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Product Details
RP-88178
Product Specifications
Species
Human
Expression System
HEK293 cells
Amino acid sequence
Human ULBP2, amino acids Met1-Ser217 (Accession # Q9BZM5) with a C-terminal His-tag
Tag
His-tag
Molecular weight
33 kDa
Class
Recombinant
Type
Protein
Purity
≥97% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.
Endotoxin concentration
<1.0 EU/µg
Conjugate
Form
Lyophilized
Purification
purified
Storage buffer
PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (900 µL) be added to the vial to prepare a stock solution of 0.25 mg/mL.
Concentration is measured by UV.
Target Information
ULBP2 encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALCAN-alpha; N2DL-2; NKG2D ligand 2; Retinoic acid early transcript 1H; UL16-binding protein 2
Gene Aliases: ALCAN-alpha; N2DL2; NKG2DL2; RAET1H; ULBP2; UNQ463/PRO791
UniProt ID: (Human) Q9BZM5
Entrez Gene ID: (Human) 80328
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