Product References
The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability.
Blood
Tu Z,Wang C,Davis AK,Hu M,Zhao C,Xin M,Lu QR,Zheng Y
Thu Jul 22 00:00:00 EDT 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Mon Jul 05 00:00:00 EDT 2021
The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.
The Journal of experimental medicine
Stamos DB,Clubb LM,Mitra A,Chopp LB,Nie J,Ding Y,Das A,Venkataganesh H,Lee J,El-Khoury D,Li L,Bhandoola A,Bosselut R,Love PE
Mon Dec 06 00:00:00 EST 2021
Intranasal mesenchymal stem cell therapy to boost myelination after encephalopathy of prematurity.
Glia
Vaes JEG,van Kammen CM,Trayford C,van der Toorn A,Ruhwedel T,Benders MJNL,Dijkhuizen RM,Möbius W,van Rijt SH,Nijboer CH
250-05 was used in Cell Culture to show that MSCs adapt their secretome after ex vivo exposure to dWMI milieu and identified several factors including IGF1, EGF, LIF, and IL11 that potently boost OL maturation.
Mon Mar 01 00:00:00 EST 2021
Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.
iScience
AbuEid M,McAllister DM,McOlash L,Harwig MC,Cheng G,Drouillard D,Boyle KA,Hardy M,Zielonka J,Johnson BD,Hill RB,Kalyanaraman B,Dwinell MB
Fri Jun 25 00:00:00 EDT 2021
MEK inhibition exerts temporal and myeloid cell-specific effects in the pathogenesis of neurofibromatosis type 1 arteriopathy.
Scientific reports
Tritz R,Hudson FZ,Harris V,Ghoshal P,Singla B,Lin H,Csanyi G,Stansfield BK
Tue Dec 21 00:00:00 EST 2021
Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis.
Nature communications
Wang X,Hu LP,Qin WT,Yang Q,Chen DY,Li Q,Zhou KX,Huang PQ,Xu CJ,Li J,Yao LL,Wang YH,Tian GA,Yang JY,Yang MW,Liu DJ,Sun YW,Jiang SH,Zhang XL,Zhang ZG
Fri Jan 08 00:00:00 EST 2021
IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints.
Proceedings of the National Academy of Sciences of the United States of America
Panda SK,Wigerblad G,Jiang L,Jiménez-Andrade Y,Iyer VS,Shen Y,Boddul SV,Guerreiro-Cacais AO,Raposo B,Kasza Z,Wermeling F
Tue Feb 11 00:00:00 EST 2020
CD62Ldim Neutrophils Specifically Migrate to the Lung and Participate in the Formation of the Pre-Metastatic Niche of Breast Cancer.
Frontiers in oncology
Wang Z,Yang C,Li L,Zhang Z,Pan J,Su K,Chen W,Li J,Qiu F,Huang J
250-05 was used in In vivo experiments to examine the critical time of the niche formation and detect a novel subset of CD62Ldim neutrophils.
Fri Nov 13 00:00:00 EST 2020
The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Greenberg ZJ,Monlish DA,Bartnett RL,Yang Y,Shen G,Li W,Bednarski JJ,Schuettpelz LG
Wed Jan 01 00:00:00 EST 2020
Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Kralova J,Drobek A,Prochazka J,Spoutil F,Fabisik M,Glatzova D,Borna S,Pokorna J,Skopcova T,Angelisova P,Gregor M,Kovarik P,Sedlacek R,Brdicka T
Sun Mar 15 00:00:00 EDT 2020
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Journal of immunology (Baltimore, Md. : 1950)
Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D
Thu Oct 15 00:00:00 EDT 2020
Lentiviral gene therapy rescues p47phox chronic granulomatous disease and the ability to fight Salmonella infection in mice.
Gene therapy
Schejtman A,Aragão-Filho WC,Clare S,Zinicola M,Weisser M,Burns SO,Booth C,Gaspar HB,Thomas DC,Condino-Neto A,Thrasher AJ,Santilli G
Tue Sep 01 00:00:00 EDT 2020
G-CSF Inhibits Pulmonary Fibrosis by Promoting BMSC Homing to the Lungs via SDF-1/CXCR4 Chemotaxis.
Scientific reports
Zhao FY,Cheng TY,Yang L,Huang YH,Li C,Han JZ,Li XH,Fang LJ,Feng DD,Tang YT,Yue SJ,Tang SY,Luo ZQ,Liu W
Mon Jun 29 00:00:00 EDT 2020
MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia.
Nature communications
Itskovich SS,Gurunathan A,Clark J,Burwinkel M,Wunderlich M,Berger MR,Kulkarni A,Chetal K,Venkatasubramanian M,Salomonis N,Kumar AR,Lee LH
Tue May 12 00:00:00 EDT 2020
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Cell
Ponzetta A,Carriero R,Carnevale S,Barbagallo M,Molgora M,Perucchini C,Magrini E,Gianni F,Kunderfranco P,Polentarutti N,Pasqualini F,Di Marco S,Supino D,Peano C,Cananzi F,Colombo P,Pilotti S,Alomar SY,Bonavita E,Galdiero MR,Garlanda C,Mantovani A,Jaillon S
Thu Jul 11 00:00:00 EDT 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
250-05 was used in Cell Culture to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 EDT 2019
G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche.
The Journal of clinical investigation
Li Z,Hardij J,Evers SS,Hutch CR,Choi SM,Shao Y,Learman BS,Lewis KT,Schill RL,Mori H,Bagchi DP,Romanelli SM,Kim KS,Bowers E,Griffin C,Seeley RJ,Singer K,Sandoval DA,Rosen CJ,MacDougald OA
Mon May 06 00:00:00 EDT 2019
Type I interferon induces CXCL13 to support ectopic germinal center formation.
The Journal of experimental medicine
Denton AE,Innocentin S,Carr EJ,Bradford BM,Lafouresse F,Mabbott NA,Mörbe U,Ludewig B,Groom JR,Good-Jacobson KL,Linterman MA
Mon Mar 04 00:00:00 EST 2019
Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.
The Journal of experimental medicine
Weckbach LT,Grabmaier U,Uhl A,Gess S,Boehm F,Zehrer A,Pick R,Salvermoser M,Czermak T,Pircher J,Sorrelle N,Migliorini M,Strickland DK,Klingel K,Brinkmann V,Abu Abed U,Eriksson U,Massberg S,Brunner S,Walzog B
250-05 was used in Cell Culture to report the presence of neutrophil extracellular traps in cardiac tissue of patients and mice with myocarditis.
Mon Feb 04 00:00:00 EST 2019
Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.
The Journal of experimental medicine
Weckbach LT,Grabmaier U,Uhl A,Gess S,Boehm F,Zehrer A,Pick R,Salvermoser M,Czermak T,Pircher J,Sorrelle N,Migliorini M,Strickland DK,Klingel K,Brinkmann V,Abu Abed U,Eriksson U,Massberg S,Brunner S,Walzog B
250-05 was used in Cell Culture to report the presence of neutrophil extracellular traps in cardiac tissue of patients and mice with myocarditis.
Mon Feb 04 00:00:00 EST 2019
Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs.
The Journal of experimental medicine
Mastio J,Condamine T,Dominguez G,Kossenkov AV,Donthireddy L,Veglia F,Lin C,Wang F,Fu S,Zhou J,Viatour P,Lavilla-Alonso S,Polo AT,Tcyganov EN,Mulligan C,Nam B,Bennett J,Masters G,Guarino M,Kumar A,Nefedova Y,Vonderheide RH,Languino LR,Abrams SI,Gabrilovich DI
Mon Sep 02 00:00:00 EDT 2019
Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.
Genes & development
Labi V,Peng S,Klironomos F,Munschauer M,Kastelic N,Chakraborty T,Schoeler K,Derudder E,Martella M,Mastrobuoni G,Hernandez-Miranda LR,Lahmann I,Kocks C,Birchmeier C,Kempa S,Quintanilla-Martinez de Fend L,Landthaler M,Rajewsky N,Rajewsky K
250-05 was used in Cell Culture to conclude that the interaction of miR-17∼92 with a single target is essential for life, and BIM regulation by miRNAs serves as a rheostat controlling cell survival in specific physiological contexts.
Sun Dec 01 00:00:00 EST 2019
Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging.
Aging cell
Yue S,Zheng X,Zheng Y
Thu Aug 01 00:00:00 EDT 2019
Signaling and functional competency of neutrophils derived from bone-marrow cells expressing the ER-HOXB8 oncoprotein.
Journal of leukocyte biology
Saul S,Castelbou C,Fickentscher C,Demaurex N
Fri Nov 01 00:00:00 EDT 2019
IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3.
Immunology and cell biology
McCarthy PC,Phair IR,Greger C,Pardali K,McGuire VA,Clark AR,Gaestel M,Arthur JSC
Tue Jan 01 00:00:00 EST 2019
The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.
Nature communications
Nayak RC,Hegde S,Althoff MJ,Wellendorf AM,Mohmoud F,Perentesis J,Reina-Campos M,Reynaud D,Zheng Y,Diaz-Meco MT,Moscat J,Cancelas JA
Fri Jan 04 00:00:00 EST 2019
Population snapshots predict early haematopoietic and erythroid hierarchies.
Nature
Tusi BK,Wolock SL,Weinreb C,Hwang Y,Hidalgo D,Zilionis R,Waisman A,Huh JR,Klein AM,Socolovsky M
250-05 was used in Cell Culture to illustrate the utility of coupling population snapshots with predictive fate models, to gain in vivo insights of early hempatopoetic and erythroid lineage sorting.
Thu Mar 01 00:00:00 EST 2018
Population snapshots predict early haematopoietic and erythroid hierarchies.
Nature
Tusi BK,Wolock SL,Weinreb C,Hwang Y,Hidalgo D,Zilionis R,Waisman A,Huh JR,Klein AM,Socolovsky M
250-05 was used in Cell Culture to illustrate the utility of coupling population snapshots with predictive fate models, to gain in vivo insights of early hempatopoetic and erythroid lineage sorting.
Thu Mar 01 00:00:00 EST 2018
Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.
Cell
Minzel W,Venkatachalam A,Fink A,Hung E,Brachya G,Burstain I,Shaham M,Rivlin A,Omer I,Zinger A,Elias S,Winter E,Erdman PE,Sullivan RW,Fung L,Mercurio F,Li D,Vacca J,Kaushansky N,Shlush L,Oren M,Levine R,Pikarsky E,Snir-Alkalay I,Ben-Neriah Y
Thu Sep 20 00:00:00 EDT 2018
Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.
The Journal of clinical investigation
Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML
Fri Jun 01 00:00:00 EDT 2018
Altered compensatory cytokine signaling underlies the discrepancy between and mice.
The Journal of experimental medicine
Durai V,Bagadia P,Briseño CG,Theisen DJ,Iwata A,Davidson JT,Gargaro M,Fremont DH,Murphy TL,Murphy KM
Mon May 07 00:00:00 EDT 2018
Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.
The Journal of experimental medicine
Jensen CT,Åhsberg J,Sommarin MNE,Strid T,Somasundaram R,Okuyama K,Ungerbäck J,Kupari J,Airaksinen MS,Lang S,Bryder D,Soneji S,Karlsson G,Sigvardsson M
Mon Jul 02 00:00:00 EDT 2018
Intestinal host defense outcome is dictated by PGE2 production during efferocytosis of infected cells.
Proceedings of the National Academy of Sciences of the United States of America
Dejani NN,Orlando AB,Niño VE,Penteado LA,Verdan FF,Bazzano JMR,Codo AC,Salina ACG,Saraiva AC,Avelar MR,Spolidorio LC,Serezani CH,Medeiros AI
Tue Sep 04 00:00:00 EDT 2018
Autocrine IL-10 Signaling Promotes Dendritic Cell Type-2 Activation and Persistence of Murine Cryptococcal Lung Infection.
Journal of immunology (Baltimore, Md. : 1950)
Teitz-Tennenbaum S,Viglianti SP,Roussey JA,Levitz SM,Olszewski MA,Osterholzer JJ
Mon Oct 01 00:00:00 EDT 2018
Toxic adjuvants alter the function and phenotype of dendritic cells to initiate adaptive immune responses induced by oral Helicobacter pylori vaccines.
Helicobacter
Luo S,Liu W,Zeng Z,Ye F,Hu C,Xu N,Huang A,Xi T,Xing Y
Sat Dec 01 00:00:00 EST 2018
Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells.
Scientific reports
Rodrigues CFD,Serrano E,Patrício MI,Val MM,Albuquerque P,Fonseca J,Gomes CMF,Abrunhosa AJ,Paiva A,Carvalho L,Botelho MF,Almeida L,Carreira IM,Alpoim MC
Wed Aug 01 00:00:00 EDT 2018
Chlamydial Plasmid-Encoded Protein pGP3 Inhibits Development of Psoriasis-Like Lesions in Mice.
Medical science monitor : international medical journal of experimental and clinical research
Hou S,Xu R,Zhu C,Shan S,Han L,Wang H
250-05 was used in In vitro experiments to study the role of pGP3 in the development of lesions in mice with imiquimod-induced psoriasis.
Wed Jul 25 00:00:00 EDT 2018
Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease.
Scientific reports
Nakamura J,Watanabe S,Kimura H,Kobayashi M,Karasawa T,Kamata R,Usui-Kawanishi F,Sadatomo A,Mizukami H,Nagi-Miura N,Ohno N,Kasahara T,Minota S,Takahashi M
Tue May 15 00:00:00 EDT 2018
Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation.
Immunity
Riffelmacher T,Clarke A,Richter FC,Stranks A,Pandey S,Danielli S,Hublitz P,Yu Z,Johnson E,Schwerd T,McCullagh J,Uhlig H,Jacobsen SEW,Simon AK
Tue Sep 19 00:00:00 EDT 2017
Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.
Cancer cell
Gu Y,Zhang J,Ma X,Kim BW,Wang H,Li J,Pan Y,Xu Y,Ding L,Yang L,Guo C,Wu X,Wu J,Wu K,Gan X,Li G,Li L,Forman SJ,Chan WC,Xu R,Huang W
Mon Jul 10 00:00:00 EDT 2017
BCAP inhibits proliferation and differentiation of myeloid progenitors in the steady state and during demand situations.
Blood
Duggan JM,Buechler MB,Olson RM,Hohl TM,Hamerman JA
Thu Mar 16 00:00:00 EDT 2017
Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.
The Journal of experimental medicine
Karmaus PWF,Herrada AA,Guy C,Neale G,Dhungana Y,Long L,Vogel P,Avila J,Clish CB,Chi H
Mon Sep 04 00:00:00 EDT 2017
The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production.
Journal of immunology (Baltimore, Md. : 1950)
Netherby CS,Messmer MN,Burkard-Mandel L,Colligan S,Miller A,Cortes Gomez E,Wang J,Nemeth MJ,Abrams SI
Mon May 15 00:00:00 EDT 2017
The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production.
Journal of immunology (Baltimore, Md. : 1950)
Netherby CS,Messmer MN,Burkard-Mandel L,Colligan S,Miller A,Cortes Gomez E,Wang J,Nemeth MJ,Abrams SI
Mon May 15 00:00:00 EDT 2017
Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2.
Scientific reports
MacNicol MC,Cragle CE,McDaniel FK,Hardy LL,Wang Y,Arumugam K,Rahmatallah Y,Glazko GV,Wilczynska A,Childs GV,Zhou D,MacNicol AM
Thu Sep 14 00:00:00 EDT 2017
High-dose dexamethasone corrects impaired myeloid-derived suppressor cell function via Ets1 in immune thrombocytopenia.
Blood
Hou Y,Feng Q,Xu M,Li GS,Liu XN,Sheng Z,Zhou H,Ma J,Wei Y,Sun YX,Yu YY,Qiu JH,Shao LL,Liu XG,Hou M,Peng J
Thu Mar 24 00:00:00 EDT 2016
Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice.
Journal of immunology (Baltimore, Md. : 1950)
Niu S,Bian Z,Tremblay A,Luo Y,Kidder K,Mansour A,Zen K,Liu Y
Sat Oct 15 00:00:00 EDT 2016
Cooperative Activity of GABP with PU.1 or C/EBPε Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation.
Journal of immunology (Baltimore, Md. : 1950)
Malu K,Garhwal R,Pelletier MG,Gotur D,Halene S,Zwerger M,Yang ZF,Rosmarin AG,Gaines P
Mon Aug 01 00:00:00 EDT 2016
Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950)
Matsumura K,Iwai H,Kato-Miyazawa M,Kirikae F,Zhao J,Yanagawa T,Ishii T,Miyoshi-Akiyama T,Funatogawa K,Kirikae T
Sat Oct 15 00:00:00 EDT 2016
RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.
Blood cancer journal
Chin DW,Sakurai M,Nah GS,Du L,Jacob B,Yokomizo T,Matsumura T,Suda T,Huang G,Fu XY,Ito Y,Nakajima H,Osato M
Fri Jan 08 00:00:00 EST 2016
RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.
Blood cancer journal
Chin DW,Sakurai M,Nah GS,Du L,Jacob B,Yokomizo T,Matsumura T,Suda T,Huang G,Fu XY,Ito Y,Nakajima H,Osato M
Fri Jan 08 00:00:00 EST 2016
Impaired Mobilization of Vascular Reparative Bone Marrow Cells in Streptozotocin-Induced Diabetes but not in Leptin Receptor-Deficient db/db Mice.
Scientific reports
Vasam G,Joshi S,Jarajapu YP
Wed May 18 00:00:00 EDT 2016
IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis.
Nature
Coffelt SB,Kersten K,Doornebal CW,Weiden J,Vrijland K,Hau CS,Verstegen NJM,Ciampricotti M,Hawinkels LJAC,Jonkers J,de Visser KE
Thu Jun 18 00:00:00 EDT 2015
In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity.
Blood
Messmann JJ,Reisser T,Leithäuser F,Lutz MB,Debatin KM,Strauss G
Thu Aug 27 00:00:00 EDT 2015
IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.
Blood
Yáñez A,Ng MY,Hassanzadeh-Kiabi N,Goodridge HS
Thu Feb 26 00:00:00 EST 2015
Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils.
Proceedings of the National Academy of Sciences of the United States of America
Casbon AJ,Reynaud D,Park C,Khuc E,Gan DD,Schepers K,Passegué E,Werb Z
Tue Feb 10 00:00:00 EST 2015
The orphan nuclear receptor NR4A1 specifies a distinct subpopulation of quiescent myeloid-biased long-term HSCs.
Stem cells (Dayton, Ohio)
Land RH,Rayne AK,Vanderbeck AN,Barlowe TS,Manjunath S,Gross M,Eiger S,Klein PS,Cunningham NR,Huang J,Emerson SG,Punt JA
Thu Jan 01 00:00:00 EST 2015
Severe neutrophil-dominated inflammation and enhanced myelopoiesis in IL-33-overexpressing CMV/IL33 mice.
Journal of immunology (Baltimore, Md. : 1950)
Talabot-Ayer D,Martin P,Vesin C,Seemayer CA,Vigne S,Gabay C,Palmer G
Thu Jan 15 00:00:00 EST 2015
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
Nature communications
Lawlor KE,Khan N,Mildenhall A,Gerlic M,Croker BA,D'Cruz AA,Hall C,Kaur Spall S,Anderton H,Masters SL,Rashidi M,Wicks IP,Alexander WS,Mitsuuchi Y,Benetatos CA,Condon SM,Wong WW,Silke J,Vaux DL,Vince JE
Wed Feb 18 00:00:00 EST 2015
Uric acid enhances the antitumor immunity of dendritic cell-based vaccine.
Scientific reports
Wang Y,Ma X,Su C,Peng B,Du J,Jia H,Luo M,Fang C,Wei Y
Tue Nov 10 00:00:00 EST 2015
Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3.
Cell
Betschinger J,Nichols J,Dietmann S,Corrin PD,Paddison PJ,Smith A
Thu Apr 11 00:00:00 EDT 2013
miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis.
Immunity
Sonda N,Simonato F,Peranzoni E,Calì B,Bortoluzzi S,Bisognin A,Wang E,Marincola FM,Naldini L,Gentner B,Trautwein C,Sackett SD,Zanovello P,Molon B,Bronte V
Thu Jun 27 00:00:00 EDT 2013
Runx3 deficiency results in myeloproliferative disorder in aged mice.
Blood
Wang CQ,Motoda L,Satake M,Ito Y,Taniuchi I,Tergaonkar V,Osato M
Thu Jul 25 00:00:00 EDT 2013
Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk.
The Journal of clinical investigation
Staser K,Park SJ,Rhodes SD,Zeng Y,He YZ,Shew MA,Gehlhausen JR,Cerabona D,Menon K,Chen S,Sun Z,Yuan J,Ingram DA,Nalepa G,Yang FC,Clapp DW
Tue Jan 01 00:00:00 EST 2013
Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis.
The Journal of clinical investigation
Waight JD,Netherby C,Hensen ML,Miller A,Hu Q,Liu S,Bogner PN,Farren MR,Lee KP,Liu K,Abrams SI
Tue Oct 01 00:00:00 EDT 2013
Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity.
Blood cancer journal
Pannucci NL,Li D,Sahay S,Thomas EK,Chen R,Tala I,Hu T,Ciccarelli BT,Megjugorac NJ,Adams Iii HC,Rodriguez PL,Fitzpatrick ER,Lagunoff D,Williams DA,Whitehead IP
Fri Aug 16 00:00:00 EDT 2013
Mesenchymal stem cells are mobilized from the bone marrow during inflammation.
Frontiers in immunology
Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE
Wed Mar 06 00:00:00 EST 2013
Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs.
The Journal of cell biology
Liou GY,Döppler H,Necela B,Krishna M,Crawford HC,Raimondo M,Storz P
Mon Aug 05 00:00:00 EDT 2013
Runx1 deficiency permits granulocyte lineage commitment but impairs subsequent maturation.
Oncogenesis
Ng KP,Hu Z,Ebrahem Q,Negrotto S,Lausen J,Saunthararajah Y
Mon Nov 04 00:00:00 EST 2013
Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections.
Journal of immunology (Baltimore, Md. : 1950)
Liu Z,Petersen R,Devireddy L
Wed May 01 00:00:00 EDT 2013
CD47 deficiency does not impede polymorphonuclear neutrophil transmigration but attenuates granulopoiesis at the postacute stage of colitis.
Journal of immunology (Baltimore, Md. : 1950)
Bian Z,Guo Y,Luo Y,Tremblay A,Zhang X,Dharma S,Mishra A,Liu Y
Tue Jan 01 00:00:00 EST 2013
IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation.
Journal of immunology (Baltimore, Md. : 1950)
Yan B,Wei JJ,Yuan Y,Sun R,Li D,Luo J,Liao SJ,Zhou YH,Shu Y,Wang Q,Zhang GM,Feng ZH
Sat Jun 01 00:00:00 EDT 2013
Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Han S,Jeong AL,Lee S,Park JS,Kim KD,Choi I,Yoon SR,Lee MS,Lim JS,Han SH,Yoon DY,Yang Y
Wed May 01 00:00:00 EDT 2013
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.
PloS one
Fossati-Jimack L,Ling GS,Cortini A,Szajna M,Malik TH,McDonald JU,Pickering MC,Cook HT,Taylor PR,Botto M
Fri Sep 27 00:00:00 EDT 2013
Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.
The Journal of biological chemistry
Åhsberg J,Ungerbäck J,Strid T,Welinder E,Stjernberg J,Larsson M,Qian H,Sigvardsson M
Fri Nov 15 00:00:00 EST 2013
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
Thu Feb 09 00:00:00 EST 2012
Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.
Blood
Ottina E,Grespi F,Tischner D,Soratroi C,Geley S,Ploner A,Reichardt HM,Villunger A,Herold MJ
Thu Jun 21 00:00:00 EDT 2012
Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.
Blood
Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC
Thu Oct 11 00:00:00 EDT 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
Mon Jun 04 00:00:00 EDT 2012
Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Xu LS,Sokalski KM,Hotke K,Christie DA,Zarnett O,Piskorz J,Thillainadesan G,Torchia J,DeKoter RP
Mon Oct 01 00:00:00 EDT 2012
Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia.
PloS one
Eftychi C,Karagianni N,Alexiou M,Apostolaki M,Kollias G
Tue Jul 31 00:00:00 EDT 2012
JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency.
Nature communications
van Oosten AL,Costa Y,Smith A,Silva JC
Tue May 08 00:00:00 EDT 2012
IL-36R ligands are potent regulators of dendritic and T cells.
Blood
Vigne S,Palmer G,Lamacchia C,Martin P,Talabot-Ayer D,Rodriguez E,Ronchi F,Sallusto F,Dinh H,Sims JE,Gabay C
Thu Nov 24 00:00:00 EST 2011
Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance.
Blood
Kreisel D,Sugimoto S,Zhu J,Nava R,Li W,Okazaki M,Yamamoto S,Ibrahim M,Huang HJ,Toth KA,Ritter JH,Krupnick AS,Miller MJ,Gelman AE
Thu Dec 01 00:00:00 EST 2011
In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors.
Blood
Richie Ehrlich LI,Serwold T,Weissman IL
Thu Mar 03 00:00:00 EST 2011
Activation of the unfolded protein response is associated with impaired granulopoiesis in transgenic mice expressing mutant Elane.
Blood
Nanua S,Murakami M,Xia J,Grenda DS,Woloszynek J,Strand M,Link DC
Thu Mar 31 00:00:00 EDT 2011
Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis.
The Journal of clinical investigation
Kreisel D,Sugimoto S,Tietjens J,Zhu J,Yamamoto S,Krupnick AS,Carmody RJ,Gelman AE
Sat Jan 01 00:00:00 EST 2011
Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.
The Journal of experimental medicine
Heltemes-Harris LM,Willette MJ,Ramsey LB,Qiu YH,Neeley ES,Zhang N,Thomas DA,Koeuth T,Baechler EC,Kornblau SM,Farrar MA
Mon Jun 06 00:00:00 EDT 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
Mon Apr 11 00:00:00 EDT 2011
Sortase-catalyzed transformations that improve the properties of cytokines.
Proceedings of the National Academy of Sciences of the United States of America
Popp MW,Dougan SK,Chuang TY,Spooner E,Ploegh HL
Tue Feb 22 00:00:00 EST 2011
Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice.
Journal of immunology (Baltimore, Md. : 1950)
Maxwell MJ,Duan M,Armes JE,Anderson GP,Tarlinton DM,Hibbs ML
Wed Jun 15 00:00:00 EDT 2011
Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism.
PloS one
Waight JD,Hu Q,Miller A,Liu S,Abrams SI
Mon Mar 26 00:00:00 EDT 2012
R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization.
The Journal of biological chemistry
Shang X,Cancelas JA,Li L,Guo F,Liu W,Johnson JF,Ficker A,Daria D,Geiger H,Ratner N,Zheng Y
Fri Jul 08 00:00:00 EDT 2011
Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development.
PloS one
Yamamoto M,Kato T,Hotta C,Nishiyama A,Kurotaki D,Yoshinari M,Takami M,Ichino M,Nakazawa M,Matsuyama T,Kamijo R,Kitagawa S,Ozato K,Tamura T
Thu Feb 02 00:00:00 EST 2012
Differential Secondary Reconstitution of In Vivo-Selected Human SCID-Repopulating Cells in NOD/SCID versus NOD/SCID/γ chain Mice.
Bone marrow research
Cai S,Wang H,Bailey B,Hartwell JR,Silver JM,Juliar BE,Sinn AL,Baluyut AR,Pollok KE
Thu Nov 10 00:00:00 EST 2011
Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism.
PloS one
Cain DW,Snowden PB,Sempowski GD,Kelsoe G
Wed Oct 05 00:00:00 EDT 2011
Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
Nature
Ji H,Ehrlich LI,Seita J,Murakami P,Doi A,Lindau P,Lee H,Aryee MJ,Irizarry RA,Kim K,Rossi DJ,Inlay MA,Serwold T,Karsunky H,Ho L,Daley GQ,Weissman IL,Feinberg AP
Thu Sep 16 00:00:00 EDT 2010
A reprogrammable mouse strain from gene-targeted embryonic stem cells.
Nature methods
Stadtfeld M,Maherali N,Borkent M,Hochedlinger K
Fri Jan 01 00:00:00 EST 2010
Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.
Blood
Dedhia PH,Keeshan K,Uljon S,Xu L,Vega ME,Shestova O,Zaks-Zilberman M,Romany C,Blacklow SC,Pear WS
Thu Aug 26 00:00:00 EDT 2010
Essential role for focal adhesion kinase in regulating stress hematopoiesis.
Blood
Vemula S,Ramdas B,Hanneman P,Martin J,Beggs HE,Kapur R
Thu Nov 18 00:00:00 EST 2010
ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.
Blood
Vemula S,Shi J,Hanneman P,Wei L,Kapur R
Thu Mar 04 00:00:00 EST 2010
Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein.
PloS one
Jiang D,Schwarz H
Mon Dec 13 00:00:00 EST 2010
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.
Nature
Viale A,De Franco F,Orleth A,Cambiaghi V,Giuliani V,Bossi D,Ronchini C,Ronzoni S,Muradore I,Monestiroli S,Gobbi A,Alcalay M,Minucci S,Pelicci PG
Thu Jan 01 00:00:00 EST 2009
MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.
Cell
Sarrazin S,Mossadegh-Keller N,Fukao T,Aziz A,Mourcin F,Vanhille L,Kelly Modis L,Kastner P,Chan S,Duprez E,Otto C,Sieweke MH
Thu Jul 23 00:00:00 EDT 2009
The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.
Blood
Kimura A,Rieger MA,Simone JM,Chen W,Wickre MC,Zhu BM,Hoppe PS,O'Shea JJ,Schroeder T,Hennighausen L
Thu Nov 19 00:00:00 EST 2009
Gfi1 regulates miR-21 and miR-196b to control myelopoiesis.
Blood
Velu CS,Baktula AM,Grimes HL
Thu May 07 00:00:00 EDT 2009
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.
Blood
Allen JD,Jaffer ZM,Park SJ,Burgin S,Hofmann C,Sells MA,Chen S,Derr-Yellin E,Michels EG,McDaniel A,Bessler WK,Ingram DA,Atkinson SJ,Travers JB,Chernoff J,Clapp DW
Thu Mar 19 00:00:00 EDT 2009
E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors.
Proceedings of the National Academy of Sciences of the United States of America
Semerad CL,Mercer EM,Inlay MA,Weissman IL,Murre C
Tue Feb 10 00:00:00 EST 2009
Thioredoxin-interacting protein regulates hematopoietic stem cell quiescence and mobilization under stress conditions.
Journal of immunology (Baltimore, Md. : 1950)
Jeong M,Piao ZH,Kim MS,Lee SH,Yun S,Sun HN,Yoon SR,Chung JW,Kim TD,Jeon JH,Lee J,Kim HN,Choi JY,Choi I
Sat Aug 15 00:00:00 EDT 2009
Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures.
Journal of neuroinflammation
Lisak RP,Benjamins JA,Bealmear B,Nedelkoska L,Studzinski D,Retland E,Yao B,Land S
Wed Jan 21 00:00:00 EST 2009
A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis.
Blood
Eyles JL,Hickey MJ,Norman MU,Croker BA,Roberts AW,Drake SF,James WG,Metcalf D,Campbell IK,Wicks IP
Mon Dec 15 00:00:00 EST 2008
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.
Proceedings of the National Academy of Sciences of the United States of America
Gan B,Sahin E,Jiang S,Sanchez-Aguilera A,Scott KL,Chin L,Williams DA,Kwiatkowski DJ,DePinho RA
Tue Dec 09 00:00:00 EST 2008
Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages.
Stem cells (Dayton, Ohio)
Schenke-Layland K,Rhodes KE,Angelis E,Butylkova Y,Heydarkhan-Hagvall S,Gekas C,Zhang R,Goldhaber JI,Mikkola HK,Plath K,MacLellan WR
Sun Jun 01 00:00:00 EDT 2008
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.
Blood
Yang L,Wang L,Kalfa TA,Cancelas JA,Shang X,Pushkaran S,Mo J,Williams DA,Zheng Y
Sat Dec 01 00:00:00 EST 2007
TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.
The Journal of clinical investigation
Li J,Sejas DP,Zhang X,Qiu Y,Nattamai KJ,Rani R,Rathbun KR,Geiger H,Williams DA,Bagby GC,Pang Q
Thu Nov 01 00:00:00 EDT 2007
