Product References
A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression.
Development (Cambridge, England)
Vrij EJ,Scholte Op Reimer YS,Roa Fuentes L,Misteli Guerreiro I,Holzmann V,Frias Aldeguer J,Sestini G,Koo BK,Kind J,van Blitterswijk CA,Rivron NC
220-11 was used in In vitro experiments to create a partial mouse embryo model to elucidate the principles of epiblast (Epi) and extra-embryonic endoderm co-development (XEn) to suggest that self-organization can arise from lineage bifurcation followed by a pendulum of induction that propagates over time.
Sat Oct 15 00:00:00 EDT 2022
Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.
The Journal of experimental medicine
Cova G,Taroni C,Deau MC,Cai Q,Mittelheisser V,Philipps M,Jung M,Cerciat M,Le Gras S,Thibault-Carpentier C,Jost B,Carlsson L,Thornton AM,Shevach EM,Kirstetter P,Kastner P,Chan S
Mon Oct 04 00:00:00 EDT 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Mon Jul 05 00:00:00 EDT 2021
Intranasal mesenchymal stem cell therapy to boost myelination after encephalopathy of prematurity.
Glia
Vaes JEG,van Kammen CM,Trayford C,van der Toorn A,Ruhwedel T,Benders MJNL,Dijkhuizen RM,Möbius W,van Rijt SH,Nijboer CH
220-11 was used in Cell Culture to show that MSCs adapt their secretome after ex vivo exposure to dWMI milieu and identified several factors including IGF1, EGF, LIF, and IL11 that potently boost OL maturation.
Mon Mar 01 00:00:00 EST 2021
Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.
Blood
Numata A,Kwok HS,Zhou QL,Li J,Tirado-Magallanes R,Angarica VE,Hannah R,Park J,Wang CQ,Krishnan V,Rajagopalan D,Zhang Y,Zhou S,Welner RS,Osato M,Jha S,Bohlander SK,Göttgens B,Yang H,Benoukraf T,Lough JW,Bararia D,Tenen DG
Thu Oct 08 00:00:00 EDT 2020
Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells.
Cell stem cell
Murata K,Jadhav U,Madha S,van Es J,Dean J,Cavazza A,Wucherpfennig K,Michor F,Clevers H,Shivdasani RA
220-11 was used in Cell Culture to study the transcriptional and signaling trajectories that guide the differentiation of different intestinal crypt populations to provide new intestinal stem cells (ISCs).
Thu Mar 05 00:00:00 EST 2020
Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells.
Cell stem cell
Murata K,Jadhav U,Madha S,van Es J,Dean J,Cavazza A,Wucherpfennig K,Michor F,Clevers H,Shivdasani RA
220-11 was used in Cell Culture to study the transcriptional and signaling trajectories that guide the differentiation of different intestinal crypt populations to provide new intestinal stem cells (ISCs).
Thu Mar 05 00:00:00 EST 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Mon Mar 02 00:00:00 EST 2020
Gut microbiota regulate tumor metastasis via circRNA/miRNA networks.
Gut microbes
Zhu Z,Huang J,Li X,Xing J,Chen Q,Liu R,Hua F,Qiu Z,Song Y,Bai C,Mo YY,Zhang Z
220-11 was used in In vivo experiments to investigate gut microbiota on microRNA influence on cancer progression.
Mon Nov 09 00:00:00 EST 2020
Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.
Science advances
Pessoa Rodrigues C,Herman JS,Herquel B,Valsecchi CIK,Stehle T,Grün D,Akhtar A
220-11 was used in In vitro experiments to study the mechanism by which histone H4 lysine 16 acetyltransferase MOF regulates erythropoiesis.
Fri May 01 00:00:00 EDT 2020
Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.
Nature communications
Oatley M,Bölükbası ÖV,Svensson V,Shvartsman M,Ganter K,Zirngibl K,Pavlovich PV,Milchevskaya V,Foteva V,Natarajan KN,Baying B,Benes V,Patil KR,Teichmann SA,Lancrin C
Wed Jan 29 00:00:00 EST 2020
IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Zhang X,Kiapour N,Kapoor S,Khan T,Thamilarasan M,Tao Y,Cohen S,Miller R,Sobel RA,Markovic-Plese S
Sun Sep 01 00:00:00 EDT 2019
Population snapshots predict early haematopoietic and erythroid hierarchies.
Nature
Tusi BK,Wolock SL,Weinreb C,Hwang Y,Hidalgo D,Zilionis R,Waisman A,Huh JR,Klein AM,Socolovsky M
220-11 was used in In vitro experiments to illustrate the utility of coupling population snapshots with predictive fate models, to gain in vivo insights of early hempatopoetic and erythroid lineage sorting.
Thu Mar 01 00:00:00 EST 2018
Clonal analysis of lineage fate in native haematopoiesis.
Nature
Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD
Thu Jan 11 00:00:00 EST 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
Tue Apr 17 00:00:00 EDT 2018
Kinetics of adult hematopoietic stem cell differentiation in vivo.
The Journal of experimental medicine
Upadhaya S,Sawai CM,Papalexi E,Rashidfarrokhi A,Jang G,Chattopadhyay P,Satija R,Reizis B
Mon Nov 05 00:00:00 EST 2018
In Vitro Differentiation of Gata2 and Ly6a Reporter Embryonic Stem Cells Corresponds to In Vivo Waves of Hematopoietic Cell Generation.
Stem cell reports
Kauts ML,Rodriguez-Seoane C,Kaimakis P,Mendes SC,Cortés-Lavaud X,Hill U,Dzierzak E
Tue Jan 09 00:00:00 EST 2018
Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow.
Stem cell reports
Karatepe K,Zhu H,Zhang X,Guo R,Kambara H,Loison F,Liu P,Yu H,Ren Q,Luo X,Manis J,Cheng T,Ma F,Xu Y,Luo HR
Tue Nov 13 00:00:00 EST 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
Tue Oct 09 00:00:00 EDT 2018
MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
Cancer cell
Chen Y,Anastassiadis K,Kranz A,Stewart AF,Arndt K,Waskow C,Yokoyama A,Jones K,Neff T,Lee Y,Ernst P
Mon Jun 12 00:00:00 EDT 2017
Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.
Cancer cell
Poh AR,Love CG,Masson F,Preaudet A,Tsui C,Whitehead L,Monard S,Khakham Y,Burstroem L,Lessene G,Sieber O,Lowell C,Putoczki TL,O'Donoghue RJJ,Ernst M
Mon Apr 10 00:00:00 EDT 2017
Osteoblasts support megakaryopoiesis through production of interleukin-9.
Blood
Xiao M,Wang Y,Tao C,Wang Z,Yang J,Chen Z,Zou Z,Li M,Liu A,Jia C,Huang B,Yan B,Lai P,Ding C,Cai D,Xiao G,Jiang Y,Bai X
Thu Jun 15 00:00:00 EDT 2017
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.
The Journal of experimental medicine
Öhlund D,Handly-Santana A,Biffi G,Elyada E,Almeida AS,Ponz-Sarvise M,Corbo V,Oni TE,Hearn SA,Lee EJ,Chio II,Hwang CI,Tiriac H,Baker LA,Engle DD,Feig C,Kultti A,Egeblad M,Fearon DT,Crawford JM,Clevers H,Park Y,Tuveson DA
Mon Mar 06 00:00:00 EST 2017
Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity.
Journal of lipid research
Sun S,Wang R,Song J,Guan M,Li N,Zhang X,Zhao Z,Zhang J
Wed Nov 01 00:00:00 EDT 2017
EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Scientific reports
Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G
220-11 was used in Tissue/organ culture to identify EphrinB2 as an essential regulator of adult haematopoiesis but not generation of endothelial cells.
Thu Jun 02 00:00:00 EDT 2016
Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche.
Nature communications
Hu X,Garcia M,Weng L,Jung X,Murakami JL,Kumar B,Warden CD,Todorov I,Chen CC
Mon Oct 10 00:00:00 EDT 2016
Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN.
Blood
Grisouard J,Shimizu T,Duek A,Kubovcakova L,Hao-Shen H,Dirnhofer S,Skoda RC
Thu Mar 26 00:00:00 EDT 2015
Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.
The Journal of clinical investigation
Duque-Afonso J,Feng J,Scherer F,Lin CH,Wong SH,Wang Z,Iwasaki M,Cleary ML
Tue Sep 01 00:00:00 EDT 2015
Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.
The Journal of experimental medicine
Xia P,Wang S,Du Y,Huang G,Satoh T,Akira S,Fan Z
Mon Dec 14 00:00:00 EST 2015
Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system.
Glia
Grill M,Syme TE,Noçon AL,Lu AZ,Hancock D,Rose-John S,Campbell IL
Thu Oct 01 00:00:00 EDT 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
Mon Oct 12 00:00:00 EDT 2015
Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury.
Scientific reports
Lin W,Yuan N,Wang Z,Cao Y,Fang Y,Li X,Xu F,Song L,Wang J,Zhang H,Yan L,Xu L,Zhang X,Zhang S,Wang J
Tue Jul 21 00:00:00 EDT 2015
Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.
The Journal of experimental medicine
Lancini C,van den Berk PC,Vissers JH,Gargiulo G,Song JY,Hulsman D,Serresi M,Tanger E,Blom M,Vens C,van Lohuizen M,Jacobs H,Citterio E
Mon Aug 25 00:00:00 EDT 2014
Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.
The Journal of experimental medicine
Pietras EM,Lakshminarasimhan R,Techner JM,Fong S,Flach J,Binnewies M,Passegué E
Mon Feb 10 00:00:00 EST 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Mon Sep 22 00:00:00 EDT 2014
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Nature
Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E
Thu Feb 21 00:00:00 EST 2013
Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling.
Blood
Malinge S,Thiollier C,Chlon TM,Doré LC,Diebold L,Bluteau O,Mabialah V,Vainchenker W,Dessen P,Winandy S,Mercher T,Crispino JD
Thu Mar 28 00:00:00 EDT 2013
Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice.
Blood
Schepers K,Hsiao EC,Garg T,Scott MJ,Passegué E
Thu Oct 25 00:00:00 EDT 2012
Induction of histiocytic sarcoma in mouse skeletal muscle.
PloS one
Liu J,Hettmer S,Milsom MD,Hofmann I,Hua F,Miller C,Bronson RT,Wagers AJ
Thu Feb 07 00:00:00 EST 2013
Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.
Blood
Cornejo MG,Mabialah V,Sykes SM,Khandan T,Lo Celso C,Lopez CK,Rivera-Muñoz P,Rameau P,Tothova Z,Aster JC,DePinho RA,Scadden DT,Gilliland DG,Mercher T
Thu Aug 04 00:00:00 EDT 2011
Inhibitory effects of megakaryocytic cells in prostate cancer skeletal metastasis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Li X,Koh AJ,Wang Z,Soki FN,Park SI,Pienta KJ,McCauley LK
Sat Jan 01 00:00:00 EST 2011
The transcription factor Srf regulates hematopoietic stem cell adhesion.
Blood
Ragu C,Elain G,Mylonas E,Ottolenghi C,Cagnard N,Daegelen D,Passegué E,Vainchenker W,Bernard OA,Penard-Lacronique V
Thu Nov 25 00:00:00 EST 2010
Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate.
Blood
Chou ST,Khandros E,Bailey LC,Nichols KE,Vakoc CR,Yao Y,Huang Z,Crispino JD,Hardison RC,Blobel GA,Weiss MJ
Thu Jul 30 00:00:00 EDT 2009
The adhesion molecule esam1 is a novel hematopoietic stem cell marker.
Stem cells (Dayton, Ohio)
Ooi AG,Karsunky H,Majeti R,Butz S,Vestweber D,Ishida T,Quertermous T,Weissman IL,Forsberg EC
Sun Mar 01 00:00:00 EST 2009
IL-11 regulates autoimmune demyelination.
Journal of immunology (Baltimore, Md. : 1950)
Gurfein BT,Zhang Y,López CB,Argaw AT,Zameer A,Moran TM,John GR
Thu Oct 01 00:00:00 EDT 2009
Nuclear factor of activated T cells (NFAT) mediates CD154 expression in megakaryocytes.
Blood
Crist SA,Sprague DL,Ratliff TL
Tue Apr 01 00:00:00 EDT 2008
TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice.
Blood
Zhou Y,Du W,Koretsky T,Bagby GC,Pang Q
Mon Sep 15 00:00:00 EDT 2008
E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Yang Q,Kardava L,St Leger A,Martincic K,Varnum-Finney B,Bernstein ID,Milcarek C,Borghesi L
Sat Nov 01 00:00:00 EDT 2008
PECAM-1: a multifaceted regulator of megakaryocytopoiesis.
Blood
Wu Y,Welte T,Michaud M,Madri JA
Wed Aug 01 00:00:00 EDT 2007
TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.
The Journal of clinical investigation
Li J,Sejas DP,Zhang X,Qiu Y,Nattamai KJ,Rani R,Rathbun KR,Geiger H,Williams DA,Bagby GC,Pang Q
Thu Nov 01 00:00:00 EDT 2007
