Product References
Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation.
Mucosal immunology
Spalinger MR,Crawford M,Bobardt SD,Li J,Sayoc-Becerra A,Santos AN,Shawki A,Chatterjee P,Nair MG,McCole DF
Sat Jan 01 00:00:00 EST 2022
Metabolic reprogramming of tumor-associated macrophages by collagen turnover promotes fibrosis in pancreatic cancer.
Proceedings of the National Academy of Sciences of the United States of America
LaRue MM,Parker S,Puccini J,Cammer M,Kimmelman AC,Bar-Sagi D
210-10 was used in Cell Culture to identify a role for extracellular matrix remodeling in the functional modulation of tumor-associated macrophages via metabolic rewiring.
Tue Apr 19 00:00:00 EDT 2022
AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells.
Cell reports. Medicine
Li H,Liu Z,Liu L,Zhang H,Han C,Girard L,Park H,Zhang A,Dong C,Ye J,Rayford A,Peyton M,Li X,Avila K,Cao X,Hu S,Alam MM,Akbay EA,Solis LM,Behrens C,Hernandez-Ruiz S,Lu W,Wistuba I,Heymach JV,Chisamore M,Micklem D,Gabra H,Gausdal G,Lorens JB,Li B,Fu YX,Minna JD,Brekken RA
210-10 was used in Cell Culture to explore why mutations in STK11/LKB1 in non-small lung cancer are associated with poor patient responses to immune checkpoint blockade and introduction of Stk11/Lkb1 mutation into murine lung adenocarcinomas driven by mutant Kras and Trp53 loss resulted in an ICB refractory syngeneic KPL tumour.
Tue Mar 15 00:00:00 EDT 2022
Inactivation of AUF1 in Myeloid Cells Protects From Allergic Airway and Tumor Infiltration and Impairs the Adenosine-Induced Polarization of Pro-Angiogenic Macrophages.
Frontiers in immunology
Gargani S,Lourou N,Arapatzi C,Tzanos D,Saridaki M,Dushku E,Chatzimike M,Sidiropoulos ND,Andreadou M,Ntafis V,Hatzis P,Kostourou V,Kontoyiannis DL
210-10 was used in Cell Culture to study the requirement of AUF1s in variable contexts of innate immune reactivity by restricting a debilitating AUF1 mutation to the mouse myeloid lineage and perform disease-oriented phenotypic analyses.
Fri Apr 08 00:00:00 EDT 2022
METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells.
Nature communications
Song H,Song J,Cheng M,Zheng M,Wang T,Tian S,Flavell RA,Zhu S,Li HB,Ding C,Wei H,Sun R,Peng H,Tian Z
Fri Sep 17 00:00:00 EDT 2021
Generation of a chemical genetic model for JAK3.
Scientific reports
Remenyi J,Naik RJ,Wang J,Razsolkov M,Verano A,Cai Q,Tan L,Toth R,Raggett S,Baillie C,Traynor R,Hastie CJ,Gray NS,Arthur JSC
Wed May 12 00:00:00 EDT 2021
Single-cell secretion analysis reveals a dual role for IL-10 in restraining and resolving the TLR4-induced inflammatory response.
Cell reports
Alexander AF,Kelsey I,Forbes H,Miller-Jensen K
Tue Sep 21 00:00:00 EDT 2021
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.
Nature communications
Zhang L,Zhang K,Zhang J,Zhu J,Xi Q,Wang H,Zhang Z,Cheng Y,Yang G,Liu H,Guo X,Zhou D,Xue Z,Li Y,Zhang Q,Da Y,Liu L,Yin Z,Yao Z,Zhang R
Wed Jul 14 00:00:00 EDT 2021
Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses.
Immunity
Wong R,Belk JA,Govero J,Uhrlaub JL,Reinartz D,Zhao H,Errico JM,D'Souza L,Ripperger TJ,Nikolich-Zugich J,Shlomchik MJ,Satpathy AT,Fremont DH,Diamond MS,Bhattacharya D
Tue Nov 17 00:00:00 EST 2020
JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.
Blood
Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE
Thu Aug 06 00:00:00 EDT 2020
IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells.
The Journal of experimental medicine
Yang Z,Wu CM,Targ S,Allen CDC
Mon May 04 00:00:00 EDT 2020
ILC2s are the predominant source of intestinal ILC-derived IL-10.
The Journal of experimental medicine
Bando JK,Gilfillan S,Di Luccia B,Fachi JL,Sécca C,Cella M,Colonna M
210-10 was used in Cell Culture to report the absence of an intestinal regulatory ILC population distinct from group 1 ILCs (ILC1s), ILC2s, and ILC3s in (1) mice bred in our animal facility; (2) mice from The Jackson Laboratory, Taconic Biosciences, and Charles River Laboratories; and (3) mice subjected to intestinal inflammation.
Mon Feb 03 00:00:00 EST 2020
Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway.
The EMBO journal
Ipseiz N,Pickering RJ,Rosas M,Tyrrell VJ,Davies LC,Orr SJ,Czubala MA,Fathalla D,Robertson AA,Bryant CE,O'Donnell V,Taylor PR
Wed Jul 15 00:00:00 EDT 2020
HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling.
Proceedings of the National Academy of Sciences of the United States of America
Higuchi Y,Yasunaga JI,Mitagami Y,Tsukamoto H,Nakashima K,Ohshima K,Matsuoka M
Tue Jun 16 00:00:00 EDT 2020
The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice.
Journal of immunology (Baltimore, Md. : 1950)
Lewis BW,Choudhary I,Paudel K,Mao Y,Sharma R,Wang Y,Deshane JS,Boucher RC,Patial S,Saini Y
Tue Sep 15 00:00:00 EDT 2020
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Journal of immunology (Baltimore, Md. : 1950)
Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D
Thu Oct 15 00:00:00 EDT 2020
The Wnt-β-Catenin-IL-10 Signaling Axis in Intestinal APCs Protects Mice from Colitis-Associated Colon Cancer in Response to Gut Microbiota.
Journal of immunology (Baltimore, Md. : 1950)
Swafford D,Shanmugam A,Ranganathan P,Manoharan I,Hussein MS,Patel N,Sifuentes H,Koni PA,Prasad PD,Thangaraju M,Manicassamy S
Thu Oct 15 00:00:00 EDT 2020
Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo.
Scientific reports
Cai S,Choi JY,Borges TJ,Zhang H,Miao J,Ichimura T,Li X,Xu S,Chu P,Eskandari SK,Allos H,Alhaddad JB,Muhsin SA,Yatim K,Riella LV,Sage PT,Chandraker AK,Azzi JR
Fri Aug 28 00:00:00 EDT 2020
Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
Scientific reports
Svendsen P,Etzerodt A,Deleuran BW,Moestrup SK
Fri Jul 24 00:00:00 EDT 2020
MicroRNAs of the miR-17~9 family maintain adipose tissue macrophage homeostasis by sustaining IL-10 expression.
eLife
Zhang X,Liu J,Wu L,Hu X
210-10 was used in In vitro experiments to identifiy miR-17~92 family miRNAs as crucial regulators of the balance between pro- and anti-inflammatory cytokines and exemplify how macrophage-intrinsic regulatory circuit exerted impactful influence on general physiology.
Thu Nov 05 00:00:00 EST 2020
Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses.
Immunity
Ji L,Zhao X,Zhang B,Kang L,Song W,Zhao B,Xie W,Chen L,Hu X
Tue Aug 20 00:00:00 EDT 2019
Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8+ T Cell Apoptosis.
Cancer cell
Qiao J,Liu Z,Dong C,Luan Y,Zhang A,Moore C,Fu K,Peng J,Wang Y,Ren Z,Han C,Xu T,Fu YX
Mon Jun 10 00:00:00 EDT 2019
Mesenchymal stem cells prevent the progression of diabetic nephropathy by improving mitochondrial function in tubular epithelial cells.
Experimental & molecular medicine
Lee SE,Jang JE,Kim HS,Jung MK,Ko MS,Kim MO,Park HS,Oh W,Choi SJ,Jin HJ,Kim SY,Kim YJ,Kim SW,Kim MK,Sung CO,Pack CG,Lee KU,Koh EH
Tue Jul 09 00:00:00 EDT 2019
IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses.
eLife
Gottschalk RA,Dorrington MG,Dutta B,Krauss KS,Martins AJ,Uderhardt S,Chan W,Tsang JS,Torabi-Parizi P,Fraser ID,Germain RN
210-10 was used in Cell Culture to investigate the mechanisms involved in inflammatory responses in different classes of bacteria.
Tue Aug 06 00:00:00 EDT 2019
A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma.
Cancers
White CL,Jayasekara WSN,Picard D,Chen J,Watkins DN,Cain JE,Remke M,Gough DJ
210-10 was used in Cell Culture to identify a sex-specific role for the transcription factor Signal Transducer and Activator of Transcription 3 in the Sonic Hedgehog medulloblastoma subgroup.
Fri Nov 01 00:00:00 EDT 2019
Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses.
Scientific reports
Minshawi F,White MRH,Muller W,Humphreys N,Jackson D,Campbell BJ,Adamson A,Papoutsopoulou S
Thu Jan 17 00:00:00 EST 2019
Innate immune memory in the brain shapes neurological disease hallmarks.
Nature
Wendeln AC,Degenhardt K,Kaurani L,Gertig M,Ulas T,Jain G,Wagner J,Häsler LM,Wild K,Skodras A,Blank T,Staszewski O,Datta M,Centeno TP,Capece V,Islam MR,Kerimoglu C,Staufenbiel M,Schultze JL,Beyer M,Prinz M,Jucker M,Fischer A,Neher JJ
Sun Apr 01 00:00:00 EDT 2018
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.
Nature
Xu M,Pokrovskii M,Ding Y,Yi R,Au C,Harrison OJ,Galan C,Belkaid Y,Bonneau R,Littman DR
Thu Feb 15 00:00:00 EST 2018
IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure.
Cell
Rajbhandari P,Thomas BJ,Feng AC,Hong C,Wang J,Vergnes L,Sallam T,Wang B,Sandhu J,Seldin MM,Lusis AJ,Fong LG,Katz M,Lee R,Young SG,Reue K,Smale ST,Tontonoz P
Thu Jan 11 00:00:00 EST 2018
IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure.
Cell
Rajbhandari P,Thomas BJ,Feng AC,Hong C,Wang J,Vergnes L,Sallam T,Wang B,Sandhu J,Seldin MM,Lusis AJ,Fong LG,Katz M,Lee R,Young SG,Reue K,Smale ST,Tontonoz P
Thu Jan 11 00:00:00 EST 2018
T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.
Immunity
Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W
Tue Apr 17 00:00:00 EDT 2018
Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution.
Immunity
Proto JD,Doran AC,Gusarova G,Yurdagul A,Sozen E,Subramanian M,Islam MN,Rymond CC,Du J,Hook J,Kuriakose G,Bhattacharya J,Tabas I
Tue Oct 16 00:00:00 EDT 2018
TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer.
Cancer cell
de Mingo Pulido Á,Gardner A,Hiebler S,Soliman H,Rugo HS,Krummel MF,Coussens LM,Ruffell B
Mon Jan 08 00:00:00 EST 2018
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.
The Journal of experimental medicine
Aden K,Tran F,Ito G,Sheibani-Tezerji R,Lipinski S,Kuiper JW,Tschurtschenthaler M,Saveljeva S,Bhattacharyya J,Häsler R,Bartsch K,Luzius A,Jentzsch M,Falk-Paulsen M,Stengel ST,Welz L,Schwarzer R,Rabe B,Barchet W,Krautwald S,Hartmann G,Pasparakis M,Blumberg RS,Schreiber S,Kaser A,Rosenstiel P
Mon Nov 05 00:00:00 EST 2018
Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment.
The Journal of experimental medicine
Lee SH,Charmoy M,Romano A,Paun A,Chaves MM,Cope FO,Ralph DA,Sacks DL
Tue Jan 02 00:00:00 EST 2018
Cardiac macrophages promote diastolic dysfunction.
The Journal of experimental medicine
Hulsmans M,Sager HB,Roh JD,Valero-Muñoz M,Houstis NE,Iwamoto Y,Sun Y,Wilson RM,Wojtkiewicz G,Tricot B,Osborne MT,Hung J,Vinegoni C,Naxerova K,Sosnovik DE,Zile MR,Bradshaw AD,Liao R,Tawakol A,Weissleder R,Rosenzweig A,Swirski FK,Sam F,Nahrendorf M
Mon Feb 05 00:00:00 EST 2018
Inhaled IL-10 Suppresses Lung Tumorigenesis via Abrogation of Inflammatory Macrophage-Th17 Cell Axis.
Journal of immunology (Baltimore, Md. : 1950)
Li Q,Anderson CD,Egilmez NK
Thu Nov 01 00:00:00 EDT 2018
Myeloid Cell-Restricted STAT3 Signaling Controls a Cell-Autonomous Antifibrotic Repair Program.
Journal of immunology (Baltimore, Md. : 1950)
Do NN,Willenborg S,Eckes B,Jüngst C,Sengle G,Zaucke F,Eming SA
Sun Jul 15 00:00:00 EDT 2018
TGF-β1 Suppresses the Type I IFN Response and Induces Mitochondrial Dysfunction in Alveolar Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Grunwell JR,Yeligar SM,Stephenson S,Ping XD,Gauthier TW,Fitzpatrick AM,Brown LAS
Thu Mar 15 00:00:00 EDT 2018
The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration.
Cell death & disease
Dollt C,Michel J,Kloss L,Melchers S,Schledzewski K,Becker K,Sauer A,Krewer A,Koll F,Schmieder A
Wed Sep 19 00:00:00 EDT 2018
Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease.
Scientific reports
Nakamura J,Watanabe S,Kimura H,Kobayashi M,Karasawa T,Kamata R,Usui-Kawanishi F,Sadatomo A,Mizukami H,Nagi-Miura N,Ohno N,Kasahara T,Minota S,Takahashi M
Tue May 15 00:00:00 EDT 2018
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
Thu Sep 21 00:00:00 EDT 2017
On the Role IL-4/IL-13 Heteroreceptor Plays in Regulation of Type 1 Diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Ukah TK,Cattin-Roy AN,Chen W,Miller MM,Barik S,Zaghouani H
Tue Aug 01 00:00:00 EDT 2017
Neuroendocrine Modulation of IL-27 in Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Roewe J,Higer M,Riehl DR,Gericke A,Radsak MP,Bosmann M
Sun Oct 01 00:00:00 EDT 2017
Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.
NPJ Parkinson's disease
Sarkar S,Malovic E,Harishchandra DS,Ghaisas S,Panicker N,Charli A,Palanisamy BN,Rokad D,Jin H,Anantharam V,Kanthasamy A,Kanthasamy AG
Wed Sep 30 00:00:00 EDT 2020
Tolerogenic dendritic cells are efficiently generated using minocycline and dexamethasone.
Scientific reports
Lee JH,Park CS,Jang S,Kim JW,Kim SH,Song S,Kim K,Lee CK
Wed Nov 08 00:00:00 EST 2017
T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions.
The Journal of biological chemistry
Van de Velde LA,Subramanian C,Smith AM,Barron L,Qualls JE,Neale G,Alfonso-Pecchio A,Jackowski S,Rock CO,Wynn TA,Murray PJ
Fri Jan 06 00:00:00 EST 2017
Characterization of c-Maf+Foxp3- Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells.
Scientific reports
Chien CH,Yu HC,Chen SY,Chiang BL
Wed Apr 12 00:00:00 EDT 2017
IL-12 Signals through the TCR To Support CD8 Innate Immune Responses.
Journal of immunology (Baltimore, Md. : 1950)
Goplen NP,Saxena V,Knudson KM,Schrum AG,Gil D,Daniels MA,Zamoyska R,Teixeiro E
Thu Sep 15 00:00:00 EDT 2016
STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Olson MR,Verdan FF,Hufford MM,Dent AL,Kaplan MH
Fri Apr 15 00:00:00 EDT 2016
Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Jones LL,Alli R,Li B,Geiger TL
Fri Apr 01 00:00:00 EDT 2016
Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice.
Journal of immunology (Baltimore, Md. : 1950)
Niu S,Bian Z,Tremblay A,Luo Y,Kidder K,Mansour A,Zen K,Liu Y
Sat Oct 15 00:00:00 EDT 2016
IL-10 Enhances IgE-Mediated Mast Cell Responses and Is Essential for the Development of Experimental Food Allergy in IL-10-Deficient Mice.
Journal of immunology (Baltimore, Md. : 1950)
Polukort SH,Rovatti J,Carlson L,Thompson C,Ser-Dolansky J,Kinney SR,Schneider SS,Mathias CB
Wed Jun 15 00:00:00 EDT 2016
β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage.
Journal of immunology (Baltimore, Md. : 1950)
Boucard-Jourdin M,Kugler D,Endale Ahanda ML,This S,De Calisto J,Zhang A,Mora JR,Stuart LM,Savill J,Lacy-Hulbert A,Paidassi H
Thu Sep 01 00:00:00 EDT 2016
Pancreatic Cancer Cell Exosome-Mediated Macrophage Reprogramming and the Role of MicroRNAs 155 and 125b2 Transfection using Nanoparticle Delivery Systems.
Scientific reports
Su MJ,Aldawsari H,Amiji M
Fri Jul 22 00:00:00 EDT 2016
Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche.
Nature communications
Hu X,Garcia M,Weng L,Jung X,Murakami JL,Kumar B,Warden CD,Todorov I,Chen CC
Mon Oct 10 00:00:00 EDT 2016
Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling.
The Journal of experimental medicine
Bourdonnay E,Zasłona Z,Penke LR,Speth JM,Schneider DJ,Przybranowski S,Swanson JA,Mancuso P,Freeman CM,Curtis JL,Peters-Golden M
Mon May 04 00:00:00 EDT 2015
CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer.
Proceedings of the National Academy of Sciences of the United States of America
Cheah MT,Chen JY,Sahoo D,Contreras-Trujillo H,Volkmer AK,Scheeren FA,Volkmer JP,Weissman IL
Tue Apr 14 00:00:00 EDT 2015
IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis.
Nature communications
Nakamura R,Sene A,Santeford A,Gdoura A,Kubota S,Zapata N,Apte RS
Tue Aug 11 00:00:00 EDT 2015
Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation.
Scientific reports
Gurung P,Li B,Subbarao Malireddi RK,Lamkanfi M,Geiger TL,Kanneganti TD
Mon Sep 28 00:00:00 EDT 2015
Modulation of Macrophage Functional Polarity towards Anti-Inflammatory Phenotype with Plasmid DNA Delivery in CD44 Targeting Hyaluronic Acid Nanoparticles.
Scientific reports
Tran TH,Rastogi R,Shelke J,Amiji MM
Wed Nov 18 00:00:00 EST 2015
Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis.
Immunity
Zigmond E,Bernshtein B,Friedlander G,Walker CR,Yona S,Kim KW,Brenner O,Krauthgamer R,Varol C,Müller W,Jung S
Thu May 15 00:00:00 EDT 2014
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.
Immunity
Shouval DS,Biswas A,Goettel JA,McCann K,Conaway E,Redhu NS,Mascanfroni ID,Al Adham Z,Lavoie S,Ibourk M,Nguyen DD,Samsom JN,Escher JC,Somech R,Weiss B,Beier R,Conklin LS,Ebens CL,Santos FG,Ferreira AR,Sherlock M,Bhan AK,Müller W,Mora JR,Quintana FJ,Klein C,Muise AM,Horwitz BH,Snapper SB
Thu May 15 00:00:00 EDT 2014
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
Nature immunology
Nagashima H,Okuyama Y,Asao A,Kawabe T,Yamaki S,Nakano H,Croft M,Ishii N,So T
210-10 was used in In vitro experiments to identify TRAF5 as a negative regulator of the IL-6 receptor signalling pathway that limits the induction of proinflammatory CD4(+) T cells.
Thu May 01 00:00:00 EDT 2014
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.
Proceedings of the National Academy of Sciences of the United States of America
Gobbetti T,Coldewey SM,Chen J,McArthur S,le Faouder P,Cenac N,Flower RJ,Thiemermann C,Perretti M
Tue Dec 30 00:00:00 EST 2014
Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease.
Cell death and differentiation
Tang Y,Li T,Li J,Yang J,Liu H,Zhang XJ,Le W
Sat Mar 01 00:00:00 EST 2014
Antigen-pulsed bone marrow-derived and pulmonary dendritic cells promote Th2 cell responses and immunopathology in lungs during the pathogenesis of murine Mycoplasma pneumonia.
Journal of immunology (Baltimore, Md. : 1950)
Dobbs NA,Zhou X,Pulse M,Hodge LM,Schoeb TR,Simecka JW
Fri Aug 01 00:00:00 EDT 2014
Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis.
Journal of immunology (Baltimore, Md. : 1950)
Lu N,Wang L,Cao H,Liu L,Van Kaer L,Washington MK,Rosen MJ,Dubé PE,Wilson KT,Ren X,Hao X,Polk DB,Yan F
Sat Feb 01 00:00:00 EST 2014
Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge.
Cell death & disease
Través PG,Pardo V,Pimentel-Santillana M,González-Rodríguez Á,Mojena M,Rico D,Montenegro Y,Calés C,Martín-Sanz P,Valverde AM,Boscá L
Thu Mar 13 00:00:00 EDT 2014
Mesenchymal stem cells are mobilized from the bone marrow during inflammation.
Frontiers in immunology
Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE
Wed Mar 06 00:00:00 EST 2013
Nucleotide-binding oligomerization domain 2 signaling promotes hyperresponsive macrophages and colitis in IL-10-deficient mice.
Journal of immunology (Baltimore, Md. : 1950)
Jamontt J,Petit S,Clark N,Parkinson SJ,Smith P
Fri Mar 15 00:00:00 EDT 2013
TLR activation excludes circulating naive CD8+ T cells from gut-associated lymphoid organs in mice.
Journal of immunology (Baltimore, Md. : 1950)
Heidegger S,Kirchner SK,Stephan N,Bohn B,Suhartha N,Hotz C,Anz D,Sandholzer N,Stecher B,Rüssmann H,Endres S,Bourquin C
Wed May 15 00:00:00 EDT 2013
Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Liu B,Wang M,Wang X,Zhao D,Liu D,Liu J,Chen PJ,Yang D,He F,Tang L
Mon Apr 15 00:00:00 EDT 2013
Tumor-derived vascular pericytes anergize Th cells.
Journal of immunology (Baltimore, Md. : 1950)
Bose A,Barik S,Banerjee S,Ghosh T,Mallick A,Bhattacharyya Majumdar S,Goswami KK,Bhuniya A,Banerjee S,Baral R,Storkus WJ,Dasgupta PS,Majumdar S
Mon Jul 15 00:00:00 EDT 2013
Inflammatory cytokine-mediated evasion of virus-induced tumors from NK cell control.
Journal of immunology (Baltimore, Md. : 1950)
Mishra R,Polic B,Welsh RM,Szomolanyi-Tsuda E
Mon Jul 15 00:00:00 EDT 2013
Reciprocal negative cross-talk between liver X receptors (LXRs) and STAT1: effects on IFN-γ-induced inflammatory responses and LXR-dependent gene expression.
Journal of immunology (Baltimore, Md. : 1950)
Pascual-García M,Rué L,León T,Julve J,Carbó JM,Matalonga J,Auer H,Celada A,Escolà-Gil JC,Steffensen KR,Pérez-Navarro E,Valledor AF
Sat Jun 15 00:00:00 EDT 2013
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.
The Journal of clinical investigation
Yiakouvaki A,Dimitriou M,Karakasiliotis I,Eftychi C,Theocharis S,Kontoyiannis DL
Sun Jan 01 00:00:00 EST 2012
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Vaeth M,Schliesser U,Müller G,Reissig S,Satoh K,Tuettenberg A,Jonuleit H,Waisman A,Müller MR,Serfling E,Sawitzki BS,Berberich-Siebelt F
Tue Oct 02 00:00:00 EDT 2012
Transient TLR activation restores inflammatory response and ability to control pulmonary bacterial infection in germfree mice.
Journal of immunology (Baltimore, Md. : 1950)
Fagundes CT,Amaral FA,Vieira AT,Soares AC,Pinho V,Nicoli JR,Vieira LQ,Teixeira MM,Souza DG
Wed Feb 01 00:00:00 EST 2012
Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Eberle ME,Dalpke AH
Fri Jun 01 00:00:00 EDT 2012
Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions.
Journal of immunology (Baltimore, Md. : 1950)
Bian Z,Guo Y,Ha B,Zen K,Liu Y
Sun Jan 15 00:00:00 EST 2012
Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
Poovassery JS,Bishop GA
Wed Aug 15 00:00:00 EDT 2012
IL-22 mediates host defense against an intestinal intracellular parasite in the absence of IFN-γ at the cost of Th17-driven immunopathology.
Journal of immunology (Baltimore, Md. : 1950)
Stange J,Hepworth MR,Rausch S,Zajic L,Kühl AA,Uyttenhove C,Renauld JC,Hartmann S,Lucius R
Thu Mar 01 00:00:00 EST 2012
NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950)
Souza-Fonseca-Guimaraes F,Parlato M,Fitting C,Cavaillon JM,Adib-Conquy M
Fri Jun 15 00:00:00 EDT 2012
Dynamics of the splenic innate-like CD19⁺CD45Rlo cell population from adult mice in homeostatic and activated conditions.
Journal of immunology (Baltimore, Md. : 1950)
de Andrés B,Prado C,Palacios B,Alía M,Jagtap S,Serrano N,Cortegano I,Marcos MA,Gaspar ML
Sat Sep 01 00:00:00 EDT 2012
IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Kobayashi T,Matsuoka K,Sheikh SZ,Russo SM,Mishima Y,Collins C,deZoeten EF,Karp CL,Ting JP,Sartor RB,Plevy SE
Wed Aug 15 00:00:00 EDT 2012
Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents.
PloS one
Gresa-Arribas N,Viéitez C,Dentesano G,Serratosa J,Saura J,Solà C
Thu Feb 28 00:00:00 EST 2013
TGFβ signaling plays a critical role in promoting alternative macrophage activation.
BMC immunology
Gong D,Shi W,Yi SJ,Chen H,Groffen J,Heisterkamp N
Fri Jun 15 00:00:00 EDT 2012
Toxoplasma gondii infection in the brain inhibits neuronal degeneration and learning and memory impairments in a murine model of Alzheimer's disease.
PloS one
Jung BK,Pyo KH,Shin KY,Hwang YS,Lim H,Lee SJ,Moon JH,Lee SH,Suh YH,Chai JY,Shin EH
Fri Aug 03 00:00:00 EDT 2012
Multiwalled carbon nanotubes interact with macrophages and influence tumor progression and metastasis.
Theranostics
Yang M,Meng J,Cheng X,Lei J,Guo H,Zhang W,Kong H,Xu H
Tue Oct 02 00:00:00 EDT 2012
Type I interferon inhibits interleukin-1 production and inflammasome activation.
Immunity
Guarda G,Braun M,Staehli F,Tardivel A,Mattmann C,Förster I,Farlik M,Decker T,Du Pasquier RA,Romero P,Tschopp J
Fri Feb 25 00:00:00 EST 2011
B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen.
Nature immunology
Puga I,Cols M,Barra CM,He B,Cassis L,Gentile M,Comerma L,Chorny A,Shan M,Xu W,Magri G,Knowles DM,Tam W,Chiu A,Bussel JB,Serrano S,Lorente JA,Bellosillo B,Lloreta J,Juanpere N,Alameda F,Baró T,de Heredia CD,Torán N,Català A,Torrebadell M,Fortuny C,Cusí V,Carreras C,Diaz GA,Blander JM,Farber CM,Silvestri G,Cunningham-Rundles C,Calvillo M,Dufour C,Notarangelo LD,Lougaris V,Plebani A,Casanova JL,Ganal SC,Diefenbach A,Aróstegui JI,Juan M,Yagüe J,Mahlaoui N,Donadieu J,Chen K,Cerutti A
Sun Dec 25 00:00:00 EST 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
Mon Apr 11 00:00:00 EDT 2011
Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants.
The Journal of experimental medicine
Purtha WE,Tedder TF,Johnson S,Bhattacharya D,Diamond MS
Mon Dec 19 00:00:00 EST 2011
p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair.
The Journal of cell biology
Perdiguero E,Sousa-Victor P,Ruiz-Bonilla V,Jardí M,Caelles C,Serrano AL,Muñoz-Cánoves P
Mon Oct 17 00:00:00 EDT 2011
A Salmonella Typhimurium-Typhi genomic chimera: a model to study Vi polysaccharide capsule function in vivo.
PLoS pathogens
Jansen AM,Hall LJ,Clare S,Goulding D,Holt KE,Grant AJ,Mastroeni P,Dougan G,Kingsley RA
Fri Jul 01 00:00:00 EDT 2011
The phosphatase SRC homology region 2 domain-containing phosphatase-1 is an intrinsic central regulator of dendritic cell function.
Journal of immunology (Baltimore, Md. : 1950)
Ramachandran IR,Song W,Lapteva N,Seethammagari M,Slawin KM,Spencer DM,Levitt JM
Fri Apr 01 00:00:00 EDT 2011
Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component.
Journal of immunology (Baltimore, Md. : 1950)
Zhang W,Xu W,Xiong S
Mon Aug 15 00:00:00 EDT 2011
DAP12 promotes IRAK-M expression and IL-10 production by liver myeloid dendritic cells and restrains their T cell allostimulatory ability.
Journal of immunology (Baltimore, Md. : 1950)
Sumpter TL,Packiam V,Turnquist HR,Castellaneta A,Yoshida O,Thomson AW
Tue Feb 15 00:00:00 EST 2011
An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis.
Journal of immunology (Baltimore, Md. : 1950)
Sheikh SZ,Hegazi RA,Kobayashi T,Onyiah JC,Russo SM,Matsuoka K,Sepulveda AR,Li F,Otterbein LE,Plevy SE
Sun May 01 00:00:00 EDT 2011
IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression.
Journal of immunology (Baltimore, Md. : 1950)
Xu Y,Schnorrer P,Proietto A,Kowalski G,Febbraio MA,Acha-Orbea H,Dickins RA,Villadangos JA
Tue Mar 15 00:00:00 EDT 2011
Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.
PloS one
Takeuchi H,Yokota A,Ohoka Y,Iwata M
Fri Jan 07 00:00:00 EST 2011
Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance.
Nature communications
Chinen T,Komai K,Muto G,Morita R,Inoue N,Yoshida H,Sekiya T,Yoshida R,Nakamura K,Takayanagi R,Yoshimura A
Tue Feb 08 00:00:00 EST 2011
Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells.
The Journal of biological chemistry
Palmer MT,Lee YK,Maynard CL,Oliver JR,Bikle DD,Jetten AM,Weaver CT
Fri Jan 14 00:00:00 EST 2011
Deletion of the aryl hydrocarbon receptor enhances the inflammatory response to Leishmania major infection.
International journal of biological sciences
Elizondo G,Rodríguez-Sosa M,Estrada-Muñiz E,Gonzalez FJ,Vega L
Tue May 29 00:00:00 EDT 2012
CD11c depletion severely disrupts Th2 induction and development in vivo.
The Journal of experimental medicine
Phythian-Adams AT,Cook PC,Lundie RJ,Jones LH,Smith KA,Barr TA,Hochweller K,Anderton SM,Hämmerling GJ,Maizels RM,MacDonald AS
Mon Sep 27 00:00:00 EDT 2010
Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation.
PLoS pathogens
Haldar AK,Yadav V,Singhal E,Bisht KK,Singh A,Bhaumik S,Basu R,Sen P,Roy S
Thu May 20 00:00:00 EDT 2010
The highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Fernández de Marco Mdel M,Alejo A,Hudson P,Damon IK,Alcami A
Sat May 01 00:00:00 EDT 2010
Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function.
Journal of immunology (Baltimore, Md. : 1950)
Melillo JA,Song L,Bhagat G,Blazquez AB,Plumlee CR,Lee C,Berin C,Reizis B,Schindler C
Mon Mar 01 00:00:00 EST 2010
The interactions of multiple cytokines control NK cell maturation.
Journal of immunology (Baltimore, Md. : 1950)
Brady J,Carotta S,Thong RP,Chan CJ,Hayakawa Y,Smyth MJ,Nutt SL
Wed Dec 01 00:00:00 EST 2010
Tumor cell-released TLR4 ligands stimulate Gr-1+CD11b+F4/80+ cells to induce apoptosis of activated T cells.
Journal of immunology (Baltimore, Md. : 1950)
Liu YY,Sun LC,Wei JJ,Li D,Yuan Y,Yan B,Liang ZH,Zhu HF,Xu Y,Li B,Song CW,Liao SJ,Lei Z,Zhang GM,Feng ZH
Wed Sep 01 00:00:00 EDT 2010
Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation.
Journal of immunology (Baltimore, Md. : 1950)
Rodríguez-Prados JC,Través PG,Cuenca J,Rico D,Aragonés J,Martín-Sanz P,Cascante M,Boscá L
Thu Jul 01 00:00:00 EDT 2010
Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.
Journal of neuroinflammation
Dohi K,Ohtaki H,Nakamachi T,Yofu S,Satoh K,Miyamoto K,Song D,Tsunawaki S,Shioda S,Aruga T
Mon Jul 26 00:00:00 EDT 2010
The inhibitory effect against collagen-induced arthritis by Schistosoma japonicum infection is infection stage-dependent.
BMC immunology
He Y,Li J,Zhuang W,Yin L,Chen C,Li J,Chi F,Bai Y,Chen XP
Thu Jun 10 00:00:00 EDT 2010
Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines.
PLoS neglected tropical diseases
Zhang S,Kim CC,Batra S,McKerrow JH,Loke P
Tue Mar 30 00:00:00 EDT 2010
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.
Cancer cell
DeNardo DG,Barreto JB,Andreu P,Vasquez L,Tawfik D,Kolhatkar N,Coussens LM
Tue Aug 04 00:00:00 EDT 2009
Negative regulation of MyD88-dependent signaling by IL-10 in dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
Chang J,Kunkel SL,Chang CH
Tue Oct 27 00:00:00 EDT 2009
Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages.
Journal of leukocyte biology
Choi BS,Martinez-Falero IC,Corset C,Munder M,Modolell M,Müller I,Kropf P
Sun Feb 01 00:00:00 EST 2009
Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways.
Journal of immunology (Baltimore, Md. : 1950)
Aleyas AG,George JA,Han YW,Rahman MM,Kim SJ,Han SB,Kim BS,Kim K,Eo SK
Sat Aug 15 00:00:00 EDT 2009
Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock.
Journal of immunology (Baltimore, Md. : 1950)
Jung ID,Lee MG,Chang JH,Lee JS,Jeong YI,Lee CM,Park WS,Han J,Seo SK,Lee SY,Park YM
Sun Mar 01 00:00:00 EST 2009
Interaction of adipocyte fatty acid-binding protein (AFABP) and JAK2: AFABP/aP2 as a regulator of JAK2 signaling.
The Journal of biological chemistry
Thompson BR,Mazurkiewicz-Muñoz AM,Suttles J,Carter-Su C,Bernlohr DA
Fri May 15 00:00:00 EDT 2009
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.
Immunity
Hill JA,Hall JA,Sun CM,Cai Q,Ghyselinck N,Chambon P,Belkaid Y,Mathis D,Benoist C
Fri Nov 14 00:00:00 EST 2008
Bone marrow-derived dendritic cells generated in the presence of resolvin E1 induce apoptosis of activated CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Vassiliou EK,Kesler OM,Tadros JH,Ganea D
Wed Oct 01 00:00:00 EDT 2008
Regulation of alternative macrophage activation by galectin-3.
Journal of immunology (Baltimore, Md. : 1950)
MacKinnon AC,Farnworth SL,Hodkinson PS,Henderson NC,Atkinson KM,Leffler H,Nilsson UJ,Haslett C,Forbes SJ,Sethi T
Fri Feb 15 00:00:00 EST 2008
CXCL10 blockade protects mice from cyclophosphamide-induced cystitis.
Journal of immune based therapies and vaccines
Sakthivel SK,Singh UP,Singh S,Taub DD,Novakovic KR,Lillard JW
Tue Oct 28 00:00:00 EDT 2008
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B
Sat Dec 15 00:00:00 EST 2007
Beneficial autoimmunity to proinflammatory mediators restrains the consequences of self-destructive immunity.
Immunity
Wildbaum G,Nahir MA,Karin N
Sat Nov 01 00:00:00 EST 2003
Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis.
European journal of immunology
Krajina T,Leithäuser F,Möller P,Trobonjaca Z,Reimann J
210-10 was used in Cell Culture to investigate immune activation in colonic lamina propria.
Tue Apr 01 00:00:00 EST 2003
Delineation of five thyroglobulin T cell epitopes with pathogenic potential in experimental autoimmune thyroiditis.
Journal of immunology (Baltimore, Md. : 1950)
Verginis P,Stanford MM,Carayanniotis G
Fri Nov 01 00:00:00 EST 2002
