Gibco

Mouse IL-1 beta Recombinant Protein, PeproTech®

Mouse IL-1 beta Protein in Functional Assay (Functional)

FIGURE: 1 / 1

Mouse IL-1 beta Protein (211-11B-10UG) in Functional

Bioassay analysis of Mouse IL-1 beta Recombinant Protein, PeproTech® (Product # 211-11B-1MG).

Product Image Gallery

Product Details

211-11B-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

Flow Cytometry (Flow)

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

View 10 publications 10 publications

Functional Assay (Functional)

Assay-dependent

View 2 publications 2 publications

In vitro Assay (IV)

View 229 publications 229 publications

Miscellaneous PubMed (Misc)

View 39 publications 39 publications

Product Specifications

Species

Mouse

Published species

Bacteria, Hamster, Human, Mouse, Non-human primate, Rat

Expression System

E. coli

Amino acid sequence

MVPIRQLHYR LRDEQQKSLV LSDPYELKAL HLNGQNINQQ VIFSMSFVQG EPSNDKIPVA LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS

Molecular weight

17.5 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.002 ng/ml, corresponding to a specific activity of ≥ 5 x 10^8 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

211-11B-1MG will be provided as 2 x 500 µg (211-11B-500UG).

Recombinant Murine IL-1beta is a 17.5 kDa protein containing 153 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.

The Journal of experimental medicine

Krzywinska E,Sobecki M,Nagarajan S,Zacharjasz J,Tambuwala MM,Pelletier A,Cummins E,Gotthardt D,Fandrey J,Kerdiles YM,Peyssonnaux C,Taylor CT,Sexl V,Stockmann C

Mon Feb 07 00:00:00 EST 2022

Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer.

The Journal of experimental medicine

Masetti M,Carriero R,Portale F,Marelli G,Morina N,Pandini M,Iovino M,Partini B,Erreni M,Ponzetta A,Magrini E,Colombo P,Elefante G,Colombo FS,den Haan JMM,Peano C,Cibella J,Termanini A,Kunderfranco P,Brummelman J,Chung MWH,Lazzeri M,Hurle R,Casale P,Lugli E,DePinho RA,Mukhopadhyay S,Gordon S,Di Mitri D

Mon Feb 07 00:00:00 EST 2022

Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.

The Journal of experimental medicine

Ahmed N,Etzrodt M,Dettinger P,Kull T,Loeffler D,Hoppe PS,Chavez JS,Zhang Y,Camargo Ortega G,Hilsenbeck O,Nakajima H,Pietras EM,Schroeder T

Mon Jan 03 00:00:00 EST 2022

Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4.

iScience

Colombo G,Travelli C,Porta C,Genazzani AA

211-11B was used in Sample Preparation (Western Blotting) to demonstrate that eNAMPT promotes inflammation by favoring both the recruitment of myeloid cells and the induction of an inflammatory transcriptional program.

Fri Apr 15 00:00:00 EDT 2022

Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3.

Cell reports

Li Y,Zhu Y,Feng S,Ishida Y,Chiu TP,Saito T,Wang S,Ann DK,Ou JJ

211-11B was used in In vivo experiments to report that M1-like macrophages stimulated by HBV exhibit a strong HBV-suppressive effect, which is diminished in M2-like macrophages.

Tue Jan 25 00:00:00 EST 2022

Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence.

iScience

Riding AM,Loudon KW,Guo A,Ferdinand JR,Lok LSC,Richoz N,Stewart A,Castro-Dopico T,Tuong ZK,Fiancette R,Bowyer GS,Fleming A,Gillman ES,Suchanek O,Mahbubani KT,Saeb-Parsy K,Withers D,Dougan G,Clare S,Clatworthy MR

211-11B was used in Sample Preparation to provide important insights into the orchestration and execution of type 17 immunity in bladder defense.

Fri Jul 15 00:00:00 EDT 2022

NLRP3 Inflammasome Priming and Activation Are Regulated by a Phosphatidylinositol-Dependent Mechanism.

ImmunoHorizons

Hamilton C,Olona A,Leishman S,MacDonald-Ramsahai K,Cockcroft S,Larrouy-Maumus G,Anand PK

211-11B was used in In vitro experiments to reveal a novel metabolic-inflammatory circuit that contributes to calibrating immune responses.

Mon Aug 29 00:00:00 EDT 2022

Pioglitazone attenuates ischaemic stroke aggravation by blocking PPARγ reduction and inhibiting chronic inflammation in diabetic mice.

The European journal of neuroscience

Guo Y,Zuo W,Yin L,Gu T,Wang S,Fang Z,Wang B,Dong H,Hou W,Zuo Z,Deng J

211-11B was used in In vivo experiments to study whether pioglitazone use before ischaemia could reduce brain ischaemic injury.

Thu Sep 01 00:00:00 EDT 2022

The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury.

Nature communications

Bretheau F,Castellanos-Molina A,Bélanger D,Kusik M,Mailhot B,Boisvert A,Vallières N,Lessard M,Gunzer M,Liu X,Boilard É,Quan N,Lacroix S

211-11B was used in In vivo experiments to report that the alarmin interleukin (IL)-1α is produced by damaged microglia after SCI.

Sun Oct 02 00:00:00 EDT 2022

Skin-resident innate lymphoid cells converge on a pathogenic effector state.

Nature

Bielecki P,Riesenfeld SJ,Hütter JC,Torlai Triglia E,Kowalczyk MS,Ricardo-Gonzalez RR,Lian M,Amezcua Vesely MC,Kroehling L,Xu H,Slyper M,Muus C,Ludwig LS,Christian E,Tao L,Kedaigle AJ,Steach HR,York AG,Skadow MH,Yaghoubi P,Dionne D,Jarret A,McGee HM,Porter CBM,Licona-Limón P,Bailis W,Jackson R,Gagliani N,Gasteiger G,Locksley RM,Regev A,Flavell RA

211-11B was used in Sample Preparation (FC/FACS) to investigate cytokine production by tissue-resident innate lymphoid cells.

Thu Apr 01 00:00:00 EDT 2021

Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH.

Nature

Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA

211-11B was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.

Thu Apr 01 00:00:00 EDT 2021

Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH.

Nature

Thu Apr 01 00:00:00 EDT 2021

Polyamine metabolism is a central determinant of helper T cell lineage fidelity.

Cell

Puleston DJ,Baixauli F,Sanin DE,Edwards-Hicks J,Villa M,Kabat AM,Kamiński MM,Stanckzak M,Weiss HJ,Grzes KM,Piletic K,Field CS,Corrado M,Haessler F,Wang C,Musa Y,Schimmelpfennig L,Flachsmann L,Mittler G,Yosef N,Kuchroo VK,Buescher JM,Balabanov S,Pearce EJ,Green DR,Pearce EL

211-11B was used in Cell Culture to conclude that polyamine metabolism is critical for maintaining the epigenome to focus TH cell subset fidelity.

Thu Aug 05 00:00:00 EDT 2021

Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells.

Cell research

Liu C,Gong Y,Zhang H,Yang H,Zeng Y,Bian Z,Xin Q,Bai Z,Zhang M,He J,Yan J,Zhou J,Li Z,Ni Y,Wen A,Lan Y,Hu H,Liu B

Fri Oct 01 00:00:00 EDT 2021

GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair.

Immunity

Wang X,Cai J,Lin B,Ma M,Tao Y,Zhou Y,Bai L,Jiang W,Zhou R

Tue Jun 08 00:00:00 EDT 2021

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T

211-11B was used in Cell Culture to show that Linezolid, a ribosomal-targeting antibiotic (RAbo), effectively blocked the course of a T cell-mediated autoimmune disease.

Tue Jan 12 00:00:00 EST 2021

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T

211-11B was used in Cell Culture to show that Linezolid, a ribosomal-targeting antibiotic (RAbo), effectively blocked the course of a T cell-mediated autoimmune disease.

Tue Jan 12 00:00:00 EST 2021

Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease.

Immunity

Huang LJ,Mao XT,Li YY,Liu DD,Fan KQ,Liu RB,Wu TT,Wang HL,Zhang Y,Yang B,Ye CQ,Zhong JY,Chai RJ,Cao Q,Jin J

Tue Aug 10 00:00:00 EDT 2021

SPLUNC1: a novel marker of cystic fibrosis exacerbations.

The European respiratory journal

Khanal S,Webster M,Niu N,Zielonka J,Nunez M,Chupp G,Slade MD,Cohn L,Sauler M,Gomez JL,Tarran R,Sharma L,Dela Cruz CS,Egan M,Laguna T,Britto CJ

211-11B was used in Cell Culture to show that in acute CF care, low SPLUNC1 levels could support a decision to increase airway clearance or to initiate pharmacological interventions.

Mon Nov 01 00:00:00 EDT 2021

Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity.

Nature immunology

Fiancette R,Finlay CM,Willis C,Bevington SL,Soley J,Ng STH,Baker SM,Andrews S,Hepworth MR,Withers DR

Fri Oct 01 00:00:00 EDT 2021

Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.

Cellular & molecular immunology

Permanyer M,Bošnjak B,Glage S,Friedrichsen M,Floess S,Huehn J,Patzer GE,Odak I,Eckert N,Zargari R,Ospina-Quintero L,Georgiev H,Förster R

Mon Feb 01 00:00:00 EST 2021

PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress.

The Journal of experimental medicine

Chavez JS,Rabe JL,Loeffler D,Higa KC,Hernandez G,Mills TS,Ahmed N,Gessner RL,Ke Z,Idler BM,Niño KE,Kim H,Myers JR,Stevens BM,Davizon-Castillo P,Jordan CT,Nakajima H,Ashton J,Welner RS,Schroeder T,DeGregori J,Pietras EM

Mon Jun 07 00:00:00 EDT 2021

BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapy.

The Journal of experimental medicine

Pei S,Huang M,Huang J,Zhu X,Wang H,Romano S,Deng X,Wang Y,Luo Y,Hao S,Xu J,Yu T,Zhu Q,Yuan J,Shen K,Liu Z,Hu G,Peng C,Luo Q,Wen Z,Dai D,Xiao Y

Mon Jul 05 00:00:00 EDT 2021

The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.

The Journal of experimental medicine

Kiuchi M,Onodera A,Kokubo K,Ichikawa T,Morimoto Y,Kawakami E,Takayama N,Eto K,Koseki H,Hirahara K,Nakayama T

Mon Apr 05 00:00:00 EDT 2021

STING agonist promotes CAR T cell trafficking and persistence in breast cancer.

The Journal of experimental medicine

Xu N,Palmer DC,Robeson AC,Shou P,Bommiasamy H,Laurie SJ,Willis C,Dotti G,Vincent BG,Restifo NP,Serody JS

Mon Feb 01 00:00:00 EST 2021

HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis.

Proceedings of the National Academy of Sciences of the United States of America

Senda N,Yanai H,Hibino S,Li L,Mizushima Y,Miyagaki T,Saeki M,Kishi Y,Hangai S,Nishio J,Sugaya M,Taniguchi T,Sato S

Tue Jan 05 00:00:00 EST 2021

D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2α-dependent manner.

Cell proliferation

Zhou X,Zheng Y,Sun W,Zhang Z,Liu J,Yang W,Yuan W,Yi Y,Wang J,Liu J

Mon Nov 01 00:00:00 EDT 2021

Mesenchymal stromal cells expressing a dominant-negative high mobility group A1 transgene exhibit improved function during sepsis.

Journal of leukocyte biology

Kwon MY,Ghanta S,Ng J,Castano AP,Han J,Ith B,Lederer JA,El-Chemaly S,Chung SW,Liu X,Perrella MA

Fri Oct 01 00:00:00 EDT 2021

Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β.

Journal of immunology (Baltimore, Md. : 1950)

Jang YS,Song HE,Seo GY,Jo HJ,Park S,Park HW,Kim TG,Kang SG,Yoon SI,Ko HJ,Lee GS,Park SR,Kim PH

Mon Nov 15 00:00:00 EST 2021

Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Wang W,Qin Y,Song H,Wang L,Jia M,Zhao C,Gong M,Zhao W

Tue Jun 01 00:00:00 EDT 2021

Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2'3'-Cyclic GMP-AMP and Cisplatin under Steady State and Inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Chen X,Wang L,Cao L,Li T,Li Z,Sun Y,Ding J,Zhou C,Xie Y,Yue N,Nan J,Jia XM,Peng C,Li H,Yang J,Xiao H

Sat May 01 00:00:00 EDT 2021

VEGF Contributes to Mesenchymal Stem Cell-Mediated Reversion of Nor1-Dependent Hypertrophy in iPS Cell-Derived Cardiomyocytes.

Stem cells international

Philipp D,Holthaus M,Basoah V,Pfannkuche K,Suhr L,Wahlers T,Paunel-Görgülü A

Sun May 02 00:00:00 EDT 2021

The Antioxidant Resveratrol Protects against Chondrocyte Apoptosis by Regulating the COX-2/NF-κB Pathway in Created Temporomandibular Osteoarthritis.

BioMed research international

Li W,Hu S,Chen X,Shi J

Wed Sep 22 00:00:00 EDT 2021

Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF.

Cell death & disease

Buffolo F,Petrosino V,Albini M,Moschetta M,Carlini F,Floss T,Kerlero de Rosbo N,Cesca F,Rocchi A,Uccelli A,Benfenati F

Mon Feb 15 00:00:00 EST 2021

Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy.

Nature communications

Bian Z,Shi L,Kidder K,Zen K,Garnett-Benson C,Liu Y

Fri May 28 00:00:00 EDT 2021

Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration.

Cell reports

Marks KE,Flaherty S,Patterson KM,Stratton M,Martinez GJ,Reynolds JM

Tue Jun 29 00:00:00 EDT 2021

Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro.

Redox biology

Pescador N,Francisco V,Vázquez P,Esquinas EM,González-Páramos C,Valdecantos MP,García-Martínez I,Urrutia AA,Ruiz L,Escalona-Garrido C,Foretz M,Viollet B,Fernández-Moreno MÁ,Calle-Pascual AL,Obregón MJ,Aragonés J,Valverde ÁM

211-11B was used in Cell Culture to find the impact of metformin on macrophages by suppressing a HIF1α-dependent proinflammatory program is likely responsible for a secondary beneficial effect on insulin-mediated glucose uptake and β-adrenergic responses in brown adipocytes.

Tue Oct 19 00:00:00 EDT 2021

TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.

Nature communications

Yabe R,Chung SH,Murayama MA,Kubo S,Shimizu K,Akahori Y,Maruhashi T,Seno A,Kaifu T,Saijo S,Iwakura Y

Mon Jan 04 00:00:00 EST 2021

RORα is critical for mTORC1 activity in T cell-mediated colitis.

Cell reports

Chi X,Jin W,Bai X,Zhao X,Shao J,Li J,Sun Q,Su B,Wang X,Yang XO,Dong C

Tue Sep 14 00:00:00 EDT 2021

Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals.

Nature communications

Tao H,Pan Y,Chu S,Li L,Xie J,Wang P,Zhang S,Reddy S,Sleasman JW,Zhong XP

211-11B was used in In vivo experiments to demonstrate that IL-2/IL-15 receptor β chain and inducible costimulatory (ICOS) not only serve as lineage-specific markers for IFN-γ-producing MAIT1 and IL-17A-producing MAIT17 cells, but are also important for their differentiation, respectively.

Thu Apr 01 00:00:00 EDT 2021

Interleukin-37 regulates innate immune signaling in human and mouse colonic organoids.

Scientific reports

Allaire JM,Poon A,Crowley SM,Han X,Sharafian Z,Moore N,Stahl M,Bressler B,Lavoie PM,Jacobson K,Li X,Vallance BA

Thu Apr 15 00:00:00 EDT 2021

Phagocytosis of microparticles increases responsiveness of macrophage-like cell lines U937 and THP-1 to bacterial lipopolysaccharide and lipopeptide.

Scientific reports

Ueno T,Yamamoto Y,Kawasaki K

Wed Mar 24 00:00:00 EDT 2021

The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation.

Immunity

Chang D,Xing Q,Su Y,Zhao X,Xu W,Wang X,Dong C

Tue Sep 15 00:00:00 EDT 2020

In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors.

Immunity

Zeis P,Lian M,Fan X,Herman JS,Hernandez DC,Gentek R,Elias S,Symowski C,Knöpper K,Peltokangas N,Friedrich C,Doucet-Ladeveze R,Kabat AM,Locksley RM,Voehringer D,Bajenoff M,Rudensky AY,Romagnani C,Grün D,Gasteiger G

Tue Oct 13 00:00:00 EDT 2020

Aging-induced IL27Ra signaling impairs hematopoietic stem cells.

Blood

He H,Xu P,Zhang X,Liao M,Dong Q,Cong T,Tang B,Yang X,Ye M,Chang Y,Liu W,Wang X,Ju Z,Wang J

Thu Jul 09 00:00:00 EDT 2020

JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.

Blood

Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE

Thu Aug 06 00:00:00 EDT 2020

Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments.

The Journal of clinical investigation

Matthias J,Heink S,Picard F,Zeiträg J,Kolz A,Chao YY,Soll D,de Almeida GP,Glasmacher E,Jacobsen ID,Riedel T,Peters A,Floess S,Huehn J,Baumjohann D,Huber M,Korn T,Zielinski CE

Tue Sep 01 00:00:00 EDT 2020

Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.

The Journal of clinical investigation

Hyun J,Sun Z,Ahmadi AR,Bangru S,Chembazhi UV,Du K,Chen T,Tsukamoto H,Rusyn I,Kalsotra A,Diehl AM

Wed Apr 01 00:00:00 EDT 2020

Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain.

The Journal of experimental medicine

Bogie JFJ,Grajchen E,Wouters E,Corrales AG,Dierckx T,Vanherle S,Mailleux J,Gervois P,Wolfs E,Dehairs J,Van Broeckhoven J,Bowman AP,Lambrichts I,Gustafsson JÅ,Remaley AT,Mulder M,Swinnen JV,Haidar M,Ellis SR,Ntambi JM,Zelcer N,Hendriks JJA

Mon May 04 00:00:00 EDT 2020

Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation.

The Journal of experimental medicine

Gao Y,Deason K,Jain A,Irizarry-Caro RA,Dozmorov I,Coughlin LA,Rauch I,Evers BM,Koh AY,Wakeland EK,Pasare C

Mon Apr 06 00:00:00 EDT 2020

STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells.

EMBO molecular medicine

Kahlfuss S,Kaufmann U,Concepcion AR,Noyer L,Raphael D,Vaeth M,Yang J,Pancholi P,Maus M,Muller J,Kozhaya L,Khodadadi-Jamayran A,Sun Z,Shaw P,Unutmaz D,Stathopulos PB,Feist C,Cameron SB,Turvey SE,Feske S

Fri Aug 07 00:00:00 EDT 2020

Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α-dependent pathways.

Proceedings of the National Academy of Sciences of the United States of America

Morianos I,Trochoutsou AI,Papadopoulou G,Semitekolou M,Banos A,Konstantopoulos D,Manousopoulou A,Kapasa M,Wei P,Lomenick B,Belaidi E,Kalamatas T,Karageorgiou K,Doskas T,Sallusto F,Pan F,Garbis SD,Quintana FJ,Xanthou G

Tue Jun 02 00:00:00 EDT 2020

Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α.

Journal of immunology (Baltimore, Md. : 1950)

Martin P,Palmer G,Rodriguez E,Palomo J,Lemeille S,Goldstein J,Gabay C

Sat Feb 15 00:00:00 EST 2020

Calcitriol Regulates the Differentiation of IL-9-Secreting Th9 Cells by Modulating the Transcription Factor PU.1.

Journal of immunology (Baltimore, Md. : 1950)

Vyas SP,Hansda AK,Kaplan MH,Goswami R

Sun Mar 01 00:00:00 EST 2020

Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.

Journal of immunology (Baltimore, Md. : 1950)

Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D

Thu Oct 15 00:00:00 EDT 2020

Myeloid Cell-Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions.

Journal of immunology (Baltimore, Md. : 1950)

Yan J,Hedl M,Abraham C

Sat Aug 15 00:00:00 EDT 2020

TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating T_H1/T_H17 Cell Response.

Journal of immunology (Baltimore, Md. : 1950)

Yi FS,Zhang X,Zhai K,Huang ZY,Wu XZ,Wu MT,Shi XY,Pei XB,Dong SF,Wang W,Yang Y,Du J,Luo ZT,Shi HZ

Sun Nov 15 00:00:00 EST 2020

Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism.

American journal of physiology. Cell physiology

Liu F,Wang X,Geng H,Bu HF,Wang P,De Plaen IG,Yang H,Qian J,Tan XD

Wed Apr 01 00:00:00 EDT 2020

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs.

Nature communications

Pein M,Insua-Rodríguez J,Hongu T,Riedel A,Meier J,Wiedmann L,Decker K,Essers MAG,Sinn HP,Spaich S,Sütterlin M,Schneeweiss A,Trumpp A,Oskarsson T

Fri Mar 20 00:00:00 EDT 2020

Maternal administration of probiotics promotes brain development and protects offspring's brain from postnatal inflammatory insults in C57/BL6J mice.

Scientific reports

Lu J,Lu L,Yu Y,Baranowski J,Claud EC

Mon May 18 00:00:00 EDT 2020

CD4⁺ T-Cell Differentiation In Vitro.

Methods in molecular biology (Clifton, N.J.)

Yang W,Chen X,Hu H

211-11B was used in In vitro experiments to study the regulating mechanism and function of Th cells, dependent on in vitro CD4+ T-cell differentiation.

Tue Jan 26 00:00:00 EST 2021

Quantification of Citrullinated Histone H3 Bound DNA for Detection of Neutrophil Extracellular Traps.

Cancers

Li M,Lin C,Leso A,Nefedova Y

211-11B was used in In vitro experiments to investigate NET formation in cancer.

Wed Nov 18 00:00:00 EST 2020

Low-intensity pulsed ultrasound inhibits VEGFA expression in chondrocytes and protects against cartilage degeneration in experimental osteoarthritis.

FEBS open bio

Guan M,Zhu Y,Liao B,Tan Q,Qi H,Zhang B,Huang J,Du X,Bai D

Sun Mar 01 00:00:00 EST 2020

LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis.

Nature communications

Arra M,Swarnkar G,Ke K,Otero JE,Ying J,Duan X,Maruyama T,Rai MF,O'Keefe RJ,Mbalaviele G,Shen J,Abu-Amer Y

Thu Jul 09 00:00:00 EDT 2020

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.

Nature communications

Mayr L,Grabherr F,Schwärzler J,Reitmeier I,Sommer F,Gehmacher T,Niederreiter L,He GW,Ruder B,Kunz KTR,Tymoszuk P,Hilbe R,Haschka D,Feistritzer C,Gerner RR,Enrich B,Przysiecki N,Seifert M,Keller MA,Oberhuber G,Sprung S,Ran Q,Koch R,Effenberger M,Tancevski I,Zoller H,Moschen AR,Weiss G,Becker C,Rosenstiel P,Kaser A,Tilg H,Adolph TE

Tue Apr 14 00:00:00 EDT 2020

Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor.

Scientific reports

Rambousek L,Gschwind T,Lafourcade C,Paterna JC,Dib L,Fritschy JM,Fontana A

Fri Feb 28 00:00:00 EST 2020

Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice.

Scientific reports

Wang J,Ortiz C,Fontenot L,Mukhopadhyay R,Xie Y,Law IKM,Shih DQ,Mattai SA,Li Z,Koon HW

Thu Jul 30 00:00:00 EDT 2020

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.

Cell

Brown CC,Gudjonson H,Pritykin Y,Deep D,Lavallée VP,Mendoza A,Fromme R,Mazutis L,Ariyan C,Leslie C,Pe'er D,Rudensky AY

Thu Oct 31 00:00:00 EDT 2019

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.

Cell

Mogilenko DA,Haas JT,L'homme L,Fleury S,Quemener S,Levavasseur M,Becquart C,Wartelle J,Bogomolova A,Pineau L,Molendi-Coste O,Lancel S,Dehondt H,Gheeraert C,Melchior A,Dewas C,Nikitin A,Pic S,Rabhi N,Annicotte JS,Oyadomari S,Velasco-Hernandez T,Cammenga J,Foretz M,Viollet B,Vukovic M,Villacreces A,Kranc K,Carmeliet P,Marot G,Boulter A,Tavernier S,Berod L,Longhi MP,Paget C,Janssens S,Staumont-Sallé D,Aksoy E,Staels B,Dombrowicz D

Thu May 16 00:00:00 EDT 2019

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin.

Immunity

Burzynski LC,Humphry M,Pyrillou K,Wiggins KA,Chan JNE,Figg N,Kitt LL,Summers C,Tatham KC,Martin PB,Bennett MR,Clarke MCH

Tue Apr 16 00:00:00 EDT 2019

Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β.

Immunity

Komuczki J,Tuzlak S,Friebel E,Hartwig T,Spath S,Rosenstiel P,Waisman A,Opitz L,Oukka M,Schreiner B,Pelczar P,Becher B

Tue May 21 00:00:00 EDT 2019

Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.

Immunity

Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI

Tue Jan 15 00:00:00 EST 2019

Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.

Nature immunology

Cella M,Gamini R,Sécca C,Collins PL,Zhao S,Peng V,Robinette ML,Schettini J,Zaitsev K,Gordon W,Bando JK,Yomogida K,Cortez V,Fronick C,Fulton R,Lin LL,Gilfillan S,Flavell RA,Shan L,Artyomov MN,Bowman M,Oltz EM,Jelinsky SA,Colonna M

211-11B was used in Flow cytometry/Cell sorting to demonstrate that innate lymphoid cells (ILCs) undergo conversion from ILC3s into ILC1-like cells in human tissues in vivo, requiring tissue factors and Aiolos in the process.

Thu Aug 01 00:00:00 EDT 2019

A role for macrophages in hematopoiesis in the embryonic head.

Blood

Li Z,Mariani SA,Rodriguez-Seoane C,He W,Ning X,Liu B,Vink CS,Dzierzak E

Thu Nov 28 00:00:00 EST 2019

Type I interferon induces CXCL13 to support ectopic germinal center formation.

The Journal of experimental medicine

Denton AE,Innocentin S,Carr EJ,Bradford BM,Lafouresse F,Mabbott NA,Mörbe U,Ludewig B,Groom JR,Good-Jacobson KL,Linterman MA

Mon Mar 04 00:00:00 EST 2019

TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.

The Journal of experimental medicine

Sun X,Cui Y,Feng H,Liu H,Liu X

Mon Dec 02 00:00:00 EST 2019

Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin.

The EMBO journal

Fossati G,Pozzi D,Canzi A,Mirabella F,Valentino S,Morini R,Ghirardini E,Filipello F,Moretti M,Gotti C,Annis DS,Mosher DF,Garlanda C,Bottazzi B,Taraboletti G,Mantovani A,Matteoli M,Menna E

Thu Jan 03 00:00:00 EST 2019

Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset.

Aging cell

Martini H,Iacovoni JS,Maggiorani D,Dutaur M,Marsal DJ,Roncalli J,Itier R,Dambrin C,Pizzinat N,Mialet-Perez J,Cussac D,Parini A,Lefevre L,Douin-Echinard V

Tue Oct 01 00:00:00 EDT 2019

Leveraging chromatin accessibility for transcriptional regulatory network inference in T Helper 17 Cells.

Genome research

Miraldi ER,Pokrovskii M,Watters A,Castro DM,De Veaux N,Hall JA,Lee JY,Ciofani M,Madar A,Carriero N,Littman DR,Bonneau R

211-11B was used in Sample Preparation to study TRN inference in a mammalian setting by developing methods in the context of T Helper Cell Type 17 (Th17) differentiation, generating new ATAC-seq data to complement existing Th17 genomic resources. This study provides quantitative, genome-scale evaluation of TRN inference, combining ATAC-seq and RNA-seq data.

Fri Mar 01 00:00:00 EST 2019

Astrocytes in juvenile neuronal ceroid lipofuscinosis (CLN3) display metabolic and calcium signaling abnormalities.

Journal of neurochemistry

Bosch ME,Kielian T

211-11B was used in Cell Culture to investigate astrocyte glutamate toxicity in neuronal loss of juvenile neuronal ceroid lipofuscinosis.

Fri Mar 01 00:00:00 EST 2019

USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1.

Journal of immunology (Baltimore, Md. : 1950)

Lei CQ,Wu X,Zhong X,Jiang L,Zhong B,Shu HB

211-11B was used in In vitro experiments to investigate ubiquitination of TAK1.

Mon Jul 01 00:00:00 EDT 2019

USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1.

Journal of immunology (Baltimore, Md. : 1950)

Lei CQ,Wu X,Zhong X,Jiang L,Zhong B,Shu HB

211-11B was used in In vitro experiments to investigate ubiquitination of TAK1.

Mon Jul 01 00:00:00 EDT 2019

Skin Wounding-Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency.

Journal of immunology (Baltimore, Md. : 1950)

Barman PK,Pang J,Urao N,Koh TJ

211-11B was used in Cell Culture to investigate whether skin wounding induces monocyte expansion in bone marrow and if IL-1R1 signalling regulates this process.

Wed May 01 00:00:00 EDT 2019

Gamma-secretase inhibitor suppressed Notch1 intracellular domain combination with p65 and resulted in the inhibition of the NF-κB signaling pathway induced by IL-1β and TNF-α in nucleus pulposus cells.

Journal of cellular biochemistry

Huang Y,Mei W,Chen J,Jiang T,Zhou Z,Yin G,Fan J

Fri Feb 01 00:00:00 EST 2019

Journal of cellular biochemistry

Huang Y,Mei W,Chen J,Jiang T,Zhou Z,Yin G,Fan J

Fri Feb 01 00:00:00 EST 2019

Intravitreal injection of adenosine A_2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice.

Scientific reports

Aires ID,Madeira MH,Boia R,Rodrigues-Neves AC,Martins JM,Ambrósio AF,Santiago AR

Wed Nov 20 00:00:00 EST 2019

Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation.

Scientific reports

Dai D,Yuan J,Wang Y,Xu J,Mao C,Xiao Y

Wed May 29 00:00:00 EDT 2019

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.

Nature communications

Rosenbaum M,Gewies A,Pechloff K,Heuser C,Engleitner T,Gehring T,Hartjes L,Krebs S,Krappmann D,Kriegsmann M,Weichert W,Rad R,Kurts C,Ruland J

Tue May 28 00:00:00 EDT 2019

Single-cell RNA-Seq analysis identifies a noncoding interleukin 4 (IL-4) RNA that post-transcriptionally up-regulates IL-4 production in T helper cells.

The Journal of biological chemistry

Yin W,Song Y,Chang X

Fri Jan 04 00:00:00 EST 2019

Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis.

Cell reports

Koliaraki V,Chalkidi N,Henriques A,Tzaferis C,Polykratis A,Waisman A,Muller W,Hackam DJ,Pasparakis M,Kollias G

211-11B was used in Cell Culture to investigate the role of MyD88 in sporadic intestinal carcinogenesis.

Tue Jan 15 00:00:00 EST 2019

c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.

Nature

Xu M,Pokrovskii M,Ding Y,Yi R,Au C,Harrison OJ,Galan C,Belkaid Y,Bonneau R,Littman DR

Thu Feb 15 00:00:00 EST 2018

Vitamin D Switches BAF Complexes to Protect β Cells.

Cell

Wei Z,Yoshihara E,He N,Hah N,Fan W,Pinto AFM,Huddy T,Wang Y,Ross B,Estepa G,Dai Y,Ding N,Sherman MH,Fang S,Zhao X,Liddle C,Atkins AR,Yu RT,Downes M,Evans RM

Thu May 17 00:00:00 EDT 2018

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Cell

Mitroulis I,Ruppova K,Wang B,Chen LS,Grzybek M,Grinenko T,Eugster A,Troullinaki M,Palladini A,Kourtzelis I,Chatzigeorgiou A,Schlitzer A,Beyer M,Joosten LAB,Isermann B,Lesche M,Petzold A,Simons K,Henry I,Dahl A,Schultze JL,Wielockx B,Zamboni N,Mirtschink P,Coskun Ü,Hajishengallis G,Netea MG,Chavakis T

Thu Jan 11 00:00:00 EST 2018

Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.

Cell

Barrow AD,Edeling MA,Trifonov V,Luo J,Goyal P,Bohl B,Bando JK,Kim AH,Walker J,Andahazy M,Bugatti M,Melocchi L,Vermi W,Fremont DH,Cox S,Cella M,Schmedt C,Colonna M

Thu Jan 25 00:00:00 EST 2018

T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.

Immunity

Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W

Tue Apr 17 00:00:00 EDT 2018

Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses.

Immunity

Barbet G,Sander LE,Geswell M,Leonardi I,Cerutti A,Iliev I,Blander JM

Tue Mar 20 00:00:00 EDT 2018

Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.

Immunity

Wang Z,Yin W,Zhu L,Li J,Yao Y,Chen F,Sun M,Zhang J,Shen N,Song Y,Chang X

Tue Jul 17 00:00:00 EDT 2018

Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis.

Immunity

Castellanos JG,Woo V,Viladomiu M,Putzel G,Lima S,Diehl GE,Marderstein AR,Gandara J,Perez AR,Withers DR,Targan SR,Shih DQ,Scherl EJ,Longman RS

Tue Dec 18 00:00:00 EST 2018

OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling.

Molecular cell

Zhao Y,Mudge MC,Soll JM,Rodrigues RB,Byrum AK,Schwarzkopf EA,Bradstreet TR,Gygi SP,Edelson BT,Mosammaparast N

211-11B was used in In vitro experiments to study how the deubiquitinase OTUD4, which nominally encodes a K48-specific deubiquitinase, is phosphorylated near its catalytic domain, activating a latent K63-specific deubiquitinase to show how deubiquitinase may modulate diverse processes through post-translational modification.

Thu Feb 01 00:00:00 EST 2018

BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation.

The Journal of experimental medicine

Deason K,Troutman TD,Jain A,Challa DK,Mandraju R,Brewer T,Ward ES,Pasare C

Mon Sep 03 00:00:00 EDT 2018

RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions.

The Journal of experimental medicine

Hogstad B,Berres ML,Chakraborty R,Tang J,Bigenwald C,Serasinghe M,Lim KPH,Lin H,Man TK,Remark R,Baxter S,Kana V,Jordan S,Karoulia Z,Kwan WH,Leboeuf M,Brandt E,Salmon H,McClain K,Poulikakos P,Chipuk J,Mulder WJM,Allen CE,Merad M

Tue Jan 02 00:00:00 EST 2018

The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination.

The Journal of experimental medicine

Yu F,Sharma S,Jankovic D,Gurram RK,Su P,Hu G,Li R,Rieder S,Zhao K,Sun B,Zhu J

Mon Jul 02 00:00:00 EDT 2018

Contextual control of skin immunity and inflammation by Corynebacterium.

The Journal of experimental medicine

Ridaura VK,Bouladoux N,Claesen J,Chen YE,Byrd AL,Constantinides MG,Merrill ED,Tamoutounour S,Fischbach MA,Belkaid Y

Mon Mar 05 00:00:00 EST 2018

Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling.

Experimental & molecular medicine

Baek JM,Cheon YH,Kwak SC,Jun HY,Yoon KH,Lee MS,Kim JY

Fri Apr 27 00:00:00 EDT 2018

IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.

Journal of immunology (Baltimore, Md. : 1950)

Hashiguchi Y,Yabe R,Chung SH,Murayama MA,Yoshida K,Matsuo K,Kubo S,Saijo S,Nakamura Y,Matsue H,Iwakura Y

Sun Jul 01 00:00:00 EDT 2018

Single cell analysis of kynurenine and System L amino acid transport in T cells.

Nature communications

Sinclair LV,Neyens D,Ramsay G,Taylor PM,Cantrell DA

Thu May 17 00:00:00 EDT 2018

GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice.

Scientific reports

Chen C,Li X,Ge G,Liu J,Biju KC,Laing SD,Qian Y,Ballard C,He Z,Masliah E,Clark RA,O'Connor JC,Li S

Tue Apr 03 00:00:00 EDT 2018

Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.

Frontiers in pharmacology

Liang S,Lv ZT,Zhang JM,Wang YT,Dong YH,Wang ZG,Chen K,Cheng P,Yang Q,Guo FJ,Lu WW,Zhu WT,Chen AM

211-11B was used in In vitro experiments to study the effects of necrostatin-1 (Nec-1) on interleukin (IL)-1β-induced inflammation in mouse chondrocytes and the destabilised medial meniscus (DMM) mouse model.

Tue Sep 29 00:00:00 EDT 2020

Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint.

The Journal of biological chemistry

Wang Z,Huang J,Zhou S,Luo F,Tan Q,Sun X,Ni Z,Chen H,Du X,Xie Y,Chen L

Fri Jun 08 00:00:00 EDT 2018

Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28.

Nature communications

Jiang Y,Liu Y,Lu H,Sun SC,Jin W,Wang X,Dong C

Thu Apr 12 00:00:00 EDT 2018

Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent M2b polarization.

Stem cell research & therapy

Philipp D,Suhr L,Wahlers T,Choi YH,Paunel-Görgülü A

Thu Oct 25 00:00:00 EDT 2018

Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment.

Cell death & disease

Ruiz L,Gurlo T,Ravier MA,Wojtusciszyn A,Mathieu J,Brown MR,Broca C,Bertrand G,Butler PC,Matveyenko AV,Dalle S,Costes S

Tue May 22 00:00:00 EDT 2018

Inflammatory memory sensitizes skin epithelial stem cells to tissue damage.

Nature

Naik S,Larsen SB,Gomez NC,Alaverdyan K,Sendoel A,Yuan S,Polak L,Kulukian A,Chai S,Fuchs E

Thu Oct 26 00:00:00 EDT 2017

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.

Nature

Molgora M,Bonavita E,Ponzetta A,Riva F,Barbagallo M,Jaillon S,Popović B,Bernardini G,Magrini E,Gianni F,Zelenay S,Jonjić S,Santoni A,Garlanda C,Mantovani A

Thu Nov 02 00:00:00 EDT 2017

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.

Cell

Moretti J,Roy S,Bozec D,Martinez J,Chapman JR,Ueberheide B,Lamming DW,Chen ZJ,Horng T,Yeretssian G,Green DR,Blander JM

Thu Nov 02 00:00:00 EDT 2017

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.

Cell

Dang EV,McDonald JG,Russell DW,Cyster JG

Thu Nov 16 00:00:00 EST 2017

Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4⁺ T Cell Dysfunction.

Immunity

Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W

Tue Dec 19 00:00:00 EST 2017

IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance.

Cell host & microbe

Tsai PY,Zhang B,He WQ,Zha JM,Odenwald MA,Singh G,Tamura A,Shen L,Sailer A,Yeruva S,Kuo WT,Fu YX,Tsukita S,Turner JR

211-11B was used in Cell Culture to investigate the pathogenic effects of diarrhea.

Wed Jun 14 00:00:00 EDT 2017

The islet-resident macrophage is in an inflammatory state and senses microbial products in blood.

The Journal of experimental medicine

Ferris ST,Zakharov PN,Wan X,Calderon B,Artyomov MN,Unanue ER,Carrero JA

Mon Aug 07 00:00:00 EDT 2017

Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling-Induced Nontranscriptional Priming of the NLRP3 Inflammasome.

Journal of immunology (Baltimore, Md. : 1950)

Xing Y,Yao X,Li H,Xue G,Guo Q,Yang G,An L,Zhang Y,Meng G

Fri Sep 01 00:00:00 EDT 2017

IL-2 Shapes the Survival and Plasticity of IL-17-Producing γδ T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Corpuz TM,Vazquez-Lombardi R,Luong JK,Warren J,Stolp J,Christ D,King C,Brink R,Sprent J,Webster KE

Sun Oct 01 00:00:00 EDT 2017

Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors.

Journal of immunology (Baltimore, Md. : 1950)

Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Hayashi T,Nakachi K,Moore MA,van den Brink MRM,Kusunoki Y

Sun Oct 15 00:00:00 EDT 2017

Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages.

Oncoimmunology

Kersten K,Coffelt SB,Hoogstraat M,Verstegen NJM,Vrijland K,Ciampricotti M,Doornebal CW,Hau CS,Wellenstein MD,Salvagno C,Doshi P,Lips EH,Wessels LFA,de Visser KE

211-11B was used in In vivo experiments to demonstrate mammary tumor-derived CCL2 can facilitate the breast cancer-induced pro-metastatic systemic inflammatory gamma delta T cell-IL17-neutrophil axis.

Sat Jan 29 00:00:00 EST 2022

Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.

NPJ Parkinson's disease

Sarkar S,Malovic E,Harishchandra DS,Ghaisas S,Panicker N,Charli A,Palanisamy BN,Rokad D,Jin H,Anantharam V,Kanthasamy A,Kanthasamy AG

Wed Sep 30 00:00:00 EDT 2020

A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage.

Scientific reports

Zhang J,Li K,Yuan M,Zhang J,Huang G,Ao J,Tan H,Li Y,Gong D,Li J,Kang L,An N,Li F,Lin P,Huang L

211-11B was used in Cell Culture to investigate a high-fat diet in mice on Interleukin 1 beta.

Mon Apr 03 00:00:00 EDT 2017

Implication of REDD1 in the activation of inflammatory pathways.

Scientific reports

Pastor F,Dumas K,Barthélémy MA,Regazzetti C,Druelle N,Peraldi P,Cormont M,Tanti JF,Giorgetti-Peraldi S

Tue Aug 01 00:00:00 EDT 2017

IL-15 sustains IL-7R-independent ILC2 and ILC3 development.

Nature communications

Robinette ML,Bando JK,Song W,Ulland TK,Gilfillan S,Colonna M

Fri Mar 31 00:00:00 EDT 2017

The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.

Oncoimmunology

Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M

211-11B was used in Cell Culture to genetically investigate the role of the interleukin-1 receptor 1 pathway in breast cancer tumourigenesis and metastasis using a mouse model.

Tue Jan 12 00:00:00 EST 2021

The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction.

Scientific reports

Nagasaka A,Mogi C,Ono H,Nishi T,Horii Y,Ohba Y,Sato K,Nakaya M,Okajima F,Kurose H

Thu Aug 10 00:00:00 EDT 2017

The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes-associated osteoarthritis.

The Journal of biological chemistry

Vaamonde-Garcia C,Courties A,Pigenet A,Laiguillon MC,Sautet A,Houard X,Kerdine-Römer S,Meijide R,Berenbaum F,Sellam J

Fri Sep 01 00:00:00 EDT 2017

DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.

Cell

Herrtwich L,Nanda I,Evangelou K,Nikolova T,Horn V,Erny D,Stefanowski J,Rogell L,Klein C,Gharun K,Follo M,Seidl M,Kremer B,Münke N,Senges J,Fliegauf M,Aschman T,Pfeifer D,Sarrazin S,Sieweke MH,Wagner D,Dierks C,Haaf T,Ness T,Zaiss MM,Voll RE,Deshmukh SD,Prinz M,Goldmann T,Hölscher C,Hauser AE,Lopez-Contreras AJ,Grün D,Gorgoulis V,Diefenbach A,Henneke P,Triantafyllopoulou A

Thu Nov 17 00:00:00 EST 2016

The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression.

Immunity

Ichiyama K,Gonzalez-Martin A,Kim BS,Jin HY,Jin W,Xu W,Sabouri-Ghomi M,Xu S,Zheng P,Xiao C,Dong C

Tue Jun 21 00:00:00 EDT 2016

Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.

Immunity

Bhattacharya N,Yuan R,Prestwood TR,Penny HL,DiMaio MA,Reticker-Flynn NE,Krois CR,Kenkel JA,Pham TD,Carmi Y,Tolentino L,Choi O,Hulett R,Wang J,Winer DA,Napoli JL,Engleman EG

Tue Sep 20 00:00:00 EDT 2016

Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation.

Immunity

Woytschak J,Keller N,Krieg C,Impellizzieri D,Thompson RW,Wynn TA,Zinkernagel AS,Boyman O

Tue Jul 19 00:00:00 EDT 2016

Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.

The Journal of clinical investigation

Fritz M,Klawonn AM,Nilsson A,Singh AK,Zajdel J,Wilhelms DB,Lazarus M,Löfberg A,Jaarola M,Kugelberg UÖ,Billiar TR,Hackam DJ,Sodhi CP,Breyer MD,Jakobsson J,Schwaninger M,Schütz G,Parkitna JR,Saper CB,Blomqvist A,Engblom D

Mon Feb 01 00:00:00 EST 2016

Donor dendritic cell-derived exosomes promote allograft-targeting immune response.

The Journal of clinical investigation

Liu Q,Rojas-Canales DM,Divito SJ,Shufesky WJ,Stolz DB,Erdos G,Sullivan ML,Gibson GA,Watkins SC,Larregina AT,Morelli AE

Mon Aug 01 00:00:00 EDT 2016

Recent thymic emigrants are tolerized in the absence of inflammation.

The Journal of experimental medicine

Friesen TJ,Ji Q,Fink PJ

Mon May 30 00:00:00 EDT 2016

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis.

The Journal of experimental medicine

Littlewood-Evans A,Sarret S,Apfel V,Loesle P,Dawson J,Zhang J,Muller A,Tigani B,Kneuer R,Patel S,Valeaux S,Gommermann N,Rubic-Schneider T,Junt T,Carballido JM

Mon Aug 22 00:00:00 EDT 2016

Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa.

Proceedings of the National Academy of Sciences of the United States of America

Oh JE,Kim BC,Chang DH,Kwon M,Lee SY,Kang D,Kim JY,Hwang I,Yu JW,Nakae S,Lee HK

Tue Feb 09 00:00:00 EST 2016

Differentiation of Vascular Stem Cells Contributes to Ectopic Calcification of Atherosclerotic Plaque.

Stem cells (Dayton, Ohio)

Leszczynska A,O'Doherty A,Farrell E,Pindjakova J,O'Brien FJ,O'Brien T,Barry F,Murphy M

Fri Apr 01 00:00:00 EDT 2016

Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection.

Journal of immunology (Baltimore, Md. : 1950)

Marinho FV,Fahel JS,Scanga CA,Gomes MT,Guimarães G,Carvalho GR,Morales SV,Báfica A,Oliveira SC

Thu Sep 01 00:00:00 EDT 2016

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.

Journal of immunology (Baltimore, Md. : 1950)

Barros-Martins J,Schmolka N,Fontinha D,Pires de Miranda M,Simas JP,Brok I,Ferreira C,Veldhoen M,Silva-Santos B,Serre K

Sun May 01 00:00:00 EDT 2016

The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development.

Journal of immunology (Baltimore, Md. : 1950)

Koh B,Hufford MM,Pham D,Olson MR,Wu T,Jabeen R,Sun X,Kaplan MH

Thu Sep 15 00:00:00 EDT 2016

Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Su P,Chen S,Zheng YH,Zhou HY,Yan CH,Yu F,Zhang YG,He L,Zhang Y,Wang Y,Wu L,Wu X,Yu B,Ma LY,Yang Z,Wang J,Zhao G,Zhu J,Wu ZY,Sun B

Mon Aug 15 00:00:00 EDT 2016

Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice.

Journal of immunology (Baltimore, Md. : 1950)

Niu S,Bian Z,Tremblay A,Luo Y,Kidder K,Mansour A,Zen K,Liu Y

Sat Oct 15 00:00:00 EDT 2016

Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.

Journal of immunology (Baltimore, Md. : 1950)

Sood S,Brownlie RJ,Garcia C,Cowan G,Salmond RJ,Sakaguchi S,Zamoyska R

Fri Jul 15 00:00:00 EDT 2016

β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage.

Journal of immunology (Baltimore, Md. : 1950)

Boucard-Jourdin M,Kugler D,Endale Ahanda ML,This S,De Calisto J,Zhang A,Mora JR,Stuart LM,Savill J,Lacy-Hulbert A,Paidassi H

Thu Sep 01 00:00:00 EDT 2016

Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis.

Journal of immunology (Baltimore, Md. : 1950)

Matsumura K,Iwai H,Kato-Miyazawa M,Kirikae F,Zhao J,Yanagawa T,Ishii T,Miyoshi-Akiyama T,Funatogawa K,Kirikae T

Sat Oct 15 00:00:00 EDT 2016

Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.

Nature communications

O'Leary CE,Riling CR,Spruce LA,Ding H,Kumar S,Deng G,Liu Y,Seeholzer SH,Oliver PM

Mon Apr 18 00:00:00 EDT 2016

Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis.

Scientific reports

Liu J,Copland DA,Theodoropoulou S,Chiu HA,Barba MD,Mak KW,Mack M,Nicholson LB,Dick AD

Fri Feb 05 00:00:00 EST 2016

Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.

Nature communications

Martino MM,Maruyama K,Kuhn GA,Satoh T,Takeuchi O,Müller R,Akira S

Tue Mar 22 00:00:00 EDT 2016

Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.

Nature communications

Martino MM,Maruyama K,Kuhn GA,Satoh T,Takeuchi O,Müller R,Akira S

Tue Mar 22 00:00:00 EDT 2016

The Journal of biological chemistry

Luo MC,Zhou SY,Feng DY,Xiao J,Li WY,Xu CD,Wang HY,Zhou T

Fri Oct 14 00:00:00 EDT 2016

Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells.

Nature communications

Zhao Y,Chu X,Chen J,Wang Y,Gao S,Jiang Y,Zhu X,Tan G,Zhao W,Yi H,Xu H,Ma X,Lu Y,Yi Q,Wang S

Fri Aug 05 00:00:00 EDT 2016

Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.

The Journal of biological chemistry

Mei ZZ,Chen XY,Hu SW,Wang N,Ou XL,Wang J,Luo HH,Liu J,Jiang Y

Fri Aug 26 00:00:00 EDT 2016

Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.

Scientific reports

Kawalkowska J,Quirke AM,Ghari F,Davis S,Subramanian V,Thompson PR,Williams RO,Fischer R,La Thangue NB,Venables PJ

Mon May 23 00:00:00 EDT 2016

Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport.

Scientific reports

Song S,Faleo G,Yeung R,Kant R,Posselt AM,Desai TA,Tang Q,Roy S

Thu Mar 24 00:00:00 EDT 2016

Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response.

The Journal of biological chemistry

Pasi S,Kant R,Surolia A

Fri Jun 03 00:00:00 EDT 2016

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.

Scientific reports

Vincendeau M,Hadian K,Messias AC,Brenke JK,Halander J,Griesbach R,Greczmiel U,Bertossi A,Stehle R,Nagel D,Demski K,Velvarska H,Niessing D,Geerlof A,Sattler M,Krappmann D

Thu Jan 07 00:00:00 EST 2016

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.

Scientific reports

Vincendeau M,Hadian K,Messias AC,Brenke JK,Halander J,Griesbach R,Greczmiel U,Bertossi A,Stehle R,Nagel D,Demski K,Velvarska H,Niessing D,Geerlof A,Sattler M,Krappmann D

Thu Jan 07 00:00:00 EST 2016

Macrophage-mediated inflammatory response decreases mycobacterial survival in mouse MSCs by augmenting NO production.

Scientific reports

Yang K,Wu Y,Xie H,Li M,Ming S,Li L,Li M,Wu M,Gong S,Huang X

Thu Jun 02 00:00:00 EDT 2016

A Novel Protective Function of 5-Methoxytryptophan in Vascular Injury.

Scientific reports

Ho YC,Wu ML,Su CH,Chen CH,Ho HH,Lee GL,Lin WS,Lin WY,Hsu YJ,Kuo CC,Wu KK,Yet SF

Thu May 05 00:00:00 EDT 2016

The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells.

Immunity

Ichiyama K,Chen T,Wang X,Yan X,Kim BS,Tanaka S,Ndiaye-Lobry D,Deng Y,Zou Y,Zheng P,Tian Q,Aifantis I,Wei L,Dong C

Tue Apr 21 00:00:00 EDT 2015

Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.

The Journal of clinical investigation

Leoni G,Neumann PA,Kamaly N,Quiros M,Nishio H,Jones HR,Sumagin R,Hilgarth RS,Alam A,Fredman G,Argyris I,Rijcken E,Kusters D,Reutelingsperger C,Perretti M,Parkos CA,Farokhzad OC,Neish AS,Nusrat A

Mon Mar 02 00:00:00 EST 2015

The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function.

The Journal of experimental medicine

Barnes MJ,Li CM,Xu Y,An J,Huang Y,Cyster JG

Mon Jun 29 00:00:00 EDT 2015

IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer.

The Journal of experimental medicine

Koliaraki V,Pasparakis M,Kollias G

Mon Dec 14 00:00:00 EST 2015

Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter.

European journal of immunology

Hill EV,Ng TH,Burton BR,Oakley CM,Malik K,Wraith DC

Wed Apr 01 00:00:00 EDT 2015

NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis.

European journal of immunology

Reppert S,Zinser E,Holzinger C,Sandrock L,Koch S,Finotto S

Fri May 01 00:00:00 EDT 2015

Pretreatment of Mesenchymal Stem Cells Manipulates Their Vasculoprotective Potential While Not Altering Their Homing Within the Injured Gut.

Stem cells (Dayton, Ohio)

Kavanagh DP,Suresh S,Newsome PN,Frampton J,Kalia N

Tue Sep 01 00:00:00 EDT 2015

Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease.

Journal of immunology (Baltimore, Md. : 1950)

Ladell K,Hazenberg MD,Fitch M,Emson C,McEvoy-Hein Asgarian BK,Mold JE,Miller C,Busch R,Price DA,Hellerstein MK,McCune JM

Sun Nov 01 00:00:00 EDT 2015

IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Shimizu K,Nakajima A,Sudo K,Liu Y,Mizoroki A,Ikarashi T,Horai R,Kakuta S,Watanabe T,Iwakura Y

Wed Apr 01 00:00:00 EDT 2015

Composition, Development, and Function of Uterine Innate Lymphoid Cells.

Journal of immunology (Baltimore, Md. : 1950)

Doisne JM,Balmas E,Boulenouar S,Gaynor LM,Kieckbusch J,Gardner L,Hawkes DA,Barbara CF,Sharkey AM,Brady HJ,Brosens JJ,Moffett A,Colucci F

Thu Oct 15 00:00:00 EDT 2015

IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity.

Journal of immunology (Baltimore, Md. : 1950)

Heiseke AF,Jeuk BH,Markota A,Straub T,Lehr HA,Reindl W,Krug AB

Tue Dec 15 00:00:00 EST 2015

Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction.

PloS one

Bremser A,Brack M,Izcue A

211-11B was used in Cell Culture to investigate the effects of TCR signals on T cells through studying the expression of T cell activation marker CD69.

Tue May 24 00:00:00 EDT 2016

SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell.

The Journal of biological chemistry

Fujimaki K,Ogihara T,Morris DL,Oda H,Iida H,Fujitani Y,Mirmira RG,Evans-Molina C,Watada H

Fri Jul 03 00:00:00 EDT 2015

Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes.

Scientific reports

Yamamoto S,Niida S,Azuma E,Yanagibashi T,Muramatsu M,Huang TT,Sagara H,Higaki S,Ikutani M,Nagai Y,Takatsu K,Miyazaki K,Hamashima T,Mori H,Matsuda N,Ishii Y,Sasahara M

Tue Feb 17 00:00:00 EST 2015

Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation.

Nature communications

Yoon JH,Sudo K,Kuroda M,Kato M,Lee IK,Han JS,Nakae S,Imamura T,Kim J,Ju JH,Kim DK,Matsuzaki K,Weinstein M,Matsumoto I,Sumida T,Mamura M

Tue Jul 21 00:00:00 EDT 2015

The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.

Immunity

Tang W,Wang H,Claudio E,Tassi I,Ha HL,Saret S,Siebenlist U

Thu Oct 16 00:00:00 EDT 2014

Long-lived intestinal tuft cells serve as colon cancer-initiating cells.

The Journal of clinical investigation

Westphalen CB,Asfaha S,Hayakawa Y,Takemoto Y,Lukin DJ,Nuber AH,Brandtner A,Setlik W,Remotti H,Muley A,Chen X,May R,Houchen CW,Fox JG,Gershon MD,Quante M,Wang TC

Sat Mar 01 00:00:00 EST 2014

Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.

The Journal of clinical investigation

Choi SH,Kim BG,Robinson J,Fink S,Yan M,Sporn MB,Markowitz SD,Letterio JJ

Sun Jun 01 00:00:00 EDT 2014

Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3.

The Journal of experimental medicine

Tanaka S,Suto A,Iwamoto T,Kashiwakuma D,Kagami S,Suzuki K,Takatori H,Tamachi T,Hirose K,Onodera A,Suzuki J,Ohara O,Yamashita M,Nakayama T,Nakajima H

Mon Aug 25 00:00:00 EDT 2014

Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.

Proceedings of the National Academy of Sciences of the United States of America

Watanabe Y,Onodera A,Kanai U,Ichikawa T,Obata-Ninomiya K,Wada T,Kiuchi M,Iwamura C,Tumes DJ,Shinoda K,Yagi R,Motohashi S,Hirahara K,Nakayama T

Tue Sep 02 00:00:00 EDT 2014

Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.

Proceedings of the National Academy of Sciences of the United States of America

Rei M,Gonçalves-Sousa N,Lança T,Thompson RG,Mensurado S,Balkwill FR,Kulbe H,Pennington DJ,Silva-Santos B

Tue Aug 26 00:00:00 EDT 2014

Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity.

Proceedings of the National Academy of Sciences of the United States of America

Okoye IS,Czieso S,Ktistaki E,Roderick K,Coomes SM,Pelly VS,Kannan Y,Perez-Lloret J,Zhao JL,Baltimore D,Langhorne J,Wilson MS

Tue Jul 29 00:00:00 EDT 2014

Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis.

Proceedings of the National Academy of Sciences of the United States of America

Roulis M,Nikolaou C,Kotsaki E,Kaffe E,Karagianni N,Koliaraki V,Salpea K,Ragoussis J,Aidinis V,Martini E,Becker C,Herschman HR,Vetrano S,Danese S,Kollias G

Tue Oct 28 00:00:00 EDT 2014

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.

Proceedings of the National Academy of Sciences of the United States of America

Kaiser WJ,Daley-Bauer LP,Thapa RJ,Mandal P,Berger SB,Huang C,Sundararajan A,Guo H,Roback L,Speck SH,Bertin J,Gough PJ,Balachandran S,Mocarski ES

Tue May 27 00:00:00 EDT 2014

TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state.

Oncogene

Mori T,Sato Y,Miyamoto K,Kobayashi T,Shimizu T,Kanagawa H,Katsuyama E,Fujie A,Hao W,Tando T,Iwasaki R,Kawana H,Morioka H,Matsumoto M,Saya H,Toyama Y,Miyamoto T

Thu Aug 14 00:00:00 EDT 2014

NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen.

Mucosal immunology

Nordlander S,Pott J,Maloy KJ

211-11B was used in Enzyme-linked immunosorbent assay to study how early NLRC4 sensing in intestinal epithelial cells regulates colonization by an extracellular bacterial pathogen and limits subsequent intestinal damage.

Tue Jul 01 00:00:00 EDT 2014

Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen.

Mucosal immunology

Song-Zhao GX,Srinivasan N,Pott J,Baban D,Frankel G,Maloy KJ

211-11B was used in Enzyme-linked immunosorbent assay to investigate how protection from disease is mediated through Nlrp3 activation in nonhematopoietic cells and is initiated very early after infection.

Tue Jul 01 00:00:00 EDT 2014

Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-β-induced Foxp3 expression.

Journal of immunology (Baltimore, Md. : 1950)

Ikeda S,Saijo S,Murayama MA,Shimizu K,Akitsu A,Iwakura Y

Sat Feb 15 00:00:00 EST 2014

The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.

Journal of immunology (Baltimore, Md. : 1950)

Severa M,Islam SA,Waggoner SN,Jiang Z,Kim ND,Ryan G,Kurt-Jones E,Charo I,Caffrey DR,Boyartchuk VL,Luster AD,Fitzgerald KA

Sat Mar 01 00:00:00 EST 2014

Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.

Journal of immunology (Baltimore, Md. : 1950)

Sriskantharajah S,Gückel E,Tsakiri N,Kierdorf K,Brender C,Ben-Addi A,Veldhoen M,Tsichlis PN,Stockinger B,O'Garra A,Prinz M,Kollias G,Ley SC

Tue Apr 15 00:00:00 EDT 2014

A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction.

Journal of cellular and molecular medicine

Chang YL,Chen TH,Wu YH,Chen GA,Weng TH,Tseng PH,Hsieh SL,Fu SL,Lin CH,Chen CJ,Chu CL,Chio II,Mak TW,Chen NJ

Tue Jul 01 00:00:00 EDT 2014

Opposing TNF-α/IL-1β- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation.

Cell death & disease

Huang RL,Yuan Y,Tu J,Zou GM,Li Q

Thu Apr 17 00:00:00 EDT 2014

Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death.

Scientific reports

Tilstra JS,Gaddy DF,Zhao J,Davé SH,Niedernhofer LJ,Plevy SE,Robbins PD

Fri Jan 10 00:00:00 EST 2014

Tumor necrosis factor and transforming growth factor β regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP).

The Journal of biological chemistry

Lopez M,Meier D,Müller A,Franken P,Fujita J,Fontana A

Fri Jan 31 00:00:00 EST 2014

GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency.

The Journal of clinical investigation

Ye P,Chen W,Wu J,Huang X,Li J,Wang S,Liu Z,Wang G,Yang X,Zhang P,Lv Q,Xia J

Wed May 01 00:00:00 EDT 2013

Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Masuda K,Ripley B,Nishimura R,Mino T,Takeuchi O,Shioi G,Kiyonari H,Kishimoto T

Tue Jun 04 00:00:00 EDT 2013

Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.

Proceedings of the National Academy of Sciences of the United States of America

Lamagna C,Scapini P,van Ziffle JA,DeFranco AL,Lowell CA

Tue Aug 27 00:00:00 EDT 2013

MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.

Proceedings of the National Academy of Sciences of the United States of America

Chang J,Burkett PR,Borges CM,Kuchroo VK,Turka LA,Chang CH

Tue Feb 05 00:00:00 EST 2013

Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-γ production from CD4 T cells.

Journal of immunology (Baltimore, Md. : 1950)

Yamashita J,Iwamura C,Ito T,Narita M,Hara Y,Sasaki T,Masuda D,Takahashi M,Tsuchiya M,Hada K,Ishikawa M,Matsuo T,Ohno Y,Tanaka H,Maruyama H,Ogawa Y,Nakayama T

Mon Jul 15 00:00:00 EDT 2013

Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

Journal of immunology (Baltimore, Md. : 1950)

Pham D,Yu Q,Walline CC,Muthukrishnan R,Blum JS,Kaplan MH

Mon Jul 15 00:00:00 EDT 2013

The role of IL-1β in the early tumor cell-induced angiogenic response.

Journal of immunology (Baltimore, Md. : 1950)

Carmi Y,Dotan S,Rider P,Kaplanov I,White MR,Baron R,Abutbul S,Huszar M,Dinarello CA,Apte RN,Voronov E

Mon Apr 01 00:00:00 EDT 2013

CD47 deficiency does not impede polymorphonuclear neutrophil transmigration but attenuates granulopoiesis at the postacute stage of colitis.

Journal of immunology (Baltimore, Md. : 1950)

Bian Z,Guo Y,Luo Y,Tremblay A,Zhang X,Dharma S,Mishra A,Liu Y

Tue Jan 01 00:00:00 EST 2013

IL-23-independent induction of IL-17 from γδT cells and innate lymphoid cells promotes experimental intraocular neovascularization.

Journal of immunology (Baltimore, Md. : 1950)

Hasegawa E,Sonoda KH,Shichita T,Morita R,Sekiya T,Kimura A,Oshima Y,Takeda A,Yoshimura T,Yoshida S,Ishibashi T,Yoshimura A

Fri Feb 15 00:00:00 EST 2013

Inflammatory cytokine-mediated evasion of virus-induced tumors from NK cell control.

Journal of immunology (Baltimore, Md. : 1950)

Mishra R,Polic B,Welsh RM,Szomolanyi-Tsuda E

Mon Jul 15 00:00:00 EDT 2013

Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection.

Journal of immunology (Baltimore, Md. : 1950)

Hamada H,Bassity E,Flies A,Strutt TM,Garcia-Hernandez Mde L,McKinstry KK,Zou T,Swain SL,Dutton RW

Tue Jan 01 00:00:00 EST 2013

Suprachiasmatic astrocytes modulate the circadian clock in response to TNF-α.

Journal of immunology (Baltimore, Md. : 1950)

Duhart JM,Leone MJ,Paladino N,Evans JA,Castanon-Cervantes O,Davidson AJ,Golombek DA

Fri Nov 01 00:00:00 EDT 2013

Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2.

Journal of translational medicine

Przybyt E,Krenning G,Brinker MG,Harmsen MC

Wed Feb 13 00:00:00 EST 2013

Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2.

Journal of translational medicine

Przybyt E,Krenning G,Brinker MG,Harmsen MC

Wed Feb 13 00:00:00 EST 2013

Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2.

Journal of translational medicine

Przybyt E,Krenning G,Brinker MG,Harmsen MC

Wed Feb 13 00:00:00 EST 2013

The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.

The Journal of biological chemistry

Pham D,Walline CC,Hollister K,Dent AL,Blum JS,Firulli AB,Kaplan MH

Fri Sep 20 00:00:00 EDT 2013

Do β-cells generate peroxynitrite in response to cytokine treatment?

The Journal of biological chemistry

Broniowska KA,Mathews CE,Corbett JA

Fri Dec 20 00:00:00 EST 2013

Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression.

Blood

Adhikary S,Kocieda VP,Yen JH,Tuma RF,Ganea D

Thu Nov 01 00:00:00 EDT 2012

SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection.

Cellular & molecular immunology

Zhang X,Han S,Kang Y,Guo M,Hong S,Liu F,Fu S,Wang L,Wang QX

Sat Sep 01 00:00:00 EDT 2012

Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.

The Journal of clinical investigation

Yiakouvaki A,Dimitriou M,Karakasiliotis I,Eftychi C,Theocharis S,Kontoyiannis DL

Sun Jan 01 00:00:00 EST 2012

Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.

The Journal of clinical investigation

Koliaraki V,Roulis M,Kollias G

Thu Nov 01 00:00:00 EDT 2012

Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.

The Journal of experimental medicine

Nowak EC,de Vries VC,Wasiuk A,Ahonen C,Bennett KA,Le Mercier I,Ha DG,Noelle RJ

Mon Oct 22 00:00:00 EDT 2012

High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.

The Journal of experimental medicine

Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ

Mon Jan 16 00:00:00 EST 2012

Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing.

Proceedings of the National Academy of Sciences of the United States of America

Descamps D,Le Gars M,Balloy V,Barbier D,Maschalidi S,Tohme M,Chignard M,Ramphal R,Manoury B,Sallenave JM

Tue Jan 31 00:00:00 EST 2012

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response.

Cellular and molecular life sciences : CMLS

Wann AK,Knight MM

Sat Sep 01 00:00:00 EDT 2012

Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Schiffmann S,Ferreiros N,Birod K,Eberle M,Schreiber Y,Pfeilschifter W,Ziemann U,Pierre S,Scholich K,Grösch S,Geisslinger G

Fri Jun 01 00:00:00 EDT 2012

Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions.

Journal of immunology (Baltimore, Md. : 1950)

Bian Z,Guo Y,Ha B,Zen K,Liu Y

Sun Jan 15 00:00:00 EST 2012

Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.

Journal of immunology (Baltimore, Md. : 1950)

Pham D,Vincentz JW,Firulli AB,Kaplan MH

Sun Jul 15 00:00:00 EDT 2012

Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.

The Journal of biological chemistry

Khanna-Gupta A,Abayasekara N,Levine M,Sun H,Virgilio M,Nia N,Halene S,Sportoletti P,Jeong JY,Pandolfi PP,Berliner N

Fri Sep 21 00:00:00 EDT 2012

Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages.

The Journal of biological chemistry

Paget C,Ivanov S,Fontaine J,Renneson J,Blanc F,Pichavant M,Dumoutier L,Ryffel B,Renauld JC,Gosset P,Gosset P,Si-Tahar M,Faveeuw C,Trottein F

Fri Mar 16 00:00:00 EDT 2012

In vitro phenotypic, genomic and proteomic characterization of a cytokine-resistant murine β-TC3 cell line.

PloS one

Coppola A,Tomasello L,Pizzolanti G,Pucci-Minafra I,Albanese N,Di Cara G,Cancemi P,Pitrone M,Bommarito A,Carissimi E,Zito G,Criscimanna A,Galluzzo A,Giordano C

Mon Jul 23 00:00:00 EDT 2012

Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735.

PloS one

Hall KC,Blobel CP

Mon Aug 27 00:00:00 EDT 2012

MicroRNA-124 as a novel treatment for persistent hyperalgesia.

Journal of neuroinflammation

Willemen HL,Huo XJ,Mao-Ying QL,Zijlstra J,Heijnen CJ,Kavelaars A

Mon Jun 25 00:00:00 EDT 2012

Comparison of the virulence potential of Acinetobacter strains from clinical and environmental sources.

PloS one

Tayabali AF,Nguyen KC,Shwed PS,Crosthwait J,Coleman G,Seligy VL

Thu Sep 27 00:00:00 EDT 2012

Comparison of the virulence potential of Acinetobacter strains from clinical and environmental sources.

PloS one

Tayabali AF,Nguyen KC,Shwed PS,Crosthwait J,Coleman G,Seligy VL

Thu Sep 27 00:00:00 EDT 2012

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity.

Nature

Sander LE,Davis MJ,Boekschoten MV,Amsen D,Dascher CC,Ryffel B,Swanson JA,Müller M,Blander JM

Sun May 22 00:00:00 EDT 2011

RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.

Immunity

Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F

Fri Mar 25 00:00:00 EDT 2011

Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms.

Immunity

Kuroda E,Ishii KJ,Uematsu S,Ohata K,Coban C,Akira S,Aritake K,Urade Y,Morimoto Y

Fri Apr 22 00:00:00 EDT 2011

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling.

Nature immunology

Wen H,Gris D,Lei Y,Jha S,Zhang L,Huang MT,Brickey WJ,Ting JP

Sun May 01 00:00:00 EDT 2011

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A.

Blood

Joyal JS,Sitaras N,Binet F,Rivera JC,Stahl A,Zaniolo K,Shao Z,Polosa A,Zhu T,Hamel D,Djavari M,Kunik D,Honoré JC,Picard E,Zabeida A,Varma DR,Hickson G,Mancini J,Klagsbrun M,Costantino S,Beauséjour C,Lachapelle P,Smith LE,Chemtob S,Sapieha P

Thu Jun 02 00:00:00 EDT 2011

TAK1 in brain endothelial cells mediates fever and lethargy.

The Journal of experimental medicine

Ridder DA,Lang MF,Salinin S,Röderer JP,Struss M,Maser-Gluth C,Schwaninger M

Mon Dec 19 00:00:00 EST 2011

Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature.

Journal of immunology (Baltimore, Md. : 1950)

Brancaleone V,Dalli J,Bena S,Flower RJ,Cirino G,Perretti M

Fri Apr 15 00:00:00 EDT 2011

Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria.

Journal of immunology (Baltimore, Md. : 1950)

Doisne JM,Soulard V,Bécourt C,Amniai L,Henrot P,Havenar-Daughton C,Blanchet C,Zitvogel L,Ryffel B,Cavaillon JM,Marie JC,Couillin I,Benlagha K

Sat Jan 15 00:00:00 EST 2011

Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis.

Journal of immunology (Baltimore, Md. : 1950)

Carmi Y,Rinott G,Dotan S,Elkabets M,Rider P,Voronov E,Apte RN

Tue Mar 15 00:00:00 EDT 2011

Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Wang L,Du C,Lv J,Wei W,Cui Y,Xie X

Thu Sep 01 00:00:00 EDT 2011

The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia.

Journal of immunology (Baltimore, Md. : 1950)

Möser CV,Kynast K,Baatz K,Russe OQ,Ferreirós N,Costiuk H,Lu R,Schmidtko A,Tegeder I,Geisslinger G,Niederberger E

Thu Sep 01 00:00:00 EDT 2011

Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis.

Clinical & experimental metastasis

Seike T,Fujita K,Yamakawa Y,Kido MA,Takiguchi S,Teramoto N,Iguchi H,Noda M

Sat Jan 01 00:00:00 EST 2011

Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis.

Clinical & experimental metastasis

Seike T,Fujita K,Yamakawa Y,Kido MA,Takiguchi S,Teramoto N,Iguchi H,Noda M

Sat Jan 01 00:00:00 EST 2011

Influence of synthetic superparamagnetic iron oxide on dendritic cells.

International journal of nanomedicine

Mou Y,Chen B,Zhang Y,Hou Y,Xie H,Xia G,Tang M,Huang X,Ni Y,Hu Q

Wed Feb 08 00:00:00 EST 2012

Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.

PloS one

Takeuchi H,Yokota A,Ohoka Y,Iwata M

Fri Jan 07 00:00:00 EST 2011

In vivo migration of dendritic cells labeled with synthetic superparamagnetic iron oxide.

International journal of nanomedicine

Mou Y,Hou Y,Chen B,Hua Z,Zhang Y,Xie H,Xia G,Wang Z,Huang X,Han W,Ni Y,Hu Q

Tue Mar 27 00:00:00 EDT 2012

Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.

PloS one

Haas JD,Nistala K,Petermann F,Saran N,Chennupati V,Schmitz S,Korn T,Wedderburn LR,Förster R,Krueger A,Prinz I

Thu Sep 29 00:00:00 EDT 2011

Early effects of lipopolysaccharide-induced inflammation on foetal brain development in rat.

ASN neuro

Ghiani CA,Mattan NS,Nobuta H,Malvar JS,Boles J,Ross MG,Waschek JA,Carpenter EM,Fisher RS,de Vellis J

Thu Nov 17 00:00:00 EST 2011

Nitric oxide-induced activation of the AMP-activated protein kinase α2 subunit attenuates IκB kinase activity and inflammatory responses in endothelial cells.

PloS one

Bess E,Fisslthaler B,Frömel T,Fleming I

Fri Sep 30 00:00:00 EDT 2011

The non-phagocytic route of collagen uptake: a distinct degradation pathway.

The Journal of biological chemistry

Madsen DH,Ingvarsen S,Jürgensen HJ,Melander MC,Kjøller L,Moyer A,Honoré C,Madsen CA,Garred P,Burgdorf S,Bugge TH,Behrendt N,Engelholm LH

Fri Jul 29 00:00:00 EDT 2011

A dual role for microglia in promoting tissue inhibitor of metalloproteinase (TIMP) expression in glial cells in response to neuroinflammatory stimuli.

Journal of neuroinflammation

Welser-Alves JV,Crocker SJ,Milner R

Wed Jun 01 00:00:00 EDT 2011

MHC mismatch inhibits neurogenesis and neuron maturation in stem cell allografts.

PloS one

Chen Z,Phillips LK,Gould E,Campisi J,Lee SW,Ormerod BK,Zwierzchoniewska M,Martinez OM,Palmer TD

Wed Mar 30 00:00:00 EDT 2011

Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.

PloS one

Siegert S,Huang HY,Yang CY,Scarpellino L,Carrie L,Essex S,Nelson PJ,Heikenwalder M,Acha-Orbea H,Buckley CD,Marsland BJ,Zehn D,Luther SA

Mon Mar 26 00:00:00 EDT 2012

Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature.

Blood

Pederzoli-Ribeil M,Maione F,Cooper D,Al-Kashi A,Dalli J,Perretti M,D'Acquisto F

Thu Nov 18 00:00:00 EST 2010

TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.

Blood

Cejas PJ,Walsh MC,Pearce EL,Han D,Harms GM,Artis D,Turka LA,Choi Y

Thu Jun 10 00:00:00 EDT 2010

Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.

The Journal of clinical investigation

Melton AC,Bailey-Bucktrout SL,Travis MA,Fife BT,Bluestone JA,Sheppard D

Wed Dec 01 00:00:00 EST 2010

Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine.

Journal of immunology (Baltimore, Md. : 1950)

Wang C,Kang SG,HogenEsch H,Love PE,Kim CH

Sat May 15 00:00:00 EDT 2010

Lymphatic endothelial murine chloride channel calcium-activated 1 is a ligand for leukocyte LFA-1 and Mac-1.

Journal of immunology (Baltimore, Md. : 1950)

Furuya M,Kirschbaum SB,Paulovich A,Pauli BU,Zhang H,Alexander JS,Farr AG,Ruddell A

Mon Nov 15 00:00:00 EST 2010

Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Kastner L,Dwyer D,Qin FX

Mon Nov 15 00:00:00 EST 2010

5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity.

Journal of immunology (Baltimore, Md. : 1950)

Horrillo R,González-Périz A,Martínez-Clemente M,López-Parra M,Ferré N,Titos E,Morán-Salvador E,Deulofeu R,Arroyo V,Clària J

Thu Apr 01 00:00:00 EDT 2010

5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity.

Journal of immunology (Baltimore, Md. : 1950)

Horrillo R,González-Périz A,Martínez-Clemente M,López-Parra M,Ferré N,Titos E,Morán-Salvador E,Deulofeu R,Arroyo V,Clària J

Thu Apr 01 00:00:00 EDT 2010

Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Dufton N,Hannon R,Brancaleone V,Dalli J,Patel HB,Gray M,D'Acquisto F,Buckingham JC,Perretti M,Flower RJ

Mon Mar 01 00:00:00 EST 2010

"Default" generation of neonatal regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Wang G,Miyahara Y,Guo Z,Khattar M,Stepkowski SM,Chen W

Thu Jul 01 00:00:00 EDT 2010

IFN-beta inhibits dendritic cell migration through STAT-1-mediated transcriptional suppression of CCR7 and matrix metalloproteinase 9.

Journal of immunology (Baltimore, Md. : 1950)

Yen JH,Kong W,Ganea D

Thu Apr 01 00:00:00 EDT 2010

MEKK3 overexpression contributes to the hyperresponsiveness of IL-12-overproducing cells and CD4+ T conventional cells in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950)

Zhang J,Zhu N,Wang Q,Wang J,Ma Y,Qiao C,Li Y,Li X,Su B,Shen B

Wed Sep 15 00:00:00 EDT 2010

SMAD2 is essential for TGF beta-mediated Th17 cell generation.

The Journal of biological chemistry

Malhotra N,Robertson E,Kang J

Fri Sep 17 00:00:00 EDT 2010

CCL2 modulates cytokine production in cultured mouse astrocytes.

Journal of neuroinflammation

Semple BD,Frugier T,Morganti-Kossmann MC

Thu Oct 14 00:00:00 EDT 2010

Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1).

The Journal of biological chemistry

Kaieda S,Shin K,Nigrovic PA,Seki K,Lee RT,Stevens RL,Lee DM

Fri Jul 09 00:00:00 EDT 2010

Central control of fever and female body temperature by RANKL/RANK.

Nature

Hanada R,Leibbrandt A,Hanada T,Kitaoka S,Furuyashiki T,Fujihara H,Trichereau J,Paolino M,Qadri F,Plehm R,Klaere S,Komnenovic V,Mimata H,Yoshimatsu H,Takahashi N,von Haeseler A,Bader M,Kilic SS,Ueta Y,Pifl C,Narumiya S,Penninger JM

Thu Nov 26 00:00:00 EST 2009

Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.

Immunity

Gomez-Rodriguez J,Sahu N,Handon R,Davidson TS,Anderson SM,Kirby MR,August A,Schwartzberg PL

Fri Oct 16 00:00:00 EDT 2009

In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations.

Blood

Carlson MJ,West ML,Coghill JM,Panoskaltsis-Mortari A,Blazar BR,Serody JS

Thu Feb 05 00:00:00 EST 2009

Interferon beta induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation.

Blood

Yen JH,Ganea D

Thu Aug 13 00:00:00 EDT 2009

External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers.

The Journal of experimental medicine

Kubo A,Nagao K,Yokouchi M,Sasaki H,Amagai M

Mon Dec 21 00:00:00 EST 2009

Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates.

The EMBO journal

Pelegrin P,Surprenant A

Wed Jul 22 00:00:00 EDT 2009

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Ben-Sasson SZ,Hu-Li J,Quiel J,Cauchetaux S,Ratner M,Shapira I,Dinarello CA,Paul WE

Tue Apr 28 00:00:00 EDT 2009

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.

Proceedings of the National Academy of Sciences of the United States of America

Guo L,Wei G,Zhu J,Liao W,Leonard WJ,Zhao K,Paul W

Tue Aug 11 00:00:00 EDT 2009

Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts.

Journal of immunology (Baltimore, Md. : 1950)

Yoshimi R,Chang TH,Wang H,Atsumi T,Morse HC,Ozato K

Mon Jun 15 00:00:00 EDT 2009

Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.

Journal of immunology (Baltimore, Md. : 1950)

Hamada H,Garcia-Hernandez Mde L,Reome JB,Misra SK,Strutt TM,McKinstry KK,Cooper AM,Swain SL,Dutton RW

Sun Mar 15 00:00:00 EDT 2009

IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia.

Journal of immunology (Baltimore, Md. : 1950)

Ueda Y,Cain DW,Kuraoka M,Kondo M,Kelsoe G

Fri May 15 00:00:00 EDT 2009

A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.

Journal of immunology (Baltimore, Md. : 1950)

Izhak L,Wildbaum G,Zohar Y,Anunu R,Klapper L,Elkeles A,Seagal J,Yefenof E,Ayalon-Soffer M,Karin N

Wed Jul 01 00:00:00 EDT 2009

Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes.

Journal of immunology (Baltimore, Md. : 1950)

Fiorina P,Jurewicz M,Augello A,Vergani A,Dada S,La Rosa S,Selig M,Godwin J,Law K,Placidi C,Smith RN,Capella C,Rodig S,Adra CN,Atkinson M,Sayegh MH,Abdi R

Wed Jul 15 00:00:00 EDT 2009

Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation.

The Journal of biological chemistry

Martinez GJ,Zhang Z,Chung Y,Reynolds JM,Lin X,Jetten AM,Feng XH,Dong C

Fri Dec 18 00:00:00 EST 2009

Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo.

Blood

Orelio C,Haak E,Peeters M,Dzierzak E

Mon Dec 15 00:00:00 EST 2008

CD40 mediates retinal inflammation and neurovascular degeneration.

Journal of immunology (Baltimore, Md. : 1950)

Portillo JA,Van Grol J,Zheng L,Okenka G,Gentil K,Garland A,Carlson EC,Kern TS,Subauste CS

Mon Dec 15 00:00:00 EST 2008

Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.

The Journal of biological chemistry

Shibata H,Yoshioka Y,Ohkawa A,Minowa K,Mukai Y,Abe Y,Taniai M,Nomura T,Kayamuro H,Nabeshi H,Sugita T,Imai S,Nagano K,Yoshikawa T,Fujita T,Nakagawa S,Yamamoto A,Ohta T,Hayakawa T,Mayumi T,Vandenabeele P,Aggarwal BB,Nakamura T,Yamagata Y,Tsunoda S,Kamada H,Tsutsumi Y

Fri Jan 11 00:00:00 EST 2008

Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.

The Journal of biological chemistry

Fri Jan 11 00:00:00 EST 2008

Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene.

Blood

Khanna-Gupta A,Sun H,Zibello T,Lee HM,Dahl R,Boxer LA,Berliner N

Tue May 15 00:00:00 EDT 2007

IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B

Sat Dec 15 00:00:00 EST 2007

Bioinformatics

Protein Aliases: Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1β; IL-1 beta; IL1 B; IL1β; ILN; Interleukin; Interleukin 1 beta precursor; Interleukin-1 beta; Interleukin-1b; Interleukin1 beta; LAF; Osteoclast activating factor (OAF); Pro interleukin 1 beta

Mouse IL-1 beta Recombinant Protein, PeproTech®

Mouse IL-1 beta Protein (211-11B-10UG) in Functional

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211-11B-10UG

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