Gibco

Mouse IL-12 p70 Recombinant Protein, PeproTech®

Mouse IL-12 p70 Protein in Functional Assay (Functional)

FIGURE: 1 / 1

Mouse IL-12 p70 Protein (210-12-10UG) in Functional

Bioassay analysis of Mouse IL-12 p70 Recombinant Protein, PeproTech® (Product # 210-12-1MG).

Product Image Gallery

Product Details

210-12-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

Flow Cytometry (Flow)

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

View 6 publications 6 publications

Neutralization (Neu)

View 2 publications 2 publications

Functional Assay (Functional)

Assay-dependent

View 2 publications 2 publications

In vitro Assay (IV)

View 337 publications 337 publications

Miscellaneous PubMed (Misc)

View 45 publications 45 publications

Immunostaining (IS)

View 1 publication 1 publication

Product Specifications

Species

Mouse

Published species

Bovine, Human, Mouse

Expression System

CHO cells

Amino acid sequence

p35 subunit: RVIPVSGPAR CLSQSRNLLK TTDDMVKTAR EKLKHYSCTA EDIDHEDITR DQTSTLKTCL PLELHKNESC LATRETSSTT RGSCLPPQKT SLMMTLCLGS IYEDLKMYQT EFQAINAALQ NHNHQQIILD KGMLVAIDEL MQSLNHNGET LRQKPPVGEA DPYRVKMKLC ILLHAFSTRV VTINRVMGYL SSA p40 subunit: MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS

Molecular weight

75 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to induce cell proliferation in T-cell enriched PBMCs. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

210-12-1MG will be provided as 2 x 500 µg (210-12-500UG).

Recombinant Murine IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (506 total amino acid residues).

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

IL-12 p70, also known as interleukin-12, is a cytokine that plays a critical role in the immune system's response to infections and cancer. It is produced by immune cells, including dendritic cells, macrophages, and B cells, in response to certain pathogens and tumor cells. IL-12 p70 stimulates the production of interferon-gamma and other cytokines, which promote the activation and proliferation of T cells and natural killer cells. IL-12 p70 has been studied as a potential therapeutic target for various diseases and conditions, including infectious diseases, autoimmune disorders, and cancer. It has been shown to enhance immune responses against certain infections and tumors, and to modulate inflammatory responses in autoimmune diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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210-12 was used in Cell Culture to reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea.

Tue Nov 07 00:00:00 EST 2023

Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction.

Signal transduction and targeted therapy

Wang Z,Zeng FL,Hu YW,Wang XY,Zhao FL,Zhou P,Hu J,Xiao YY,Hu ZL,Guo MF,Wei XQ,Liu X,Huang NY,Zhang J,Chen SW,Cheng J,Zheng HP,Zhou H,Zhao QX,Zhang C,Hao Y,Zou S,Gui YY,Yu JD,Gu LN,Yue CC,Zhang HZ,Wu WL,Zhou YF,Zhou XK,Shen GB,Teng X,Li J

Thu Jan 20 00:00:00 EST 2022

The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.

The Journal of experimental medicine

Krzywinska E,Sobecki M,Nagarajan S,Zacharjasz J,Tambuwala MM,Pelletier A,Cummins E,Gotthardt D,Fandrey J,Kerdiles YM,Peyssonnaux C,Taylor CT,Sexl V,Stockmann C

Mon Feb 07 00:00:00 EST 2022

The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.

The Journal of experimental medicine

Krzywinska E,Sobecki M,Nagarajan S,Zacharjasz J,Tambuwala MM,Pelletier A,Cummins E,Gotthardt D,Fandrey J,Kerdiles YM,Peyssonnaux C,Taylor CT,Sexl V,Stockmann C

Mon Feb 07 00:00:00 EST 2022

Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.

EMBO molecular medicine

Letizia M,Wang YH,Kaufmann U,Gerbeth L,Sand A,Brunkhorst M,Weidner P,Ziegler JF,Böttcher C,Schlickeiser S,Fernández C,Yamashita M,Stauderman K,Sun K,Kunkel D,Prakriya M,Sanders A,Siegmund B,Feske S,Weidinger C

210-12 was used in Sample Preparation (FC/FACS) to indicate that SOCE inhibition may be a suitable new approach for the treatment of IBD.

Wed Sep 07 00:00:00 EDT 2022

The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα⁺ intraepithelial lymphocyte precursors.

Nature immunology

Nie J,Carpenter AC,Chopp LB,Chen T,Balmaceno-Criss M,Ciucci T,Xiao Q,Kelly MC,McGavern DB,Belkaid Y,Bosselut R

210-12 was used in Cell Culture to identify LRF as an essential transcriptional regulator of IELp maturation in the thymus and subsequent migration to the intestinal epithelium.

Fri Apr 01 00:00:00 EDT 2022

CNS Pericytes Modulate Local T Cell Infiltration in EAE.

International journal of molecular sciences

Koch K,Lindner M,Fleck AK,Liebmann M,Eschborn M,Zondler L,Diéguez-Hurtado R,Adams RH,Meyer Zu Hörste G,Zarbock A,Kuhlmann T,Wiendl H,Klotz L

210-12 was used in In vitro experiments to find that pericytes present antigen in vitro to induce T cell activation and proliferation.

Fri Oct 28 00:00:00 EDT 2022

Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection.

PLoS pathogens

Lee AJ,Feng E,Chew MV,Balint E,Poznanski SM,Giles E,Zhang A,Marzok A,Revill SD,Vahedi F,Dubey A,Ayaub E,Jimenez-Saiz R,McGrath JJC,Ritchie TM,Jordana M,Jonigk DD,Ackermann M,Ask K,Miller M,Richards CD,Ashkar AA

210-12 was used in In vivo experiments to demonstrate that IFNs inhibit macrophage-mediated MMP production to prevent virus-induced immunopathology and uncover MMPs as a therapeutic target towards viral infections.

Sun May 01 00:00:00 EDT 2022

Evaluation of Glutaminolysis in T Cells.

Current protocols

Tajima M,Strober W

210-12 was used in Cell Culture to provide one element of such tracking by describing protocols for the assessment of the contribution of glutaminolysis to overall ATP production within different T cell subsets.

Thu Sep 01 00:00:00 EDT 2022

Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.

Nature communications

Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L

210-12 was used in In vitro experiments to demonstrate that Lin28B promotes lung metastasis of breast cancer by building an immune-suppressive pre-metastatic niche.

Wed Feb 16 00:00:00 EST 2022

Polyamine metabolism is a central determinant of helper T cell lineage fidelity.

Cell

Puleston DJ,Baixauli F,Sanin DE,Edwards-Hicks J,Villa M,Kabat AM,Kamiński MM,Stanckzak M,Weiss HJ,Grzes KM,Piletic K,Field CS,Corrado M,Haessler F,Wang C,Musa Y,Schimmelpfennig L,Flachsmann L,Mittler G,Yosef N,Kuchroo VK,Buescher JM,Balabanov S,Pearce EJ,Green DR,Pearce EL

210-12 was used in Cell Culture to conclude that polyamine metabolism is critical for maintaining the epigenome to focus TH cell subset fidelity.

Thu Aug 05 00:00:00 EDT 2021

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T

Tue Jan 12 00:00:00 EST 2021

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

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Tue Jan 12 00:00:00 EST 2021

Cold exposure protects from neuroinflammation through immunologic reprogramming.

Cell metabolism

Spiljar M,Steinbach K,Rigo D,Suárez-Zamorano N,Wagner I,Hadadi N,Vincenti I,Page N,Klimek B,Rochat MA,Kreutzfeldt M,Chevalier C,Stojanović O,Bejuy O,Colin D,Mack M,Cansever D,Greter M,Merkler D,Trajkovski M

Tue Nov 02 00:00:00 EDT 2021

Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity.

Nature immunology

Fiancette R,Finlay CM,Willis C,Bevington SL,Soley J,Ng STH,Baker SM,Andrews S,Hepworth MR,Withers DR

Fri Oct 01 00:00:00 EDT 2021

Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.

Cellular & molecular immunology

Permanyer M,Bošnjak B,Glage S,Friedrichsen M,Floess S,Huehn J,Patzer GE,Odak I,Eckert N,Zargari R,Ospina-Quintero L,Georgiev H,Förster R

Mon Feb 01 00:00:00 EST 2021

The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.

The Journal of experimental medicine

Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL

Mon Jun 07 00:00:00 EDT 2021

Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity.

The Journal of experimental medicine

Xiao Y,Qureischi M,Dietz L,Vaeth M,Vallabhapurapu SD,Klein-Hessling S,Klein M,Liang C,König A,Serfling E,Mottok A,Bopp T,Rosenwald A,Buttmann M,Berberich I,Beilhack A,Berberich-Siebelt F

Mon Jan 04 00:00:00 EST 2021

BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapy.

The Journal of experimental medicine

Pei S,Huang M,Huang J,Zhu X,Wang H,Romano S,Deng X,Wang Y,Luo Y,Hao S,Xu J,Yu T,Zhu Q,Yuan J,Shen K,Liu Z,Hu G,Peng C,Luo Q,Wen Z,Dai D,Xiao Y

Mon Jul 05 00:00:00 EDT 2021

Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.

The Journal of experimental medicine

Sasai M,Ma JS,Okamoto M,Nishino K,Nagaoka H,Takashima E,Pradipta A,Lee Y,Kosako H,Suh PG,Yamamoto M

Mon Jul 05 00:00:00 EDT 2021

Arkadia-SKI/SnoN signaling differentially regulates TGF-β-induced iTreg and Th17 cell differentiation.

The Journal of experimental medicine

Xu H,Wu L,Nguyen HH,Mesa KR,Raghavan V,Episkopou V,Littman DR

Mon Nov 01 00:00:00 EDT 2021

Mechanical force-driven TNFα endocytosis governs stem cell homeostasis.

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Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis.

Proceedings of the National Academy of Sciences of the United States of America

Ducimetière L,Lucchiari G,Litscher G,Nater M,Heeb L,Nuñez NG,Wyss L,Burri D,Vermeer M,Gschwend J,Moor AE,Becher B,van den Broek M,Tugues S

Tue Jul 06 00:00:00 EDT 2021

Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.

Aging cell

Webb LMC,Fra-Bido S,Innocentin S,Matheson LS,Attaf N,Bignon A,Novarino J,Fazilleau N,Linterman MA

Fri Jan 01 00:00:00 EST 2021

miR-99a regulates CD4⁺ T cell differentiation and attenuates experimental autoimmune encephalomyelitis by mTOR-mediated glycolysis.

Molecular therapy. Nucleic acids

Gu Y,Zhou H,Yu H,Yang W,Wang B,Qian F,Cheng Y,He S,Zhao X,Zhu L,Zhang Y,Jin M,Lu E

Fri Dec 03 00:00:00 EST 2021

Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β.

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Jang YS,Song HE,Seo GY,Jo HJ,Park S,Park HW,Kim TG,Kang SG,Yoon SI,Ko HJ,Lee GS,Park SR,Kim PH

Mon Nov 15 00:00:00 EST 2021

Purinergic Receptor P2Y₆ Is a Negative Regulator of NK Cell Maturation and Function.

Journal of immunology (Baltimore, Md. : 1950)

Li Z,Gao Y,He C,Wei H,Zhang J,Zhang H,Hu L,Jiang W

Wed Sep 15 00:00:00 EDT 2021

The Loss of H3K27 Histone Demethylase Utx in T Cells Aggravates Allergic Contact Dermatitis.

Journal of immunology (Baltimore, Md. : 1950)

Inoue T,Omori-Miyake M,Maruyama S,Okabe M,Kuwahara M,Honda H,Miura H,Yamashita M

Mon Nov 01 00:00:00 EDT 2021

Reevaluation of NOD/SCID Mice as NK Cell-Deficient Models.

BioMed research international

Miao M,Masengere H,Yu G,Shan F

Thu Jan 20 00:00:00 EST 2022

Histone deacetylase 3 represses cholesterol efflux during CD4⁺ T-cell activation.

eLife

Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS

210-12 was used in In vitro experiments to demonstrate HDAC3 is essential during CD4+ T-cell activation to repress cholesterol efflux.

Thu Dec 02 00:00:00 EST 2021

ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.

Cell reports

Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J

Tue Aug 24 00:00:00 EDT 2021

Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.

Nature communications

He J,Shangguan X,Zhou W,Cao Y,Zheng Q,Tu J,Hu G,Liang Z,Jiang C,Deng L,Wang S,Yang W,Zuo Y,Ma J,Cai R,Chen Y,Fan Q,Dong B,Xue W,Tan H,Qi Y,Gu J,Su B,Eugene Chin Y,Chen G,Wang Q,Wang T,Cheng J

Fri Jul 16 00:00:00 EDT 2021

Tumour-targeted interleukin-12 and entinostat combination therapy improves cancer survival by reprogramming the tumour immune cell landscape.

Nature communications

Hicks KC,Chariou PL,Ozawa Y,Minnar CM,Knudson KM,Meyer TJ,Bian J,Cam M,Schlom J,Gameiro SR

Thu Aug 26 00:00:00 EDT 2021

Chronic stress physically spares but functionally impairs innate-like invariant T cells.

Cell reports

Rudak PT,Choi J,Parkins KM,Summers KL,Jackson DN,Foster PJ,Skaro AI,Leslie K,McAlister VC,Kuchroo VK,Inoue W,Lantz O,Haeryfar SMM

Tue Apr 13 00:00:00 EDT 2021

Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.

Nature communications

Papaioannou NE,Salei N,Rambichler S,Ravi K,Popovic J,Küntzel V,Lehmann CHK,Fiancette R,Salvermoser J,Gajdasik DW,Mettler R,Messerer D,Carrelha J,Ohnmacht C,Haller D,Stumm R,Straub T,Jacobsen SEW,Schulz C,Withers DR,Schotta G,Dudziak D,Schraml BU

Tue Jan 19 00:00:00 EST 2021

METTL3-mediated m⁶A RNA methylation promotes the anti-tumour immunity of natural killer cells.

Nature communications

Song H,Song J,Cheng M,Zheng M,Wang T,Tian S,Flavell RA,Zhu S,Li HB,Ding C,Wei H,Sun R,Peng H,Tian Z

Fri Sep 17 00:00:00 EDT 2021

A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation.

eLife

Kiritsy MC,Ankley LM,Trombley J,Huizinga GP,Lord AE,Orning P,Elling R,Fitzgerald KA,Olive AJ

210-12 was used in Cell Culture to demonstrate regulation of MHCII expression that is required to control CD4+ T cell responses.

Mon Nov 08 00:00:00 EST 2021

Endothelial STING controls T cell transmigration in an IFNI-dependent manner.

JCI insight

Anastasiou M,Newton GA,Kaur K,Carrillo-Salinas FJ,Smolgovsky SA,Bayer AL,Ilyukha V,Sharma S,Poltorak A,Luscinskas FW,Alcaide P

210-12 was used in In vitro experiments to investigate IFN signalling effect on T cell transdoepithelial infiltration.

Mon Aug 09 00:00:00 EDT 2021

In Vivo Induction of Regulatory T Cells Via CTLA-4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Kim GR,Kim WJ,Lim S,Lee HG,Koo JH,Nam KH,Kim SM,Park SD,Choi JM

Thu Jul 01 00:00:00 EDT 2021

"γδT Cell-IL17A-Neutrophil" Axis Drives Immunosuppression and Confers Breast Cancer Resistance to High-Dose Anti-VEGFR2 Therapy.

Frontiers in immunology

Zhang Z,Yang C,Li L,Zhu Y,Su K,Zhai L,Wang Z,Huang J

210-12 was used in Sample Preparation (FC/FACS) to study cancer cell resistance to anti-VEGFR2 therapy to illustrate the potential mechanism of antiangiogenic therapy resistance in breast cancer for treatment of cancer.

Mon Dec 13 00:00:00 EST 2021

STAT4 is expressed in neutrophils and promotes antimicrobial immunity.

JCI insight

Mehrpouya-Bahrami P,Moriarty AK,De Melo P,Keeter WC,Alakhras NS,Nelson AS,Hoover M,Barrios MS,Nadler JL,Serezani CH,Kaplan MH,Galkina EV

210-12 was used in Sample Preparation (Western Blotting)g to investigate STAT4 on the differentiation of T helper 1 cells.

Thu Jul 22 00:00:00 EDT 2021

TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.

Nature communications

Yabe R,Chung SH,Murayama MA,Kubo S,Shimizu K,Akahori Y,Maruhashi T,Seno A,Kaifu T,Saijo S,Iwakura Y

Mon Jan 04 00:00:00 EST 2021

Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation.

eLife

Russler-Germain EV,Yi J,Young S,Nutsch K,Wong HS,Ai TL,Chai JN,Durai V,Kaplan DH,Germain RN,Murphy KM,Hsieh CS

210-12 was used in In vitro experiments to suggest a model where DC-mediated effector T cell differentiation is 'dominant', necessitating that all DC subsets presenting antigen are permissive for pTreg cell induction to maintain gut tolerance.

Wed Feb 03 00:00:00 EST 2021

Reliance on Cox10 and oxidative metabolism for antigen-specific NK cell expansion.

Cell reports

Mah-Som AY,Keppel MP,Tobin JM,Kolicheski A,Saucier N,Sexl V,French AR,Wagner JA,Fehniger TA,Cooper MA

Tue Jun 01 00:00:00 EDT 2021

CXCL10⁺ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter.

Cell reports

Prizant H,Patil N,Negatu S,Bala N,McGurk A,Leddon SA,Hughson A,McRae TD,Gao YR,Livingstone AM,Groom JR,Luster AD,Fowell DJ

Tue Aug 10 00:00:00 EDT 2021

High-Dimensional T Helper Cell Profiling Reveals a Broad Diversity of Stably Committed Effector States and Uncovers Interlineage Relationships.

Immunity

Tortola L,Jacobs A,Pohlmeier L,Obermair FJ,Ampenberger F,Bodenmiller B,Kopf M

Tue Sep 15 00:00:00 EDT 2020

The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation.

Immunity

Chang D,Xing Q,Su Y,Zhao X,Xu W,Wang X,Dong C

Tue Sep 15 00:00:00 EDT 2020

Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity.

Immunity

Ni J,Wang X,Stojanovic A,Zhang Q,Wincher M,Bühler L,Arnold A,Correia MP,Winkler M,Koch PS,Sexl V,Höfer T,Cerwenka A

Tue Jun 16 00:00:00 EDT 2020

Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3⁺ Regulatory T Cells via a miR-342-Dependent Mechanism.

Immunity

Kim D,Nguyen QT,Lee J,Lee SH,Janocha A,Kim S,Le HT,Dvorina N,Weiss K,Cameron MJ,Asosingh K,Erzurum SC,Baldwin WM,Lee JS,Min B

Tue Sep 15 00:00:00 EDT 2020

Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.

Cell metabolism

Roy DG,Chen J,Mamane V,Ma EH,Muhire BM,Sheldon RD,Shorstova T,Koning R,Johnson RM,Esaulova E,Williams KS,Hayes S,Steadman M,Samborska B,Swain A,Daigneault A,Chubukov V,Roddy TP,Foulkes W,Pospisilik JA,Bourgeois-Daigneault MC,Artyomov MN,Witcher M,Krawczyk CM,Larochelle C,Jones RG

210-12 was used in In vitro experiments to investigate the role of methionine on CD4+ T helper cells.

Tue Feb 04 00:00:00 EST 2020

Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment.

Blood

Kobayashi T,Lam PY,Jiang H,Bednarska K,Gloury R,Murigneux V,Tay J,Jacquelot N,Li R,Tuong ZK,Leggatt GR,Gandhi MK,Hill MM,Belz GT,Ngo S,Kallies A,Mattarollo SR

Thu Dec 24 00:00:00 EST 2020

JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.

Blood

Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE

Thu Aug 06 00:00:00 EDT 2020

Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation.

The Journal of experimental medicine

Gao Y,Deason K,Jain A,Irizarry-Caro RA,Dozmorov I,Coughlin LA,Rauch I,Evers BM,Koh AY,Wakeland EK,Pasare C

Mon Apr 06 00:00:00 EDT 2020

Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells.

Proceedings of the National Academy of Sciences of the United States of America

Chaudhry MZ,Casalegno-Garduno R,Sitnik KM,Kasmapour B,Pulm AK,Brizic I,Eiz-Vesper B,Moosmann A,Jonjic S,Mocarski ES,Cicin-Sain L

Tue Jun 09 00:00:00 EDT 2020

Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation.

Proceedings of the National Academy of Sciences of the United States of America

Mikami N,Kawakami R,Chen KY,Sugimoto A,Ohkura N,Sakaguchi S

Tue Jun 02 00:00:00 EDT 2020

IQGAP1 restrains T-cell cosignaling mediated by OX40.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Okuyama Y,Nagashima H,Ushio-Fukai M,Croft M,Ishii N,So T

Wed Jan 01 00:00:00 EST 2020

MOSPD2 is a therapeutic target for the treatment of CNS inflammation.

Clinical and experimental immunology

Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I

210-12 was used in In vitro experiments to study the therapeutic potential of MOSPD2 in central nervous system disease.

Sat Aug 01 00:00:00 EDT 2020

Calcitriol Regulates the Differentiation of IL-9-Secreting Th9 Cells by Modulating the Transcription Factor PU.1.

Journal of immunology (Baltimore, Md. : 1950)

Vyas SP,Hansda AK,Kaplan MH,Goswami R

Sun Mar 01 00:00:00 EST 2020

Innate-like CD27⁺CD45RB^high γδ T Cells Require TCR Signaling for Homeostasis in Peripheral Lymphoid Organs.

Journal of immunology (Baltimore, Md. : 1950)

Tani-Ichi S,Wagatsuma K,Hara T,Cui G,Abe S,Miyachi H,Kitano S,Ikuta K

Fri May 15 00:00:00 EDT 2020

Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.

Journal of immunology (Baltimore, Md. : 1950)

Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D

Thu Oct 15 00:00:00 EDT 2020

CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation.

Journal of immunology (Baltimore, Md. : 1950)

Alam F,Singh A,Flores-Malavet V,Sell S,Cooper AM,Swain SL,McKinstry KK,Strutt TM

Mon Jun 15 00:00:00 EDT 2020

P2Y₆ Deficiency Enhances Dendritic Cell-Mediated Th1/Th17 Differentiation and Aggravates Experimental Autoimmune Encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Li Z,He C,Zhang J,Zhang H,Wei H,Wu S,Jiang W

Wed Jul 15 00:00:00 EDT 2020

Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells.

Journal of immunology (Baltimore, Md. : 1950)

Hewitson JP,West KA,James KR,Rani GF,Dey N,Romano A,Brown N,Teichmann SA,Kaye PM,Lagos D

Mon Jun 01 00:00:00 EDT 2020

Ethanol consumption inhibits T_FH cell responses and the development of autoimmune arthritis.

Nature communications

Azizov V,Dietel K,Steffen F,Dürholz K,Meidenbauer J,Lucas S,Frech M,Omata Y,Tajik N,Knipfer L,Kolenbrander A,Seubert S,Lapuente D,Sokolova MV,Hofmann J,Tenbusch M,Ramming A,Steffen U,Nimmerjahn F,Linker R,Wirtz S,Herrmann M,Temchura V,Sarter K,Schett G,Zaiss MM

Fri Apr 24 00:00:00 EDT 2020

Characterization of Anaphylatoxin Receptor Expression and C3a/C5a Functions in Anaphylatoxin Receptor Reporter Mice.

Current protocols in immunology

Laumonnier Y,Karsten CM,Köhl G,Köhl J

Tue Sep 01 00:00:00 EDT 2020

CD49a Regulates Cutaneous Resident Memory CD8⁺ T Cell Persistence and Response.

Cell reports

Bromley SK,Akbaba H,Mani V,Mora-Buch R,Chasse AY,Sama A,Luster AD

210-12 was used in In vitro experiments to study the requirement for CD49a in the formation, localization, persistence, and function of cutaneous CD8+ tissue-resident memory T cells.

Tue Sep 01 00:00:00 EDT 2020

Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3⁺ Regulatory T Cells.

Cell reports

Yang YH,Istomine R,Alvarez F,Al-Aubodah TA,Shi XQ,Takano T,Thornton AM,Shevach EM,Zhang J,Piccirillo CA

210-12 was used in In vitro experiments to show that high salt (HS) drives thymic Treg cells to adopt a T helper type 17 (Th17)-like phenotype and enhances generation of Th17-like induced Treg cells in a SGK1-dependent manner, all the while maintaining suppressive function.

Tue Feb 04 00:00:00 EST 2020

PU.1 regulates Ccr7 gene expression by binding to its promoter in naïve CD4⁺ T cells.

FEBS open bio

Yashiro T,Takeuchi H,Kasakura K,Nishiyama C

Mon Jun 01 00:00:00 EDT 2020

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.

Nature communications

Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A

Tue Jan 14 00:00:00 EST 2020

Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.

Scientific reports

Svendsen P,Etzerodt A,Deleuran BW,Moestrup SK

Fri Jul 24 00:00:00 EDT 2020

Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen species.

Scientific reports

Lepez A,Pirnay T,Denanglaire S,Perez-Morga D,Vermeersch M,Leo O,Andris F

Thu Dec 10 00:00:00 EST 2020

Transcription factor p73 regulates Th1 differentiation.

Nature communications

Ren M,Kazemian M,Zheng M,He J,Li P,Oh J,Liao W,Li J,Rajaseelan J,Kelsall BL,Peltz G,Leonard WJ

Thu Mar 19 00:00:00 EDT 2020

TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response.

Nature communications

Chen J,He R,Sun W,Gao R,Peng Q,Zhu L,Du Y,Ma X,Guo X,Zhang H,Tan C,Wang J,Zhang W,Weng X,Man J,Bauer H,Wang QK,Martin BN,Zhang CJ,Li X,Wang C

Mon Apr 20 00:00:00 EDT 2020

Valproic acid inhibits interferon-γ production by NK cells and increases susceptibility to Listeria monocytogenes infection.

Scientific reports

Soria-Castro R,Chávez-Blanco AD,García-Pérez BE,Wong-Baeza I,Flores-Mejía R,Flores-Borja F,Estrada-Parra S,Estrada-García I,Serafín-López J,Chacón-Salinas R

Tue Oct 20 00:00:00 EDT 2020

Unveiling the heterogeneity of NKT cells in the liver through single cell RNA sequencing.

Scientific reports

Shen H,Gu C,Liang T,Liu H,Guo F,Liu X

Tue Nov 10 00:00:00 EST 2020

Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.

Cell

Ponzetta A,Carriero R,Carnevale S,Barbagallo M,Molgora M,Perucchini C,Magrini E,Gianni F,Kunderfranco P,Polentarutti N,Pasqualini F,Di Marco S,Supino D,Peano C,Cananzi F,Colombo P,Pilotti S,Alomar SY,Bonavita E,Galdiero MR,Garlanda C,Mantovani A,Jaillon S

Thu Jul 11 00:00:00 EDT 2019

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.

Cell

Rojas OL,Pröbstel AK,Porfilio EA,Wang AA,Charabati M,Sun T,Lee DSW,Galicia G,Ramaglia V,Ward LA,Leung LYT,Najafi G,Khaleghi K,Garcillán B,Li A,Besla R,Naouar I,Cao EY,Chiaranunt P,Burrows K,Robinson HG,Allanach JR,Yam J,Luck H,Campbell DJ,Allman D,Brooks DG,Tomura M,Baumann R,Zamvil SS,Bar-Or A,Horwitz MS,Winer DA,Mortha A,Mackay F,Prat A,Osborne LC,Robbins C,Baranzini SE,Gommerman JL

Thu Jan 24 00:00:00 EST 2019

Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants.

Immunity

Bachus H,Kaur K,Papillion AM,Marquez-Lago TT,Yu Z,Ballesteros-Tato A,Matalon S,León B

Tue Jan 15 00:00:00 EST 2019

A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.

Immunity

Vacchio MS,Ciucci T,Gao Y,Watanabe M,Balmaceno-Criss M,McGinty MT,Huang A,Xiao Q,McConkey C,Zhao Y,Shetty J,Tran B,Pepper M,Vahedi G,Jenkins MK,McGavern DB,Bosselut R

Tue Sep 17 00:00:00 EDT 2019

High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation.

Immunity

Zhang D,Jin W,Wu R,Li J,Park SA,Tu E,Zanvit P,Xu J,Liu O,Cain A,Chen W

Tue Oct 15 00:00:00 EDT 2019

Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites.

Immunity

Gaylo-Moynihan A,Prizant H,Popović M,Fernandes NRJ,Anderson CS,Chiou KK,Bell H,Schrock DC,Schumacher J,Capece T,Walling BL,Topham DJ,Miller J,Smrcka AV,Kim M,Hughson A,Fowell DJ

Tue Aug 20 00:00:00 EDT 2019

The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility.

Immunity

Xu W,Zhao X,Wang X,Feng H,Gou M,Jin W,Wang X,Liu X,Dong C

Tue Nov 19 00:00:00 EST 2019

Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.

Immunity

Schmidleithner L,Thabet Y,Schönfeld E,Köhne M,Sommer D,Abdullah Z,Sadlon T,Osei-Sarpong C,Subbaramaiah K,Copperi F,Haendler K,Varga T,Schanz O,Bourry S,Bassler K,Krebs W,Peters AE,Baumgart AK,Schneeweiss M,Klee K,Schmidt SV,Nüssing S,Sander J,Ohkura N,Waha A,Sparwasser T,Wunderlich FT,Förster I,Ulas T,Weighardt H,Sakaguchi S,Pfeifer A,Blüher M,Dannenberg AJ,Ferreirós N,Muglia LJ,Wickenhauser C,Barry SC,Schultze JL,Beyer M

Tue May 21 00:00:00 EDT 2019

Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells.

Immunity

Tibbitt CA,Stark JM,Martens L,Ma J,Mold JE,Deswarte K,Oliynyk G,Feng X,Lambrecht BN,De Bleser P,Nylén S,Hammad H,Arsenian Henriksson M,Saeys Y,Coquet JM

Tue Jul 16 00:00:00 EDT 2019

MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells.

Immunity

Berrien-Elliott MM,Sun Y,Neal C,Ireland A,Trissal MC,Sullivan RP,Wagner JA,Leong JW,Wong P,Mah-Som AY,Wong TN,Schappe T,Keppel CR,Cortez VS,Stamatiades EG,Li MO,Colonna M,Link DC,French AR,Cooper MA,Wang WL,Boldin MP,Reddy P,Fehniger TA

Tue Sep 17 00:00:00 EDT 2019

Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis.

The Journal of clinical investigation

Kaushik DK,Bhattacharya A,Mirzaei R,Rawji KS,Ahn Y,Rho JM,Yong VW

Tue May 21 00:00:00 EDT 2019

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF.

The Journal of experimental medicine

Vetters J,van Helden MJ,Wahlen S,Tavernier SJ,Martens A,Fayazpour F,Vergote K,Vanheerswynghels M,Deswarte K,Van Moorleghem J,De Prijck S,Takahashi N,Vandenabeele P,Boon L,van Loo G,Vivier E,Lambrecht BN,Janssens S

Mon Sep 02 00:00:00 EDT 2019

The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors.

The Journal of experimental medicine

Železnjak J,Lisnić VJ,Popović B,Lisnić B,Babić M,Halenius A,L'Hernault A,Roviš TL,Hengel H,Erhard F,Redwood AJ,Vidal SM,Dölken L,Krmpotić A,Jonjić S

Mon Aug 05 00:00:00 EDT 2019

TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.

The Journal of experimental medicine

Sun X,Cui Y,Feng H,Liu H,Liu X

Mon Dec 02 00:00:00 EST 2019

Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.

The Journal of experimental medicine

Tanaka H,Arima Y,Kamimura D,Tanaka Y,Takahashi N,Uehata T,Maeda K,Satoh T,Murakami M,Akira S

Mon Jun 03 00:00:00 EDT 2019

Boosting Interleukin-12 Antitumor Activity and Synergism with Immunotherapy by Targeted Delivery with isoDGR-Tagged Nanogold.

Small (Weinheim an der Bergstrasse, Germany)

Gasparri AM,Sacchi A,Basso V,Cortesi F,Freschi M,Rrapaj E,Bellone M,Casorati G,Dellabona P,Mondino A,Corti A,Curnis F

Fri Nov 01 00:00:00 EDT 2019

Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against Toxoplasma gondii.

Proceedings of the National Academy of Sciences of the United States of America

DeLaney AA,Berry CT,Christian DA,Hart A,Bjanes E,Wynosky-Dolfi MA,Li X,Tummers B,Udalova IA,Chen YH,Hershberg U,Freedman BD,Hunter CA,Brodsky IE

Tue Jun 11 00:00:00 EDT 2019

Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection.

Mucosal immunology

Ren W,Liao Y,Ding X,Jiang Y,Yan J,Xia Y,Tan B,Lin Z,Duan J,Jia X,Yang G,Deng J,Zhu C,Hardwidge PR,Li J,Zhu G,Yin Y

Fri Mar 01 00:00:00 EST 2019

Proteomic Profiling of Mouse Helper T Cell Differentiation.

Proteomics

van den Ham HJ,Binai NA,Zaaraoui-Boutahar F,Heck AJR,Andeweg AC

Mon Apr 01 00:00:00 EDT 2019

Next Generation Sequencing for Long Non-coding RNAs Profile for CD4⁺ T Cells in the Mouse Model of Acute Asthma.

Frontiers in genetics

Wang Z,Ji N,Chen Z,Wu C,Sun Z,Yu W,Hu F,Huang M,Zhang M

210-12 was used in Cell Culture to explore the lncRNAs profile in the CD4+T cells from the mouse model of acute asthma.

Fri Apr 08 00:00:00 EDT 2022

EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming.

Nature communications

Istaces N,Splittgerber M,Lima Silva V,Nguyen M,Thomas S,Le A,Achouri Y,Calonne E,Defrance M,Fuks F,Goriely S,Azouz A

Wed Jul 24 00:00:00 EDT 2019

Single-cell RNA-Seq analysis identifies a noncoding interleukin 4 (IL-4) RNA that post-transcriptionally up-regulates IL-4 production in T helper cells.

The Journal of biological chemistry

Yin W,Song Y,Chang X

Fri Jan 04 00:00:00 EST 2019

Targeting T Cell Activation and Lupus Autoimmune Phenotypes by Inhibiting Glucose Transporters.

Frontiers in immunology

Li W,Qu G,Choi SC,Cornaby C,Titov A,Kanda N,Teng X,Wang H,Morel L

210-12 was used in Cell Culture to suggest that blocking glucose uptake with a small molecule inhibitor ameliorates autoimmune activation, at least partially due to its inhibition of glycolysis in CD4+ T cells.

Thu Sep 24 00:00:00 EDT 2020

IL-12 Blocks Tfh Cell Differentiation during Salmonella Infection, thereby Contributing to Germinal Center Suppression.

Cell reports

Elsner RA,Shlomchik MJ

210-12 was used in In vivo experiments to investigate the mechanisms of Salmonella enterica serovar Typhimurium (STm) that driving germinal centers suppression.

Tue Nov 26 00:00:00 EST 2019

Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells.

Cell reports

Myers DR,Norlin E,Vercoulen Y,Roose JP

210-12 was used in Cell Culture to investigate the role of Rasgrp1 in selective and robust tonic mTORC1 signals in CD4+ T cells.

Tue May 07 00:00:00 EDT 2019

Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells.

eLife

Park E,Patel S,Wang Q,Andhey P,Zaitsev K,Porter S,Hershey M,Bern M,Plougastel-Douglas B,Collins P,Colonna M,Murphy KM,Oltz E,Artyomov M,Sibley LD,Yokoyama WM

210-12 was used in In vitro experiments to explore apparently permanent transformation of NK cells into ILC1-like cells in the Toxoplasma gondii infection.

Thu Aug 08 00:00:00 EDT 2019

Pathogenic function of bystander-activated memory-like CD4⁺ T cells in autoimmune encephalomyelitis.

Nature communications

Lee HG,Lee JU,Kim DH,Lim S,Kang I,Choi JM

Tue Feb 12 00:00:00 EST 2019

c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.

Nature

Xu M,Pokrovskii M,Ding Y,Yi R,Au C,Harrison OJ,Galan C,Belkaid Y,Bonneau R,Littman DR

Thu Feb 15 00:00:00 EST 2018

Developmental Origin Governs CD8⁺ T Cell Fate Decisions during Infection.

Cell

Smith NL,Patel RK,Reynaldi A,Grenier JK,Wang J,Watson NB,Nzingha K,Yee Mon KJ,Peng SA,Grimson A,Davenport MP,Rudd BD

Thu Jun 28 00:00:00 EDT 2018

Developmental Origin Governs CD8⁺ T Cell Fate Decisions during Infection.

Cell

Smith NL,Patel RK,Reynaldi A,Grenier JK,Wang J,Watson NB,Nzingha K,Yee Mon KJ,Peng SA,Grimson A,Davenport MP,Rudd BD

Thu Jun 28 00:00:00 EDT 2018

T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.

Immunity

Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W

Tue Apr 17 00:00:00 EDT 2018

KLRG1⁺ Effector CD8⁺ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.

Immunity

Herndler-Brandstetter D,Ishigame H,Shinnakasu R,Plajer V,Stecher C,Zhao J,Lietzenmayer M,Kroehling L,Takumi A,Kometani K,Inoue T,Kluger Y,Kaech SM,Kurosaki T,Okada T,Flavell RA

Tue Apr 17 00:00:00 EDT 2018

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.

Immunity

Garris CS,Arlauckas SP,Kohler RH,Trefny MP,Garren S,Piot C,Engblom C,Pfirschke C,Siwicki M,Gungabeesoon J,Freeman GJ,Warren SE,Ong S,Browning E,Twitty CG,Pierce RH,Le MH,Algazi AP,Daud AI,Pai SI,Zippelius A,Weissleder R,Pittet MJ

Tue Dec 18 00:00:00 EST 2018

Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.

Immunity

Wang Z,Yin W,Zhu L,Li J,Yao Y,Chen F,Sun M,Zhang J,Shen N,Song Y,Chang X

Tue Jul 17 00:00:00 EDT 2018

Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4.

Immunity

Shimba A,Cui G,Tani-Ichi S,Ogawa M,Abe S,Okazaki F,Kitano S,Miyachi H,Yamada H,Hara T,Yoshikai Y,Nagasawa T,Schütz G,Ikuta K

Tue Feb 20 00:00:00 EST 2018

Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8⁺ T Cells.

Immunity

Page N,Klimek B,De Roo M,Steinbach K,Soldati H,Lemeille S,Wagner I,Kreutzfeldt M,Di Liberto G,Vincenti I,Lingner T,Salinas G,Brück W,Simons M,Murr R,Kaye J,Zehn D,Pinschewer DD,Merkler D

Tue May 15 00:00:00 EDT 2018

Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression.

Cell metabolism

Cong J,Wang X,Zheng X,Wang D,Fu B,Sun R,Tian Z,Wei H

210-12 was used in Cell Culture to identify novel mechanisms in natural killer cell dysfunction.

Tue Aug 07 00:00:00 EDT 2018

BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation.

The Journal of experimental medicine

Deason K,Troutman TD,Jain A,Challa DK,Mandraju R,Brewer T,Ward ES,Pasare C

Mon Sep 03 00:00:00 EDT 2018

The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination.

The Journal of experimental medicine

Yu F,Sharma S,Jankovic D,Gurram RK,Su P,Hu G,Li R,Rieder S,Zhao K,Sun B,Zhu J

Mon Jul 02 00:00:00 EDT 2018

USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.

The Journal of experimental medicine

Chen S,Yun F,Yao Y,Cao M,Zhang Y,Wang J,Song X,Qian Y

Mon Nov 05 00:00:00 EST 2018

Trim33 mediates the proinflammatory function of Th17 cells.

The Journal of experimental medicine

Tanaka S,Jiang Y,Martinez GJ,Tanaka K,Yan X,Kurosaki T,Kaartinen V,Feng XH,Tian Q,Wang X,Dong C

210-12 was used in In vitro experiments to study the mechanism by which transforming growth factor-β regulates reciprocal regulatory T cell and T helper 17 differentiation.

Mon Jul 02 00:00:00 EDT 2018

CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells.

Proceedings of the National Academy of Sciences of the United States of America

Stanko K,Iwert C,Appelt C,Vogt K,Schumann J,Strunk FJ,Ahrlich S,Schlickeiser S,Romagnani C,Jürchott K,Meisel C,Willimsky G,Kühl AA,Sawitzki B

Tue Mar 27 00:00:00 EDT 2018

Naive CD4⁺ T Cells Carrying a TLR2 Agonist Overcome TGF-β-Mediated Tumor Immune Evasion.

Journal of immunology (Baltimore, Md. : 1950)

Ibrahim M,Scozzi D,Toth KA,Ponti D,Kreisel D,Menna C,De Falco E,D'Andrilli A,Rendina EA,Calogero A,Krupnick AS,Gelman AE

Mon Jan 15 00:00:00 EST 2018

Select Clr-g Expression on Activated Dendritic Cells Facilitates Cognate Interaction with a Minor Subset of Splenic NK Cells Expressing the Inhibitory Nkrp1g Receptor.

Journal of immunology (Baltimore, Md. : 1950)

Friede ME,Leibelt S,Dudziak D,Steinle A

Thu Feb 01 00:00:00 EST 2018

IVIg Promote Cross-Tolerance against Inflammatory Stimuli In Vitro and In Vivo.

Journal of immunology (Baltimore, Md. : 1950)

Domínguez-Soto Á,Simón-Fuentes M,de Las Casas-Engel M,Cuevas VD,López-Bravo M,Domínguez-Andrés J,Saz-Leal P,Sancho D,Ardavín C,Ochoa-Grullón J,Sánchez-Ramón S,Vega MA,Corbí AL

Sun Jul 01 00:00:00 EDT 2018

Novel TCR-Mediated Mechanisms of Notch Activation and Signaling.

Journal of immunology (Baltimore, Md. : 1950)

Steinbuck MP,Arakcheeva K,Winandy S

Thu Feb 01 00:00:00 EST 2018

Relative Contributions of B Cells and Dendritic Cells from Lupus-Prone Mice to CD4⁺ T Cell Polarization.

Journal of immunology (Baltimore, Md. : 1950)

Choi SC,Xu Z,Li W,Yang H,Roopenian DC,Morse HC,Morel L

Tue May 01 00:00:00 EDT 2018

Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Dabitao D,Hedrich CM,Wang F,Vacharathit V,Bream JH

Thu Mar 15 00:00:00 EDT 2018

Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3⁺ Regulatory T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Mathies F,Steffens N,Kleinschmidt D,Stuhlmann F,Huber FJ,Roy U,Meyer T,Luetgehetmann M,von Petersdorff M,Seiz O,Herkel J,Schramm C,Flavell RA,Gagliani N,Krebs C,Panzer U,Abdullah Z,Strowig T,Bedke T,Huber S

Sat Dec 15 00:00:00 EST 2018

Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity.

Journal of immunology (Baltimore, Md. : 1950)

Alice AF,Kramer G,Bambina S,Baird JR,Bahjat KS,Gough MJ,Crittenden MR

Mon Jan 01 00:00:00 EST 2018

PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5.

Journal of immunology (Baltimore, Md. : 1950)

Sen S,He Z,Ghosh S,Dery KJ,Yang L,Zhang J,Sun Z

Sun Jul 15 00:00:00 EDT 2018

Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd.

Scientific reports

Abrahamsen G,Sundvold-Gjerstad V,Habtamu M,Bogen B,Spurkland A

Thu Sep 06 00:00:00 EDT 2018

A conserved enhancer regulates Il9 expression in multiple lineages.

Nature communications

Koh B,Abdul Qayum A,Srivastava R,Fu Y,Ulrich BJ,Janga SC,Kaplan MH

Thu Nov 15 00:00:00 EST 2018

Glycolysis promotes caspase-3 activation in lipid rafts in T cells.

Cell death & disease

Secinaro MA,Fortner KA,Dienz O,Logan A,Murphy MP,Anathy V,Boyson JE,Budd RC

Fri Jan 19 00:00:00 EST 2018

Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease.

Nature communications

Meng X,Grötsch B,Luo Y,Knaup KX,Wiesener MS,Chen XX,Jantsch J,Fillatreau S,Schett G,Bozec A

Wed Jan 17 00:00:00 EST 2018

Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28.

Nature communications

Jiang Y,Liu Y,Lu H,Sun SC,Jin W,Wang X,Dong C

Thu Apr 12 00:00:00 EDT 2018

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.

Nature

Molgora M,Bonavita E,Ponzetta A,Riva F,Barbagallo M,Jaillon S,Popović B,Bernardini G,Magrini E,Gianni F,Zelenay S,Jonjić S,Santoni A,Garlanda C,Mantovani A

Thu Nov 02 00:00:00 EDT 2017

Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.

Cell

Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z

210-12 was used in In vitro experiments to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.

Thu Sep 21 00:00:00 EDT 2017

Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4⁺ T Cell Dysfunction.

Immunity

Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W

Tue Dec 19 00:00:00 EST 2017

miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.

The Journal of clinical investigation

Li B,Wang X,Choi IY,Wang YC,Liu S,Pham AT,Moon H,Smith DJ,Rao DS,Boldin MP,Yang L

Mon Oct 02 00:00:00 EDT 2017

Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5.

Immunology and cell biology

Alberdi M,Iglesias M,Tejedor S,Merino R,López-Rodríguez C,Aramburu J

210-12 was used in Cell Culture to show that NFAT5 can modulate different T-cell responses depending on stress conditions and stimulatory context.

Sun Jan 01 00:00:00 EST 2017

SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions.

Journal of immunology (Baltimore, Md. : 1950)

Takahashi R,Nakatsukasa H,Shiozawa S,Yoshimura A

Sat Jul 01 00:00:00 EDT 2017

Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production.

Journal of immunology (Baltimore, Md. : 1950)

Olson MR,Ulrich BJ,Hummel SA,Khan I,Meuris B,Cherukuri Y,Dent AL,Janga SC,Kaplan MH

Thu Jun 01 00:00:00 EDT 2017

Cell penetrable-mouse forkhead box P3 suppresses type 1 T helper cell-mediated immunity in a murine model of delayed-type hypersensitivity.

Experimental and therapeutic medicine

Liu X,Wang J,Wang H,Zhou C,Yu Q,Yin L,Wu W,Xia S,Shao Q

210-12 was used in Sample Preparation (FC/FACS) to study the role and mechanism of PTD-mFOXP3, shown to alleviate experimental arthritis in mice, in type 1 T helper (Th1) cell-mediated immunity to show that PTD-mFOXP3 may attenuate delayed type hypersensitivity (DTH) reactions by suppressing the infiltration and activity of Th1 cells.

Wed Feb 01 00:00:00 EST 2017

Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.

NPJ Parkinson's disease

Sarkar S,Malovic E,Harishchandra DS,Ghaisas S,Panicker N,Charli A,Palanisamy BN,Rokad D,Jin H,Anantharam V,Kanthasamy A,Kanthasamy AG

Wed Sep 30 00:00:00 EDT 2020

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity.

Nature communications

Vaeth M,Yang J,Yamashita M,Zee I,Eckstein M,Knosp C,Kaufmann U,Karoly Jani P,Lacruz RS,Flockerzi V,Kacskovics I,Prakriya M,Feske S

Wed Mar 15 00:00:00 EDT 2017

A complex of Neuroplastin and Plasma Membrane Ca²⁺ ATPase controls T cell activation.

Scientific reports

Korthals M,Langnaese K,Smalla KH,Kähne T,Herrera-Molina R,Handschuh J,Lehmann AC,Mamula D,Naumann M,Seidenbecher C,Zuschratter W,Tedford K,Gundelfinger ED,Montag D,Fischer KD,Thomas U

Mon Aug 21 00:00:00 EDT 2017

IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.

Scientific reports

Mitchell RE,Hassan M,Burton BR,Britton G,Hill EV,Verhagen J,Wraith DC

Tue Sep 12 00:00:00 EDT 2017

Non-thermal atmospheric plasma ameliorates imiquimod-induced psoriasis-like skin inflammation in mice through inhibition of immune responses and up-regulation of PD-L1 expression.

Scientific reports

Lee YS,Lee MH,Kim HJ,Won HR,Kim CH

Tue Nov 14 00:00:00 EST 2017

Innate CD8αα⁺ lymphocytes enhance anti-CD40 antibody-mediated colitis in mice.

Immunity, inflammation and disease

Kumar AA,Delgado AG,Piazuelo MB,Van Kaer L,Olivares-Villagómez D

Thu Jun 01 00:00:00 EDT 2017

Intestinal mononuclear cells primed by systemic interleukin-12 display long-term ability to aggravate colitis in mice.

Immunology

Pedrotti LP,Sena AA,Rodriguez Galán MC,Cejas H,Correa SG

210-12 was used in Flow cytometry/Cell sorting to address whether the burst of systemic interleukin-12 (IL-12) influences intestinal inflammation elicited by luminal stimuli, we induced IL-12 release by cDNA injection in C57BL/6 mice and simultaneously started dextran sulphate sodium administration.

Wed Mar 01 00:00:00 EST 2017

The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression.

Immunity

Ichiyama K,Gonzalez-Martin A,Kim BS,Jin HY,Jin W,Xu W,Sabouri-Ghomi M,Xu S,Zheng P,Xiao C,Dong C

Tue Jun 21 00:00:00 EDT 2016

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

Immunity

Delconte RB,Shi W,Sathe P,Ushiki T,Seillet C,Minnich M,Kolesnik TB,Rankin LC,Mielke LA,Zhang JG,Busslinger M,Smyth MJ,Hutchinson DS,Nutt SL,Nicholson SE,Alexander WS,Corcoran LM,Vivier E,Belz GT,Carotta S,Huntington ND

Tue Jan 19 00:00:00 EST 2016

Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.

Immunity

Bhattacharya N,Yuan R,Prestwood TR,Penny HL,DiMaio MA,Reticker-Flynn NE,Krois CR,Kenkel JA,Pham TD,Carmi Y,Tolentino L,Choi O,Hulett R,Wang J,Winer DA,Napoli JL,Engleman EG

Tue Sep 20 00:00:00 EDT 2016

Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands.

Immunity

Cortez VS,Cervantes-Barragan L,Robinette ML,Bando JK,Wang Y,Geiger TL,Gilfillan S,Fuchs A,Vivier E,Sun JC,Cella M,Colonna M

Tue May 17 00:00:00 EDT 2016

The breast tumor microenvironment alters the phenotype and function of natural killer cells.

Cellular & molecular immunology

Krneta T,Gillgrass A,Chew M,Ashkar AA

210-12 was used in In vivo experiments to investigate the developmental stage of tumour-associated NK cells, showing that the tumour microenvironment alters the phenotype and function of NK cells.

Thu Sep 01 00:00:00 EDT 2016

Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1.

The Journal of experimental medicine

Guo H,Cranert SA,Lu Y,Zhong MC,Zhang S,Chen J,Li R,Mahl SE,Wu N,Davidson D,Waggoner SN,Veillette A

Mon Sep 19 00:00:00 EDT 2016

miR-23∼27∼24 clusters control effector T cell differentiation and function.

The Journal of experimental medicine

Cho S,Wu CJ,Yasuda T,Cruz LO,Khan AA,Lin LL,Nguyen DT,Miller M,Lee HM,Kuo ML,Broide DH,Rajewsky K,Rudensky AY,Lu LF

Mon Feb 08 00:00:00 EST 2016

A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells.

The Journal of experimental medicine

Liu WH,Kang SG,Huang Z,Wu CJ,Jin HY,Maine CJ,Liu Y,Shepherd J,Sabouri-Ghomi M,Gonzalez-Martin A,Xu S,Hoffmann A,Zheng Y,Lu LF,Xiao N,Fu G,Xiao C

Mon Aug 22 00:00:00 EDT 2016

NK cells activated by Interleukin-4 in cooperation with Interleukin-15 exhibit distinctive characteristics.

Proceedings of the National Academy of Sciences of the United States of America

Kiniwa T,Enomoto Y,Terazawa N,Omi A,Miyata N,Ishiwata K,Miyajima A

Tue Sep 06 00:00:00 EDT 2016

Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival.

Proceedings of the National Academy of Sciences of the United States of America

Rabacal W,Pabbisetty SK,Hoek KL,Cendron D,Guo Y,Maseda D,Sebzda E

Tue May 10 00:00:00 EDT 2016

Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.

Proceedings of the National Academy of Sciences of the United States of America

Liu CF,Brandt GS,Hoang QQ,Naumova N,Lazarevic V,Hwang ES,Dekker J,Glimcher LH,Ringe D,Petsko GA

Tue Oct 25 00:00:00 EDT 2016

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology.

Journal of immunology (Baltimore, Md. : 1950)

Brucklacher-Waldert V,Ferreira C,Innocentin S,Kamdar S,Withers DR,Kullberg MC,Veldhoen M

Wed Jun 15 00:00:00 EDT 2016

IL-12 Signals through the TCR To Support CD8 Innate Immune Responses.

Journal of immunology (Baltimore, Md. : 1950)

Goplen NP,Saxena V,Knudson KM,Schrum AG,Gil D,Daniels MA,Zamoyska R,Teixeiro E

Thu Sep 15 00:00:00 EDT 2016

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.

Journal of immunology (Baltimore, Md. : 1950)

Barros-Martins J,Schmolka N,Fontinha D,Pires de Miranda M,Simas JP,Brok I,Ferreira C,Veldhoen M,Silva-Santos B,Serre K

Sun May 01 00:00:00 EDT 2016

The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development.

Journal of immunology (Baltimore, Md. : 1950)

Koh B,Hufford MM,Pham D,Olson MR,Wu T,Jabeen R,Sun X,Kaplan MH

Thu Sep 15 00:00:00 EDT 2016

Differential Role of Hematopoietic and Nonhematopoietic Cell Types in the Regulation of NK Cell Tolerance and Responsiveness.

Journal of immunology (Baltimore, Md. : 1950)

Shifrin NT,Kissiov DU,Ardolino M,Joncker NT,Raulet DH

Tue Nov 15 00:00:00 EST 2016

NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950)

Iraolagoitia XL,Spallanzani RG,Torres NI,Araya RE,Ziblat A,Domaica CI,Sierra JM,Nuñez SY,Secchiari F,Gajewski TF,Zwirner NW,Fuertes MB

Mon Aug 01 00:00:00 EDT 2016

A Simple, Versatile Antibody-Based Barcoding Method for Flow Cytometry.

Journal of immunology (Baltimore, Md. : 1950)

Akkaya B,Miozzo P,Holstein AH,Shevach EM,Pierce SK,Akkaya M

Thu Sep 01 00:00:00 EDT 2016

Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells.

Journal of immunology (Baltimore, Md. : 1950)

McArdel SL,Brown DR,Sobel RA,Sharpe AH

Sat Oct 15 00:00:00 EDT 2016

Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function.

Journal of immunology (Baltimore, Md. : 1950)

Kaufmann U,Shaw PJ,Kozhaya L,Subramanian R,Gaida K,Unutmaz D,McBride HJ,Feske S

Fri Jan 15 00:00:00 EST 2016

TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease.

Journal of immunology (Baltimore, Md. : 1950)

Kourepini E,Paschalidis N,Simoes DC,Aggelakopoulou M,Grogan JL,Panoutsakopoulou V

Sun May 01 00:00:00 EDT 2016

Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Radtke D,Lacher SM,Szumilas N,Sandrock L,Ackermann J,Nitschke L,Zinser E

Fri Apr 01 00:00:00 EDT 2016

ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid.

Journal of immunology (Baltimore, Md. : 1950)

Aggelakopoulou M,Kourepini E,Paschalidis N,Simoes DC,Kalavrizioti D,Dimisianos N,Papathanasopoulos P,Mouzaki A,Panoutsakopoulou V

Sat Oct 01 00:00:00 EDT 2016

ERβ in CD4+ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Aggelakopoulou M,Kourepini E,Paschalidis N,Panoutsakopoulou V

Wed Jun 15 00:00:00 EDT 2016

Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.

Nature communications

O'Leary CE,Riling CR,Spruce LA,Ding H,Kumar S,Deng G,Liu Y,Seeholzer SH,Oliver PM

Mon Apr 18 00:00:00 EDT 2016

Bone-protective Functions of Netrin 1 Protein.

The Journal of biological chemistry

Maruyama K,Kawasaki T,Hamaguchi M,Hashimoto M,Furu M,Ito H,Fujii T,Takemura N,Karuppuchamy T,Kondo T,Kawasaki T,Fukasaka M,Misawa T,Saitoh T,Suzuki Y,Martino MM,Kumagai Y,Akira S

Fri Nov 11 00:00:00 EST 2016

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.

Nature communications

Göbel K,Pankratz S,Asaridou CM,Herrmann AM,Bittner S,Merker M,Ruck T,Glumm S,Langhauser F,Kraft P,Krug TF,Breuer J,Herold M,Gross CC,Beckmann D,Korb-Pap A,Schuhmann MK,Kuerten S,Mitroulis I,Ruppert C,Nolte MW,Panousis C,Klotz L,Kehrel B,Korn T,Langer HF,Pap T,Nieswandt B,Wiendl H,Chavakis T,Kleinschnitz C,Meuth SG

Wed May 18 00:00:00 EDT 2016

Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.

Scientific reports

Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I

Tue May 17 00:00:00 EDT 2016

RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.

Scientific reports

Drujont L,Lemoine A,Moreau A,Bienvenu G,Lancien M,Cens T,Guillot F,Bériou G,Bouchet-Delbos L,Fehling HJ,Chiffoleau E,Nicot AB,Charnet P,Martin JC,Josien R,Cuturi MC,Louvet C

Thu Mar 24 00:00:00 EDT 2016

Assessment of NK Cell Metabolism.

Methods in molecular biology (Clifton, N.J.)

Keppel MP,Cooper MA

210-12 was used in In vitro experiments to present methods for using inhibitors to alter cellular metabolism, measurement of intracellular ATP in NK cells, assessment of real-time glycolysis and oxidative phosphorylation by an extracellular flux assay from Seahorse Biosciences, and some basic protocols for stimulation of NK cells via cytokines and receptors.

Mon Dec 25 00:00:00 EST 2017

Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.

Scientific reports

Kawalkowska J,Quirke AM,Ghari F,Davis S,Subramanian V,Thompson PR,Williams RO,Fischer R,La Thangue NB,Venables PJ

Mon May 23 00:00:00 EDT 2016

Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response.

The Journal of biological chemistry

Pasi S,Kant R,Surolia A

Fri Jun 03 00:00:00 EDT 2016

TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis.

Scientific reports

Chen X,Nie Y,Xiao H,Bian Z,Scarzello AJ,Song NY,Trivett AL,Yang D,Oppenheim JJ

Wed Sep 07 00:00:00 EDT 2016

T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.

Nature communications

Krausgruber T,Schiering C,Adelmann K,Harrison OJ,Chomka A,Pearson C,Ahern PP,Shale M,Oukka M,Powrie F

Thu May 19 00:00:00 EDT 2016

Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses.

The Journal of biological chemistry

Akhter N,Takeda Y,Nara H,Araki A,Ishii N,Asao N,Asao H

Fri Nov 04 00:00:00 EDT 2016

Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.

Immunity

Guerrini MM,Okamoto K,Komatsu N,Sawa S,Danks L,Penninger JM,Nakashima T,Takayanagi H

Tue Dec 15 00:00:00 EST 2015

The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells.

Immunity

Ichiyama K,Chen T,Wang X,Yan X,Kim BS,Tanaka S,Ndiaye-Lobry D,Deng Y,Zou Y,Zheng P,Tian Q,Aifantis I,Wei L,Dong C

Tue Apr 21 00:00:00 EDT 2015

Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells.

The Journal of experimental medicine

Sekiya T,Kondo T,Shichita T,Morita R,Ichinose H,Yoshimura A

Mon Sep 21 00:00:00 EDT 2015

The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function.

The Journal of experimental medicine

Barnes MJ,Li CM,Xu Y,An J,Huang Y,Cyster JG

Mon Jun 29 00:00:00 EDT 2015

SIRT1 deacetylates RORγt and enhances Th17 cell generation.

The Journal of experimental medicine

Lim HW,Kang SG,Ryu JK,Schilling B,Fei M,Lee IS,Kehasse A,Shirakawa K,Yokoyama M,Schnölzer M,Kasler HG,Kwon HS,Gibson BW,Sato H,Akassoglou K,Xiao C,Littman DR,Ott M,Verdin E

Mon May 04 00:00:00 EDT 2015

PTEN regulates natural killer cell trafficking in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Leong JW,Schneider SE,Sullivan RP,Parikh BA,Anthony BA,Singh A,Jewell BA,Schappe T,Wagner JA,Link DC,Yokoyama WM,Fehniger TA

Tue Feb 17 00:00:00 EST 2015

T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses.

Proceedings of the National Academy of Sciences of the United States of America

Baumann C,Bonilla WV,Fröhlich A,Helmstetter C,Peine M,Hegazy AN,Pinschewer DD,Löhning M

Tue Mar 31 00:00:00 EDT 2015

T-cell receptor α enhancer is inactivated in αβ T lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America

del Blanco B,Angulo Ú,Krangel MS,Hernández-Munain C

Tue Apr 07 00:00:00 EDT 2015

The aged nonhematopoietic environment impairs natural killer cell maturation and function.

Aging cell

Shehata HM,Hoebe K,Chougnet CA

Wed Apr 01 00:00:00 EDT 2015

Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter.

European journal of immunology

Hill EV,Ng TH,Burton BR,Oakley CM,Malik K,Wraith DC

Wed Apr 01 00:00:00 EDT 2015

NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis.

European journal of immunology

Reppert S,Zinser E,Holzinger C,Sandrock L,Koch S,Finotto S

Fri May 01 00:00:00 EDT 2015

Activation-specific metabolic requirements for NK Cell IFN-γ production.

Journal of immunology (Baltimore, Md. : 1950)

Keppel MP,Saucier N,Mah AY,Vogel TP,Cooper MA

Sun Feb 15 00:00:00 EST 2015

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.

Journal of immunology (Baltimore, Md. : 1950)

Sakala IG,Kjer-Nielsen L,Eickhoff CS,Wang X,Blazevic A,Liu L,Fairlie DP,Rossjohn J,McCluskey J,Fremont DH,Hansen TH,Hoft DF

Wed Jul 15 00:00:00 EDT 2015

Silencing IFN-γ binding/signaling in astrocytes versus microglia leads to opposite effects on central nervous system autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Ding X,Yan Y,Li X,Li K,Ciric B,Yang J,Zhang Y,Wu S,Xu H,Chen W,Lovett-Racke AE,Zhang GX,Rostami A

Fri May 01 00:00:00 EDT 2015

IFN-γ production by memory helper T cells is required for CD40-independent alloantibody responses.

Journal of immunology (Baltimore, Md. : 1950)

Gorbacheva V,Fan R,Wang X,Baldwin WM,Fairchild RL,Valujskikh A

Sun Feb 01 00:00:00 EST 2015

Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK.

Journal of immunology (Baltimore, Md. : 1950)

Ebel ME,Awe O,Kaplan MH,Kansas GS

Mon Jun 15 00:00:00 EDT 2015

Genetic investigation of MHC-independent missing-self recognition by mouse NK cells using an in vivo bone marrow transplantation model.

Journal of immunology (Baltimore, Md. : 1950)

Chen P,Aguilar OA,Rahim MM,Allan DS,Fine JH,Kirkham CL,Ma J,Tanaka M,Tu MM,Wight A,Kartsogiannis V,Gillespie MT,Makrigiannis AP,Carlyle JR

Sun Mar 15 00:00:00 EDT 2015

Deficiency of CD40 Reveals an Important Role for LIGHT in Anti-Leishmania Immunity.

Journal of immunology (Baltimore, Md. : 1950)

Okwor I,Xu G,Tang H,Liang Y,Fu YX,Uzonna JE

Wed Jul 01 00:00:00 EDT 2015

Flt3 Ligand Is Essential for Survival and Protective Immune Responses during Toxoplasmosis.

Journal of immunology (Baltimore, Md. : 1950)

Dupont CD,Harms Pritchard G,Hidano S,Christian DA,Wagage S,Muallem G,Tait Wojno ED,Hunter CA

Sun Nov 01 00:00:00 EDT 2015

Composition, Development, and Function of Uterine Innate Lymphoid Cells.

Journal of immunology (Baltimore, Md. : 1950)

Doisne JM,Balmas E,Boulenouar S,Gaynor LM,Kieckbusch J,Gardner L,Hawkes DA,Barbara CF,Sharkey AM,Brady HJ,Brosens JJ,Moffett A,Colucci F

Thu Oct 15 00:00:00 EDT 2015

Dissecting CD8+ NKT Cell Responses to Listeria Infection Reveals a Component of Innate Resistance.

Journal of immunology (Baltimore, Md. : 1950)

Seregin SS,Chen GY,Laouar Y

Sat Aug 01 00:00:00 EDT 2015

IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity.

Journal of immunology (Baltimore, Md. : 1950)

Heiseke AF,Jeuk BH,Markota A,Straub T,Lehr HA,Reindl W,Krug AB

Tue Dec 15 00:00:00 EST 2015

Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.

Scientific reports

Guo A,He D,Xu HB,Geng CA,Zhao J

Tue Sep 15 00:00:00 EDT 2015

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.

Nature communications

Matsuda T,Murao N,Katano Y,Juliandi B,Kohyama J,Akira S,Kawai T,Nakashima K

Mon Mar 09 00:00:00 EDT 2015

Tristetraprolin regulation of interleukin-22 production.

Scientific reports

Härdle L,Bachmann M,Bollmann F,Pautz A,Schmid T,Eberhardt W,Kleinert H,Pfeilschifter J,Mühl H

Wed Oct 21 00:00:00 EDT 2015

Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations.

Scientific reports

Lesterhuis WJ,Rinaldi C,Jones A,Rozali EN,Dick IM,Khong A,Boon L,Robinson BW,Nowak AK,Bosco A,Lake RA

Tue Jul 21 00:00:00 EDT 2015

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.

Nature communications

Cook PC,Owen H,Deaton AM,Borger JG,Brown SL,Clouaire T,Jones GR,Jones LH,Lundie RJ,Marley AK,Morrison VL,Phythian-Adams AT,Wachter E,Webb LM,Sutherland TE,Thomas GD,Grainger JR,Selfridge J,McKenzie AN,Allen JE,Fagerholm SC,Maizels RM,Ivens AC,Bird A,MacDonald AS

Fri Apr 24 00:00:00 EDT 2015

Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.

Cell

Klose CSN,Flach M,Möhle L,Rogell L,Hoyler T,Ebert K,Fabiunke C,Pfeifer D,Sexl V,Fonseca-Pereira D,Domingues RG,Veiga-Fernandes H,Arnold SJ,Busslinger M,Dunay IR,Tanriver Y,Diefenbach A

Thu Apr 10 00:00:00 EDT 2014

Function of a Foxp3 cis-element in protecting regulatory T cell identity.

Cell

Li X,Liang Y,LeBlanc M,Benner C,Zheng Y

Thu Aug 14 00:00:00 EDT 2014

The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.

Immunity

Tang W,Wang H,Claudio E,Tassi I,Ha HL,Saret S,Siebenlist U

Thu Oct 16 00:00:00 EDT 2014

The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.

Nature immunology

Nagashima H,Okuyama Y,Asao A,Kawabe T,Yamaki S,Nakano H,Croft M,Ishii N,So T

210-12 was used in In vitro experiments to identify TRAF5 as a negative regulator of the IL-6 receptor signalling pathway that limits the induction of proinflammatory CD4(+) T cells.

Thu May 01 00:00:00 EDT 2014

Id2 represses E2A-mediated activation of IL-10 expression in T cells.

Blood

Masson F,Ghisi M,Groom JR,Kallies A,Seillet C,Johnstone RW,Nutt SL,Belz GT

Thu May 29 00:00:00 EDT 2014

Cytokine therapy reverses NK cell anergy in MHC-deficient tumors.

The Journal of clinical investigation

Ardolino M,Azimi CS,Iannello A,Trevino TN,Horan L,Zhang L,Deng W,Ring AM,Fischer S,Garcia KC,Raulet DH

Sat Nov 01 00:00:00 EDT 2014

CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection.

The Journal of experimental medicine

Cortez VS,Cervantes-Barragan L,Song C,Gilfillan S,McDonald KG,Tussiwand R,Edelson BT,Murakami Y,Murphy KM,Newberry RD,Sibley LD,Colonna M

Mon Apr 07 00:00:00 EDT 2014

Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease.

EMBO molecular medicine

Bilbao D,Luciani L,Johannesson B,Piszczek A,Rosenthal N

Sat Nov 01 00:00:00 EDT 2014

Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity.

Proceedings of the National Academy of Sciences of the United States of America

Okoye IS,Czieso S,Ktistaki E,Roderick K,Coomes SM,Pelly VS,Kannan Y,Perez-Lloret J,Zhao JL,Baltimore D,Langhorne J,Wilson MS

Tue Jul 29 00:00:00 EDT 2014

Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Kissick HT,Sanda MG,Dunn LK,Pellegrini KL,On ST,Noel JK,Arredouani MS

Tue Jul 08 00:00:00 EDT 2014

CD1d-unrestricted NKT cells are endowed with a hybrid function far superior than that of iNKT cells.

Proceedings of the National Academy of Sciences of the United States of America

Farr AR,Wu W,Choi B,Cavalcoli JD,Laouar Y

Tue Sep 02 00:00:00 EDT 2014

Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis.

Stem cells (Dayton, Ohio)

Glenn JD,Smith MD,Calabresi PA,Whartenby KA

Wed Oct 01 00:00:00 EDT 2014

IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals.

Journal of immunology (Baltimore, Md. : 1950)

Walsh MC,Pearce EL,Cejas PJ,Lee J,Wang LS,Choi Y

Wed Oct 15 00:00:00 EDT 2014

Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-γ-producing T cells.

Journal of immunology (Baltimore, Md. : 1950)

Mori T,Iwasaki Y,Seki Y,Iseki M,Katayama H,Yamamoto K,Takatsu K,Takaki S

Fri Aug 15 00:00:00 EDT 2014

CCAAT/enhancer-binding protein α negatively regulates IFN-γ expression in T cells.

Journal of immunology (Baltimore, Md. : 1950)

Tanaka S,Tanaka K,Magnusson F,Chung Y,Martinez GJ,Wang YH,Nurieva RI,Kurosaki T,Dong C

Mon Dec 15 00:00:00 EST 2014

Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against Listeria monocytogenes infection.

Journal of immunology (Baltimore, Md. : 1950)

Hashiguchi T,Oyamada A,Sakuraba K,Shimoda K,Nakayama KI,Iwamoto Y,Yoshikai Y,Yamada H

Thu May 15 00:00:00 EDT 2014

Complement component C5a permits the coexistence of pathogenic Th17 cells and type I IFN in lupus.

Journal of immunology (Baltimore, Md. : 1950)

Pawaria S,Ramani K,Maers K,Liu Y,Kane LP,Levesque MC,Biswas PS

Wed Oct 01 00:00:00 EDT 2014

The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Hou Y,Lin H,Zhu L,Liu Z,Hu F,Shi J,Yang T,Shi X,Guo H,Tan X,Zhang L,Wang Q,Li Z,Zhao Y

Tue Jul 01 00:00:00 EDT 2014

Proprotein convertase FURIN constrains Th2 differentiation and is critical for host resistance against Toxoplasma gondii.

Journal of immunology (Baltimore, Md. : 1950)

Oksanen A,Aittomäki S,Jankovic D,Ortutay Z,Pulkkinen K,Hämäläinen S,Rokka A,Corthals GL,Watford WT,Junttila I,O'Shea JJ,Pesu M

Mon Dec 01 00:00:00 EST 2014

The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.

Journal of immunology (Baltimore, Md. : 1950)

Lee PH,Puppi M,Schluns KS,Yu-Lee LY,Dong C,Lacorazza HD

Wed Jan 01 00:00:00 EST 2014

GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.

Journal of immunology (Baltimore, Md. : 1950)

Shiomi A,Usui T,Ishikawa Y,Shimizu M,Murakami K,Mimori T

Tue Jul 15 00:00:00 EDT 2014

Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly.

Journal of immunology (Baltimore, Md. : 1950)

Abdi K,Singh NJ,Spooner E,Kessler BM,Radaev S,Lantz L,Xiao TS,Matzinger P,Sun PD,Ploegh HL

Sun Jun 15 00:00:00 EDT 2014

Th17 cells demonstrate stable cytokine production in a proallergic environment.

Journal of immunology (Baltimore, Md. : 1950)

Glosson-Byers NL,Sehra S,Stritesky GL,Yu Q,Awe O,Pham D,Bruns HA,Kaplan MH

Mon Sep 15 00:00:00 EDT 2014

Integrin α4β1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection.

Journal of immunology (Baltimore, Md. : 1950)

Davila SJ,Olive AJ,Starnbach MN

Thu May 01 00:00:00 EDT 2014

CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-γ production in response to mature dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Stojanovic A,Fiegler N,Brunner-Weinzierl M,Cerwenka A

Thu May 01 00:00:00 EDT 2014

Type 2 innate lymphoid cells drive CD4+ Th2 cell responses.

Journal of immunology (Baltimore, Md. : 1950)

Mirchandani AS,Besnard AG,Yip E,Scott C,Bain CC,Cerovic V,Salmond RJ,Liew FY

Sat Mar 01 00:00:00 EST 2014

Defining the functional boundaries of the murine α1,3-fucosyltransferase Fut7 reveals a remarkably compact locus.

The Journal of biological chemistry

Ebel ME,Kansas GS

Fri Mar 07 00:00:00 EST 2014

Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy.

Nature communications

Burton BR,Britton GJ,Fang H,Verhagen J,Smithers B,Sabatos-Peyton CA,Carney LJ,Gough J,Strobel S,Wraith DC

Wed Sep 03 00:00:00 EDT 2014

STAT4 is required for IL-23 responsiveness in Th17 memory cells and NKT cells.

JAK-STAT

Glosson-Byers NL,Sehra S,Kaplan MH

210-12 was used in In vitro experiments to define populations of T cells that are STAT4-dependent in response to IL-23.

Mon Sep 28 00:00:00 EDT 2015

Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells.

Immunity

Fuchs A,Vermi W,Lee JS,Lonardi S,Gilfillan S,Newberry RD,Cella M,Colonna M

Thu Apr 18 00:00:00 EDT 2013

Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus.

Blood

Tinsley KW,Hong C,Luckey MA,Park JY,Kim GY,Yoon HW,Keller HR,Sacks AJ,Feigenbaum L,Park JH

Thu Oct 03 00:00:00 EDT 2013

Liver-resident NK cells confer adaptive immunity in skin-contact inflammation.

The Journal of clinical investigation

Peng H,Jiang X,Chen Y,Sojka DK,Wei H,Gao X,Sun R,Yokoyama WM,Tian Z

Mon Apr 01 00:00:00 EDT 2013

Dynamic visualization of RANKL and Th17-mediated osteoclast function.

The Journal of clinical investigation

Kikuta J,Wada Y,Kowada T,Wang Z,Sun-Wada GH,Nishiyama I,Mizukami S,Maiya N,Yasuda H,Kumanogoh A,Kikuchi K,Germain RN,Ishii M

Fri Feb 01 00:00:00 EST 2013

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2.

The Journal of experimental medicine

Sitrin J,Ring A,Garcia KC,Benoist C,Mathis D

Mon Jun 03 00:00:00 EDT 2013

USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex.

The Journal of experimental medicine

Liu X,Li H,Zhong B,Blonska M,Gorjestani S,Yan M,Tian Q,Zhang DE,Lin X,Dong C

Mon Jul 29 00:00:00 EDT 2013

Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy.

The Journal of experimental medicine

Bouchlaka MN,Sckisel GD,Chen M,Mirsoian A,Zamora AE,Maverakis E,Wilkins DE,Alderson KL,Hsiao HH,Weiss JM,Monjazeb AM,Hesdorffer C,Ferrucci L,Longo DL,Blazar BR,Wiltrout RH,Redelman D,Taub DD,Murphy WJ

Mon Oct 21 00:00:00 EDT 2013

Deficiency of β-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Li J,Wei B,Guo A,Liu C,Huang S,Du F,Fan W,Bao C,Pei G

Tue Apr 30 00:00:00 EDT 2013

MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.

Proceedings of the National Academy of Sciences of the United States of America

Chang J,Burkett PR,Borges CM,Kuchroo VK,Turka LA,Chang CH

Tue Feb 05 00:00:00 EST 2013

Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum.

Journal of immunology (Baltimore, Md. : 1950)

Wu SY,Yu JS,Liu FT,Miaw SC,Wu-Hsieh BA

Mon Apr 01 00:00:00 EDT 2013

Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction.

Journal of immunology (Baltimore, Md. : 1950)

Tamiya T,Ichiyama K,Kotani H,Fukaya T,Sekiya T,Shichita T,Honma K,Yui K,Matsuyama T,Nakao T,Fukuyama S,Inoue H,Nomura M,Yoshimura A

Sun Sep 01 00:00:00 EDT 2013

Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-γ production from CD4 T cells.

Journal of immunology (Baltimore, Md. : 1950)

Yamashita J,Iwamura C,Ito T,Narita M,Hara Y,Sasaki T,Masuda D,Takahashi M,Tsuchiya M,Hada K,Ishikawa M,Matsuo T,Ohno Y,Tanaka H,Maruyama H,Ogawa Y,Nakayama T

Mon Jul 15 00:00:00 EDT 2013

Role of IL-22- and TNF-α-producing Th22 cells in uveitis patients with Behcet's disease.

Journal of immunology (Baltimore, Md. : 1950)

Sugita S,Kawazoe Y,Imai A,Kawaguchi T,Horie S,Keino H,Takahashi M,Mochizuki M

Sat Jun 01 00:00:00 EDT 2013

Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength.

Journal of immunology (Baltimore, Md. : 1950)

Knudson KM,Hamilton SE,Daniels MA,Jameson SC,Teixeiro E

Sun Dec 15 00:00:00 EST 2013

Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

Journal of immunology (Baltimore, Md. : 1950)

Pham D,Yu Q,Walline CC,Muthukrishnan R,Blum JS,Kaplan MH

Mon Jul 15 00:00:00 EDT 2013

TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.

Journal of immunology (Baltimore, Md. : 1950)

Chen X,Wu X,Zhou Q,Howard OM,Netea MG,Oppenheim JJ

Fri Feb 01 00:00:00 EST 2013

Unique features of naive CD8+ T cell activation by IL-2.

Journal of immunology (Baltimore, Md. : 1950)

Cho JH,Kim HO,Kim KS,Yang DH,Surh CD,Sprent J

Sun Dec 01 00:00:00 EST 2013

Murine NK cell intrinsic cytokine-induced memory-like responses are maintained following homeostatic proliferation.

Journal of immunology (Baltimore, Md. : 1950)

Keppel MP,Yang L,Cooper MA

Wed May 01 00:00:00 EDT 2013

TLR activation excludes circulating naive CD8+ T cells from gut-associated lymphoid organs in mice.

Journal of immunology (Baltimore, Md. : 1950)

Heidegger S,Kirchner SK,Stephan N,Bohn B,Suhartha N,Hotz C,Anz D,Sandholzer N,Stecher B,Rüssmann H,Endres S,Bourquin C

Wed May 15 00:00:00 EDT 2013

MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways.

Journal of immunology (Baltimore, Md. : 1950)

Sullivan RP,Fogel LA,Leong JW,Schneider SE,Wong R,Romee R,Thai TH,Sexl V,Matkovich SJ,Dorn GW,French AR,Fehniger TA

Sun Dec 15 00:00:00 EST 2013

Developmental expression of IL-12Rβ2 on murine naive neonatal T cells counters the upregulation of IL-13Rα1 on primary Th1 cells and balances immunity in the newborn.

Journal of immunology (Baltimore, Md. : 1950)

Hoeman CM,Dhakal M,Zaghouani AA,Cascio JA,Wan X,Khairallah MT,Chen W,Zaghouani H

Sat Jun 15 00:00:00 EDT 2013

CX3CR1 regulates the maintenance of KLRG1+ NK cells into the bone marrow by promoting their entry into circulation.

Journal of immunology (Baltimore, Md. : 1950)

Ponzetta A,Sciumè G,Benigni G,Antonangeli F,Morrone S,Santoni A,Bernardini G

Sun Dec 01 00:00:00 EST 2013

CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection.

Journal of immunology (Baltimore, Md. : 1950)

Frazer LC,Sullivan JE,Zurenski MA,Mintus M,Tomasak TE,Prantner D,Nagarajan UM,Darville T

Tue Oct 15 00:00:00 EDT 2013

Tumor-derived vascular pericytes anergize Th cells.

Journal of immunology (Baltimore, Md. : 1950)

Bose A,Barik S,Banerjee S,Ghosh T,Mallick A,Bhattacharyya Majumdar S,Goswami KK,Bhuniya A,Banerjee S,Baral R,Storkus WJ,Dasgupta PS,Majumdar S

Mon Jul 15 00:00:00 EDT 2013

IL-12-based vaccination therapy reverses liver-induced systemic tolerance in a mouse model of hepatitis B virus carrier.

Journal of immunology (Baltimore, Md. : 1950)

Zeng Z,Kong X,Li F,Wei H,Sun R,Tian Z

Tue Oct 15 00:00:00 EDT 2013

CD62L is critical for maturation and accumulation of murine hepatic NK cells in response to viral infection.

Journal of immunology (Baltimore, Md. : 1950)

Peng H,Sun R,Tang L,Wei H,Tian Z

Mon Apr 15 00:00:00 EDT 2013

Inflammatory cytokine-mediated evasion of virus-induced tumors from NK cell control.

Journal of immunology (Baltimore, Md. : 1950)

Mishra R,Polic B,Welsh RM,Szomolanyi-Tsuda E

Mon Jul 15 00:00:00 EDT 2013

Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Kawashima H,Takatori H,Suzuki K,Iwata A,Yokota M,Suto A,Minamino T,Hirose K,Nakajima H

Tue Oct 01 00:00:00 EDT 2013

Nuclear receptor NR4A2 orchestrates Th17 cell-mediated autoimmune inflammation via IL-21 signalling.

PloS one

Raveney BJ,Oki S,Yamamura T

Tue Sep 10 00:00:00 EDT 2013

The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.

The Journal of biological chemistry

Pham D,Walline CC,Hollister K,Dent AL,Blum JS,Firulli AB,Kaplan MH

Fri Sep 20 00:00:00 EDT 2013

Compensatory dendritic cell development mediated by BATF-IRF interactions.

Nature

Tussiwand R,Lee WL,Murphy TL,Mashayekhi M,KC W,Albring JC,Satpathy AT,Rotondo JA,Edelson BT,Kretzer NM,Wu X,Weiss LA,Glasmacher E,Li P,Liao W,Behnke M,Lam SS,Aurthur CT,Leonard WJ,Singh H,Stallings CL,Sibley LD,Schreiber RD,Murphy KM

Thu Oct 25 00:00:00 EDT 2012

Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy.

Blood

Tietze JK,Wilkins DE,Sckisel GD,Bouchlaka MN,Alderson KL,Weiss JM,Ames E,Bruhn KW,Craft N,Wiltrout RH,Longo DL,Lanier LL,Blazar BR,Redelman D,Murphy WJ

Thu Mar 29 00:00:00 EDT 2012

Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.

The Journal of clinical investigation

Yiakouvaki A,Dimitriou M,Karakasiliotis I,Eftychi C,Theocharis S,Kontoyiannis DL

Sun Jan 01 00:00:00 EST 2012

The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.

The Journal of clinical investigation

Brüstle A,Brenner D,Knobbe CB,Lang PA,Virtanen C,Hershenfield BM,Reardon C,Lacher SM,Ruland J,Ohashi PS,Mak TW

Sat Dec 01 00:00:00 EST 2012

Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors.

The Journal of experimental medicine

Ni J,Miller M,Stojanovic A,Garbi N,Cerwenka A

Mon Dec 17 00:00:00 EST 2012

Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.

Proceedings of the National Academy of Sciences of the United States of America

Vaeth M,Schliesser U,Müller G,Reissig S,Satoh K,Tuettenberg A,Jonuleit H,Waisman A,Müller MR,Serfling E,Sawitzki BS,Berberich-Siebelt F

Tue Oct 02 00:00:00 EDT 2012

Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression.

Journal of immunology (Baltimore, Md. : 1950)

Cedeno-Laurent F,Opperman M,Barthel SR,Kuchroo VK,Dimitroff CJ

Sun Apr 01 00:00:00 EDT 2012

Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses.

Journal of immunology (Baltimore, Md. : 1950)

Eberle ME,Dalpke AH

Fri Jun 01 00:00:00 EDT 2012

Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions.

Journal of immunology (Baltimore, Md. : 1950)

Bian Z,Guo Y,Ha B,Zen K,Liu Y

Sun Jan 15 00:00:00 EST 2012

CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract.

Journal of immunology (Baltimore, Md. : 1950)

Gondek DC,Olive AJ,Stary G,Starnbach MN

Sat Sep 01 00:00:00 EDT 2012

Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms.

Journal of immunology (Baltimore, Md. : 1950)

Poovassery JS,Bishop GA

Wed Aug 15 00:00:00 EDT 2012

Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.

Journal of immunology (Baltimore, Md. : 1950)

Pham D,Vincentz JW,Firulli AB,Kaplan MH

Sun Jul 15 00:00:00 EDT 2012

NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis.

Journal of immunology (Baltimore, Md. : 1950)

Souza-Fonseca-Guimaraes F,Parlato M,Fitting C,Cavaillon JM,Adib-Conquy M

Fri Jun 15 00:00:00 EDT 2012

Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway.

Journal of immunology (Baltimore, Md. : 1950)

Zhao YG,Wang Y,Guo Z,Gu AD,Dan HC,Baldwin AS,Hao W,Wan YY

Thu Nov 01 00:00:00 EDT 2012

Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?

Journal of immunology (Baltimore, Md. : 1950)

Abdi K,Singh NJ,Matzinger P

Fri Jun 15 00:00:00 EDT 2012

MicroRNA-deficient NK cells exhibit decreased survival but enhanced function.

Journal of immunology (Baltimore, Md. : 1950)

Sullivan RP,Leong JW,Schneider SE,Keppel CR,Germino E,French AR,Fehniger TA

Sun Apr 01 00:00:00 EDT 2012

CD23+ CD21(high) CD1d(high) B cells in inflamed lymph nodes are a locally differentiated population with increased antigen capture and activation potential.

Journal of immunology (Baltimore, Md. : 1950)

Moshkani S,Kuzin II,Adewale F,Jansson J,Sanz I,Schwarz EM,Bottaro A

Fri Jun 15 00:00:00 EDT 2012

NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease.

Journal of immunology (Baltimore, Md. : 1950)

Wortham BW,Eppert BL,Motz GT,Flury JL,Orozco-Levi M,Hoebe K,Panos RJ,Maxfield M,Glasser SW,Senft AP,Raulet DH,Borchers MT

Tue May 01 00:00:00 EDT 2012

Fyn promotes Th17 differentiation by regulating the kinetics of RORγt and Foxp3 expression.

Journal of immunology (Baltimore, Md. : 1950)

Ueda A,Zhou L,Stein PL

Fri Jun 01 00:00:00 EDT 2012

TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.

PloS one

Ohnishi H,Tochio H,Kato Z,Kawamoto N,Kimura T,Kubota K,Yamamoto T,Funasaka T,Nakano H,Wong RW,Shirakawa M,Kondo N

Fri Dec 07 00:00:00 EST 2012

p38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals.

The Journal of biological chemistry

Hu P,Nebreda AR,Liu Y,Carlesso N,Kaplan M,Kapur R

Fri Sep 28 00:00:00 EDT 2012

Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.

PloS one

Caserta S,Nausch N,Sawtell A,Drummond R,Barr T,Macdonald AS,Mutapi F,Zamoyska R

Thu Aug 23 00:00:00 EDT 2012

HemaMax™, a recombinant human interleukin-12, is a potent mitigator of acute radiation injury in mice and non-human primates.

PloS one

Basile LA,Ellefson D,Gluzman-Poltorak Z,Junes-Gill K,Mar V,Mendonca S,Miller JD,Tom J,Trinh A,Gallaher TK

Mon Aug 27 00:00:00 EDT 2012

Systemic IL-12 administration alters hepatic dendritic cell stimulation capabilities.

PloS one

Chan T,Back TC,Subleski JJ,Weiss JM,Ortaldo JR,Wiltrout RH

Mon Aug 20 00:00:00 EDT 2012

Dual anti-OX40/IL-2 therapy augments tumor immunotherapy via IL-2R-mediated regulation of OX40 expression.

PloS one

Redmond WL,Triplett T,Floyd K,Weinberg AD

Tue Aug 21 00:00:00 EDT 2012

De novo DNA methylation is required to restrict T helper lineage plasticity.

The Journal of biological chemistry

Thomas RM,Gamper CJ,Ladle BH,Powell JD,Wells AD

Fri Jun 29 00:00:00 EDT 2012

CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites.

Immunity

Mashayekhi M,Sandau MM,Dunay IR,Frickel EM,Khan A,Goldszmid RS,Sher A,Ploegh HL,Murphy TL,Sibley LD,Murphy KM

Fri Aug 26 00:00:00 EDT 2011

Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia.

Blood

Janikashvili N,LaCasse CJ,Larmonier C,Trad M,Herrell A,Bustamante S,Bonnotte B,Har-Noy M,Larmonier N,Katsanis E

Thu Feb 03 00:00:00 EST 2011

CXCL12-CXCR4 chemokine signaling is essential for NK-cell development in adult mice.

Blood

Noda M,Omatsu Y,Sugiyama T,Oishi S,Fujii N,Nagasawa T

Thu Jan 13 00:00:00 EST 2011

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice.

Blood

Hao Y,O'Neill P,Naradikian MS,Scholz JL,Cancro MP

Thu Aug 04 00:00:00 EDT 2011

SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage.

Blood

Giroux M,Delisle JS,Gauthier SD,Heinonen KM,Hinsinger J,Houde B,Gaboury L,Brochu S,Wu J,Hébert MJ,Perreault C

Thu Feb 03 00:00:00 EST 2011

Development of thymic NK cells from double negative 1 thymocyte precursors.

Blood

Vargas CL,Poursine-Laurent J,Yang L,Yokoyama WM

Thu Sep 29 00:00:00 EDT 2011

CX3CR1 expression defines 2 KLRG1+ mouse NK-cell subsets with distinct functional properties and positioning in the bone marrow.

Blood

Sciumè G,De Angelis G,Benigni G,Ponzetta A,Morrone S,Santoni A,Bernardini G

Thu Apr 28 00:00:00 EDT 2011

Absence of Stat1 in donor CD4⁺ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice.

The Journal of clinical investigation

Ma H,Lu C,Ziegler J,Liu A,Sepulveda A,Okada H,Lentzsch S,Mapara MY

Fri Jul 01 00:00:00 EDT 2011

Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.

The Journal of experimental medicine

Stock A,Booth S,Cerundolo V

Mon Apr 11 00:00:00 EDT 2011

SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.

The Journal of experimental medicine

Knosp CA,Carroll HP,Elliott J,Saunders SP,Nel HJ,Amu S,Pratt JC,Spence S,Doran E,Cooke N,Jackson R,Swift J,Fitzgerald DC,Heaney LG,Fallon PG,Kissenpfennig A,Johnston JA

Mon Jul 04 00:00:00 EDT 2011

Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection.

The Journal of experimental medicine

Brigl M,Tatituri RV,Watts GF,Bhowruth V,Leadbetter EA,Barton N,Cohen NR,Hsu FF,Besra GS,Brenner MB

Mon Jun 06 00:00:00 EDT 2011

Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections.

PLoS pathogens

Coers J,Gondek DC,Olive AJ,Rohlfing A,Taylor GA,Starnbach MN

Wed Jun 01 00:00:00 EDT 2011

Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.

PLoS pathogens

Ingram JT,Yi JS,Zajac AJ

Thu Sep 01 00:00:00 EDT 2011

Cyclosporine-resistant, Rab27a-independent mobilization of intracellular preformed CD40 ligand mediates antigen-specific T cell help in vitro.

Journal of immunology (Baltimore, Md. : 1950)

Koguchi Y,Gardell JL,Thauland TJ,Parker DC

Fri Jul 15 00:00:00 EDT 2011

TCR-dependent and -independent activation underlie liver-specific regulation of NKT cells.

Journal of immunology (Baltimore, Md. : 1950)

Subleski JJ,Hall VL,Wolfe TB,Scarzello AJ,Weiss JM,Chan T,Hodge DL,Back TC,Ortaldo JR,Wiltrout RH

Sat Jan 15 00:00:00 EST 2011

Retinal self-antigen induces a predominantly Th1 effector response in Axl and Mertk double-knockout mice.

Journal of immunology (Baltimore, Md. : 1950)

Ye F,Han L,Lu Q,Dong W,Chen Z,Shao H,Kaplan HJ,Li Q,Lu Q

Sat Oct 15 00:00:00 EDT 2011

Epigenetic changes at Il12rb2 and Tbx21 in relation to plasticity behavior of Th17 cells.

Journal of immunology (Baltimore, Md. : 1950)

Bending D,Newland S,Krejcí A,Phillips JM,Bray S,Cooke A

Tue Mar 15 00:00:00 EDT 2011

MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades.

Journal of immunology (Baltimore, Md. : 1950)

Wang X,Zhang F,Chen F,Liu D,Zheng Y,Zhang Y,Dong C,Su B

Sun May 15 00:00:00 EDT 2011

Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Obar JJ,Jellison ER,Sheridan BS,Blair DA,Pham QM,Zickovich JM,Lefrançois L

Tue Nov 15 00:00:00 EST 2011

Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.

Journal of immunology (Baltimore, Md. : 1950)

LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N

Thu Dec 15 00:00:00 EST 2011

Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells.

Journal of immunology (Baltimore, Md. : 1950)

Mattapallil MJ,Silver PB,Mattapallil JJ,Horai R,Karabekian Z,McDowell JH,Chan CC,James EA,Kwok WW,Sen HN,Nussenblatt RB,David CS,Caspi RR

Mon Aug 15 00:00:00 EDT 2011

Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.

Journal of immunology (Baltimore, Md. : 1950)

Ishizaki M,Akimoto T,Muromoto R,Yokoyama M,Ohshiro Y,Sekine Y,Maeda H,Shimoda K,Oritani K,Matsuda T

Fri Jul 01 00:00:00 EDT 2011

Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis.

Journal of immunology (Baltimore, Md. : 1950)

Galitovskiy V,Qian J,Chernyavsky AI,Marchenko S,Gindi V,Edwards RA,Grando SA

Thu Sep 01 00:00:00 EDT 2011

A new look at immune privilege of the eye: dual role for the vision-related molecule retinoic acid.

Journal of immunology (Baltimore, Md. : 1950)

Zhou R,Horai R,Mattapallil MJ,Caspi RR

Sat Oct 15 00:00:00 EDT 2011

A new look at immune privilege of the eye: dual role for the vision-related molecule retinoic acid.

Journal of immunology (Baltimore, Md. : 1950)

Zhou R,Horai R,Mattapallil MJ,Caspi RR

Sat Oct 15 00:00:00 EDT 2011

Elf3 regulates allergic airway inflammation by controlling dendritic cell-driven T cell differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Kushwah R,Oliver JR,Wu J,Chang Z,Hu J

Tue Nov 01 00:00:00 EDT 2011

IL-32gamma induces the maturation of dendritic cells with Th1- and Th17-polarizing ability through enhanced IL-12 and IL-6 production.

Journal of immunology (Baltimore, Md. : 1950)

Jung MY,Son MH,Kim SH,Cho D,Kim TS

Wed Jun 15 00:00:00 EDT 2011

Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Wang L,Du C,Lv J,Wei W,Cui Y,Xie X

Thu Sep 01 00:00:00 EDT 2011

Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17.

Journal of immunology (Baltimore, Md. : 1950)

Nakagawa R,Yoshida H,Asakawa M,Tamiya T,Inoue N,Morita R,Inoue H,Nakao A,Yoshimura A

Tue Nov 01 00:00:00 EDT 2011

IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii.

Journal of immunology (Baltimore, Md. : 1950)

Silver JS,Stumhofer JS,Passos S,Ernst M,Hunter CA

Fri Jul 01 00:00:00 EDT 2011

Resident peritoneal NK cells.

Journal of immunology (Baltimore, Md. : 1950)

Gonzaga R,Matzinger P,Perez-Diez A

Thu Dec 15 00:00:00 EST 2011

Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals.

PloS one

Iguchi-Hashimoto M,Usui T,Yoshifuji H,Shimizu M,Kobayashi S,Ito Y,Murakami K,Shiomi A,Yukawa N,Kawabata D,Nojima T,Ohmura K,Fujii T,Mimori T

Mon Mar 26 00:00:00 EDT 2012

Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production.

The Journal of biological chemistry

Fujita-Sato S,Ito S,Isobe T,Ohyama T,Wakabayashi K,Morishita K,Ando O,Isono F

Fri Sep 09 00:00:00 EDT 2011

Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.

PloS one

Takeuchi H,Yokota A,Ohoka Y,Iwata M

Fri Jan 07 00:00:00 EST 2011

Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.

PloS one

Haas JD,Nistala K,Petermann F,Saran N,Chennupati V,Schmitz S,Korn T,Wedderburn LR,Förster R,Krueger A,Prinz I

Thu Sep 29 00:00:00 EDT 2011

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.

Nature communications

Sekiya T,Kashiwagi I,Inoue N,Morita R,Hori S,Waldmann H,Rudensky AY,Ichinose H,Metzger D,Chambon P,Yoshimura A

Fri Jul 22 00:00:00 EDT 2011

IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.

PloS one

Eto D,Lao C,DiToro D,Barnett B,Escobar TC,Kageyama R,Yusuf I,Crotty S

Mon Mar 14 00:00:00 EDT 2011

Inhibition of suppressive T cell factor 1 (TCF-1) isoforms in naive CD4+ T cells is mediated by IL-4/STAT6 signaling.

The Journal of biological chemistry

Maier E,Hebenstreit D,Posselt G,Hammerl P,Duschl A,Horejs-Hoeck J

Fri Jan 14 00:00:00 EST 2011

Deletion of the aryl hydrocarbon receptor enhances the inflammatory response to Leishmania major infection.

International journal of biological sciences

Elizondo G,Rodríguez-Sosa M,Estrada-Muñiz E,Gonzalez FJ,Vega L

Tue May 29 00:00:00 EDT 2012

IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors.

Nature

Okamoto K,Iwai Y,Oh-Hora M,Yamamoto M,Morio T,Aoki K,Ohya K,Jetten AM,Akira S,Muta T,Takayanagi H

Thu Apr 29 00:00:00 EDT 2010

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling.

Nature

Ghoreschi K,Laurence A,Yang XP,Tato CM,McGeachy MJ,Konkel JE,Ramos HL,Wei L,Davidson TS,Bouladoux N,Grainger JR,Chen Q,Kanno Y,Watford WT,Sun HW,Eberl G,Shevach EM,Belkaid Y,Cua DJ,Chen W,O'Shea JJ

Thu Oct 21 00:00:00 EDT 2010

TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.

Blood

Cejas PJ,Walsh MC,Pearce EL,Han D,Harms GM,Artis D,Turka LA,Choi Y

Thu Jun 10 00:00:00 EDT 2010

mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS.

Blood

Turnquist HR,Cardinal J,Macedo C,Rosborough BR,Sumpter TL,Geller DA,Metes D,Thomson AW

Thu Jun 10 00:00:00 EDT 2010

Effect of diet-induced obesity on acute pancreatitis induced by administration of interleukin-12 plus interleukin-18 in mice.

Obesity (Silver Spring, Md.)

Pini M,Sennello JA,Cabay RJ,Fantuzzi G

Mon Mar 01 00:00:00 EST 2010

FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes.

Journal of immunology (Baltimore, Md. : 1950)

Tartar DM,VanMorlan AM,Wan X,Guloglu FB,Jain R,Haymaker CL,Ellis JS,Hoeman CM,Cascio JA,Dhakal M,Oukka M,Zaghouani H

Thu Apr 01 00:00:00 EDT 2010

CCR2 plays a critical role in dendritic cell maturation: possible role of CCL2 and NF-kappa B.

Journal of immunology (Baltimore, Md. : 1950)

Jimenez F,Quinones MP,Martinez HG,Estrada CA,Clark K,Garavito E,Ibarra J,Melby PC,Ahuja SS

Sat May 15 00:00:00 EDT 2010

Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development.

Journal of immunology (Baltimore, Md. : 1950)

Takimoto T,Wakabayashi Y,Sekiya T,Inoue N,Morita R,Ichiyama K,Takahashi R,Asakawa M,Muto G,Mori T,Hasegawa E,Saika S,Hara T,Nomura M,Yoshimura A

Thu Jul 15 00:00:00 EDT 2010

CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses.

Journal of immunology (Baltimore, Md. : 1950)

Sun X,Yamada H,Shibata K,Muta H,Tani K,Podack ER,Iwakura Y,Yoshikai Y

Wed Dec 15 00:00:00 EST 2010

Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice.

Journal of immunology (Baltimore, Md. : 1950)

Johannsen A,Genolet R,Legler DF,Luther SA,Luescher IF

Wed Sep 15 00:00:00 EDT 2010

CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice.

Journal of immunology (Baltimore, Md. : 1950)

Sun X,Yamada H,Shibata K,Muta H,Tani K,Podack ER,Yoshikai Y

Sun Aug 15 00:00:00 EDT 2010

Lck mediates Th2 differentiation through effects on T-bet and GATA-3.

Journal of immunology (Baltimore, Md. : 1950)

Kemp KL,Levin SD,Bryce PJ,Stein PL

Thu Apr 15 00:00:00 EDT 2010

Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Kastner L,Dwyer D,Qin FX

Mon Nov 15 00:00:00 EST 2010

Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Tait ED,Jordan KA,Dupont CD,Harris TH,Gregg B,Wilson EH,Pepper M,Dzierszinski F,Roos DS,Hunter CA

Sun Aug 01 00:00:00 EDT 2010

Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis.

PloS one

Domingues HS,Mues M,Lassmann H,Wekerle H,Krishnamoorthy G

Mon Nov 29 00:00:00 EST 2010

Docosahexaenoic acid prevents dendritic cell maturation and in vitro and in vivo expression of the IL-12 cytokine family.

Lipids in health and disease

Kong W,Yen JH,Vassiliou E,Adhikary S,Toscano MG,Ganea D

Mon Feb 01 00:00:00 EST 2010

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.

Immunity

Delgoffe GM,Kole TP,Zheng Y,Zarek PE,Matthews KL,Xiao B,Worley PF,Kozma SC,Powell JD

Fri Jun 19 00:00:00 EDT 2009

Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.

Immunity

Gomez-Rodriguez J,Sahu N,Handon R,Davidson TS,Anderson SM,Kirby MR,August A,Schwartzberg PL

Fri Oct 16 00:00:00 EDT 2009

Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells.

The Journal of experimental medicine

Gabrysová L,Nicolson KS,Streeter HB,Verhagen J,Sabatos-Peyton CA,Morgan DJ,Wraith DC

Mon Aug 03 00:00:00 EDT 2009

Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells.

The Journal of experimental medicine

McCartney S,Vermi W,Gilfillan S,Cella M,Murphy TL,Schreiber RD,Murphy KM,Colonna M

Mon Dec 21 00:00:00 EST 2009

Cytokine-induced memory-like natural killer cells.

Proceedings of the National Academy of Sciences of the United States of America

Cooper MA,Elliott JM,Keyel PA,Yang L,Carrero JA,Yokoyama WM

Tue Feb 10 00:00:00 EST 2009

Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Verhagen J,Gabrysová L,Minaee S,Sabatos CA,Anderson G,Sharpe AH,Wraith DC

Tue Mar 03 00:00:00 EST 2009

Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity.

Proceedings of the National Academy of Sciences of the United States of America

Komatsu N,Mariotti-Ferrandiz ME,Wang Y,Malissen B,Waldmann H,Hori S

Tue Feb 10 00:00:00 EST 2009

The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.

Journal of immunology (Baltimore, Md. : 1950)

Kohu K,Ohmori H,Wong WF,Onda D,Wakoh T,Kon S,Yamashita M,Nakayama T,Kubo M,Satake M

Tue Dec 15 00:00:00 EST 2009

Endotoxin augmented antigen-induced Th1 cell trafficking amplifies airway neutrophilic inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Mikhak Z,Farsidjani A,Luster AD

Mon Jun 15 00:00:00 EDT 2009

Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways.

Journal of immunology (Baltimore, Md. : 1950)

Aleyas AG,George JA,Han YW,Rahman MM,Kim SJ,Han SB,Kim BS,Kim K,Eo SK

Sat Aug 15 00:00:00 EDT 2009

Regulation of DNA demethylation during maturation of CD4+ naive T cells by the conserved noncoding sequence 1.

Journal of immunology (Baltimore, Md. : 1950)

Aoki K,Sato N,Yamaguchi A,Kaminuma O,Hosozawa T,Miyatake S

Mon Jun 15 00:00:00 EDT 2009

Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alphaalpha+TCRalphabeta+ T cells with regulatory properties.

Journal of immunology (Baltimore, Md. : 1950)

Smith TR,Tang X,Maricic I,Garcia Z,Fanchiang S,Kumar V

Mon Jun 01 00:00:00 EDT 2009

Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells.

Journal of immunology (Baltimore, Md. : 1950)

Hundt M,Harada Y,De Giorgio L,Tanimura N,Zhang W,Altman A

Sat Aug 01 00:00:00 EDT 2009

MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.

Journal of immunology (Baltimore, Md. : 1950)

Wang X,Chang X,Facchinetti V,Zhuang Y,Su B

Sun Mar 15 00:00:00 EDT 2009

Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts.

Journal of immunology (Baltimore, Md. : 1950)

Yoshimi R,Chang TH,Wang H,Atsumi T,Morse HC,Ozato K

Mon Jun 15 00:00:00 EDT 2009

Ikaros is a regulator of Il10 expression in CD4+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Umetsu SE,Winandy S

Sun Nov 01 00:00:00 EDT 2009

Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Oyamada A,Ikebe H,Itsumi M,Saiwai H,Okada S,Shimoda K,Iwakura Y,Nakayama KI,Iwamoto Y,Yoshikai Y,Yamada H

Tue Dec 01 00:00:00 EST 2009

Cutting edge: Ikaros is a regulator of Th2 cell differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Quirion MR,Gregory GD,Umetsu SE,Winandy S,Brown MA

Thu Jan 15 00:00:00 EST 2009

4-1BB functions as a survival factor in dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Choi BK,Kim YH,Kwon PM,Lee SC,Kang SW,Kim MS,Lee MJ,Kwon BS

Wed Apr 01 00:00:00 EDT 2009

A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo.

Journal of immunology (Baltimore, Md. : 1950)

Perona-Wright G,Jenkins SJ,O'Connor RA,Zienkiewicz D,McSorley HJ,Maizels RM,Anderton SM,MacDonald AS

Sun Mar 01 00:00:00 EST 2009

T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis.

Journal of immunology (Baltimore, Md. : 1950)

Gondek DC,Roan NR,Starnbach MN

Wed Jul 15 00:00:00 EDT 2009

Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock.

Journal of immunology (Baltimore, Md. : 1950)

Jung ID,Lee MG,Chang JH,Lee JS,Jeong YI,Lee CM,Park WS,Han J,Seo SK,Lee SY,Park YM

Sun Mar 01 00:00:00 EST 2009

PU.1 regulates TCR expression by modulating GATA-3 activity.

Journal of immunology (Baltimore, Md. : 1950)

Chang HC,Han L,Jabeen R,Carotta S,Nutt SL,Kaplan MH

Thu Oct 15 00:00:00 EDT 2009

ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-gamma production by mouse activated T lymphocytes.

Immunology letters

Kadoshima-Yamaoka K,Murakawa M,Goto M,Tanaka Y,Inoue H,Murafuji H,Nagahira A,Hayashi Y,Nagahira K,Miura K,Nakatsuka T,Chamoto K,Fukuda Y,Nishimura T

Sat Feb 21 00:00:00 EST 2009

The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases.

Immunity

Meylan F,Davidson TS,Kahle E,Kinder M,Acharya K,Jankovic D,Bundoc V,Hodges M,Shevach EM,Keane-Myers A,Wang EC,Siegel RM

Fri Jul 18 00:00:00 EDT 2008

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease.

The Journal of experimental medicine

Chong MM,Rasmussen JP,Rudensky AY,Littman DR

Mon Sep 01 00:00:00 EDT 2008

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.

Proceedings of the National Academy of Sciences of the United States of America

Zhou D,Medoff BD,Chen L,Li L,Zhang XF,Praskova M,Liu M,Landry A,Blumberg RS,Boussiotis VA,Xavier R,Avruch J

Tue Dec 23 00:00:00 EST 2008

Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines.

Proceedings of the National Academy of Sciences of the United States of America

Zhu Q,Egelston C,Vivekanandhan A,Uematsu S,Akira S,Klinman DM,Belyakov IM,Berzofsky JA

Tue Oct 21 00:00:00 EDT 2008

Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases.

Journal of immunology (Baltimore, Md. : 1950)

Liu X,Lee YS,Yu CR,Egwuagu CE

Thu May 01 00:00:00 EDT 2008

IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4.

Journal of immunology (Baltimore, Md. : 1950)

Kurowska-Stolarska M,Kewin P,Murphy G,Russo RC,Stolarski B,Garcia CC,Komai-Koma M,Pitman N,Li Y,Niedbala W,McKenzie AN,Teixeira MM,Liew FY,Xu D

Wed Oct 01 00:00:00 EDT 2008

Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection.

Journal of immunology (Baltimore, Md. : 1950)

Kamimura D,Bevan MJ

Wed Oct 15 00:00:00 EDT 2008

SOCS1 regulates CCR7 expression and migration of CD4+ T cells into peripheral tissues.

Journal of immunology (Baltimore, Md. : 1950)

Yu CR,Mahdi RM,Liu X,Zhang A,Naka T,Kishimoto T,Egwuagu CE

Tue Jul 15 00:00:00 EDT 2008

Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.

Journal of immunology (Baltimore, Md. : 1950)

Sahu N,Venegas AM,Jankovic D,Mitzner W,Gomez-Rodriguez J,Cannons JL,Sommers C,Love P,Sher A,Schwartzberg PL,August A

Sat Nov 01 00:00:00 EDT 2008

Herpes virus oncolytic therapy reverses tumor immune dysfunction and facilitates tumor antigen presentation.

Cancer biology & therapy

Benencia F,Courrèges MC,Fraser NW,Coukos G

210-12 was used in Enzyme-linked immunosorbent assay to show how oncolytic HSV-1716 generates vaccination effects and that that oncolytic therapy with HSV-1716 facilitates antitumor immune responses.

Fri Aug 01 00:00:00 EDT 2008

Stat4-dependent, T-bet-independent regulation of IL-10 in NK cells.

Genes and immunity

Grant LR,Yao ZJ,Hedrich CM,Wang F,Moorthy A,Wilson K,Ranatunga D,Bream JH

Sun Jun 01 00:00:00 EDT 2008

CXCL10 blockade protects mice from cyclophosphamide-induced cystitis.

Journal of immune based therapies and vaccines

Sakthivel SK,Singh UP,Singh S,Taub DD,Novakovic KR,Lillard JW

Tue Oct 28 00:00:00 EDT 2008

Immunomodulatory effects of aqueous birch pollen extracts and phytoprostanes on primary immune responses in vivo.

The Journal of allergy and clinical immunology

Gutermuth J,Bewersdorff M,Traidl-Hoffmann C,Ring J,Mueller MJ,Behrendt H,Jakob T

Wed Aug 01 00:00:00 EDT 2007

IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B

Sat Dec 15 00:00:00 EST 2007

Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells.

Journal of immunology (Baltimore, Md. : 1950)

Shimaoka T,Seino K,Kume N,Minami M,Nishime C,Suematsu M,Kita T,Taniguchi M,Matsushima K,Yonehara S

Sat Dec 15 00:00:00 EST 2007

Mast cells are essential intermediaries in regulatory T-cell tolerance.

Nature

Lu LF,Lind EF,Gondek DC,Bennett KA,Gleeson MW,Pino-Lagos K,Scott ZA,Coyle AJ,Reed JL,Van Snick J,Strom TB,Zheng XX,Noelle RJ

Thu Aug 31 00:00:00 EDT 2006

T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.

Blood

Mathur AN,Chang HC,Zisoulis DG,Kapur R,Belladonna ML,Kansas GS,Kaplan MH

Fri Sep 01 00:00:00 EDT 2006

T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.

The Journal of experimental medicine

Usui T,Preiss JC,Kanno Y,Yao ZJ,Bream JH,O'Shea JJ,Strober W

Mon Mar 20 00:00:00 EST 2006

Notch signaling is an important regulator of type 2 immunity.

The Journal of experimental medicine

Tu L,Fang TC,Artis D,Shestova O,Pross SE,Maillard I,Pear WS

Mon Oct 17 00:00:00 EDT 2005

Thymus-dependent memory phenotype CD8 T cells in naive B6.H-2Kb-/-Db-/- animals mediate an antigen-specific response against Listeria monocytogenes.

Journal of immunology (Baltimore, Md. : 1950)

Su J,Berg RE,Murray S,Forman J

Tue Nov 15 00:00:00 EST 2005

Cell proliferation and STAT6 pathways are negatively regulated in T cells by STAT1 and suppressors of cytokine signaling.

Journal of immunology (Baltimore, Md. : 1950)

Yu CR,Mahdi RM,Ebong S,Vistica BP,Chen J,Guo Y,Gery I,Egwuagu CE

Thu Jul 15 00:00:00 EDT 2004

Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen.

The Journal of experimental medicine

Berg RE,Crossley E,Murray S,Forman J

Mon Nov 17 00:00:00 EST 2003

CCR2+ and CCR5+ CD8+ T cells increase during viral infection and migrate to sites of infection.

European journal of immunology

Nansen A,Marker O,Bartholdy C,Thomsen AR

210-12 was used in Cell Culture to correlate the expression of multiple chemokine and CC chemokine receptor (CCR) genes during the course of intracerebral (i.c.) infection with lymphocytic choriomeningitis virus (LCMV) and vesicular stomatitis virus (VSV), which are prototypic of a noncytopathic and a cytopathic virus, respectively.

Sat Jul 01 00:00:00 EDT 2000

Bioinformatics

Protein Aliases: 20C2; CLMF p35; CLMF p40; Cytotoxic lymphocyte maturation factor 35 kDa subunit; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12p70; IL-12 p75; IL-12 subunit p35; IL-12 subunit p40; IL-12A; IL-12B; IL12A/B; IL12AB; ILN; Interleukin; Interleukin-12 p70; Interleukin-12 subunit alpha; Interleukin-12 subunit beta; MGC151228; MGC151232

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Gene Aliases: Il-12a; Il-12b; IL-12p35; Il-12p40; Il12a; Il12b; Il12p40; Ll12a; p35; p40

Mouse IL-12 p70 Recombinant Protein, PeproTech®

Mouse IL-12 p70 Protein (210-12-10UG) in Functional

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210-12-10UG

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