Gibco

Mouse CCL22 (MDC) Recombinant Protein, PeproTech®

Mouse CCL22 (MDC) Protein in Functional Assay (Functional)

FIGURE: 1 / 1

Mouse CCL22 (MDC) Protein (250-23-20UG) in Functional

Bioassay analysis of Mouse CCL22 (MDC) Recombinant Protein, PeproTech® (Product # 250-23-1MG).

Product Image Gallery

Product Details

250-23-20UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 12 publications 12 publications

Miscellaneous PubMed (Misc)

View 4 publications 4 publications

Product Specifications

Species

Mouse

Published species

Human, Mouse

Expression System

E. coli

Amino acid sequence

GPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS

Molecular weight

7.8 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to chemoattract murine BW5147.3 cells using a concentration range of 1-30 ng/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

CCL22 may play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Also, it is a chemotactic for monocytes. dendritic cells and natural killer cells. CCL22 is a mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CCL17 in Inflammation and Pain.

Journal of immunology (Baltimore, Md. : 1950)

Lee KM,Jarnicki A,Achuthan A,Fleetwood AJ,Anderson GP,Ellson C,Feeney M,Modis LK,Smith JE,Hamilton JA,Cook A

Wed Jul 01 00:00:00 EDT 2020

Tocilizumab monotherapy uncovered the role of the CCL22/17-CCR4⁺ Treg axis during remission of crescentic glomerulonephritis.

Clinical & translational immunology

Sakai R,Ito M,Yoshimoto K,Chikuma S,Kurasawa T,Kondo T,Suzuki K,Takeuchi T,Amano K,Yoshimura A

Mon Apr 18 00:00:00 EDT 2022

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.

Immunity

Kishore M,Cheung KCP,Fu H,Bonacina F,Wang G,Coe D,Ward EJ,Colamatteo A,Jangani M,Baragetti A,Matarese G,Smith DM,Haas R,Mauro C,Wraith DC,Okkenhaug K,Catapano AL,De Rosa V,Norata GD,Marelli-Berg FM

250-23 was used in In Vitro migration assay using mouse cells.

Tue Nov 21 00:00:00 EST 2017

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.

Immunity

Kishore M,Cheung KCP,Fu H,Bonacina F,Wang G,Coe D,Ward EJ,Colamatteo A,Jangani M,Baragetti A,Matarese G,Smith DM,Haas R,Mauro C,Wraith DC,Okkenhaug K,Catapano AL,De Rosa V,Norata GD,Marelli-Berg FM

250-23 was used in In Vitro migration assay using mouse cells.

Tue Nov 21 00:00:00 EST 2017

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

Scientific reports

Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S

Tue Jun 27 00:00:00 EDT 2017

Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.

Scientific reports

Yagawa Y,Robertson-Tessi M,Zhou SL,Anderson ARA,Mulé JJ,Mailloux AW

Wed Nov 22 00:00:00 EST 2017

Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release.

Immunity

Komarowska I,Coe D,Wang G,Haas R,Mauro C,Kishore M,Cooper D,Nadkarni S,Fu H,Steinbruchel DA,Pitzalis C,Anderson G,Bucy P,Lombardi G,Breckenridge R,Marelli-Berg FM

Tue Jun 16 00:00:00 EDT 2015

CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen.

Journal of immunology (Baltimore, Md. : 1950)

Elgueta R,Marks E,Nowak E,Menezes S,Benson M,Raman VS,Ortiz C,O'Connell S,Hess H,Lord GM,Noelle R

Thu Jan 15 00:00:00 EST 2015

Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes.

Journal of immunology (Baltimore, Md. : 1950)

Ford LB,Cerovic V,Milling SW,Graham GJ,Hansell CA,Nibbs RJ

Tue Jul 01 00:00:00 EDT 2014

Universal expression and dual function of the atypical chemokine receptor D6 on innate-like B cells in mice.

Blood

Hansell CA,Schiering C,Kinstrie R,Ford L,Bordon Y,McInnes IB,Goodyear CS,Nibbs RJ

Thu May 19 00:00:00 EDT 2011

Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1.

Proceedings of the National Academy of Sciences of the United States of America

Dowal L,Sim DS,Dilks JR,Blair P,Beaudry S,Denker BM,Koukos G,Kuliopulos A,Flaumenhaft R

Tue Feb 15 00:00:00 EST 2011

Pan-CC chemokine neutralization restricts splenocyte egress and reduces inflammation in a model of arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Buatois V,Fagète S,Magistrelli G,Chatel L,Fischer N,Kosco-Vilbois MH,Ferlin WG

Sun Aug 15 00:00:00 EDT 2010

Structure and function of A41, a vaccinia virus chemokine binding protein.

PLoS pathogens

Bahar MW,Kenyon JC,Putz MM,Abrescia NG,Pease JE,Wise EL,Stuart DI,Smith GL,Grimes JM

Tue Jan 01 00:00:00 EST 2008

Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling.

Journal of immunology (Baltimore, Md. : 1950)

Mathew A,Medoff BD,Carafone AD,Luster AD

Mon Jul 15 00:00:00 EDT 2002

CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin.

The Journal of experimental medicine

Reiss Y,Proudfoot AE,Power CA,Campbell JJ,Butcher EC

Mon Nov 19 00:00:00 EST 2001

Enhancement of stromal cell-derived factor-1alpha-induced chemotaxis for CD4/8 double-positive thymocytes by fibronectin and laminin in mice.

Immunology

Yanagawa Y,Iwabuchi K,Onoé K

Sat Sep 01 00:00:00 EDT 2001

Bioinformatics

Protein Aliases: Activated B and dendritic cell-derived; AW060611; C-C motif chemokine 22; CC chemokine ABCD-1; dendritic cell and B cell derived chemokine; MGC108943; MGC34554; RP24-69A20.1; SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED); small inducible cytokine subfamily A, member 22; small inducible cytokine subfamily A22; Small-inducible cytokine A22

Mouse CCL22 (MDC) Recombinant Protein, PeproTech®

Mouse CCL22 (MDC) Protein (250-23-20UG) in Functional

Product Details

250-23-20UG

Western Blot (WB)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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