Product References
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.
Cell
Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD
AF-300-01A was used in Enzyme-linked immunosorbent assay to show that only the combination of TNF-α and IFN-γ induced inflammatory cell death characterized by inflammatory cell death, PANoptosis while multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection.
Thu Jan 07 00:00:00 EST 2021
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.
Cell
Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD
AF-300-01A was used in Enzyme-linked immunosorbent assay to show that only the combination of TNF-α and IFN-γ induced inflammatory cell death characterized by inflammatory cell death, PANoptosis while multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection.
Thu Jan 07 00:00:00 EST 2021
Anti-Inflammatory Effects of Lagerstroemia ovalifolia Teijsm. & Binn. in TNFα/IFNγ-Stimulated Keratinocytes.
Evidence-based complementary and alternative medicine : eCAM
Lee HS,Paik JH,Kwon OK,Paryanto I,Yuniato P,Ryu HW,Choi SH,Oh SR,Han SB,Park JW,Ahn KS
Sat Nov 20 00:00:00 EST 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
Wed Aug 11 00:00:00 EDT 2021
Neoantigens elicit T cell responses in breast cancer.
Scientific reports
Morisaki T,Kubo M,Umebayashi M,Yew PY,Yoshimura S,Park JH,Kiyotani K,Kai M,Yamada M,Oda Y,Nakamura Y,Morisaki T,Nakamura M
Wed Jun 30 00:00:00 EDT 2021
TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration.
Cell reports
Russ K,Teku G,Bousset L,Redeker V,Piel S,Savchenko E,Pomeshchik Y,Savistchenko J,Stummann TC,Azevedo C,Collin A,Goldwurm S,Fog K,Elmer E,Vihinen M,Melki R,Roybon L
Tue Mar 23 00:00:00 EDT 2021
Rosuvastatin protects against coronary microembolization-induced cardiac injury via inhibiting NLRP3 inflammasome activation.
Cell death & disease
Chen A,Chen Z,Zhou Y,Wu Y,Xia Y,Lu D,Fan M,Li S,Chen J,Sun A,Zou Y,Qian J,Ge J
Tue Jan 12 00:00:00 EST 2021
Cromolyn inhibits the secretion of inflammatory cytokines by human microglia (HMC3).
Scientific reports
Wang YJ,Monteagudo A,Downey MA,Ashton-Rickardt PG,Elmaleh DR
Tue Apr 13 00:00:00 EDT 2021
The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis.
Oncogene
Zhou Q,Wu X,Wang X,Yu Z,Pan T,Li Z,Chang X,Jin Z,Li J,Zhu Z,Liu B,Su L
Sat Feb 01 00:00:00 EST 2020
Chrysin alleviates imiquimod-induced psoriasis-like skin inflammation and reduces the release of CCL20 and antimicrobial peptides.
Scientific reports
Li HJ,Wu NL,Pu CM,Hsiao CY,Chang DC,Hung CF
Wed Feb 19 00:00:00 EST 2020
Alteration of immunophenotype of human macrophages and monocytes after exposure to cigarette smoke.
Scientific reports
da Silva CO,Gicquel T,Daniel Y,Bártholo T,Vène E,Loyer P,Pôrto LC,Lagente V,Victoni T
Thu Jul 30 00:00:00 EDT 2020
Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes.
bioRxiv : the preprint server for biology
Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD
AF-300-01A was used in In vitro experiments to reveal that blocking the COVID-19 cytokine-mediated inflammatory cell death signaling pathway identified in this study may benefit patients with COVID-19 or other cytokine storm-driven syndromes by limiting inflammation and tissue damage.
Fri Nov 13 00:00:00 EST 2020
Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis.
Cell death discovery
Tsuji G,Hashimoto-Hachiya A,Yen VH,Takemura M,Yumine A,Furue K,Furue M,Nakahara T
Tue Sep 26 00:00:00 EDT 2023
KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma.
Journal of experimental & clinical cancer research : CR
Wang B,Jing T,Jin W,Chen J,Wu C,Wang M,Liu Y
AF-300-01A was used in Cell Culture to identify the role of KIAA1522 in lung adenocarcinomas, and the molecular events that underlie KIAA1522-mediated chemoresistance to the platinum.
Thu Aug 27 00:00:00 EDT 2020
KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma.
Journal of experimental & clinical cancer research : CR
Wang B,Jing T,Jin W,Chen J,Wu C,Wang M,Liu Y
AF-300-01A was used in Cell Culture to identify the role of KIAA1522 in lung adenocarcinomas, and the molecular events that underlie KIAA1522-mediated chemoresistance to the platinum.
Thu Aug 27 00:00:00 EDT 2020
Nasal delivery of Fasudil-modified immune cells exhibits therapeutic potential in experimental autoimmune encephalomyelitis.
CNS neuroscience & therapeutics
Guo SD,Liu CY,Yu JW,Chai Z,Wang Q,Mi XT,Song GB,Li YH,Yang PW,Feng L,Xiao BG,Ma CG
Sat Jun 01 00:00:00 EDT 2019
Methylglyoxal down-regulates the expression of cell cycle associated genes and activates the p53 pathway in human umbilical vein endothelial cells.
Scientific reports
Braun JD,Pastene DO,Breedijk A,Rodriguez A,Hofmann BB,Sticht C,von Ochsenstein E,Allgayer H,van den Born J,Bakker S,Hauske SJ,Krämer BK,Yard BA,Albrecht T
Mon Feb 04 00:00:00 EST 2019
Batroxobin accelerated tissue repair via neutrophil extracellular trap regulation and defibrinogenation in a murine ischemic hindlimb model.
PloS one
Masuda H,Sato A,Shizuno T,Yokoyama K,Suzuki Y,Tokunaga M,Asahara T
AF-300-01A was used in In vitro experiments to investigate whether, and if so, how batroxobin restores ischemic tissue injury in terms of anti-inflammatory effects.
Mon Mar 23 00:00:00 EDT 2020
Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system.
Scientific reports
Hyvärinen T,Hagman S,Ristola M,Sukki L,Veijula K,Kreutzer J,Kallio P,Narkilahti S
Fri Nov 15 00:00:00 EST 2019
The RGD motif is involved in CD97/ADGRE5-promoted cell adhesion and viability of HT1080 cells.
Scientific reports
Tjong WY,Lin HH
Wed Feb 06 00:00:00 EST 2019
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants.
Nature communications
Koenig A,Chen CC,Marçais A,Barba T,Mathias V,Sicard A,Rabeyrin M,Racapé M,Duong-Van-Huyen JP,Bruneval P,Loupy A,Dussurgey S,Ducreux S,Meas-Yedid V,Olivo-Marin JC,Paidassi H,Guillemain R,Taupin JL,Callemeyn J,Morelon E,Nicoletti A,Charreau B,Dubois V,Naesens M,Walzer T,Defrance T,Thaunat O
Mon Nov 25 00:00:00 EST 2019
N-Octanoyl-Dopamine inhibits cytokine production in activated T-cells and diminishes MHC-class-II expression as well as adhesion molecules in IFNγ-stimulated endothelial cells.
Scientific reports
Hofmann BB,Krapp N,Li Y,De La Torre C,Sol M,Braun JD,Kolibabka M,Pallavi P,Krämer BK,Yard BA,Kälsch AI
Wed Dec 18 00:00:00 EST 2019
Pannexin3 inhibits TNF-α-induced inflammatory response by suppressing NF-κB signalling pathway in human dental pulp cells.
Journal of cellular and molecular medicine
Song F,Sun H,Wang Y,Yang H,Huang L,Fu D,Gan J,Huang C
Wed Mar 01 00:00:00 EST 2017
Human cytomegalovirus infection of human adipose-derived stromal/stem cells restricts differentiation along the adipogenic lineage.
Adipocyte
Zwezdaryk KJ,Ferris MB,Strong AL,Morris CA,Bunnell BA,Dhurandhar NV,Gimble JM,Sullivan DE
AF-300-01A was used in Sample Preparation to suggest that human cytomegalovirus (HCMV) infection during adipose-derived stromal/stem cell (ASC) therapy may have a poor outcome due to the virus interfering.
Wed May 04 00:00:00 EDT 2016
Exploiting native forces to capture chromosome conformation in mammalian cell nuclei.
Molecular systems biology
Brant L,Georgomanolis T,Nikolic M,Brackley CA,Kolovos P,van Ijcken W,Grosveld FG,Marenduzzo D,Papantonis A
Fri Dec 09 00:00:00 EST 2016
The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration.
Scientific reports
Wu X,Liu W,Duan Z,Gao Y,Li S,Wang K,Song Y,Shao Z,Yang S,Yang C
Wed Jul 27 00:00:00 EDT 2016
A Tubing-Free Microfluidic Wound Healing Assay Enabling the Quantification of Vascular Smooth Muscle Cell Migration.
Scientific reports
Wei Y,Chen F,Zhang T,Chen D,Jia X,Wang J,Guo W,Chen J
Mon Sep 14 00:00:00 EDT 2015
A Tubing-Free Microfluidic Wound Healing Assay Enabling the Quantification of Vascular Smooth Muscle Cell Migration.
Scientific reports
Wei Y,Chen F,Zhang T,Chen D,Jia X,Wang J,Guo W,Chen J
Mon Sep 14 00:00:00 EDT 2015
Development of 'Redox Arrays' for identifying novel glutathionylated proteins in the secretome.
Scientific reports
Mullen L,Seavill M,Hammouz R,Bottazzi B,Chan P,Vaudry D,Ghezzi P
Tue Sep 29 00:00:00 EDT 2015
Antigenically Modified Human Pluripotent Stem Cells Generate Antigen-Presenting Dendritic Cells.
Scientific reports
Zeng J,Wu C,Wang S
Fri Oct 16 00:00:00 EDT 2015
Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation.
Cell
Yan J,Xiang J,Lin Y,Ma J,Zhang J,Zhang H,Sun J,Danial NN,Liu J,Lin A
Thu Jan 17 00:00:00 EST 2013
Space exploration by the promoter of a long human gene during one transcription cycle.
Nucleic acids research
Larkin JD,Papantonis A,Cook PR,Marenduzzo D
Fri Feb 01 00:00:00 EST 2013
Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence.
PLoS pathogens
Mansur DS,Maluquer de Motes C,Unterholzner L,Sumner RP,Ferguson BJ,Ren H,Strnadova P,Bowie AG,Smith GL
Fri Feb 01 00:00:00 EST 2013
TNF-α has tropic rather than apoptotic activity in human hematopoietic progenitors: involvement of TNF receptor-1 and caspase-8.
Stem cells (Dayton, Ohio)
Mizrahi K,Stein J,Yaniv I,Kaplan O,Askenasy N
Tue Jan 01 00:00:00 EST 2013
Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein.
The Journal of biological chemistry
Basset A,Zhang F,Benes C,Sayeed S,Herd M,Thompson C,Golenbock DT,Camilli A,Malley R
Fri Jan 25 00:00:00 EST 2013
Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model.
Journal of translational medicine
Touboul C,Lis R,Al Farsi H,Raynaud CM,Warfa M,Althawadi H,Mery E,Mirshahi M,Rafii A
Thu Jan 31 00:00:00 EST 2013
Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
The Journal of biological chemistry
Hong S,Kim HY,Kim J,Ha HT,Kim YM,Bae E,Kim TH,Lee KC,Kim SJ
Fri Feb 01 00:00:00 EST 2013
Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling.
Nature methods
Sims JJ,Scavone F,Cooper EM,Kane LA,Youle RJ,Boeke JD,Cohen RE
Sun Feb 05 00:00:00 EST 2012
ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation.
Blood
Weissmüller S,Semmler LY,Kalinke U,Christians S,Müller-Berghaus J,Waibler Z
Thu Jun 28 00:00:00 EDT 2012
Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP.
Blood
Gupta M,Maurer MJ,Wellik LE,Law ME,Han JJ,Ozsan N,Micallef IN,Dogan A,Witzig TE
Thu Nov 22 00:00:00 EST 2012
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
The Journal of experimental medicine
Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H
Mon Oct 22 00:00:00 EDT 2012
TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.
The Journal of experimental medicine
Zhao B,Grimes SN,Li S,Hu X,Ivashkiv LB
Mon Feb 13 00:00:00 EST 2012
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
The Journal of experimental medicine
Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ
Mon Jan 16 00:00:00 EST 2012
IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes.
Proceedings of the National Academy of Sciences of the United States of America
Rossato M,Curtale G,Tamassia N,Castellucci M,Mori L,Gasperini S,Mariotti B,De Luca M,Mirolo M,Cassatella MA,Locati M,Bazzoni F
Tue Nov 06 00:00:00 EST 2012
K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America
Singh K,Deshpande P,Li G,Yu M,Pryshchep S,Cavanagh M,Weyand CM,Goronzy JJ
Tue Jun 19 00:00:00 EDT 2012
Sufficient virus-neutralizing antibody in the central nerve system improves the survival of rabid rats.
Journal of biomedical science
Liao PH,Yang HH,Chou PT,Wang MH,Chu PC,Liu HL,Chen LK
Tue Jun 26 00:00:00 EDT 2012
Platelet-rich plasma inhibits the apoptosis of highly adipogenic homogeneous preadipocytes in an in vitro culture system.
Experimental & molecular medicine
Fukaya Y,Kuroda M,Aoyagi Y,Asada S,Kubota Y,Okamoto Y,Nakayama T,Saito Y,Satoh K,Bujo H
Thu May 31 00:00:00 EDT 2012
NF-κB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the β-catenin pathway.
Oncogene
Thu YM,Su Y,Yang J,Splittgerber R,Na S,Boyd A,Mosse C,Simons C,Richmond A
Thu May 17 00:00:00 EDT 2012
NF-κB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the β-catenin pathway.
Oncogene
Thu YM,Su Y,Yang J,Splittgerber R,Na S,Boyd A,Mosse C,Simons C,Richmond A
Thu May 17 00:00:00 EDT 2012
Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.
Oncogene
Högnäs G,Tuomi S,Veltel S,Mattila E,Murumägi A,Edgren H,Kallioniemi O,Ivaska J
Thu Aug 02 00:00:00 EDT 2012
Paracrine interactions between primary human macrophages and human fibroblasts enhance murine mammary gland humanization in vivo.
Breast cancer research : BCR
Fleming JM,Miller TC,Kidacki M,Ginsburg E,Stuelten CH,Stewart DA,Troester MA,Vonderhaar BK
Mon Jun 25 00:00:00 EDT 2012
Mycobacteria activate γδ T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy.
Cancer immunology, immunotherapy : CII
Fowler DW,Copier J,Wilson N,Dalgleish AG,Bodman-Smith MD
Sun Apr 01 00:00:00 EDT 2012
Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis.
mAbs
Kanakaraj P,Puffer BA,Yao XT,Kankanala S,Boyd E,Shah RR,Wang G,Patel D,Krishnamurthy R,Kaithamana S,Smith RG,LaFleur DW,Barbas CF,Hilbert DM,Kiener PA,Roschke VV
Thu Jan 17 00:00:00 EST 2013
Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis.
mAbs
Kanakaraj P,Puffer BA,Yao XT,Kankanala S,Boyd E,Shah RR,Wang G,Patel D,Krishnamurthy R,Kaithamana S,Smith RG,LaFleur DW,Barbas CF,Hilbert DM,Kiener PA,Roschke VV
Thu Jan 17 00:00:00 EST 2013
Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis.
mAbs
Kanakaraj P,Puffer BA,Yao XT,Kankanala S,Boyd E,Shah RR,Wang G,Patel D,Krishnamurthy R,Kaithamana S,Smith RG,LaFleur DW,Barbas CF,Hilbert DM,Kiener PA,Roschke VV
Thu Jan 17 00:00:00 EST 2013
Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis.
mAbs
Kanakaraj P,Puffer BA,Yao XT,Kankanala S,Boyd E,Shah RR,Wang G,Patel D,Krishnamurthy R,Kaithamana S,Smith RG,LaFleur DW,Barbas CF,Hilbert DM,Kiener PA,Roschke VV
Thu Jan 17 00:00:00 EST 2013
Mesenchymal stem cells transmigrate between and directly through tumor necrosis factor-α-activated endothelial cells via both leukocyte-like and novel mechanisms.
Stem cells (Dayton, Ohio)
Teo GS,Ankrum JA,Martinelli R,Boetto SE,Simms K,Sciuto TE,Dvorak AM,Karp JM,Carman CV
Thu Nov 01 00:00:00 EDT 2012
Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression.
Journal of molecular medicine (Berlin, Germany)
Eaton A,Nagy E,Pacault M,Fauconnier J,Bäck M
Mon Oct 01 00:00:00 EDT 2012
Lipopolysaccharide and sphingosine-1-phosphate cooperate to induce inflammatory molecules and leukocyte adhesion in endothelial cells.
Journal of immunology (Baltimore, Md. : 1950)
Fernández-Pisonero I,Dueñas AI,Barreiro O,Montero O,Sánchez-Madrid F,García-Rodríguez C
Sat Dec 01 00:00:00 EST 2012
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Azcutia V,Stefanidakis M,Tsuboi N,Mayadas T,Croce KJ,Fukuda D,Aikawa M,Newton G,Luscinskas FW
Sat Sep 01 00:00:00 EDT 2012
IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling.
Journal of immunology (Baltimore, Md. : 1950)
Ryzhakov G,Blazek K,Lai CC,Udalova IA
Thu Nov 15 00:00:00 EST 2012
APPL1 regulates basal NF-κB activity by stabilizing NIK.
Journal of cell science
Hupalowska A,Pyrzynska B,Miaczynska M
Sat Sep 01 00:00:00 EDT 2012
Regulation and gene expression profiling of NKG2D positive human cytomegalovirus-primed CD4+ T-cells.
PloS one
Jensen H,Folkersen L,Skov S
Tue Feb 19 00:00:00 EST 2013
Metadherin contributes to the pathogenesis of diffuse large B-cell lymphoma.
PloS one
Ge X,Lv X,Feng L,Liu X,Gao J,Chen N,Wang X
Tue Nov 27 00:00:00 EST 2012
Metadherin contributes to the pathogenesis of diffuse large B-cell lymphoma.
PloS one
Ge X,Lv X,Feng L,Liu X,Gao J,Chen N,Wang X
Tue Nov 27 00:00:00 EST 2012
ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes.
The Journal of biological chemistry
Wilhelmsen K,Mesa KR,Lucero J,Xu F,Hellman J
Fri Aug 03 00:00:00 EDT 2012
The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling.
PloS one
Singh H,Hansen TM,Patel N,Brindle NP
Mon May 14 00:00:00 EDT 2012
Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress.
Molecular systems biology
Tentner AR,Lee MJ,Ostheimer GJ,Samson LD,Lauffenburger DA,Yaffe MB
Tue Jan 31 00:00:00 EST 2012
Altered death receptor signaling promotes epithelial-to-mesenchymal transition and acquired chemoresistance.
Scientific reports
Antoon JW,Lai R,Struckhoff AP,Nitschke AM,Elliott S,Martin EC,Rhodes LV,Yoon NS,Salvo VA,Shan B,Beckman BS,Nephew KP,Burow ME
Sun Mar 17 00:00:00 EDT 2013
The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-κB activation by disturbing the interaction of XIAP with RIP2.
PloS one
Condé C,Rambout X,Lebrun M,Lecat A,Di Valentin E,Dequiedt F,Piette J,Gloire G,Legrand S
Wed Jan 16 00:00:00 EST 2013
DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response.
PloS one
Guo Z,Zhang H,Rao H,Jiang D,Cong X,Feng B,Wang J,Wei L,Chen H
Thu Nov 08 00:00:00 EST 2012
Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade.
PloS one
Zhuo J,Tan EH,Yan B,Tochhawng L,Jayapal M,Koh S,Tay HK,Maciver SK,Hooi SC,Salto-Tellez M,Kumar AP,Goh YC,Lim YC,Yap CT
Tue Jan 29 00:00:00 EST 2013
The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL.
Cell death & disease
Grunert M,Gottschalk K,Kapahnke J,Gündisch S,Kieser A,Jeremias I
Thu Oct 25 00:00:00 EDT 2012
Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer-based virtual screening.
The Journal of biological chemistry
Lieder F,Reisen F,Geppert T,Sollberger G,Beer HD,auf dem Keller U,Schäfer M,Detmar M,Schneider G,Werner S
Fri Sep 21 00:00:00 EDT 2012
The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization.
The Journal of biological chemistry
de Kreuk BJ,Anthony EC,Geerts D,Hordijk PL
Fri Dec 21 00:00:00 EST 2012
Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.
PloS one
Koguchi Y,Buenafe AC,Thauland TJ,Gardell JL,Bivins-Smith ER,Jacoby DB,Slifka MK,Parker DC
Fri Jun 29 00:00:00 EDT 2012
TCR gene transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 epitopes as melanoma-specific immune targets.
Clinical & developmental immunology
Straetemans T,van Brakel M,van Steenbergen S,Broertjes M,Drexhage J,Hegmans J,Lambrecht BN,Lamers C,van Der Bruggen P,Coulie PG,Debets R
Fri Mar 01 00:00:00 EST 2013
MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response.
PloS one
Iyer A,Zurolo E,Prabowo A,Fluiter K,Spliet WG,van Rijen PC,Gorter JA,Aronica E
Tue Mar 05 00:00:00 EST 2013
The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process.
The Journal of biological chemistry
Lecat A,Di Valentin E,Somja J,Jourdan S,Fillet M,Kufer TA,Habraken Y,Sadzot C,Louis E,Delvenne P,Piette J,Legrand-Poels S
Fri Aug 24 00:00:00 EDT 2012
Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling.
The Journal of biological chemistry
Le Goff A,Ji Z,Leclercq B,Bourette RP,Mougel A,Guerardel C,de Launoit Y,Vicogne J,Goormachtigh G,Fafeur V
Fri Oct 12 00:00:00 EDT 2012
IL-36γ/IL-1F9, an innate T-bet target in myeloid cells.
The Journal of biological chemistry
Bachmann M,Scheiermann P,Härdle L,Pfeilschifter J,Mühl H
Fri Dec 07 00:00:00 EST 2012
Differential expression of matrix metalloproteases in human fibroblasts with different origins.
Biochemistry research international
Lindner D,Zietsch C,Becher PM,Schulze K,Schultheiss HP,Tschöpe C,Westermann D
Thu Aug 23 00:00:00 EDT 2012
Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC.
PloS one
Matta H,Gopalakrishnan R,Graham C,Tolani B,Khanna A,Yi H,Suo Y,Chaudhary PM
Wed Sep 19 00:00:00 EDT 2012
Hypoxia-inducible factor-1α regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene.
PloS one
Zhao T,Gao S,Wang X,Liu J,Duan Y,Yuan Z,Sheng J,Li S,Wang F,Yu M,Ren H,Hao J
Tue Feb 19 00:00:00 EST 2013
Decreased expression of vitamin D receptors in neointimal lesions following coronary artery angioplasty in atherosclerotic swine.
PloS one
Gupta GK,Agrawal T,Del Core MG,Hunter WJ,Agrawal DK
Thu Jan 10 00:00:00 EST 2013
The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma.
PloS one
Kanitz A,Imig J,Dziunycz PJ,Primorac A,Galgano A,Hofbauer GF,Gerber AP,Detmar M
Thu Jun 20 00:00:00 EDT 2013
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.
Nature
Rayner KJ,Esau CC,Hussain FN,McDaniel AL,Marshall SM,van Gils JM,Ray TD,Sheedy FJ,Goedeke L,Liu X,Khatsenko OG,Kaimal V,Lees CJ,Fernandez-Hernando C,Fisher EA,Temel RE,Moore KJ
Wed Oct 19 00:00:00 EDT 2011
Activation of STAT6 by STING is critical for antiviral innate immunity.
Cell
Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z
Fri Oct 14 00:00:00 EDT 2011
Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.
Immunity
Mayer-Barber KD,Andrade BB,Barber DL,Hieny S,Feng CG,Caspar P,Oland S,Gordon S,Sher A
Fri Dec 23 00:00:00 EST 2011
Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.
Blood
Bouma G,Mendoza-Naranjo A,Blundell MP,de Falco E,Parsley KL,Burns SO,Thrasher AJ
Thu Sep 01 00:00:00 EDT 2011
The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma.
Journal of the National Cancer Institute
Ai J,Tang Q,Wu Y,Xu Y,Feng T,Zhou R,Chen Y,Gao X,Zhu Q,Yue X,Pan Q,Xu S,Li J,Huang M,Daugherty-Holtrop J,He Y,Xu HE,Fan J,Ding J,Geng M
Wed Nov 16 00:00:00 EST 2011
Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum.
Bioorganic & medicinal chemistry
Grienke U,Mihály-Bison J,Schuster D,Afonyushkin T,Binder M,Guan SH,Cheng CR,Wolber G,Stuppner H,Guo DA,Bochkov VN,Rollinger JM
Tue Nov 15 00:00:00 EST 2011
Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC.
PloS one
de Jong E,Winkel P,Poelstra K,Prakash J
Fri Feb 03 00:00:00 EST 2012
Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa.
PloS one
Harel E,Rubinstein A,Nissan A,Khazanov E,Nadler Milbauer M,Barenholz Y,Tirosh B
Tue Feb 14 00:00:00 EST 2012
ST2 and IL-33 in pregnancy and pre-eclampsia.
PloS one
Granne I,Southcombe JH,Snider JV,Tannetta DS,Child T,Redman CW,Sargent IL
Fri Feb 03 00:00:00 EST 2012
Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts.
Journal of inflammation (London, England)
Asp L,Johansson AS,Mann A,Owe-Larsson B,Urbanska EM,Kocki T,Kegel M,Engberg G,Lundkvist GB,Karlsson H
Sat Oct 08 00:00:00 EDT 2011
Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors.
Molecular & cellular proteomics : MCP
Reis CR,van Assen AH,Quax WJ,Cool RH
Sat Jan 01 00:00:00 EST 2011
TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.
The Journal of biological chemistry
Wang J,Markova D,Anderson DG,Zheng Z,Shapiro IM,Risbud MV
Fri Nov 18 00:00:00 EST 2011
TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.
The Journal of biological chemistry
Wang J,Markova D,Anderson DG,Zheng Z,Shapiro IM,Risbud MV
Fri Nov 18 00:00:00 EST 2011
Entamoeba lysyl-tRNA synthetase contains a cytokine-like domain with chemokine activity towards human endothelial cells.
PLoS neglected tropical diseases
Castro de Moura M,Miro F,Han JM,Kim S,Celada A,Ribas de Pouplana L
Tue Nov 01 00:00:00 EDT 2011
Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells.
PloS one
Aldhous MC,Soo K,Stark LA,Ulanicka AA,Easterbrook JE,Dunlop MG,Satsangi J
Tue Feb 28 00:00:00 EST 2012
The therapeutic effect of cytokine-induced killer cells on pancreatic cancer enhanced by dendritic cells pulsed with K-ras mutant peptide.
Clinical & developmental immunology
Tan G,Zhang X,Feng H,Luo H,Wang Z
Wed Jun 06 00:00:00 EDT 2012
Comparing the immunosuppressive potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells.
Journal of neuroinflammation
Dao MA,Tate CC,Aizman I,McGrogan M,Case CC
Fri Oct 07 00:00:00 EDT 2011
Different signaling pathways stimulate a disintegrin and metalloprotease-17 (ADAM17) in neutrophils during apoptosis and activation.
The Journal of biological chemistry
Wang Y,Robertson JD,Walcheck B
Fri Nov 11 00:00:00 EST 2011
Flt3 ligand promotes the generation of a distinct CD34(+) human natural killer cell progenitor that responds to interleukin-15.
Blood
Yu H,Fehniger TA,Fuchshuber P,Thiel KS,Vivier E,Carson WE,Caligiuri MA
Sun Nov 15 00:00:00 EST 1998
