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Mouse CXCL16 Recombinant Protein, PeproTech®

Mouse CXCL16 Protein in Functional Assay (Functional)

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Mouse CXCL16 Protein (250-28-25UG) in Functional

Bioassay analysis of Mouse CXCL16 Recombinant Protein, PeproTech® (Product # 250-28-1MG).

Product Image Gallery

Product Details

250-28-25UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 14 publications 14 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species

Mouse

Published species

Human, Mouse

Expression System

E. coli

Amino acid sequence

NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP

Molecular weight

9.9 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to chemoattract murine lymphocytes using a concentration of 20-1000 ng/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Murine CXCL16 is a 9.9 kDa protein containing 88 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. CXCL16 may play a role in attracting lymphocyte subsets during inflammation and may facilitate certain immune responses. The chemokine domain of CXCL16 contains six cysteine residues, including the four highly conserved cysteine residues characteristic of CXC chemokines. The CXCL16 gene codes for a 273 amino acid polypeptide, which includes a 29 amino acid cytoplasmic domain and transmembrane sequence containing approximately 20 amino acids. The extracellular portion of CXCL16 contains a chemokines domain and an extended C-terminal mucin-like stalk sequence. The extracellular domain contains 89 amino acid residues (86 a.a. residues for the murine homolog).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH.

Nature

Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA

250-28 was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.

Thu Apr 01 00:00:00 EDT 2021

CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment.

Cell

Di Pilato M,Kfuri-Rubens R,Pruessmann JN,Ozga AJ,Messemaker M,Cadilha BL,Sivakumar R,Cianciaruso C,Warner RD,Marangoni F,Carrizosa E,Lesch S,Billingsley J,Perez-Ramos D,Zavala F,Rheinbay E,Luster AD,Gerner MY,Kobold S,Pittet MJ,Mempel TR

Thu Aug 19 00:00:00 EDT 2021

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.

Nature biomedical engineering

Lesch S,Blumenberg V,Stoiber S,Gottschlich A,Ogonek J,Cadilha BL,Dantes Z,Rataj F,Dorman K,Lutz J,Karches CH,Heise C,Kurzay M,Larimer BM,Grassmann S,Rapp M,Nottebrock A,Kruger S,Tokarew N,Metzger P,Hoerth C,Benmebarek MR,Dhoqina D,Grünmeier R,Seifert M,Oener A,Umut Ö,Joaquina S,Vimeux L,Tran T,Hank T,Baba T,Huynh D,Megens RTA,Janssen KP,Jastroch M,Lamp D,Ruehland S,Di Pilato M,Pruessmann JN,Thomas M,Marr C,Ormanns S,Reischer A,Hristov M,Tartour E,Donnadieu E,Rothenfusser S,Duewell P,König LM,Schnurr M,Subklewe M,Liss AS,Halama N,Reichert M,Mempel TR,Endres S,Kobold S

Mon Nov 01 00:00:00 EDT 2021

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.

Nature biomedical engineering

Mon Nov 01 00:00:00 EDT 2021

Butyrate induced Tregs are capable of migration from the GALT to the pancreas to restore immunological tolerance during type-1 diabetes.

Scientific reports

Jacob N,Jaiswal S,Maheshwari D,Nallabelli N,Khatri N,Bhatia A,Bal A,Malik V,Verma S,Kumar R,Sachdeva N

Thu Nov 05 00:00:00 EST 2020

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

Scientific reports

Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S

Tue Jun 27 00:00:00 EDT 2017

Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.

Scientific reports

Yagawa Y,Robertson-Tessi M,Zhou SL,Anderson ARA,Mulé JJ,Mailloux AW

Wed Nov 22 00:00:00 EST 2017

The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area.

Scientific reports

Di Castro MA,Trettel F,Milior G,Maggi L,Ragozzino D,Limatola C

Mon Oct 10 00:00:00 EDT 2016

KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages.

Cell death & disease

Grimaldi A,D'Alessandro G,Golia MT,Grössinger EM,Di Angelantonio S,Ragozzino D,Santoro A,Esposito V,Wulff H,Catalano M,Limatola C

Thu Apr 07 00:00:00 EDT 2016

IL-27 receptor signaling regulates CD4+ T cell chemotactic responses during infection.

Journal of immunology (Baltimore, Md. : 1950)

Gwyer Findlay E,Villegas-Mendez A,de Souza JB,Inkson CA,Shaw TN,Saris CJ,Hunter CA,Riley EM,Couper KN

Wed May 01 00:00:00 EDT 2013

Aurintricarboxylic acid ameliorates experimental autoimmune encephalomyelitis by blocking chemokine-mediated pathogenic cell migration and infiltration.

Journal of immunology (Baltimore, Md. : 1950)

Zhang F,Wei W,Chai H,Xie X

Fri Feb 01 00:00:00 EST 2013

Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects.

The Journal of clinical investigation

Ruocco MG,Pilones KA,Kawashima N,Cammer M,Huang J,Babb JS,Liu M,Formenti SC,Dustin ML,Demaria S

Mon Oct 01 00:00:00 EDT 2012

Chemokines and inflammatory mediators interact to regulate adult murine neural precursor cell proliferation, survival and differentiation.

PloS one

Turbic A,Leong SY,Turnley AM

Fri Feb 10 00:00:00 EST 2012

Mesenchymal stem cells exhibit firm adhesion, crawling, spreading and transmigration across aortic endothelial cells: effects of chemokines and shear.

PloS one

Chamberlain G,Smith H,Rainger GE,Middleton J

Thu Jan 26 00:00:00 EST 2012

Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells.

Journal of immunology (Baltimore, Md. : 1950)

Matsumura S,Wang B,Kawashima N,Braunstein S,Badura M,Cameron TO,Babb JS,Schneider RJ,Formenti SC,Dustin ML,Demaria S

Mon Sep 01 00:00:00 EDT 2008

Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells.

Journal of immunology (Baltimore, Md. : 1950)

Shimaoka T,Seino K,Kume N,Minami M,Nishime C,Suematsu M,Kita T,Taniguchi M,Matsushima K,Yonehara S

Sat Dec 15 00:00:00 EST 2007

Bioinformatics

Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 16; CC motif chemokine; CCmotif chemokine; CXC; Cxc chemokine ligand 16; CXC motif chemokine; CXCL; Mutant line 498; Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; Small-inducible cytokine B16; SR-PSOX; SR-PSOX/CXCL16; Transmembrane chemokine CXCL16; zinc finger, MYND-type containing 15

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Gene Aliases: 0910001K24Rik; AV290116; b2b498Clo; BB024863; Cxcl16; CXCL16v1; CXCL16v2; SR-PSOX; Srpsox; Zmynd15

Mouse CXCL16 Recombinant Protein, PeproTech®

Mouse CXCL16 Protein (250-28-25UG) in Functional

Product Details

250-28-25UG

Western Blot (WB)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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