway inflammation and remodeling in asthma via the TGF-β1/Smad signaling pathway.
Experimental and therapeutic medicine
Yao Z,Fu Y
100-21C was used in In vivo experiments to study the function and potential molecular mechanism of glycyrrhizic acid (GA) for modulating the transforming growth factor-β1 (TGF-β1)/Smad signaling pathway in asthma-associated airway inflammation and remodeling.
Sat May 01 00:00:00 EDT 2021
Concomitant attenuation of HMGCR expression and activity enhances the growth inhibitory effect of atorvastatin on TGF-β-treated epithelial cancer cells.
Scientific reports
Warita K,Ishikawa T,Sugiura A,Tashiro J,Shimakura H,Hosaka YZ,Ohta KI,Warita T,Oltvai ZN
Thu Jun 17 00:00:00 EDT 2021
Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia.
Nature communications
Bassil R,Shields K,Granger K,Zein I,Ng S,Chih B
Wed Sep 01 00:00:00 EDT 2021
Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties.
NPJ Regenerative medicine
Brown WE,Huang BJ,Hu JC,Athanasiou KA
Fri Aug 06 00:00:00 EDT 2021
Protective effect of dimethyl itaconate against fibroblast-myofibroblast differentiation during pulmonary fibrosis by inhibiting TXNIP.
Journal of cellular physiology
Han YY,Gu X,Yang CY,Ji HM,Lan YJ,Bi YQ,Si R,Qu J,Cheng MH,Gao J
100-21C was used in In vitro experiments to provide new therapeutic targets and treatment approaches for PF.
Mon Nov 01 00:00:00 EDT 2021
Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening.
Scientific reports
Boussaad I,Cruciani G,Bolognin S,Antony P,Dording CM,Kwon YJ,Heutink P,Fava E,Schwamborn JC,Krüger R
Thu Jan 14 00:00:00 EST 2021
Nerve Growth Factor (NGF) modulates in vitro induced myofibroblasts by highlighting a differential protein signature.
Scientific reports
Esposito G,Balzamino BO,Stigliano E,Biamonte F,Urbani A,Micera A
Mon Jan 18 00:00:00 EST 2021
Regulation of TGFβ Signalling by TRPV4 in Chondrocytes.
Cells
Woods S,Humphreys PA,Bates N,Richardson SA,Kuba SY,Brooks IR,Cain SA,Kimber SJ
100-21C was used in Cell Culture to study how TRPV4 and TGFβ signals are integrated to show that TRPV4 modulation of TGFβ signalling represents an important pathway linking mechanical signalling to tissue development and homeostasis.
Wed Mar 24 00:00:00 EDT 2021
Regulation of TGFβ Signalling by TRPV4 in Chondrocytes.
Cells
Woods S,Humphreys PA,Bates N,Richardson SA,Kuba SY,Brooks IR,Cain SA,Kimber SJ
100-21C was used in Cell Culture to study how TRPV4 and TGFβ signals are integrated to show that TRPV4 modulation of TGFβ signalling represents an important pathway linking mechanical signalling to tissue development and homeostasis.
Wed Mar 24 00:00:00 EDT 2021
Novel lipophosphonoxin-loaded polycaprolactone electrospun nanofiber dressing reduces Staphylococcus aureus induced wound infection in mice.
Scientific reports
Do Pham DD,Jenčová V,Kaňuchová M,Bayram J,Grossová I,Šuca H,Urban L,Havlíčková K,Novotný V,Mikeš P,Mojr V,Asatiani N,Koš¿áková EK,Maixnerová M,Vlková A,Vítovská D,Šanderová H,Nemec A,Krásný L,Zajíček R,Lukáš D,Rejman D,Gál P
Fri Sep 03 00:00:00 EDT 2021
Novel lipophosphonoxin-loaded polycaprolactone electrospun nanofiber dressing reduces Staphylococcus aureus induced wound infection in mice.
Scientific reports
Do Pham DD,Jenčová V,Kaňuchová M,Bayram J,Grossová I,Šuca H,Urban L,Havlíčková K,Novotný V,Mikeš P,Mojr V,Asatiani N,Koš¿áková EK,Maixnerová M,Vlková A,Vítovská D,Šanderová H,Nemec A,Krásný L,Zajíček R,Lukáš D,Rejman D,Gál P
Fri Sep 03 00:00:00 EDT 2021
Novel lipophosphonoxin-loaded polycaprolactone electrospun nanofiber dressing reduces Staphylococcus aureus induced wound infection in mice.
Scientific reports
Do Pham DD,Jenčová V,Kaňuchová M,Bayram J,Grossová I,Šuca H,Urban L,Havlíčková K,Novotný V,Mikeš P,Mojr V,Asatiani N,Koš¿áková EK,Maixnerová M,Vlková A,Vítovská D,Šanderová H,Nemec A,Krásný L,Zajíček R,Lukáš D,Rejman D,Gál P
Fri Sep 03 00:00:00 EDT 2021
Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis.
Scientific reports
Noda K,Dufner B,Ito H,Yoshida K,Balboni G,Straub RH
Wed Sep 15 00:00:00 EDT 2021
Trajectory modeling of endothelial-to-mesenchymal transition reveals galectin-3 as a mediator in pulmonary fibrosis.
Cell death & disease
Jia W,Wang Z,Gao C,Wu J,Wu Q
Fri Mar 26 00:00:00 EDT 2021
Identification of hepatic fibrosis inhibitors through morphometry analysis of a hepatic multicellular spheroids model.
Scientific reports
Song Y,Kim S,Heo J,Shum D,Lee SY,Lee M,Kim AR,Seo HR
Tue May 25 00:00:00 EDT 2021
Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts.
International journal of cardiology. Heart & vasculature
Magaye RR,Savira F,Xiong X,Huynh K,Meikle PJ,Reid C,Flynn BL,Kaye D,Liew D,Wang BH
100-21C was used in Cell Culture to study the effects of collagen synthesis in primary rat neonatal cardiac fibroblasts (NCFs).
Sun Aug 01 00:00:00 EDT 2021
Pre-emptive pharmacological inhibition of fatty acid-binding protein 4 attenuates kidney fibrosis by reprogramming tubular lipid metabolism.
Cell death & disease
Chen Y,Dai Y,Song K,Huang Y,Zhang L,Zhang C,Yan Q,Gao H
Thu Jun 03 00:00:00 EDT 2021
Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer.
Cell
Katzenelenbogen Y,Sheban F,Yalin A,Yofe I,Svetlichnyy D,Jaitin DA,Bornstein C,Moshe A,Keren-Shaul H,Cohen M,Wang SY,Li B,David E,Salame TM,Weiner A,Amit I
Thu Aug 20 00:00:00 EDT 2020
High-Dimensional T Helper Cell Profiling Reveals a Broad Diversity of Stably Committed Effector States and Uncovers Interlineage Relationships.
Immunity
Tortola L,Jacobs A,Pohlmeier L,Obermair FJ,Ampenberger F,Bodenmiller B,Kopf M
Tue Sep 15 00:00:00 EDT 2020
Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-β pathway.
Signal transduction and targeted therapy
Yang X,Ma L,Wei R,Ye T,Zhou J,Wen M,Men R,Aqeilan RI,Peng Y,Yang L
Fri Jun 05 00:00:00 EDT 2020
Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-β pathway.
Signal transduction and targeted therapy
Yang X,Ma L,Wei R,Ye T,Zhou J,Wen M,Men R,Aqeilan RI,Peng Y,Yang L
Fri Jun 05 00:00:00 EDT 2020
Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN.
Blood
Gleitz HFE,Dugourd AJF,Leimkühler NB,Snoeren IAM,Fuchs SNR,Menzel S,Ziegler S,Kröger N,Triviai I,Büsche G,Kreipe H,Banjanin B,Pritchard JE,Hoogenboezem R,Bindels EM,Schumacher N,Rose-John S,Elf S,Saez-Rodriguez J,Kramann R,Schneider RK
Thu Oct 29 00:00:00 EDT 2020
Bone marrow-derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis.
Blood
Xiao Y,van Halteren AGS,Lei X,Borst J,Steenwijk E,de Wit T,Grabowska J,Voogd R,Kemps P,Picarsic J,van den Bos C,Borst J
Thu Nov 05 00:00:00 EST 2020
TGF-β-induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis.
The Journal of clinical investigation
Dees C,Pötter S,Zhang Y,Bergmann C,Zhou X,Luber M,Wohlfahrt T,Karouzakis E,Ramming A,Gelse K,Yoshimura A,Jaenisch R,Distler O,Schett G,Distler JH
Fri May 01 00:00:00 EDT 2020
Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin.
The Journal of clinical investigation
Andreev D,Liu M,Weidner D,Kachler K,Faas M,Grüneboom A,Schlötzer-Schrehardt U,Muñoz LE,Steffen U,Grötsch B,Killy B,Krönke G,Luebke AM,Niemeier A,Wehrhan F,Lang R,Schett G,Bozec A
Tue Sep 01 00:00:00 EDT 2020
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments.
The Journal of clinical investigation
Matthias J,Heink S,Picard F,Zeiträg J,Kolz A,Chao YY,Soll D,de Almeida GP,Glasmacher E,Jacobsen ID,Riedel T,Peters A,Floess S,Huehn J,Baumjohann D,Huber M,Korn T,Zielinski CE
Tue Sep 01 00:00:00 EDT 2020
Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36.
Neuron
McEachin ZT,Gendron TF,Raj N,García-Murias M,Banerjee A,Purcell RH,Ward PJ,Todd TW,Merritt-Garza ME,Jansen-West K,Hales CM,García-Sobrino T,Quintáns B,Holler CJ,Taylor G,San Millán B,Teijeira S,Yamashita T,Ohkubo R,Boulis NM,Xu C,Wen Z,Streichenberger N,Fogel BL,Kukar T,Abe K,Dickson DW,Arias M,Glass JD,Jiang J,Tansey MG,Sobrido MJ,Petrucelli L,Rossoll W,Bassell GJ
Wed Jul 22 00:00:00 EDT 2020
TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status.
Autophagy
Liang C,Xu J,Meng Q,Zhang B,Liu J,Hua J,Zhang Y,Shi S,Yu X
100-21C was used in Cell Culture to conclude that TGFB1-induced autophagy contributed to the different patterns of pancreatic ductal adenocarcinoma (PDAC) progression.
Sun Mar 01 00:00:00 EST 2020
Geriatric fragility fractures are associated with a human skeletal stem cell defect.
Aging cell
Ambrosi TH,Goodnough LH,Steininger HM,Hoover MY,Kim E,Koepke LS,Marecic O,Zhao L,Seita J,Bishop JA,Gardner MJ,Chan CKF
Wed Jul 01 00:00:00 EDT 2020
MSCs rescue impaired wound healing in a murine LAD1 model by adaptive responses to low TGF-β1 levels.
EMBO reports
Jiang D,Singh K,Muschhammer J,Schatz S,Sindrilaru A,Makrantonaki E,Qi Y,Wlaschek M,Scharffetter-Kochanek K
Fri Apr 03 00:00:00 EDT 2020
CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion.
The Journal of cell biology
Farrugia AJ,Rodríguez J,Orgaz JL,Lucas M,Sanz-Moreno V,Calvo F
Mon Sep 07 00:00:00 EDT 2020
microRNA-132 is overexpressed in glia in temporal lobe epilepsy and reduces the expression of pro-epileptogenic factors in human cultured astrocytes.
Glia
Korotkov A,Broekaart DWM,Banchaewa L,Pustjens B,van Scheppingen J,Anink JJ,Baayen JC,Idema S,Gorter JA,van Vliet EA,Aronica E
Wed Jan 01 00:00:00 EST 2020
Human osteoarthritis cartilage-derived stromal cells activate joint degeneration through TGF-beta lateral signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Liu W,Feng M,Jayasuriya CT,Peng H,Zhang L,Guan Y,Froehlich JA,Terek RM,Chen Q
Tue Dec 01 00:00:00 EST 2020
IQGAP1 restrains T-cell cosignaling mediated by OX40.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Okuyama Y,Nagashima H,Ushio-Fukai M,Croft M,Ishii N,So T
Wed Jan 01 00:00:00 EST 2020
Analysis of proximal ALOX5 promoter binding proteins by quantitative proteomics.
The FEBS journal
Schlag K,Steinhilber D,Karas M,Sorg BL
Thu Oct 01 00:00:00 EDT 2020
TGF-β and IL-15 Synergize through MAPK Pathways to Drive the Conversion of Human NK Cells to an Innate Lymphoid Cell 1-like Phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Hawke LG,Mitchell BZ,Ormiston ML
Mon Jun 15 00:00:00 EDT 2020
MeCP2-421-mediated RPE epithelial-mesenchymal transition and its relevance to the pathogenesis of proliferative vitreoretinopathy.
Journal of cellular and molecular medicine
Li X,Li X,He S,Zhao M
Sat Aug 01 00:00:00 EDT 2020
Novel long non-coding RNA LINC02323 promotes epithelial-mesenchymal transition and metastasis via sponging miR-1343-3p in lung adenocarcinoma.
Thoracic cancer
Zhang X,Du L,Han J,Li X,Wang H,Zheng G,Wang Y,Yang Y,Hu Y,Wang C
Tue Sep 01 00:00:00 EDT 2020
Involvement of the TGF-β1 pathway in caveolin-1-associated regulation of head and neck tumor cell metastasis.
Oncology letters
Sun J,Lu Y,Yu C,Xu T,Nie G,Miao B,Zhang X
100-21C was used in Cell Culture to indicate that Cav-1 inhibits cell metastasis in HNSCC, suggesting the involvement of the TGF-β signaling pathway.
Sat Feb 01 00:00:00 EST 2020
A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons.
Nature communications
Sybirna A,Tang WWC,Pierson Smela M,Dietmann S,Gruhn WH,Brosh R,Surani MA
Mon Mar 09 00:00:00 EDT 2020
Growth factors-based beneficial effects of platelet lysate on umbilical cord-derived stem cells and their synergistic use in osteoarthritis treatment.
Cell death & disease
Yan L,Zhou L,Yan B,Zhang L,Du W,Liu F,Yuan Q,Tong P,Shan L,Efferth T
Wed Oct 14 00:00:00 EDT 2020
MICAL2 is essential for myogenic lineage commitment.
Cell death & disease
Giarratana N,Conti F,La Rovere R,Gijsbers R,Carai P,Duelen R,Vervliet T,Bultynck G,Ronzoni F,Piciotti R,Costamagna D,Fulle S,Barravecchia I,Angeloni D,Torrente Y,Sampaolesi M
Tue Aug 18 00:00:00 EDT 2020
Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina.
Nature communications
Park TS,Zimmerlin L,Evans-Moses R,Thomas J,Huo JS,Kanherkar R,He A,Ruzgar N,Grebe R,Bhutto I,Barbato M,Koldobskiy MA,Lutty G,Zambidis ET
Thu Mar 05 00:00:00 EST 2020
Repeated intramuscular transplantations of hUCB-MSCs improves motor function and survival in the SOD1 G93A mice through activation of AMPK.
Scientific reports
Kook MG,Lee S,Shin N,Kong D,Kim DH,Kim MS,Kang HK,Choi SW,Kang KS
Fri Jan 31 00:00:00 EST 2020
Long-term administration of recombinant canstatin prevents adverse cardiac remodeling after myocardial infarction.
Scientific reports
Sugiyama A,Ito R,Okada M,Yamawaki H
Thu Jul 30 00:00:00 EDT 2020
Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis.
Cell death & disease
Chen Y,Yan Q,Lv M,Song K,Dai Y,Huang Y,Zhang L,Zhang C,Gao H
Fri Nov 20 00:00:00 EST 2020
Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma.
Nature communications
Tao W,Chu C,Zhou W,Huang Z,Zhai K,Fang X,Huang Q,Zhang A,Wang X,Yu X,Huang H,Wu Q,Sloan AE,Yu JS,Li X,Stark GR,Rich JN,Bao S
Mon Jun 15 00:00:00 EDT 2020
Autofluorescence-based sorting removes senescent cells from mesenchymal stromal cell cultures.
Scientific reports
Bertolo A,Guerrero J,Stoyanov J
Thu Nov 05 00:00:00 EST 2020
The Antiproliferative and Antifibrotic Effects of Cisplatin on Primary Human Vocal Fold Fibroblasts.
ORL; journal for oto-rhino-laryngology and its related specialties
Xu H,Wang Q,Fan GK
100-21C was used in In vitro experiments to show that cisplatin decreased the relative viability of HVFFs, and Western blots revealed elevation of the apoptosis-related protein caspase-3 in HVFFs.
Tue Mar 30 00:00:00 EDT 2021
A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior.
Nature communications
Schiano Lomoriello I,Giangreco G,Iavarone C,Tordonato C,Caldieri G,Serio G,Confalonieri S,Freddi S,Bianchi F,Pirroni S,Bertalot G,Viale G,Disalvatore D,Tosoni D,Malabarba MG,Disanza A,Scita G,Pece S,Pilcher BK,Vecchi M,Sigismund S,Di Fiore PP
Mon Jun 15 00:00:00 EDT 2020
Human Adipocyte Conditioned Medium Promotes In Vitro Fibroblast Conversion to Myofibroblasts.
Scientific reports
El-Hattab MY,Nagumo Y,Gourronc FA,Klingelhutz AJ,Ankrum JA,Sander EA
Wed Jun 24 00:00:00 EDT 2020
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.
Cell death & disease
Jia Z,Zhang Y,Yan A,Wang M,Han Q,Wang K,Wang J,Qiao C,Pan Z,Chen C,Hu D,Ding X
Thu Aug 20 00:00:00 EDT 2020
Recapitulation of Neural Crest Specification and EMT via Induction from Neural Plate Border-like Cells.
Stem cell reports
Kobayashi GS,Musso CM,Moreira DP,Pontillo-Guimarães G,Hsia GSP,Caires-Júnior LC,Goulart E,Passos-Bueno MR
Tue Sep 08 00:00:00 EDT 2020
Identification of candidate genetic variants and altered protein expression in neural stem and mature neural cells support altered microtubule function to be an essential component in bipolar disorder.
Translational psychiatry
Truvé K,Parris TZ,Vizlin-Hodzic D,Salmela S,Berger E,Ågren H,Funa K
Mon Nov 09 00:00:00 EST 2020
Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts.
Bio-protocol
Chen IP
100-21C was used in Cell Culture to study efficient differentiation of hiPSCs into osteoclasts using a three-stage protocol which does not require a co-culture system; induces EBs into mesoderm differentiation in a homogenous manner; uses less cytokines for differentiation; requires only a short time for osteoclast maturation and produces sufficient numbers of osteoclasts for subsequent molecular analyses.
Sun Dec 20 00:00:00 EST 2020
Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity.
The Journal of biological chemistry
Nakano N,Sakata N,Katsu Y,Nochise D,Sato E,Takahashi Y,Yamaguchi S,Haga Y,Ikeno S,Motizuki M,Sano K,Yamasaki K,Miyazawa K,Itoh S
Fri Jul 03 00:00:00 EDT 2020
Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity.
The Journal of biological chemistry
Nakano N,Sakata N,Katsu Y,Nochise D,Sato E,Takahashi Y,Yamaguchi S,Haga Y,Ikeno S,Motizuki M,Sano K,Yamasaki K,Miyazawa K,Itoh S
Fri Jul 03 00:00:00 EDT 2020
The neovascularization effect of dedifferentiated fat cells.
Scientific reports
Watanabe H,Goto S,Kato R,Komiyama S,Nagaoka Y,Kazama T,Yamamoto C,Li Y,Konuma N,Hagikura K,Matsumoto T
Mon Jun 08 00:00:00 EDT 2020
Intratubular epithelial-mesenchymal transition and tubular atrophy after kidney injury in mice.
American journal of physiology. Renal physiology
Yamashita N,Kusaba T,Nakata T,Tomita A,Ida T,Watanabe-Uehara N,Ikeda K,Kitani T,Uehara M,Kirita Y,Matoba S,Humphreys BD,Tamagaki K
Thu Oct 01 00:00:00 EDT 2020
3D Scaffold-Based Macrophage Fibroblast Coculture Model Reveals IL-10 Dependence of Wound Resolution Phase.
Advanced biosystems
Ullm F,Riedl P,Machado de Amorim A,Patzschke A,Weiß R,Hauschildt S,Franke K,Anderegg U,Pompe T
Wed Jan 01 00:00:00 EST 2020
Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis.
Cell death discovery
Conforti F,Ridley R,Brereton C,Alzetani A,Johnson B,Marshall BG,Fletcher SV,Ottensmeier CH,Richeldi L,Skipp P,Wang Y,Jones MG,Davies DE
Tue Sep 26 00:00:00 EDT 2023
BCAP31, a cancer/testis antigen-like protein, can act as a probe for non-small-cell lung cancer metastasis.
Scientific reports
Wang J,Jiang D,Li Z,Yang S,Zhou J,Zhang G,Zhang Z,Sun Y,Zhang Z,Li X,Tao L,Shi J,Lu Y,Zheng L,Song C,Yang K
Wed Mar 04 00:00:00 EST 2020
TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking.
Nature communications
Gunderson AJ,Yamazaki T,McCarty K,Fox N,Phillips M,Alice A,Blair T,Whiteford M,O'Brien D,Ahmad R,Kiely MX,Hayman A,Crocenzi T,Gough MJ,Crittenden MR,Young KH
Thu Apr 09 00:00:00 EDT 2020
Macromolecular Crowding as a Tool to Screen Anti-fibrotic Drugs: The Scar-in-a-Jar System Revisited.
Frontiers in medicine
Puerta Cavanzo N,Bigaeva E,Boersema M,Olinga P,Bank RA
100-21C was used in In vitro experiments to test the macromolecular crowding system for rapid deposition of collagen.
Tue Feb 02 00:00:00 EST 2021
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.
Cell
Rojas OL,Pröbstel AK,Porfilio EA,Wang AA,Charabati M,Sun T,Lee DSW,Galicia G,Ramaglia V,Ward LA,Leung LYT,Najafi G,Khaleghi K,Garcillán B,Li A,Besla R,Naouar I,Cao EY,Chiaranunt P,Burrows K,Robinson HG,Allanach JR,Yam J,Luck H,Campbell DJ,Allman D,Brooks DG,Tomura M,Baumann R,Zamvil SS,Bar-Or A,Horwitz MS,Winer DA,Mortha A,Mackay F,Prat A,Osborne LC,Robbins C,Baranzini SE,Gommerman JL
Thu Jan 24 00:00:00 EST 2019
EDA fibronectin-TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis.
The Journal of experimental medicine
Malara A,Gruppi C,Abbonante V,Cattaneo D,De Marco L,Massa M,Iurlo A,Gianelli U,Balduini CL,Tira ME,Muro AF,Chauhan AK,Rosti V,Barosi G,Balduini A
Mon Mar 04 00:00:00 EST 2019
Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer.
The Journal of experimental medicine
Gao Q,Yang Z,Xu S,Li X,Yang X,Jin P,Liu Y,Zhou X,Zhang T,Gong C,Wei X,Liu D,Sun C,Chen G,Hu J,Meng L,Zhou J,Sawada K,Fruscio R,Grunt TW,Wischhusen J,Vargas-Hernández VM,Pothuri B,Coleman RL
Mon Mar 04 00:00:00 EST 2019
Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer.
EMBO molecular medicine
Huang H,Zhang Y,Gallegos V,Sorrelle N,Zaid MM,Toombs J,Du W,Wright S,Hagopian M,Wang Z,Hosein AN,Sathe AA,Xing C,Koay EJ,Driscoll KE,Brekken RA
Thu Nov 07 00:00:00 EST 2019
Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer.
EMBO molecular medicine
Huang H,Zhang Y,Gallegos V,Sorrelle N,Zaid MM,Toombs J,Du W,Wright S,Hagopian M,Wang Z,Hosein AN,Sathe AA,Xing C,Koay EJ,Driscoll KE,Brekken RA
Thu Nov 07 00:00:00 EST 2019
Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis.
Cell death and differentiation
Yao L,Conforti F,Hill C,Bell J,Drawater L,Li J,Liu D,Xiong H,Alzetani A,Chee SJ,Marshall BG,Fletcher SV,Hancock D,Coldwell M,Yuan X,Ottensmeier CH,Downward J,Collins JE,Ewing RM,Richeldi L,Skipp P,Jones MG,Davies DE,Wang Y
Wed May 01 00:00:00 EDT 2019
Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1.
The Journal of pathology
Ashley N,Ouaret D,Bodmer WF
Fri Mar 01 00:00:00 EST 2019
Zyxin-involved actin regulation is essential in the maintenance of vinculin focal adhesion and chondrocyte differentiation status.
Cell proliferation
Li G,Song X,Li R,Sun L,Gong X,Chen C,Yang L
Tue Jan 01 00:00:00 EST 2019
Mesenchymal Stromal Cell-Seeded Biomimetic Scaffolds as a Factory of Soluble RANKL in Rankl-Deficient Osteopetrosis.
Stem cells translational medicine
Menale C,Campodoni E,Palagano E,Mantero S,Erreni M,Inforzato A,Fontana E,Schena F,Van't Hof R,Sandri M,Tampieri A,Villa A,Sobacchi C
Tue Jan 01 00:00:00 EST 2019
Foxm1 is a critical driver of TGF-β-induced EndMT in endothelial cells through Smad2/3 and binds to the Snail promoter.
Journal of cellular physiology
Song S,Zhang R,Cao W,Fang G,Yu Y,Wan Y,Wang C,Li Y,Wang Q
Sat Jun 01 00:00:00 EDT 2019
TGFβ1 and HGF regulate CTGF expression in human atrial fibroblasts and are involved in atrial remodelling in patients with rheumatic heart disease.
Journal of cellular and molecular medicine
Chen JQ,Guo YS,Chen Q,Cheng XL,Xiang GJ,Chen MY,Wu HL,Huang QL,Zhu PL,Zhang JC
Mon Apr 01 00:00:00 EDT 2019
Changes of Metabolic Phenotype of Cardiac Progenitor Cells During Differentiation: Neutral Effect of Stimulation of AMP-Activated Protein Kinase.
Stem cells and development
André E,De Pauw A,Verdoy R,Brusa D,Bouzin C,Timmermans A,Bertrand L,Balligand JL
100-21C was used in Cell Culture to investigate the pharmacological modulation involved in the metabolic shift of cardiac progenitor cells.
Fri Nov 15 00:00:00 EST 2019
Sanguinarine inhibits epithelial-mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma.
Cell death & disease
Su Q,Fan M,Wang J,Ullah A,Ghauri MA,Dai B,Zhan Y,Zhang D,Zhang Y
Mon Dec 09 00:00:00 EST 2019
Ultrasound-induced Cavitation enhances the efficacy of Chemotherapy in a 3D Model of Pancreatic Ductal Adenocarcinoma with its microenvironment.
Scientific reports
Leenhardt R,Camus M,Mestas JL,Jeljeli M,Abou Ali E,Chouzenoux S,Bordacahar B,Nicco C,Batteux F,Lafon C,Prat F
Thu Dec 12 00:00:00 EST 2019
A Novel Toolkit for Characterizing the Mechanical and Electrical Properties of Engineered Neural Tissues.
Biosensors
Robinson M,Valente KP,Willerth SM
100-21C was used in Cell Culture to design and validate a set of robust and non-toxic protocols for directly evaluating the properties of engineered neural tissue.
Mon Apr 01 00:00:00 EDT 2019
The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes.
Nature communications
Luu M,Pautz S,Kohl V,Singh R,Romero R,Lucas S,Hofmann J,Raifer H,Vachharajani N,Carrascosa LC,Lamp B,Nist A,Stiewe T,Shaul Y,Adhikary T,Zaiss MM,Lauth M,Steinhoff U,Visekruna A
Fri Feb 15 00:00:00 EST 2019
Cytokine Selection of MSC Clones with Different Functionality.
Stem cell reports
Selich A,Ha TC,Morgan M,Falk CS,von Kaisenberg C,Schambach A,Rothe M
Tue Aug 13 00:00:00 EDT 2019
IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.
Nature communications
Lückel C,Picard F,Raifer H,Campos Carrascosa L,Guralnik A,Zhang Y,Klein M,Bittner S,Steffen F,Moos S,Marini F,Gloury R,Kurschus FC,Chao YY,Bertrams W,Sexl V,Schmeck B,Bonetti L,Grusdat M,Lohoff M,Zielinski CE,Zipp F,Kallies A,Brenner D,Berger M,Bopp T,Tackenberg B,Huber M
Mon Dec 16 00:00:00 EST 2019
WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.
Nature communications
Jeong WJ,Park JC,Kim WS,Ro EJ,Jeon SH,Lee SK,Park YN,Min DS,Choi KY
Thu Jan 17 00:00:00 EST 2019
TGF-β signaling promotes tube-structure-forming growth in pancreatic duct adenocarcinoma.
Scientific reports
Yamaguchi T,Ikehara S,Akimoto Y,Nakanishi H,Kume M,Yamamoto K,Ohara O,Ikehara Y
Fri Aug 02 00:00:00 EDT 2019
The indole compound MA-35 attenuates tumorigenesis in an inflammation-induced colon cancer model.
Scientific reports
Kanehara K,Ohnuma S,Kanazawa Y,Sato K,Kokubo S,Suzuki H,Karasawa H,Suzuki T,Suzuki C,Naitoh T,Unno M,Abe T
Wed Sep 04 00:00:00 EDT 2019
TAE226, a dual inhibitor of focal adhesion kinase and insulin-like growth factor-I receptor, is effective for Ewing sarcoma.
Cancer medicine
Moritake H,Saito Y,Sawa D,Sameshima N,Yamada A,Kinoshita M,Kamimura S,Konomoto T,Nunoi H
Sun Dec 01 00:00:00 EST 2019
MicroRNA-145-5p regulates fibrotic features of recessive dystrophic epidermolysis bullosa skin fibroblasts.
The British journal of dermatology
Condorelli AG,Logli E,Cianfarani F,Teson M,Diociaiuti A,El Hachem M,Zambruno G,Castiglia D,Odorisio T
100-21C was used in Cell Culture to highlight the profibrotic role of miR-145-5p and its regulatory networks in RDEB, shedding light on novel disease pathomechanisms and targets for future therapeutic approaches.
Fri Nov 01 00:00:00 EDT 2019
Baicalin ameliorates lupus autoimmunity by inhibiting differentiation of Tfh cells and inducing expansion of Tfr cells.
Cell death & disease
Yang J,Yang X,Yang J,Li M
Wed Feb 13 00:00:00 EST 2019
Oncostatin M exerts a protective effect against excessive scarring by counteracting the inductive effect of TGFβ1 on fibrosis markers.
Scientific reports
Huguier V,Giot JP,Simonneau M,Levillain P,Charreau S,Garcia M,Jégou JF,Bodet C,Morel F,Lecron JC,Favot L
Thu Feb 14 00:00:00 EST 2019
PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-β (TGF-β) signaling.
The Journal of biological chemistry
Ikeno S,Nakano N,Sano K,Minowa T,Sato W,Akatsu R,Sakata N,Hanagata N,Fujii M,Itoh F,Itoh S
Fri Mar 29 00:00:00 EDT 2019
Expansion, isolation and first characterization of bovine Th17 lymphocytes.
Scientific reports
Cunha P,Vern YL,Gitton C,Germon P,Foucras G,Rainard P
Wed Nov 06 00:00:00 EST 2019
Cardiac fibroblast activation and hyaluronan synthesis in response to hyperglycemia and diet-induced insulin resistance.
Scientific reports
Gorski DJ,Petz A,Reichert C,Twarock S,Grandoch M,Fischer JW
Tue Feb 12 00:00:00 EST 2019
Functional Screening Identifies MicroRNAs as Multi-Cellular Regulators of Heart Failure.
Scientific reports
Verjans R,Derks WJA,Korn K,Sönnichsen B,van Leeuwen REW,Schroen B,van Bilsen M,Heymans S
Mon Apr 15 00:00:00 EDT 2019
α11β1 Integrin is Induced in a Subset of Cancer-Associated Fibroblasts in Desmoplastic Tumor Stroma and Mediates In Vitro Cell Migration.
Cancers
Zeltz C,Alam J,Liu H,Erusappan PM,Hoschuetzky H,Molven A,Parajuli H,Cukierman E,Costea DE,Lu N,Gullberg D
100-21C was used in Sample Preparation (Western Blotting) to investigate integrin α11β1 in non-small cell lung cancer and neck squamous cell carcinoma.
Sat Jun 01 00:00:00 EDT 2019
α11β1 Integrin is Induced in a Subset of Cancer-Associated Fibroblasts in Desmoplastic Tumor Stroma and Mediates In Vitro Cell Migration.
Cancers
Zeltz C,Alam J,Liu H,Erusappan PM,Hoschuetzky H,Molven A,Parajuli H,Cukierman E,Costea DE,Lu N,Gullberg D
100-21C was used in Sample Preparation (Western Blotting) to investigate integrin α11β1 in non-small cell lung cancer and neck squamous cell carcinoma.
Sat Jun 01 00:00:00 EDT 2019
TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells.
Journal of experimental & clinical cancer research : CR
He R,Wang M,Zhao C,Shen M,Yu Y,He L,Zhao Y,Chen H,Shi X,Zhou M,Pan S,Liu Y,Guo X,Li X,Qin R
100-21C was used in In vivo experiments to highlight the potential utility of suppressing TFEB-driven autophagy to block PC metastasis.
Tue Aug 06 00:00:00 EDT 2019
The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes.
Cell research
Chen J,Cai Z,Bai M,Yu X,Zhang C,Cao C,Hu X,Wang L,Su R,Wang D,Wang L,Yao Y,Ye R,Hou B,Yu Y,Yu S,Li J,Xue Y
100-21C was used in In vitro experiments to identify an RNA-binding protein that is both required and sufficient to define activation-induced cytidine deaminase-binding sites genome-wide in activated B cells.
Mon Oct 01 00:00:00 EDT 2018
The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes.
Cell research
Chen J,Cai Z,Bai M,Yu X,Zhang C,Cao C,Hu X,Wang L,Su R,Wang D,Wang L,Yao Y,Ye R,Hou B,Yu Y,Yu S,Li J,Xue Y
100-21C was used in In vitro experiments to identify an RNA-binding protein that is both required and sufficient to define activation-induced cytidine deaminase-binding sites genome-wide in activated B cells.
Mon Oct 01 00:00:00 EDT 2018
Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression.
Cell metabolism
Cong J,Wang X,Zheng X,Wang D,Fu B,Sun R,Tian Z,Wei H
100-21C was used in Cell Culture to identify novel mechanisms in natural killer cell dysfunction.
Tue Aug 07 00:00:00 EDT 2018
BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation.
The Journal of experimental medicine
Deason K,Troutman TD,Jain A,Challa DK,Mandraju R,Brewer T,Ward ES,Pasare C
Mon Sep 03 00:00:00 EDT 2018
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
The Journal of experimental medicine
Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW
Mon Mar 05 00:00:00 EST 2018
USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.
The Journal of experimental medicine
Chen S,Yun F,Yao Y,Cao M,Zhang Y,Wang J,Song X,Qian Y
Mon Nov 05 00:00:00 EST 2018
SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.
The EMBO journal
Findlay S,Heath J,Luo VM,Malina A,Morin T,Coulombe Y,Djerir B,Li Z,Samiei A,Simo-Cheyou E,Karam M,Bagci H,Rahat D,Grapton D,Lavoie EG,Dove C,Khaled H,Kuasne H,Mann KK,Klein KO,Greenwood CM,Tabach Y,Park M,Côté JF,Masson JY,Maréchal A,Orthwein A
Fri Sep 14 00:00:00 EDT 2018
MiR-125a-5p ameliorates monocrotaline-induced pulmonary arterial hypertension by targeting the TGF-β1 and IL-6/STAT3 signaling pathways.
Experimental & molecular medicine
Cai Z,Li J,Zhuang Q,Zhang X,Yuan A,Shen L,Kang K,Qu B,Tang Y,Pu J,Gou D,Shen J
Fri Apr 27 00:00:00 EDT 2018
Loss of EMILIN-1 Enhances Arteriolar Myogenic Tone Through TGF-β (Transforming Growth Factor-β)-Dependent Transactivation of EGFR (Epidermal Growth Factor Receptor) and Is Relevant for Hypertension in Mice and Humans.
Arteriosclerosis, thrombosis, and vascular biology
Carnevale D,Facchinello N,Iodice D,Bizzotto D,Perrotta M,De Stefani D,Pallante F,Carnevale L,Ricciardi F,Cifelli G,Da Ros F,Casaburo M,Fardella S,Bonaldo P,Innocenzi G,Rizzuto R,Braghetta P,Lembo G,Bressan GM
100-21C was used in Cell Culture to implicate an unexpected role of the TGF-β-EGFR pathway in hypertension with current translational perspectives.
Mon Oct 01 00:00:00 EDT 2018
Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures.
EMBO reports
Sousa C,Golebiewska A,Poovathingal SK,Kaoma T,Pires-Afonso Y,Martina S,Coowar D,Azuaje F,Skupin A,Balling R,Biber K,Niclou SP,Michelucci A
Thu Nov 01 00:00:00 EDT 2018
Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2.
Journal of immunology (Baltimore, Md. : 1950)
Lee S,Kong JS,You S,Kwon HM,Yoo SA,Cho CS,Kim WU
Sun Jul 15 00:00:00 EDT 2018
A Tolerogenic Artificial APC Durably Ameliorates Experimental Autoimmune Encephalomyelitis by Directly and Selectively Modulating Myelin Peptide-Autoreactive CD4+ and CD8+ T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Wan X,Pei W,Shahzad KA,Zhang L,Song S,Jin X,Wang L,Zhao C,Shen C
Wed Aug 15 00:00:00 EDT 2018
Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Fuseini H,Yung JA,Cephus JY,Zhang J,Goleniewska K,Polosukhin VV,Peebles RS,Newcomb DC
Mon Oct 01 00:00:00 EDT 2018
The 3p14.2 tumour suppressor ADAMTS9 is inactivated by promoter CpG methylation and inhibits tumour cell growth in breast cancer.
Journal of cellular and molecular medicine
Shao B,Feng Y,Zhang H,Yu F,Li Q,Tan C,Xu H,Ying J,Li L,Yang D,Peng W,Tang J,Li S,Ren G,Tao Q,Xiang T
100-21C was used in Cell Culture to analyse ADAMTS9 expression and methylation in breast cancer cell lines and tissue samples to suggest that ADAMTS9 is a tumour suppressor gene (TSG) epigenetically inactivated in breast cancer, which functions through blocking EGFR- and TGFβ1/TβR(I/II)-activated AKT signaling.
Thu Feb 01 00:00:00 EST 2018
αII-spectrin and βII-spectrin do not affect TGFβ1-induced myofibroblast differentiation.
Cell and tissue research
Piersma B,Wouters OY,Bank RA
100-21C was used in In vitro experiments to suggest that αII- and βII-spectrin do not regulate cell adhesion, cell size and YAP localization in human dermal fibroblasts and are not required for the dermal myofibroblast phenotypical switch despite the diverse roles of spectrins in a variety of other cells.
Mon Oct 01 00:00:00 EDT 2018
Knockdown of FUT3 disrupts the proliferation, migration, tumorigenesis and TGF-β induced EMT in pancreatic cancer cells.
Oncology letters
Zhan L,Chen L,Chen Z
100-21C was used in Cell Culture to suggest that the knockdown of FUT3 inhibits the tumorigenesis in vivo and FUT3 may be a promising target aiming at reducing the metastatic virulence of pancreatic cancer cells.
Sun Jul 01 00:00:00 EDT 2018
The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development.
Nature communications
Wojciech S,Ahmad R,Belaid-Choucair Z,Journé AS,Gallet S,Dam J,Daulat A,Ndiaye-Lobry D,Lahuna O,Karamitri A,Guillaume JL,Do Cruzeiro M,Guillonneau F,Saade A,Clément N,Courivaud T,Kaabi N,Tadagaki K,Delagrange P,Prévot V,Hermine O,Prunier C,Jockers R
Fri Mar 23 00:00:00 EDT 2018
2-aminopurine suppresses the TGF-β1-induced epithelial-mesenchymal transition and attenuates bleomycin-induced pulmonary fibrosis.
Cell death discovery
Weng D,Chen JX,Li HH,Liu F,Zhou LD,Liu HP,Zheng RJ,Jiang Y,Liu ZH,Ge B
Sat Dec 01 00:00:00 EST 2018
NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
Nature communications
Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II
Tue May 08 00:00:00 EDT 2018
Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis.
Cell death & disease
Zhang Z,Qu J,Zheng C,Zhang P,Zhou W,Cui W,Mo X,Li L,Xu L,Gao J
Tue Jan 23 00:00:00 EST 2018
Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis.
Cell death & disease
Zhang Z,Qu J,Zheng C,Zhang P,Zhou W,Cui W,Mo X,Li L,Xu L,Gao J
Tue Jan 23 00:00:00 EST 2018
N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination.
Scientific reports
Yu X,Cheng G,Zhang L,Zhang Y,Wang Q,Zhao M,Zeng L,Hu Y,Feng L
Wed Sep 19 00:00:00 EDT 2018
Oleanolic acid attenuates TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells.
BMC complementary and alternative medicine
He WM,Yin JQ,Cheng XD,Lu X,Ni L,Xi Y,Yin GD,Lu GY,Sun W,Wei MG
100-21C was used in Cell Culture to evaluate the effects of oleanolic acid on epithelial-to-mesenchymal transition of renal proximal tubular epithelial cell line (NRK-52E) induced by TGF-β1, and to elucidate its underlying mechanism.
Wed Jul 04 00:00:00 EDT 2018
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.
Nature communications
Hsieh WC,Hsu TS,Chang YJ,Lai MZ
Wed Jan 31 00:00:00 EST 2018
Optogenetic control of epithelial-mesenchymal transition in cancer cells.
Scientific reports
Zhou X,Wang J,Chen J,Qi Y,Jin L,Qian X,Wang X,Chen Q,Liu X,Xu Y
Thu Sep 20 00:00:00 EDT 2018
Generation of Induced Pluripotent Stem Cells from Patients with COL3A1 Mutations and Differentiation to Smooth Muscle Cells for ECM-Surfaceome Analyses.
Methods in molecular biology (Clifton, N.J.)
He J,Weng Z,Wu SCM,Boheler KR
100-21C was used in Cell Culture to generate iPSCs from human fibroblasts containing mutations in COL3A1, and characterize the putative iPSCs in vivo and in vitro to ensure potency and differentiation potential.
Tue Aug 14 00:00:00 EDT 2018
Kindlin-2 regulates hepatic stellate cells activation and liver fibrogenesis.
Cell death discovery
Yu J,Hu Y,Gao Y,Li Q,Zeng Z,Li Y,Chen H
Thu Oct 01 00:00:00 EDT 2020
Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.
Scientific reports
Sahakyan V,Duelen R,Tam WL,Roberts SJ,Grosemans H,Berckmans P,Ceccarelli G,Pelizzo G,Broccoli V,Deprest J,Luyten FP,Verfaillie CM,Sampaolesi M
Tue Feb 13 00:00:00 EST 2018
Development of new method to enrich human iPSC-derived renal progenitors using cell surface markers.
Scientific reports
Hoshina A,Kawamoto T,Sueta SI,Mae SI,Araoka T,Tanaka H,Sato Y,Yamagishi Y,Osafune K
Mon Apr 23 00:00:00 EDT 2018
Ethanol sensitizes hepatocytes for TGF-β-triggered apoptosis.
Cell death & disease
Gaitantzi H,Meyer C,Rakoczy P,Thomas M,Wahl K,Wandrer F,Bantel H,Alborzinia H,Wölfl S,Ehnert S,Nüssler A,Bergheim I,Ciuclan L,Ebert M,Breitkopf-Heinlein K,Dooley S
Fri Jan 19 00:00:00 EST 2018
Discovery of stimulation-responsive immune enhancers with CRISPR activation.
Nature
Simeonov DR,Gowen BG,Boontanrart M,Roth TL,Gagnon JD,Mumbach MR,Satpathy AT,Lee Y,Bray NL,Chan AY,Lituiev DS,Nguyen ML,Gate RE,Subramaniam M,Li Z,Woo JM,Mitros T,Ray GJ,Curie GL,Naddaf N,Chu JS,Ma H,Boyer E,Van Gool F,Huang H,Liu R,Tobin VR,Schumann K,Daly MJ,Farh KK,Ansel KM,Ye CJ,Greenleaf WJ,Anderson MS,Bluestone JA,Chang HY,Corn JE,Marson A
Thu Sep 07 00:00:00 EDT 2017
Interspecies Chimerism with Mammalian Pluripotent Stem Cells.
Cell
Wu J,Platero-Luengo A,Sakurai M,Sugawara A,Gil MA,Yamauchi T,Suzuki K,Bogliotti YS,Cuello C,Morales Valencia M,Okumura D,Luo J,Vilariño M,Parrilla I,Soto DA,Martinez CA,Hishida T,Sánchez-Bautista S,Martinez-Martinez ML,Wang H,Nohalez A,Aizawa E,Martinez-Redondo P,Ocampo A,Reddy P,Roca J,Maga EA,Esteban CR,Berggren WT,Nuñez Delicado E,Lajara J,Guillen I,Guillen P,Campistol JM,Martinez EA,Ross PJ,Izpisua Belmonte JC
Thu Jan 26 00:00:00 EST 2017
An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function.
Immunity
Oh H,Grinberg-Bleyer Y,Liao W,Maloney D,Wang P,Wu Z,Wang J,Bhatt DM,Heise N,Schmid RM,Hayden MS,Klein U,Rabadan R,Ghosh S
Tue Sep 19 00:00:00 EDT 2017
Xanthine dehydrogenase downregulation promotes TGFβ signaling and cancer stem cell-related gene expression in hepatocellular carcinoma.
Oncogenesis
Chen GL,Ye T,Chen HL,Zhao ZY,Tang WQ,Wang LS,Xia JL
Mon Sep 25 00:00:00 EDT 2017
Activation of Wnt/β-catenin signalling is required for TGF-β/Smad2/3 signalling during myofibroblast proliferation.
Journal of cellular and molecular medicine
Xu L,Cui WH,Zhou WC,Li DL,Li LC,Zhao P,Mo XT,Zhang Z,Gao J
100-21C was used in Sample Preparation (Western Blotting) to study the level of sustained expression of fibrosis iconic proteins (vimentin, α-SMA and collagen I) and the TGF-β signalling pathway that include smad2/3 and its phosphorylated form p-smad2/3 to provide insight into the mechanisms by which epithelial and mesenchymal cells contribute to lung fibrosis.
Tue Aug 01 00:00:00 EDT 2017
Activation of Wnt/β-catenin signalling is required for TGF-β/Smad2/3 signalling during myofibroblast proliferation.
Journal of cellular and molecular medicine
Xu L,Cui WH,Zhou WC,Li DL,Li LC,Zhao P,Mo XT,Zhang Z,Gao J
100-21C was used in Sample Preparation (Western Blotting) to study the level of sustained expression of fibrosis iconic proteins (vimentin, α-SMA and collagen I) and the TGF-β signalling pathway that include smad2/3 and its phosphorylated form p-smad2/3 to provide insight into the mechanisms by which epithelial and mesenchymal cells contribute to lung fibrosis.
Tue Aug 01 00:00:00 EDT 2017
Trichostatin A ameliorates renal tubulointerstitial fibrosis through modulation of the JNK-dependent Notch-2 signaling pathway.
Scientific reports
Tung CW,Hsu YC,Cai CJ,Shih YH,Wang CJ,Chang PJ,Lin CL
Fri Nov 03 00:00:00 EDT 2017
Ascorbic acid promotes a TGFβ1-induced myofibroblast phenotype switch.
Physiological reports
Piersma B,Wouters OY,de Rond S,Boersema M,Gjaltema RAF,Bank RA
Fri Sep 01 00:00:00 EDT 2017
Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.
Nature communications
Malik S,Sadhu S,Elesela S,Pandey RP,Chawla AS,Sharma D,Panda L,Rathore D,Ghosh B,Ahuja V,Awasthi A
Mon Oct 09 00:00:00 EDT 2017
Upregulation of microRNA-4417 and Its Target Genes Contribute to Nickel Chloride-promoted Lung Epithelial Cell Fibrogenesis and Tumorigenesis.
Scientific reports
Wu CH,Hsiao YM,Yeh KT,Tsou TC,Chen CY,Wu MF,Ko JL
Fri Nov 10 00:00:00 EST 2017
Non-thermal atmospheric plasma ameliorates imiquimod-induced psoriasis-like skin inflammation in mice through inhibition of immune responses and up-regulation of PD-L1 expression.
Scientific reports
Lee YS,Lee MH,Kim HJ,Won HR,Kim CH
Tue Nov 14 00:00:00 EST 2017
TRI Microspheres prevent key signs of dry eye disease in a murine, inflammatory model.
Scientific reports
Ratay ML,Balmert SC,Acharya AP,Greene AC,Meyyappan T,Little SR
Wed Dec 13 00:00:00 EST 2017
Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction.
JCI insight
Shimizu T,Narang N,Chen P,Yu B,Knapp M,Janardanan J,Blair J,Liao JK
Thu Jul 06 00:00:00 EDT 2017
Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction.
JCI insight
Shimizu T,Narang N,Chen P,Yu B,Knapp M,Janardanan J,Blair J,Liao JK
Thu Jul 06 00:00:00 EDT 2017
Co-expression of 1α-hydroxylase and vitamin D receptor in human articular chondrocytes.
BMC musculoskeletal disorders
Hansen AK,Figenschau Y,Zubiaurre-Martinez I
100-21C was used in Cell Culture to study whether resident chondrocytes in human articular cartilage and in subculture express vitamin D receptor (VDR) and the enzyme that hydroxylates the prohormone 25(OH)D3 to the active hormone 1α,25(OH)2D3, namely 1α-hydroxylase (CYP27B1).
Mon Nov 06 00:00:00 EST 2017
Quantitative and organisational changes in mature extracellular matrix revealed through high-content imaging of total protein fluorescently stained in situ.
Scientific reports
Holdsworth G,Bon H,Bergin M,Qureshi O,Paveley R,Atkinson J,Huang L,Tewari R,Twomey B,Johnson T
Wed Aug 30 00:00:00 EDT 2017
Quantitative and organisational changes in mature extracellular matrix revealed through high-content imaging of total protein fluorescently stained in situ.
Scientific reports
Holdsworth G,Bon H,Bergin M,Qureshi O,Paveley R,Atkinson J,Huang L,Tewari R,Twomey B,Johnson T
Wed Aug 30 00:00:00 EDT 2017
Matrix stiffness regulates migration of human lung fibroblasts.
Physiological reports
Asano S,Ito S,Takahashi K,Furuya K,Kondo M,Sokabe M,Hasegawa Y
Mon May 01 00:00:00 EDT 2017
Tumor-associated macrophages promote tumor metastasis via the TGF-β/SOX9 axis in non-small cell lung cancer.
Oncotarget
Zhang S,Che D,Yang F,Chi C,Meng H,Shen J,Qi L,Liu F,Lv L,Li Y,Meng Q,Liu J,Shang L,Yu Y
100-21C was used in Cell Culture to indicate that TGF-β secreted by TAMs promotes SOX9 expression via the C-jun/SMAD3 pathway, thereby promoting tumor metastasis, so the TGF-β/SOX9 axis may therefore be an effective target for the treatment of lung cancer.
Tue Nov 21 00:00:00 EST 2017
c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma.
The Journal of clinical investigation
Huang M,Liu T,Ma P,Mitteer RA,Zhang Z,Kim HJ,Yeo E,Zhang D,Cai P,Li C,Zhang L,Zhao B,Roccograndi L,O'Rourke DM,Dahmane N,Gong Y,Koumenis C,Fan Y
Mon May 02 00:00:00 EDT 2016
MicroRNA-27b Enhances the Hepatic Regenerative Properties of Adipose-Derived Mesenchymal Stem Cells.
Molecular therapy. Nucleic acids
Chen KD,Huang KT,Lin CC,Weng WT,Hsu LW,Goto S,Nakano T,Lai CY,Kung CP,Chiu KW,Wang CC,Cheng YF,Ma YY,Chen CL
Tue Feb 02 00:00:00 EST 2016
Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-β1.
Stem cells (Dayton, Ohio)
Barcellos-de-Souza P,Comito G,Pons-Segura C,Taddei ML,Gori V,Becherucci V,Bambi F,Margheri F,Laurenzana A,Del Rosso M,Chiarugi P
Sat Oct 01 00:00:00 EDT 2016
TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development.
Journal of immunology (Baltimore, Md. : 1950)
Nagashima H,Okuyama Y,Hayashi T,Ishii N,So T
Sun May 15 00:00:00 EDT 2016
Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.
Nature communications
O'Leary CE,Riling CR,Spruce LA,Ding H,Kumar S,Deng G,Liu Y,Seeholzer SH,Oliver PM
Mon Apr 18 00:00:00 EDT 2016
Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer.
The Journal of biological chemistry
Topalovski M,Hagopian M,Wang M,Brekken RA
100-21C was used in Sample Preparation (Western Blotting) to investigate the signalling axis that induces Fibulin-5 expression in pancreatic ductal adenocarcinoma and a potential strategy to block its production.
Fri Oct 14 00:00:00 EDT 2016
Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis.
Scientific reports
Zhou W,Mo X,Cui W,Zhang Z,Li D,Li L,Xu L,Yao H,Gao J
Fri Dec 16 00:00:00 EST 2016
Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.
Nature communications
Saintamand A,Vincent-Fabert C,Garot A,Rouaud P,Oruc Z,Magnone V,Cogné M,Denizot Y
Wed Feb 17 00:00:00 EST 2016
FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.
Nature communications
Bosma M,Gerling M,Pasto J,Georgiadi A,Graham E,Shilkova O,Iwata Y,Almer S,Söderman J,Toftgård R,Wermeling F,Boström EA,Boström PA
Tue Apr 12 00:00:00 EDT 2016
Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.
Scientific reports
Kawalkowska J,Quirke AM,Ghari F,Davis S,Subramanian V,Thompson PR,Williams RO,Fischer R,La Thangue NB,Venables PJ
Mon May 23 00:00:00 EDT 2016
The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling.
Scientific reports
Morris MA,Dawson CW,Laverick L,Davis AM,Dudman JP,Raveenthiraraj S,Ahmad Z,Yap LF,Young LS
Tue Jan 19 00:00:00 EST 2016
Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes.
The Journal of biological chemistry
Chen S,Feng T,Vujić Spasić M,Altamura S,Breitkopf-Heinlein K,Altenöder J,Weiss TS,Dooley S,Muckenthaler MU
Fri Jun 17 00:00:00 EDT 2016
Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis.
American journal of respiratory and critical care medicine
Xie N,Tan Z,Banerjee S,Cui H,Ge J,Liu RM,Bernard K,Thannickal VJ,Liu G
Tue Dec 15 00:00:00 EST 2015
Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis.
American journal of respiratory and critical care medicine
Xie N,Tan Z,Banerjee S,Cui H,Ge J,Liu RM,Bernard K,Thannickal VJ,Liu G
Tue Dec 15 00:00:00 EST 2015
Pit- and trench-forming osteoclasts: a distinction that matters.
Bone research
Merrild DM,Pirapaharan DC,Andreasen CM,Kjærsgaard-Andersen P,Møller AM,Ding M,Delaissé JM,Søe K
Tue Dec 15 00:00:00 EST 2015
T-cell receptor α enhancer is inactivated in αβ T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
del Blanco B,Angulo Ú,Krangel MS,Hernández-Munain C
Tue Apr 07 00:00:00 EDT 2015
Reduced granulation tissue and wound strength in the absence of α11β1 integrin.
The Journal of investigative dermatology
Schulz JN,Zeltz C,Sørensen IW,Barczyk M,Carracedo S,Hallinger R,Niehoff A,Eckes B,Gullberg D
Fri May 01 00:00:00 EDT 2015
CD49f Acts as an Inflammation Sensor to Regulate Differentiation, Adhesion, and Migration of Human Mesenchymal Stem Cells.
Stem cells (Dayton, Ohio)
Yang Z,Dong P,Fu X,Li Q,Ma S,Wu D,Kang N,Liu X,Yan L,Xiao R
Tue Sep 01 00:00:00 EDT 2015
Foxo1 Is a T Cell-Intrinsic Inhibitor of the RORγt-Th17 Program.
Journal of immunology (Baltimore, Md. : 1950)
Lainé A,Martin B,Luka M,Mir L,Auffray C,Lucas B,Bismuth G,Charvet C
Sat Aug 15 00:00:00 EDT 2015
Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction.
Molecular medicine reports
Baba I,Egi Y,Utsumi H,Kakimoto T,Suzuki K
100-21C was used in In vitro experiments to suggest that the inhibition of ROCK activity by fasudil suppressed the transformation of renal intrinsic cells into the myofibroblast cells, and attenuated the infiltration of macrophages, without inhibiting the expression or the activation of cytokine/chemokines, in the progression of renal interstitial fibrosis.
Tue Dec 01 00:00:00 EST 2015
Tetramethylpyrazine inhibits CTGF and Smad2/3 expression and proliferation of hepatic stellate cells.
Biotechnology, biotechnological equipment
Li J,Dong N,Cheng S,Li X,Wang W,Xiang Y
100-21C was used in In vitro experiments to study the effects of tetramethylpyrazine (TMP) on the proliferation of hepatic stellate cells-T6 (HSC-T6), and the expression of connective tissue growth factor (CTGF) and Smad2/3 in these cells, HSC-T6 cells were cultured with TMP at different concentrations after transforming growth factor-β1 (TGF-β1) stimulation to provide cellular and molecular bases for further application of TMP in the clinical treatment for hepatic fibrosis.
Fri Jan 02 00:00:00 EST 2015
Jagged-1 signaling suppresses the IL-6 and TGF-β treatment-induced Th17 cell differentiation via the reduction of RORγt/IL-17A/IL-17F/IL-23a/IL-12rb1.
Scientific reports
Wang Y,Xing F,Ye S,Xiao J,Di J,Zeng S,Liu J
Wed Feb 04 00:00:00 EST 2015
Up-regulation of Serum MiR-130b-3p Level is Associated with Renal Damage in Early Lupus Nephritis.
Scientific reports
Wang W,Mou S,Wang L,Zhang M,Shao X,Fang W,Lu R,Qi C,Fan Z,Cao Q,Wang Q,Fang Y,Ni Z
Fri Aug 28 00:00:00 EDT 2015
Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
Nature communications
Aspalter IM,Gordon E,Dubrac A,Ragab A,Narloch J,Vizán P,Geudens I,Collins RT,Franco CA,Abrahams CL,Thurston G,Fruttiger M,Rosewell I,Eichmann A,Gerhardt H
100-21C was used in Cell Culture to demonstrate that Notch downregulates Nrp1, thus relieving the inhibition of Alk1 and Alk5, thereby driving stalk-cell behaviour.
Wed Jun 17 00:00:00 EDT 2015
Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss.
Nature communications
Harre U,Lang SC,Pfeifle R,Rombouts Y,Frühbeißer S,Amara K,Bang H,Lux A,Koeleman CA,Baum W,Dietel K,Gröhn F,Malmström V,Klareskog L,Krönke G,Kocijan R,Nimmerjahn F,Toes RE,Herrmann M,Scherer HU,Schett G
Tue Mar 31 00:00:00 EDT 2015
IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3.
Scientific reports
Mailer RK,Joly AL,Liu S,Elias S,Tegner J,Andersson J
Tue Oct 06 00:00:00 EDT 2015
Fibroblast Growth Factors and Vascular Endothelial Growth Factor Promote Cardiac Reprogramming under Defined Conditions.
Stem cell reports
Yamakawa H,Muraoka N,Miyamoto K,Sadahiro T,Isomi M,Haginiwa S,Kojima H,Umei T,Akiyama M,Kuishi Y,Kurokawa J,Furukawa T,Fukuda K,Ieda M
Tue Dec 08 00:00:00 EST 2015
miR-134 Modulates the Proliferation of Human Cardiomyocyte Progenitor Cells by Targeting Meis2.
International journal of molecular sciences
Wu YH,Zhao H,Zhou LP,Zhao CX,Wu YF,Zhen LX,Li J,Ge DX,Xu L,Lin L,Liu Y,Liang DD,Chen YH
100-21C was used in Cell Culture to elucidate the role and mechanisms of miR-134 in cardiogenesis.
Fri Oct 23 00:00:00 EDT 2015
Phenotypic and functional characterization of long-term cryopreserved human adipose-derived stem cells.
Scientific reports
Yong KW,Pingguan-Murphy B,Xu F,Abas WA,Choi JR,Omar SZ,Azmi MA,Chua KH,Wan Safwani WK
Wed Apr 15 00:00:00 EDT 2015
Chemically defined generation of human cardiomyocytes.
Nature methods
Burridge PW,Matsa E,Shukla P,Lin ZC,Churko JM,Ebert AD,Lan F,Diecke S,Huber B,Mordwinkin NM,Plews JR,Abilez OJ,Cui B,Gold JD,Wu JC
Fri Aug 01 00:00:00 EDT 2014
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
Nature immunology
Nagashima H,Okuyama Y,Asao A,Kawabe T,Yamaki S,Nakano H,Croft M,Ishii N,So T
100-21C was used in In vitro experiments to identify TRAF5 as a negative regulator of the IL-6 receptor signalling pathway that limits the induction of proinflammatory CD4(+) T cells.
Thu May 01 00:00:00 EDT 2014
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells.
The Journal of experimental medicine
Gomez-Rodriguez J,Wohlfert EA,Handon R,Meylan F,Wu JZ,Anderson SM,Kirby MR,Belkaid Y,Schwartzberg PL
Mon Mar 10 00:00:00 EDT 2014
Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression.
Proceedings of the National Academy of Sciences of the United States of America
Liao W,Spolski R,Li P,Du N,West EE,Ren M,Mitra S,Leonard WJ
Tue Mar 04 00:00:00 EST 2014
JAK2-STAT3 blockade by AG490 suppresses autoimmune arthritis in mice via reciprocal regulation of regulatory T Cells and Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Park JS,Lee J,Lim MA,Kim EK,Kim SM,Ryu JG,Lee JH,Kwok SK,Park KS,Kim HY,Park SH,Cho ML
Thu May 01 00:00:00 EDT 2014
Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization.
Scientific reports
Tatano Y,Shimizu T,Tomioka H
Thu Feb 20 00:00:00 EST 2014
Directed differentiation of embryonic origin-specific vascular smooth muscle subtypes from human pluripotent stem cells.
Nature protocols
Cheung C,Bernardo AS,Pedersen RA,Sinha S
100-21C was used in Cell Culture to describe how human pluripotent stem cells can be differentiated into distinct populations of SMC subtypes under chemically defined conditions.
Tue Apr 01 00:00:00 EDT 2014
Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages.
Nature communications
Ling GS,Bennett J,Woollard KJ,Szajna M,Fossati-Jimack L,Taylor PR,Scott D,Franzoso G,Cook HT,Botto M
Tue Nov 24 00:00:00 EST 2015
TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion.
Cell death & disease
Joseph JV,Conroy S,Tomar T,Eggens-Meijer E,Bhat K,Copray S,Walenkamp AM,Boddeke E,Balasubramanyian V,Wagemakers M,den Dunnen WF,Kruyt FA
Thu Oct 02 00:00:00 EDT 2014
The aPKCι blocking agent ATM negatively regulates EMT and invasion of hepatocellular carcinoma.
Cell death & disease
Ma CQ,Yang Y,Wang JM,Du GS,Shen Q,Liu Y,Zhang J,Hu JL,Zhu P,Qi WP,Qian YW,Fu Y
Thu Mar 20 00:00:00 EDT 2014
miR-10a regulates proliferation of human cardiomyocyte progenitor cells by targeting GATA6.
PloS one
Liang D,Zhen L,Yuan T,Huang J,Deng F,Zhang H,Pan L,Liu Y,The E,Yu Z,Zhu W,Zhang Y,Li L,Peng L,Li J,Chen YH
100-21C was used in Cell Culture to indicate that miR-10a could effectively modulate the proliferation of human CMPCs by targeting GATA6. The finding provides novel insights into the potency of miR-10a during heart development.
Mon Nov 09 00:00:00 EST 2015
Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways.
Nucleic acids research
Wang M,Saha J,Hada M,Anderson JA,Pluth JM,O'Neill P,Cucinotta FA
Tue Jan 01 00:00:00 EST 2013
In vitro growth factor-induced bio engineering of mature articular cartilage.
Biomaterials
Khan IM,Francis L,Theobald PS,Perni S,Young RD,Prokopovich P,Conlan RS,Archer CW
Fri Feb 01 00:00:00 EST 2013
ATG5 regulates plasma cell differentiation.
Autophagy
Conway KL,Kuballa P,Khor B,Zhang M,Shi HN,Virgin HW,Xavier RJ
100-21C was used in In vitro experiments to study mice deficient in ATG5 in T and B cell development function.
Mon Apr 01 00:00:00 EDT 2013
LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1.
Proceedings of the National Academy of Sciences of the United States of America
Ren S,Johnson BG,Kida Y,Ip C,Davidson KC,Lin SL,Kobayashi A,Lang RA,Hadjantonakis AK,Moon RT,Duffield JS
Tue Jan 22 00:00:00 EST 2013
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R
Tue Jan 01 00:00:00 EST 2013
Caveolin-1 abrogates TGF-β mediated hepatocyte apoptosis.
Cell death & disease
Meyer C,Liu Y,Kaul A,Peipe I,Dooley S
Thu Jan 17 00:00:00 EST 2013
Does malaria affect placental development? Evidence from in vitro models.
PloS one
Umbers AJ,Stanisic DI,Ome M,Wangnapi R,Hanieh S,Unger HW,Robinson LJ,Lufele E,Baiwog F,Siba PM,King CL,Beeson JG,Mueller I,Aplin JD,Glazier JD,Rogerson SJ
Mon Jul 22 00:00:00 EDT 2013
TGF-ß1 enhances the BMP-2-induced chondrogenesis of bovine synovial explants and arrests downstream differentiation at an early stage of hypertrophy.
PloS one
Shintani N,Siebenrock KA,Hunziker EB
Tue Aug 20 00:00:00 EDT 2013
Transforming growth factor-β1 and -β2 in gastric precancer and cancer and roles in tumor-cell interactions with peripheral blood mononuclear cells in vitro.
PloS one
Ma GF,Miao Q,Zeng XQ,Luo TC,Ma LL,Liu YM,Lian JJ,Gao H,Chen SY
Fri Aug 02 00:00:00 EDT 2013
Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.
The Journal of biological chemistry
Spender LC,Carter MJ,O'Brien DI,Clark LJ,Yu J,Michalak EM,Happo L,Cragg MS,Inman GJ
Fri Feb 15 00:00:00 EST 2013
The microbial capsular polysaccharide galactoxylomannan inhibits IL-17A production in circulating T cells from rheumatoid arthritis patients.
PloS one
Pericolini E,Alunno A,Gabrielli E,Bartoloni E,Cenci E,Chow SK,Bistoni G,Casadevall A,Gerli R,Vecchiarelli A
Tue Jul 02 00:00:00 EDT 2013
Human embryonic stem cell derived mesenchymal progenitors express cardiac markers but do not form contractile cardiomyocytes.
PloS one
Raynaud CM,Halabi N,Elliott DA,Pasquier J,Elefanty AG,Stanley EG,Rafii A
Fri Aug 02 00:00:00 EDT 2013
The autoregulatory feedback loop of microRNA-21/programmed cell death protein 4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development.
The Journal of biological chemistry
Zhang Z,Zha Y,Hu W,Huang Z,Gao Z,Zang Y,Chen J,Dong L,Zhang J
Fri Dec 27 00:00:00 EST 2013
Transgenes of the mouse immunoglobulin heavy chain locus, lacking distal elements in the 3' regulatory region, are impaired for class switch recombination.
PloS one
Dunnick WA,Shi J,Fontaine C,Collins JT
100-21C was used in Cell Culture to study switch recombination using a transgene of the entire murine H chain constant region locus.
Mon Aug 05 00:00:00 EDT 2013
Protocadherins mediate dendritic self-avoidance in the mammalian nervous system.
Nature
Lefebvre JL,Kostadinov D,Chen WV,Maniatis T,Sanes JR
Thu Aug 23 00:00:00 EDT 2012
EMT and dissemination precede pancreatic tumor formation.
Cell
Rhim AD,Mirek ET,Aiello NM,Maitra A,Bailey JM,McAllister F,Reichert M,Beatty GL,Rustgi AK,Vonderheide RH,Leach SD,Stanger BZ
Fri Jan 20 00:00:00 EST 2012
Derivation of iPSCs in stirred suspension bioreactors.
Nature methods
Shafa M,Day B,Yamashita A,Meng G,Liu S,Krawetz R,Rancourt DE
Sun Apr 08 00:00:00 EDT 2012
Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance.
Immunity
Gulen MF,Bulek K,Xiao H,Yu M,Gao J,Sun L,Beurel E,Kaidanovich-Beilin O,Fox PL,DiCorleto PE,Wang JA,Qin J,Wald DN,Woodgett JR,Jope RS,Carman J,Dongre A,Li X
Fri Nov 16 00:00:00 EST 2012
Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion.
Blood
Kim YC,Bhairavabhotla R,Yoon J,Golding A,Thornton AM,Tran DQ,Shevach EM
Thu Mar 22 00:00:00 EDT 2012
Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells.
Blood
Hutter C,Kauer M,Simonitsch-Klupp I,Jug G,Schwentner R,Leitner J,Bock P,Steinberger P,Bauer W,Carlesso N,Minkov M,Gadner H,Stingl G,Kovar H,Kriehuber E
Thu Dec 20 00:00:00 EST 2012
SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection.
Cellular & molecular immunology
Zhang X,Han S,Kang Y,Guo M,Hong S,Liu F,Fu S,Wang L,Wang QX
Sat Sep 01 00:00:00 EDT 2012
Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets.
The Journal of clinical investigation
Li X,Murray F,Koide N,Goldstone J,Dann SM,Chen J,Bertin S,Fu G,Weinstein LS,Chen M,Corr M,Eckmann L,Insel PA,Raz E
Thu Mar 01 00:00:00 EST 2012
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.
The Journal of clinical investigation
Yiakouvaki A,Dimitriou M,Karakasiliotis I,Eftychi C,Theocharis S,Kontoyiannis DL
Sun Jan 01 00:00:00 EST 2012
DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection.
The Journal of clinical investigation
Oertli M,Sundquist M,Hitzler I,Engler DB,Arnold IC,Reuter S,Maxeiner J,Hansson M,Taube C,Quiding-Järbrink M,Müller A
Thu Mar 01 00:00:00 EST 2012
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.
The Journal of experimental medicine
Weiss JM,Bilate AM,Gobert M,Ding Y,Curotto de Lafaille MA,Parkhurst CN,Xiong H,Dolpady J,Frey AB,Ruocco MG,Yang Y,Floess S,Huehn J,Oh S,Li MO,Niec RE,Rudensky AY,Dustin ML,Littman DR,Lafaille JJ
Mon Sep 24 00:00:00 EDT 2012
Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer.
EMBO molecular medicine
Cano CE,Sandí MJ,Hamidi T,Calvo EL,Turrini O,Bartholin L,Loncle C,Secq V,Garcia S,Lomberk G,Kroemer G,Urrutia R,Iovanna JL
Sat Sep 01 00:00:00 EDT 2012
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Vaeth M,Schliesser U,Müller G,Reissig S,Satoh K,Tuettenberg A,Jonuleit H,Waisman A,Müller MR,Serfling E,Sawitzki BS,Berberich-Siebelt F
Tue Oct 02 00:00:00 EDT 2012
CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
Poppensieker K,Otte DM,Schürmann B,Limmer A,Dresing P,Drews E,Schumak B,Klotz L,Raasch J,Mildner A,Waisman A,Scheu S,Knolle P,Förster I,Prinz M,Maier W,Zimmer A,Alferink J
Tue Mar 06 00:00:00 EST 2012
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength.
Proceedings of the National Academy of Sciences of the United States of America
Baud'huin M,Solban N,Cornwall-Brady M,Sako D,Kawamoto Y,Liharska K,Lath D,Bouxsein ML,Underwood KW,Ucran J,Kumar R,Pobre E,Grinberg A,Seehra J,Canalis E,Pearsall RS,Croucher PI
Tue Jul 24 00:00:00 EDT 2012
Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions.
Proceedings of the National Academy of Sciences of the United States of America
Wang H,Shin DM,Abbasi S,Jain S,Kovalchuk AL,Beaty N,Chen S,Gonzalez-Garcia I,Morse HC
Tue Dec 04 00:00:00 EST 2012
PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation.
Cell death and differentiation
Iovino S,Oriente F,Botta G,Cabaro S,Iovane V,Paciello O,Viggiano D,Perruolo G,Formisano P,Beguinot F
Sun Jul 01 00:00:00 EDT 2012
PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation.
Cell death and differentiation
Iovino S,Oriente F,Botta G,Cabaro S,Iovane V,Paciello O,Viggiano D,Perruolo G,Formisano P,Beguinot F
Sun Jul 01 00:00:00 EDT 2012
Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients.
Breast cancer research : BCR
Román-Pérez E,Casbas-Hernández P,Pirone JR,Rein J,Carey LA,Lubet RA,Mani SA,Amos KD,Troester MA
Mon Mar 19 00:00:00 EDT 2012
Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin.
The Journal of cell biology
Winbanks CE,Weeks KL,Thomson RE,Sepulveda PV,Beyer C,Qian H,Chen JL,Allen JM,Lancaster GI,Febbraio MA,Harrison CA,McMullen JR,Chamberlain JS,Gregorevic P
Mon Jun 25 00:00:00 EDT 2012
Human papillomavirus type 8 interferes with a novel C/EBPβ-mediated mechanism of keratinocyte CCL20 chemokine expression and Langerhans cell migration.
PLoS pathogens
Sperling T,Ołdak M,Walch-Rückheim B,Wickenhauser C,Doorbar J,Pfister H,Malejczyk M,Majewski S,Keates AC,Smola S
Tue Jan 29 00:00:00 EST 2013
Thiol-ene photopolymerizations provide a facile method to encapsulate proteins and maintain their bioactivity.
Biomacromolecules
McCall JD,Anseth KS
Mon Aug 13 00:00:00 EDT 2012
MicroRNA-181a regulates local immune balance by inhibiting proliferation and immunosuppressive properties of mesenchymal stem cells.
Stem cells (Dayton, Ohio)
Liu L,Wang Y,Fan H,Zhao X,Liu D,Hu Y,Kidd AR,Bao J,Hou Y
Wed Aug 01 00:00:00 EDT 2012
Pharmacological modulation of human mesenchymal stem cell chondrogenesis by a chemically oversulfated polysaccharide of marine origin: potential application to cartilage regenerative medicine.
Stem cells (Dayton, Ohio)
Merceron C,Portron S,Vignes-Colombeix C,Rederstorff E,Masson M,Lesoeur J,Sourice S,Sinquin C,Colliec-Jouault S,Weiss P,Vinatier C,Guicheux J
Thu Mar 01 00:00:00 EST 2012
Pharmacological modulation of human mesenchymal stem cell chondrogenesis by a chemically oversulfated polysaccharide of marine origin: potential application to cartilage regenerative medicine.
Stem cells (Dayton, Ohio)
Merceron C,Portron S,Vignes-Colombeix C,Rederstorff E,Masson M,Lesoeur J,Sourice S,Sinquin C,Colliec-Jouault S,Weiss P,Vinatier C,Guicheux J
Thu Mar 01 00:00:00 EST 2012
Covalently tethered transforming growth factor beta in PEG hydrogels promotes chondrogenic differentiation of encapsulated human mesenchymal stem cells.
Drug delivery and translational research
McCall JD,Luoma JE,Anseth KS
Mon Oct 01 00:00:00 EDT 2012
Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity.
Arthritis research & therapy
Li Y,Zhao LD,Tong LS,Qian SN,Ren Y,Zhang L,Ding X,Chen Y,Wang YX,Zhang W,Zeng XF,Zhang FC,Tang FL,Zhang X,Ba DN,He W,Cao XT,Lipsky PE
Wed May 23 00:00:00 EDT 2012
Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950)
Ma J,Ding Y,Fang X,Wang R,Sun Z
Fri Jun 01 00:00:00 EDT 2012
IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner.
Journal of immunology (Baltimore, Md. : 1950)
Newcomb DC,Boswell MG,Huckabee MM,Goleniewska K,Dulek DE,Reiss S,Lukacs NW,Kolls JK,Peebles RS
Wed Feb 01 00:00:00 EST 2012
Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Kalim KW,Basler M,Kirk CJ,Groettrup M
Mon Oct 15 00:00:00 EDT 2012
Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor γ.
Journal of immunology (Baltimore, Md. : 1950)
Perry DJ,Yin Y,Telarico T,Baker HV,Dozmorov I,Perl A,Morel L
Sun Jul 15 00:00:00 EDT 2012
Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection.
Journal of immunology (Baltimore, Md. : 1950)
Panzer M,Sitte S,Wirth S,Drexler I,Sparwasser T,Voehringer D
Sun Jan 15 00:00:00 EST 2012
Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Eberle ME,Dalpke AH
Fri Jun 01 00:00:00 EDT 2012
IFN-γ receptor-deficient donor T cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor responses after allogeneic bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950)
Sun K,Hsiao HH,Li M,Ames E,Bouchlaka M,Welniak LA,Hagino T,Jagdeo J,Pai CC,Chen M,Blazar BR,Abedi M,Murphy WJ
Wed Aug 15 00:00:00 EDT 2012
Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Ramalingam R,Larmonier CB,Thurston RD,Midura-Kiela MT,Zheng SG,Ghishan FK,Kiela PR
Mon Oct 15 00:00:00 EDT 2012
Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans.
Journal of immunology (Baltimore, Md. : 1950)
Cuda CM,Li S,Liang S,Yin Y,Potula HH,Xu Z,Sengupta M,Chen Y,Butfiloski E,Baker H,Chang LJ,Dozmorov I,Sobel ES,Morel L
Sun Jan 15 00:00:00 EST 2012
Antigen-specific transfer of functional programmed death ligand 1 from human APCs onto CD8+ T cells via trogocytosis.
Journal of immunology (Baltimore, Md. : 1950)
Gary R,Voelkl S,Palmisano R,Ullrich E,Bosch JJ,Mackensen A
Sun Jan 15 00:00:00 EST 2012
Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.
Journal of immunology (Baltimore, Md. : 1950)
Pham D,Vincentz JW,Firulli AB,Kaplan MH
Sun Jul 15 00:00:00 EDT 2012
Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Mukherjee S,Giamberardino C,Thomas J,Evans K,Goto H,Ledford JG,Hsia B,Pastva AM,Wright JR
Wed Feb 01 00:00:00 EST 2012
Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway.
Journal of immunology (Baltimore, Md. : 1950)
Zhao YG,Wang Y,Guo Z,Gu AD,Dan HC,Baldwin AS,Hao W,Wan YY
Thu Nov 01 00:00:00 EDT 2012
Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling.
Journal of immunology (Baltimore, Md. : 1950)
Zhi L,Ustyugova IV,Chen X,Zhang Q,Wu MX
Wed Aug 15 00:00:00 EDT 2012
Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.
Journal of immunology (Baltimore, Md. : 1950)
Zizzo G,Hilliard BA,Monestier M,Cohen PL
Mon Oct 01 00:00:00 EDT 2012
Expression of Helios in peripherally induced Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Gottschalk RA,Corse E,Allison JP
Wed Feb 01 00:00:00 EST 2012
Mouse CD11b+Gr-1+ myeloid cells can promote Th17 cell differentiation and experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Yi H,Guo C,Yu X,Zuo D,Wang XY
Thu Nov 01 00:00:00 EDT 2012
Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-β1 signaling pathway.
Journal of immunology (Baltimore, Md. : 1950)
Ye XZ,Xu SL,Xin YH,Yu SC,Ping YF,Chen L,Xiao HL,Wang B,Yi L,Wang QL,Jiang XF,Yang L,Zhang P,Qian C,Cui YH,Zhang X,Bian XW
Sun Jul 01 00:00:00 EDT 2012
Fyn promotes Th17 differentiation by regulating the kinetics of RORγt and Foxp3 expression.
Journal of immunology (Baltimore, Md. : 1950)
Ueda A,Zhou L,Stein PL
Fri Jun 01 00:00:00 EDT 2012
Surfactant protein A modulates induction of regulatory T cells via TGF-β.
Journal of immunology (Baltimore, Md. : 1950)
Mukherjee S,Giamberardino C,Thomas JM,Gowdy K,Pastva AM,Wright JR
Tue May 01 00:00:00 EDT 2012
Role of macrophage migration inhibitory factor in the regulatory T cell response of tumor-bearing mice.
Journal of immunology (Baltimore, Md. : 1950)
Choi S,Kim HR,Leng L,Kang I,Jorgensen WL,Cho CS,Bucala R,Kim WU
Mon Oct 15 00:00:00 EDT 2012
Resolution of immune response by recombinant transforming growth factor-beta (rTGF-β) during influenza A virus infection.
The Indian journal of medical research
Srivastava V,Khanna M,Sharma S,Kumar B
Mon Oct 01 00:00:00 EDT 2012
MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F.
Molecular and cellular biology
Jurmeister S,Baumann M,Balwierz A,Keklikoglou I,Ward A,Uhlmann S,Zhang JD,Wiemann S,Sahin Ö
Wed Feb 01 00:00:00 EST 2012
Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice.
Evidence-based complementary and alternative medicine : eCAM
Wang X,Kageyama-Yahara N,Hayashi S,Yamamoto T,Kadowaki M
Thu Aug 23 00:00:00 EDT 2012
Cholesteatoma-associated fibroblasts modulate epithelial growth and differentiation through KGF/FGF7 secretion.
Histochemistry and cell biology
Raffa S,Leone L,Scrofani C,Monini S,Torrisi MR,Barbara M
Wed Aug 01 00:00:00 EDT 2012
SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ.
PloS one
Madireddi S,Schabowsky RH,Srivastava AK,Sharma RK,Yolcu ES,Shirwan H
Tue Feb 19 00:00:00 EST 2013
Response gene to complement-32 enhances metastatic phenotype by mediating transforming growth factor beta-induced epithelial-mesenchymal transition in human pancreatic cancer cell line BxPC-3.
Journal of experimental & clinical cancer research : CR
Zhu L,Qin H,Li PY,Xu SN,Pang HF,Zhao HZ,Li DM,Zhao Q
Thu Mar 29 00:00:00 EDT 2012
Spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via TLR9-dependent crosstalk with myeloid dendritic cells.
PloS one
Jounai K,Ikado K,Sugimura T,Ano Y,Braun J,Fujiwara D
Wed Oct 17 00:00:00 EDT 2012
A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo.
PloS one
Kunisawa J,Hashimoto E,Ishikawa I,Kiyono H
Fri Jun 29 00:00:00 EDT 2012
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling.
The Journal of biological chemistry
Verma NK,Dempsey E,Long A,Davies A,Barry SP,Fallon PG,Volkov Y,Kelleher D
Fri Aug 03 00:00:00 EDT 2012
TGFβ signaling plays a critical role in promoting alternative macrophage activation.
BMC immunology
Gong D,Shi W,Yi SJ,Chen H,Groffen J,Heisterkamp N
Fri Jun 15 00:00:00 EDT 2012
Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics.
PloS one
Danova-Alt R,Heider A,Egger D,Cross M,Alt R
Tue Aug 07 00:00:00 EDT 2012
Selective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model.
The Journal of biological chemistry
Li Z,Liu WH,Han S,Peng BW,Yin J,Wu YL,He XH,Li WX
Fri Aug 24 00:00:00 EDT 2012
Dynamic regulation of Tgf-B signaling by Tif1γ: a computational approach.
PloS one
Andrieux G,Fattet L,Le Borgne M,Rimokh R,Théret N
Fri Jun 29 00:00:00 EDT 2012
Chronic nerve growth factor exposure increases apoptosis in a model of in vitro induced conjunctival myofibroblasts.
PloS one
Micera A,Puxeddu I,Balzamino BO,Bonini S,Levi-Schaffer F
Thu Apr 04 00:00:00 EDT 2013
Coated pit-mediated endocytosis of the type I transforming growth factor-β (TGF-β) receptor depends on a di-leucine family signal and is not required for signaling.
The Journal of biological chemistry
Shapira KE,Gross A,Ehrlich M,Henis YI
Fri Aug 03 00:00:00 EDT 2012
HILI inhibits TGF-β signaling by interacting with Hsp90 and promoting TβR degradation.
PloS one
Zhang K,Lu Y,Yang P,Li C,Sun H,Tao D,Liu Y,Zhang S,Ma Y
Thu Jan 10 00:00:00 EST 2013
TGFβ signalling plays an important role in IL4-induced alternative activation of microglia.
Journal of neuroinflammation
Zhou X,Spittau B,Krieglstein K
Tue Sep 04 00:00:00 EDT 2012
TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death.
Cell death & disease
Chang JY,Chiang MF,Lin SR,Lee MH,He H,Chou PY,Chen SJ,Chen YA,Yang LY,Lai FJ,Hsieh CC,Hsieh TH,Sheu HM,Sze CI,Chang NS
Thu Apr 26 00:00:00 EDT 2012
TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death.
Cell death & disease
Chang JY,Chiang MF,Lin SR,Lee MH,He H,Chou PY,Chen SJ,Chen YA,Yang LY,Lai FJ,Hsieh CC,Hsieh TH,Sheu HM,Sze CI,Chang NS
Thu Apr 26 00:00:00 EDT 2012
TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death.
Cell death & disease
Chang JY,Chiang MF,Lin SR,Lee MH,He H,Chou PY,Chen SJ,Chen YA,Yang LY,Lai FJ,Hsieh CC,Hsieh TH,Sheu HM,Sze CI,Chang NS
Thu Apr 26 00:00:00 EDT 2012
Activin A promotes neuronal differentiation of cerebrocortical neural progenitor cells.
PloS one
Rodríguez-Martínez G,Molina-Hernández A,Velasco I
Tue Jan 29 00:00:00 EST 2013
Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.
PloS one
Koguchi Y,Buenafe AC,Thauland TJ,Gardell JL,Bivins-Smith ER,Jacoby DB,Slifka MK,Parker DC
Fri Jun 29 00:00:00 EDT 2012
Evaluation of cell proliferation, apoptosis, and DNA-repair genes as potential biomarkers for ethanol-induced CNS alterations.
BMC neuroscience
Hicks SD,Lewis L,Ritchie J,Burke P,Abdul-Malak Y,Adackapara N,Canfield K,Shwarts E,Gentile K,Meszaros ZS,Middleton FA
Thu Oct 25 00:00:00 EDT 2012
Human amniotic fluid stem cell injection therapy for urethral sphincter regeneration in an animal model.
BMC medicine
Kim BS,Chun SY,Lee JK,Lim HJ,Bae JS,Chung HY,Atala A,Soker S,Yoo JJ,Kwon TG
Tue Aug 21 00:00:00 EDT 2012
Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1.
PloS one
Boivin WA,Shackleford M,Vanden Hoek A,Zhao H,Hackett TL,Knight DA,Granville DJ
Tue Aug 28 00:00:00 EDT 2012
Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex.
PloS one
Bastea LI,Döppler H,Balogun B,Storz P
Mon Jun 04 00:00:00 EDT 2012
Differential expression of surface markers in mouse bone marrow mesenchymal stromal cell subpopulations with distinct lineage commitment.
PloS one
Rostovskaya M,Anastassiadis K
Tue Jun 11 00:00:00 EDT 2013
One-step derivation of mesenchymal stem cell (MSC)-like cells from human pluripotent stem cells on a fibrillar collagen coating.
PloS one
Liu Y,Goldberg AJ,Dennis JE,Gronowicz GA,Kuhn LT
Fri Aug 03 00:00:00 EDT 2012
Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1.
Journal of neuroinflammation
Huang XQ,Zhang XY,Wang XR,Yu SY,Fang SH,Lu YB,Zhang WP,Wei EQ
Tue Jun 26 00:00:00 EDT 2012
Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing.
PloS one
Shi L,Chang Y,Yang Y,Zhang Y,Yu FS,Wu X
Fri Jun 29 00:00:00 EDT 2012
A transcriptionally active pRb-E2F1-P/CAF signaling pathway is central to TGFβ-mediated apoptosis.
Cell death & disease
Korah J,Falah N,Lacerte A,Lebrun JJ
Thu Oct 11 00:00:00 EDT 2012
A transcriptionally active pRb-E2F1-P/CAF signaling pathway is central to TGFβ-mediated apoptosis.
Cell death & disease
Korah J,Falah N,Lacerte A,Lebrun JJ
Thu Oct 11 00:00:00 EDT 2012
Small molecule-assisted, line-independent maintenance of human pluripotent stem cells in defined conditions.
PloS one
Frank S,Zhang M,Schöler HR,Greber B
100-21C was used in Cell Culture to imply that using supportive factors at minimal concentrations may still promote robust self-renewal and preserve pluripotency of hPSCs.
Mon Jan 14 00:00:00 EST 2013
A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis.
PloS one
Noda S,Asano Y,Akamata K,Aozasa N,Taniguchi T,Takahashi T,Ichimura Y,Toyama T,Sumida H,Yanaba K,Tada Y,Sugaya M,Kadono T,Sato S
Mon Aug 27 00:00:00 EDT 2012
FcεR1-mediated mast cell reactivity is amplified through prolonged Toll-like receptor-ligand treatment.
PloS one
Saluja R,Delin I,Nilsson GP,Adner M
Wed Jan 16 00:00:00 EST 2013
Protons sensitize epithelial cells to mesenchymal transition.
PloS one
Wang M,Hada M,Saha J,Sridharan DM,Pluth JM,Cucinotta FA
Wed Nov 28 00:00:00 EST 2012
Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition.
PloS one
Liu Z,Zhang B,Liu K,Ding Z,Hu X
Tue Apr 02 00:00:00 EDT 2013
Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition.
PloS one
Liu Z,Zhang B,Liu K,Ding Z,Hu X
Tue Apr 02 00:00:00 EDT 2013
Isolation and characterization of two kinds of stem cells from the same human skin back sample with therapeutic potential in spinal cord injury.
PloS one
Zong Z,Li N,Ran X,Su Y,Shen Y,Shi CM,Cheng TM
Mon May 20 00:00:00 EDT 2013
The changes of Th17 cells and the related cytokines in the progression of human colorectal cancers.
BMC cancer
Wang J,Xu K,Wu J,Luo C,Li Y,Wu X,Gao H,Feng G,Yuan BZ
Fri Sep 21 00:00:00 EDT 2012
Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.
PloS one
Tsuda K,Yamanaka K,Kitagawa H,Akeda T,Naka M,Niwa K,Nakanishi T,Kakeda M,Gabazza EC,Mizutani H
Fri Aug 03 00:00:00 EDT 2012
Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor β1 (TGF-β1) in epithelial cell lines.
The Journal of biological chemistry
Xu Q,Isaji T,Lu Y,Gu W,Kondo M,Fukuda T,Du Y,Gu J
Fri May 11 00:00:00 EDT 2012
Transforming growth factor β1 inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy?
BMC medicine
Ehnert S,Zhao J,Pscherer S,Freude T,Dooley S,Kolk A,Stöckle U,Nussler AK,Hube R
Fri Sep 07 00:00:00 EDT 2012
RNA-seq analysis reveals different dynamics of differentiation of human dermis- and adipose-derived stromal stem cells.
PloS one
Jääger K,Islam S,Zajac P,Linnarsson S,Neuman T
Wed Dec 12 00:00:00 EST 2012
Calpain activity is essential in skin wound healing and contributes to scar formation.
PloS one
Nassar D,Letavernier E,Baud L,Aractingi S,Khosrotehrani K
Tue Jan 08 00:00:00 EST 2013
Differential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signaling.
PloS one
Hirschhorn T,Barizilay L,Smorodinsky NI,Ehrlich M
Tue Jan 29 00:00:00 EST 2013
EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.
PLoS genetics
Morel AP,Hinkal GW,Thomas C,Fauvet F,Courtois-Cox S,Wierinckx A,Devouassoux-Shisheboran M,Treilleux I,Tissier A,Gras B,Pourchet J,Puisieux I,Browne GJ,Spicer DB,Lachuer J,Ansieau S,Puisieux A
Wed Sep 26 00:00:00 EDT 2012
MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1.
PloS one
Yao R,Ma YL,Liang W,Li HH,Ma ZJ,Yu X,Liao YH
Thu Mar 28 00:00:00 EDT 2013
Optimal isolation of functional Foxp3+ induced regulatory T cells using DEREG mice.
PloS one
Baru AM,Untucht C,Ganesh V,Hesse C,Mayer CT,Sparwasser T
Thu Feb 14 00:00:00 EST 2013
SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.
The Journal of biological chemistry
Kawamura I,Maeda S,Imamura K,Setoguchi T,Yokouchi M,Ishidou Y,Komiya S
Fri Aug 17 00:00:00 EDT 2012
TGF-β inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: a dominant role for Smad-2.
Biochimica et biophysica acta
Michael DR,Salter RC,Ramji DP
Mon Oct 01 00:00:00 EDT 2012
Regulation of MMP-9 by a WIN-binding site in the monocyte-macrophage system independent from cannabinoid receptors.
PloS one
Tauber S,Paulsen K,Wolf S,Synwoldt P,Pahl A,Schneider-Stock R,Ullrich O
Tue Apr 23 00:00:00 EDT 2013
Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation.
The Journal of biological chemistry
Choi JC,Wu W,Muchir A,Iwata S,Homma S,Worman HJ
Fri Nov 23 00:00:00 EST 2012
Rapamycin ameliorates kidney fibrosis by inhibiting the activation of mTOR signaling in interstitial macrophages and myofibroblasts.
PloS one
Chen G,Chen H,Wang C,Peng Y,Sun L,Liu H,Liu F
Fri Aug 03 00:00:00 EDT 2012
De novo DNA methylation is required to restrict T helper lineage plasticity.
The Journal of biological chemistry
Thomas RM,Gamper CJ,Ladle BH,Powell JD,Wells AD
Fri Jun 29 00:00:00 EDT 2012
Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects.
PloS one
Garcia-Gomez A,Ocio EM,Crusoe E,Santamaria C,Hernández-Campo P,Blanco JF,Sanchez-Guijo FM,Hernández-Iglesias T,Briñón JG,Fisac-Herrero RM,Lee FY,Pandiella A,San Miguel JF,Garayoa M
Mon Sep 10 00:00:00 EDT 2012
TGF-β-operated growth inhibition and translineage commitment into smooth muscle cells of periodontal ligament-derived endothelial progenitor cells through Smad- and p38 MAPK-dependent signals.
International journal of biological sciences
Yoshida M,Okubo N,Chosa N,Hasegawa T,Ibi M,Kamo M,Kyakumoto S,Ishisaki A
Wed Nov 28 00:00:00 EST 2012
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
Cell
Dang EV,Barbi J,Yang HY,Jinasena D,Yu H,Zheng Y,Bordman Z,Fu J,Kim Y,Yen HR,Luo W,Zeller K,Shimoda L,Topalian SL,Semenza GL,Dang CV,Pardoll DM,Pan F
Fri Sep 02 00:00:00 EDT 2011
TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation.
Nature immunology
Beal AM,Ramos-Hernández N,Riling CR,Nowelsky EA,Oliver PM
Sun Nov 13 00:00:00 EST 2011
Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation.
Blood
Jiang S,Li C,Olive V,Lykken E,Feng F,Sevilla J,Wan Y,He L,Li QJ
Thu Nov 17 00:00:00 EST 2011
Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis.
Blood
Noubade R,Krementsov DN,Del Rio R,Thornton T,Nagaleekar V,Saligrama N,Spitzack A,Spach K,Sabio G,Davis RJ,Rincon M,Teuscher C
Thu Sep 22 00:00:00 EDT 2011
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.
The Journal of clinical investigation
Barrow AD,Raynal N,Andersen TL,Slatter DA,Bihan D,Pugh N,Cella M,Kim T,Rho J,Negishi-Koga T,Delaisse JM,Takayanagi H,Lorenzo J,Colonna M,Farndale RW,Choi Y,Trowsdale J
Thu Sep 01 00:00:00 EDT 2011
NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice.
The Journal of clinical investigation
Murray SE,Polesso F,Rowe AM,Basak S,Koguchi Y,Toren KG,Hoffmann A,Parker DC
Thu Dec 01 00:00:00 EST 2011
Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells.
Proceedings of the National Academy of Sciences of the United States of America
Baschant U,Frappart L,Rauchhaus U,Bruns L,Reichardt HM,Kamradt T,Bräuer R,Tuckermann JP
Tue Nov 29 00:00:00 EST 2011
EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation.
The Journal of cell biology
Danussi C,Petrucco A,Wassermann B,Pivetta E,Modica TM,Del Bel Belluz L,Colombatti A,Spessotto P
Mon Oct 03 00:00:00 EDT 2011
Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements.
Journal of immunology (Baltimore, Md. : 1950)
Dunnick WA,Shi J,Zerbato JM,Fontaine CA,Collins JT
Tue Nov 01 00:00:00 EDT 2011
Inducible CD4+LAP+Foxp3- regulatory T cells suppress allergic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Duan W,So T,Mehta AK,Choi H,Croft M
Thu Dec 15 00:00:00 EST 2011
Retinal self-antigen induces a predominantly Th1 effector response in Axl and Mertk double-knockout mice.
Journal of immunology (Baltimore, Md. : 1950)
Ye F,Han L,Lu Q,Dong W,Chen Z,Shao H,Kaplan HJ,Li Q,Lu Q
Sat Oct 15 00:00:00 EDT 2011
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N
Thu Dec 15 00:00:00 EST 2011
Ex vivo IL-1 receptor type I expression in human CD4+ T cells identifies an early intermediate in the differentiation of Th17 from FOXP3+ naive regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Raffin C,Raimbaud I,Valmori D,Ayyoub M
Tue Nov 15 00:00:00 EST 2011
Sensitivity and resistance to regulation by IL-4 during Th17 maturation.
Journal of immunology (Baltimore, Md. : 1950)
Cooney LA,Towery K,Endres J,Fox DA
Tue Nov 01 00:00:00 EDT 2011
A p53 defect sensitizes various stages of B cell development to lymphomagenesis in mice carrying an IgH 3' regulatory region-driven c-myc transgene.
Journal of immunology (Baltimore, Md. : 1950)
Fiancette R,Rouaud P,Vincent-Fabert C,Laffleur B,Magnone V,Cogné M,Denizot Y
Thu Dec 01 00:00:00 EST 2011
Platelet-activating factor induces Th17 cell differentiation.
Mediators of inflammation
Drolet AM,Thivierge M,Turcotte S,Hanna D,Maynard B,Stankovà J,Rola-Pleszczynski M
Tue May 15 00:00:00 EDT 2012
Regenerative therapy and cancer: in vitro and in vivo studies of the interaction between adipose-derived stem cells and breast cancer cells from clinical isolates.
Tissue engineering. Part A
Zimmerlin L,Donnenberg AD,Rubin JP,Basse P,Landreneau RJ,Donnenberg VS
100-21C was used in Cell Culture to investigate the use of adipose-derived stem cells for tumorigenesis of metastatic breast cancer isolates.
Sat Jan 01 00:00:00 EST 2011
[Survey on the awareness of community pharmacists about raising pharmaceutical questions regarding prescriptions issued by physicians].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Shikamura Y,Takahashi J,Oyama A,Negishi K,Ijyuin K,Kamimura N,Aoyama T
Fri Feb 24 00:00:00 EST 2012
Fascin protein is critical for transforming growth factor β protein-induced invasion and filopodia formation in spindle-shaped tumor cells.
The Journal of biological chemistry
Sun J,He H,Xiong Y,Lu S,Shen J,Cheng A,Chang WC,Hou MF,Lancaster JM,Kim M,Yang S
Fri Nov 11 00:00:00 EST 2011
NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering the MMP2/TIMP2 ratio in rats.
PloS one
Yang J,Zheng J,Wu L,Shi M,Zhang H,Wang X,Xia N,Wang D,Liu X,Yao L,Li Y,Dou K
Mon Mar 26 00:00:00 EDT 2012
NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering the MMP2/TIMP2 ratio in rats.
PloS one
Yang J,Zheng J,Wu L,Shi M,Zhang H,Wang X,Xia N,Wang D,Liu X,Yao L,Li Y,Dou K
Mon Mar 26 00:00:00 EDT 2012
Tension-compression loading with chemical stimulation results in additive increases to functional properties of anatomic meniscal constructs.
PloS one
Huey DJ,Athanasiou KA
Thu May 03 00:00:00 EDT 2012
Chemokine (C-C motif) ligand 2 mediates direct and indirect fibrotic responses in human and murine cultured fibrocytes.
Fibrogenesis & tissue repair
Ekert JE,Murray LA,Das AM,Sheng H,Giles-Komar J,Rycyzyn MA
Wed Oct 19 00:00:00 EDT 2011
Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis.
PloS one
Bhattacharyya S,Sargent JL,Du P,Lin S,Tourtellotte WG,Takehara K,Whitfield ML,Varga J
Fri Feb 03 00:00:00 EST 2012
Profibrotic potential of prominin-1+ epithelial progenitor cells in pulmonary fibrosis.
Respiratory research
Blyszczuk P,Germano D,Stein S,Moch H,Matter CM,Beck-Schimmer B,Lüscher TF,Eriksson U,Kania G
Mon Sep 26 00:00:00 EDT 2011
Enhanced activity of transforming growth factor β1 (TGF-β1) bound to cartilage oligomeric matrix protein.
The Journal of biological chemistry
Haudenschild DR,Hong E,Yik JH,Chromy B,Mörgelin M,Snow KD,Acharya C,Takada Y,Di Cesare PE
Fri Dec 16 00:00:00 EST 2011
Critical role of TCF-1 in repression of the IL-17 gene.
PloS one
Ma J,Wang R,Fang X,Ding Y,Sun Z
Tue Feb 28 00:00:00 EST 2012
Homing and reparative effect of intra-articular injection of autologus mesenchymal stem cells in osteoarthritic animal model.
BMC musculoskeletal disorders
Mokbel AN,El Tookhy OS,Shamaa AA,Rashed LA,Sabry D,El Sayed AM
Tue Nov 15 00:00:00 EST 2011
TGF-β suppresses β-catenin-dependent tolerogenic activation program in dendritic cells.
PloS one
Vander Lugt B,Beck ZT,Fuhlbrigge RC,Hacohen N,Campbell JJ,Boes M
Mon Oct 17 00:00:00 EDT 2011
Differential growth factor adsorption to calvarial osteoblast-secreted extracellular matrices instructs osteoblastic behavior.
PloS one
Bhat A,Boyadjiev SA,Senders CW,Leach JK
Mon Feb 13 00:00:00 EST 2012
Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders.
Proceedings of the National Academy of Sciences of the United States of America
Kwon HK,Lee CG,So JS,Chae CS,Hwang JS,Sahoo A,Nam JH,Rhee JH,Hwang KC,Im SH
Tue Feb 02 00:00:00 EST 2010
FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Tartar DM,VanMorlan AM,Wan X,Guloglu FB,Jain R,Haymaker CL,Ellis JS,Hoeman CM,Cascio JA,Dhakal M,Oukka M,Zaghouani H
Thu Apr 01 00:00:00 EDT 2010
De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Wang J,Huizinga TW,Toes RE
Tue Sep 15 00:00:00 EDT 2009
Effect of initial seeding density on human umbilical cord mesenchymal stromal cells for fibrocartilage tissue engineering.
Tissue engineering. Part A
Wang L,Seshareddy K,Weiss ML,Detamore MS
Fri May 01 00:00:00 EDT 2009
Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology.
Nature protocols
Smits AM,van Vliet P,Metz CH,Korfage T,Sluijter JP,Doevendans PA,Goumans MJ
Wed Apr 01 00:00:00 EDT 2009
Galectin-3 regulates myofibroblast activation and hepatic fibrosis.
Proceedings of the National Academy of Sciences of the United States of America
Henderson NC,Mackinnon AC,Farnworth SL,Poirier F,Russo FP,Iredale JP,Haslett C,Simpson KJ,Sethi T
Tue Mar 28 00:00:00 EST 2006
Inhibins differentially antagonize activin and bone morphogenetic protein action in a mouse adrenocortical cell line.
Endocrinology
Farnworth PG,Stanton PG,Wang Y,Escalona R,Findlay JK,Ooi GT
Sat Jul 01 00:00:00 EDT 2006
Flt3 ligand promotes the generation of a distinct CD34(+) human natural killer cell progenitor that responds to interleukin-15.
Blood
Yu H,Fehniger TA,Fuchshuber P,Thiel KS,Vivier E,Carson WE,Caligiuri MA
Sun Nov 15 00:00:00 EST 1998
