Product References
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
315-05 was used in In vitro experiments to establish both direct and indirect roles for ILC2 in peri-aortic CaPO4 injury-induced mouse abdominal aortic aneurysms.
Wed Mar 01 00:00:00 EST 2023
Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation.
Small (Weinheim an der Bergstrasse, Germany)
Kwak G,Cheng J,Kim H,Song S,Lee SJ,Yang Y,Jeong JH,Lee JE,Messersmith PB,Kim SH
Fri Apr 01 00:00:00 EDT 2022
Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment.
Oncogene
Fjæstad KY,Rømer AMA,Goitea V,Johansen AZ,Thorseth ML,Carretta M,Engelholm LH,Grøntved L,Junker N,Madsen DH
Tue Feb 01 00:00:00 EST 2022
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques.
Mucosal immunology
Nagatake T,Kishino S,Urano E,Murakami H,Kitamura N,Konishi K,Ohno H,Tiwari P,Morimoto S,Node E,Adachi J,Abe Y,Isoyama J,Sawane K,Honda T,Inoue A,Uwamizu A,Matsuzaka T,Miyamoto Y,Hirata SI,Saika A,Shibata Y,Hosomi K,Matsunaga A,Shimano H,Arita M,Aoki J,Oka M,Matsutani A,Tomonaga T,Kabashima K,Miyachi M,Yasutomi Y,Ogawa J,Kunisawa J
Tue Feb 01 00:00:00 EST 2022
Cerebrospinal fluid of progressive multiple sclerosis patients reduces differentiation and immune functions of oligodendrocyte progenitor cells.
Glia
Zveik O,Fainstein N,Rechtman A,Haham N,Ganz T,Lavon I,Brill L,Vaknin-Dembinsky A
Wed Jun 01 00:00:00 EDT 2022
Physachenolide C induces complete regression of established murine melanoma tumors via apoptosis and cell cycle arrest.
Translational oncology
Adams AC,Macy AM,Kang P,Castro-Ochoa KF,Wijeratne EMK,Xu YM,Liu MX,Charos A,Bosenberg MW,Gunatilaka AAL,Sertil AR,Hastings KT
315-05 was used in Sample Preparation (FC/FACS) to develop treatment for resistant melanoma such as via physachenolide C.
Sat Jan 01 00:00:00 EST 2022
Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4.
iScience
Colombo G,Travelli C,Porta C,Genazzani AA
315-05 was used in Sample Preparation (Western Blotting) to demonstrate that eNAMPT promotes inflammation by favoring both the recruitment of myeloid cells and the induction of an inflammatory transcriptional program.
Fri Apr 15 00:00:00 EDT 2022
CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia.
Nature communications
Allouch A,Voisin L,Zhang Y,Raza SQ,Lecluse Y,Calvo J,Selimoglu-Buet D,de Botton S,Louache F,Pflumio F,Solary E,Perfettini JL
315-05 was used in In vivo experiments to reveal p21 as a trigger of phagocytosis-guided pro-inflammatory TAM reprogramming and highlight the potential for p21TD-Mo-based cellular therapy as a cancer immunotherapy.
Tue Nov 08 00:00:00 EST 2022
Sodium Tanshinone IIA Sulfonate as a Potent IDO1/TDO2 Dual Inhibitor Enhances Anti-PD1 Therapy for Colorectal Cancer in Mice.
Frontiers in pharmacology
Zhang R,Wang Y,Liu D,Luo Q,Du P,Zhang H,Wu W
315-05 was used in Sample Preparation (FC/FACS) to determine signaling processes in immune checkpoint blockade in colorectal cancer.
Sat Jul 16 00:00:00 EDT 2022
TNF-α/IFN-γ synergy amplifies senescence-associated inflammation and SARS-CoV-2 receptor expression via hyper-activated JAK/STAT1.
Aging cell
Kandhaya-Pillai R,Yang X,Tchkonia T,Martin GM,Kirkland JL,Oshima J
315-05 was used in In vitro experiments to find exposure of human umbilical vein endothelial cells (HUVECs) to the inflammatory cytokines, TNF-α + IFN-γ or a cocktail of TNF-α + IFN-γ + IL-6, increased expression of ACE2/DPP4, accentuated the pro-inflammatory senescence-associated secretory phenotype (SASP), and decreased cellular proliferative capacity, consistent with progression towards a cellular senescence-like state.
Wed Jun 01 00:00:00 EDT 2022
Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells of a Healthy Donor on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata: Targeting Dysregulated T Cells and the Acquisition of Immunotolerance.
International journal of molecular sciences
Kim JE,Lee YJ,Lee KJ,Park SH,Kang H
315-05 was used in In vitro experiments to suggest that allogenic hMSC treatments have therapeutic potential to induce immune tolerance and anti-inflammatory effects in severe AA patients.
Sun Oct 30 00:00:00 EDT 2022
Evaluation of Glutaminolysis in T Cells.
Current protocols
Tajima M,Strober W
315-05 was used in Cell Culture to provide one element of such tracking by describing protocols for the assessment of the contribution of glutaminolysis to overall ATP production within different T cell subsets.
Thu Sep 01 00:00:00 EDT 2022
Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages.
Frontiers in pharmacology
Huang B,Wang Q,Jiang L,Lu S,Li C,Xu C,Wang C,Zhang E,Zhang X
315-05 was used in Cell Culture to study which PKM2 conformation is inhibited by the Shikonin inhibitor and whether the inhibition mediates the pharmacological effect of Shikonin by investigating the efficacy of Shikonin on dextran sulfate sodium-induced mice colitis and examining the states of PKM2 aggregation.
Wed Sep 07 00:00:00 EDT 2022
Special Focus on the Cellular Anti-Inflammatory Effects of Several Micro-Immunotherapy Formulations: Considerations Regarding Intestinal-, Immune-Axis-Related- and Neuronal-Inflammation Contexts.
Journal of inflammation research
Jacques C,Floris I
315-05 was used in Cell Culture to reveal that u-MIM-1 and u-MIM-2 both induced a slight decrease in the levels of IL-1β and TNF-α transcripts.
Thu Dec 22 00:00:00 EST 2022
Inactivation of AUF1 in Myeloid Cells Protects From Allergic Airway and Tumor Infiltration and Impairs the Adenosine-Induced Polarization of Pro-Angiogenic Macrophages.
Frontiers in immunology
Gargani S,Lourou N,Arapatzi C,Tzanos D,Saridaki M,Dushku E,Chatzimike M,Sidiropoulos ND,Andreadou M,Ntafis V,Hatzis P,Kostourou V,Kontoyiannis DL
315-05 was used in Cell Culture to study the requirement of AUF1s in variable contexts of innate immune reactivity by restricting a debilitating AUF1 mutation to the mouse myeloid lineage and perform disease-oriented phenotypic analyses.
Fri Apr 08 00:00:00 EDT 2022
Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kα/β/δ treatment.
Nature communications
Qi Z,Xu Z,Zhang L,Zou Y,Li J,Yan W,Li C,Liu N,Wu H
315-05 was used in In vitro experiments to suggest that intermittent PI3K inhibition can alleviate Pten-null cancer cell-intrinsic immunosuppressive activity and turn cold" tumors into T cell-inflamed ones
Mon Jan 10 00:00:00 EST 2022
An integrated toolbox to profile macrophage immunometabolism.
Cell reports methods
Verberk SGS,de Goede KE,Gorki FS,van Dierendonck XAMH,Argüello RJ,Van den Bossche J
315-05 was used in Cell Culture to propose an application of SCENITH technology for ex vivo metabolic profiling.
Mon Apr 25 00:00:00 EDT 2022
The HIFα-Stabilizing Drug Roxadustat Increases the Number of Renal Epo-Producing Sca-1+ Cells.
Cells
Jatho A,Zieseniss A,Brechtel-Curth K,Guo J,Böker KO,Salinas G,Wenger RH,Katschinski DM
315-05 was used in Cell Culture to characterize the abundance of mesenchymal stem cell (MSC)-like cells after roxadustat treatment of mice.
Mon Feb 21 00:00:00 EST 2022
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.
Nature
Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA
315-05 was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.
Thu Apr 01 00:00:00 EDT 2021
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.
Nature
Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA
315-05 was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.
Thu Apr 01 00:00:00 EDT 2021
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Cell
Gangoso E,Southgate B,Bradley L,Rus S,Galvez-Cancino F,McGivern N,Güç E,Kapourani CA,Byron A,Ferguson KM,Alfazema N,Morrison G,Grant V,Blin C,Sou I,Marques-Torrejon MA,Conde L,Parrinello S,Herrero J,Beck S,Brandner S,Brennan PM,Bertone P,Pollard JW,Quezada SA,Sproul D,Frame MC,Serrels A,Pollard SM
Thu Apr 29 00:00:00 EDT 2021
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.
Cell
Lu SX,De Neef E,Thomas JD,Sabio E,Rousseau B,Gigoux M,Knorr DA,Greenbaum B,Elhanati Y,Hogg SJ,Chow A,Ghosh A,Xie A,Zamarin D,Cui D,Erickson C,Singer M,Cho H,Wang E,Lu B,Durham BH,Shah H,Chowell D,Gabel AM,Shen Y,Liu J,Jin J,Rhodes MC,Taylor RE,Molina H,Wolchok JD,Merghoub T,Diaz LA,Abdel-Wahab O,Bradley RK
315-05 was used in Cell Culture to investigate RNA splicing effects in antigen production in cancer.
Thu Jul 22 00:00:00 EDT 2021
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.
Cell
Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD
315-05 was used in Enzyme-linked immunosorbent assay to show that only the combination of TNF-α and IFN-γ induced inflammatory cell death characterized by inflammatory cell death, PANoptosis while multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection.
Thu Jan 07 00:00:00 EST 2021
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.
Cell
Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD
315-05 was used in Enzyme-linked immunosorbent assay to show that only the combination of TNF-α and IFN-γ induced inflammatory cell death characterized by inflammatory cell death, PANoptosis while multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection.
Thu Jan 07 00:00:00 EST 2021
The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake.
Immunity
de Mingo Pulido Á,Hänggi K,Celias DP,Gardner A,Li J,Batista-Bittencourt B,Mohamed E,Trillo-Tinoco J,Osunmakinde O,Peña R,Onimus A,Kaisho T,Kaufmann J,McEachern K,Soliman H,Luca VC,Rodriguez PC,Yu X,Ruffell B
Tue Jun 08 00:00:00 EDT 2021
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer.
Cancer cell
Freed-Pastor WA,Lambert LJ,Ely ZA,Pattada NB,Bhutkar A,Eng G,Mercer KL,Garcia AP,Lin L,Rideout WM,Hwang WL,Schenkel JM,Jaeger AM,Bronson RT,Westcott PMK,Hether TD,Divakar P,Reeves JW,Deshpande V,Delorey T,Phillips D,Yilmaz OH,Regev A,Jacks T
Mon Oct 11 00:00:00 EDT 2021
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.
Cell metabolism
Willenborg S,Sanin DE,Jais A,Ding X,Ulas T,Nüchel J,Popović M,MacVicar T,Langer T,Schultze JL,Gerbaulet A,Roers A,Pearce EJ,Brüning JC,Trifunovic A,Eming SA
Tue Dec 07 00:00:00 EST 2021
Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells.
Cellular & molecular immunology
Zhang J,Huang J,Gu Y,Xue M,Qian F,Wang B,Yang W,Yu H,Wang Q,Guo X,Ding X,Wang J,Jin M,Zhang Y
Tue Jun 01 00:00:00 EDT 2021
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.
Molecular cell
Durgan J,Lystad AH,Sloan K,Carlsson SR,Wilson MI,Marcassa E,Ulferts R,Webster J,Lopez-Clavijo AF,Wakelam MJ,Beale R,Simonsen A,Oxley D,Florey O
Thu May 06 00:00:00 EDT 2021
Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation.
The Journal of experimental medicine
Arasa J,Collado-Diaz V,Kritikos I,Medina-Sanchez JD,Friess MC,Sigmund EC,Schineis P,Hunter MC,Tacconi C,Paterson N,Nagasawa T,Kiefer F,Makinen T,Detmar M,Moser M,Lämmermann T,Halin C
Mon Jul 05 00:00:00 EDT 2021
Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.
The Journal of experimental medicine
Sasai M,Ma JS,Okamoto M,Nishino K,Nagaoka H,Takashima E,Pradipta A,Lee Y,Kosako H,Suh PG,Yamamoto M
Mon Jul 05 00:00:00 EDT 2021
Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation.
The Journal of experimental medicine
Vijay R,Guthmiller JJ,Sturtz AJ,Crooks S,Johnson JT,Li L,Lan LY,Pope RL,Chen Y,Rogers KJ,Dutta N,Toombs JE,Wilson ME,Wilson PC,Maury W,Brekken RA,Butler NS
Mon Jun 07 00:00:00 EDT 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
315-05 was used in In vitro experiments to better understand the roles of intestinal epithelial cells.
Mon Apr 05 00:00:00 EDT 2021
CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes.
The Journal of experimental medicine
Kosaka A,Ishibashi K,Nagato T,Kitamura H,Fujiwara Y,Yasuda S,Nagata M,Harabuchi S,Hayashi R,Yajima Y,Ohara K,Kumai T,Aoki N,Komohara Y,Oikawa K,Harabuchi Y,Kitada M,Kobayashi H,Ohkuri T
Mon Nov 01 00:00:00 EDT 2021
RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling.
Proceedings of the National Academy of Sciences of the United States of America
Chen KW,Demarco B,Ramos S,Heilig R,Goris M,Grayczyk JP,Assenmacher CA,Radaelli E,Joannas LD,Henao-Mejia J,Tacchini-Cottier F,Brodsky IE,Broz P
Tue Jul 13 00:00:00 EDT 2021
Functional genomics and metabolomics advance the ethnobotany of the Samoan traditional medicine "matalafi".
Proceedings of the National Academy of Sciences of the United States of America
Molimau-Samasoni S,Woolner VH,Foliga ST,Robichon K,Patel V,Andreassend SK,Sheridan JP,Te Kawa T,Gresham D,Miller D,Sinclair DJ,La Flamme AC,Melnik AV,Aron A,Dorrestein PC,Atkinson PH,Keyzers RA,Munkacsi AB
Tue Nov 09 00:00:00 EST 2021
SLC15A4 mediates M1-prone metabolic shifts in macrophages and guards immune cells from metabolic stress.
Proceedings of the National Academy of Sciences of the United States of America
Kobayashi T,Nguyen-Tien D,Sorimachi Y,Sugiura Y,Suzuki T,Karyu H,Shimabukuro-Demoto S,Uemura T,Okamura T,Taguchi T,Ueki K,Kato N,Goda N,Dohmae N,Takubo K,Suematsu M,Toyama-Sorimachi N
Tue Aug 17 00:00:00 EDT 2021
Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
Proceedings of the National Academy of Sciences of the United States of America
Ho WW,Gomes-Santos IL,Aoki S,Datta M,Kawaguchi K,Talele NP,Roberge S,Ren J,Liu H,Chen IX,Andersson P,Chatterjee S,Kumar AS,Amoozgar Z,Zhang Q,Huang P,Ng MR,Chauhan VP,Xu L,Duda DG,Clark JW,Pittet MJ,Fukumura D,Jain RK
Tue Nov 09 00:00:00 EST 2021
Opposing functions of β-arrestin 1 and 2 in Parkinson's disease via microglia inflammation and Nprl3.
Cell death and differentiation
Fang Y,Jiang Q,Li S,Zhu H,Xu R,Song N,Ding X,Liu J,Chen M,Song M,Ding J,Lu M,Wu G,Hu G
Tue Jun 01 00:00:00 EDT 2021
An asymmetric junctional mechanoresponse coordinates mitotic rounding with epithelial integrity.
The Journal of cell biology
Monster JL,Donker L,Vliem MJ,Win Z,Matthews HK,Cheah JS,Yamada S,de Rooij J,Baum B,Gloerich M
Mon May 03 00:00:00 EDT 2021
M1 Bone Marrow-Derived Macrophage-Derived Extracellular Vesicles Inhibit Angiogenesis and Myocardial Regeneration Following Myocardial Infarction via the MALAT1/MicroRNA-25-3p/CDC42 Axis.
Oxidative medicine and cellular longevity
Chen B,Luo L,Wei X,Gong D,Li Z,Li S,Tang W,Jin L
Thu Feb 17 00:00:00 EST 2022
Mesenchymal stromal cells expressing a dominant-negative high mobility group A1 transgene exhibit improved function during sepsis.
Journal of leukocyte biology
Kwon MY,Ghanta S,Ng J,Castano AP,Han J,Ith B,Lederer JA,El-Chemaly S,Chung SW,Liu X,Perrella MA
Fri Oct 01 00:00:00 EDT 2021
Amino acids and mechanistic target of rapamycin regulate the fate of live engulfed cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Kim SE,Zhang J,Jiang E,Overholtzer M
Fri Oct 01 00:00:00 EDT 2021
A Monocyte-Orchestrated IFN-I-to-IL-4 Cytokine Axis Instigates Protumoral Macrophages and Thwarts Poly(I:C) Therapy.
Journal of immunology (Baltimore, Md. : 1950)
Guo P,Yang L,Zhang M,Zhang Y,Tong Y,Cao Y,Liu J
Thu Jul 15 00:00:00 EDT 2021
Amelioration of Graft-versus-Host Disease by Exopolysaccharide from a Commensal Bacterium.
Journal of immunology (Baltimore, Md. : 1950)
Kalinina O,Talley S,Zamora-Pineda J,Paik W,Campbell EM,Knight KL
Sat May 01 00:00:00 EDT 2021
Histone deacetylase 9 deficiency exaggerates uterine M2 macrophage polarization.
Journal of cellular and molecular medicine
Liu Y,Du M,Lin HY
Sun Aug 01 00:00:00 EDT 2021
VEGF Contributes to Mesenchymal Stem Cell-Mediated Reversion of Nor1-Dependent Hypertrophy in iPS Cell-Derived Cardiomyocytes.
Stem cells international
Philipp D,Holthaus M,Basoah V,Pfannkuche K,Suhr L,Wahlers T,Paunel-Görgülü A
Sun May 02 00:00:00 EDT 2021
Release of HMGB1 in Podocytes Exacerbates Lipopolysaccharide-Induced Acute Kidney Injury.
Mediators of inflammation
Gao Z,Lu L,Chen X
Mon Feb 28 00:00:00 EST 2022
Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction.
Journal of immunology research
Tan J,Dai A,Pan L,Zhang L,Wang Z,Ke T,Sun W,Wu Y,Ding PH,Chen L
Mon Jan 10 00:00:00 EST 2022
Tacrolimus Protects Podocytes from Apoptosis via Downregulation of TRPC6 in Diabetic Nephropathy.
Journal of diabetes research
Ma R,Wang Y,Xu Y,Wang R,Wang X,Yu N,Li M,Zhou Y
Fri Dec 10 00:00:00 EST 2021
Lactate and IL6 define separable paths of inflammatory metabolic adaptation.
Science advances
Dichtl S,Lindenthal L,Zeitler L,Behnke K,Schlösser D,Strobl B,Scheller J,El Kasmi KC,Murray PJ
315-05 was used in Cell Culture to test the interrelationships between histone lactylation (Kla) and tissue reparative gene expression.
Tue Jun 01 00:00:00 EDT 2021
Interleukin-6 receptor alpha and CD27 discriminate intratumoral T helper 17 subpopulations with distinct functional properties in a mouse lung cancer model.
Immunity, inflammation and disease
Liu C,Xiong F,Wang L,Chen K,Wu P,Hua L,Zhang Z
Wed Dec 01 00:00:00 EST 2021
Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF.
Cell death & disease
Buffolo F,Petrosino V,Albini M,Moschetta M,Carlini F,Floss T,Kerlero de Rosbo N,Cesca F,Rocchi A,Uccelli A,Benfenati F
Mon Feb 15 00:00:00 EST 2021
Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model.
Scientific reports
Baloche V,Rivière J,Tran TBT,Gelin A,Bawa O,Signolle N,Diop MBK,Dessen P,Beq S,David M,Busson P
Thu Mar 04 00:00:00 EST 2021
Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis.
iScience
Chatterjee S,Yabaji SM,Rukhlenko OS,Bhattacharya B,Waligurski E,Vallavoju N,Ray S,Kholodenko BN,Brown LE,Beeler AB,Ivanov AR,Kobzik L,Porco JA,Kramnik I
Fri Aug 20 00:00:00 EDT 2021
Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes.
Nature communications
Tan JMJ,Garner ME,Regeimbal JM,Greene CJ,Márquez JDR,Ammendolia DA,McCluggage ARR,Li T,Wu KJ,Cemma M,Ostrowski PP,Raught B,Diamond MS,Grinstein S,Yates RM,Higgins DE,Brumell JH
Tue Aug 17 00:00:00 EDT 2021
Reactive Species from Two-Signal Activated Macrophages Interfere with Their Oxygen Consumption Measurements.
Antioxidants (Basel, Switzerland)
Christopoulos PF,Grigalavicius M,Corthay A,Berg K,Theodossiou TA
315-05 was used in Cell Culture to investigate mitochondrial oxygen consumption in macrophage activation.
Tue Jul 20 00:00:00 EDT 2021
Exosome-mediated delivery of inflammation-responsive Il-10 mRNA for controlled atherosclerosis treatment.
Theranostics
Bu T,Li Z,Hou Y,Sun W,Zhang R,Zhao L,Wei M,Yang G,Yuan L
315-05 was used in Cell Culture to investigate inflammation control for the treatment of inflammatory disease.
Mon Feb 07 00:00:00 EST 2022
Central Nervous System Barriers Impact Distribution and Expression of iNOS and Arginase-1 in Infiltrating Macrophages During Neuroinflammation.
Frontiers in immunology
Ivan DC,Walthert S,Locatelli G
315-05 was used in Cell Culture to indicate differential distribution of pro- and anti-inflammatory MoCs at CNS borders and highlight how the interaction of MoCs with CNS barriers can significantly affect the functional activation of these CNS-invading MoCs during autoimmune inflammation.
Mon Oct 25 00:00:00 EDT 2021
Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics.
iScience
Nascimento Da Conceicao V,Sun Y,Ramachandran K,Chauhan A,Raveendran A,Venkatesan M,DeKumar B,Maity S,Vishnu N,Kotsakis GA,Worley PF,Gill DL,Mishra BB,Madesh M,Singh BB
Fri Nov 19 00:00:00 EST 2021
Characterization and Functional Analysis of Tumor-Derived Microparticles.
Current protocols
Ma J,Tang K,Zhang H,Wei K,Huang B
Tue Jun 01 00:00:00 EDT 2021
Targeting TREM2 on tumor-associated macrophages enhances immunotherapy.
Cell reports
Binnewies M,Pollack JL,Rudolph J,Dash S,Abushawish M,Lee T,Jahchan NS,Canaday P,Lu E,Norng M,Mankikar S,Liu VM,Du X,Chen A,Mehta R,Palmer R,Juric V,Liang L,Baker KP,Reyno L,Krummel MF,Streuli M,Sriram V
Tue Oct 19 00:00:00 EDT 2021
Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages.
Nature communications
Gupte R,Nandu T,Kraus WL
Thu Jun 24 00:00:00 EDT 2021
A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state.
Cell reports
Fremder M,Kim SW,Khamaysi A,Shimshilashvili L,Eini-Rider H,Park IS,Hadad U,Cheon JH,Ohana E
Tue Aug 10 00:00:00 EDT 2021
Comparing the protective effects of resveratrol, curcumin and sulforaphane against LPS/IFN-γ-mediated inflammation in doxorubicin-treated macrophages.
Scientific reports
Saleh HA,Ramdan E,Elmazar MM,Azzazy HME,Abdelnaser A
Tue Jan 12 00:00:00 EST 2021
Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses.
Cell reports
Yu K,Hammerschmidt SI,Permanyer M,Galla M,Rothe M,Zheng X,Werth K,Martens R,Lueder Y,Janssen A,Friedrichsen M,Bernhardt G,Förster R
Tue Jun 22 00:00:00 EDT 2021
Entosis is induced by ultraviolet radiation.
iScience
Chen R,Ram A,Albeck JG,Overholtzer M
Fri Aug 20 00:00:00 EDT 2021
Talabostat Alleviates Obesity and Associated Metabolic Dysfunction via Suppression of Macrophage-Driven Adipose Inflammation.
Obesity (Silver Spring, Md.)
Wu Y,Shi T,Wang J,He R
315-05 was used in In vitro experiments to demonstrate that TB at a low dose could increase energy expenditure and control ATM-mediated adipose inflammation in obese mice, thereby alleviating obesity and its associated metabolic dysfunction.
Mon Feb 01 00:00:00 EST 2021
4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen.
eLife
Tabakh H,McFarland AP,Thomason MK,Pollock AJ,Glover RC,Zaver SA,Woodward JJ
315-05 was used in Sample Preparation to demonstrate that 4-HNE is a previously unappreciated component of ROS-mediated toxicity encountered by bacteria within eukaryotic hosts.
Thu May 06 00:00:00 EDT 2021
TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread.
Nature communications
Oyler-Yaniv J,Oyler-Yaniv A,Maltz E,Wollman R
Thu May 20 00:00:00 EDT 2021
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.
Nature communications
Clement CC,D'Alessandro A,Thangaswamy S,Chalmers S,Furtado R,Spada S,Mondanelli G,Ianni F,Gehrke S,Gargaro M,Manni G,Cara LCL,Runge P,Tsai WL,Karaman S,Arasa J,Fernandez-Rodriguez R,Beck A,Macchiarulo A,Gadina M,Halin C,Fallarino F,Skobe M,Veldhoen M,Moretti S,Formenti S,Demaria S,Soni RK,Galarini R,Sardella R,Lauvau G,Putterman C,Alitalo K,Grohmann U,Santambrogio L
Wed Jul 21 00:00:00 EDT 2021
Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis.
Nature communications
Wang X,Hu LP,Qin WT,Yang Q,Chen DY,Li Q,Zhou KX,Huang PQ,Xu CJ,Li J,Yao LL,Wang YH,Tian GA,Yang JY,Yang MW,Liu DJ,Sun YW,Jiang SH,Zhang XL,Zhang ZG
Fri Jan 08 00:00:00 EST 2021
Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription.
Cell reports
Sun L,Zhao X,Liu X,Zhong B,Tang H,Jin W,Clevers H,Wang H,Wang X,Dong C
Tue Jun 01 00:00:00 EDT 2021
Loss of miR-24-3p promotes epithelial cell apoptosis and impairs the recovery from intestinal inflammation.
Cell death & disease
Soroosh A,Fang K,Hoffman JM,Law IKM,Videlock E,Lokhandwala ZA,Zhao JJ,Hamidi S,Padua DM,Frey MR,Pothoulakis C,Rankin CR
Sat Dec 18 00:00:00 EST 2021
Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages.
Cell discovery
Lv J,Wang Z,Qu Y,Zhu H,Zhu Q,Tong W,Bao L,Lv Q,Cong J,Li D,Deng W,Yu P,Song J,Tong WM,Liu J,Liu Y,Qin C,Huang B
Tue Apr 13 00:00:00 EDT 2021
Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy.
Nature communications
Jiang CT,Chen KG,Liu A,Huang H,Fan YN,Zhao DK,Ye QN,Zhang HB,Xu CF,Shen S,Xiong MH,Du JZ,Yang XZ,Wang J
Mon Mar 01 00:00:00 EST 2021
Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells.
eLife
Kiritsy MC,McCann K,Mott D,Holland SM,Behar SM,Sassetti CM,Olive AJ
315-05 was used in In vitro experiments to study the metabolic dependencies of critical signals such as interferon gamma (IFNγ) for allowing antigen-presenting cells (APCs) to convey a wide array of functionally distinct signals to T cells. To demonstrate that IFNγ response requires mitochondrial respiration, and APCs are unable to activate T cells upon genetic or chemical inhibition of complex I.
Tue Nov 02 00:00:00 EDT 2021
Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity.
Cell death & disease
Hu RD,Zhang W,Li L,Zuo ZQ,Ma M,Ma JF,Yin TT,Gao CY,Yang SH,Zhao ZB,Li ZJ,Qiao GB,Lian ZX,Qu K
Fri Oct 29 00:00:00 EDT 2021
A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma.
Cell reports methods
Fitzgerald B,Connolly KA,Cui C,Fagerberg E,Mariuzza DL,Hornick NI,Foster GG,William I,Cheung JF,Joshi NS
Mon Sep 27 00:00:00 EDT 2021
Tailored co-localization analysis of intracellular microbes and punctum-distributed phagosome-lysosome pathway proteins using ImageJ plugin EzColocalization.
Scientific reports
Wu K,Yan B,Lowrie DB,Li T,Fan XY
Wed Jan 13 00:00:00 EST 2021
Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells.
Nature communications
Muñoz-Rojas AR,Kelsey I,Pappalardo JL,Chen M,Miller-Jensen K
Tue Jan 12 00:00:00 EST 2021
Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity.
Nature communications
Weigelin B,den Boer AT,Wagena E,Broen K,Dolstra H,de Boer RJ,Figdor CG,Textor J,Friedl P
Wed Sep 01 00:00:00 EDT 2021
Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.
Nature communications
Jin H,Liu K,Tang J,Huang X,Wang H,Zhang Q,Zhu H,Li Y,Pu W,Zhao H,He L,Li Y,Zhang S,Zhang Z,Zhao Y,Qin Y,Pflanz S,Kasmi KEI,Zhang W,Liu Z,Ginhoux F,Ji Y,He B,Wang L,Zhou B
Mon May 17 00:00:00 EDT 2021
Shigella OspC3 suppresses murine cytosolic LPS sensing.
iScience
Oh C,Verma A,Hafeez M,Hogland B,Aachoui Y
315-05 was used in In vitro experiments to reveal that OspC3 suppresses cytosolic LPS detection in a broad array of mammals.
Fri Aug 20 00:00:00 EDT 2021
Novel standardized method for extracellular flux analysis of oxidative and glycolytic metabolism in peripheral blood mononuclear cells.
Scientific reports
Janssen JJE,Lagerwaard B,Bunschoten A,Savelkoul HFJ,van Neerven RJJ,Keijer J,de Boer VCJ
Mon Jan 18 00:00:00 EST 2021
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming.
Nature communications
Yin H,Zhang X,Yang P,Zhang X,Peng Y,Li D,Yu Y,Wu Y,Wang Y,Zhang J,Ding X,Wang X,Yang A,Zhang R
Tue Mar 02 00:00:00 EST 2021
Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools.
The Journal of biological chemistry
Morgan PK,Huynh K,Pernes G,Miotto PM,Mellett NA,Giles C,Meikle PJ,Murphy AJ,Lancaster GI
Wed Dec 01 00:00:00 EST 2021
Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.
Frontiers in immunology
Ji WH,Li DD,Wei DP,Gu AQ,Yang Y,Peng JP
315-05 was used in Cell Culture to investigate whether Cytochrome P450 26A1 (CYP26A1) regulates the polarization of uterine macrophages in early pregnancy.
Thu Feb 10 00:00:00 EST 2022
ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.
Cell reports
Karki R,Sundaram B,Sharma BR,Lee S,Malireddi RKS,Nguyen LN,Christgen S,Zheng M,Wang Y,Samir P,Neale G,Vogel P,Kanneganti TD
Tue Oct 19 00:00:00 EDT 2021
Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer.
NPJ breast cancer
Draganov D,Han Z,Rana A,Bennett N,Irvine DJ,Lee PP
Tue Mar 02 00:00:00 EST 2021
Integrating CD4+ T cell help for therapeutic cancer vaccination in a preclinical head and neck cancer model.
Oncoimmunology
Shibata H,Xu N,Saito S,Zhou L,Ozgenc I,Webb J,Fu C,Zolkind P,Egloff AM,Uppaluri R
315-05 was used in In vitro experiments to evaluate therapeutic vaccination in the mouse oral cancer (MOC) 22 model.
Fri Oct 15 00:00:00 EDT 2021
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Cell
Pasciuto E,Burton OT,Roca CP,Lagou V,Rajan WD,Theys T,Mancuso R,Tito RY,Kouser L,Callaerts-Vegh Z,de la Fuente AG,Prezzemolo T,Mascali LG,Brajic A,Whyte CE,Yshii L,Martinez-Muriana A,Naughton M,Young A,Moudra A,Lemaitre P,Poovathingal S,Raes J,De Strooper B,Fitzgerald DC,Dooley J,Liston A
Thu Aug 06 00:00:00 EDT 2020
FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.
Cell
Cader MZ,de Almeida Rodrigues RP,West JA,Sewell GW,Md-Ibrahim MN,Reikine S,Sirago G,Unger LW,Iglesias-Romero AB,Ramshorn K,Haag LM,Saveljeva S,Ebel JF,Rosenstiel P,Kaneider NC,Lee JC,Lawley TD,Bradley A,Dougan G,Modis Y,Griffin JL,Kaser A
Thu Jan 23 00:00:00 EST 2020
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
Cell
Ziegler CGK,Allon SJ,Nyquist SK,Mbano IM,Miao VN,Tzouanas CN,Cao Y,Yousif AS,Bals J,Hauser BM,Feldman J,Muus C,Wadsworth MH,Kazer SW,Hughes TK,Doran B,Gatter GJ,Vukovic M,Taliaferro F,Mead BE,Guo Z,Wang JP,Gras D,Plaisant M,Ansari M,Angelidis I,Adler H,Sucre JMS,Taylor CJ,Lin B,Waghray A,Mitsialis V,Dwyer DF,Buchheit KM,Boyce JA,Barrett NA,Laidlaw TM,Carroll SL,Colonna L,Tkachev V,Peterson CW,Yu A,Zheng HB,Gideon HP,Winchell CG,Lin PL,Bingle CD,Snapper SB,Kropski JA,Theis FJ,Schiller HB,Zaragosi LE,Barbry P,Leslie A,Kiem HP,Flynn JL,Fortune SM,Berger B,Finberg RW,Kean LS,Garber M,Schmidt AG,Lingwood D,Shalek AK,Ordovas-Montanes J
Thu May 28 00:00:00 EDT 2020
Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19.
Cell research
Liu Y,Lv J,Liu J,Li M,Xie J,Lv Q,Deng W,Zhou N,Zhou Y,Song J,Wang P,Qin C,Tong WM,Huang B
Tue Dec 01 00:00:00 EST 2020
Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics.
Immunity
Zenke S,Palm MM,Braun J,Gavrilov A,Meiser P,Böttcher JP,Beyersdorf N,Ehl S,Gerard A,Lämmermann T,Schumacher TN,Beltman JB,Rohr JC
Tue Feb 18 00:00:00 EST 2020
The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation.
Immunity
Chang D,Xing Q,Su Y,Zhao X,Xu W,Wang X,Dong C
Tue Sep 15 00:00:00 EDT 2020
Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma.
Immunity
Effern M,Glodde N,Braun M,Liebing J,Boll HN,Yong M,Bawden E,Hinze D,van den Boorn-Konijnenberg D,Daoud M,Aymans P,Landsberg J,Smyth MJ,Flatz L,Tüting T,Bald T,Gebhardt T,Hölzel M
Tue Sep 15 00:00:00 EDT 2020
High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity.
Immunity
Kim S,Bagadia P,Anderson DA,Liu TT,Huang X,Theisen DJ,O'Connor KW,Ohara RA,Iwata A,Murphy TL,Murphy KM
Tue Oct 13 00:00:00 EDT 2020
Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome.
Cell metabolism
Hsieh WY,Zhou QD,York AG,Williams KJ,Scumpia PO,Kronenberger EB,Hoi XP,Su B,Chi X,Bui VL,Khialeeva E,Kaplan A,Son YM,Divakaruni AS,Sun J,Smale ST,Flavell RA,Bensinger SJ
315-05 was used in Sample Preparation to investigate differences in pro-inflammatory on macrophage lipidome.
Tue Jul 07 00:00:00 EDT 2020
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins.
Nature immunology
Zhou QD,Chi X,Lee MS,Hsieh WY,Mkrtchyan JJ,Feng AC,He C,York AG,Bui VL,Kronenberger EB,Ferrari A,Xiao X,Daly AE,Tarling EJ,Damoiseaux R,Scumpia PO,Smale ST,Williams KJ,Tontonoz P,Bensinger SJ
315-05 was used in Cell Culture to investigate how pathogens escape cholesterol-dependent cytolysins during infection.
Wed Jul 01 00:00:00 EDT 2020
Aging-induced IL27Ra signaling impairs hematopoietic stem cells.
Blood
He H,Xu P,Zhang X,Liao M,Dong Q,Cong T,Tang B,Yang X,Ye M,Chang Y,Liu W,Wang X,Ju Z,Wang J
Thu Jul 09 00:00:00 EDT 2020
JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.
Blood
Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE
Thu Aug 06 00:00:00 EDT 2020
IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells.
The Journal of experimental medicine
Yang Z,Wu CM,Targ S,Allen CDC
Mon May 04 00:00:00 EDT 2020
The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses.
The Journal of experimental medicine
Arnold IC,Artola-Boran M,Gurtner A,Bertram K,Bauer M,Frangez Z,Becher B,Kopf M,Yousefi S,Simon HU,Tzankov A,Müller A
Mon Dec 07 00:00:00 EST 2020
Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain.
The Journal of experimental medicine
Bogie JFJ,Grajchen E,Wouters E,Corrales AG,Dierckx T,Vanherle S,Mailleux J,Gervois P,Wolfs E,Dehairs J,Van Broeckhoven J,Bowman AP,Lambrichts I,Gustafsson JÅ,Remaley AT,Mulder M,Swinnen JV,Haidar M,Ellis SR,Ntambi JM,Zelcer N,Hendriks JJA
Mon May 04 00:00:00 EDT 2020
Additive Therapeutic Effects of Mesenchymal Stem Cells and IL-37 for Systemic Lupus Erythematosus.
Journal of the American Society of Nephrology : JASN
Xu J,Chen J,Li W,Lian W,Huang J,Lai B,Li L,Huang Z
315-05 was used in In vitro experiments to investigate the effect of overexpressing IL-37 on the therapeutic effects of mesenchymal stem cells for Systemic Lupus Erythematosus treatment.
Wed Jan 01 00:00:00 EST 2020
FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer.
EMBO molecular medicine
Zaghdoudi S,Decaup E,Belhabib I,Samain R,Cassant-Sourdy S,Rochotte J,Brunel A,Schlaepfer D,Cros J,Neuzillet C,Strehaiano M,Alard A,Tomasini R,Rajeeve V,Perraud A,Mathonnet M,Pearce OM,Martineau Y,Pyronnet S,Bousquet C,Jean C
Fri Nov 06 00:00:00 EST 2020
MNK2 governs the macrophage antiinflammatory phenotype.
Proceedings of the National Academy of Sciences of the United States of America
Bartish M,Tong D,Pan Y,Wallerius M,Liu H,Ristau J,de Souza Ferreira S,Wallmann T,van Hoef V,Masvidal L,Kerzel T,Joly AL,Goncalves C,Preston SEJ,Ebrahimian T,Seitz C,Bergh J,Pietras K,Lehoux S,Naldini L,Andersson J,Squadrito ML,Del Rincón SV,Larsson O,Rolny C
Tue Nov 03 00:00:00 EST 2020
Aging and sex: Impact on microglia phagocytosis.
Aging cell
Yanguas-Casás N,Crespo-Castrillo A,Arevalo MA,Garcia-Segura LM
Sat Aug 01 00:00:00 EDT 2020
Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells.
Science signaling
Gómez V,Eykyn TR,Mustapha R,Flores-Borja F,Male V,Barber PR,Patsialou A,Green R,Panagaki F,Li CW,Fruhwirth GO,Ros S,Brindle KM,Ng T
Tue Oct 06 00:00:00 EDT 2020
A transcriptional toolbox for exploring peripheral neuroimmune interactions.
Pain
Liang Z,Hore Z,Harley P,Uchenna Stanley F,Michrowska A,Dahiya M,La Russa F,Jager SE,Villa-Hernandez S,Denk F
315-05 was used in Cell Culture to investigate communication between immune cells and peripheral neurones in pain.
Tue Sep 01 00:00:00 EDT 2020
Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease.
Stem cells translational medicine
Losurdo M,Pedrazzoli M,D'Agostino C,Elia CA,Massenzio F,Lonati E,Mauri M,Rizzi L,Molteni L,Bresciani E,Dander E,D'Amico G,Bulbarelli A,Torsello A,Matteoli M,Buffelli M,Coco S
Tue Sep 01 00:00:00 EDT 2020
Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease.
Stem cells translational medicine
Losurdo M,Pedrazzoli M,D'Agostino C,Elia CA,Massenzio F,Lonati E,Mauri M,Rizzi L,Molteni L,Bresciani E,Dander E,D'Amico G,Bulbarelli A,Torsello A,Matteoli M,Buffelli M,Coco S
Tue Sep 01 00:00:00 EDT 2020
The critical role of CD4+ T cells in PD-1 blockade against MHC-II-expressing tumors such as classic Hodgkin lymphoma.
Blood advances
Nagasaki J,Togashi Y,Sugawara T,Itami M,Yamauchi N,Yuda J,Sugano M,Ohara Y,Minami Y,Nakamae H,Hino M,Takeuchi M,Nishikawa H
Tue Sep 08 00:00:00 EDT 2020
Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.
PLoS pathogens
Place DE,Briard B,Samir P,Karki R,Bhattacharya A,Guy CS,Peters JL,Frase S,Vogel P,Neale G,Yamamoto M,Kanneganti TD
315-05 was used in Sample Preparation to show that type I interferon (IFN) restricts macrophage multinucleated giant cell (MNGC) formation during B. thailandensis infection.
Sun Mar 01 00:00:00 EST 2020
Heme protects intestinal mucosal barrier in DSS-induced colitis through regulating macrophage polarization in both HO-1-dependent and HO-1-independent way.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wu Y,Wu B,Zhang Z,Lu H,Fan C,Qi Q,Gao Y,Li H,Feng C,Zuo J,Tang W
Mon Jun 01 00:00:00 EDT 2020
Suppression of Mll1-Complex by Stat3/Cebpβ-Induced miR-21a/21b/181b Maintains the Accumulation, Homeostasis, and Immunosuppressive Function of Polymorphonuclear Myeloid-Derived Suppressor Cells.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Z,Huang X,Wang E,Huang Y,Yang R
Mon Jun 15 00:00:00 EDT 2020
Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ.
Journal of immunology (Baltimore, Md. : 1950)
Kidder K,Bian Z,Shi L,Liu Y
Sun Nov 15 00:00:00 EST 2020
4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis.
Journal of immunology (Baltimore, Md. : 1950)
Miki H,Han KH,Scott D,Croft M,Kang YJ
Wed Apr 01 00:00:00 EDT 2020
BHLHE40 Promotes TH2 Cell-Mediated Antihelminth Immunity and Reveals Cooperative CSF2RB Family Cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Jarjour NN,Bradstreet TR,Schwarzkopf EA,Cook ME,Lai CW,Huang SC,Taneja R,Stappenbeck TS,Van Dyken SJ,Urban JF,Edelson BT
Sat Feb 15 00:00:00 EST 2020
Cancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma.
Journal of immunology (Baltimore, Md. : 1950)
Johnson AM,Bullock BL,Neuwelt AJ,Poczobutt JM,Kaspar RE,Li HY,Kwak JW,Hopp K,Weiser-Evans MCM,Heasley LE,Schenk EL,Clambey ET,Nemenoff RA
315-05 was used in Flow cytometry/Cell sorting to examine the effect of cancer cell-specific MHC class II (csMHCII) expression in lung adenocarcinoma on T cell recruitment to tumors and response to anti-PD-1 therapy using two orthotopic immunocompetent murine models of non-small cell lung cancer: CMT167 (CMT) and Lewis lung carcinoma (LLC).
Wed Apr 15 00:00:00 EDT 2020
Cancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma.
Journal of immunology (Baltimore, Md. : 1950)
Johnson AM,Bullock BL,Neuwelt AJ,Poczobutt JM,Kaspar RE,Li HY,Kwak JW,Hopp K,Weiser-Evans MCM,Heasley LE,Schenk EL,Clambey ET,Nemenoff RA
315-05 was used in Flow cytometry/Cell sorting to examine the effect of cancer cell-specific MHC class II (csMHCII) expression in lung adenocarcinoma on T cell recruitment to tumors and response to anti-PD-1 therapy using two orthotopic immunocompetent murine models of non-small cell lung cancer: CMT167 (CMT) and Lewis lung carcinoma (LLC).
Wed Apr 15 00:00:00 EDT 2020
Mycobacterial Cord Factor Reprograms the Macrophage Response to IFN-γ towards Enhanced Inflammation yet Impaired Antigen Presentation and Expression of GBP1.
Journal of immunology (Baltimore, Md. : 1950)
Huber A,Killy B,Grummel N,Bodendorfer B,Paul S,Wiesmann V,Naschberger E,Zimmer J,Wirtz S,Schleicher U,Vera J,Ekici AB,Dalpke A,Lang R
Tue Sep 15 00:00:00 EDT 2020
IFNs Drive Development of Novel IL-15-Responsive Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Gordon SM,Nishiguchi MA,Chase JM,Mani S,Mainigi MA,Behrens EM
Sat Aug 15 00:00:00 EDT 2020
Aminooxyacetic acid attenuates post-infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice.
Journal of cellular and molecular medicine
Zhao P,Zhou W,Zhang Y,Li J,Zhao Y,Pan L,Shen Z,Chen W,Hui J
Sat Feb 01 00:00:00 EST 2020
Long non-coding RNA AK085865 ablation confers susceptibility to viral myocarditis by regulating macrophage polarization.
Journal of cellular and molecular medicine
Zhang Y,Li X,Kong X,Zhang M,Wang D,Liu Y,Lv K
Fri May 01 00:00:00 EDT 2020
Inhibition of TIM-4 protects against cerebral ischaemia-reperfusion injury.
Journal of cellular and molecular medicine
Zheng L,Huang Y,Wang X,Wang X,Chen W,Cheng W,Pan C
Wed Jan 01 00:00:00 EST 2020
Low-level laser therapy 810-nm up-regulates macrophage secretion of neurotrophic factors via PKA-CREB and promotes neuronal axon regeneration in vitro.
Journal of cellular and molecular medicine
Zhang J,Sun J,Zheng Q,Hu X,Wang Z,Liang Z,Li K,Song J,Ding T,Shen X,Zhang J,Qiao L
Wed Jan 01 00:00:00 EST 2020
Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism.
American journal of physiology. Cell physiology
Liu F,Wang X,Geng H,Bu HF,Wang P,De Plaen IG,Yang H,Qian J,Tan XD
Wed Apr 01 00:00:00 EDT 2020
Single-cell RNA sequencing study of retinal immune regulators identified CD47 and CD59a expression in photoreceptors-Implications in subretinal immune regulation.
Journal of neuroscience research
Liu J,Tang M,Harkin K,Du X,Luo C,Chen M,Xu H
315-05 was used in Cell Culture to suggest that photoreceptors express immune regulatory molecules and may have the potential to regulate immune activation in the outer retina/subretinal space under pathophysiological conditions.
Wed Jul 01 00:00:00 EDT 2020
Berberine ameliorates renal impairment and inhibits podocyte dysfunction by targeting the phosphatidylinositol 3-kinase-protein kinase B pathway in diabetic rats.
Journal of diabetes investigation
Ni WJ,Zhou H,Ding HH,Tang LQ
Sun Mar 01 00:00:00 EST 2020
Curcumin prevents osteocyte apoptosis by inhibiting M1-type macrophage polarization in mice model of glucocorticoid-associated osteonecrosis of the femoral head.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Jin S,Meng C,He Y,Wang X,Zhang Q,Wang Z,Huang W,Wang H
Tue Sep 01 00:00:00 EDT 2020
Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition.
Oncoimmunology
Cervera-Carrascon V,Quixabeira DCA,Santos JM,Havunen R,Zafar S,Hemminki O,Heiniö C,Munaro E,Siurala M,Sorsa S,Mirtti T,Järvinen P,Mildh M,Nisen H,Rannikko A,Anttila M,Kanerva A,Hemminki A
315-05 was used in In vitro experiments to show how a viral platform coding for TNFa and IL-2 has a considerable impact on the immune tumor microenvironment, which leads to higher responses in the context of anti-PD-L1 checkpoint inhibition.
Fri May 22 00:00:00 EDT 2020
Glycogen metabolism regulates macrophage-mediated acute inflammatory responses.
Nature communications
Ma J,Wei K,Liu J,Tang K,Zhang H,Zhu L,Chen J,Li F,Xu P,Chen J,Liu J,Fang H,Tang L,Wang D,Zeng L,Sun W,Xie J,Liu Y,Huang B
Tue Apr 14 00:00:00 EDT 2020
Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms.
Journal for immunotherapy of cancer
Neuwelt AJ,Kimball AK,Johnson AM,Arnold BW,Bullock BL,Kaspar RE,Kleczko EK,Kwak JW,Wu MH,Heasley LE,Doebele RC,Li HY,Nemenoff RA,Clambey ET
315-05 was used in In vitro experiments to identify therapeutic targets that can be manipulated in order to enhance cancer-cell-specific MHC II expression.
Wed Apr 01 00:00:00 EDT 2020
CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response.
Cell reports
Bromley SK,Akbaba H,Mani V,Mora-Buch R,Chasse AY,Sama A,Luster AD
315-05 was used in In vitro experiments to study the requirement for CD49a in the formation, localization, persistence, and function of cutaneous CD8+ tissue-resident memory T cells.
Tue Sep 01 00:00:00 EDT 2020
Inhibition of mitochondrial oxidative metabolism attenuates EMCV replication and protects β-cells from virally mediated lysis.
The Journal of biological chemistry
Stafford JD,Shaheen ZR,Yeo CT,Corbett JA
Fri Dec 04 00:00:00 EST 2020
Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo.
Scientific reports
Cai S,Choi JY,Borges TJ,Zhang H,Miao J,Ichimura T,Li X,Xu S,Chu P,Eskandari SK,Allos H,Alhaddad JB,Muhsin SA,Yatim K,Riella LV,Sage PT,Chandraker AK,Azzi JR
Fri Aug 28 00:00:00 EDT 2020
The secondary bile acids, ursodeoxycholic acid and lithocholic acid, protect against intestinal inflammation by inhibition of epithelial apoptosis.
Physiological reports
Lajczak-McGinley NK,Porru E,Fallon CM,Smyth J,Curley C,McCarron PA,Tambuwala MM,Roda A,Keely SJ
Mon Jun 01 00:00:00 EDT 2020
Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes.
bioRxiv : the preprint server for biology
Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD
315-05 was used in In vitro experiments to reveal that blocking the COVID-19 cytokine-mediated inflammatory cell death signaling pathway identified in this study may benefit patients with COVID-19 or other cytokine storm-driven syndromes by limiting inflammation and tissue damage.
Fri Nov 13 00:00:00 EST 2020
Neurons promote encephalitogenic CD4+ lymphocyte infiltration in experimental autoimmune encephalomyelitis.
Scientific reports
Nakazato Y,Fujita Y,Nakazato M,Yamashita T
Thu Apr 30 00:00:00 EDT 2020
Linagliptin affects IRS1/Akt signaling and prevents high glucose-induced apoptosis in podocytes.
Scientific reports
Mima A,Yasuzawa T,Nakamura T,Ueshima S
Wed Apr 01 00:00:00 EDT 2020
Typically inhibiting USP14 promotes autophagy in M1-like macrophages and alleviates CLP-induced sepsis.
Cell death & disease
Xu F,Ma Y,Huang W,Gao J,Guo M,Li J,Kong L,Liang G,Du R,Xu Q,Wu X
Thu Aug 20 00:00:00 EDT 2020
Effective Nephroprotection Against Acute Kidney Injury with a Star-Shaped Polyglutamate-Curcuminoid Conjugate.
Scientific reports
Córdoba-David G,Duro-Castano A,Castelo-Branco RC,González-Guerrero C,Cannata P,Sanz AB,Vicent MJ,Ortiz A,Ramos AM
Thu Feb 06 00:00:00 EST 2020
miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions.
eLife
Orefice NS,Guillemot-Legris O,Capasso R,Bottemanne P,Hantraye P,Caraglia M,Orefice G,Alhouayek M,Muccioli GG
315-05 was used in In vivo experiments to use a mouse model to recapitulate the human pathology characterized by autoimmune heterogeneity and the presence of cortical lesions which could be used for the study of both miRNA involvement and cortical lesion formation in disease pathogenesis.
Thu Sep 17 00:00:00 EDT 2020
Poor outcome with anti-programmed death-ligand 1 (PD-L1) antibody due to poor pharmacokinetic properties in PD-1/PD-L1 blockade-sensitive mouse models.
Journal for immunotherapy of cancer
Kurino T,Matsuda R,Terui A,Suzuki H,Kokubo T,Uehara T,Arano Y,Hisaka A,Hatakeyama H
315-05 was used in In vitro experiments to study murine breast MM48 and colon MC38 xenografts to analyze the pharmacological activity of antiprogrammed cell death protein 1 (aPD-1) and antiprogrammed death-ligand 1 (aPD-L1) monoclonal antibodies (mAbs).
Sat Feb 01 00:00:00 EST 2020
TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.
Cell reports
Fuster JJ,Zuriaga MA,Zorita V,MacLauchlan S,Polackal MN,Viana-Huete V,Ferrer-Pérez A,Matesanz N,Herrero-Cervera A,Sano S,Cooper MA,González-Navarro H,Walsh K
315-05 was used in Cell Culture to show that inactivating mutations in the epigenetic regulator TET2, which lead to clonal hematopoiesis, aggravate age- and obesity-related insulin resistance in mice.
Tue Oct 27 00:00:00 EDT 2020
Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
Scientific reports
Svendsen P,Etzerodt A,Deleuran BW,Moestrup SK
Fri Jul 24 00:00:00 EDT 2020
Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH.
Redox biology
Xu F,Guo M,Huang W,Feng L,Zhu J,Luo K,Gao J,Zheng B,Kong LD,Pang T,Wu X,Xu Q
315-05 was used in In vitro experiments to associate Annexin A5 with the special effect on hepatic macrophage phenotype shift from M1 to M2.
Tue Sep 01 00:00:00 EDT 2020
Multi-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogramming.
Cell death & disease
Yan K,Da TT,Bian ZH,He Y,Liu MC,Liu QZ,Long J,Li L,Gao CY,Yang SH,Zhao ZB,Lian ZX
Thu Sep 24 00:00:00 EDT 2020
Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein.
Journal of neuroinflammation
Li N,Stewart T,Sheng L,Shi M,Cilento EM,Wu Y,Hong JS,Zhang J
315-05 was used in In vitro experiments to examine the potential role of monomeric α-Syn in mediating microglia polarization to develop further insights into the connection between α-Syn, neuroinflammation, and Parkinson’s disease pathogenesis.
Thu Sep 17 00:00:00 EDT 2020
Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming.
Nature communications
Cheung KCP,Fanti S,Mauro C,Wang G,Nair AS,Fu H,Angeletti S,Spoto S,Fogolari M,Romano F,Aksentijevic D,Liu W,Li B,Cheng L,Jiang L,Vuononvirta J,Poobalasingam TR,Smith DM,Ciccozzi M,Solito E,Marelli-Berg FM
Fri Jul 17 00:00:00 EDT 2020
Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis.
Scientific reports
Pai CH,Lin SR,Liu CH,Pan SY,Hsu H,Chen YT,Yen CT,Yu IS,Wu HL,Lin SL,Lin SW
Thu Oct 08 00:00:00 EDT 2020
Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation.
Nature communications
Li ZL,Zhang HL,Huang Y,Huang JH,Sun P,Zhou NN,Chen YH,Mai J,Wang Y,Yu Y,Zhou LH,Li X,Yang D,Peng XD,Feng GK,Tang J,Zhu XF,Deng R
Thu Jul 30 00:00:00 EDT 2020
Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice.
Scientific reports
Nelson AS,Maddaloni M,Abbott JR,Hoffman C,Akgul A,Ohland C,Gharaibeh RZ,Jobin C,Brusko TM,Pascual DW
Thu Apr 09 00:00:00 EDT 2020
Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer.
Scientific reports
Moufarrij S,Srivastava A,Gomez S,Hadley M,Palmer E,Austin PT,Chisholm S,Diab N,Roche K,Yu A,Li J,Zhu W,Lopez-Acevedo M,Villagra A,Chiappinelli KB
Wed Feb 26 00:00:00 EST 2020
Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer.
Scientific reports
Moufarrij S,Srivastava A,Gomez S,Hadley M,Palmer E,Austin PT,Chisholm S,Diab N,Roche K,Yu A,Li J,Zhu W,Lopez-Acevedo M,Villagra A,Chiappinelli KB
Wed Feb 26 00:00:00 EST 2020
Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages.
Nature communications
Wang Y,Sangaré LO,Paredes-Santos TC,Hassan MA,Krishnamurthy S,Furuta AM,Markus BM,Lourido S,Saeij JPJ
Fri Oct 16 00:00:00 EDT 2020
Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice.
Scientific reports
Wang J,Ortiz C,Fontenot L,Mukhopadhyay R,Xie Y,Law IKM,Shih DQ,Mattai SA,Li Z,Koon HW
Thu Jul 30 00:00:00 EDT 2020
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Cell
Ponzetta A,Carriero R,Carnevale S,Barbagallo M,Molgora M,Perucchini C,Magrini E,Gianni F,Kunderfranco P,Polentarutti N,Pasqualini F,Di Marco S,Supino D,Peano C,Cananzi F,Colombo P,Pilotti S,Alomar SY,Bonavita E,Galdiero MR,Garlanda C,Mantovani A,Jaillon S
315-05 was used in In vitro experiments to conclude that neutrophils driving UTCαβ polarization and type 1 immunity are essential for resistance against murine sarcomas and selected human tumors.
Thu Jul 11 00:00:00 EDT 2019
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.
Cell
Brown CC,Gudjonson H,Pritykin Y,Deep D,Lavallée VP,Mendoza A,Fromme R,Mazutis L,Ariyan C,Leslie C,Pe'er D,Rudensky AY
Thu Oct 31 00:00:00 EDT 2019
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.
Cell
Benci JL,Johnson LR,Choa R,Xu Y,Qiu J,Zhou Z,Xu B,Ye D,Nathanson KL,June CH,Wherry EJ,Zhang NR,Ishwaran H,Hellmann MD,Wolchok JD,Kambayashi T,Minn AJ
Thu Aug 08 00:00:00 EDT 2019
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.
Cell
Benci JL,Johnson LR,Choa R,Xu Y,Qiu J,Zhou Z,Xu B,Ye D,Nathanson KL,June CH,Wherry EJ,Zhang NR,Ishwaran H,Hellmann MD,Wolchok JD,Kambayashi T,Minn AJ
Thu Aug 08 00:00:00 EDT 2019
Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β.
Immunity
Komuczki J,Tuzlak S,Friebel E,Hartwig T,Spath S,Rosenstiel P,Waisman A,Opitz L,Oukka M,Schreiner B,Pelczar P,Becher B
Tue May 21 00:00:00 EDT 2019
High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation.
Immunity
Zhang D,Jin W,Wu R,Li J,Park SA,Tu E,Zanvit P,Xu J,Liu O,Cain A,Chen W
Tue Oct 15 00:00:00 EDT 2019
Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.
Immunity
Pai CS,Huang JT,Lu X,Simons DM,Park C,Chang A,Tamaki W,Liu E,Roybal KT,Seagal J,Chen M,Hagihara K,Wei XX,DuPage M,Kwek SS,Oh DY,Daud A,Tsai KK,Wu C,Zhang L,Fasso M,Sachidanandam R,Jayaprakash A,Lin I,Casbon AJ,Kinsbury GA,Fong L
Tue Feb 19 00:00:00 EST 2019
Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge.
Immunity
Hoyer FF,Naxerova K,Schloss MJ,Hulsmans M,Nair AV,Dutta P,Calcagno DM,Herisson F,Anzai A,Sun Y,Wojtkiewicz G,Rohde D,Frodermann V,Vandoorne K,Courties G,Iwamoto Y,Garris CS,Williams DL,Breton S,Brown D,Whalen M,Libby P,Pittet MJ,King KR,Weissleder R,Swirski FK,Nahrendorf M
Tue Nov 19 00:00:00 EST 2019
Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness.
Immunity
Wu J,Ma S,Sandhoff R,Ming Y,Hotz-Wagenblatt A,Timmerman V,Bonello-Palot N,Schlotter-Weigel B,Auer-Grumbach M,Seeman P,Löscher WN,Reindl M,Weiss F,Mah E,Weisshaar N,Madi A,Mohr K,Schlimbach T,Velasco Cárdenas RM,Koeppel J,Grünschläger F,Müller L,Baumeister M,Brügger B,Schmitt M,Wabnitz G,Samstag Y,Cui G
Tue May 21 00:00:00 EDT 2019
A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.
Immunity
Minutti CM,Modak RV,Macdonald F,Li F,Smyth DJ,Dorward DA,Blair N,Husovsky C,Muir A,Giampazolias E,Dobie R,Maizels RM,Kendall TJ,Griggs DW,Kopf M,Henderson NC,Zaiss DM
Tue Mar 19 00:00:00 EDT 2019
Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses.
Immunity
Ji L,Zhao X,Zhang B,Kang L,Song W,Zhao B,Xie W,Chen L,Hu X
Tue Aug 20 00:00:00 EDT 2019
Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis.
The Journal of clinical investigation
Hannemann N,Cao S,Eriksson D,Schnelzer A,Jordan J,Eberhardt M,Schleicher U,Rech J,Ramming A,Uebe S,Ekici A,Cañete JD,Chen X,Bäuerle T,Vera J,Bogdan C,Schett G,Bozec A
Tue Apr 16 00:00:00 EDT 2019
Tumor cell-intrinsic EPHA2 suppresses anti-tumor immunity by regulating PTGS2 (COX-2).
The Journal of clinical investigation
Markosyan N,Li J,Sun YH,Richman LP,Lin JH,Yan F,Quinones L,Sela Y,Yamazoe T,Gordon N,Tobias JW,Byrne KT,Rech AJ,FitzGerald GA,Stanger BZ,Vonderheide RH
Tue Jun 04 00:00:00 EDT 2019
The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors.
The Journal of experimental medicine
Železnjak J,Lisnić VJ,Popović B,Lisnić B,Babić M,Halenius A,L'Hernault A,Roviš TL,Hengel H,Erhard F,Redwood AJ,Vidal SM,Dölken L,Krmpotić A,Jonjić S
Mon Aug 05 00:00:00 EDT 2019
Tumour-associated macrophage-derived interleukin-1 mediates glioblastoma-associated cerebral oedema.
Brain : a journal of neurology
Herting CJ,Chen Z,Maximov V,Duffy A,Szulzewsky F,Shayakhmetov DM,Hambardzumyan D
315-05 was used in Sample Preparation to study how that dexamethasone blocks interleukin-1 production in both bone marrow-derived and brain resident macrophage populations following stimulation with lipopolysaccharide and interferon gamma.
Sun Dec 01 00:00:00 EST 2019
BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses.
The EMBO journal
Dey A,Yang W,Gegonne A,Nishiyama A,Pan R,Yagi R,Grinberg A,Finkelman FD,Pfeifer K,Zhu J,Singer D,Zhu J,Ozato K
Mon Apr 01 00:00:00 EDT 2019
Induction of brain-infiltrating T-bet-expressing B cells in multiple sclerosis.
Annals of neurology
van Langelaar J,Rijvers L,Janssen M,Wierenga-Wolf AF,Melief MJ,Siepman TA,de Vries HE,Unger PA,van Ham SM,Hintzen RQ,van Luijn MM
Thu Aug 01 00:00:00 EDT 2019
VISTA expressed in tumour cells regulates T cell function.
British journal of cancer
Mulati K,Hamanishi J,Matsumura N,Chamoto K,Mise N,Abiko K,Baba T,Yamaguchi K,Horikawa N,Murakami R,Taki M,Budiman K,Zeng X,Hosoe Y,Azuma M,Konishi I,Mandai M
Tue Jan 01 00:00:00 EST 2019
Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis.
Oncogene
Flood B,Manils J,Nulty C,Flis E,Kenealy S,Barber G,Fay J,Mills KHG,Kay EW,Creagh EM
315-05 was used in In vitro experiments to assess the importance of caspase-11 during colorectal tumour development.
Mon Apr 01 00:00:00 EDT 2019
Characterization of the Effects of Mesenchymal Stromal Cells on Mouse and Human Islet Function.
Stem cells translational medicine
Arzouni AA,Vargas-Seymour A,Dhadda PK,Rackham CL,Huang GC,Choudhary P,King AJF,Jones PM
Sun Sep 01 00:00:00 EDT 2019
Signaling and functional competency of neutrophils derived from bone-marrow cells expressing the ER-HOXB8 oncoprotein.
Journal of leukocyte biology
Saul S,Castelbou C,Fickentscher C,Demaurex N
Fri Nov 01 00:00:00 EDT 2019
Delayed resolution of bleomycin-induced pulmonary fibrosis in absence of MMP13 (collagenase 3).
American journal of physiology. Lung cellular and molecular physiology
Cabrera S,Maciel M,Hernández-Barrientos D,Calyeca J,Gaxiola M,Selman M,Pardo A
315-05 was used in In vitro experiments to establish that MMP13 plays an antifibrotic role and its activity is crucial in lung repair and restoration of tissue integrity during fibrosis resolution.
Wed May 01 00:00:00 EDT 2019
Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy.
Journal of cellular and molecular medicine
Gu AQ,Li DD,Wei DP,Liu YQ,Ji WH,Yang Y,Lin HY,Peng JP
Thu Aug 01 00:00:00 EDT 2019
Autocrine VEGF signalling on M2 macrophages regulates PD-L1 expression for immunomodulation of T cells.
Journal of cellular and molecular medicine
Lai YS,Wahyuningtyas R,Aui SP,Chang KT
Fri Feb 01 00:00:00 EST 2019
Leonurine suppresses neuroinflammation through promoting oligodendrocyte maturation.
Journal of cellular and molecular medicine
Jin M,Li Q,Gu Y,Wan B,Huang J,Xu X,Huang R,Zhang Y
Fri Feb 01 00:00:00 EST 2019
Magnetic Resonance Colonography Enables the Efficacy Assessment of Immune Checkpoint Inhibitors in an Orthotopic Colorectal Cancer Mouse Model.
Translational oncology
Chae YJ,Kim J,Heo H,Woo CW,Kim ST,Kim MJ,Choi JR,Kim DH,Woo DC,Kim KW,Choi Y
315-05 was used in Sample Preparation (FC/FACS) to study the feasibility of using magnetic resonance colonography (MRC) to evaluate the efficacy of an immune checkpoint inhibitor (ICI), an anti-PD-L1 antibody, in an orthotopic colorectal cancer mouse model.
Sun Sep 01 00:00:00 EDT 2019
Inhibition of protein nitration prevents cisplatin-induced inactivation of STAT3 and promotes anti-apoptotic signaling in organ of Corti cells.
Experimental cell research
Rosati R,Shahab M,Neumann WL,Jamesdaniel S
315-05 was used in Cell Culture to investigate the link between cisplatin-induced nitrative stress and STAT3-mediated apoptosis by using organ of Corti cell cultures.
Thu Aug 01 00:00:00 EDT 2019
Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy.
Cell reports
Renner K,Bruss C,Schnell A,Koehl G,Becker HM,Fante M,Menevse AN,Kauer N,Blazquez R,Hacker L,Decking SM,Bohn T,Faerber S,Evert K,Aigle L,Amslinger S,Landa M,Krijgsman O,Rozeman EA,Brummer C,Siska PJ,Singer K,Pektor S,Miederer M,Peter K,Gottfried E,Herr W,Marchiq I,Pouyssegur J,Roush WR,Ong S,Warren S,Pukrop T,Beckhove P,Lang SA,Bopp T,Blank CU,Cleveland JL,Oefner PJ,Dettmer K,Selby M,Kreutz M
315-05 was used in Flow cytometry/Cell sorting to report that melanoma patients with high expression of glycolysis-related genes show a worse progression free survival upon anti-PD1 treatment and support the rationale for targeting glycolysis in patients with high glycolytic tumors together with checkpoint inhibitors in clinical trials.
Tue Oct 01 00:00:00 EDT 2019
Blockade of microglial Cav1.2 Ca2+ channel exacerbates the symptoms in a Parkinson's disease model.
Scientific reports
Wang X,Saegusa H,Huntula S,Tanabe T
Mon Jun 24 00:00:00 EDT 2019
Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti-PD-1 response in NSCLC.
Life science alliance
Bullock BL,Kimball AK,Poczobutt JM,Neuwelt AJ,Li HY,Johnson AM,Kwak JW,Kleczko EK,Kaspar RE,Wagner EK,Hopp K,Schenk EL,Weiser-Evans MC,Clambey ET,Nemenoff RA
315-05 was used in In vitro experiments to demonstrate that targeted enhancement of tumor-intrinsic IFNγ signaling can induce a cascade of changes associated with increased therapeutic vulnerability.
Sat Jun 01 00:00:00 EDT 2019
Development of Adamantane-Conjugated TLR7/8 Agonists for Supramolecular Delivery and Cancer Immunotherapy.
Theranostics
Rodell CB,Ahmed MS,Garris CS,Pittet MJ,Weissleder R
315-05 was used in Cell Culture to describe the development of adamantane-conjugated TLR7/8 agonists for supramolecular delivery and cancer immunotherapy.
Mon Sep 14 00:00:00 EDT 2020
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
Cell reports
Bailey JD,Diotallevi M,Nicol T,McNeill E,Shaw A,Chuaiphichai S,Hale A,Starr A,Nandi M,Stylianou E,McShane H,Davis S,Fischer R,Kessler BM,McCullagh J,Channon KM,Crabtree MJ
315-05 was used in In vitro experiments to investigate nitrogen oxide in mitochondrial respiration for macrophage activation.
Tue Jul 02 00:00:00 EDT 2019
Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer.
Cell reports
Di Mitri D,Mirenda M,Vasilevska J,Calcinotto A,Delaleu N,Revandkar A,Gil V,Boysen G,Losa M,Mosole S,Pasquini E,D'Antuono R,Masetti M,Zagato E,Chiorino G,Ostano P,Rinaldi A,Gnetti L,Graupera M,Martins Figueiredo Fonseca AR,Pereira Mestre R,Waugh D,Barry S,De Bono J,Alimonti A
315-05 was used in Cell Culture to identify tumor-associated macrophages as targets in prostate cancer and describe a therapeutic strategy based on CXCR2 blockade to harness anti-tumorigenic potential of macrophages against this disease.
Tue Aug 20 00:00:00 EDT 2019
The silencing of indoleamine 2,3-dioxygenase 1 (IDO1) in dendritic cells by siRNA-loaded lipid nanoparticles enhances cell-based cancer immunotherapy.
Scientific reports
Endo R,Nakamura T,Kawakami K,Sato Y,Harashima H
Mon Aug 05 00:00:00 EDT 2019
Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24.
Nature communications
Yu T,Gan S,Zhu Q,Dai D,Li N,Wang H,Chen X,Hou D,Wang Y,Pan Q,Xu J,Zhang X,Liu J,Pei S,Peng C,Wu P,Romano S,Mao C,Huang M,Zhu X,Shen K,Qin J,Xiao Y
Wed Sep 25 00:00:00 EDT 2019
Exosome-Guided Phenotypic Switch of M1 to M2 Macrophages for Cutaneous Wound Healing.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Kim H,Wang SY,Kwak G,Yang Y,Kwon IC,Kim SH
Wed Oct 16 00:00:00 EDT 2019
Nerve modulation therapy in gouty arthritis: targeting increased sFRP2 expression in dorsal root ganglion regulates macrophage polarization and alleviates endothelial damage.
Theranostics
Mei J,Zhou F,Qiao H,Li H,Tang T
315-05 was used in In vitro experiments to investigate the significance of sensory neuron neuropeptides and chemokine signals on inflammation-induced macrophages polarization during gouty arthritis.
Mon Sep 14 00:00:00 EDT 2020
Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells.
Cell death & disease
Vig S,Buitinga M,Rondas D,Crèvecoeur I,van Zandvoort M,Waelkens E,Eizirik DL,Gysemans C,Baatsen P,Mathieu C,Overbergh L
315-05 was used in Cell Culture to study the translocation of 78-kDa glucose-regulated protein to the surface of human EndoC-βH1 cells and primary human islets upon cytokine exposure.
Fri Apr 05 00:00:00 EDT 2019
Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells.
Cell death & disease
Vig S,Buitinga M,Rondas D,Crèvecoeur I,van Zandvoort M,Waelkens E,Eizirik DL,Gysemans C,Baatsen P,Mathieu C,Overbergh L
315-05 was used in Cell Culture to study the translocation of 78-kDa glucose-regulated protein to the surface of human EndoC-βH1 cells and primary human islets upon cytokine exposure.
Fri Apr 05 00:00:00 EDT 2019
Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson's disease.
Cell death & disease
Dionísio PA,Oliveira SR,Gaspar MM,Gama MJ,Castro-Caldas M,Amaral JD,Rodrigues CMP
Tue Nov 05 00:00:00 EST 2019
Lipopolysaccharide-anchored macrophages hijack tumor microtube networks for selective drug transport and augmentation of antitumor effects in orthotopic lung cancer.
Theranostics
Guo L,Zhang Y,Wei R,Wang C,Feng M
315-05 was used in Cell Culture to show that our results can be used to select the most suitable model for the study of trophoblast development, function and pathology.
Thu Oct 15 00:00:00 EDT 2020
Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses.
Scientific reports
Minshawi F,White MRH,Muller W,Humphreys N,Jackson D,Campbell BJ,Adamson A,Papoutsopoulou S
Thu Jan 17 00:00:00 EST 2019
Macrophage Phosphoproteome Analysis Reveals MINCLE-dependent and -independent Mycobacterial Cord Factor Signaling.
Molecular & cellular proteomics : MCP
Hansen M,Peltier J,Killy B,Amin B,Bodendorfer B,Härtlova A,Uebel S,Bosmann M,Hofmann J,Büttner C,Ekici AB,Kuttke M,Franzyk H,Foged C,Beer-Hammer S,Schabbauer G,Trost M,Lang R
Mon Apr 01 00:00:00 EDT 2019
Phase-specific functions of macrophages determine injury-mediated corneal hem- and lymphangiogenesis.
Scientific reports
Kiesewetter A,Cursiefen C,Eming SA,Hos D
Tue Jan 22 00:00:00 EST 2019
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
Nature
Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C
Sat Dec 01 00:00:00 EST 2018
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis.
Nature
Peltzer N,Darding M,Montinaro A,Draber P,Draberova H,Kupka S,Rieser E,Fisher A,Hutchinson C,Taraborrelli L,Hartwig T,Lafont E,Haas TL,Shimizu Y,Böiers C,Sarr A,Rickard J,Alvarez-Diaz S,Ashworth MT,Beal A,Enver T,Bertin J,Kaiser W,Strasser A,Silke J,Bouillet P,Walczak H
Tue May 01 00:00:00 EDT 2018
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis.
Nature
Peltzer N,Darding M,Montinaro A,Draber P,Draberova H,Kupka S,Rieser E,Fisher A,Hutchinson C,Taraborrelli L,Hartwig T,Lafont E,Haas TL,Shimizu Y,Böiers C,Sarr A,Rickard J,Alvarez-Diaz S,Ashworth MT,Beal A,Enver T,Bertin J,Kaiser W,Strasser A,Silke J,Bouillet P,Walczak H
Tue May 01 00:00:00 EDT 2018
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.
Nature
Xu M,Pokrovskii M,Ding Y,Yi R,Au C,Harrison OJ,Galan C,Belkaid Y,Bonneau R,Littman DR
Thu Feb 15 00:00:00 EST 2018
Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
Nature
Bambouskova M,Gorvel L,Lampropoulou V,Sergushichev A,Loginicheva E,Johnson K,Korenfeld D,Mathyer ME,Kim H,Huang LH,Duncan D,Bregman H,Keskin A,Santeford A,Apte RS,Sehgal R,Johnson B,Amarasinghe GK,Soares MP,Satoh T,Akira S,Hai T,de Guzman Strong C,Auclair K,Roddy TP,Biller SA,Jovanovic M,Klechevsky E,Stewart KM,Randolph GJ,Artyomov MN
Sun Apr 01 00:00:00 EDT 2018
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response.
Nature
Chen G,Huang AC,Zhang W,Zhang G,Wu M,Xu W,Yu Z,Yang J,Wang B,Sun H,Xia H,Man Q,Zhong W,Antelo LF,Wu B,Xiong X,Liu X,Guan L,Li T,Liu S,Yang R,Lu Y,Dong L,McGettigan S,Somasundaram R,Radhakrishnan R,Mills G,Lu Y,Kim J,Chen YH,Dong H,Zhao Y,Karakousis GC,Mitchell TC,Schuchter LM,Herlyn M,Wherry EJ,Xu X,Guo W
Wed Aug 01 00:00:00 EDT 2018
Vitamin D Switches BAF Complexes to Protect β Cells.
Cell
Wei Z,Yoshihara E,He N,Hah N,Fan W,Pinto AFM,Huddy T,Wang Y,Ross B,Estepa G,Dai Y,Ding N,Sherman MH,Fang S,Zhao X,Liddle C,Atkins AR,Yu RT,Downes M,Evans RM
Thu May 17 00:00:00 EDT 2018
Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.
Cell
Barrow AD,Edeling MA,Trifonov V,Luo J,Goyal P,Bohl B,Bando JK,Kim AH,Walker J,Andahazy M,Bugatti M,Melocchi L,Vermi W,Fremont DH,Cox S,Cella M,Schmedt C,Colonna M
Thu Jan 25 00:00:00 EST 2018
Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens.
Cell
Wroblewska A,Dhainaut M,Ben-Zvi B,Rose SA,Park ES,Amir ED,Bektesevic A,Baccarini A,Merad M,Rahman AH,Brown BD
Thu Nov 01 00:00:00 EDT 2018
Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response.
Cell
Xu X,Xu J,Wu J,Hu Y,Han Y,Gu Y,Zhao K,Zhang Q,Liu X,Liu J,Liu B,Cao X
Thu Nov 15 00:00:00 EST 2018
EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens.
Nature methods
Squadrito ML,Cianciaruso C,Hansen SK,De Palma M
Thu Mar 01 00:00:00 EST 2018
T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.
Immunity
Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W
Tue Apr 17 00:00:00 EDT 2018
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.
Immunity
Garris CS,Arlauckas SP,Kohler RH,Trefny MP,Garren S,Piot C,Engblom C,Pfirschke C,Siwicki M,Gungabeesoon J,Freeman GJ,Warren SE,Ong S,Browning E,Twitty CG,Pierce RH,Le MH,Algazi AP,Daud AI,Pai SI,Zippelius A,Weissleder R,Pittet MJ
Tue Dec 18 00:00:00 EST 2018
The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory.
Immunity
Daniel B,Nagy G,Czimmerer Z,Horvath A,Hammers DW,Cuaranta-Monroy I,Poliska S,Tzerpos P,Kolostyak Z,Hays TT,Patsalos A,Houtman R,Sauer S,Francois-Deleuze J,Rastinejad F,Balint BL,Sweeney HL,Nagy L
Tue Oct 16 00:00:00 EDT 2018
Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.
Immunity
Trompette A,Gollwitzer ES,Pattaroni C,Lopez-Mejia IC,Riva E,Pernot J,Ubags N,Fajas L,Nicod LP,Marsland BJ
Tue May 15 00:00:00 EDT 2018
TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer.
Cancer cell
de Mingo Pulido Á,Gardner A,Hiebler S,Soliman H,Rugo HS,Krummel MF,Coussens LM,Ruffell B
Mon Jan 08 00:00:00 EST 2018
Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade.
The Journal of clinical investigation
Hsu J,Hodgins JJ,Marathe M,Nicolai CJ,Bourgeois-Daigneault MC,Trevino TN,Azimi CS,Scheer AK,Randolph HE,Thompson TW,Zhang L,Iannello A,Mathur N,Jardine KE,Kirn GA,Bell JC,McBurney MW,Raulet DH,Ardolino M
Mon Oct 01 00:00:00 EDT 2018
Endothelial chimerism and vascular sequestration protect pancreatic islet grafts from antibody-mediated rejection.
The Journal of clinical investigation
Chen CC,Pouliquen E,Broisat A,Andreata F,Racapé M,Bruneval P,Kessler L,Ahmadi M,Bacot S,Saison-Delaplace C,Marcaud M,Van Huyen JD,Loupy A,Villard J,Demuylder-Mischler S,Berney T,Morelon E,Tsai MK,Kolopp-Sarda MN,Koenig A,Mathias V,Ducreux S,Ghezzi C,Dubois V,Nicoletti A,Defrance T,Thaunat O
Tue Jan 02 00:00:00 EST 2018
Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy.
The Journal of clinical investigation
Hailemichael Y,Woods A,Fu T,He Q,Nielsen MC,Hasan F,Roszik J,Xiao Z,Vianden C,Khong H,Singh M,Sharma M,Faak F,Moore D,Dai Z,Anthony SM,Schluns KS,Sharma P,Engelhard VH,Overwijk WW
Mon Apr 02 00:00:00 EDT 2018
H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition.
The Journal of clinical investigation
Nancy P,Siewiera J,Rizzuto G,Tagliani E,Osokine I,Manandhar P,Dolgalev I,Clementi C,Tsirigos A,Erlebacher A
Tue Jan 02 00:00:00 EST 2018
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression.
The Journal of clinical investigation
Lin H,Wei S,Hurt EM,Green MD,Zhao L,Vatan L,Szeliga W,Herbst R,Harms PW,Fecher LA,Vats P,Chinnaiyan AM,Lao CD,Lawrence TS,Wicha M,Hamanishi J,Mandai M,Kryczek I,Zou W
Thu Feb 01 00:00:00 EST 2018
Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.
The Journal of experimental medicine
Song WM,Joshita S,Zhou Y,Ulland TK,Gilfillan S,Colonna M
Mon Mar 05 00:00:00 EST 2018
The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination.
The Journal of experimental medicine
Yu F,Sharma S,Jankovic D,Gurram RK,Su P,Hu G,Li R,Rieder S,Zhao K,Sun B,Zhu J
Mon Jul 02 00:00:00 EDT 2018
IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin.
The Journal of experimental medicine
Lane RS,Femel J,Breazeale AP,Loo CP,Thibault G,Kaempf A,Mori M,Tsujikawa T,Chang YH,Lund AW
Mon Dec 03 00:00:00 EST 2018
Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation.
The Journal of experimental medicine
Arnold IC,Artola-Borán M,Tallón de Lara P,Kyburz A,Taube C,Ottemann K,van den Broek M,Yousefi S,Simon HU,Müller A
Mon Aug 06 00:00:00 EDT 2018
Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment.
The Journal of experimental medicine
Lee SH,Charmoy M,Romano A,Paun A,Chaves MM,Cope FO,Ralph DA,Sacks DL
Tue Jan 02 00:00:00 EST 2018
Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Krummel MF,Mahale JN,Uhl LFK,Hardison EA,Mujal AM,Mazet JM,Weber RJ,Gartner ZJ,Gérard A
Tue Nov 06 00:00:00 EST 2018
Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Laumet G,Edralin JD,Chiang AC,Dantzer R,Heijnen CJ,Kavelaars A
315-05 was used in Cell Culture to investigate the role of inflammation in depression recovery.
Sat Dec 01 00:00:00 EST 2018
Imaging Reporter Strategy to Monitor Gene Activation of Microglia Polarisation States under Stimulation.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Collmann FM,Pijnenburg R,Schneider G,Schäfer C,Folz-Donahue K,Kukat C,Hoehn M
315-05 was used in Sample Preparation (Western Blotting) to evaluate imaging promoter to monitor the activity of genes involved in microglia polarisation.
Sat Sep 01 00:00:00 EDT 2018
Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages.
Journal of lipid research
Kriska T,Thomas MJ,Falck JR,Campbell WB
Sun Apr 01 00:00:00 EDT 2018
Intratumoral Delivery of Interferonγ-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo.
Stem cells (Dayton, Ohio)
Relation T,Yi T,Guess AJ,La Perle K,Otsuru S,Hasgur S,Dominici M,Breuer C,Horwitz EM
Fri Jun 01 00:00:00 EDT 2018
Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-β-Mediated Tumor Immune Evasion.
Journal of immunology (Baltimore, Md. : 1950)
Ibrahim M,Scozzi D,Toth KA,Ponti D,Kreisel D,Menna C,De Falco E,D'Andrilli A,Rendina EA,Calogero A,Krupnick AS,Gelman AE
Mon Jan 15 00:00:00 EST 2018
Macrophages Switch Their Phenotype by Regulating Maf Expression during Different Phases of Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Kikuchi K,Iida M,Ikeda N,Moriyama S,Hamada M,Takahashi S,Kitamura H,Watanabe T,Hasegawa Y,Hase K,Fukuhara T,Sato H,Kobayashi EH,Suzuki T,Yamamoto M,Tanaka M,Asano K
Sun Jul 15 00:00:00 EDT 2018
The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis Infection.
Journal of immunology (Baltimore, Md. : 1950)
Olive AJ,Smith CM,Kiritsy MC,Sassetti CM
Sat Sep 15 00:00:00 EDT 2018
Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Imbrechts M,Avau A,Vandenhaute J,Malengier-Devlies B,Put K,Mitera T,Berghmans N,Burton O,Junius S,Liston A,de Somer L,Wouters C,Matthys P
Thu Nov 01 00:00:00 EDT 2018
Mesenchymal Stem Cells Recruit CCR2+ Monocytes To Suppress Allergic Airway Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Takeda K,Webb TL,Ning F,Shiraishi Y,Regan DP,Chow L,Smith MJ,Ashino S,Guth AM,Hopkins S,Gelfand EW,Dow S
Thu Feb 15 00:00:00 EST 2018
TGF-β1 Suppresses the Type I IFN Response and Induces Mitochondrial Dysfunction in Alveolar Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Grunwell JR,Yeligar SM,Stephenson S,Ping XD,Gauthier TW,Fitzpatrick AM,Brown LAS
Thu Mar 15 00:00:00 EDT 2018
Shaving Is an Epiphenomenon of Type I and II Anti-CD20-Mediated Phagocytosis, whereas Antigenic Modulation Limits Type I Monoclonal Antibody Efficacy.
Journal of immunology (Baltimore, Md. : 1950)
Dahal LN,Huang CY,Stopforth RJ,Mead A,Chan K,Bowater JX,Taylor MC,Narang P,Chan HTC,Kim JH,Vaughan AT,Forconi F,Beers SA
Wed Aug 15 00:00:00 EDT 2018
Golgi Phosphoprotein 2 Is a Novel Regulator of IL-12 Production and Macrophage Polarization.
Journal of immunology (Baltimore, Md. : 1950)
Zhang W,Kim H,Lv J,Zhao N,Ma X
Thu Feb 15 00:00:00 EST 2018
Mesenchymal stromal cell potency to treat acute kidney injury increased by ultrasound-activated interferon-γ/interleukin-10 axis.
Journal of cellular and molecular medicine
Burks SR,Nagle ME,Bresler MN,Kim SJ,Star RA,Frank JA
Sat Dec 01 00:00:00 EST 2018
Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus.
Nature communications
Kim DH,Park ES,Lee AR,Park S,Park YK,Ahn SH,Kang HS,Won JH,Ha YN,Jae B,Kim DS,Chung WC,Song MJ,Kim KH,Park SH,Kim SH,Kim KH
Thu Aug 16 00:00:00 EDT 2018
Chitinase 3-like-1 promotes intrahepatic activation of coagulation through induction of tissue factor in mice.
Hepatology (Baltimore, Md.)
Shan Z,Liu X,Chen Y,Wang M,Gao YR,Xu L,Dar WA,Lee CG,Elias JA,Castillo PD,Di Paola J,Ju C
315-05 was used in Cell Culture to demonstrate that Chi3l1, through induction of TF via mitogen-activated protein kinase activation, promotes IAOC and tissue injury.
Fri Jun 01 00:00:00 EDT 2018
CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema.
Nature communications
García Nores GD,Ly CL,Cuzzone DA,Kataru RP,Hespe GE,Torrisi JS,Huang JJ,Gardenier JC,Savetsky IL,Nitti MD,Yu JZ,Rehal S,Mehrara BJ
Thu May 17 00:00:00 EDT 2018
Eosinophils support adipocyte maturation and promote glucose tolerance in obesity.
Scientific reports
Lee EH,Itan M,Jang J,Gu HJ,Rozenberg P,Mingler MK,Wen T,Yoon J,Park SY,Roh JY,Choi CS,Park WJ,Munitz A,Jung Y
Mon Jul 02 00:00:00 EDT 2018
Cardiac (myo)fibroblasts modulate the migration of monocyte subsets.
Scientific reports
Pappritz K,Savvatis K,Koschel A,Miteva K,Tschöpe C,Van Linthout S
Tue Apr 03 00:00:00 EDT 2018
Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis.
Nature communications
Ryzhakov G,West NR,Franchini F,Clare S,Ilott NE,Sansom SN,Bullers SJ,Pearson C,Costain A,Vaughan-Jackson A,Goettel JA,Ermann J,Horwitz BH,Buti L,Lu X,Mukhopadhyay S,Snapper SB,Powrie F
Tue Sep 18 00:00:00 EDT 2018
CCL4 enhances preosteoclast migration and its receptor CCR5 downregulation by RANKL promotes osteoclastogenesis.
Cell death & disease
Lee D,Shin KJ,Kim DW,Yoon KA,Choi YJ,Lee BNR,Cho JY
Tue May 01 00:00:00 EDT 2018
The deubiquitinating enzyme UCHL1 negatively regulates the immunosuppressive capacity and survival of multipotent mesenchymal stromal cells.
Cell death & disease
Gu Y,Ding X,Huang J,Xue M,Zhang J,Wang Q,Yu H,Wang Y,Zhao F,Wang H,Jin M,Wu Y,Zhang Y
Tue May 01 00:00:00 EDT 2018
Detection of host pathways universally inhibited after Plasmodium yoelii infection for immune intervention.
Scientific reports
Xia L,Wu J,Pattaradilokrat S,Tumas K,He X,Peng YC,Huang R,Myers TG,Long CA,Wang R,Su XZ
Tue Oct 16 00:00:00 EDT 2018
Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin.
Nature communications
McNeill E,Stylianou E,Crabtree MJ,Harrington-Kandt R,Kolb AL,Diotallevi M,Hale AB,Bettencourt P,Tanner R,O'Shea MK,Matsumiya M,Lockstone H,Müller J,Fletcher HA,Greaves DR,McShane H,Channon KM
Thu Dec 20 00:00:00 EST 2018
Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model.
JCI insight
Flemming S,Luissint AC,Nusrat A,Parkos CA
315-05 was used in In vivo experiments to analyse leukocyte transepithelial migration using an in vivo murine colonic loop model.
Thu Oct 18 00:00:00 EDT 2018
Blimp-1/PRDM1 is a critical regulator of Type III Interferon responses in mammary epithelial cells.
Scientific reports
Elias S,Robertson EJ,Bikoff EK,Mould AW
Wed Jan 10 00:00:00 EST 2018
Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells.
The Journal of biological chemistry
Sweeny EA,Singh AB,Chakravarti R,Martinez-Guzman O,Saini A,Haque MM,Garee G,Dans PD,Hannibal L,Reddi AR,Stuehr DJ
Fri Sep 14 00:00:00 EDT 2018
Kir6.1/K-ATP channel modulates microglia phenotypes: implication in Parkinson's disease.
Cell death & disease
Du RH,Sun HB,Hu ZL,Lu M,Ding JH,Hu G
Wed Mar 14 00:00:00 EDT 2018
The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration.
Cell death & disease
Dollt C,Michel J,Kloss L,Melchers S,Schledzewski K,Becker K,Sauer A,Krewer A,Koll F,Schmieder A
Wed Sep 19 00:00:00 EDT 2018
C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease.
Nature communications
Dufour A,Bellac CL,Eckhard U,Solis N,Klein T,Kappelhoff R,Fortelny N,Jobin P,Rozmus J,Mark J,Pavlidis P,Dive V,Barbour SJ,Overall CM
Wed Jun 20 00:00:00 EDT 2018
Recombinant IFN-γ from the bank vole Myodes glareolus: a novel tool for research on rodent reservoirs of zoonotic pathogens.
Scientific reports
Torelli F,Zander S,Ellerbrok H,Kochs G,Ulrich RG,Klotz C,Seeber F
Mon Feb 12 00:00:00 EST 2018
Recombinant IFN-γ from the bank vole Myodes glareolus: a novel tool for research on rodent reservoirs of zoonotic pathogens.
Scientific reports
Torelli F,Zander S,Ellerbrok H,Kochs G,Ulrich RG,Klotz C,Seeber F
Mon Feb 12 00:00:00 EST 2018
Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop.
Nature communications
Liu Z,Qin Q,Wu C,Li H,Shou J,Yang Y,Gu M,Ma C,Lin W,Zou Y,Zhang Y,Ma F,Sun J,Wang X
Tue Jul 17 00:00:00 EDT 2018
Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis.
Cell death & disease
Tanabe S,Fujita Y,Ikuma K,Yamashita T
Wed Oct 17 00:00:00 EDT 2018
Aberrant activation of Notch-1 signaling inhibits podocyte restoration after islet transplantation in a rat model of diabetic nephropathy.
Cell death & disease
He Y,Zhang M,Wu Y,Jiang H,Fu H,Cai Y,Xu Z,Liu C,Chen B,Yang T
Thu Sep 20 00:00:00 EDT 2018
Imatinib reduces non-alcoholic fatty liver disease in obese mice by targeting inflammatory and lipogenic pathways in macrophages and liver.
Scientific reports
AlAsfoor S,Rohm TV,Bosch AJT,Dervos T,Calabrese D,Matter MS,Weber A,Cavelti-Weder C
Wed Oct 17 00:00:00 EDT 2018
Loss of NDRG2 in liver microenvironment inhibits cancer liver metastasis by regulating tumor associate macrophages polarization.
Cell death & disease
Li M,Lai X,Zhao Y,Zhang Y,Li M,Li D,Kong J,Zhang Y,Jing P,Li H,Qin H,Shen L,Yao L,Li J,Dou K,Zhang J
Wed Feb 14 00:00:00 EST 2018
Evaluating protective and therapeutic effects of alpha-lipoic acid on cisplatin-induced ototoxicity.
Cell death & disease
Kim KH,Lee B,Kim YR,Kim MA,Ryu N,Jung DJ,Kim UK,Baek JI,Lee KY
Wed Aug 01 00:00:00 EDT 2018
Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent M2b polarization.
Stem cell research & therapy
Philipp D,Suhr L,Wahlers T,Choi YH,Paunel-Görgülü A
Thu Oct 25 00:00:00 EDT 2018
Sox9 regulates cell state and activity of embryonic mouse mammary progenitor cells.
Communications biology
Kogata N,Bland P,Tsang M,Oliemuller E,Lowe A,Howard BA
Wed Mar 04 00:00:00 EST 2020
Crosstalk between hepatic tumor cells and macrophages via Wnt/β-catenin signaling promotes M2-like macrophage polarization and reinforces tumor malignant behaviors.
Cell death & disease
Yang Y,Ye YC,Chen Y,Zhao JL,Gao CC,Han H,Liu WC,Qin HY
Wed Jul 18 00:00:00 EDT 2018
Magnesium enhances the chondrogenic differentiation of mesenchymal stem cells by inhibiting activated macrophage-induced inflammation.
Scientific reports
Hu T,Xu H,Wang C,Qin H,An Z
Wed Feb 21 00:00:00 EST 2018
Induction of alopecia areata in C3H/HeJ mice using polyinosinic-polycytidylic acid (poly[I:C]) and interferon-gamma.
Scientific reports
Shin JM,Choi DK,Sohn KC,Koh JW,Lee YH,Seo YJ,Kim CD,Lee JH,Lee Y
Tue Aug 21 00:00:00 EDT 2018
Replication-Transcription Conflicts Generate R-Loops that Orchestrate Bacterial Stress Survival and Pathogenesis.
Cell
Lang KS,Hall AN,Merrikh CN,Ragheb M,Tabakh H,Pollock AJ,Woodward JJ,Dreifus JE,Merrikh H
Thu Aug 10 00:00:00 EDT 2017
Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.
Immunity
Glodde N,Bald T,van den Boorn-Konijnenberg D,Nakamura K,O'Donnell JS,Szczepanski S,Brandes M,Eickhoff S,Das I,Shridhar N,Hinze D,Rogava M,van der Sluis TC,Ruotsalainen JJ,Gaffal E,Landsberg J,Ludwig KU,Wilhelm C,Riek-Burchardt M,Müller AJ,Gebhardt C,Scolyer RA,Long GV,Janzen V,Teng MWL,Kastenmüller W,Mazzone M,Smyth MJ,Tüting T,Hölzel M
Tue Oct 17 00:00:00 EDT 2017
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
Immunity
Kishore M,Cheung KCP,Fu H,Bonacina F,Wang G,Coe D,Ward EJ,Colamatteo A,Jangani M,Baragetti A,Matarese G,Smith DM,Haas R,Mauro C,Wraith DC,Okkenhaug K,Catapano AL,De Rosa V,Norata GD,Marelli-Berg FM
315-05 was used in In vitro experiments to demonstrate that glucokinase-dependent glycolysis regulates regulatory T cell migration.
Tue Nov 21 00:00:00 EST 2017
Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.
Immunity
Chang YH,Wang KC,Chu KL,Clouthier DL,Tran AT,Torres Perez MS,Zhou AC,Abdul-Sater AA,Watts TH
Tue Nov 21 00:00:00 EST 2017
Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade.
Cancer cell
Saha D,Martuza RL,Rabkin SD
Mon Aug 14 00:00:00 EDT 2017
IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance.
Cell host & microbe
Tsai PY,Zhang B,He WQ,Zha JM,Odenwald MA,Singh G,Tamura A,Shen L,Sailer A,Yeruva S,Kuo WT,Fu YX,Tsukita S,Turner JR
315-05 was used in Cell Culture to investigate the pathogenic effects of diarrhea.
Wed Jun 14 00:00:00 EDT 2017
Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis.
The Journal of clinical investigation
Koyanagi N,Imai T,Shindo K,Sato A,Fujii W,Ichinohe T,Takemura N,Kakuta S,Uematsu S,Kiyono H,Maruzuru Y,Arii J,Kato A,Kawaguchi Y
Mon Oct 02 00:00:00 EDT 2017
TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand.
The Journal of experimental medicine
Pattarini L,Trichot C,Bogiatzi S,Grandclaudon M,Meller S,Keuylian Z,Durand M,Volpe E,Madonna S,Cavani A,Chiricozzi A,Romanelli M,Hori T,Hovnanian A,Homey B,Soumelis V
Mon May 01 00:00:00 EDT 2017
An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.
The Journal of experimental medicine
Young HL,Rowling EJ,Bugatti M,Giurisato E,Luheshi N,Arozarena I,Acosta JC,Kamarashev J,Frederick DT,Cooper ZA,Reuben A,Gil J,Flaherty KT,Wargo JA,Vermi W,Smith MP,Wellbrock C,Hurlstone A
Mon Jun 05 00:00:00 EDT 2017
Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling.
Experimental & molecular medicine
Kim JC,Jung YS,Lee HY,Park JS,Bae YS
Fri Aug 25 00:00:00 EDT 2017
FcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells.
Frontiers in immunology
Pan YG,Yu YL,Lin CC,Lanier LL,Chu CL
315-05 was used in Cell Culture to further explore the role of the tyrosine-based activation motif-containing adaptors DAP12 and FcεRI γ-chain in C-type lectin receptor responses.
Wed Nov 20 00:00:00 EST 2019
Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy.
Oncogene
Castro BA,Flanigan P,Jahangiri A,Hoffman D,Chen W,Kuang R,De Lay M,Yagnik G,Wagner JR,Mascharak S,Sidorov M,Shrivastav S,Kohanbash G,Okada H,Aghi MK
315-05 was used in Cell Culture to study the mechanisms of resistance to anti-angiogenic therapies for cancer such as VEGF neutralizing antibody bevacizumab to show that bevacizumab resistance is driven by reduced migration inhibitory factor (MIF) at the tumor edge causing proliferative expansion of M2 macrophages, which in turn promotes tumor growth.
Thu Jun 29 00:00:00 EDT 2017
Lack of interleukin-6 in the tumor microenvironment augments type-1 immunity and increases the efficacy of cancer immunotherapy.
Cancer science
Ohno Y,Toyoshima Y,Yurino H,Monma N,Xiang H,Sumida K,Kaneumi S,Terada S,Hashimoto S,Ikeo K,Homma S,Kawamura H,Takahashi N,Taketomi A,Kitamura H
Sun Oct 01 00:00:00 EDT 2017
The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression.
Journal of immunology (Baltimore, Md. : 1950)
Ghosh S,Wallerath C,Covarrubias S,Hornung V,Carpenter S,Fitzgerald KA
Wed Nov 01 00:00:00 EDT 2017
Regulatory T Cells Promote Myositis and Muscle Damage in Toxoplasma gondii Infection.
Journal of immunology (Baltimore, Md. : 1950)
Jin RM,Blair SJ,Warunek J,Heffner RR,Blader IJ,Wohlfert EA
Sun Jan 01 00:00:00 EST 2017
SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions.
Journal of immunology (Baltimore, Md. : 1950)
Takahashi R,Nakatsukasa H,Shiozawa S,Yoshimura A
Sat Jul 01 00:00:00 EDT 2017
STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection.
Journal of immunology (Baltimore, Md. : 1950)
Stier MT,Goleniewska K,Cephus JY,Newcomb DC,Sherrill TP,Boyd KL,Bloodworth MH,Moore ML,Chen K,Kolls JK,Peebles RS
Sat Jul 15 00:00:00 EDT 2017
AhR-deficiency as a cause of demyelinating disease and inflammation.
Scientific reports
Juricek L,Carcaud J,Pelhaitre A,Riday TT,Chevallier A,Lanzini J,Auzeil N,Laprévote O,Dumont F,Jacques S,Letourneur F,Massaad C,Agulhon C,Barouki R,Beraneck M,Coumoul X
Tue Aug 29 00:00:00 EDT 2017
Low immunogenicity of mouse induced pluripotent stem cell-derived neural stem/progenitor cells.
Scientific reports
Itakura G,Ozaki M,Nagoshi N,Kawabata S,Nishiyama Y,Sugai K,Iida T,Kashiwagi R,Ookubo T,Yastake K,Matsubayashi K,Kohyama J,Iwanami A,Matsumoto M,Nakamura M,Okano H
Wed Oct 11 00:00:00 EDT 2017
PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity.
Cell reports
Gato-Cañas M,Zuazo M,Arasanz H,Ibañez-Vea M,Lorenzo L,Fernandez-Hinojal G,Vera R,Smerdou C,Martisova E,Arozarena I,Wellbrock C,Llopiz D,Ruiz M,Sarobe P,Breckpot K,Kochan G,Escors D
Tue Aug 22 00:00:00 EDT 2017
Skin infections are eliminated by cooperation of the fibrinolytic and innate immune systems.
Science immunology
Santus W,Barresi S,Mingozzi F,Broggi A,Orlandi I,Stamerra G,Vai M,Martorana AM,Polissi A,Köhler JR,Liu N,Zanoni I,Granucci F
315-05 was used in In vivo experiments to determine the role of NFAT in innate immune responses compared to adaptive, and downstream signaling mecchanisms.
Fri Sep 22 00:00:00 EDT 2017
Tolerogenic dendritic cells are efficiently generated using minocycline and dexamethasone.
Scientific reports
Lee JH,Park CS,Jang S,Kim JW,Kim SH,Song S,Kim K,Lee CK
Wed Nov 08 00:00:00 EST 2017
CD36 receptor regulates malaria-induced immune responses primarily at early blood stage infection contributing to parasitemia control and resistance to mortality.
The Journal of biological chemistry
Thylur RP,Wu X,Gowda NM,Punnath K,Neelgund SE,Febbraio M,Gowda DC
Fri Jun 02 00:00:00 EDT 2017
Annexin-A1 enhances breast cancer growth and migration by promoting alternative macrophage polarization in the tumour microenvironment.
Scientific reports
Moraes LA,Kar S,Foo SL,Gu T,Toh YQ,Ampomah PB,Sachaphibulkij K,Yap G,Zharkova O,Lukman HM,Fairhurst AM,Kumar AP,Lim LHK
Wed Dec 20 00:00:00 EST 2017
A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information.
Nature communications
Luo Y,Zhao X,Zhou J,Yang J,Zhang Y,Kuang W,Peng J,Chen L,Zeng J
Mon Sep 18 00:00:00 EDT 2017
Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria.
Nature communications
Rivera-Correa J,Guthmiller JJ,Vijay R,Fernandez-Arias C,Pardo-Ruge MA,Gonzalez S,Butler NS,Rodriguez A
Fri Nov 03 00:00:00 EDT 2017
p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis.
Nature communications
Okuma A,Hanyu A,Watanabe S,Hara E
Tue Dec 12 00:00:00 EST 2017
Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells.
Scientific reports
Wu H,Weidinger C,Schmidt F,Keye J,Friedrich M,Yerinde C,Willimsky G,Qin Z,Siegmund B,Glauben R
Tue Aug 08 00:00:00 EDT 2017
HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice.
Scientific reports
Leus NG,van den Bosch T,van der Wouden PE,Krist K,Ourailidou ME,Eleftheriadis N,Kistemaker LE,Bos S,Gjaltema RA,Mekonnen SA,Bischoff R,Gosens R,Haisma HJ,Dekker FJ
315-05 was used in In vitro experiments to highlight for the first time the potential of isoform-selective HDACi for the treatment of inflammatory lung disease like chronic obstructive pulmonary disease.
Mon Mar 27 00:00:00 EDT 2017
A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices.
Pulmonary pharmacology & therapeutics
van den Bosch T,Leus NGJ,Wapenaar H,Boichenko A,Hermans J,Bischoff R,Haisma HJ,Dekker FJ
315-05 was used in Tissue/organ to propose that 6-alkylsalicylates such as MG149 have potential for development towards applications in the treatment of inflammatory lung diseases.
Thu Jun 01 00:00:00 EDT 2017
Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms.
Nature communications
Kim DS,Dastidar H,Zhang C,Zemp FJ,Lau K,Ernst M,Rakic A,Sikdar S,Rajwani J,Naumenko V,Balce DR,Ewanchuk BW,Tailor P,Yates RM,Jenne C,Gafuik C,Mahoney DJ
Thu Aug 24 00:00:00 EDT 2017
M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes.
Scientific reports
Bai L,Liu X,Zheng Q,Kong M,Zhang X,Hu R,Lou J,Ren F,Chen Y,Zheng S,Liu S,Han YP,Duan Z,Pandol SJ
Tue Sep 05 00:00:00 EDT 2017
Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.
The Journal of biological chemistry
Hayakawa M,Hayakawa H,Petrova T,Ritprajak P,Sutavani RV,Jiménez-Andrade GY,Sano Y,Choo MK,Seavitt J,Venigalla RKC,Otsu K,Georgopoulos K,Arthur JSC,Park JM
Fri Feb 03 00:00:00 EST 2017
Glucuronides of phytoestrogen flavonoid enhance macrophage function via conversion to aglycones by β-glucuronidase in macrophages.
Immunity, inflammation and disease
Kaneko A,Matsumoto T,Matsubara Y,Sekiguchi K,Koseki J,Yakabe R,Aoki K,Aiba S,Yamasaki K
Fri Sep 01 00:00:00 EDT 2017
Hemojuvelin regulates the innate immune response to peritoneal bacterial infection in mice.
Cell discovery
Wu Q,Shen Y,Tao Y,Wei J,Wang H,An P,Zhang Z,Gao H,Zhou T,Wang F,Min J
Wed Sep 30 00:00:00 EDT 2020
Sophorolipid Butyl Ester Diacetate Does Not Affect Macrophage Polarization but Enhances Astrocytic Glial Fibrillary Acidic Protein Expression at Micromolar Concentrations in Vitro.
ACS chemical neuroscience
Ziemba AM,Gottipati MK,Totsingan F,Hanes CM,Gross RA,Lennartz MR,Gilbert RJ
315-05 was used in Cell Culture to study the response of peritoneal macrophages (PMACs) and spinal cord astrocytes to soluble sophorolipid butyl ester diacetate (SLBEDA) in vitro.
Wed Apr 19 00:00:00 EDT 2017
IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.
Cell
Man SM,Karki R,Sasai M,Place DE,Kesavardhana S,Temirov J,Frase S,Zhu Q,Malireddi RKS,Kuriakose T,Peters JL,Neale G,Brown SA,Yamamoto M,Kanneganti TD
Thu Oct 06 00:00:00 EDT 2016
DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.
Cell
Herrtwich L,Nanda I,Evangelou K,Nikolova T,Horn V,Erny D,Stefanowski J,Rogell L,Klein C,Gharun K,Follo M,Seidl M,Kremer B,Münke N,Senges J,Fliegauf M,Aschman T,Pfeifer D,Sarrazin S,Sieweke MH,Wagner D,Dierks C,Haaf T,Ness T,Zaiss MM,Voll RE,Deshmukh SD,Prinz M,Goldmann T,Hölscher C,Hauser AE,Lopez-Contreras AJ,Grün D,Gorgoulis V,Diefenbach A,Henneke P,Triantafyllopoulou A
Thu Nov 17 00:00:00 EST 2016
Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade.
Cell
Benci JL,Xu B,Qiu Y,Wu TJ,Dada H,Twyman-Saint Victor C,Cucolo L,Lee DSM,Pauken KE,Huang AC,Gangadhar TC,Amaravadi RK,Schuchter LM,Feldman MD,Ishwaran H,Vonderheide RH,Maity A,Wherry EJ,Minn AJ
Thu Dec 01 00:00:00 EST 2016
The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses.
Immunity
Chou C,Verbaro DJ,Tonc E,Holmgren M,Cella M,Colonna M,Bhattacharya D,Egawa T
Tue Sep 20 00:00:00 EDT 2016
Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.
Immunity
Bhattacharya N,Yuan R,Prestwood TR,Penny HL,DiMaio MA,Reticker-Flynn NE,Krois CR,Kenkel JA,Pham TD,Carmi Y,Tolentino L,Choi O,Hulett R,Wang J,Winer DA,Napoli JL,Engleman EG
Tue Sep 20 00:00:00 EDT 2016
Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination.
The Journal of experimental medicine
Thomas-Claudepierre AS,Robert I,Rocha PP,Raviram R,Schiavo E,Heyer V,Bonneau R,Luo VM,Reddy JK,Borggrefe T,Skok JA,Reina-San-Martin B
Mon Mar 07 00:00:00 EST 2016
Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent.
Proceedings of the National Academy of Sciences of the United States of America
Liu L,Lu Y,Martinez J,Bi Y,Lian G,Wang T,Milasta S,Wang J,Yang M,Liu G,Green DR,Wang R
Tue Feb 09 00:00:00 EST 2016
Durable antitumor responses to CD47 blockade require adaptive immune stimulation.
Proceedings of the National Academy of Sciences of the United States of America
Sockolosky JT,Dougan M,Ingram JR,Ho CC,Kauke MJ,Almo SC,Ploegh HL,Garcia KC
Tue May 10 00:00:00 EDT 2016
miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα.
Molecular therapy. Nucleic acids
Bi J,Zeng X,Zhao L,Wei Q,Yu L,Wang X,Yu Z,Cao Y,Shan F,Wei M
Tue Sep 27 00:00:00 EDT 2016
miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα.
Molecular therapy. Nucleic acids
Bi J,Zeng X,Zhao L,Wei Q,Yu L,Wang X,Yu Z,Cao Y,Shan F,Wei M
Tue Sep 27 00:00:00 EDT 2016
Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties.
European journal of medicinal chemistry
Eleftheriadis N,Poelman H,Leus NGJ,Honrath B,Neochoritis CG,Dolga A,Dömling A,Dekker FJ
315-05 was used in Cell Culture to study the development of novel 15-LOX-1 inhibitors for further investigation of 15-LOX-1 applications in the central nervous system (CNS).
Fri Oct 21 00:00:00 EDT 2016
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases.
Biochemical pharmacology
van den Bosch T,Boichenko A,Leus NGJ,Ourailidou ME,Wapenaar H,Rotili D,Mai A,Imhof A,Bischoff R,Haisma HJ,Dekker FJ
315-05 was used in Cell Culture to indicate that histone acetyltransferase p300 inhibitor C646 has potential for further development towards applications in the treatment of inflammation.
Mon Feb 15 00:00:00 EST 2016
HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity.
Biochemical pharmacology
Leus NG,van der Wouden PE,van den Bosch T,Hooghiemstra WTR,Ourailidou ME,Kistemaker LE,Bischoff R,Gosens R,Haisma HJ,Dekker FJ
315-05 was used in Sample Preparation (Western Blotting) to indicate that pharmacological HDAC 3-selective inhibition by inhibitors such as RGFP966 may provide a novel and effective approach toward development of therapeutics for inflammatory lung diseases.
Sun May 15 00:00:00 EDT 2016
CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata.
Journal of immunology (Baltimore, Md. : 1950)
Dai Z,Xing L,Cerise J,Wang EH,Jabbari A,de Jong A,Petukhova L,Christiano AM,Clynes R
Mon Aug 15 00:00:00 EDT 2016
Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection.
Journal of immunology (Baltimore, Md. : 1950)
Marinho FV,Fahel JS,Scanga CA,Gomes MT,Guimarães G,Carvalho GR,Morales SV,Báfica A,Oliveira SC
Thu Sep 01 00:00:00 EDT 2016
Novel Insights into the Multiple Sclerosis Risk Gene ANKRD55.
Journal of immunology (Baltimore, Md. : 1950)
Lopez de Lapuente A,Feliú A,Ugidos N,Mecha M,Mena J,Astobiza I,Riera J,Carrillo-Salinas FJ,Comabella M,Montalban X,Alloza I,Guaza C,Vandenbroeck K
Wed Jun 01 00:00:00 EDT 2016
Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis.
Journal of immunology (Baltimore, Md. : 1950)
Haribhai D,Ziegelbauer J,Jia S,Upchurch K,Yan K,Schmitt EG,Salzman NH,Simpson P,Hessner MJ,Chatila TA,Williams CB
Fri Apr 15 00:00:00 EDT 2016
IL-17 Augments B Cell Activation in Ocular Surface Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Subbarayal B,Chauhan SK,Di Zazzo A,Dana R
Tue Nov 01 00:00:00 EDT 2016
Tolerogenic Phenotype of IFN-γ-Induced IDO+ Dendritic Cells Is Maintained via an Autocrine IDO-Kynurenine/AhR-IDO Loop.
Journal of immunology (Baltimore, Md. : 1950)
Li Q,Harden JL,Anderson CD,Egilmez NK
Mon Aug 01 00:00:00 EDT 2016
The Repair of Skeletal Muscle Requires Iron Recycling through Macrophage Ferroportin.
Journal of immunology (Baltimore, Md. : 1950)
Corna G,Caserta I,Monno A,Apostoli P,Manfredi AA,Camaschella C,Rovere-Querini P
Thu Sep 01 00:00:00 EDT 2016
Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration.
Journal of immunology (Baltimore, Md. : 1950)
Lo TH,Silveira PA,Fromm PD,Verma ND,Vu PA,Kupresanin F,Adam R,Kato M,Cogger VC,Clark GJ,Hart DN
Mon Aug 01 00:00:00 EDT 2016
Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice.
Journal of immunology (Baltimore, Md. : 1950)
Niu S,Bian Z,Tremblay A,Luo Y,Kidder K,Mansour A,Zen K,Liu Y
Sat Oct 15 00:00:00 EDT 2016
Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt Signaling Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Sertorio M,Amarachintha S,Wilson A,Pang Q
Fri Apr 01 00:00:00 EDT 2016
IDO2 Modulates T Cell-Dependent Autoimmune Responses through a B Cell-Intrinsic Mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Merlo LM,DuHadaway JB,Grabler S,Prendergast GC,Muller AJ,Mandik-Nayak L
Wed Jun 01 00:00:00 EDT 2016
β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage.
Journal of immunology (Baltimore, Md. : 1950)
Boucard-Jourdin M,Kugler D,Endale Ahanda ML,This S,De Calisto J,Zhang A,Mora JR,Stuart LM,Savill J,Lacy-Hulbert A,Paidassi H
Thu Sep 01 00:00:00 EDT 2016
Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950)
Matsumura K,Iwai H,Kato-Miyazawa M,Kirikae F,Zhao J,Yanagawa T,Ishii T,Miyoshi-Akiyama T,Funatogawa K,Kirikae T
Sat Oct 15 00:00:00 EDT 2016
Bone-protective Functions of Netrin 1 Protein.
The Journal of biological chemistry
Maruyama K,Kawasaki T,Hamaguchi M,Hashimoto M,Furu M,Ito H,Fujii T,Takemura N,Karuppuchamy T,Kondo T,Kawasaki T,Fukasaka M,Misawa T,Saitoh T,Suzuki Y,Martino MM,Kumagai Y,Akira S
Fri Nov 11 00:00:00 EST 2016
The Balance between Conventional DCs and Plasmacytoid DCs Is Pivotal for Immunological Tolerance during Pregnancy in the Mouse.
Scientific reports
Fang WN,Shi M,Meng CY,Li DD,Peng JP
Fri May 27 00:00:00 EDT 2016
Monocytic MKP-1 is a Sensor of the Metabolic Environment and Regulates Function and Phenotypic Fate of Monocyte-Derived Macrophages in Atherosclerosis.
Scientific reports
Kim HS,Tavakoli S,Piefer LA,Nguyen HN,Asmis R
Tue Sep 27 00:00:00 EDT 2016
The association between laminin and microglial morphology in vitro.
Scientific reports
Tam WY,Au NP,Ma CH
Thu Jun 23 00:00:00 EDT 2016
Fine-tuning of macrophage activation using synthetic rocaglate derivatives.
Scientific reports
Bhattacharya B,Chatterjee S,Devine WG,Kobzik L,Beeler AB,Porco JA,Kramnik I
Mon Apr 18 00:00:00 EDT 2016
Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.
The Journal of biological chemistry
Murase R,Sato H,Yamamoto K,Ushida A,Nishito Y,Ikeda K,Kobayashi T,Yamamoto T,Taketomi Y,Murakami M
Fri Mar 25 00:00:00 EDT 2016
Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy.
Scientific reports
Zhou M,Zhang X,Wen X,Wu T,Wang W,Yang M,Wang J,Fang M,Lin B,Lin H
Thu Aug 25 00:00:00 EDT 2016
Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.
Nature communications
Saintamand A,Vincent-Fabert C,Garot A,Rouaud P,Oruc Z,Magnone V,Cogné M,Denizot Y
Wed Feb 17 00:00:00 EST 2016
Pancreatic Cancer Cell Exosome-Mediated Macrophage Reprogramming and the Role of MicroRNAs 155 and 125b2 Transfection using Nanoparticle Delivery Systems.
Scientific reports
Su MJ,Aldawsari H,Amiji M
Fri Jul 22 00:00:00 EDT 2016
Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages.
Scientific reports
Huber R,Meier B,Otsuka A,Fenini G,Satoh T,Gehrke S,Widmer D,Levesque MP,Mangana J,Kerl K,Gebhardt C,Fujii H,Nakashima C,Nonomura Y,Kabashima K,Dummer R,Contassot E,French LE
Mon Jul 18 00:00:00 EDT 2016
Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages.
The Journal of biological chemistry
Yao Y,Shi Q,Chen B,Wang Q,Li X,Li L,Huang Y,Ji J,Shen P
Fri Aug 12 00:00:00 EDT 2016
Huaier extract suppresses breast cancer via regulating tumor-associated macrophages.
Scientific reports
Li Y,Qi W,Song X,Lv S,Zhang H,Yang Q
Mon Feb 01 00:00:00 EST 2016
Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport.
Scientific reports
Song S,Faleo G,Yeung R,Kant R,Posselt AM,Desai TA,Tang Q,Roy S
Thu Mar 24 00:00:00 EDT 2016
Liposomal prednisolone inhibits vascular inflammation and enhances venous outward remodeling in a murine arteriovenous fistula model.
Scientific reports
Wong C,Bezhaeva T,Rothuizen TC,Metselaar JM,de Vries MR,Verbeek FP,Vahrmeijer AL,Wezel A,van Zonneveld AJ,Rabelink TJ,Quax PH,Rotmans JI
Wed Jul 27 00:00:00 EDT 2016
Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells.
Scientific reports
Sonoda S,Yamaza H,Ma L,Tanaka Y,Tomoda E,Aijima R,Nonaka K,Kukita T,Shi S,Nishimura F,Yamaza T
Mon Jan 18 00:00:00 EST 2016
MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways.
Scientific reports
Moore CE,Pickford J,Cagampang FR,Stead RL,Tian S,Zhao X,Tang X,Byrne CD,Proud CG
Mon Apr 18 00:00:00 EDT 2016
Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung.
Frontiers in immunology
Zimmer J,Weitnauer M,Boutin S,Küblbeck G,Thiele S,Walker P,Lasitschka F,Lunding L,Orinska Z,Vock C,Arnold B,Wegmann M,Dalpke A
315-05 was used in Cell Culture to study the importance of nuclear translocation of SOCS1 which contains a nuclear localization sequence (NLS) to show that nuclear SOCS1 is a regulator of local immunity in the lung and unravel a so far unrecognized function for SOCS1 in the cell nucleus.
Wed Nov 20 00:00:00 EST 2019
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.
Nature
Twyman-Saint Victor C,Rech AJ,Maity A,Rengan R,Pauken KE,Stelekati E,Benci JL,Xu B,Dada H,Odorizzi PM,Herati RS,Mansfield KD,Patsch D,Amaravadi RK,Schuchter LM,Ishwaran H,Mick R,Pryma DA,Xu X,Feldman MD,Gangadhar TC,Hahn SM,Wherry EJ,Vonderheide RH,Minn AJ
Thu Apr 16 00:00:00 EDT 2015
Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.
Nature
Carmi Y,Spitzer MH,Linde IL,Burt BM,Prestwood TR,Perlman N,Davidson MG,Kenkel JA,Segal E,Pusapati GV,Bhattacharya N,Engleman EG
Thu May 07 00:00:00 EDT 2015
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.
Nature immunology
Schliehe C,Flynn EK,Vilagos B,Richson U,Swaminanthan S,Bosnjak B,Bauer L,Kandasamy RK,Griesshammer IM,Kosack L,Schmitz F,Litvak V,Sissons J,Lercher A,Bhattacharya A,Khamina K,Trivett AL,Tessarollo L,Mesteri I,Hladik A,Merkler D,Kubicek S,Knapp S,Epstein MM,Symer DE,Aderem A,Bergthaler A
315-05 was used in Cell Culture to investigate the role of Setdb2 in regulation of immune responses during bacterial infection.
Thu Jan 01 00:00:00 EST 2015
Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles.
The Journal of clinical investigation
Rothmeier AS,Marchese P,Petrich BG,Furlan-Freguia C,Ginsberg MH,Ruggeri ZM,Ruf W
Wed Apr 01 00:00:00 EDT 2015
Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
The Journal of clinical investigation
Leoni G,Neumann PA,Kamaly N,Quiros M,Nishio H,Jones HR,Sumagin R,Hilgarth RS,Alam A,Fredman G,Argyris I,Rijcken E,Kusters D,Reutelingsperger C,Perretti M,Parkos CA,Farokhzad OC,Neish AS,Nusrat A
Mon Mar 02 00:00:00 EST 2015
Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling.
The Journal of experimental medicine
Bourdonnay E,Zasłona Z,Penke LR,Speth JM,Schneider DJ,Przybranowski S,Swanson JA,Mancuso P,Freeman CM,Curtis JL,Peters-Golden M
Mon May 04 00:00:00 EDT 2015
V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation.
Autophagy
Florey O,Gammoh N,Kim SE,Jiang X,Overholtzer M
315-05 was used in Sample Preparation to demonstrate that the noncanonical activity of autophagy proteins which targets lipidation of microtubule-associated protein 1 light chain 3 (LC3) requires activity of the vacuolar-type H(+)-ATPase (V-ATPase) and is induced by osmotic imbalances within endolysosomal compartments.
Mon Nov 16 00:00:00 EST 2015
Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome.
Proceedings of the National Academy of Sciences of the United States of America
Watschinger K,Keller MA,McNeill E,Alam MT,Lai S,Sailer S,Rauch V,Patel J,Hermetter A,Golderer G,Geley S,Werner-Felmayer G,Plumb RS,Astarita G,Ralser M,Channon KM,Werner ER
Tue Feb 24 00:00:00 EST 2015
Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1.
Proceedings of the National Academy of Sciences of the United States of America
Li X,Wang D,Chen Z,Lu E,Wang Z,Duan J,Tian W,Wang Y,You L,Zou Y,Cheng Y,Zhu Q,Wan X,Xi T,Jiang M,Han Y,Cao C,Birnbaumer L,Chu WM,Yang Y
Tue Apr 14 00:00:00 EDT 2015
RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.
Proceedings of the National Academy of Sciences of the United States of America
Ohshima J,Sasai M,Liu J,Yamashita K,Ma JS,Lee Y,Bando H,Howard JC,Ebisu S,Hayashi M,Takeda K,Standley DM,Frickel EM,Yamamoto M
Tue Aug 18 00:00:00 EDT 2015
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Proceedings of the National Academy of Sciences of the United States of America
Liu J,Yuan Y,Chen W,Putra J,Suriawinata AA,Schenk AD,Miller HE,Guleria I,Barth RJ,Huang YH,Wang L
Tue May 26 00:00:00 EDT 2015
CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer.
Proceedings of the National Academy of Sciences of the United States of America
Cheah MT,Chen JY,Sahoo D,Contreras-Trujillo H,Volkmer AK,Scheeren FA,Volkmer JP,Weissman IL
Tue Apr 14 00:00:00 EDT 2015
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.
Journal of medicinal chemistry
Eleftheriadis N,Neochoritis CG,Leus NG,van der Wouden PE,Dömling A,Dekker FJ
315-05 was used in In vitro experiments to demonstrate a significant increase of interleukin-10 (IL-10) gene expression, which indicates its anti-inflammatory properties.
Thu Oct 08 00:00:00 EDT 2015
Pretreatment of Mesenchymal Stem Cells Manipulates Their Vasculoprotective Potential While Not Altering Their Homing Within the Injured Gut.
Stem cells (Dayton, Ohio)
Kavanagh DP,Suresh S,Newsome PN,Frampton J,Kalia N
Tue Sep 01 00:00:00 EDT 2015
The orphan nuclear receptor NR4A1 specifies a distinct subpopulation of quiescent myeloid-biased long-term HSCs.
Stem cells (Dayton, Ohio)
Land RH,Rayne AK,Vanderbeck AN,Barlowe TS,Manjunath S,Gross M,Eiger S,Klein PS,Cunningham NR,Huang J,Emerson SG,Punt JA
Thu Jan 01 00:00:00 EST 2015
Cryptococcus neoformans-induced macrophage lysosome damage crucially contributes to fungal virulence.
Journal of immunology (Baltimore, Md. : 1950)
Davis MJ,Eastman AJ,Qiu Y,Gregorka B,Kozel TR,Osterholzer JJ,Curtis JL,Swanson JA,Olszewski MA
Sun Mar 01 00:00:00 EST 2015
Regulatory Rebound in IL-12-Treated Tumors Is Driven by Uncommitted Peripheral Regulatory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Li Q,Virtuoso LP,Anderson CD,Egilmez NK
Sat Aug 01 00:00:00 EDT 2015
ATF3 Is a Key Regulator of Macrophage IFN Responses.
Journal of immunology (Baltimore, Md. : 1950)
Labzin LI,Schmidt SV,Masters SL,Beyer M,Krebs W,Klee K,Stahl R,Lütjohann D,Schultze JL,Latz E,De Nardo D
Sun Nov 01 00:00:00 EDT 2015
4-1BB ligand signaling to T cells limits T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Eun SY,Lee SW,Xu Y,Croft M
Thu Jan 01 00:00:00 EST 2015
Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Bardina SV,Michlmayr D,Hoffman KW,Obara CJ,Sum J,Charo IF,Lu W,Pletnev AG,Lim JK
Sun Nov 01 00:00:00 EDT 2015
Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Cimen Bozkus C,Elzey BD,Crist SA,Ellies LG,Ratliff TL
Tue Dec 01 00:00:00 EST 2015
DCIR maintains bone homeostasis by regulating IFN-γ production in T cells.
Journal of immunology (Baltimore, Md. : 1950)
Maruhashi T,Kaifu T,Yabe R,Seno A,Chung SH,Fujikado N,Iwakura Y
Mon Jun 15 00:00:00 EDT 2015
Cisplatin-induced apoptosis in auditory, renal, and neuronal cells is associated with nitration and downregulation of LMO4.
Cell death discovery
Rathinam R,Ghosh S,Neumann WL,Jamesdaniel S
315-05 was used in Cell Culture to investigate how the transcriptional regulator LMO4 facilitates the cytotoxic effects of cisplatin in auditory, renal, and neuronal cells.
Tue Sep 29 00:00:00 EDT 2020
Preparation of a cyanine-based fluorescent probe for highly selective detection of glutathione and its use in living cells and tissues of mice.
Nature protocols
Yin J,Kwon Y,Kim D,Lee D,Kim G,Hu Y,Ryu JH,Yoon J
315-05 was used in In vitro experiments to describe the preparation of CPDSA, a cyanine-based near-infrared (NIR) fluorescent probe for the detection of GSH in cells and in vivo.
Sun Nov 01 00:00:00 EDT 2015
Preparation of a cyanine-based fluorescent probe for highly selective detection of glutathione and its use in living cells and tissues of mice.
Nature protocols
Yin J,Kwon Y,Kim D,Lee D,Kim G,Hu Y,Ryu JH,Yoon J
315-05 was used in In vitro experiments to describe the preparation of CPDSA, a cyanine-based near-infrared (NIR) fluorescent probe for the detection of GSH in cells and in vivo.
Sun Nov 01 00:00:00 EDT 2015
Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension.
The Journal of biological chemistry
Prewitt AR,Ghose S,Frump AL,Datta A,Austin ED,Kenworthy AK,de Caestecker MP
Fri Jan 09 00:00:00 EST 2015
Tissue-type plasminogen activator (tPA) promotes M1 macrophage survival through p90 ribosomal S6 kinase (RSK) and p38 mitogen-activated protein kinase (MAPK) pathway.
The Journal of biological chemistry
Lin L,Jin Y,Hu K
Fri Mar 20 00:00:00 EDT 2015
Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin.
Cell death & disease
Tan HY,Wang N,Man K,Tsao SW,Che CM,Feng Y
Thu Oct 22 00:00:00 EDT 2015
Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells.
Nature communications
Sasaki K,Takada K,Ohte Y,Kondo H,Sorimachi H,Tanaka K,Takahama Y,Murata S
Tue Jun 23 00:00:00 EDT 2015
SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell.
The Journal of biological chemistry
Fujimaki K,Ogihara T,Morris DL,Oda H,Iida H,Fujitani Y,Mirmira RG,Evans-Molina C,Watada H
Fri Jul 03 00:00:00 EDT 2015
Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.
Nature communications
Graham DB,Becker CE,Doan A,Goel G,Villablanca EJ,Knights D,Mok A,Ng ACY,Doench JG,Root DE,Clish CB,Xavier RJ
Tue Jul 21 00:00:00 EDT 2015
Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes.
Scientific reports
Yamamoto S,Niida S,Azuma E,Yanagibashi T,Muramatsu M,Huang TT,Sagara H,Higaki S,Ikutani M,Nagai Y,Takatsu K,Miyazaki K,Hamashima T,Mori H,Matsuda N,Ishii Y,Sasahara M
Tue Feb 17 00:00:00 EST 2015
Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations.
Scientific reports
Lesterhuis WJ,Rinaldi C,Jones A,Rozali EN,Dick IM,Khong A,Boon L,Robinson BW,Nowak AK,Bosco A,Lake RA
Tue Jul 21 00:00:00 EDT 2015
RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling.
Nature communications
Patel J,McNeill E,Douglas G,Hale AB,de Bono J,Lee R,Iqbal AJ,Regan-Komito D,Stylianou E,Greaves DR,Channon KM
Wed Mar 18 00:00:00 EDT 2015
Tumour-promoting role of SOCS1 in colorectal cancer cells.
Scientific reports
Tobelaim WS,Beaurivage C,Champagne A,Pomerleau V,Simoneau A,Chababi W,Yeganeh M,Thibault P,Klinck R,Carrier JC,Ferbeyre G,Ilangumaran S,Saucier C
Tue Sep 22 00:00:00 EDT 2015
Natural Killer Cells-Produced IFN-γ Improves Bone Marrow-Derived Hepatocytes Regeneration in Murine Liver Failure Model.
Scientific reports
Li L,Zeng Z,Qi Z,Wang X,Gao X,Wei H,Sun R,Tian Z
Tue Sep 08 00:00:00 EDT 2015
The TLR2 is activated by sporozoites and suppresses intrahepatic rodent malaria parasite development.
Scientific reports
Zheng H,Tan Z,Zhou T,Zhu F,Ding Y,Liu T,Wu Y,Xu W
Tue Dec 15 00:00:00 EST 2015
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.
Cell
Dillon CP,Weinlich R,Rodriguez DA,Cripps JG,Quarato G,Gurung P,Verbist KC,Brewer TL,Llambi F,Gong YN,Janke LJ,Kelliher MA,Kanneganti TD,Green DR
Thu May 22 00:00:00 EDT 2014
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.
Immunity
Shouval DS,Biswas A,Goettel JA,McCann K,Conaway E,Redhu NS,Mascanfroni ID,Al Adham Z,Lavoie S,Ibourk M,Nguyen DD,Samsom JN,Escher JC,Somech R,Weiss B,Beier R,Conklin LS,Ebens CL,Santos FG,Ferreira AR,Sherlock M,Bhan AK,Müller W,Mora JR,Quintana FJ,Klein C,Muise AM,Horwitz BH,Snapper SB
Thu May 15 00:00:00 EDT 2014
A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.
Blood
Steward-Tharp SM,Laurence A,Kanno Y,Kotlyar A,Villarino AV,Sciume G,Kuchen S,Resch W,Wohlfert EA,Jiang K,Hirahara K,Vahedi G,Sun HW,Feigenbaum L,Milner JD,Holland SM,Casellas R,Powrie F,O'Shea JJ
Thu May 08 00:00:00 EDT 2014
Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection.
The Journal of experimental medicine
Stock AT,Smith JM,Carbone FR
Mon May 05 00:00:00 EDT 2014
Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease.
EMBO molecular medicine
Bilbao D,Luciani L,Johannesson B,Piszczek A,Rosenthal N
Sat Nov 01 00:00:00 EDT 2014
Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth.
Proceedings of the National Academy of Sciences of the United States of America
Wang D,Fu L,Ning W,Guo L,Sun X,Dey SK,Chaturvedi R,Wilson KT,DuBois RN
Tue May 13 00:00:00 EDT 2014
IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.
Proceedings of the National Academy of Sciences of the United States of America
Ben-Addi A,Mambole-Dema A,Brender C,Martin SR,Janzen J,Kjaer S,Smerdon SJ,Ley SC
Tue Jun 10 00:00:00 EDT 2014
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.
Proceedings of the National Academy of Sciences of the United States of America
Gobbetti T,Coldewey SM,Chen J,McArthur S,le Faouder P,Cenac N,Flower RJ,Thiemermann C,Perretti M
Tue Dec 30 00:00:00 EST 2014
Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction.
Proceedings of the National Academy of Sciences of the United States of America
Brennan PJ,Tatituri RV,Heiss C,Watts GF,Hsu FF,Veerapen N,Cox LR,Azadi P,Besra GS,Brenner MB
Tue Sep 16 00:00:00 EDT 2014
Avirulent strains of Toxoplasma gondii infect macrophages by active invasion from the phagosome.
Proceedings of the National Academy of Sciences of the United States of America
Zhao Y,Marple AH,Ferguson DJ,Bzik DJ,Yap GS
Tue Apr 29 00:00:00 EDT 2014
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Le Mercier I,Putra J,Chen W,Liu J,Schenk AD,Nowak EC,Suriawinata AA,Li J,Noelle RJ
Tue Oct 14 00:00:00 EDT 2014
Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease.
Cell death and differentiation
Tang Y,Li T,Li J,Yang J,Liu H,Zhang XJ,Le W
Sat Mar 01 00:00:00 EST 2014
1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice.
Journal of immunology (Baltimore, Md. : 1950)
Ferreira GB,Gysemans CA,Demengeot J,da Cunha JP,Vanherwegen AS,Overbergh L,Van Belle TL,Pauwels F,Verstuyf A,Korf H,Mathieu C
Thu May 01 00:00:00 EDT 2014
Role of Th1/Th17 balance regulated by T-bet in a mouse model of Mycobacterium avium complex disease.
Journal of immunology (Baltimore, Md. : 1950)
Matsuyama M,Ishii Y,Yageta Y,Ohtsuka S,Ano S,Matsuno Y,Morishima Y,Yoh K,Takahashi S,Ogawa K,Hogaboam CM,Hizawa N
Sat Feb 15 00:00:00 EST 2014
Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-γ-producing T cells.
Journal of immunology (Baltimore, Md. : 1950)
Mori T,Iwasaki Y,Seki Y,Iseki M,Katayama H,Yamamoto K,Takatsu K,Takaki S
Fri Aug 15 00:00:00 EDT 2014
Tick-borne flaviviruses antagonize both IRF-1 and type I IFN signaling to inhibit dendritic cell function.
Journal of immunology (Baltimore, Md. : 1950)
Robertson SJ,Lubick KJ,Freedman BA,Carmody AB,Best SM
Sat Mar 15 00:00:00 EDT 2014
TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Goto Y,Ogawa K,Nakamura TJ,Hattori A,Tsujimoto M
Thu May 01 00:00:00 EDT 2014
The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Hou Y,Lin H,Zhu L,Liu Z,Hu F,Shi J,Yang T,Shi X,Guo H,Tan X,Zhang L,Wang Q,Li Z,Zhao Y
Tue Jul 01 00:00:00 EDT 2014
The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Hou Y,Lin H,Zhu L,Liu Z,Hu F,Shi J,Yang T,Shi X,Guo H,Tan X,Zhang L,Wang Q,Li Z,Zhao Y
Tue Jul 01 00:00:00 EDT 2014
MAPK phosphotase 5 deficiency contributes to protection against blood-stage Plasmodium yoelii 17XL infection in mice.
Journal of immunology (Baltimore, Md. : 1950)
Cheng Q,Zhang Q,Xu X,Yin L,Sun L,Lin X,Dong C,Pan W
Tue Apr 15 00:00:00 EDT 2014
Zhankuic acid A isolated from Taiwanofungus camphoratus is a novel selective TLR4/MD-2 antagonist with anti-inflammatory properties.
Journal of immunology (Baltimore, Md. : 1950)
Chen YF,Shiau AL,Wang SH,Yang JS,Chang SJ,Wu CL,Wu TS
Sat Mar 15 00:00:00 EDT 2014
Differential control of Mincle-dependent cord factor recognition and macrophage responses by the transcription factors C/EBPβ and HIF1α.
Journal of immunology (Baltimore, Md. : 1950)
Schoenen H,Huber A,Sonda N,Zimmermann S,Jantsch J,Lepenies B,Bronte V,Lang R
Wed Oct 01 00:00:00 EDT 2014
Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production.
Journal of immunology (Baltimore, Md. : 1950)
Ma J,Becker C,Reyes C,Underhill DM
Sat Feb 15 00:00:00 EST 2014
NADPH oxidase modifies patterns of MHC class II-restricted epitopic repertoires through redox control of antigen processing.
Journal of immunology (Baltimore, Md. : 1950)
Allan ER,Tailor P,Balce DR,Pirzadeh P,McKenna NT,Renaux B,Warren AL,Jirik FR,Yates RM
Sun Jun 01 00:00:00 EDT 2014
Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis.
Journal of immunology (Baltimore, Md. : 1950)
Lu N,Wang L,Cao H,Liu L,Van Kaer L,Washington MK,Rosen MJ,Dubé PE,Wilson KT,Ren X,Hao X,Polk DB,Yan F
Sat Feb 01 00:00:00 EST 2014
Therapy of peritoneally disseminated colon cancer by TAP-deficient embryonic stem cell-derived macrophages in allogeneic recipients.
Journal of immunology (Baltimore, Md. : 1950)
Haga E,Endo Y,Haruta M,Koba C,Matsumura K,Takamatsu K,Ikeda T,Nishimura Y,Senju S
Fri Aug 15 00:00:00 EDT 2014
Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950)
Ohshima J,Lee Y,Sasai M,Saitoh T,Su Ma J,Kamiyama N,Matsuura Y,Pann-Ghill S,Hayashi M,Ebisu S,Takeda K,Akira S,Yamamoto M
Tue Apr 01 00:00:00 EDT 2014
High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP
315-05 was used in Sample Preparation (FC/FACS) to demonstrate that in murine pregnancy, a supraphysiological dose of IFN-γ could induce peri-implantation failure.
Thu May 01 00:00:00 EDT 2014
IFN-γ induces aberrant CD49b⁺ NK cell recruitment through regulating CX3CL1: a novel mechanism by which IFN-γ provokes pregnancy failure.
Cell death & disease
Li ZY,Chao HH,Liu HY,Song ZH,Li LL,Zhang YJ,Yang Y,Peng JP
Thu Nov 06 00:00:00 EST 2014
Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation.
Nature communications
Fu H,Kishore M,Gittens B,Wang G,Coe D,Komarowska I,Infante E,Ridley AJ,Cooper D,Perretti M,Marelli-Berg FM
Fri Mar 14 00:00:00 EDT 2014
Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation.
Nature communications
Fu H,Kishore M,Gittens B,Wang G,Coe D,Komarowska I,Infante E,Ridley AJ,Cooper D,Perretti M,Marelli-Berg FM
Fri Mar 14 00:00:00 EDT 2014
Myeloid suppressor cells require membrane TNFR2 expression for suppressive activity.
Immunity, inflammation and disease
Polz J,Remke A,Weber S,Schmidt D,Weber-Steffens D,Pietryga-Krieger A,Müller N,Ritter U,Mostböck S,Männel DN
Fri Aug 01 00:00:00 EDT 2014
Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice.
The Journal of biological chemistry
Ahn BJ,Le H,Shin MW,Bae SJ,Lee EJ,Wee HJ,Cha JH,Lee HJ,Lee HS,Kim JH,Kim CY,Seo JH,Lo EH,Jeon S,Lee MN,Oh GT,Yin GN,Ryu JK,Suh JK,Kim KW
Fri Feb 07 00:00:00 EST 2014
Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis.
Scientific reports
Li L,Wang L,Wu Z,Yao L,Wu Y,Huang L,Liu K,Zhou X,Gou D
Fri Aug 29 00:00:00 EDT 2014
The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/microglia-induced inflammation.
The Journal of biological chemistry
Eitas TK,Chou WC,Wen H,Gris D,Robbins GR,Brickey J,Oyama Y,Ting JP
Fri Feb 14 00:00:00 EST 2014
sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor.
Scientific reports
Pan Y,Wan J,Liu Y,Yang Q,Liang W,Singhal PC,Saleem MA,Ding G
Wed Oct 22 00:00:00 EDT 2014
Tumor necrosis factor and transforming growth factor β regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP).
The Journal of biological chemistry
Lopez M,Meier D,Müller A,Franken P,Fujita J,Fontana A
Fri Jan 31 00:00:00 EST 2014
A regenerative approach to the treatment of multiple sclerosis.
Nature
Deshmukh VA,Tardif V,Lyssiotis CA,Green CC,Kerman B,Kim HJ,Padmanabhan K,Swoboda JG,Ahmad I,Kondo T,Gage FH,Theofilopoulos AN,Lawson BR,Schultz PG,Lairson LL
Thu Oct 17 00:00:00 EDT 2013
Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins.
Cell
Nathan JA,Spinnenhirn V,Schmidtke G,Basler M,Groettrup M,Goldberg AL
Thu Feb 28 00:00:00 EST 2013
Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization.
Immunity
Spence S,Fitzsimons A,Boyd CR,Kessler J,Fitzgerald D,Elliott J,Gabhann JN,Smith S,Sica A,Hams E,Saunders SP,Jefferies CA,Fallon PG,McAuley DF,Kissenpfennig A,Johnston JA
Thu Jan 24 00:00:00 EST 2013
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Nature immunology
Satpathy AT,Briseño CG,Lee JS,Ng D,Manieri NA,Kc W,Wu X,Thomas SR,Lee WL,Turkoz M,McDonald KG,Meredith MM,Song C,Guidos CJ,Newberry RD,Ouyang W,Murphy TL,Stappenbeck TS,Gommerman JL,Nussenzweig MC,Colonna M,Kopan R,Murphy KM
315-05 was used in Sample Preparation to elucidate the cellular source of essential IL-23 production required for the mucosal response to attaching-and-effacing bacterial infection.
Sun Sep 01 00:00:00 EDT 2013
Interferon-γ impairs proliferation of hematopoietic stem cells in mice.
Blood
de Bruin AM,Demirel Ö,Hooibrink B,Brandts CH,Nolte MA
Thu May 02 00:00:00 EDT 2013
Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes.
The Journal of clinical investigation
Warszawska JM,Gawish R,Sharif O,Sigel S,Doninger B,Lakovits K,Mesteri I,Nairz M,Boon L,Spiel A,Fuhrmann V,Strobl B,Müller M,Schenk P,Weiss G,Knapp S
Thu Aug 01 00:00:00 EDT 2013
Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination.
The Journal of experimental medicine
Anderberg C,Cunha SI,Zhai Z,Cortez E,Pardali E,Johnson JR,Franco M,Páez-Ribes M,Cordiner R,Fuxe J,Johansson BR,Goumans MJ,Casanovas O,ten Dijke P,Arthur HM,Pietras K
Mon Mar 11 00:00:00 EDT 2013
Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin.
The Journal of experimental medicine
Curran MA,Geiger TL,Montalvo W,Kim M,Reiner SL,Al-Shamkhani A,Sun JC,Allison JP
Mon Apr 08 00:00:00 EDT 2013
Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury.
Proceedings of the National Academy of Sciences of the United States of America
Linkermann A,Bräsen JH,Darding M,Jin MK,Sanz AB,Heller JO,De Zen F,Weinlich R,Ortiz A,Walczak H,Weinberg JM,Green DR,Kunzendorf U,Krautwald S
Tue Jul 16 00:00:00 EDT 2013
A new tool to ensure the fluorescent dye labeling stability of nanocarriers: a real challenge for fluorescence imaging.
Journal of controlled release : official journal of the Controlled Release Society
Bastiat G,Pritz CO,Roider C,Fouchet F,Lignières E,Jesacher A,Glueckert R,Ritsch-Marte M,Schrott-Fischer A,Saulnier P,Benoit JP
315-05 was used in Cell Culture to show that DiO-loaded LNCs had to be internalized to observe fluorescence inside the cells, providing a further confirmation of the absence of transfer in this case, and the stability of fluorescence labeling of the LNCs.
Sat Sep 28 00:00:00 EDT 2013
Mesenchymal stem cells are mobilized from the bone marrow during inflammation.
Frontiers in immunology
Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE
Wed Mar 06 00:00:00 EST 2013
Trp53 deficiency protects against acute intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Spehlmann ME,Manthey CF,Dann SM,Hanson E,Sandhu SS,Liu LY,Abdelmalak FK,Diamanti MA,Retzlaff K,Scheller J,Rose-John S,Greten FR,Wang JY,Eckmann L
Mon Jul 15 00:00:00 EDT 2013
MARCO is required for TLR2- and Nod2-mediated responses to Streptococcus pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx.
Journal of immunology (Baltimore, Md. : 1950)
Dorrington MG,Roche AM,Chauvin SE,Tu Z,Mossman KL,Weiser JN,Bowdish DM
Tue Jan 01 00:00:00 EST 2013
Selective activation of antigen-experienced T cells by anti-CD3 constrained on nanoparticles.
Journal of immunology (Baltimore, Md. : 1950)
Lo YC,Edidin MA,Powell JD
Fri Nov 15 00:00:00 EST 2013
Thymic stromal lymphopoietin amplifies the differentiation of alternatively activated macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Han H,Headley MB,Xu W,Comeau MR,Zhou B,Ziegler SF
Fri Feb 01 00:00:00 EST 2013
The key role of IL-6-arginase cascade for inducing dendritic cell-dependent CD4(+) T cell dysfunction in tumor-bearing mice.
Journal of immunology (Baltimore, Md. : 1950)
Narita Y,Kitamura H,Wakita D,Sumida K,Masuko K,Terada S,Nakano K,Nishimura T
Tue Jan 15 00:00:00 EST 2013
Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Liu B,Wang M,Wang X,Zhao D,Liu D,Liu J,Chen PJ,Yang D,He F,Tang L
Mon Apr 15 00:00:00 EDT 2013
Retinoid X receptor agonists modulate Foxp3⁺ regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation.
Journal of immunology (Baltimore, Md. : 1950)
Takeuchi H,Yokota-Nakatsuma A,Ohoka Y,Kagechika H,Kato C,Song SY,Iwata M
Tue Oct 01 00:00:00 EDT 2013
Tumor-derived vascular pericytes anergize Th cells.
Journal of immunology (Baltimore, Md. : 1950)
Bose A,Barik S,Banerjee S,Ghosh T,Mallick A,Bhattacharyya Majumdar S,Goswami KK,Bhuniya A,Banerjee S,Baral R,Storkus WJ,Dasgupta PS,Majumdar S
Mon Jul 15 00:00:00 EDT 2013
Cutaneous tumors cease CXCL9/Mig production as a result of IFN-γ-mediated immunoediting.
Journal of immunology (Baltimore, Md. : 1950)
Petro M,Kish D,Guryanova OA,Ilyinskaya G,Kondratova A,Fairchild RL,Gorbachev AV
Tue Jan 15 00:00:00 EST 2013
Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice.
Journal of immunology (Baltimore, Md. : 1950)
Waddell A,Ahrens R,Tsai YT,Sherrill JD,Denson LA,Steinbrecher KA,Hogan SP
Wed May 01 00:00:00 EDT 2013
Expression of CXCR3 on specific T cells is essential for homing to the prostate gland in an experimental model of chronic prostatitis/chronic pelvic pain syndrome.
Journal of immunology (Baltimore, Md. : 1950)
Breser ML,Motrich RD,Sanchez LR,Mackern-Oberti JP,Rivero VE
Mon Apr 01 00:00:00 EDT 2013
IFN-γ-induced priming maintains long-term strain-transcending immunity against blood-stage Plasmodium chabaudi malaria.
Journal of immunology (Baltimore, Md. : 1950)
da Silva HB,de Salles EM,Panatieri RH,Boscardin SB,Rodríguez-Málaga SM,Alvarez JM,D'Império Lima MR
Fri Nov 15 00:00:00 EST 2013
MyD88 signaling in CD4 T cells promotes IFN-γ production and hematopoietic progenitor cell expansion in response to intracellular bacterial infection.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Y,Jones M,McCabe A,Winslow GM,Avram D,MacNamara KC
Wed May 01 00:00:00 EDT 2013
Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model.
Journal of immunology (Baltimore, Md. : 1950)
Leung J,Suh WK
Sat Jun 15 00:00:00 EDT 2013
PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis.
Journal of immunology (Baltimore, Md. : 1950)
Chang HH,Miaw SC,Tseng W,Sun YW,Liu CC,Tsao HW,Ho IC
Sun Sep 01 00:00:00 EDT 2013
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ohta S,Imamura M,Xing W,Boyce JA,Balestrieri B
Sat Jun 15 00:00:00 EDT 2013
Microglial activation milieu controls regulatory T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Ebner F,Brandt C,Thiele P,Richter D,Schliesser U,Siffrin V,Schueler J,Stubbe T,Ellinghaus A,Meisel C,Sawitzki B,Nitsch R
Sun Dec 01 00:00:00 EST 2013
Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Han S,Jeong AL,Lee S,Park JS,Kim KD,Choi I,Yoon SR,Lee MS,Lim JS,Han SH,Yoon DY,Yang Y
Wed May 01 00:00:00 EDT 2013
Do β-cells generate peroxynitrite in response to cytokine treatment?
The Journal of biological chemistry
Broniowska KA,Mathews CE,Corbett JA
Fri Dec 20 00:00:00 EST 2013
Compensatory dendritic cell development mediated by BATF-IRF interactions.
Nature
Tussiwand R,Lee WL,Murphy TL,Mashayekhi M,KC W,Albring JC,Satpathy AT,Rotondo JA,Edelson BT,Kretzer NM,Wu X,Weiss LA,Glasmacher E,Li P,Liao W,Behnke M,Lam SS,Aurthur CT,Leonard WJ,Singh H,Stallings CL,Sibley LD,Schreiber RD,Murphy KM
Thu Oct 25 00:00:00 EDT 2012
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation.
Nature
Landsberg J,Kohlmeyer J,Renn M,Bald T,Rogava M,Cron M,Fatho M,Lennerz V,Wölfel T,Hölzel M,Tüting T
Thu Oct 18 00:00:00 EDT 2012
Prophage excision activates Listeria competence genes that promote phagosomal escape and virulence.
Cell
Rabinovich L,Sigal N,Borovok I,Nir-Paz R,Herskovits AA
Fri Aug 17 00:00:00 EDT 2012
Interferon-γ excess leads to pathogenic accumulation of follicular helper T cells and germinal centers.
Immunity
Lee SK,Silva DG,Martin JL,Pratama A,Hu X,Chang PP,Walters G,Vinuesa CG
Fri Nov 16 00:00:00 EST 2012
A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.
Immunity
Yamamoto M,Okuyama M,Ma JS,Kimura T,Kamiyama N,Saiga H,Ohshima J,Sasai M,Kayama H,Okamoto T,Huang DC,Soldati-Favre D,Horie K,Takeda J,Takeda K
Fri Aug 24 00:00:00 EDT 2012
IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis.
Blood
Attridge K,Wang CJ,Wardzinski L,Kenefeck R,Chamberlain JL,Manzotti C,Kopf M,Walker LS
Thu May 17 00:00:00 EDT 2012
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
Thu Feb 09 00:00:00 EST 2012
Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.
Blood
Everts B,Amiel E,van der Windt GJ,Freitas TC,Chott R,Yarasheski KE,Pearce EL,Pearce EJ
Thu Aug 16 00:00:00 EDT 2012
Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo.
Blood
Rückerl D,Jenkins SJ,Laqtom NN,Gallagher IJ,Sutherland TE,Duncan S,Buck AH,Allen JE
Thu Sep 13 00:00:00 EDT 2012
The Ets-1 transcription factor is required for Stat1-mediated T-bet expression and IgG2a class switching in mouse B cells.
Blood
Nguyen HV,Mouly E,Chemin K,Luinaud R,Despres R,Fermand JP,Arnulf B,Bories JC
Thu May 03 00:00:00 EDT 2012
TNF signaling drives myeloid-derived suppressor cell accumulation.
The Journal of clinical investigation
Zhao X,Rong L,Zhao X,Li X,Liu X,Deng J,Wu H,Xu X,Erben U,Wu P,Syrbe U,Sieper J,Qin Z
Thu Nov 01 00:00:00 EDT 2012
Epidermal growth factor receptor inhibits colitis-associated cancer in mice.
The Journal of clinical investigation
Dubé PE,Yan F,Punit S,Girish N,McElroy SJ,Washington MK,Polk DB
Wed Aug 01 00:00:00 EDT 2012
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.
The Journal of clinical investigation
Yiakouvaki A,Dimitriou M,Karakasiliotis I,Eftychi C,Theocharis S,Kontoyiannis DL
Sun Jan 01 00:00:00 EST 2012
Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis.
Kidney international
Paust HJ,Turner JE,Riedel JH,Disteldorf E,Peters A,Schmidt T,Krebs C,Velden J,Mittrücker HW,Steinmetz OM,Stahl RA,Panzer U
Sun Jul 01 00:00:00 EDT 2012
TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1.
The Journal of experimental medicine
Zhang M,Wang L,Zhao X,Zhao K,Meng H,Zhao W,Gao C
Mon Sep 24 00:00:00 EDT 2012
Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation.
Proceedings of the National Academy of Sciences of the United States of America
Malik M,Jividen K,Padmakumar VC,Cataisson C,Li L,Lee J,Howard OM,Yuspa SH
Tue Apr 17 00:00:00 EDT 2012
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Vaeth M,Schliesser U,Müller G,Reissig S,Satoh K,Tuettenberg A,Jonuleit H,Waisman A,Müller MR,Serfling E,Sawitzki BS,Berberich-Siebelt F
Tue Oct 02 00:00:00 EDT 2012
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Clark K,MacKenzie KF,Petkevicius K,Kristariyanto Y,Zhang J,Choi HG,Peggie M,Plater L,Pedrioli PG,McIver E,Gray NS,Arthur JS,Cohen P
Tue Oct 16 00:00:00 EDT 2012
Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
PLoS pathogens
Broadhurst MJ,Leung JM,Lim KC,Girgis NM,Gundra UM,Fallon PG,Premenko-Lanier M,McKerrow JH,McCune JM,Loke P
Mon Dec 17 00:00:00 EST 2012
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.
PLoS pathogens
Niedelman W,Gold DA,Rosowski EE,Sprokholt JK,Lim D,Farid Arenas A,Melo MB,Spooner E,Yaffe MB,Saeij JP
Fri Nov 09 00:00:00 EST 2012
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.
PLoS pathogens
Niedelman W,Gold DA,Rosowski EE,Sprokholt JK,Lim D,Farid Arenas A,Melo MB,Spooner E,Yaffe MB,Saeij JP
Fri Nov 09 00:00:00 EST 2012
Recombinant MPT83 derived from Mycobacterium tuberculosis induces cytokine production and upregulates the function of mouse macrophages through TLR2.
Journal of immunology (Baltimore, Md. : 1950)
Chen ST,Li JY,Zhang Y,Gao X,Cai H
Sun Jan 15 00:00:00 EST 2012
Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Eberle ME,Dalpke AH
Fri Jun 01 00:00:00 EDT 2012
Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.
Journal of immunology (Baltimore, Md. : 1950)
Kitamura H,Kobayashi M,Wakita D,Nishimura T
Tue May 01 00:00:00 EDT 2012
Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Schiffmann S,Ferreiros N,Birod K,Eberle M,Schreiber Y,Pfeilschifter W,Ziemann U,Pierre S,Scholich K,Grösch S,Geisslinger G
Fri Jun 01 00:00:00 EDT 2012
Smad3-deficient CD11b(+)Gr1(+) myeloid-derived suppressor cells prevent allograft rejection via the nitric oxide pathway.
Journal of immunology (Baltimore, Md. : 1950)
Wu T,Sun C,Chen Z,Zhen Y,Peng J,Qi Z,Yang X,Zhao Y
Thu Nov 15 00:00:00 EST 2012
Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions.
Journal of immunology (Baltimore, Md. : 1950)
Bian Z,Guo Y,Ha B,Zen K,Liu Y
Sun Jan 15 00:00:00 EST 2012
CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Ma L,Cheung KC,Kishore M,Nourshargh S,Mauro C,Marelli-Berg FM
Mon Oct 15 00:00:00 EDT 2012
Selective dependence of H2-M3-restricted CD8 responses on IL-15.
Journal of immunology (Baltimore, Md. : 1950)
Müller JR,Waldmann TA,Dubois S
Thu Mar 15 00:00:00 EDT 2012
E3 ubiquitin ligase tripartite motif 38 negatively regulates TLR-mediated immune responses by proteasomal degradation of TNF receptor-associated factor 6 in macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Zhao W,Wang L,Zhang M,Yuan C,Gao C
Thu Mar 15 00:00:00 EDT 2012
PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis.
Journal of immunology (Baltimore, Md. : 1950)
Tarrio ML,Grabie N,Bu DX,Sharpe AH,Lichtman AH
Tue May 15 00:00:00 EDT 2012
Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
Poovassery JS,Bishop GA
Wed Aug 15 00:00:00 EDT 2012
IL-22 mediates host defense against an intestinal intracellular parasite in the absence of IFN-γ at the cost of Th17-driven immunopathology.
Journal of immunology (Baltimore, Md. : 1950)
Stange J,Hepworth MR,Rausch S,Zajic L,Kühl AA,Uyttenhove C,Renauld JC,Hartmann S,Lucius R
Thu Mar 01 00:00:00 EST 2012
The Ifng gene is essential for Vdr gene expression and vitamin D₃-mediated reduction of the pathogenic T cell burden in the central nervous system in experimental autoimmune encephalomyelitis, a multiple sclerosis model.
Journal of immunology (Baltimore, Md. : 1950)
Spanier JA,Nashold FE,Olson JK,Hayes CE
Sat Sep 15 00:00:00 EDT 2012
Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?
Journal of immunology (Baltimore, Md. : 1950)
Abdi K,Singh NJ,Matzinger P
Fri Jun 15 00:00:00 EDT 2012
Discovery of a novel Toxoplasma gondii conoid-associated protein important for parasite resistance to reactive nitrogen intermediates.
Journal of immunology (Baltimore, Md. : 1950)
Skariah S,Bednarczyk RB,McIntyre MK,Taylor GA,Mordue DG
Sun Apr 01 00:00:00 EDT 2012
Transplanted mesoangioblasts require macrophage IL-10 for survival in a mouse model of muscle injury.
Journal of immunology (Baltimore, Md. : 1950)
Bosurgi L,Corna G,Vezzoli M,Touvier T,Cossu G,Manfredi AA,Brunelli S,Rovere-Querini P
Fri Jun 15 00:00:00 EDT 2012
NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950)
Staehli F,Ludigs K,Heinz LX,Seguín-Estévez Q,Ferrero I,Braun M,Schroder K,Rebsamen M,Tardivel A,Mattmann C,MacDonald HR,Romero P,Reith W,Guarda G,Tschopp J
Sun Apr 15 00:00:00 EDT 2012
Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950)
Ioannou M,Alissafi T,Lazaridis I,Deraos G,Matsoukas J,Gravanis A,Mastorodemos V,Plaitakis A,Sharpe A,Boumpas D,Verginis P
Wed Feb 01 00:00:00 EST 2012
Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.
Journal of immunology (Baltimore, Md. : 1950)
Volpi SA,Verma-Gaur J,Hassan R,Ju Z,Roa S,Chatterjee S,Werling U,Hou H,Will B,Steidl U,Scharff M,Edelman W,Feeney AJ,Birshtein BK
Thu Mar 15 00:00:00 EDT 2012
Metabolic characterization of Leishmania major infection in activated and nonactivated macrophages.
Journal of proteome research
Lamour SD,Choi BS,Keun HC,Müller I,Saric J
Fri Aug 03 00:00:00 EDT 2012
Soluble molecules are key in maintaining the immunomodulatory activity of murine mesenchymal stromal cells.
Journal of cell science
Liu H,Lu K,MacAry PA,Wong KL,Heng A,Cao T,Kemeny DM
315-05 was used in Sample Preparation (FC/FACS) to investigate immunotherapies in mesenchymal stromal cells.
Sun Jan 01 00:00:00 EST 2012
Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model.
Human molecular genetics
Tomassini B,Arcuri G,Fortuni S,Sandi C,Ezzatizadeh V,Casali C,Condò I,Malisan F,Al-Mahdawi S,Pook M,Testi R
Sun Jul 01 00:00:00 EDT 2012
The formation of complex acetylcholine receptor clusters requires MuSK kinase activity and structural information from the MuSK extracellular domain.
Molecular and cellular neurosciences
Mazhar S,Herbst R
Sun Apr 01 00:00:00 EDT 2012
CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments.
Genes and immunity
Zinzow-Kramer WM,Long AB,Youngblood BA,Rosenthal KM,Butler R,Mohammed AU,Skountzou I,Ahmed R,Evavold BD,Boss JM
Fri Jun 01 00:00:00 EDT 2012
Inchingorei-san (TJ-117) and Artemisiae Capillaris Herba Induced Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice.
Evidence-based complementary and alternative medicine : eCAM
Jin X,Uchiyama M,Zhang Q,Hirai T,Niimi M
Thu Aug 23 00:00:00 EDT 2012
TGFβ signaling plays a critical role in promoting alternative macrophage activation.
BMC immunology
Gong D,Shi W,Yi SJ,Chen H,Groffen J,Heisterkamp N
Fri Jun 15 00:00:00 EDT 2012
Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo.
The Journal of biological chemistry
Bernard JK,McCann SP,Bhardwaj V,Washington MK,Frey MR
Fri Nov 16 00:00:00 EST 2012
Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo.
The Journal of biological chemistry
Bernard JK,McCann SP,Bhardwaj V,Washington MK,Frey MR
Fri Nov 16 00:00:00 EST 2012
Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins.
The Journal of biological chemistry
Robbins GR,Truax AD,Davis BK,Zhang L,Brickey WJ,Ting JP
Fri Jul 13 00:00:00 EDT 2012
Thioredoxin-1 regulates cellular heme insertion by controlling S-nitrosation of glyceraldehyde-3-phosphate dehydrogenase.
The Journal of biological chemistry
Chakravarti R,Stuehr DJ
Fri May 11 00:00:00 EDT 2012
Role of the tumor suppressor ARF in macrophage polarization: Enhancement of the M2 phenotype in ARF-deficient mice.
Oncoimmunology
Herranz S,Través PG,Luque A,Hortelano S
Thu Nov 01 00:00:00 EDT 2012
Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity.
PloS one
Banik D,Khan AN,Walseng E,Segal BH,Abrams SI
Mon Feb 25 00:00:00 EST 2013
In vitro phenotypic, genomic and proteomic characterization of a cytokine-resistant murine β-TC3 cell line.
PloS one
Coppola A,Tomasello L,Pizzolanti G,Pucci-Minafra I,Albanese N,Di Cara G,Cancemi P,Pitrone M,Bommarito A,Carissimi E,Zito G,Criscimanna A,Galluzzo A,Giordano C
Mon Jul 23 00:00:00 EDT 2012
Severe Developmental B Lymphopoietic Defects in Foxp3-Deficient Mice are Refractory to Adoptive Regulatory T Cell Therapy.
Frontiers in immunology
Riewaldt J,Düber S,Boernert M,Krey M,Dembinski M,Weiss S,Garbe AI,Kretschmer K
Thu Aug 23 00:00:00 EDT 2012
Dietary rice bran promotes resistance to Salmonella enterica serovar Typhimurium colonization in mice.
BMC microbiology
Kumar A,Henderson A,Forster GM,Goodyear AW,Weir TL,Leach JE,Dow SW,Ryan EP
Wed Jul 04 00:00:00 EDT 2012
The p50 subunit of NF-κB orchestrates dendritic cell lifespan and activation of adaptive immunity.
PloS one
Larghi P,Porta C,Riboldi E,Totaro MG,Carraro L,Orabona C,Sica A
Mon Apr 22 00:00:00 EDT 2013
Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.
The Journal of biological chemistry
Müller JR,Waldmann TA,Kruhlak MJ,Dubois S
Fri Nov 23 00:00:00 EST 2012
Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4+CD25+ cells.
Journal of cardiothoracic surgery
Uchiyama M,Jin X,Zhang Q,Hirai T,Amano A,Bashuda H,Niimi M
Fri Mar 23 00:00:00 EDT 2012
Schistosoma japonicum soluble egg antigens attenuate IFN-γ-induced MHC class II expression in RAW 264.7 macrophages.
PloS one
Tang GX,Zhou HJ,Xu JW,Xu JM,Ji MJ,Wu HW,Wu GL
Tue May 07 00:00:00 EDT 2013
High avidity cytotoxic T lymphocytes can be selected into the memory pool but they are exquisitely sensitive to functional impairment.
PloS one
Brentville VA,Metheringham RL,Gunn B,Durrant LG
Fri Dec 07 00:00:00 EST 2012
Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis.
Blood
Libregts SF,Gutiérrez L,de Bruin AM,Wensveen FM,Papadopoulos P,van Ijcken W,Ozgür Z,Philipsen S,Nolte MA
Thu Sep 01 00:00:00 EDT 2011
Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells.
Blood
Kanada S,Nishiyama C,Nakano N,Suzuki R,Maeda K,Hara M,Kitamura N,Ogawa H,Okumura K
Thu Feb 17 00:00:00 EST 2011
P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice.
The Journal of clinical investigation
Furlan-Freguia C,Marchese P,Gruber A,Ruggeri ZM,Ruf W
Fri Jul 01 00:00:00 EDT 2011
Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner.
The Journal of clinical investigation
Woo KV,Qu X,Babaev VR,Linton MF,Guzman RJ,Fazio S,Baldwin HS
Fri Apr 01 00:00:00 EDT 2011
Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma.
The Journal of clinical investigation
Yu M,Eckart MR,Morgan AA,Mukai K,Butte AJ,Tsai M,Galli SJ
Mon Aug 01 00:00:00 EDT 2011
Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice.
The Journal of clinical investigation
Nosaka M,Ishida Y,Kimura A,Kuninaka Y,Inui M,Mukaida N,Kondo T
Fri Jul 01 00:00:00 EDT 2011
Hemophagocytosis causes a consumptive anemia of inflammation.
The Journal of experimental medicine
Zoller EE,Lykens JE,Terrell CE,Aliberti J,Filipovich AH,Henson PM,Jordan MB
Mon Jun 06 00:00:00 EDT 2011
Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway.
The Journal of experimental medicine
Potian JA,Rafi W,Bhatt K,McBride A,Gause WC,Salgame P
Mon Aug 29 00:00:00 EDT 2011
Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells.
The Journal of experimental medicine
Molon B,Ugel S,Del Pozzo F,Soldani C,Zilio S,Avella D,De Palma A,Mauri P,Monegal A,Rescigno M,Savino B,Colombo P,Jonjic N,Pecanic S,Lazzarato L,Fruttero R,Gasco A,Bronte V,Viola A
Mon Sep 26 00:00:00 EDT 2011
NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses.
The Journal of experimental medicine
Hofmann J,Mair F,Greter M,Schmidt-Supprian M,Becher B
Mon Aug 29 00:00:00 EDT 2011
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
The Journal of experimental medicine
Wang L,Rubinstein R,Lines JL,Wasiuk A,Ahonen C,Guo Y,Lu LF,Gondek D,Wang Y,Fava RA,Fiser A,Almo S,Noelle RJ
Mon Mar 14 00:00:00 EDT 2011
Differential down-modulation of HLA class I and II molecule expression on human tumor cell lines upon in vivo transfer.
Cancer immunology, immunotherapy : CII
Turrini R,Merlo A,Dolcetti R,Zanovello P,Rosato A
Tue Nov 01 00:00:00 EDT 2011
Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis.
Stem cells (Dayton, Ohio)
Duijvestein M,Wildenberg ME,Welling MM,Hennink S,Molendijk I,van Zuylen VL,Bosse T,Vos AC,de Jonge-Muller ES,Roelofs H,van der Weerd L,Verspaget HW,Fibbe WE,te Velde AA,van den Brink GR,Hommes DW
Sat Oct 01 00:00:00 EDT 2011
Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate.
Arthritis research & therapy
Lu Y,Stinnette TW,Westrick E,Klein PJ,Gehrke MA,Cross VA,Vlahov IR,Low PS,Leamon CP
Mon Apr 04 00:00:00 EDT 2011
A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Qi HY,Daniels MP,Liu Y,Chen LY,Alsaaty S,Levine SJ,Shelhamer JH
Tue Nov 15 00:00:00 EST 2011
Nephrotic syndrome and subepithelial deposits in a mouse model of immune-mediated anti-podocyte glomerulonephritis.
Journal of immunology (Baltimore, Md. : 1950)
Meyer-Schwesinger C,Dehde S,Klug P,Becker JU,Mathey S,Arefi K,Balabanov S,Venz S,Endlich KH,Pekna M,Gessner JE,Thaiss F,Meyer TN
Thu Sep 15 00:00:00 EDT 2011
High TCR stimuli prevent induced regulatory T cell differentiation in a NF-κB-dependent manner.
Journal of immunology (Baltimore, Md. : 1950)
Molinero LL,Miller ML,Evaristo C,Alegre ML
Fri Apr 15 00:00:00 EDT 2011
Glycogen synthase kinase-3 facilitates con a-induced IFN-γ-- mediated immune hepatic injury.
Journal of immunology (Baltimore, Md. : 1950)
Tsai CC,Huang WC,Chen CL,Hsieh CY,Lin YS,Chen SH,Yang KC,Lin CF
Sat Oct 01 00:00:00 EDT 2011
CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Erhardt A,Wegscheid C,Claass B,Carambia A,Herkel J,Mittrücker HW,Panzer U,Tiegs G
Sun May 01 00:00:00 EDT 2011
Sensitivity and resistance to regulation by IL-4 during Th17 maturation.
Journal of immunology (Baltimore, Md. : 1950)
Cooney LA,Towery K,Endres J,Fox DA
Tue Nov 01 00:00:00 EDT 2011
CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition.
Journal of immunology (Baltimore, Md. : 1950)
Barber DL,Mayer-Barber KD,Feng CG,Sharpe AH,Sher A
Tue Feb 01 00:00:00 EST 2011
A p53 defect sensitizes various stages of B cell development to lymphomagenesis in mice carrying an IgH 3' regulatory region-driven c-myc transgene.
Journal of immunology (Baltimore, Md. : 1950)
Fiancette R,Rouaud P,Vincent-Fabert C,Laffleur B,Magnone V,Cogné M,Denizot Y
Thu Dec 01 00:00:00 EST 2011
A small molecule deubiquitinase inhibitor increases localization of inducible nitric oxide synthase to the macrophage phagosome and enhances bacterial killing.
Infection and immunity
Burkholder KM,Perry JW,Wobus CE,Donato NJ,Showalter HD,Kapuria V,O'Riordan MX
315-05 was used in Cell Culture to indicate that the deubiquitinase inhibitor WP1130 increases bacterial killing in macrophages by enhancing iNOS localization to the phagosome and suggest a potential role for ubiquitin regulation in iNOS trafficking.
Thu Dec 01 00:00:00 EST 2011
Concanavalin A/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption.
PloS one
Chang CP,Yang MC,Lei HY
Fri Jul 20 00:00:00 EDT 2012
HIV-1 Tat activates indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen-activated protein kinase-dependent manner.
Journal of neuroinflammation
Fu X,Lawson MA,Kelley KW,Dantzer R
Tue Aug 02 00:00:00 EDT 2011
Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma.
The Journal of biological chemistry
Goto Y,Ogawa K,Hattori A,Tsujimoto M
Fri Jun 17 00:00:00 EDT 2011
Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.
PloS one
Takeuchi H,Yokota A,Ohoka Y,Iwata M
Fri Jan 07 00:00:00 EST 2011
Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance.
Nature communications
Chinen T,Komai K,Muto G,Morita R,Inoue N,Yoshida H,Sekiya T,Yoshida R,Nakamura K,Takayanagi R,Yoshimura A
Tue Feb 08 00:00:00 EST 2011
The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii.
BMC biology
Pawlowski N,Khaminets A,Hunn JP,Papic N,Schmidt A,Uthaiah RC,Lange R,Vopper G,Martens S,Wolf E,Howard JC
Fri Jan 28 00:00:00 EST 2011
Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer.
The Journal of biological chemistry
Liu Y,Han ZP,Zhang SS,Jing YY,Bu XX,Wang CY,Sun K,Jiang GC,Zhao X,Li R,Gao L,Zhao QD,Wu MC,Wei LX
Fri Jul 15 00:00:00 EDT 2011
Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it.
PloS one
Virreira Winter S,Niedelman W,Jensen KD,Rosowski EE,Julien L,Spooner E,Caradonna K,Burleigh BA,Saeij JP,Ploegh HL,Frickel EM
Fri Jun 08 00:00:00 EDT 2012
Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1).
The Journal of biological chemistry
Corcoran K,Jabbour M,Bhagwandin C,Deymier MJ,Theisen DL,Lybarger L
Fri Oct 28 00:00:00 EDT 2011
MHC mismatch inhibits neurogenesis and neuron maturation in stem cell allografts.
PloS one
Chen Z,Phillips LK,Gould E,Campisi J,Lee SW,Ormerod BK,Zwierzchoniewska M,Martinez OM,Palmer TD
Wed Mar 30 00:00:00 EDT 2011
Regulation of T cell priming by lymphoid stroma.
PloS one
Khan O,Headley M,Gerard A,Wei W,Liu L,Krummel MF
Mon Mar 26 00:00:00 EDT 2012
Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.
PloS one
Siegert S,Huang HY,Yang CY,Scarpellino L,Carrie L,Essex S,Nelson PJ,Heikenwalder M,Acha-Orbea H,Buckley CD,Marsland BJ,Zehn D,Luther SA
Mon Mar 26 00:00:00 EDT 2012
STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.
Immunity
Szanto A,Balint BL,Nagy ZS,Barta E,Dezso B,Pap A,Szeles L,Poliska S,Oros M,Evans RM,Barak Y,Schwabe J,Nagy L
Wed Nov 24 00:00:00 EST 2010
Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma.
Blood
de Bruin AM,Buitenhuis M,van der Sluijs KF,van Gisbergen KP,Boon L,Nolte MA
Thu Oct 07 00:00:00 EDT 2010
IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury.
The Journal of clinical investigation
Li L,Huang L,Vergis AL,Ye H,Bajwa A,Narayan V,Strieter RM,Rosin DL,Okusa MD
Fri Jan 01 00:00:00 EST 2010
IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury.
The Journal of clinical investigation
Li L,Huang L,Vergis AL,Ye H,Bajwa A,Narayan V,Strieter RM,Rosin DL,Okusa MD
Fri Jan 01 00:00:00 EST 2010
Primary murine microglia are resistant to nitric oxide inhibition of indoleamine 2,3-dioxygenase.
Brain, behavior, and immunity
Wang Y,Lawson MA,Kelley KW,Dantzer R
315-05 was used in Cell Culture to investigate nitric oxide inhibition of proinflammatory activation of heme-containing enzymes.
Mon Nov 01 00:00:00 EDT 2010
TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis.
The Journal of experimental medicine
Noti M,Corazza N,Mueller C,Berger B,Brunner T
Mon May 10 00:00:00 EDT 2010
CD11c depletion severely disrupts Th2 induction and development in vivo.
The Journal of experimental medicine
Phythian-Adams AT,Cook PC,Lundie RJ,Jones LH,Smith KA,Barr TA,Hochweller K,Anderton SM,Hämmerling GJ,Maizels RM,MacDonald AS
Mon Sep 27 00:00:00 EDT 2010
Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents.
Proceedings of the National Academy of Sciences of the United States of America
Zhou B,He Y,Zhang X,Xu J,Luo Y,Wang Y,Franzblau SG,Yang Z,Chan RJ,Liu Y,Zheng J,Zhang ZY
Tue Mar 09 00:00:00 EST 2010
NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes.
Proceedings of the National Academy of Sciences of the United States of America
Rybicka JM,Balce DR,Khan MF,Krohn RM,Yates RM
Tue Jun 08 00:00:00 EDT 2010
PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions.
Mucosal immunology
Akbari O,Stock P,Singh AK,Lombardi V,Lee WL,Freeman GJ,Sharpe AH,Umetsu DT,Dekruyff RH
Fri Jan 01 00:00:00 EST 2010
The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation.
The Journal of cell biology
Kuang Z,Lewis RS,Curtis JM,Zhan Y,Saunders BM,Babon JJ,Kolesnik TB,Low A,Masters SL,Willson TA,Kedzierski L,Yao S,Handman E,Norton RS,Nicholson SE
Mon Jul 12 00:00:00 EDT 2010
Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival.
PLoS pathogens
Homolka S,Niemann S,Russell DG,Rohde KH
Thu Jul 08 00:00:00 EDT 2010
Chemerin contributes to inflammation by promoting macrophage adhesion to VCAM-1 and fibronectin through clustering of VLA-4 and VLA-5.
Journal of immunology (Baltimore, Md. : 1950)
Hart R,Greaves DR
Wed Sep 15 00:00:00 EDT 2010
CCR2 plays a critical role in dendritic cell maturation: possible role of CCL2 and NF-kappa B.
Journal of immunology (Baltimore, Md. : 1950)
Jimenez F,Quinones MP,Martinez HG,Estrada CA,Clark K,Garavito E,Ibarra J,Melby PC,Ahuja SS
Sat May 15 00:00:00 EDT 2010
Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection.
Journal of immunology (Baltimore, Md. : 1950)
Goodyear A,Jones A,Troyer R,Bielefeldt-Ohmann H,Dow S
Mon Feb 01 00:00:00 EST 2010
Virus-specific cytotoxic CD4+ T cells for the treatment of EBV-related tumors.
Journal of immunology (Baltimore, Md. : 1950)
Merlo A,Turrini R,Bobisse S,Zamarchi R,Alaggio R,Dolcetti R,Mautner J,Zanovello P,Amadori A,Rosato A
Sat May 15 00:00:00 EDT 2010
In vivo redundant function of the 3' IgH regulatory element HS3b in the mouse.
Journal of immunology (Baltimore, Md. : 1950)
Bébin AG,Carrion C,Marquet M,Cogné N,Lecardeur S,Cogné M,Pinaud E
Thu Apr 01 00:00:00 EDT 2010
Hypochlorous acid: a natural adjuvant that facilitates antigen processing, cross-priming, and the induction of adaptive immunity.
Journal of immunology (Baltimore, Md. : 1950)
Prokopowicz ZM,Arce F,Biedroń R,Chiang CL,Ciszek M,Katz DR,Nowakowska M,Zapotoczny S,Marcinkiewicz J,Chain BM
Fri Jan 15 00:00:00 EST 2010
Immune dysregulation by the rheumatoid arthritis shared epitope.
Journal of immunology (Baltimore, Md. : 1950)
De Almeida DE,Ling S,Pi X,Hartmann-Scruggs AM,Pumpens P,Holoshitz J
Sun Aug 01 00:00:00 EDT 2010
NK cells influence both innate and adaptive immune responses after mucosal immunization with antigen and mucosal adjuvant.
Journal of immunology (Baltimore, Md. : 1950)
Hall LJ,Clare S,Dougan G
Thu Apr 15 00:00:00 EDT 2010
Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice.
Journal of immunology (Baltimore, Md. : 1950)
Johannsen A,Genolet R,Legler DF,Luther SA,Luescher IF
Wed Sep 15 00:00:00 EDT 2010
p53 represses class switch recombination to IgG2a through its antioxidant function.
Journal of immunology (Baltimore, Md. : 1950)
Guikema JE,Schrader CE,Brodsky MH,Linehan EK,Richards A,El Falaky N,Li DH,Sluss HK,Szomolanyi-Tsuda E,Stavnezer J
Tue Jun 01 00:00:00 EDT 2010
Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination.
Journal of immunology (Baltimore, Md. : 1950)
Li F,Yan Y,Pieretti J,Feldman DA,Eckhardt LA
Mon Nov 15 00:00:00 EST 2010
The interactions of multiple cytokines control NK cell maturation.
Journal of immunology (Baltimore, Md. : 1950)
Brady J,Carotta S,Thong RP,Chan CJ,Hayakawa Y,Smyth MJ,Nutt SL
Wed Dec 01 00:00:00 EST 2010
Crucial role of phospholipase Cepsilon in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity.
Journal of immunology (Baltimore, Md. : 1950)
Hu L,Edamatsu H,Takenaka N,Ikuta S,Kataoka T
Fri Jan 15 00:00:00 EST 2010
Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kastner L,Dwyer D,Qin FX
Mon Nov 15 00:00:00 EST 2010
IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Li JJ,Wang W,Baines KJ,Bowden NA,Hansbro PM,Gibson PG,Kumar RK,Foster PS,Yang M
Fri Oct 01 00:00:00 EDT 2010
Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Outtz HH,Wu JK,Wang X,Kitajewski J
Fri Oct 01 00:00:00 EDT 2010
Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins.
Journal of immunology (Baltimore, Md. : 1950)
Takeuchi H,Yokota A,Ohoka Y,Kagechika H,Kato C,Song SY,Iwata M
Mon Nov 01 00:00:00 EDT 2010
Peroxynitrite-dependent killing of cancer cells and presentation of released tumor antigens by activated dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Fraszczak J,Trad M,Janikashvili N,Cathelin D,Lakomy D,Granci V,Morizot A,Audia S,Micheau O,Lagrost L,Katsanis E,Solary E,Larmonier N,Bonnotte B
Mon Feb 15 00:00:00 EST 2010
Tumor cell-released TLR4 ligands stimulate Gr-1+CD11b+F4/80+ cells to induce apoptosis of activated T cells.
Journal of immunology (Baltimore, Md. : 1950)
Liu YY,Sun LC,Wei JJ,Li D,Yuan Y,Yan B,Liang ZH,Zhu HF,Xu Y,Li B,Song CW,Liao SJ,Lei Z,Zhang GM,Feng ZH
Wed Sep 01 00:00:00 EDT 2010
Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation.
Journal of immunology (Baltimore, Md. : 1950)
Rodríguez-Prados JC,Través PG,Cuenca J,Rico D,Aragonés J,Martín-Sanz P,Cascante M,Boscá L
Thu Jul 01 00:00:00 EDT 2010
12/15-lipoxygenase is an interleukin-13 and interferon-γ counterregulated-mediator of allergic airway inflammation.
Mediators of inflammation
Lindley AR,Crapster-Pregont M,Liu Y,Kuperman DA
Wed Feb 02 00:00:00 EST 2011
Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.
Cellular microbiology
Khaminets A,Hunn JP,Könen-Waisman S,Zhao YO,Preukschat D,Coers J,Boyle JP,Ong YC,Boothroyd JC,Reichmann G,Howard JC
Thu Jul 01 00:00:00 EDT 2010
Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.
Cellular microbiology
Khaminets A,Hunn JP,Könen-Waisman S,Zhao YO,Preukschat D,Coers J,Boyle JP,Ong YC,Boothroyd JC,Reichmann G,Howard JC
Thu Jul 01 00:00:00 EDT 2010
The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels.
PloS one
Portillo JA,Okenka G,Reed E,Subauste A,Van Grol J,Gentil K,Komatsu M,Tanaka K,Landreth G,Levine B,Subauste CS
Fri Dec 31 00:00:00 EST 2010
Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells.
The Journal of biological chemistry
Humphrey RK,Newcomb CJ,Yu SM,Hao E,Yu D,Krajewski S,Du K,Jhala US
Fri Jul 16 00:00:00 EDT 2010
Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells.
BMC neuroscience
Cohn ZJ,Kim A,Huang L,Brand J,Wang H
Thu Jun 10 00:00:00 EDT 2010
Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.
Journal of neuroinflammation
Dohi K,Ohtaki H,Nakamachi T,Yofu S,Satoh K,Miyamoto K,Song D,Tsunawaki S,Shioda S,Aruga T
Mon Jul 26 00:00:00 EDT 2010
The inhibitory effect against collagen-induced arthritis by Schistosoma japonicum infection is infection stage-dependent.
BMC immunology
He Y,Li J,Zhuang W,Yin L,Chen C,Li J,Chi F,Bai Y,Chen XP
Thu Jun 10 00:00:00 EDT 2010
N-type calcium channel in the pathogenesis of experimental autoimmune encephalomyelitis.
The Journal of biological chemistry
Tokuhara N,Namiki K,Uesugi M,Miyamoto C,Ohgoh M,Ido K,Yoshinaga T,Yamauchi T,Kuromitsu J,Kimura S,Miyamoto N,Kasuya Y
Fri Oct 22 00:00:00 EDT 2010
Comparative proteomic analysis of Salmonella enterica serovar Typhimurium ppGpp-deficient mutant to identify a novel virulence protein required for intracellular survival in macrophages.
BMC microbiology
Haneda T,Sugimoto M,Yoshida-Ohta Y,Kodera Y,Oh-Ishi M,Maeda T,Shimizu-Izumi S,Miki T,Kumagai Y,Danbara H,Okada N
Tue Dec 21 00:00:00 EST 2010
Modulation of agrin-induced acetylcholine receptor clustering by extracellular signal-regulated kinases 1 and 2 in cultured myotubes.
The Journal of biological chemistry
Rimer M
Fri Oct 15 00:00:00 EDT 2010
Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells.
PloS one
Zhao YO,Könen-Waisman S,Taylor GA,Martens S,Howard JC
Wed Jan 13 00:00:00 EST 2010
In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response.
PloS one
Akagi T,Thoennissen NH,George A,Crooks G,Song JH,Okamoto R,Nowak D,Gombart AF,Koeffler HP
Wed Nov 03 00:00:00 EDT 2010
Interferon-gamma produced by microglia and the neuropeptide PACAP have opposite effects on the viability of neural progenitor cells.
PloS one
Mäkelä J,Koivuniemi R,Korhonen L,Lindholm D
Mon Jun 14 00:00:00 EDT 2010
Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells.
The Journal of biological chemistry
Denda-Nagai K,Aida S,Saba K,Suzuki K,Moriyama S,Oo-Puthinan S,Tsuiji M,Morikawa A,Kumamoto Y,Sugiura D,Kudo A,Akimoto Y,Kawakami H,Bovin NV,Irimura T
Fri Jun 18 00:00:00 EDT 2010
Autophagy facilitates IFN-gamma-induced Jak2-STAT1 activation and cellular inflammation.
The Journal of biological chemistry
Chang YP,Tsai CC,Huang WC,Wang CY,Chen CL,Lin YS,Kai JI,Hsieh CY,Cheng YL,Choi PC,Chen SH,Chang SP,Liu HS,Lin CF
Fri Sep 10 00:00:00 EDT 2010
The AP-1 transcription factor Batf controls T(H)17 differentiation.
Nature
Schraml BU,Hildner K,Ise W,Lee WL,Smith WA,Solomon B,Sahota G,Sim J,Mukasa R,Cemerski S,Hatton RD,Stormo GD,Weaver CT,Russell JH,Murphy TL,Murphy KM
Thu Jul 16 00:00:00 EDT 2009
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.
Cancer cell
DeNardo DG,Barreto JB,Andreu P,Vasquez L,Tawfik D,Kolhatkar N,Coussens LM
Tue Aug 04 00:00:00 EDT 2009
T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue.
Blood
David R,Ma L,Ivetic A,Takesono A,Ridley AJ,Chai JG,Tybulewicz VL,Marelli-Berg FM
Thu Apr 16 00:00:00 EDT 2009
Spatiotemporal regulation of intracellular trafficking of Toll-like receptor 9 by an inhibitory receptor, Ly49Q.
Blood
Yoshizaki M,Tazawa A,Kasumi E,Sasawatari S,Itoh K,Dohi T,Sasazuki T,Inaba K,Makrigiannis AP,Toyama-Sorimachi N
Thu Aug 20 00:00:00 EDT 2009
Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.
Blood
Koenen RR,Pruessmeyer J,Soehnlein O,Fraemohs L,Zernecke A,Schwarz N,Reiss K,Sarabi A,Lindbom L,Hackeng TM,Weber C,Ludwig A
Thu May 07 00:00:00 EDT 2009
Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.
Blood
Klebanoff CA,Yu Z,Hwang LN,Palmer DC,Gattinoni L,Restifo NP
Thu Aug 27 00:00:00 EDT 2009
Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells.
Blood
Milsom MD,Schiedlmeier B,Bailey J,Kim MO,Li D,Jansen M,Ali AM,Kirby M,Baum C,Fairbairn LJ,Williams DA
Thu May 21 00:00:00 EDT 2009
Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.
The Journal of experimental medicine
Nolting J,Daniel C,Reuter S,Stuelten C,Li P,Sucov H,Kim BG,Letterio JJ,Kretschmer K,Kim HJ,von Boehmer H
Mon Sep 28 00:00:00 EDT 2009
Ikaros controls isotype selection during immunoglobulin class switch recombination.
The Journal of experimental medicine
Sellars M,Reina-San-Martin B,Kastner P,Chan S
Mon May 11 00:00:00 EDT 2009
Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse.
The Journal of experimental medicine
Maldonado RA,Soriano MA,Perdomo LC,Sigrist K,Irvine DJ,Decker T,Glimcher LH
Mon Apr 13 00:00:00 EDT 2009
Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination.
The Journal of experimental medicine
Robert I,Dantzer F,Reina-San-Martin B
Mon May 11 00:00:00 EDT 2009
Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates.
The EMBO journal
Pelegrin P,Surprenant A
Wed Jul 22 00:00:00 EDT 2009
HPV16 tumor associated macrophages suppress antitumor T cell responses.
Clinical cancer research : an official journal of the American Association for Cancer Research
Lepique AP,Daghastanli KR,Cuccovia IM,Villa LL
Wed Jul 01 00:00:00 EDT 2009
CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes.
Proceedings of the National Academy of Sciences of the United States of America
Niedermeier M,Reich B,Rodriguez Gomez M,Denzel A,Schmidbauer K,Göbel N,Talke Y,Schweda F,Mack M
Tue Oct 20 00:00:00 EDT 2009
A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair.
Proceedings of the National Academy of Sciences of the United States of America
Ruffell D,Mourkioti F,Gambardella A,Kirstetter P,Lopez RG,Rosenthal N,Nerlov C
Tue Oct 13 00:00:00 EDT 2009
IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction.
Proceedings of the National Academy of Sciences of the United States of America
Wang M,Tan J,Wang Y,Meldrum KK,Dinarello CA,Meldrum DR
Tue Oct 13 00:00:00 EDT 2009
STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response.
Journal of biomedical science
Chen LS,Wei PC,Liu T,Kao CH,Pai LM,Lee CK
Thu Feb 19 00:00:00 EST 2009
Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis.
The Journal of investigative dermatology
Kim BS,Miyagawa F,Cho YH,Bennett CL,Clausen BE,Katz SI
Tue Dec 01 00:00:00 EST 2009
Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death.
PLoS pathogens
Zhao YO,Khaminets A,Hunn JP,Howard JC
Sun Feb 01 00:00:00 EST 2009
Reevaluating the CD8 T-cell response to herpes simplex virus type 1: involvement of CD8 T cells reactive to subdominant epitopes.
Journal of virology
Sheridan BS,Cherpes TL,Urban J,Kalinski P,Hendricks RL
Sun Mar 01 00:00:00 EST 2009
Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages.
Journal of leukocyte biology
Choi BS,Martinez-Falero IC,Corset C,Munder M,Modolell M,Müller I,Kropf P
Sun Feb 01 00:00:00 EST 2009
Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Kambayashi T,Allenspach EJ,Chang JT,Zou T,Shoag JE,Reiner SL,Caton AJ,Koretzky GA
Wed Apr 15 00:00:00 EDT 2009
Suppression of autoimmune diabetes by soluble galectin-1.
Journal of immunology (Baltimore, Md. : 1950)
Perone MJ,Bertera S,Shufesky WJ,Divito SJ,Montecalvo A,Mathers AR,Larregina AT,Pang M,Seth N,Wucherpfennig KW,Trucco M,Baum LG,Morelli AE
Sun Mar 01 00:00:00 EST 2009
Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways.
Journal of immunology (Baltimore, Md. : 1950)
Aleyas AG,George JA,Han YW,Rahman MM,Kim SJ,Han SB,Kim BS,Kim K,Eo SK
Sat Aug 15 00:00:00 EDT 2009
Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.
Journal of immunology (Baltimore, Md. : 1950)
Mielke LA,Elkins KL,Wei L,Starr R,Tsichlis PN,O'Shea JJ,Watford WT
Tue Dec 15 00:00:00 EST 2009
Autophagic compartments gain access to the MHC class II compartments in thymic epithelium.
Journal of immunology (Baltimore, Md. : 1950)
Kasai M,Tanida I,Ueno T,Kominami E,Seki S,Ikeda T,Mizuochi T
Tue Dec 01 00:00:00 EST 2009
The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity.
Journal of immunology (Baltimore, Md. : 1950)
Kim JY,Ozato K
Sun Feb 15 00:00:00 EST 2009
Differential use of CARD9 by dectin-1 in macrophages and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Goodridge HS,Shimada T,Wolf AJ,Hsu YM,Becker CA,Lin X,Underhill DM
Thu Jan 15 00:00:00 EST 2009
Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity.
Journal of immunology (Baltimore, Md. : 1950)
Schreiber T,Ehlers S,Heitmann L,Rausch A,Mages J,Murray PJ,Lang R,Hölscher C
Wed Jul 15 00:00:00 EDT 2009
Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid.
Journal of immunology (Baltimore, Md. : 1950)
Griffith JW,Sun T,McIntosh MT,Bucala R
Thu Oct 15 00:00:00 EDT 2009
Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation.
Journal of immunology (Baltimore, Md. : 1950)
Franchi L,Eigenbrod T,Núñez G
Wed Jul 15 00:00:00 EDT 2009
HSV-1-induced SOCS-1 expression in keratinocytes: use of a SOCS-1 antagonist to block a novel mechanism of viral immune evasion.
Journal of immunology (Baltimore, Md. : 1950)
Frey KG,Ahmed CM,Dabelic R,Jager LD,Noon-Song EN,Haider SM,Johnson HM,Bigley NJ
Wed Jul 15 00:00:00 EDT 2009
Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-gamma and TLR4/MyD88 pathways.
Journal of immunology (Baltimore, Md. : 1950)
Yang M,Kumar RK,Foster PS
Wed Apr 15 00:00:00 EDT 2009
Central role of tumor-associated CD8+ T effector/memory cells in restoring systemic antitumor immunity.
Journal of immunology (Baltimore, Md. : 1950)
Kilinc MO,Gu T,Harden JL,Virtuoso LP,Egilmez NK
Wed Apr 01 00:00:00 EDT 2009
MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression.
Journal of immunology (Baltimore, Md. : 1950)
Enzler T,Chang X,Facchinetti V,Melino G,Karin M,Su B,Gallagher E
Tue Sep 15 00:00:00 EDT 2009
IL-23 is required for protection against systemic infection with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Meeks KD,Sieve AN,Kolls JK,Ghilardi N,Berg RE
Tue Dec 15 00:00:00 EST 2009
SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Starr R,Fuchsberger M,Lau LS,Uldrich AP,Goradia A,Willson TA,Verhagen AM,Alexander WS,Smyth MJ
Thu Oct 01 00:00:00 EDT 2009
4-1BB functions as a survival factor in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Choi BK,Kim YH,Kwon PM,Lee SC,Kang SW,Kim MS,Lee MJ,Kwon BS
Wed Apr 01 00:00:00 EDT 2009
A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Perona-Wright G,Jenkins SJ,O'Connor RA,Zienkiewicz D,McSorley HJ,Maizels RM,Anderton SM,MacDonald AS
Sun Mar 01 00:00:00 EST 2009
CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching/effacing lesion-forming bacterial pathogen.
Journal of immunology (Baltimore, Md. : 1950)
Spehlmann ME,Dann SM,Hruz P,Hanson E,McCole DF,Eckmann L
Tue Sep 01 00:00:00 EDT 2009
Ig synthesis and class switching do not require the presence of the hs4 enhancer in the 3' IgH regulatory region.
Journal of immunology (Baltimore, Md. : 1950)
Vincent-Fabert C,Truffinet V,Fiancette R,Cogné N,Cogné M,Denizot Y
Mon Jun 01 00:00:00 EDT 2009
Glycogen synthase kinase-3beta facilitates IFN-gamma-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2.
Journal of immunology (Baltimore, Md. : 1950)
Tsai CC,Kai JI,Huang WC,Wang CY,Wang Y,Chen CL,Fang YT,Lin YS,Anderson R,Chen SH,Tsao CW,Lin CF
Wed Jul 15 00:00:00 EDT 2009
P-glycoprotein acts as an immunomodulator during neuroinflammation.
PloS one
Kooij G,Backer R,Koning JJ,Reijerkerk A,van Horssen J,van der Pol SM,Drexhage J,Schinkel A,Dijkstra CD,den Haan JM,Geijtenbeek TB,de Vries HE
Tue Dec 08 00:00:00 EST 2009
Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner ear.
PloS one
Milo M,Cacciabue-Rivolta D,Kneebone A,Van Doorninck H,Johnson C,Lawoko-Kerali G,Niranjan M,Rivolta M,Holley M
Wed Sep 23 00:00:00 EDT 2009
Interferon-gamma targets cancer cells and osteoclasts to prevent tumor-associated bone loss and bone metastases.
The Journal of biological chemistry
Xu Z,Hurchla MA,Deng H,Uluçkan O,Bu F,Berdy A,Eagleton MC,Heller EA,Floyd DH,Dirksen WP,Shu S,Tanaka Y,Fernandez SA,Rosol TJ,Weilbaecher KN
Fri Feb 13 00:00:00 EST 2009
Trypanosome lytic factor, an antimicrobial high-density lipoprotein, ameliorates Leishmania infection.
PLoS pathogens
Samanovic M,Molina-Portela MP,Chessler AD,Burleigh BA,Raper J
315-05 was used in Cell Culture to propose that TLFs are a component of the innate immune system that can limit infections by their ability to selectively damage pathogens in phagolysosomes within the reticuloendothelial system.
Thu Jan 01 00:00:00 EST 2009
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.
Immunity
Hill JA,Hall JA,Sun CM,Cai Q,Ghyselinck N,Chambon P,Belkaid Y,Mathis D,Benoist C
Fri Nov 14 00:00:00 EST 2008
FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation.
The Journal of clinical investigation
Mancardi DA,Iannascoli B,Hoos S,England P,Daëron M,Bruhns P
Sat Nov 01 00:00:00 EDT 2008
T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice.
The Journal of clinical investigation
Jarmin SJ,David R,Ma L,Chai JG,Dewchand H,Takesono A,Ridley AJ,Okkenhaug K,Marelli-Berg FM
Sat Mar 01 00:00:00 EST 2008
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease.
The Journal of experimental medicine
Chong MM,Rasmussen JP,Rudensky AY,Littman DR
Mon Sep 01 00:00:00 EDT 2008
alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice.
Proceedings of the National Academy of Sciences of the United States of America
Lewis EC,Mizrahi M,Toledano M,Defelice N,Wright JL,Churg A,Shapiro L,Dinarello CA
Tue Oct 21 00:00:00 EDT 2008
XIAP regulates cytosol-specific innate immunity to Listeria infection.
PLoS pathogens
Bauler LD,Duckett CS,O'Riordan MX
315-05 was used in In vitro experiments to suggest that XIAP regulates innate immune responses to L. monocytogenes infection by potentiating synergy between Toll-like receptors (TLRs) and Nod-like receptors (NLRs) through activation of JNK- and NF-kappaB-dependent signaling.
Fri Aug 29 00:00:00 EDT 2008
Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK.
Journal of leukocyte biology
Rodriguez N,Lang R,Wantia N,Cirl C,Ertl T,Dürr S,Wagner H,Miethke T
315-05 was used in In vitro experiments to investigate nitrogen oxide production by innate immune cells and the role of this in defence against pathogens.
Mon Dec 01 00:00:00 EST 2008
IL-23 promotes maintenance but not commitment to the Th17 lineage.
Journal of immunology (Baltimore, Md. : 1950)
Stritesky GL,Yeh N,Kaplan MH
Sat Nov 01 00:00:00 EDT 2008
CD40 mediates retinal inflammation and neurovascular degeneration.
Journal of immunology (Baltimore, Md. : 1950)
Portillo JA,Van Grol J,Zheng L,Okenka G,Gentil K,Garland A,Carlson EC,Kern TS,Subauste CS
Mon Dec 15 00:00:00 EST 2008
IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways.
Journal of immunology (Baltimore, Md. : 1950)
Hu Y,Hu X,Boumsell L,Ivashkiv LB
Sun Jun 15 00:00:00 EDT 2008
Regulation of alternative macrophage activation by galectin-3.
Journal of immunology (Baltimore, Md. : 1950)
MacKinnon AC,Farnworth SL,Hodkinson PS,Henderson NC,Atkinson KM,Leffler H,Nilsson UJ,Haslett C,Forbes SJ,Sethi T
Fri Feb 15 00:00:00 EST 2008
Herpes virus oncolytic therapy reverses tumor immune dysfunction and facilitates tumor antigen presentation.
Cancer biology & therapy
Benencia F,Courrèges MC,Fraser NW,Coukos G
315-05 was used in Enzyme-linked immunosorbent assay to show how oncolytic HSV-1716 generates vaccination effects and that that oncolytic therapy with HSV-1716 facilitates antitumor immune responses.
Fri Aug 01 00:00:00 EDT 2008
The interferon-gamma-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3.
Cellular signalling
Harris SM,Harvey EJ,Hughes TR,Ramji DP
Mon Dec 01 00:00:00 EST 2008
Modulation of murine bone marrow-derived dendritic cells and B-cells by MCS-18 a natural product isolated from Helleborus purpurascens.
Immunobiology
Littmann L,Rössner S,Kerek F,Steinkasserer A,Zinser E
Thu Feb 05 00:00:00 EST 2009
FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.
The Journal of biological chemistry
Sanada T,Takaesu G,Mashima R,Yoshida R,Kobayashi T,Yoshimura A
Fri Dec 05 00:00:00 EST 2008
Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway.
Journal of neuroinflammation
Pais TF,Figueiredo C,Peixoto R,Braz MH,Chatterjee S
Thu Oct 09 00:00:00 EDT 2008
Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells.
Blood
Vremec D,O'Keeffe M,Hochrein H,Fuchsberger M,Caminschi I,Lahoud M,Shortman K
Thu Feb 01 00:00:00 EST 2007
Sustained release of bioactive therapeutic proteins from a biodegradable elastomeric device.
Journal of controlled release : official journal of the Controlled Release Society
Gu F,Neufeld R,Amsden B
Mon Jan 22 00:00:00 EST 2007
Induction of the formyl peptide receptor 2 in microglia by IFN-gamma and synergy with CD40 ligand.
Journal of immunology (Baltimore, Md. : 1950)
Chen K,Iribarren P,Huang J,Zhang L,Gong W,Cho EH,Lockett S,Dunlop NM,Wang JM
Thu Feb 01 00:00:00 EST 2007
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B
Sat Dec 15 00:00:00 EST 2007
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.
Blood
Mathur AN,Chang HC,Zisoulis DG,Kapur R,Belladonna ML,Kansas GS,Kaplan MH
Fri Sep 01 00:00:00 EDT 2006
Galectin-3 regulates myofibroblast activation and hepatic fibrosis.
Proceedings of the National Academy of Sciences of the United States of America
Henderson NC,Mackinnon AC,Farnworth SL,Poirier F,Russo FP,Iredale JP,Haslett C,Simpson KJ,Sethi T
Tue Mar 28 00:00:00 EST 2006
Role of immunoproteasomes in cross-presentation.
Journal of immunology (Baltimore, Md. : 1950)
Palmowski MJ,Gileadi U,Salio M,Gallimore A,Millrain M,James E,Addey C,Scott D,Dyson J,Simpson E,Cerundolo V
Sat Jul 15 00:00:00 EDT 2006
A regulatory effect of the balance between TNF-alpha and IL-6 in the granulomatous and inflammatory response to Rhodococcus aurantiacus infection in mice.
Journal of immunology (Baltimore, Md. : 1950)
Kohanawa M
Sat Jul 01 00:00:00 EDT 2006
Direct vaccination with tumor cells killed with ICP4-deficient HSVd120 elicits effective antitumor immunity.
Cancer biology & therapy
Benencia F,Courrèges MC,Conejo-García JR,Mohammed-Hadley A,Coukos G
315-05 was used in Enzyme-linked immunosorbent assay to investigate the use of replication-incompetent recombinant HSV d120 lacking immediate early gene ICP4 and HSVd120-killed tumor cells for tumor vaccination.
Sat Jul 01 00:00:00 EDT 2006
Control of infection with Leishmania major in susceptible BALB/c mice lacking the common gamma-chain for FcR is associated with reduced production of IL-10 and TGF-beta by parasitized cells.
Journal of immunology (Baltimore, Md. : 1950)
Padigel UM,Farrell JP
Sun May 15 00:00:00 EDT 2005
Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor.
The Journal of experimental medicine
Lin L,Gerth AJ,Peng SL
Mon Jul 05 00:00:00 EDT 2004
CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis.
Journal of immunology (Baltimore, Md. : 1950)
Ness TL,Carpenter KJ,Ewing JL,Gerard CJ,Hogaboam CM,Kunkel SL
Wed Dec 01 00:00:00 EST 2004
Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.
Stem cells (Dayton, Ohio)
Metcalf D,Mifsud S,Di Rago L
Wed Mar 12 00:00:00 EST 2003
Interleukin 4 and 13 participation in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation: multiparameter analysis of cellular recruitment, chemokine expression and cytokine networks.
Cytokine
Ruth JH,Warmington KS,Shang X,Lincoln P,Evanoff H,Kunkel SL,Chensue SW
Mon May 01 00:00:00 EDT 2000
