Product References
Effect of minor amounts of β-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of β-tricalcium phosphate cylinders.
Bioactive materials
Le Gars Santoni B,Niggli L,Dolder S,Loeffel O,Sblendorio GA,Heuberger R,Maazouz Y,Stähli C,Döbelin N,Bowen P,Hofstetter W,Bohner M
310-01 was used in Cell Culture to investigate the effects of β-calcium pyrophosphate and hydroxyapatite impurities on β-Tricalcium Phosphate bone grafts.
Fri Apr 01 00:00:00 EDT 2022
A multi-organ chip with matured tissue niches linked by vascular flow.
Nature biomedical engineering
Ronaldson-Bouchard K,Teles D,Yeager K,Tavakol DN,Zhao Y,Chramiec A,Tagore S,Summers M,Stylianos S,Tamargo M,Lee BM,Halligan SP,Abaci EH,Guo Z,Jacków J,Pappalardo A,Shih J,Soni RK,Sonar S,German C,Christiano AM,Califano A,Hirschi KK,Chen CS,Przekwas A,Vunjak-Novakovic G
310-01 was used in Cell Culture to report the development and applicability of a tissue-chip system in which matured human heart, liver, bone and skin tissue niches are linked by recirculating vascular flow to allow for the recapitulation of interdependent organ functions.
Fri Apr 01 00:00:00 EDT 2022
Protocol of Co-Culture of Human Osteoblasts and Osteoclasts to Test Biomaterials for Bone Tissue Engineering.
Methods and protocols
Borciani G,Montalbano G,Baldini N,Vitale-Brovarone C,Ciapetti G
Fri Jan 14 00:00:00 EST 2022
DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis.
The Journal of experimental medicine
Kaifu T,Yabe R,Maruhashi T,Chung SH,Tateno H,Fujikado N,Hirabayashi J,Iwakura Y
Mon Dec 06 00:00:00 EST 2021
MEF2C regulates osteoclastogenesis and pathologic bone resorption via c-FOS.
Bone research
Fujii T,Murata K,Mun SH,Bae S,Lee YJ,Pannellini T,Kang K,Oliver D,Park-Min KH,Ivashkiv LB
Mon Jan 11 00:00:00 EST 2021
Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers.
Gut microbes
Fasciano AC,Dasanayake GS,Estes MK,Zachos NC,Breault DT,Isberg RR,Tan S,Mecsas J
310-01 was used in Cell Culture to indicate that early infectious stage Yersinia pseudotuberculosis (Yptb) more effectively penetrates M cells while the host may defend against M cell penetration of host-adapted Yptb.
Tue Mar 01 00:00:00 EST 2022
Mutations in Profilin 1 Cause Early-Onset Paget's Disease of Bone With Giant Cell Tumors.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wei Z,Li S,Tao X,Zhu G,Sun Z,Wei Z,Jiao Q,Zhang H,Chen L,Li B,Zhang Z,Yue H
Tue Jun 01 00:00:00 EDT 2021
Mutations in Profilin 1 Cause Early-Onset Paget's Disease of Bone With Giant Cell Tumors.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wei Z,Li S,Tao X,Zhu G,Sun Z,Wei Z,Jiao Q,Zhang H,Chen L,Li B,Zhang Z,Yue H
Tue Jun 01 00:00:00 EDT 2021
In vitro and in vivo detection of tunneling nanotubes in normal and pathological osteoclastogenesis involving osteoclast fusion.
Laboratory investigation; a journal of technical methods and pathology
Zhang JQ,Takahashi A,Gu JY,Zhang X,Kyumoto-Nakamura Y,Kukita A,Uehara N,Hiura H,Yamaza T,Kukita T
Wed Dec 01 00:00:00 EST 2021
Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures.
Scientific reports
Kennedy JW,Tsimbouri PM,Campsie P,Sood S,Childs PG,Reid S,Young PS,Meek DRM,Goodyear CS,Dalby MJ
Tue Nov 23 00:00:00 EST 2021
Human Serum Enhances Biomimicry of Engineered Tissue Models of Bone and Cancer.
Frontiers in bioengineering and biotechnology
Villasante A,Robinson ST,Cohen AR,Lock R,Guo XE,Vunjak-Novakovic G
310-01 was used in Cell Culture to support the utility of human serum for bioengineering of bone and bone cancers.
Tue Feb 14 00:00:00 EST 2023
Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs.
Scientific reports
Larrouture QC,Cribbs AP,Rao SR,Philpott M,Snelling SJ,Knowles HJ
Mon Nov 22 00:00:00 EST 2021
Regulatory B Cells (Bregs) Inhibit Osteoclastogenesis and Play a Potential Role in Ameliorating Ovariectomy-Induced Bone Loss.
Frontiers in immunology
Sapra L,Bhardwaj A,Mishra PK,Garg B,Verma B,Mishra GC,Srivastava RK
310-01 was used in Cell Culture to suggest that modulations in the percentage of Bregs population along with its reduced potential to produce IL-10 might further exacerbate the observed bone loss in ovx mice.
Thu Nov 04 00:00:00 EDT 2021
Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice.
Scientific reports
Sapra L,Dar HY,Bhardwaj A,Pandey A,Kumari S,Azam Z,Upmanyu V,Anwar A,Shukla P,Mishra PK,Saini C,Verma B,Srivastava RK
Tue Jan 19 00:00:00 EST 2021
RANK promotes colorectal cancer migration and invasion by activating the Ca2+-calcineurin/NFATC1-ACP5 axis.
Cell death & disease
Liang Q,Wang Y,Lu Y,Zhu Q,Xie W,Tang N,Huang L,An T,Zhang D,Yan A,Liu S,Ye L,Zhu C
Thu Apr 01 00:00:00 EDT 2021
B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction.
Cell death & disease
Oh Y,Park R,Kim SY,Park SH,Jo S,Kim TH,Ji JD
Wed Oct 20 00:00:00 EDT 2021
Inhibition of the CXCL9-CXCR3 axis suppresses the progression of experimental apical periodontitis by blocking macrophage migration and activation.
Scientific reports
Hasegawa T,Venkata Suresh V,Yahata Y,Nakano M,Suzuki S,Suzuki S,Yamada S,Kitaura H,Mizoguchi I,Noiri Y,Handa K,Saito M
Thu Jan 28 00:00:00 EST 2021
Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin.
The Journal of clinical investigation
Andreev D,Liu M,Weidner D,Kachler K,Faas M,Grüneboom A,Schlötzer-Schrehardt U,Muñoz LE,Steffen U,Grötsch B,Killy B,Krönke G,Luebke AM,Niemeier A,Wehrhan F,Lang R,Schett G,Bozec A
Tue Sep 01 00:00:00 EDT 2020
Adult Osteosclerotic Metaphyseal Dysplasia With Progressive Osteonecrosis of the Jaws and Abnormal Bone Resorption Pattern Due to a LRRK1 Splice Site Mutation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Howaldt A,Hennig AF,Rolvien T,Rössler U,Stelzer N,Knaus A,Böttger S,Zustin J,Geißler S,Oheim R,Amling M,Howaldt HP,Kornak U
Wed Jul 01 00:00:00 EDT 2020
LncRNA-mRNA expression profiles and functional networks in osteoclast differentiation.
Journal of cellular and molecular medicine
Liu W,Li Z,Cai Z,Xie Z,Li J,Li M,Cen S,Tang S,Zheng G,Ye G,Su H,Wang S,Wang P,Shen H,Wu Y
Tue Sep 01 00:00:00 EDT 2020
LncRNA-mRNA expression profiles and functional networks in osteoclast differentiation.
Journal of cellular and molecular medicine
Liu W,Li Z,Cai Z,Xie Z,Li J,Li M,Cen S,Tang S,Zheng G,Ye G,Su H,Wang S,Wang P,Shen H,Wu Y
Tue Sep 01 00:00:00 EDT 2020
Osteoidosis leads to altered differentiation and function of osteoclasts.
Journal of cellular and molecular medicine
Grünherz L,Prein C,Winkler T,Kirsch M,Hopfner U,Streichert T,Clausen-Schaumann H,Zustin J,Kirchhof K,Morlock MM,Machens HG,Schilling AF
Fri May 01 00:00:00 EDT 2020
Osteoblast-Osteoclast Coculture Amplifies Inhibitory Effects of FG-4592 on Human Osteoclastogenesis and Reduces Bone Resorption.
JBMR plus
Hulley PA,Papadimitriou-Olivgeri I,Knowles HJ
Wed Jul 01 00:00:00 EDT 2020
Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts.
Bio-protocol
Chen IP
310-01 was used in Cell Culture to study efficient differentiation of hiPSCs into osteoclasts using a three-stage protocol which does not require a co-culture system; induces EBs into mesoderm differentiation in a homogenous manner; uses less cytokines for differentiation; requires only a short time for osteoclast maturation and produces sufficient numbers of osteoclasts for subsequent molecular analyses.
Sun Dec 20 00:00:00 EST 2020
Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation.
Scientific reports
Kang IS,Jang JS,Kim C
Mon Apr 27 00:00:00 EDT 2020
Establishment and validation of an in vitro co-culture model for oral cell lines using human PBMC-derived osteoclasts, osteoblasts, fibroblasts and keratinocytes.
Scientific reports
Steller D,Scheibert A,Sturmheit T,Hakim SG
Thu Oct 08 00:00:00 EDT 2020
Aminothiazoles inhibit osteoclastogenesis and PGE2 production in LPS-stimulated co-cultures of periodontal ligament and RAW 264.7 cells, and RANKL-mediated osteoclastogenesis and bone resorption in PBMCs.
Journal of cellular and molecular medicine
Kats A,Gerasimcik N,Näreoja T,Nederberg J,Grenlöv S,Lagnöhed E,Desai S,Andersson G,Yucel-Lindberg T
Fri Feb 01 00:00:00 EST 2019
The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis.
Scientific reports
Ashraf S,Radhi M,Gowler P,Burston JJ,Gandhi RD,Thorn GJ,Piccinini AM,Walsh DA,Chapman V,de Moor CH
Mon Mar 18 00:00:00 EDT 2019
Abnormal inhibition of osteoclastogenesis by mesenchymal stem cells through the miR-4284/CXCL5 axis in ankylosing spondylitis.
Cell death & disease
Liu W,Wang P,Xie Z,Wang S,Ma M,Li J,Li M,Cen S,Tang S,Zheng G,Ye G,Wu X,Wu Y,Shen H
Mon Feb 25 00:00:00 EST 2019
TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion.
Communications biology
Yamamoto M,Abe C,Wakinaga S,Sakane K,Yumiketa Y,Taguchi Y,Matsumura T,Ishikawa K,Fujimoto J,Semba K,Miyauchi M,Akiyama T,Inoue JI
310-01 was used in In vitro experiments to show that TRAF6 is crucial for both mammary stem cell maintenance and pregnancy-induced epithelial cell expansion.
Mon Apr 20 00:00:00 EDT 2020
Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation.
Bone research
Carey HA,Hildreth BE,Geisler JA,Nickel MC,Cabrera J,Ghosh S,Jiang Y,Yan J,Lee J,Makam S,Young NA,Valiente GR,Jarjour WN,Huang K,Rosol TJ,Toribio RE,Charles JF,Ostrowski MC,Sharma SM
Tue Sep 29 00:00:00 EDT 2020
Bone protection by inhibition of microRNA-182.
Nature communications
Inoue K,Deng Z,Chen Y,Giannopoulou E,Xu R,Gong S,Greenblatt MB,Mangala LS,Lopez-Berestein G,Kirsch DG,Sood AK,Zhao L,Zhao B
Fri Oct 05 00:00:00 EDT 2018
SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.
Nature communications
Fukuda M,Yoshizawa T,Karim MF,Sobuz SU,Korogi W,Kobayasi D,Okanishi H,Tasaki M,Ono K,Sawa T,Sato Y,Chirifu M,Masuda T,Nakamura T,Tanoue H,Nakashima K,Kobashigawa Y,Morioka H,Bober E,Ohtsuki S,Yamagata Y,Ando Y,Oike Y,Araki N,Takeda S,Mizuta H,Yamagata K
Thu Jul 19 00:00:00 EDT 2018
oxLDL inhibits differentiation and functional activity of osteoclasts via scavenger receptor-A mediated autophagy and cathepsin K secretion.
Scientific reports
Dawodu D,Patecki M,Hegermann J,Dumler I,Haller H,Kiyan Y
Thu Aug 02 00:00:00 EDT 2018
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.
Nature communications
Mizoguchi F,Slowikowski K,Wei K,Marshall JL,Rao DA,Chang SK,Nguyen HN,Noss EH,Turner JD,Earp BE,Blazar PE,Wright J,Simmons BP,Donlin LT,Kalliolias GD,Goodman SM,Bykerk VP,Ivashkiv LB,Lederer JA,Hacohen N,Nigrovic PA,Filer A,Buckley CD,Raychaudhuri S,Brenner MB
Fri Feb 23 00:00:00 EST 2018
Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis.
Immunity
Murata K,Fang C,Terao C,Giannopoulou EG,Lee YJ,Lee MJ,Mun SH,Bae S,Qiao Y,Yuan R,Furu M,Ito H,Ohmura K,Matsuda S,Mimori T,Matsuda F,Park-Min KH,Ivashkiv LB
Tue Jul 18 00:00:00 EDT 2017
MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα.
The Journal of clinical investigation
Bae S,Lee MJ,Mun SH,Giannopoulou EG,Yong-Gonzalez V,Cross JR,Murata K,Giguère V,van der Meulen M,Park-Min KH
Fri Jun 30 00:00:00 EDT 2017
Interferon-γ Released by Activated CD8+ T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves.
The American journal of pathology
Nagy E,Lei Y,Martínez-Martínez E,Body SC,Schlotter F,Creager M,Assmann A,Khabbaz K,Libby P,Hansson GK,Aikawa E
310-01 was used in Cell Culture to investigate whether CD8 T cells modulate calcification in calcific aortic valve disease.
Thu Jun 01 00:00:00 EDT 2017
Tissue-Engineered Model of Human Osteolytic Bone Tumor.
Tissue engineering. Part C, Methods
Villasante A,Marturano-Kruik A,Robinson ST,Liu Z,Guo XE,Vunjak-Novakovic G
310-01 was used in Cell Culture to study a novel bioengineered model of Ewing's sarcoma (ES) that incorporates the osteolytic process which can be used to investigate how tumor cells invade bone.
Wed Feb 01 00:00:00 EST 2017
Effects of O-methylated (-)-epigallocatechin gallate (EGCG) on LPS-induced osteoclastogenesis, bone resorption, and alveolar bone loss in mice.
FEBS open bio
Tominari T,Ichimaru R,Yoshinouchi S,Matsumoto C,Watanabe K,Hirata M,Grundler FMW,Inada M,Miyaura C
Fri Dec 01 00:00:00 EST 2017
Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis.
Scientific reports
Lee CH,Bae SJ,Kim M
Tue Sep 19 00:00:00 EDT 2017
Vitamin D receptor expression in human bone tissue and dose-dependent activation in resorbing osteoclasts.
Bone research
Zarei A,Morovat A,Javaid K,Brown CP
Tue Nov 07 00:00:00 EST 2023
RBP-J-Regulated miR-182 Promotes TNF-α-Induced Osteoclastogenesis.
Journal of immunology (Baltimore, Md. : 1950)
Miller CH,Smith SM,Elguindy M,Zhang T,Xiang JZ,Hu X,Ivashkiv LB,Zhao B
Wed Jun 15 00:00:00 EDT 2016
Soluble RANKL Cleaved from Activated Lymphocytes by TNF-α-Converting Enzyme Contributes to Osteoclastogenesis in Periodontitis.
Journal of immunology (Baltimore, Md. : 1950)
Kanzaki H,Makihira S,Suzuki M,Ishii T,Movila A,Hirschfeld J,Mawardi H,Lin X,Han X,Taubman MA,Kawai T
Tue Nov 15 00:00:00 EST 2016
Cutting Edge: EZH2 Promotes Osteoclastogenesis by Epigenetic Silencing of the Negative Regulator IRF8.
Journal of immunology (Baltimore, Md. : 1950)
Fang C,Qiao Y,Mun SH,Lee MJ,Murata K,Bae S,Zhao B,Park-Min KH,Ivashkiv LB
Wed Jun 01 00:00:00 EDT 2016
MiR-142-3p is a RANKL-dependent inducer of cell death in osteoclasts.
Scientific reports
Fordham JB,Guilfoyle K,Naqvi AR,Nares S
Tue Apr 26 00:00:00 EDT 2016
In vitro model of bone to facilitate measurement of adhesion forces and super-resolution imaging of osteoclasts.
Scientific reports
Deguchi T,Alanne MH,Fazeli E,Fagerlund KM,Pennanen P,Lehenkari P,Hänninen PE,Peltonen J,Näreoja T
Thu Mar 03 00:00:00 EST 2016
Silicon Nitride: A Synthetic Mineral for Vertebrate Biology.
Scientific reports
Pezzotti G,McEntire BJ,Bock R,Boffelli M,Zhu W,Vitale E,Puppulin L,Adachi T,Yamamoto T,Kanamura N,Bal BS
Fri Aug 19 00:00:00 EDT 2016
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation.
Nature communications
Li D,Liu J,Guo B,Liang C,Dang L,Lu C,He X,Cheung HY,Xu L,Lu C,He B,Liu B,Shaikh AB,Li F,Wang L,Yang Z,Au DW,Peng S,Zhang Z,Zhang BT,Pan X,Qian A,Shang P,Xiao L,Jiang B,Wong CK,Xu J,Bian Z,Liang Z,Guo DA,Zhu H,Tan W,Lu A,Zhang G
Mon Mar 07 00:00:00 EST 2016
Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes.
The Journal of biological chemistry
Smith GA,Howell GJ,Phillips C,Muench SP,Ponnambalam S,Harrison MA
Fri Apr 15 00:00:00 EDT 2016
Structural simulation of adenosine phosphate via plumbagin and zoledronic acid competitively targets JNK/Erk to synergistically attenuate osteoclastogenesis in a breast cancer model.
Cell death & disease
Qiao H,Wang TY,Yu ZF,Han XG,Liu XQ,Wang YG,Fan QM,Qin A,Tang TT
Thu Feb 11 00:00:00 EST 2016
Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1.
Experimental & molecular medicine
Song MK,Lee ZH,Kim HH
Fri Dec 18 00:00:00 EST 2015
Effective Small Interfering RNA Therapy to Treat CLCN7-dependent Autosomal Dominant Osteopetrosis Type 2.
Molecular therapy. Nucleic acids
Capulli M,Maurizi A,Ventura L,Rucci N,Teti A
310-01 was used in Cell Culture to investigate miRNA effects on autosomal dominant osteopetrosis type 2.
Tue Sep 01 00:00:00 EDT 2015
Effective Small Interfering RNA Therapy to Treat CLCN7-dependent Autosomal Dominant Osteopetrosis Type 2.
Molecular therapy. Nucleic acids
Capulli M,Maurizi A,Ventura L,Rucci N,Teti A
310-01 was used in Cell Culture to investigate miRNA effects on autosomal dominant osteopetrosis type 2.
Tue Sep 01 00:00:00 EDT 2015
Lipocalin 2: a new mechanoresponding gene regulating bone homeostasis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Rucci N,Capulli M,Piperni SG,Cappariello A,Lau P,Frings-Meuthen P,Heer M,Teti A
310-01 was used in Cell Culture to investigate mechanoresponding properties of LCN2 in mouse osteoblasts.
Sun Feb 01 00:00:00 EST 2015
Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss.
Nature communications
Harre U,Lang SC,Pfeifle R,Rombouts Y,Frühbeißer S,Amara K,Bang H,Lux A,Koeleman CA,Baum W,Dietel K,Gröhn F,Malmström V,Klareskog L,Krönke G,Kocijan R,Nimmerjahn F,Toes RE,Herrmann M,Scherer HU,Schett G
Tue Mar 31 00:00:00 EDT 2015
Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor κB (RANK)-dependent formation of multinucleated osteoclasts.
The Journal of biological chemistry
Oh J,Kim JY,Kim HS,Oh JC,Cheon YH,Park J,Yoon KH,Lee MS,Youn BS
Fri Jan 23 00:00:00 EST 2015
Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor κB (RANK)-dependent formation of multinucleated osteoclasts.
The Journal of biological chemistry
Oh J,Kim JY,Kim HS,Oh JC,Cheon YH,Park J,Yoon KH,Lee MS,Youn BS
Fri Jan 23 00:00:00 EST 2015
Caveolin-1 regulates osteoclastogenesis and bone metabolism in a sex-dependent manner.
The Journal of biological chemistry
Lee YD,Yoon SH,Park CK,Lee J,Lee ZH,Kim HH
Fri Mar 06 00:00:00 EST 2015
JAK2-STAT3 blockade by AG490 suppresses autoimmune arthritis in mice via reciprocal regulation of regulatory T Cells and Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Park JS,Lee J,Lim MA,Kim EK,Kim SM,Ryu JG,Lee JH,Kwok SK,Park KS,Kim HY,Park SH,Cho ML
Thu May 01 00:00:00 EDT 2014
Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T.
The Journal of biological chemistry
Takahashi S,Nagano S,Nogawa T,Kanoh N,Uramoto M,Kawatani M,Shimizu T,Miyazawa T,Shiro Y,Osada H
Fri Nov 21 00:00:00 EST 2014
The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF).
The Journal of biological chemistry
Bronisz A,Carey HA,Godlewski J,Sif S,Ostrowski MC,Sharma SM
Fri Jan 03 00:00:00 EST 2014
Dynein light chain LC8 inhibits osteoclast differentiation and prevents bone loss in mice.
Journal of immunology (Baltimore, Md. : 1950)
Kim H,Hyeon S,Kim H,Yang Y,Huh JY,Park DR,Lee H,Seo DH,Kim HS,Lee SY,Jeong W
Fri Feb 01 00:00:00 EST 2013
Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques.
Journal of immunology (Baltimore, Md. : 1950)
Kotani M,Kikuta J,Klauschen F,Chino T,Kobayashi Y,Yasuda H,Tamai K,Miyawaki A,Kanagawa O,Tomura M,Ishii M
Tue Jan 15 00:00:00 EST 2013
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R
Tue Jan 01 00:00:00 EST 2013
The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation.
The Journal of biological chemistry
Kogawa M,Hisatake K,Atkins GJ,Findlay DM,Enoki Y,Sato T,Gray PC,Kanesaki-Yatsuka Y,Anderson PH,Wada S,Kato N,Fukuda A,Katayama S,Tsujimoto M,Yoda T,Suda T,Okazaki Y,Matsumoto M
Fri Oct 25 00:00:00 EDT 2013
Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.
Blood
Tai YT,Chang BY,Kong SY,Fulciniti M,Yang G,Calle Y,Hu Y,Lin J,Zhao JJ,Cagnetta A,Cea M,Sellitto MA,Zhong MY,Wang Q,Acharya C,Carrasco DR,Buggy JJ,Elias L,Treon SP,Matsui W,Richardson P,Munshi NC,Anderson KC
Thu Aug 30 00:00:00 EDT 2012
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin.
The Journal of clinical investigation
Harre U,Georgess D,Bang H,Bozec A,Axmann R,Ossipova E,Jakobsson PJ,Baum W,Nimmerjahn F,Szarka E,Sarmay G,Krumbholz G,Neumann E,Toes R,Scherer HU,Catrina AI,Klareskog L,Jurdic P,Schett G
Tue May 01 00:00:00 EDT 2012
TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.
The Journal of experimental medicine
Zhao B,Grimes SN,Li S,Hu X,Ivashkiv LB
Mon Feb 13 00:00:00 EST 2012
Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice.
Proceedings of the National Academy of Sciences of the United States of America
Nakamichi Y,Mizoguchi T,Arai A,Kobayashi Y,Sato M,Penninger JM,Yasuda H,Kato S,DeLuca HF,Suda T,Udagawa N,Takahashi N
Tue Jun 19 00:00:00 EDT 2012
RANK-dependent autosomal recessive osteopetrosis: characterization of five new cases with novel mutations.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Pangrazio A,Cassani B,Guerrini MM,Crockett JC,Marrella V,Zammataro L,Strina D,Schulz A,Schlack C,Kornak U,Mellis DJ,Duthie A,Helfrich MH,Durandy A,Moshous D,Vellodi A,Chiesa R,Veys P,Lo Iacono N,Vezzoni P,Fischer A,Villa A,Sobacchi C
Wed Feb 01 00:00:00 EST 2012
Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis.
Arthritis research & therapy
Hwang SJ,Choi B,Kang SS,Chang JH,Kim YG,Chung YH,Sohn DH,So MW,Lee CK,Robinson WH,Chang EJ
Fri Jan 20 00:00:00 EST 2012
Inhibition of osteoclast generation: a novel function of the bone morphogenetic protein 7/osteogenic protein 1.
Mediators of inflammation
Maurer T,Zimmermann G,Maurer S,Stegmaier S,Wagner C,Hänsch GM
Mon Feb 04 00:00:00 EST 2013
Inhibition of osteoclastogenesis by RNA interference targeting RANK.
BMC musculoskeletal disorders
Ma R,Xu J,Dong B,Kauther MD,Jäger M,Wedemeyer C
Wed Aug 22 00:00:00 EDT 2012
TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis.
The Journal of biological chemistry
Yoon SH,Lee YD,Ha J,Lee Y,Kim HH
Fri Aug 24 00:00:00 EDT 2012
Adipokines in psoriatic arthritis patients: the correlations with osteoclast precursors and bone erosions.
PloS one
Xue Y,Jiang L,Cheng Q,Chen H,Yu Y,Lin Y,Yang X,Kong N,Zhu X,Xu X,Wan W,Zou H
Tue Aug 26 00:00:00 EDT 2014
Prevention of bone growth defects, increased bone resorption and marrow adiposity with folinic acid in rats receiving long-term methotrexate.
PloS one
Fan CM,Foster BK,Hui SK,Xian CJ
Thu Apr 11 00:00:00 EDT 2013
Divergent resorbability and effects on osteoclast formation of commonly used bone substitutes in a human in vitro-assay.
PloS one
Keller J,Brink S,Busse B,Schilling AF,Schinke T,Amling M,Lange T
Tue Apr 02 00:00:00 EDT 2013
Regulation of MMP-9 by a WIN-binding site in the monocyte-macrophage system independent from cannabinoid receptors.
PloS one
Tauber S,Paulsen K,Wolf S,Synwoldt P,Pahl A,Schneider-Stock R,Ullrich O
Tue Apr 23 00:00:00 EDT 2013
Rho GTPase expression in human myeloid cells.
PloS one
van Helden SF,Anthony EC,Dee R,Hordijk PL
Wed May 15 00:00:00 EDT 2013
Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects.
PloS one
Garcia-Gomez A,Ocio EM,Crusoe E,Santamaria C,Hernández-Campo P,Blanco JF,Sanchez-Guijo FM,Hernández-Iglesias T,Briñón JG,Fisac-Herrero RM,Lee FY,Pandiella A,San Miguel JF,Garayoa M
Mon Sep 10 00:00:00 EDT 2012
Osteoclast-gene expression profiling reveals osteoclast-derived CCR2 chemokines promoting myeloma cell migration.
Blood
Moreaux J,Hose D,Kassambara A,Reme T,Moine P,Requirand G,Goldschmidt H,Klein B
Thu Jan 27 00:00:00 EST 2011
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.
Nature protocols
Choi KD,Vodyanik M,Slukvin II
Tue Mar 01 00:00:00 EST 2011
MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases.
Breast cancer research : BCR
Pivetta E,Scapolan M,Pecolo M,Wassermann B,Abu-Rumeileh I,Balestreri L,Borsatti E,Tripodo C,Colombatti A,Spessotto P
Thu Oct 27 00:00:00 EDT 2011
Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine.
Arthritis research & therapy
Ivanovska N,Dimitrova P
Wed Mar 16 00:00:00 EDT 2011
Flemingia macrophylla Extract Ameliorates Experimental Osteoporosis in Ovariectomized Rats.
Evidence-based complementary and alternative medicine : eCAM
Ho HY,Wu JB,Lin WC
Thu Aug 23 00:00:00 EDT 2012
Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis.
The Journal of biological chemistry
Mabilleau G,Chappard D,Sabokbar A
Fri Feb 04 00:00:00 EST 2011
Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis.
Proceedings of the National Academy of Sciences of the United States of America
Söderström K,Stein E,Colmenero P,Purath U,Müller-Ladner U,de Matos CT,Tarner IH,Robinson WH,Engleman EG
Tue Jul 20 00:00:00 EDT 2010
Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Nishikawa K,Nakashima T,Hayashi M,Fukunaga T,Kato S,Kodama T,Takahashi S,Calame K,Takayanagi H
Tue Feb 16 00:00:00 EST 2010
Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Knowles HJ,Cleton-Jansen AM,Korsching E,Athanasou NA
Wed Dec 01 00:00:00 EST 2010
Circulating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion.
Arthritis research & therapy
Dalbeth N,Pool B,Smith T,Callon KE,Lobo M,Taylor WJ,Jones PB,Cornish J,McQueen FM
Wed Jan 19 00:00:00 EST 2011
Direct inhibition of human RANK+ osteoclast precursors identifies a homeostatic function of IL-1beta.
Journal of immunology (Baltimore, Md. : 1950)
Lee B,Kim TH,Jun JB,Yoo DH,Woo JH,Choi SJ,Lee YH,Song GG,Sohn J,Park-Min KH,Ivashkiv LB,Ji JD
Mon Nov 15 00:00:00 EST 2010
The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate.
Journal of immunology (Baltimore, Md. : 1950)
James DE,Nestor BJ,Sculco TP,Ivashkiv LB,Ross FP,Goldring SR,Purdue PE
Thu Jul 15 00:00:00 EDT 2010
Osteoblasts are a major source of inflammatory cytokines in the tumor microenvironment of bone metastatic breast cancer.
Journal of cellular biochemistry
Bussard KM,Venzon DJ,Mastro AM
Wed Dec 01 00:00:00 EST 2010
Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum.
PloS one
Curnow SJ,Fairclough M,Schmutz C,Kissane S,Denniston AK,Nash K,Buckley CD,Lord JM,Salmon M
Thu Mar 18 00:00:00 EDT 2010
Amorphigenin inhibits Osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells.
Anatomy & cell biology
Kim BG,Kwak HB,Choi EY,Kim HS,Kim MH,Kim SH,Choi MK,Chun CH,Oh J,Kim JJ
Wed Dec 01 00:00:00 EST 2010
The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth.
Blood
Pennisi A,Ling W,Li X,Khan S,Shaughnessy JD,Barlogie B,Yaccoby S
Thu Aug 27 00:00:00 EDT 2009
SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK.
Blood
Okawa Y,Hideshima T,Steed P,Vallet S,Hall S,Huang K,Rice J,Barabasz A,Foley B,Ikeda H,Raje N,Kiziltepe T,Yasui H,Enatsu S,Anderson KC
Thu Jan 22 00:00:00 EST 2009
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency.
Blood
Sauer AV,Mrak E,Hernandez RJ,Zacchi E,Cavani F,Casiraghi M,Grunebaum E,Roifman CM,Cervi MC,Ambrosi A,Carlucci F,Roncarolo MG,Villa A,Rubinacci A,Aiuti A
Thu Oct 08 00:00:00 EDT 2009
Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease.
Blood
Kukreja A,Radfar S,Sun BH,Insogna K,Dhodapkar MV
Thu Oct 15 00:00:00 EDT 2009
GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme (TACE).
Blood
Hiasa M,Abe M,Nakano A,Oda A,Amou H,Kido S,Takeuchi K,Kagawa K,Yata K,Hashimoto T,Ozaki S,Asaoka K,Tanaka E,Moriyama K,Matsumoto T
Thu Nov 12 00:00:00 EST 2009
A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Fulciniti M,Hideshima T,Vermot-Desroches C,Pozzi S,Nanjappa P,Shen Z,Patel N,Smith ES,Wang W,Prabhala R,Tai YT,Tassone P,Anderson KC,Munshi NC
Tue Dec 01 00:00:00 EST 2009
The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Whyte LS,Ryberg E,Sims NA,Ridge SA,Mackie K,Greasley PJ,Ross RA,Rogers MJ
Tue Sep 22 00:00:00 EDT 2009
The proliferative human monocyte subpopulation contains osteoclast precursors.
Arthritis research & therapy
Lari R,Kitchener PD,Hamilton JA
Wed Sep 09 00:00:00 EDT 2009
GM-CSF regulates fusion of mononuclear osteoclasts into bone-resorbing osteoclasts by activating the Ras/ERK pathway.
Journal of immunology (Baltimore, Md. : 1950)
Lee MS,Kim HS,Yeon JT,Choi SW,Chun CH,Kwak HB,Oh J
Tue Sep 01 00:00:00 EDT 2009
IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression.
Journal of immunology (Baltimore, Md. : 1950)
Park-Min KH,Ji JD,Antoniv T,Reid AC,Silver RB,Humphrey MB,Nakamura M,Ivashkiv LB
Sat Aug 15 00:00:00 EDT 2009
Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis.
The Journal of biological chemistry
Lee Y,Ha J,Kim HJ,Kim YS,Chang EJ,Song WJ,Kim HH
Fri Nov 27 00:00:00 EST 2009
Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling.
The Journal of biological chemistry
Lee JH,Kim HN,Yang D,Jung K,Kim HM,Kim HH,Ha H,Lee ZH
Fri May 15 00:00:00 EDT 2009
Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Barbaroux JB,Beleut M,Brisken C,Mueller CG,Groves RW
Tue Jul 15 00:00:00 EDT 2008
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.
Journal of immunology (Baltimore, Md. : 1950)
Mori Y,Tsuji S,Inui M,Sakamoto Y,Endo S,Ito Y,Fujimura S,Koga T,Nakamura A,Takayanagi H,Itoi E,Takai T
Wed Oct 01 00:00:00 EDT 2008
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.
Journal of immunology (Baltimore, Md. : 1950)
Mori Y,Tsuji S,Inui M,Sakamoto Y,Endo S,Ito Y,Fujimura S,Koga T,Nakamura A,Takayanagi H,Itoi E,Takai T
Wed Oct 01 00:00:00 EDT 2008
Further insights in the mechanisms of interleukin-1beta stimulation of osteoprotegerin in osteoblast-like cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Lambert C,Oury C,Dejardin E,Chariot A,Piette J,Malaise M,Merville MP,Franchimont N
310-01 was used in Cell Culture to investigate mechanisms of IL-1beta stimulation of osteoprotegerin.
Sat Sep 01 00:00:00 EDT 2007
Heparin enhances osteoclastic bone resorption by inhibiting osteoprotegerin activity.
Bone
Irie A,Takami M,Kubo H,Sekino-Suzuki N,Kasahara K,Sanai Y
Wed Aug 01 00:00:00 EDT 2007
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis.
The Journal of biological chemistry
Yang M,Mailhot G,Birnbaum MJ,MacKay CA,Mason-Savas A,Odgren PR
Fri Aug 18 00:00:00 EDT 2006
MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation.
The Journal of biological chemistry
Kim MS,Day CJ,Morrison NA
Fri Apr 22 00:00:00 EDT 2005
MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha.
The Journal of experimental medicine
Sato N,Takahashi N,Suda K,Nakamura M,Yamaki M,Ninomiya T,Kobayashi Y,Takada H,Shibata K,Yamamoto M,Takeda K,Akira S,Noguchi T,Udagawa N
Mon Sep 06 00:00:00 EDT 2004
Possible involvement of MIP-1alpha in the recruitment of osteoclast progenitors to the distal tibia in rats with adjuvant-induced arthritis.
Laboratory investigation; a journal of technical methods and pathology
Toh K,Kukita T,Wu Z,Kukita A,Sandra F,Tang QY,Nomiyama H,Iijima T
Wed Sep 01 00:00:00 EDT 2004
Disabling of receptor activator of nuclear factor-kappaB (RANK) receptor complex by novel osteoprotegerin-like peptidomimetics restores bone loss in vivo.
The Journal of biological chemistry
Cheng X,Kinosaki M,Takami M,Choi Y,Zhang H,Murali R
Fri Feb 27 00:00:00 EST 2004
Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone.
The Journal of clinical investigation
Zhang J,Dai J,Qi Y,Lin DL,Smith P,Strayhorn C,Mizokami A,Fu Z,Westman J,Keller ET
Tue May 01 00:00:00 EDT 2001
Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone.
The Journal of clinical investigation
Zhang J,Dai J,Qi Y,Lin DL,Smith P,Strayhorn C,Mizokami A,Fu Z,Westman J,Keller ET
Tue May 01 00:00:00 EDT 2001
