Product References
Differentiation of Human Induced Pluripotent Stem Cells (iPSCs)-derived Mesenchymal Progenitors into Chondrocytes.
Bio-protocol
Khan NM,Diaz-Hernandez ME,Drissi H
100-36E was used in Cell Culture to describe the detailed procedure for successful derivation of mesenchymal progenitor population from human iPSCs, which are then differentiated into chondrocytes using high-density culture conditions by stimulating with bone morphogenetic protein-2 (BMP-2) or transforming growth factor beta-3 (TGFβ-3).
Sun Nov 05 00:00:00 EDT 2023
Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment.
Movement disorders : official journal of the Movement Disorder Society
Jarazo J,Barmpa K,Modamio J,Saraiva C,Sabaté-Soler S,Rosety I,Griesbeck A,Skwirblies F,Zaffaroni G,Smits LM,Su J,Arias-Fuenzalida J,Walter J,Gomez-Giro G,Monzel AS,Qing X,Vitali A,Cruciani G,Boussaad I,Brunelli F,Jäger C,Rakovic A,Li W,Yuan L,Berger E,Arena G,Bolognin S,Schmidt R,Schröder C,Antony PMA,Klein C,Krüger R,Seibler P,Schwamborn JC
100-36E was used in Cell Culture to investigate the effects of biallelic mutations in phosphatase and tensin homolog-induced putative kinase 1 on Parkinson's disease.
Sat Jan 01 00:00:00 EST 2022
Transposon-mediated glial cell line-derived neurotrophic factor overexpression in human adipose tissue-derived mesenchymal stromal cells: A potential approach for neuroregenerative medicine?
Journal of tissue engineering and regenerative medicine
Rasińska J,Klein C,Stahn L,Maidhof F,Pfeffer A,Schreyer S,Gossen M,Kurtz A,Steiner B,Hemmati-Sadeghi S
100-36E was used in In vitro experiments to achieve continuous in vitro overexpression of GDNF in immune-privileged human adipose tissue-derived mesenchymal stromal cells (GDNF-tASCs) using a non-viral Sleeping Beauty transposon.
Wed Jun 01 00:00:00 EDT 2022
Identifying the key genes regulating mesenchymal stem cells chondrogenic differentiation: an in vitro study.
BMC musculoskeletal disorders
Liang T,Li P,Liang A,Zhu Y,Qiu X,Qiu J,Peng Y,Huang D,Gao W,Gao B
100-36E was used in Cell Culture to suggest that these DEGs may have a complex effect on MSCs chondrogenesis both synergistically and solitarily.
Tue Nov 15 00:00:00 EST 2022
A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration.
Cell discovery
Jin Y,Liu Q,Chen P,Zhao S,Jiang W,Wang F,Li P,Zhang Y,Lu W,Zhong TP,Ma X,Wang X,Gartland A,Wang N,Shah KM,Zhang H,Cao X,Yang L,Liu M,Luo J
100-36E was used in In vitro experiments to demonstrate that EP4 can act as a promising therapeutic target for cartilage regeneration and the novel EP4 antagonist HL-43 has the clinical potential to be used for cartilage repair and regeneration.
Tue Mar 08 00:00:00 EST 2022
Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent.
International journal of molecular sciences
Shephard MT,Merkhan MM,Forsyth NR
100-36E was used in In vitro experiments to investigate human mesenchymal stem cell secretions in treatment therapies.
Sun Nov 06 00:00:00 EDT 2022
Batch Effects during Human Bone Marrow Stromal Cell Propagation Prevail Donor Variation and Culture Duration: Impact on Genotype, Phenotype and Function.
Cells
Brachtl G,Poupardin R,Hochmann S,Raninger A,Jürchott K,Streitz M,Schlickeiser S,Oeller M,Wolf M,Schallmoser K,Volk HD,Geissler S,Strunk D
100-36E was used in Cell Culture to demonstrate pronounced batch effects on BMSC transcriptome, phenotype and function due to serum factors, partly outcompeting donor variation after just one culture passage.
Thu Mar 10 00:00:00 EST 2022
Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses.
Cell research
He J,Yan J,Wang J,Zhao L,Xin Q,Zeng Y,Sun Y,Zhang H,Bai Z,Li Z,Ni Y,Gong Y,Li Y,He H,Bian Z,Lan Y,Ma C,Bian L,Zhu H,Liu B,Yue R
Thu Jul 01 00:00:00 EDT 2021
H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model.
Cancer cell
Haag D,Mack N,Benites Goncalves da Silva P,Statz B,Clark J,Tanabe K,Sharma T,Jäger N,Jones DTW,Kawauchi D,Wernig M,Pfister SM
Mon Mar 08 00:00:00 EST 2021
H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair.
Bone research
Shao R,Zhang Z,Xu Z,Ouyang H,Wang L,Ouyang H,Greenblatt M,Chen X,Zou W
Mon Jun 07 00:00:00 EDT 2021
Telomerase expression marks transitional growth-associated skeletal progenitor/stem cells.
Stem cells (Dayton, Ohio)
Carlone DL,Riba-Wolman RD,Deary LT,Tovaglieri A,Jiang L,Ambruzs DM,Mead BE,Shah MS,Lengner CJ,Jaenisch R,Breault DT
Mon Mar 01 00:00:00 EST 2021
Impairment of the Hif-1α regulatory pathway in Foxn1-deficient (Foxn1-/- ) mice affects the skin wound healing process.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Machcinska S,Kopcewicz M,Bukowska J,Walendzik K,Gawronska-Kozak B
Mon Feb 01 00:00:00 EST 2021
TGF-β isoforms inhibit hepatitis C virus propagation in transforming growth factor beta/SMAD protein signalling pathway dependent and independent manners.
Journal of cellular and molecular medicine
Zou LL,Li JR,Li H,Tan JL,Wang MX,Liu NN,Gao RM,Yan HY,Wang XK,Dong B,Li YH,Peng ZG
Thu Apr 01 00:00:00 EDT 2021
Characteristics of Mesenchymal Stem Cells Are Independent of Bone Marrow Storage Temperatures.
Stem cells international
Schrodi V,Neunaber C,Bundkirchen K,Ye W,Jiang Z,Petri M,Krettek C,Noack S
Sat Oct 30 00:00:00 EDT 2021
Cytological Effects of Serum Isolated from Polytraumatized Patients on Human Bone Marrow-Derived Mesenchymal Stem Cells.
Stem cells international
Long Y,Bundkirchen K,Gräff P,Krettek C,Noack S,Neunaber C
Sat Dec 11 00:00:00 EST 2021
Endocannabinoids increase human adipose stem cell differentiation and growth factor secretion in vitro.
Journal of tissue engineering and regenerative medicine
Ruhl T,Schneider PA,Kim BS,Beier JP
Fri Jan 01 00:00:00 EST 2021
Genipin crosslinked chitosan/PEO nanofibrous scaffolds exhibiting an improved microenvironment for the regeneration of articular cartilage.
Journal of biomaterials applications
Ching KY,Andriotis O,Sengers B,Stolz M
100-36E was used in Cell Culture to evaluate chitosan/PEO nanofibrous scaffolds for the regeneration of articular cartilage.
Wed Sep 01 00:00:00 EDT 2021
The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1.
Cell reports
Walter J,Bolognin S,Poovathingal SK,Magni S,Gérard D,Antony PMA,Nickels SL,Salamanca L,Berger E,Smits LM,Grzyb K,Perfeito R,Hoel F,Qing X,Ohnmacht J,Bertacchi M,Jarazo J,Ignac T,Monzel AS,Gonzalez-Cano L,Krüger R,Sauter T,Studer M,de Almeida LP,Tronstad KJ,Sinkkonen L,Skupin A,Schwamborn JC
Tue Oct 19 00:00:00 EDT 2021
Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats.
Nature communications
de Luzy IR,Law KCL,Moriarty N,Hunt CPJ,Durnall JC,Thompson LH,Nagy A,Parish CL
Thu May 27 00:00:00 EDT 2021
The effects of 3D culture on the expansion and maintenance of nucleus pulposus progenitor cell multipotency.
JOR spine
Guerrero J,Häckel S,Croft AS,Albers CE,Gantenbein B
Mon Mar 01 00:00:00 EST 2021
A Tendon-Specific Double Reporter Transgenic Mouse Enables Tracking Cell Lineage and Functions Alteration In Vitro and In Vivo.
International journal of molecular sciences
Chen R,Zhou X,Skutella T
100-36E was used in Cell Culture to investigate real time cell behaviour in mouse tendons with a double fluorescent reporter system in transgenic mice.
Sun Oct 17 00:00:00 EDT 2021
Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.
FEBS open bio
Fukusumi H,Togo K,Sumida M,Nakamori M,Obika S,Baba K,Shofuda T,Ito D,Okano H,Mochizuki H,Kanemura Y
Mon Feb 01 00:00:00 EST 2021
PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons.
Scientific reports
Brown SJ,Boussaad I,Jarazo J,Fitzgerald JC,Antony P,Keatinge M,Blechman J,Schwamborn JC,Krüger R,Placzek M,Bandmann O
Tue Mar 23 00:00:00 EDT 2021
Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate.
NPJ Regenerative medicine
Casanova MR,Osório H,Reis RL,Martins A,Neves NM
Fri Nov 19 00:00:00 EST 2021
Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates.
Cell discovery
Chen H,Xia K,Huang W,Li H,Wang C,Ma Y,Chen J,Luo P,Zheng S,Wang J,Wang Y,Dong L,Tan Z,Lai X,Mao FF,Li W,Liang X,Wang T,Xiang AP,Ke Q
Tue Aug 31 00:00:00 EDT 2021
The difficulty to model Huntington's disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells.
Scientific reports
Le Cann K,Foerster A,Rösseler C,Erickson A,Hautvast P,Giesselmann S,Pensold D,Kurth I,Rothermel M,Mattis VB,Zimmer-Bensch G,von Hörsten S,Denecke B,Clarner T,Meents J,Lampert A
Thu Mar 25 00:00:00 EDT 2021
Regulation of TGFβ Signalling by TRPV4 in Chondrocytes.
Cells
Woods S,Humphreys PA,Bates N,Richardson SA,Kuba SY,Brooks IR,Cain SA,Kimber SJ
100-36E was used in Cell Culture to study how TRPV4 and TGFβ signals are integrated to show that TRPV4 modulation of TGFβ signalling represents an important pathway linking mechanical signalling to tissue development and homeostasis.
Wed Mar 24 00:00:00 EDT 2021
Regulation of TGFβ Signalling by TRPV4 in Chondrocytes.
Cells
Woods S,Humphreys PA,Bates N,Richardson SA,Kuba SY,Brooks IR,Cain SA,Kimber SJ
100-36E was used in Cell Culture to study how TRPV4 and TGFβ signals are integrated to show that TRPV4 modulation of TGFβ signalling represents an important pathway linking mechanical signalling to tissue development and homeostasis.
Wed Mar 24 00:00:00 EDT 2021
The intracellular milieu of Parkinson's disease patient brain cells modulates alpha-synuclein protein aggregation.
Acta neuropathologica communications
Gustavsson N,Savchenko E,Klementieva O,Roybon L
100-36E was used in Cell Culture to suggest that changes in cellular milieu induced by patient genomes trigger structural changes of aSYN potentially leading to the formation of strains having different structures, properties and seeding propensities.
Thu Sep 16 00:00:00 EDT 2021
Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer.
iScience
Delaine-Smith RM,Maniati E,Malacrida B,Nichols S,Roozitalab R,Jones RR,Lecker LSM,Pearce OMT,Knight MM,Balkwill FR
Fri Jun 25 00:00:00 EDT 2021
α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology.
Cell reports
Stykel MG,Humphries KM,Kamski-Hennekam E,Buchner-Duby B,Porte-Trachsel N,Ryan T,Coackley CL,Bamm VV,Harauz G,Ryan SD
Tue May 11 00:00:00 EDT 2021
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity.
Nature genetics
Kinker GS,Greenwald AC,Tal R,Orlova Z,Cuoco MS,McFarland JM,Warren A,Rodman C,Roth JA,Bender SA,Kumar B,Rocco JW,Fernandes PACM,Mader CC,Keren-Shaul H,Plotnikov A,Barr H,Tsherniak A,Rozenblatt-Rosen O,Krizhanovsky V,Puram SV,Regev A,Tirosh I
Sun Nov 01 00:00:00 EDT 2020
T-cell expression of Bruton's tyrosine kinase promotes autoreactive T-cell activation and exacerbates aplastic anemia.
Cellular & molecular immunology
Xia S,Liu X,Cao X,Xu S
Thu Oct 01 00:00:00 EDT 2020
Synergistic Effects of Kartogenin and Transforming Growth Factor-β3 on Chondrogenesis of Human Umbilical Cord Mesenchymal Stem Cells In Vitro.
Orthopaedic surgery
Zhao Y,Teng B,Sun X,Dong Y,Wang S,Hu Y,Wang Z,Ma X,Yang Q
Mon Jun 01 00:00:00 EDT 2020
TGF β-1 and WNT Signaling Pathways Collaboration Associated with Cochlear Implantation Trauma-Induced Fibrosis.
Anatomical record (Hoboken, N.J. : 2007)
Bas E,Anwar MR,Van De Water TR
100-36E was used in Tissue/organ culture to show that in light of our observations from the current study, manipulation of the WNT pathway by gene therapy techniques in the pathological ear seems a very complex process with an increased risk of inducing excessive fibrosis thereby compromising the efficacy of implant function.
Sun Mar 01 00:00:00 EST 2020
AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma.
Nature communications
Yao CD,Haensel D,Gaddam S,Patel T,Atwood SX,Sarin KY,Whitson RJ,McKellar S,Shankar G,Aasi S,Rieger K,Oro AE
Thu Oct 08 00:00:00 EDT 2020
In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets.
Scientific reports
Vermilyea SC,Babinski A,Tran N,To S,Guthrie S,Kluss JH,Schmidt JK,Wiepz GJ,Meyer MG,Murphy ME,Cookson MR,Emborg ME,Golos TG
Wed Feb 26 00:00:00 EST 2020
A circular RNA map for human induced pluripotent stem cells of foetal origin.
EBioMedicine
Barilani M,Cherubini A,Peli V,Polveraccio F,Bollati V,Guffanti F,Del Gobbo A,Lavazza C,Giovanelli S,Elvassore N,Lazzari L
100-36E was used in Cell Culture to generate hiPSC from cord blood multipotent mesenchymal stromal cells (MSC-hiPSC) and compare them with F-hiPSC.
Wed Jul 01 00:00:00 EDT 2020
Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses.
Nature communications
Evans RDR,Antonelou M,Sathiananthamoorthy S,Rega M,Henderson S,Ceron-Gutierrez L,Barcenas-Morales G,Müller CA,Doffinger R,Walsh SB,Salama AD
100-36E was used in In vitro experiments to investigate immunity in patients with inherited salt-losing tubulopathies (SLT).
Mon Aug 31 00:00:00 EDT 2020
Red panda: a novel method for detecting variants in single-cell RNA sequencing.
BMC genomics
Cornish A,Roychoudhury S,Sarma K,Pramanik S,Bhakat K,Dudley A,Mishra NK,Guda C
100-36E was used in Cell Culture to show that our Red Panda method provides a novel and improved mechanism to identify variants in scRNA-seq as compared to currently existing software.
Tue Dec 29 00:00:00 EST 2020
Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells.
Nature communications
Panagiotakopoulou V,Ivanyuk D,De Cicco S,Haq W,Arsić A,Yu C,Messelodi D,Oldrati M,Schöndorf DC,Perez MJ,Cassatella RP,Jakobi M,Schneiderhan-Marra N,Gasser T,Nikić-Spiegel I,Deleidi M
Wed Oct 14 00:00:00 EDT 2020
Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer.
The Journal of biological chemistry
Takahashi K,Akatsu Y,Podyma-Inoue KA,Matsumoto T,Takahashi H,Yoshimatsu Y,Koinuma D,Shirouzu M,Miyazono K,Watabe T
Fri Sep 04 00:00:00 EDT 2020
Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons.
Scientific reports
Schwartzentruber A,Boschian C,Lopes FM,Myszczynska MA,New EJ,Beyrath J,Smeitink J,Ferraiuolo L,Mortiboys H
Wed Sep 23 00:00:00 EDT 2020
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids.
eLife
Renner H,Grabos M,Becker KJ,Kagermeier TE,Wu J,Otto M,Peischard S,Zeuschner D,TsyTsyura Y,Disse P,Klingauf J,Leidel SA,Seebohm G,Schöler HR,Bruder JM
Tue Nov 03 00:00:00 EST 2020
Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease.
Cell stem cell
Gantner CW,de Luzy IR,Kauhausen JA,Moriarty N,Niclis JC,Bye CR,Penna V,Hunt CPJ,Ermine CM,Pouton CW,Kirik D,Thompson LH,Parish CL
100-36E was used in Cell Culture to demonstrate the potential of neurotrophic gene therapy strategies to improve hPSC graft outcomes.
Thu Apr 02 00:00:00 EDT 2020
Optogenetic Control of the BMP Signaling Pathway.
ACS synthetic biology
Humphreys PA,Woods S,Smith CA,Bates N,Cain SA,Lucas R,Kimber SJ
100-36E was used in In vitro experiments to demonstrate the utility of the optoBMP system in multiple human cell lines to initiate signal transduction through phosphorylation and nuclear translocation of SMAD1/5, leading to upregulation of BMP target genes including Inhibitors of DNA binding ID2 and ID4.
Fri Nov 20 00:00:00 EST 2020
Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β.
Immunity
Komuczki J,Tuzlak S,Friebel E,Hartwig T,Spath S,Rosenstiel P,Waisman A,Opitz L,Oukka M,Schreiner B,Pelczar P,Becher B
100-36E was used in In vitro experiments to investigate pathogenic lymphocyte in chronic inflammatory disease.
Tue May 21 00:00:00 EDT 2019
Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation.
The Journal of clinical investigation
Han Y,Feng H,Sun J,Liang X,Wang Z,Xing W,Dai Q,Yang Y,Han A,Wei Z,Bi Q,Ji H,Kang T,Zou W
Wed May 01 00:00:00 EDT 2019
Development of immunocompatible pluripotent stem cells via CRISPR-based human leukocyte antigen engineering.
Experimental & molecular medicine
Jang Y,Choi J,Park N,Kang J,Kim M,Kim Y,Ju JH
Mon Jan 07 00:00:00 EST 2019
Human Cartilage-Derived Progenitors Resist Terminal Differentiation and Require CXCR4 Activation to Successfully Bridge Meniscus Tissue Tears.
Stem cells (Dayton, Ohio)
Jayasuriya CT,Twomey-Kozak J,Newberry J,Desai S,Feltman P,Franco JR,Li N,Terek R,Ehrlich MG,Owens BD
Tue Jan 01 00:00:00 EST 2019
Human Cartilage-Derived Progenitors Resist Terminal Differentiation and Require CXCR4 Activation to Successfully Bridge Meniscus Tissue Tears.
Stem cells (Dayton, Ohio)
Jayasuriya CT,Twomey-Kozak J,Newberry J,Desai S,Feltman P,Franco JR,Li N,Terek R,Ehrlich MG,Owens BD
Tue Jan 01 00:00:00 EST 2019
Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.
Journal of immunology (Baltimore, Md. : 1950)
Stephenson S,Care MA,Fan I,Zougman A,Westhead DR,Doody GM,Tooze RM
Fri Feb 15 00:00:00 EST 2019
TGF-β3 Induces Autophagic Activity by Increasing ROS Generation in a NOX4-Dependent Pathway.
Mediators of inflammation
Zhang Y,Tang HM,Liu CF,Yuan XF,Wang XY,Ma N,Xu GF,Wang SP,Deng J,Wang X
100-36E was used in In vitro experiments to study the exact mechanism of action on the cell-dependent relationship between ROS and autophagy.
Mon Jul 06 00:00:00 EDT 2020
BDNF-overexpressing human mesenchymal stem cells mediate increased neuronal protection in vitro.
Journal of neuroscience research
Scheper V,Schwieger J,Hamm A,Lenarz T,Hoffmann A
Fri Nov 01 00:00:00 EDT 2019
Photopolymerizable gelatin and hyaluronic acid for stereolithographic 3D bioprinting of tissue-engineered cartilage.
Journal of biomedical materials research. Part B, Applied biomaterials
Lam T,Dehne T,Krüger JP,Hondke S,Endres M,Thomas A,Lauster R,Sittinger M,Kloke L
Fri Nov 01 00:00:00 EDT 2019
Myocardin ablation in a cardiac-renal rat model.
Scientific reports
Mittal A,Rana S,Sharma R,Kumar A,Prasad R,Raut SK,Sarkar S,Saikia UN,Bahl A,Dhandapany PS,Khullar M
Wed Apr 10 00:00:00 EDT 2019
3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Bolognin S,Fossépré M,Qing X,Jarazo J,Ščančar J,Moreno EL,Nickels SL,Wasner K,Ouzren N,Walter J,Grünewald A,Glaab E,Salamanca L,Fleming RMT,Antony PMA,Schwamborn JC
Wed Jan 09 00:00:00 EST 2019
A novel mechanism for the protection of embryonic stem cell derived tenocytes from inflammatory cytokine interleukin 1 beta.
Scientific reports
McClellan A,Evans R,Sze C,Kan S,Paterson Y,Guest D
Tue Feb 26 00:00:00 EST 2019
Automated microfluidic cell culture of stem cell derived dopaminergic neurons.
Scientific reports
Kane KIW,Moreno EL,Hachi S,Walter M,Jarazo J,Oliveira MAP,Hankemeier T,Vulto P,Schwamborn JC,Thoma M,Fleming RMT
Mon Feb 11 00:00:00 EST 2019
Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose-derived stem cells.
Journal of tissue engineering and regenerative medicine
Gonçalves AI,Berdecka D,Rodrigues MT,Eren AD,de Boer J,Reis RL,Gomes ME
100-36E was used in In vitro experiments to investigate antigenically-defined subsets of hASCs expressing markers related to tendon phenotype or associated with pluripotency that might be more prone to tenogenic differentiation, when compared to unsorted hASCs.
Sun Dec 01 00:00:00 EST 2019
Characterization of polydactyly chondrocytes and their use in cartilage engineering.
Scientific reports
Cavalli E,Levinson C,Hertl M,Broguiere N,Brück O,Mustjoki S,Gerstenberg A,Weber D,Salzmann G,Steinwachs M,Barreto G,Zenobi-Wong M
Tue Mar 12 00:00:00 EDT 2019
Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration.
Nature communications
Keller L,Pijnenburg L,Idoux-Gillet Y,Bornert F,Benameur L,Tabrizian M,Auvray P,Rosset P,María Gonzalo-Daganzo R,Gómez Barrena E,Gentile L,Benkirane-Jessel N
Tue May 14 00:00:00 EDT 2019
The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
The Journal of clinical investigation
Wang B,Joo JH,Mount R,Teubner BJW,Krenzer A,Ward AL,Ichhaporia VP,Adams EJ,Khoriaty R,Peters ST,Pruett-Miller SM,Zakharenko SS,Ginsburg D,Kundu M
Wed Aug 01 00:00:00 EDT 2018
Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells.
Experimental & molecular medicine
Kim JY,Lee JS,Hwang HS,Lee DR,Park CY,Jung SJ,You YR,Kim DS,Kim DW
Fri Apr 13 00:00:00 EDT 2018
Functional Profiling of Chondrogenically Induced Multipotent Stromal Cell Aggregates Reveals Transcriptomic and Emergent Morphological Phenotypes Predictive of Differentiation Capacity.
Stem cells translational medicine
Lam J,Bellayr IH,Marklein RA,Bauer SR,Puri RK,Sung KE
Sat Sep 01 00:00:00 EDT 2018
Differential Regulation of Human Bone Marrow Mesenchymal Stromal Cell Chondrogenesis by Hypoxia Inducible Factor-1α Hydroxylase Inhibitors.
Stem cells (Dayton, Ohio)
Taheem DK,Foyt DA,Loaiza S,Ferreira SA,Ilic D,Auner HW,Grigoriadis AE,Jell G,Gentleman E
Sat Sep 01 00:00:00 EDT 2018
Relative Contributions of B Cells and Dendritic Cells from Lupus-Prone Mice to CD4+ T Cell Polarization.
Journal of immunology (Baltimore, Md. : 1950)
Choi SC,Xu Z,Li W,Yang H,Roopenian DC,Morse HC,Morel L
Tue May 01 00:00:00 EDT 2018
Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease.
Stem cell reports
Wang YK,Zhu WW,Wu MH,Wu YH,Liu ZX,Liang LM,Sheng C,Hao J,Wang L,Li W,Zhou Q,Hu BY
Tue Jul 10 00:00:00 EDT 2018
Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures.
Scientific reports
Rieder B,Weihs AM,Weidinger A,Szwarc D,Nürnberger S,Redl H,Rünzler D,Huber-Gries C,Teuschl AH
Mon Nov 19 00:00:00 EST 2018
Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents.
Stem cells translational medicine
Niclis JC,Gantner CW,Alsanie WF,McDougall SJ,Bye CR,Elefanty AG,Stanley EG,Haynes JM,Pouton CW,Thompson LH,Parish CL
Wed Mar 01 00:00:00 EST 2017
Osteogenic Programming of Human Mesenchymal Stem Cells with Highly Efficient Intracellular Delivery of RUNX2.
Stem cells translational medicine
Thiagarajan L,Abu-Awwad HAM,Dixon JE
Fri Dec 01 00:00:00 EST 2017
Transplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone production.
Cell death & disease
Zhang M,Wang J,Deng C,Jiang MH,Feng X,Xia K,Li W,Lai X,Xiao H,Ge RS,Gao Y,Xiang AP
Thu Oct 12 00:00:00 EDT 2017
Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells.
Stem cell reports
Monzel AS,Smits LM,Hemmer K,Hachi S,Moreno EL,van Wuellen T,Jarazo J,Walter J,Brüggemann I,Boussaad I,Berger E,Fleming RMT,Bolognin S,Schwamborn JC
Tue May 09 00:00:00 EDT 2017
Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms.
mAbs
Bedinger D,Lao L,Khan S,Lee S,Takeuchi T,Mirza AM
100-36E was used in Surface Plasmon Resonance to study the number of antibodies that bind and neutralize various combinations of TGFβ1, 2 or 3 using fully human antibody phage display libraries.
Tue Dec 13 00:00:00 EST 2016
Fibroblast Growth Factor Ligand Dependent Proliferation and Chondrogenic Differentiation of Synovium-Derived Stem Cells and Concomitant Adaptation of Wnt/Mitogen-Activated Protein Kinase Signals.
Tissue engineering. Part A
Pizzute T,Li J,Zhang Y,Davis ME,Pei M
Mon Aug 01 00:00:00 EDT 2016
Intra-articular injection of synovial mesenchymal stem cells improves cartilage repair in a mouse injury model.
Scientific reports
Mak J,Jablonski CL,Leonard CA,Dunn JF,Raharjo E,Matyas JR,Biernaskie J,Krawetz RJ
Thu Mar 17 00:00:00 EDT 2016
Effects of rAAV-mediated FGF-2 gene transfer and overexpression upon the chondrogenic differentiation processes in human bone marrow aspirates.
Journal of experimental orthopaedics
Frisch J,Venkatesan JK,Rey-Rico A,Zawada AM,Schmitt G,Madry H,Cucchiarini M
Thu Dec 01 00:00:00 EST 2016
Effects of rAAV-mediated FGF-2 gene transfer and overexpression upon the chondrogenic differentiation processes in human bone marrow aspirates.
Journal of experimental orthopaedics
Frisch J,Venkatesan JK,Rey-Rico A,Zawada AM,Schmitt G,Madry H,Cucchiarini M
Thu Dec 01 00:00:00 EST 2016
Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
Scientific reports
Borgs L,Peyre E,Alix P,Hanon K,Grobarczyk B,Godin JD,Purnelle A,Krusy N,Maquet P,Lefebvre P,Seutin V,Malgrange B,Nguyen L
Mon Sep 19 00:00:00 EDT 2016
Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p.
Stem cells (Dayton, Ohio)
Barter MJ,Tselepi M,Gómez R,Woods S,Hui W,Smith GR,Shanley DP,Clark IM,Young DA
Sun Nov 01 00:00:00 EDT 2015
Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.
Scientific reports
Palm T,Bolognin S,Meiser J,Nickels S,Träger C,Meilenbrock RL,Brockhaus J,Schreitmüller M,Missler M,Schwamborn JC
Fri Nov 06 00:00:00 EST 2015
Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint.
Scientific reports
Li Y,El Mozen LA,Cai H,Fang W,Meng Q,Li J,Deng M,Long X
Fri Mar 06 00:00:00 EST 2015
TGF-ß isoforms in cancer: Immunohistochemical expression and Smad-pathway-activity-analysis in thirteen major tumor types with a critical appraisal of antibody specificity and immunohistochemistry assay validity.
Oncotarget
Riemenschneider MJ,Hirblinger M,Vollmann-Zwerenz A,Hau P,Proescholdt MA,Jaschinski F,Rothhammer-Hampl T,Wosikowski K,Janicot M,Leo E
100-36E was used in Sample Preparation (Western Blotting) to investigate the main TGF-ß signalling pathway across 13 different tumour types.
Tue Sep 29 00:00:00 EDT 2015
Neuroprotection and immunomodulation by xenografted human mesenchymal stem cells following spinal cord ventral root avulsion.
Scientific reports
Ribeiro TB,Duarte AS,Longhini AL,Pradella F,Farias AS,Luzo AC,Oliveira AL,Olalla Saad ST
Mon Nov 09 00:00:00 EST 2015
Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons.
Nature communications
Jiang H,Xu Z,Zhong P,Ren Y,Liang G,Schilling HA,Hu Z,Zhang Y,Wang X,Chen S,Yan Z,Feng J
Mon Dec 07 00:00:00 EST 2015
Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction.
Cell research
Jiang MH,Cai B,Tuo Y,Wang J,Zang ZJ,Tu X,Gao Y,Su Z,Li W,Li G,Zhang M,Jiao J,Wan Z,Deng C,Lahn BT,Xiang AP
Mon Dec 01 00:00:00 EST 2014
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
Proceedings of the National Academy of Sciences of the United States of America
Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA
Tue Mar 19 00:00:00 EDT 2013
Genetic stability of bone marrow-derived human mesenchymal stromal cells in the Quantum System.
Cytotherapy
Jones M,Varella-Garcia M,Skokan M,Bryce S,Schowinsky J,Peters R,Vang B,Brecheisen M,Startz T,Frank N,Nankervis B
100-36E was used in Cell Culture to determine the genetic stability of bone marrow-derived human mesenchymal stromal cells selected and produced with the Quantum Cell Expansion System.
Fri Nov 01 00:00:00 EDT 2013
Load regulates bone formation and Sclerostin expression through a TGFβ-dependent mechanism.
PloS one
Nguyen J,Tang SY,Nguyen D,Alliston T
Tue Jul 02 00:00:00 EDT 2013
Load regulates bone formation and Sclerostin expression through a TGFβ-dependent mechanism.
PloS one
Nguyen J,Tang SY,Nguyen D,Alliston T
Tue Jul 02 00:00:00 EDT 2013
Stem cells catalyze cartilage formation by neonatal articular chondrocytes in 3D biomimetic hydrogels.
Scientific reports
Lai JH,Kajiyama G,Smith RL,Maloney W,Yang F
Thu Dec 19 00:00:00 EST 2013
Stem cells catalyze cartilage formation by neonatal articular chondrocytes in 3D biomimetic hydrogels.
Scientific reports
Lai JH,Kajiyama G,Smith RL,Maloney W,Yang F
Thu Dec 19 00:00:00 EST 2013
ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.
Molecular biology of the cell
Allen JL,Cooke ME,Alliston T
100-36E was used in Cell Culture to explore the mechanisms by which cells integrate the physical and biochemical cues provided by ECM stiffness and TGFβ.
Sat Sep 01 00:00:00 EDT 2012
High glucose mediates endothelial-to-chondrocyte transition in human aortic endothelial cells.
Cardiovascular diabetology
Tang R,Gao M,Wu M,Liu H,Zhang X,Liu B
Sat Sep 22 00:00:00 EDT 2012
Synovial fluid progenitors expressing CD90+ from normal but not osteoarthritic joints undergo chondrogenic differentiation without micro-mass culture.
PloS one
Krawetz RJ,Wu YE,Martin L,Rattner JB,Matyas JR,Hart DA
Tue Feb 19 00:00:00 EST 2013
TGF-β-operated growth inhibition and translineage commitment into smooth muscle cells of periodontal ligament-derived endothelial progenitor cells through Smad- and p38 MAPK-dependent signals.
International journal of biological sciences
Yoshida M,Okubo N,Chosa N,Hasegawa T,Ibi M,Kamo M,Kyakumoto S,Ishisaki A
Wed Nov 28 00:00:00 EST 2012
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.
Nature communications
Devine MJ,Ryten M,Vodicka P,Thomson AJ,Burdon T,Houlden H,Cavaleri F,Nagano M,Drummond NJ,Taanman JW,Schapira AH,Gwinn K,Hardy J,Lewis PA,Kunath T
Tue Aug 23 00:00:00 EDT 2011
Isolation of mouse mesenchymal stem cells with normal ploidy from bone marrows by reducing oxidative stress in combination with extracellular matrix.
BMC cell biology
Fan G,Wen L,Li M,Li C,Luo B,Wang F,Zhou L,Liu L
Wed Jul 06 00:00:00 EDT 2011
Crosstalk between nuclear factor I-C and transforming growth factor-β1 signaling regulates odontoblast differentiation and homeostasis.
PloS one
Lee DS,Yoon WJ,Cho ES,Kim HJ,Gronostajski RM,Cho MI,Park JC
Mon Aug 27 00:00:00 EDT 2012
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.
Nature
Méndez-Ferrer S,Michurina TV,Ferraro F,Mazloom AR,Macarthur BD,Lira SA,Scadden DT,Ma'ayan A,Enikolopov GN,Frenette PS
Thu Aug 12 00:00:00 EDT 2010
Transforming growth factor beta promotes neuronal cell fate of mouse cortical and hippocampal progenitors in vitro and in vivo: identification of Nedd9 as an essential signaling component.
Cerebral cortex (New York, N.Y. : 1991)
Vogel T,Ahrens S,Büttner N,Krieglstein K
Mon Mar 01 00:00:00 EST 2010
A stem cell-based tool for small molecule screening in adipogenesis.
PloS one
Qin J,Li WQ,Zhang L,Chen F,Liang WH,Mao FF,Zhang XM,Lahn BT,Yu WH,Xiang AP
Mon Sep 27 00:00:00 EDT 2010
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Tran DQ,Andersson J,Wang R,Ramsey H,Unutmaz D,Shevach EM
Tue Aug 11 00:00:00 EDT 2009
