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Product Details
450-57-25UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Mouse
Published species
Mouse
Expression System
E. coli
Amino acid sequence
APNGTRHAEL GHGWDGLVAR SLARLPVAAQ PPQAAVRSGA GDYLLGLKRL RRLYCNVGIG FHLQVLPDGR IGGVHADTRD SLLELSPVQR GVVSIFGVAS RFFVAMSSRG KLFGVPFFTD ECKFKEILLP NNYNAYESYA YPGMFMALSK NGRTKKGNRV SPTMKVTHFL PRL
Molecular weight
19 kDa
Class
Recombinant
Type
Protein
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 0.4-1.0 ng/ml.
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
450-57-1MG will be provided as 2 x 500 µg (450-57-500UG).
Recombinant Murine FGF-4 is a 19.0 kDa protein consisting of 173 amino acid residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family that possess broad mitogenic and cell survival activities and play key roles in growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis. FGF4 was identified by its strong oncogenic transforming activity and is a potent angiogenic factor, expressed in several highly vascularized tumors and also in adult mouse testis, intestine, and brain. Studies on the mouse homolog suggests a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Furthermore, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation. Recent studies show a growth-promoting role for FGF4 in human embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at a later stages of development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FGF; FGF-4; Fibroblast growth factor; Fibroblast growth factor 4; HBGF-4; Heparin-binding growth factor 4; K-fibroblast growth factor
Gene Aliases: Fgf-4; Fgf4; Fgfk; hst; hst-1; Hst1; Hstf-1; Kfgf; KS3
UniProt ID: (Mouse) P11403
Entrez Gene ID: (Mouse) 14175
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