Gibco

Mouse FGF-9 Recombinant Protein, PeproTech®

Product Details

450-30-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

View 1 publication 1 publication

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 21 publications 21 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species

Mouse

Published species

Mouse, Rat

Expression System

E. coli

Amino acid sequence

PLGEVGSYFG VQDAVPFGNV PVLPVDSPVL LNDHLGQSEA GGLPRGPAVT DLDHLKGILR RRQLYCRTGF HLEIFPNGTI QGTRKDHSRF GILEFISIAV GLVSIRGVDS GLYLGMNEKG ELYGSEKLTQ ECVFREQFEE NWYNTYSSNL YKHVDTGRRY YVALNKDGTP REGTRTKRHQ KFTHFLPRPV DPDKVPELYK DILSQS

Molecular weight

23.3 kDa

Class

Recombinant

Type

Protein

Purity

≥ 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 10 ng/ml, corresponding to a specific activity of ≥ 1 x 10^5 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

450-30-1MG will be provided as 2 x 500 µg (450-30-500UG).

Recombinant Murine FGF-9 is a 23.3 kDa protein containing 206 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells.

Communications biology

Rore H,Owen N,Piña-Aguilar RE,Docherty K,Sekido R

Mon Jun 28 00:00:00 EDT 2021

3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis.

Frontiers in cell and developmental biology

Rabata A,Fedr R,Soucek K,Hampl A,Koledova Z

450-30 was used in Tissue/organ culture to present lung 3D cell culture models as useful tools to study the role and interplay of signaling pathways in postnatal lung development and homeostasis, and we reveal distinct roles for FGF ligands in regulation of mouse lung morphogenesis and differentiation ex vivo.

Mon Sep 28 00:00:00 EDT 2020

Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes.

Scientific reports

Westphal S,Gantert T,Kless C,Hüttinger K,Klingenspor M,Fromme T

Tue Jun 11 00:00:00 EDT 2019

Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.

Nature communications

Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA

Mon Jun 04 00:00:00 EDT 2018

Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.

Nature communications

Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA

Mon Jun 04 00:00:00 EDT 2018

The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells.

PloS one

Takeichi M,Nimura K,Mori M,Nakagami H,Kaneda Y

Thu Aug 29 00:00:00 EDT 2013

FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.

Developmental cell

Barak H,Huh SH,Chen S,Jeanpierre C,Martinovic J,Parisot M,Bole-Feysot C,Nitschké P,Salomon R,Antignac C,Ornitz DM,Kopan R

Tue Jun 12 00:00:00 EDT 2012

Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal.

PLoS biology

Huh SH,Jones J,Warchol ME,Ornitz DM

Sun Jan 01 00:00:00 EST 2012

FGF-9 accelerates epithelial invagination for ectodermal organogenesis in real time bioengineered organ manipulation.

Cell communication and signaling : CCS

Tai YY,Chen RS,Lin Y,Ling TY,Chen MH

Fri Nov 23 00:00:00 EST 2012

FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium.

Development (Cambridge, England)

Vega-Hernández M,Kovacs A,De Langhe S,Ornitz DM

Mon Aug 01 00:00:00 EDT 2011

FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wöhrle S,Bonny O,Beluch N,Gaulis S,Stamm C,Scheibler M,Müller M,Kinzel B,Thuery A,Brueggen J,Hynes NE,Sellers WR,Hofmann F,Graus-Porta D

Sat Oct 01 00:00:00 EDT 2011

HuR controls lung branching morphogenesis and mesenchymal FGF networks.

Developmental biology

Sgantzis N,Yiakouvaki A,Remboutsika E,Kontoyiannis DL

Wed Jun 15 00:00:00 EDT 2011

Growth factor regulation of prostaglandin-endoperoxide synthase 2 (Ptgs2) expression in colonic mesenchymal stem cells.

The Journal of biological chemistry

Walker MR,Brown SL,Riehl TE,Stenson WF,Stappenbeck TS

Fri Feb 12 00:00:00 EST 2010

Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors.

Nature neuroscience

Seuntjens E,Nityanandam A,Miquelajauregui A,Debruyn J,Stryjewska A,Goebbels S,Nave KA,Huylebroeck D,Tarabykin V

Sun Nov 01 00:00:00 EDT 2009

Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung.

Developmental dynamics : an official publication of the American Association of Anatomists

Yi L,Domyan ET,Lewandoski M,Sun X

Thu Jan 01 00:00:00 EST 2009

An FGF-WNT gene regulatory network controls lung mesenchyme development.

Developmental biology

Yin Y,White AC,Huh SH,Hilton MJ,Kanazawa H,Long F,Ornitz DM

Tue Jul 15 00:00:00 EDT 2008

FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network.

Development (Cambridge, England)

White AC,Lavine KJ,Ornitz DM

Mon Oct 01 00:00:00 EDT 2007

FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod.

Developmental biology

Hung IH,Yu K,Lavine KJ,Ornitz DM

Sun Jul 15 00:00:00 EDT 2007

Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development.

Genes & development

Lavine KJ,White AC,Park C,Smith CS,Choi K,Long F,Hui CC,Ornitz DM

Thu Jun 15 00:00:00 EDT 2006

FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains.

Development (Cambridge, England)

White AC,Xu J,Yin Y,Smith C,Schmid G,Ornitz DM

Sat Apr 01 00:00:00 EST 2006

Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development.

Development (Cambridge, England)

Zhang X,Stappenbeck TS,White AC,Lavine KJ,Gordon JI,Ornitz DM

Sun Jan 01 00:00:00 EST 2006

BMP4 modulates fibroblast growth factor-mediated induction of proximal and distal lung differentiation in mouse embryonic tracheal epithelium in mesenchyme-free culture.

Developmental dynamics : an official publication of the American Association of Anatomists

Hyatt BA,Shangguan X,Shannon JM

Tue Oct 01 00:00:00 EDT 2002

Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity.

The Journal of biological chemistry

Chellaiah A,Yuan W,Chellaiah M,Ornitz DM

Fri Dec 03 00:00:00 EST 1999

Expression and biological activity of mouse fibroblast growth factor-9.

The Journal of biological chemistry

Santos-Ocampo S,Colvin JS,Chellaiah A,Ornitz DM

Fri Jan 19 00:00:00 EST 1996

Bioinformatics

Protein Aliases: elbow knee synostosis; FGF; FGF-9; Fibroblast growth factor; Fibroblast growth factor 9; GAF; glia activating factor; Glia-activating factor; HBGF-9; M-FGF-9

Mouse FGF-9 Recombinant Protein, PeproTech®

Product Details

450-30-10UG

Western Blot (WB)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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