Gibco

Human VEGF-C Recombinant Protein, PeproTech®

Product Details

100-20CD-20UG

Applications

Tested Dilution

Publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 3 publications 3 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species

Human

Published species

Human, Mouse, Rat

Expression System

HEK293 cells

Amino acid sequence

AHYNTEILKS IDNEWRKTQC MPREVCIDVG KEFGVATNTF FKPPCVSVYR CGGCCNSEGL QCMNTSTSYL SKTLFEITVP LSQGPKPVTI SFANHTSCRC MSKLDVYRQV HSIIRR

Molecular weight

26.2 kDa

Class

Recombinant

Type

Protein

Purity

≥ 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to stimulate the proliferation of human microvascular endothelial cells (HMVEC) in low serum conditions.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human VEGF-C is a disulfide-linked homodimeric protein consisting of two 13.5 kDa polypeptide chains of 116 amino acid residues. Due to glycosylation, the protein migrates as a 30.0-33.0 kDa band by SDS-PAGE analysis under non-reducing conditions.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Claudin-3 inhibits tumor-induced lymphangiogenesis via regulating the PI3K signaling pathway in lymphatic endothelial cells.

Scientific reports

Lei N,Cheng Y,Wan J,Blasig R,Li A,Bai Y,Haseloff RF,Blasig IE,Zhu L,Qin Z

100-20CD was used in In vitro experiments to indicate that claudin-3 plays an important role as a signaling molecule in lymphatic endothelial cell activity associated with tumor lymphangiogenesis, which may further contribute to melanoma metastasis.

Wed Oct 19 00:00:00 EDT 2022

Lymphangiogenesis in renal fibrosis arises from macrophages via VEGF-C/VEGFR3-dependent autophagy and polarization.

Cell death & disease

Zhang Y,Zhang C,Li L,Liang X,Cheng P,Li Q,Chang X,Wang K,Huang S,Li Y,Liu Y,Xu G

Thu Jan 21 00:00:00 EST 2021

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.

Cell

Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X

Thu Apr 16 00:00:00 EDT 2020

Peripheral Nerve Single-Cell Analysis Identifies Mesenchymal Ligands that Promote Axonal Growth.

eNeuro

Toma JS,Karamboulas K,Carr MJ,Kolaj A,Yuzwa SA,Mahmud N,Storer MA,Kaplan DR,Miller FD

100-20CD was used in Cell Culture to use single-cell transcriptional profiling to identify ligands made by different injured rodent nerve cell types and combine this with cell-surface mass spectrometry to computationally model potential paracrine interactions with peripheral neurons.

Fri Jun 18 00:00:00 EDT 2021

TGFBIp mediates lymphatic sprouting in corneal lymphangiogenesis.

Journal of cellular and molecular medicine

Lin T,Zhang X,Lu Y,Gong L

Fri Nov 01 00:00:00 EDT 2019

Bioinformatics

Protein Aliases: Flt4 ligand; FLT4 ligand DHM; Flt4-L; Vascular endothelial growth factor C; Vascular endothelial growth factor-related protein; VEGF-C; VEGF3; VRP