Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (650 µL) be added to the vial to prepare a stock solution of 1.54 mg/mL.
Concentration is measured by UV.
DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dickkopf-1; dickkopf-like protein 1; Dickkopf-related protein 1; Dickkopf1; dkk-1; hDkk1
Gene Aliases: Dkk1; mdkk-1
UniProt ID: (Mouse) O54908
Entrez Gene ID: (Mouse) 13380
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