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Product Details
RP-8600
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Published species
Not Applicable
Expression System
E. coli
Amino acid sequence
MALDTNYCFR NLEENCCVRP LYIDFRQDLG WKWVHEPKGY YANFCSGPCP YLRSADTTHS TVLGLYNTLN PEASASPCCV PQDLEPLTIL YYVGRTPKVE QLSNMVVKSC KCS
Molecular weight
12.9 kDa
Class
Recombinant
Type
Protein
Purity
≥95%
Endotoxin concentration
≤0.1 EU/µg
Activity
ED50 ≤1 ng/mL; determined by the dose-dependent inhibition of HT-2 cell proliferation induced by IL-4.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
purified
Storage buffer
0.01M acetic acid with 20% ethanol
Contains
no preservative
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
Recombinant human TGF-beta3 is a non-glycosylated, disulfide-linked homodimer, containing two 112 amino acid chains.
Target Information
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ16571; H-TGF-b-3; prepro-transforming growth factor beta-3; tgf beta 3; TGF-beta-3; Transforming growth factor; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3
Gene Aliases: ARVD; ARVD1; LDS5; RNHF; TGF-beta3; TGFB3
UniProt ID: (Human) P10600
Entrez Gene ID: (Human) 7043
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