Gibco

Mouse CXCL12 (SDF-1b) Recombinant Protein, PeproTech®

Product Details

250-20B-10UG

Applications

Tested Dilution

Publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 7 publications 7 publications

Miscellaneous PubMed (Misc)

View 5 publications 5 publications

Product Specifications

Species

Mouse

Published species

Human, Mouse

Expression System

E. coli

Amino acid sequence

KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRL KM

Molecular weight

8.5 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to chemoattract human monocytes using a concentration range of 50.0-100.0 ng/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Murine SDF-1beta is an 8.5 kDa protein containing 72 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness.

Leukemia

Lewis R,Maurer HC,Singh N,Gonzalez-Menendez I,Wirth M,Schick M,Zhang L,Isaakidis K,Scherger AK,Schulze V,Lu J,Zenz T,Steiger K,Rad R,Quintanilla-Martinez L,Espeli M,Balabanian K,Keller U,Habringer S

Fri Oct 01 00:00:00 EDT 2021

Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes.

Scientific reports

Cruz-Zárate D,López-Ortega O,Girón-Pérez DA,Gonzalez-Suarez AM,García-Cordero JL,Schnoor M,Santos-Argumedo L

Tue Mar 30 00:00:00 EDT 2021

Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections.

Nature communications

Bénard A,Jacobsen A,Brunner M,Krautz C,Klösch B,Swierzy I,Naschberger E,Podolska MJ,Kouhestani D,David P,Birkholz T,Castellanos I,Trufa D,Sirbu H,Vetter M,Kremer AE,Hildner K,Hecker A,Edinger F,Tenbusch M,Mühl-Zürbes P,Steinkasserer A,Richter E,Streeck H,Berger MM,Brenner T,Weigand MA,Swirski FK,Schett G,Grützmann R,Weber GF

Thu Feb 18 00:00:00 EST 2021

Distinguishing Specific CXCL12 Isoforms on Their Angiogenesis and Vascular Permeability Promoting Properties.

Advanced healthcare materials

Chang CW,Seibel AJ,Avendano A,Cortes-Medina MG,Song JW

Sat Feb 01 00:00:00 EST 2020

PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity.

Cell reports

Lucas ED,Schafer JB,Matsuda J,Kraus M,Burchill MA,Tamburini BAJ

250-20B was used in In vitro experiments to identify a TSS signaling motif within the intracellular domain of PD-L1.

Tue Oct 13 00:00:00 EDT 2020

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

Scientific reports

Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S

Tue Jun 27 00:00:00 EDT 2017

Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.

Scientific reports

Yagawa Y,Robertson-Tessi M,Zhou SL,Anderson ARA,Mulé JJ,Mailloux AW

Wed Nov 22 00:00:00 EST 2017

AML1/ETO accelerates cell migration and impairs cell-to-cell adhesion and homing of hematopoietic stem/progenitor cells.

Scientific reports

Saia M,Termanini A,Rizzi N,Mazza M,Barbieri E,Valli D,Ciana P,Gruszka AM,Alcalay M

Fri Oct 07 00:00:00 EDT 2016

CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen.

Journal of immunology (Baltimore, Md. : 1950)

Elgueta R,Marks E,Nowak E,Menezes S,Benson M,Raman VS,Ortiz C,O'Connell S,Hess H,Lord GM,Noelle R

Thu Jan 15 00:00:00 EST 2015

The HGF receptor/Met tyrosine kinase is a key regulator of dendritic cell migration in skin immunity.

Journal of immunology (Baltimore, Md. : 1950)

Baek JH,Birchmeier C,Zenke M,Hieronymus T

Wed Aug 15 00:00:00 EDT 2012

Structure and function of A41, a vaccinia virus chemokine binding protein.

PLoS pathogens

Bahar MW,Kenyon JC,Putz MM,Abrescia NG,Pease JE,Wise EL,Stuart DI,Smith GL,Grimes JM

Tue Jan 01 00:00:00 EST 2008

Inhibition of gluconeogenesis in primary hepatocytes by stromal cell-derived factor-1 (SDF-1) through a c-Src/Akt-dependent signaling pathway.

The Journal of biological chemistry

Liu HY,Wen GB,Han J,Hong T,Zhuo D,Liu Z,Cao W

Fri Nov 07 00:00:00 EST 2008

Bioinformatics

Protein Aliases: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 12; CC motif chemokine; CCmotif chemokine; CXC; CXC motif chemokine; CXCL; PBSF; Pre-B cell growth-stimulating factor; pre-B-cell growth-stimulating factor; SDF-1; sdf-1 beta; Stromal cell-derived factor 1; Thymic lymphoma cell-stimulating factor; TLSF; TPAR1

Mouse CXCL12 (SDF-1b) Recombinant Protein, PeproTech®

Product Details

250-20B-10UG

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

We're here to help

Your items have has been added!