Product References
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products.
The Journal of experimental medicine
Drurey C,Lindholm HT,Coakley G,Poveda MC,Löser S,Doolan R,Gerbe F,Jay P,Harris N,Oudhoff MJ,Maizels RM
Mon Jan 03 00:00:00 EST 2022
Transcriptional neural-like signaling contributes to an immune-suppressive tumor microenvironment.
FASEB bioAdvances
Dai H,Lou S,Zhang Y,Thanawala M,Huang KC,Ji L,Carden S,Liao T,Abbassi M,Shu CJ,Lantermann A,Sadaghiani M,Blom D,Wagner J,Huang P
Sat Jan 01 00:00:00 EST 2022
Transcriptional neural-like signaling contributes to an immune-suppressive tumor microenvironment.
FASEB bioAdvances
Dai H,Lou S,Zhang Y,Thanawala M,Huang KC,Ji L,Carden S,Liao T,Abbassi M,Shu CJ,Lantermann A,Sadaghiani M,Blom D,Wagner J,Huang P
Sat Jan 01 00:00:00 EST 2022
Metabolic reprogramming of tumor-associated macrophages by collagen turnover promotes fibrosis in pancreatic cancer.
Proceedings of the National Academy of Sciences of the United States of America
LaRue MM,Parker S,Puccini J,Cammer M,Kimmelman AC,Bar-Sagi D
210-13 was used in Cell Culture to identify a role for extracellular matrix remodeling in the functional modulation of tumor-associated macrophages via metabolic rewiring.
Tue Apr 19 00:00:00 EDT 2022
C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis.
Nature communications
Park I,Goddard ME,Cole JE,Zanin N,Lyytikäinen LP,Lehtimäki T,Andreakos E,Feldmann M,Udalova I,Drozdov I,Monaco C
Tue Jan 11 00:00:00 EST 2022
Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF.
Life science alliance
Dichtl S,Sanin DE,Koss CK,Willenborg S,Petzold A,Tanzer MC,Dahl A,Kabat AM,Lindenthal L,Zeitler L,Satzinger S,Strasser A,Mann M,Roers A,Eming SA,El Kasmi KC,Pearce EJ,Murray PJ
210-13 was used in Sample Preparation to suggest that TNF's anti-M2 effects evolved to specifically modulate components of tissue and reparative M2 macrophages and TNF is therefore a context-specific modulator of M2 macrophages rather than a pan-M2 inhibitor.
Fri Apr 01 00:00:00 EDT 2022
Follicular regulatory T cells produce neuritin to regulate B cells.
Cell
Gonzalez-Figueroa P,Roco JA,Papa I,Núñez Villacís L,Stanley M,Linterman MA,Dent A,Canete PF,Vinuesa CG
Thu Apr 01 00:00:00 EDT 2021
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.
Cell metabolism
Willenborg S,Sanin DE,Jais A,Ding X,Ulas T,Nüchel J,Popović M,MacVicar T,Langer T,Schultze JL,Gerbaulet A,Roers A,Pearce EJ,Brüning JC,Trifunovic A,Eming SA
Tue Dec 07 00:00:00 EST 2021
Interleukin-4 Receptor Inhibition Targeting Metastasis Independent of Macrophages.
Molecular cancer therapeutics
Cleary MM,Bharathy N,Abraham J,Kim JA,Rudzinski ER,Michalek JE,Keller C
210-13 was used in In vitro experiments to suggest that if humanized IL4 mouse host strains are not available (or not ideal due to the need for immunosuppressing the host innate immune response for xenograft systems), then genetically-engineered mice and mouse allograft studies may be the best indicator of therapeutic targeting efficacy.
Sat May 01 00:00:00 EDT 2021
Serum- and Glucocorticoid-Inducible Kinase 1 Promotes Alternative Macrophage Polarization and Restrains Inflammation through FoxO1 and STAT3 Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Ren J,Han X,Lohner H,Liang R,Liang S,Wang H
Thu Jul 01 00:00:00 EDT 2021
Pirfenidone modulates macrophage polarization and ameliorates radiation-induced lung fibrosis by inhibiting the TGF-β1/Smad3 pathway.
Journal of cellular and molecular medicine
Ying H,Fang M,Hang QQ,Chen Y,Qian X,Chen M
Wed Sep 01 00:00:00 EDT 2021
Histone deacetylase 9 deficiency exaggerates uterine M2 macrophage polarization.
Journal of cellular and molecular medicine
Liu Y,Du M,Lin HY
Sun Aug 01 00:00:00 EDT 2021
Lactate and IL6 define separable paths of inflammatory metabolic adaptation.
Science advances
Dichtl S,Lindenthal L,Zeitler L,Behnke K,Schlösser D,Strobl B,Scheller J,El Kasmi KC,Murray PJ
210-13 was used in Cell Culture to test the interrelationships between histone lactylation (Kla) and tissue reparative gene expression.
Tue Jun 01 00:00:00 EDT 2021
A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state.
Cell reports
Fremder M,Kim SW,Khamaysi A,Shimshilashvili L,Eini-Rider H,Park IS,Hadad U,Cheon JH,Ohana E
Tue Aug 10 00:00:00 EDT 2021
Serum free culture for the expansion and study of type 2 innate lymphoid cells.
Scientific reports
de Lucía Finkel P,Sherwood C,Saranchova I,Xia W,Munro L,Pfeifer CG,Piret JM,Jefferies WA
Thu Jun 10 00:00:00 EDT 2021
Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.
Nature communications
Wang YC,Wang X,Yu J,Ma F,Li Z,Zhou Y,Zeng S,Ma X,Li YR,Neal A,Huang J,To A,Clarke N,Memarzadeh S,Pellegrini M,Yang L
Thu Jun 10 00:00:00 EDT 2021
Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice.
Nature communications
Conde E,Bertrand R,Balbino B,Bonnefoy J,Stackowicz J,Caillot N,Colaone F,Hamdi S,Houmadi R,Loste A,Kamphuis JBJ,Huetz F,Guilleminault L,Gaudenzio N,Mougel A,Hardy D,Snouwaert JN,Koller BH,Serra V,Bruhns P,Grouard-Vogel G,Reber LL
Tue May 11 00:00:00 EDT 2021
Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.
Nature communications
Schumacher MA,Hsieh JJ,Liu CY,Appel KL,Waddell A,Almohazey D,Katada K,Bernard JK,Bucar EB,Gadeock S,Maselli KM,Washington MK,Grikscheit TC,Warburton D,Rosen MJ,Frey MR
210-13 was used in Sample Preparation to study whether Sprouty2 controls secretory cell differentiation and the response to colitis.
Fri Feb 05 00:00:00 EST 2021
Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.
Nature communications
Schumacher MA,Hsieh JJ,Liu CY,Appel KL,Waddell A,Almohazey D,Katada K,Bernard JK,Bucar EB,Gadeock S,Maselli KM,Washington MK,Grikscheit TC,Warburton D,Rosen MJ,Frey MR
210-13 was used in Sample Preparation to study whether Sprouty2 controls secretory cell differentiation and the response to colitis.
Fri Feb 05 00:00:00 EST 2021
DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.
Cell death & disease
Liu L,Wu Y,Wang B,Jiang Y,Lin L,Li X,Yang S
Mon May 17 00:00:00 EDT 2021
High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming.
Nature communications
Hu G,Su Y,Kang BH,Fan Z,Dong T,Brown DR,Cheah J,Wittrup KD,Chen J
Wed Feb 03 00:00:00 EST 2021
Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.
Frontiers in immunology
Ji WH,Li DD,Wei DP,Gu AQ,Yang Y,Peng JP
210-13 was used in Cell Culture to investigate whether Cytochrome P450 26A1 (CYP26A1) regulates the polarization of uterine macrophages in early pregnancy.
Thu Feb 10 00:00:00 EST 2022
Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.
Cell
Devalaraja S,To TKJ,Folkert IW,Natesan R,Alam MZ,Li M,Tada Y,Budagyan K,Dang MT,Zhai L,Lobel GP,Ciotti GE,Eisinger-Mathason TSK,Asangani IA,Weber K,Simon MC,Haldar M
Thu Mar 19 00:00:00 EDT 2020
Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF.
Immunity
Delacher M,Imbusch CD,Hotz-Wagenblatt A,Mallm JP,Bauer K,Simon M,Riegel D,Rendeiro AF,Bittner S,Sanderink L,Pant A,Schmidleithner L,Braband KL,Echtenachter B,Fischer A,Giunchiglia V,Hoffmann P,Edinger M,Bock C,Rehli M,Brors B,Schmidl C,Feuerer M
Tue Feb 18 00:00:00 EST 2020
Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity.
Immunity
McGinty JW,Ting HA,Billipp TE,Nadjsombati MS,Khan DM,Barrett NA,Liang HE,Matsumoto I,von Moltke J
Tue Mar 17 00:00:00 EDT 2020
FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer.
EMBO molecular medicine
Zaghdoudi S,Decaup E,Belhabib I,Samain R,Cassant-Sourdy S,Rochotte J,Brunel A,Schlaepfer D,Cros J,Neuzillet C,Strehaiano M,Alard A,Tomasini R,Rajeeve V,Perraud A,Mathonnet M,Pearce OM,Martineau Y,Pyronnet S,Bousquet C,Jean C
Fri Nov 06 00:00:00 EST 2020
IL10 deficiency promotes alveolar enlargement and lymphoid dysmorphogenesis in the aged murine lung.
Aging cell
Malinina A,Dikeman D,Westbrook R,Moats M,Gidner S,Poonyagariyagorn H,Walston J,Neptune ER
Wed Apr 01 00:00:00 EDT 2020
RANKL-Targeted Combination Therapy with Osteoprotegerin Variant Devoid of TRAIL Binding Exerts Biphasic Effects on Skeletal Remodeling and Antitumor Immunity.
Molecular cancer therapeutics
Wang H,Ashton R,Hensel JA,Lee JH,Khattar V,Wang Y,Deshane JS,Ponnazhagan S
210-13 was used in Sample Preparation (FC/FACS) to establish the combine potential of TRAIL-binding-deficient-OPGY49R therapy with RANKL, against orthotopic and metastatic breast cancers, providing a viable alternate to existing therapeutic approaches.
Tue Dec 01 00:00:00 EST 2020
Heme protects intestinal mucosal barrier in DSS-induced colitis through regulating macrophage polarization in both HO-1-dependent and HO-1-independent way.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wu Y,Wu B,Zhang Z,Lu H,Fan C,Qi Q,Gao Y,Li H,Feng C,Zuo J,Tang W
Mon Jun 01 00:00:00 EDT 2020
Surfactant Protein-A Protects against IL-13-Induced Inflammation in Asthma.
Journal of immunology (Baltimore, Md. : 1950)
Francisco D,Wang Y,Conway M,Hurbon AN,Dy ABC,Addison KJ,Chu HW,Voelker DR,Ledford JG,Kraft M
Fri May 15 00:00:00 EDT 2020
Surfactant Protein-A Protects against IL-13-Induced Inflammation in Asthma.
Journal of immunology (Baltimore, Md. : 1950)
Francisco D,Wang Y,Conway M,Hurbon AN,Dy ABC,Addison KJ,Chu HW,Voelker DR,Ledford JG,Kraft M
Fri May 15 00:00:00 EDT 2020
Single and Synergistic Effects of Type 2 Cytokines on Eosinophils and Asthma Hallmarks.
Journal of immunology (Baltimore, Md. : 1950)
Beckert H,Meyer-Martin H,Buhl R,Taube C,Reuter S
Sat Feb 01 00:00:00 EST 2020
Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages.
Cell death discovery
Nasser H,Adhikary P,Abdel-Daim A,Noyori O,Panaampon J,Kariya R,Okada S,Ma W,Baba M,Takizawa H,Yamane M,Niwa H,Suzu S
Tue Sep 26 00:00:00 EDT 2023
Mouse intestinal tuft cells express advillin but not villin.
Scientific reports
Esmaeilniakooshkghazi A,George SP,Biswas R,Khurana S
Mon Jun 01 00:00:00 EDT 2020
Multi-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogramming.
Cell death & disease
Yan K,Da TT,Bian ZH,He Y,Liu MC,Liu QZ,Long J,Li L,Gao CY,Yang SH,Zhao ZB,Lian ZX
Thu Sep 24 00:00:00 EDT 2020
Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein.
Journal of neuroinflammation
Li N,Stewart T,Sheng L,Shi M,Cilento EM,Wu Y,Hong JS,Zhang J
210-13 was used in In vitro experiments to examine the potential role of monomeric α-Syn in mediating microglia polarization to develop further insights into the connection between α-Syn, neuroinflammation, and Parkinson’s disease pathogenesis.
Thu Sep 17 00:00:00 EDT 2020
LncRNA MM2P-induced, exosome-mediated transfer of Sox9 from monocyte-derived cells modulates primary chondrocytes.
Cell death & disease
Bai J,Zhang Y,Zheng X,Huang M,Cheng W,Shan H,Gao X,Zhang M,Sheng L,Dai J,Deng Y,Zhang H,Zhou X
Wed Sep 16 00:00:00 EDT 2020
Deficiency of Calcitonin Gene-Related Peptide Affects Macrophage Polarization in Osseointegration.
Frontiers in physiology
Yuan Y,Jiang Y,Wang B,Guo Y,Gong P,Xiang L
210-13 was used in Sample Preparation (FC/FACS) to study the effect of calcitonin gene-related peptide-α (CGRP) on macrophage polarization in titanium osseointegration.
Mon Sep 28 00:00:00 EDT 2020
Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.
Immunity
Dahlgren MW,Jones SW,Cautivo KM,Dubinin A,Ortiz-Carpena JF,Farhat S,Yu KS,Lee K,Wang C,Molofsky AV,Tward AD,Krummel MF,Peng T,Molofsky AB
Tue Mar 19 00:00:00 EDT 2019
Non-hematopoietic STAT6 induces epithelial tight junction dysfunction and promotes intestinal inflammation and tumorigenesis.
Mucosal immunology
Lin Y,Li B,Yang X,Liu T,Shi T,Deng B,Zhang Y,Jia L,Jiang Z,He R
Fri Nov 01 00:00:00 EDT 2019
IL-13 promotes in vivo neonatal cardiomyocyte cell cycle activity and heart regeneration.
American journal of physiology. Heart and circulatory physiology
Wodsedalek DJ,Paddock SJ,Wan TC,Auchampach JA,Kenarsary A,Tsaih SW,Flister MJ,O'Meara CC
Tue Jan 01 00:00:00 EST 2019
Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer.
Cell reports
Di Mitri D,Mirenda M,Vasilevska J,Calcinotto A,Delaleu N,Revandkar A,Gil V,Boysen G,Losa M,Mosole S,Pasquini E,D'Antuono R,Masetti M,Zagato E,Chiorino G,Ostano P,Rinaldi A,Gnetti L,Graupera M,Martins Figueiredo Fonseca AR,Pereira Mestre R,Waugh D,Barry S,De Bono J,Alimonti A
210-13 was used in Cell Culture to identify tumor-associated macrophages as targets in prostate cancer and describe a therapeutic strategy based on CXCR2 blockade to harness anti-tumorigenic potential of macrophages against this disease.
Tue Aug 20 00:00:00 EDT 2019
Immunometabolic modulation of retinal inflammation by CD36 ligand.
Scientific reports
Mellal K,Omri S,Mulumba M,Tahiri H,Fortin C,Dorion MF,Pham H,Garcia Ramos Y,Zhang J,Pundir S,Joyal JS,Bouchard JF,Sennlaub F,Febbraio M,Hardy P,Gravel SP,Marleau S,Lubell WD,Chemtob S,Ong H
Mon Sep 09 00:00:00 EDT 2019
Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D.
Nature communications
Jiang S,Lyu C,Zhao P,Li W,Kong W,Huang C,Genin GM,Du Y
Fri Aug 02 00:00:00 EDT 2019
Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses.
Scientific reports
Minshawi F,White MRH,Muller W,Humphreys N,Jackson D,Campbell BJ,Adamson A,Papoutsopoulou S
Thu Jan 17 00:00:00 EST 2019
Phase-specific functions of macrophages determine injury-mediated corneal hem- and lymphangiogenesis.
Scientific reports
Kiesewetter A,Cursiefen C,Eming SA,Hos D
Tue Jan 22 00:00:00 EST 2019
TRIM59 loss in M2 macrophages promotes melanoma migration and invasion by upregulating MMP-9 and Madcam1.
Aging
Tian Y,Guo Y,Zhu P,Zhang D,Liu S,Tang M,Wang Y,Jin Z,Li D,Yan D,Li G,Zhu X
210-13 was used in Cell Culture to suggest TRIM59 expression attenuates the tumor-promoting effect of tumor-associated macrophages, most of which resemble the M2 phenotype.
Thu Oct 10 00:00:00 EDT 2019
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.
Nature
Montoro DT,Haber AL,Biton M,Vinarsky V,Lin B,Birket SE,Yuan F,Chen S,Leung HM,Villoria J,Rogel N,Burgin G,Tsankov AM,Waghray A,Slyper M,Waldman J,Nguyen L,Dionne D,Rozenblatt-Rosen O,Tata PR,Mou H,Shivaraju M,Bihler H,Mense M,Tearney GJ,Rowe SM,Engelhardt JF,Regev A,Rajagopal J
Wed Aug 01 00:00:00 EDT 2018
Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution.
Immunity
Proto JD,Doran AC,Gusarova G,Yurdagul A,Sozen E,Subramanian M,Islam MN,Rymond CC,Du J,Hook J,Kuriakose G,Bhattacharya J,Tabas I
Tue Oct 16 00:00:00 EDT 2018
Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.
Immunity
Nadjsombati MS,McGinty JW,Lyons-Cohen MR,Jaffe JB,DiPeso L,Schneider C,Miller CN,Pollack JL,Nagana Gowda GA,Fontana MF,Erle DJ,Anderson MS,Locksley RM,Raftery D,von Moltke J
Tue Jul 17 00:00:00 EDT 2018
Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs.
Science translational medicine
Strnadel J,Carromeu C,Bardy C,Navarro M,Platoshyn O,Glud AN,Marsala S,Kafka J,Miyanohara A,Kato T,Tadokoro T,Hefferan MP,Kamizato K,Yoshizumi T,Juhas S,Juhasova J,Ho CS,Kheradmand T,Chen P,Bohaciakova D,Hruska-Plochan M,Todd AJ,Driscoll SP,Glenn TD,Pfaff SL,Klima J,Ciacci J,Curtis E,Gage FH,Bui J,Yamada K,Muotri AR,Marsala M
Wed May 09 00:00:00 EDT 2018
Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment.
The Journal of experimental medicine
Lee SH,Charmoy M,Romano A,Paun A,Chaves MM,Cope FO,Ralph DA,Sacks DL
Tue Jan 02 00:00:00 EST 2018
Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets.
mAbs
Ching KH,Collarini EJ,Abdiche YN,Bedinger D,Pedersen D,Izquierdo S,Harriman R,Zhu L,Etches RJ,van de Lavoir MC,Harriman WD,Leighton PA
210-13 was used in In vivo experiments to investigate the accessibility of mammalian epitopes in monoclonal antibody development.
Mon Jan 01 00:00:00 EST 2018
Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Dabitao D,Hedrich CM,Wang F,Vacharathit V,Bream JH
Thu Mar 15 00:00:00 EDT 2018
IL-4 and IL-13 Guide Early Thymic Progenitors To Mature toward Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Barik S,Cattin-Roy AN,Miller MM,Ukah TK,Zaghouani H
Thu Nov 15 00:00:00 EST 2018
Shaving Is an Epiphenomenon of Type I and II Anti-CD20-Mediated Phagocytosis, whereas Antigenic Modulation Limits Type I Monoclonal Antibody Efficacy.
Journal of immunology (Baltimore, Md. : 1950)
Dahal LN,Huang CY,Stopforth RJ,Mead A,Chan K,Bowater JX,Taylor MC,Narang P,Chan HTC,Kim JH,Vaughan AT,Forconi F,Beers SA
Wed Aug 15 00:00:00 EDT 2018
Golgi Phosphoprotein 2 Is a Novel Regulator of IL-12 Production and Macrophage Polarization.
Journal of immunology (Baltimore, Md. : 1950)
Zhang W,Kim H,Lv J,Zhao N,Ma X
Thu Feb 15 00:00:00 EST 2018
Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis.
Cell discovery
Rothberg JLM,Maganti HB,Jrade H,Porter CJ,Palidwor GA,Cafariello C,Battaion HL,Khan ST,Perkins TJ,Paulson RF,Ito CY,Stanford WL
Thu Aug 17 00:00:00 EDT 2023
Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization.
Cell death & disease
Weng Q,Wang J,Wang J,Wang J,Sattar F,Zhang Z,Zheng J,Xu Z,Zhao M,Liu X,Yang L,Hao G,Fang L,Lu QR,Yang B,He Q
Wed Feb 14 00:00:00 EST 2018
IL-4 enhances survival of in vitro-differentiated mouse basophils through transcription-independent signaling downstream of PI3K.
Cell death & disease
Reinhart R,Kaufmann T
Mon Jun 18 00:00:00 EDT 2018
Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity.
Nature communications
Kubota T,Inoue M,Kubota N,Takamoto I,Mineyama T,Iwayama K,Tokuyama K,Moroi M,Ueki K,Yamauchi T,Kadowaki T
Mon Nov 19 00:00:00 EST 2018
A novel method for expansion and differentiation of mouse tracheal epithelial cells in culture.
Scientific reports
Eenjes E,Mertens TCJ,Buscop-van Kempen MJ,van Wijck Y,Taube C,Rottier RJ,Hiemstra PS
Wed May 09 00:00:00 EDT 2018
Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch.
Cell
Oetjen LK,Mack MR,Feng J,Whelan TM,Niu H,Guo CJ,Chen S,Trier AM,Xu AZ,Tripathi SV,Luo J,Gao X,Yang L,Hamilton SL,Wang PL,Brestoff JR,Council ML,Brasington R,Schaffer A,Brombacher F,Hsieh CS,Gereau RW,Miller MJ,Chen ZF,Hu H,Davidson S,Liu Q,Kim BS
Thu Sep 21 00:00:00 EDT 2017
Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.
Cancer cell
Poh AR,Love CG,Masson F,Preaudet A,Tsui C,Whitehead L,Monard S,Khakham Y,Burstroem L,Lessene G,Sieber O,Lowell C,Putoczki TL,O'Donoghue RJJ,Ernst M
Mon Apr 10 00:00:00 EDT 2017
Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths.
The Journal of experimental medicine
Pelly VS,Coomes SM,Kannan Y,Gialitakis M,Entwistle LJ,Perez-Lloret J,Czieso S,Okoye IS,Rückerl D,Allen JE,Brombacher F,Wilson MS
Mon Jun 05 00:00:00 EDT 2017
A type 2 cytokine axis for thymus emigration.
The Journal of experimental medicine
White AJ,Baik S,Parnell SM,Holland AM,Brombacher F,Jenkinson WE,Anderson G
Mon Aug 07 00:00:00 EDT 2017
The transcription factor GATA4 promotes myocardial regeneration in neonatal mice.
EMBO molecular medicine
Malek Mohammadi M,Kattih B,Grund A,Froese N,Korf-Klingebiel M,Gigina A,Schrameck U,Rudat C,Liang Q,Kispert A,Wollert KC,Bauersachs J,Heineke J
Wed Feb 01 00:00:00 EST 2017
Niacin ameliorates ulcerative colitis via prostaglandin D2-mediated D prostanoid receptor 1 activation.
EMBO molecular medicine
Li J,Kong D,Wang Q,Wu W,Tang Y,Bai T,Guo L,Wei L,Zhang Q,Yu Y,Qian Y,Zuo S,Liu G,Liu Q,Wu S,Zang Y,Zhu Q,Jia D,Wang Y,Yao W,Ji Y,Yin H,Nakamura M,Lazarus M,Breyer RM,Wang L,Yu Y
Mon May 01 00:00:00 EDT 2017
Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis.
Scientific reports
Ayaub EA,Dubey A,Imani J,Botelho F,Kolb MRJ,Richards CD,Ask K
Mon Oct 16 00:00:00 EDT 2017
M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes.
Scientific reports
Bai L,Liu X,Zheng Q,Kong M,Zhang X,Hu R,Lou J,Ren F,Chen Y,Zheng S,Liu S,Han YP,Duan Z,Pandol SJ
Tue Sep 05 00:00:00 EDT 2017
Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites.
Nature
Gerbe F,Sidot E,Smyth DJ,Ohmoto M,Matsumoto I,Dardalhon V,Cesses P,Garnier L,Pouzolles M,Brulin B,Bruschi M,Harcus Y,Zimmermann VS,Taylor N,Maizels RM,Jay P
210-13 was used in In vivo experiments to study the mechanisms underlying the initiation of type 2 host responses to helminths such as Nippostrongylus brasiliensis to reveal a novel function of intestinal epithelial tuft cells and demonstrate a cellular relay required for initiating mucosal type 2 immunity to helminth infection.
Thu Jan 14 00:00:00 EST 2016
Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis.
Journal of immunology (Baltimore, Md. : 1950)
Haribhai D,Ziegelbauer J,Jia S,Upchurch K,Yan K,Schmitt EG,Salzman NH,Simpson P,Hessner MJ,Chatila TA,Williams CB
Fri Apr 15 00:00:00 EDT 2016
Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis.
Journal of immunology (Baltimore, Md. : 1950)
Haribhai D,Ziegelbauer J,Jia S,Upchurch K,Yan K,Schmitt EG,Salzman NH,Simpson P,Hessner MJ,Chatila TA,Williams CB
Fri Apr 15 00:00:00 EDT 2016
Huaier extract suppresses breast cancer via regulating tumor-associated macrophages.
Scientific reports
Li Y,Qi W,Song X,Lv S,Zhang H,Yang Q
Mon Feb 01 00:00:00 EST 2016
Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung.
Frontiers in immunology
Zimmer J,Weitnauer M,Boutin S,Küblbeck G,Thiele S,Walker P,Lasitschka F,Lunding L,Orinska Z,Vock C,Arnold B,Wegmann M,Dalpke A
210-13 was used in In vivo experiments to study the importance of nuclear translocation of SOCS1 which contains a nuclear localization sequence (NLS) to show that nuclear SOCS1 is a regulator of local immunity in the lung and unravel a so far unrecognized function for SOCS1 in the cell nucleus.
Wed Nov 20 00:00:00 EST 2019
Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Cimen Bozkus C,Elzey BD,Crist SA,Ellies LG,Ratliff TL
Tue Dec 01 00:00:00 EST 2015
IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells.
Investigative ophthalmology & visual science
Tukler Henriksson J,Coursey TG,Corry DB,De Paiva CS,Pflugfelder SC
210-13 was used in Tissue/organ culture to demonstrate that conjunctival goblet cells are IL-13 responsive cells that produce factors known to maintain epithelial barrier, stimulate mucin production, and modulate immune response in nonocular mucosa when treated with IL-13.
Wed Jul 01 00:00:00 EDT 2015
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.
The Journal of clinical investigation
Li J,Razumilava N,Gores GJ,Walters S,Mizuochi T,Mourya R,Bessho K,Wang YH,Glaser SS,Shivakumar P,Bezerra JA
Tue Jul 01 00:00:00 EDT 2014
Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease.
Cell death and differentiation
Tang Y,Li T,Li J,Yang J,Liu H,Zhang XJ,Le W
Sat Mar 01 00:00:00 EST 2014
Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis.
Journal of immunology (Baltimore, Md. : 1950)
Le TT,Karmouty-Quintana H,Melicoff E,Le TT,Weng T,Chen NY,Pedroza M,Zhou Y,Davies J,Philip K,Molina J,Luo F,George AT,Garcia-Morales LJ,Bunge RR,Bruckner BA,Loebe M,Seethamraju H,Agarwal SK,Blackburn MR
Wed Oct 01 00:00:00 EDT 2014
IL-13 orchestrates resolution of chronic intestinal inflammation via phosphorylation of glycogen synthase kinase-3β.
Journal of immunology (Baltimore, Md. : 1950)
Fichtner-Feigl S,Kesselring R,Martin M,Obermeier F,Ruemmele P,Kitani A,Brunner SM,Haimerl M,Geissler EK,Strober W,Schlitt HJ
Tue Apr 15 00:00:00 EDT 2014
Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge.
Cell death & disease
Través PG,Pardo V,Pimentel-Santillana M,González-Rodríguez Á,Mojena M,Rico D,Montenegro Y,Calés C,Martín-Sanz P,Valverde AM,Boscá L
Thu Mar 13 00:00:00 EDT 2014
Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization.
Immunity
Spence S,Fitzsimons A,Boyd CR,Kessler J,Fitzgerald D,Elliott J,Gabhann JN,Smith S,Sica A,Hams E,Saunders SP,Jefferies CA,Fallon PG,McAuley DF,Kissenpfennig A,Johnston JA
Thu Jan 24 00:00:00 EST 2013
Differential effects of γc cytokines on postselection differentiation of CD8 thymocytes.
Blood
Rafei M,Rouette A,Brochu S,Vanegas JR,Perreault C
Thu Jan 03 00:00:00 EST 2013
Direct control of hepatic glucose production by interleukin-13 in mice.
The Journal of clinical investigation
Stanya KJ,Jacobi D,Liu S,Bhargava P,Dai L,Gangl MR,Inouye K,Barlow JL,Ji Y,Mizgerd JP,Qi L,Shi H,McKenzie AN,Lee CH
Tue Jan 01 00:00:00 EST 2013
Adam8 limits the development of allergic airway inflammation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Knolle MD,Nakajima T,Hergrueter A,Gupta K,Polverino F,Craig VJ,Fyfe SE,Zahid M,Permaul P,Cernadas M,Montano G,Tesfaigzi Y,Sholl L,Kobzik L,Israel E,Owen CA
Sat Jun 15 00:00:00 EDT 2013
Alendronate attenuates eosinophilic airway inflammation associated with suppression of Th2 cytokines, Th17 cytokines, and eotaxin-2.
Journal of immunology (Baltimore, Md. : 1950)
Sasaki O,Imamura M,Yamazumi Y,Harada H,Matsumoto T,Okunishi K,Nakagome K,Tanaka R,Akiyama T,Yamamoto K,Dohi M
Sun Sep 15 00:00:00 EDT 2013
Thymic stromal lymphopoietin amplifies the differentiation of alternatively activated macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Han H,Headley MB,Xu W,Comeau MR,Zhou B,Ziegler SF
Fri Feb 01 00:00:00 EST 2013
IL-33 markedly activates murine eosinophils by an NF-κB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop.
Journal of immunology (Baltimore, Md. : 1950)
Bouffi C,Rochman M,Zust CB,Stucke EM,Kartashov A,Fulkerson PC,Barski A,Rothenberg ME
Tue Oct 15 00:00:00 EDT 2013
PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis.
Journal of immunology (Baltimore, Md. : 1950)
Chang HH,Miaw SC,Tseng W,Sun YW,Liu CC,Tsao HW,Ho IC
Sun Sep 01 00:00:00 EDT 2013
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ohta S,Imamura M,Xing W,Boyce JA,Balestrieri B
Sat Jun 15 00:00:00 EDT 2013
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.
The Journal of clinical investigation
Sugimoto K,Kudo M,Sundaram A,Ren X,Huang K,Bernstein X,Wang Y,Raymond WW,Erle DJ,Abrink M,Caughey GH,Huang X,Sheppard D
Wed Feb 01 00:00:00 EST 2012
Periostin promotes chronic allergic inflammation in response to Th2 cytokines.
The Journal of clinical investigation
Masuoka M,Shiraishi H,Ohta S,Suzuki S,Arima K,Aoki S,Toda S,Inagaki N,Kurihara Y,Hayashida S,Takeuchi S,Koike K,Ono J,Noshiro H,Furue M,Conway SJ,Narisawa Y,Izuhara K
Sun Jul 01 00:00:00 EDT 2012
Role of the tumor suppressor ARF in macrophage polarization: Enhancement of the M2 phenotype in ARF-deficient mice.
Oncoimmunology
Herranz S,Través PG,Luque A,Hortelano S
Thu Nov 01 00:00:00 EDT 2012
Multiwalled carbon nanotubes interact with macrophages and influence tumor progression and metastasis.
Theranostics
Yang M,Meng J,Cheng X,Lei J,Guo H,Zhang W,Kong H,Xu H
Tue Oct 02 00:00:00 EDT 2012
Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.
Nature
Anthony RM,Kobayashi T,Wermeling F,Ravetch JV
Sun Jun 19 00:00:00 EDT 2011
Alternative activation of macrophages by IL-4 enhances the proteolytic capacity of their phagosomes through synergistic mechanisms.
Blood
Balce DR,Li B,Allan ER,Rybicka JM,Krohn RM,Yates RM
Thu Oct 13 00:00:00 EDT 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
Mon Apr 11 00:00:00 EDT 2011
Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component.
Journal of immunology (Baltimore, Md. : 1950)
Zhang W,Xu W,Xiong S
Mon Aug 15 00:00:00 EDT 2011
Interleukin-19: a constituent of the regulome that controls antigen presenting cells in the lungs and airway responses to microbial products.
PloS one
Hoffman C,Park SH,Daley E,Emson C,Louten J,Sisco M,de Waal Malefyt R,Grunig G
Mon Mar 26 00:00:00 EDT 2012
TGF-β-mediated sustained ERK1/2 activity promotes the inhibition of intracellular growth of Mycobacterium avium in epithelioid cells surrogates.
PloS one
L'Abbate C,Cipriano I,Pérez-Hurtado EC,Leão SC,Carneiro CR,Machado J
Wed Nov 02 00:00:00 EDT 2011
Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation.
Blood
Milner JD,Orekov T,Ward JM,Cheng L,Torres-Velez F,Junttila I,Sun G,Buller M,Morris SC,Finkelman FD,Paul WE
Thu Oct 07 00:00:00 EDT 2010
Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma.
Proceedings of the National Academy of Sciences of the United States of America
Nemeth K,Keane-Myers A,Brown JM,Metcalfe DD,Gorham JD,Bundoc VG,Hodges MG,Jelinek I,Madala S,Karpati S,Mezey E
Tue Mar 23 00:00:00 EDT 2010
Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Nagarkar DR,Bowman ER,Schneider D,Wang Q,Shim J,Zhao Y,Linn MJ,McHenry CL,Gosangi B,Bentley JK,Tsai WC,Sajjan US,Lukacs NW,Hershenson MB
Sun Aug 15 00:00:00 EDT 2010
"Default" generation of neonatal regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wang G,Miyahara Y,Guo Z,Khattar M,Stepkowski SM,Chen W
Thu Jul 01 00:00:00 EDT 2010
Double-stranded RNA exacerbates pulmonary allergic reaction through TLR3: implication of airway epithelium and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Torres D,Dieudonné A,Ryffel B,Vilain E,Si-Tahar M,Pichavant M,Lassalle P,Trottein F,Gosset P
Thu Jul 01 00:00:00 EDT 2010
Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation.
Journal of immunology (Baltimore, Md. : 1950)
Rodríguez-Prados JC,Través PG,Cuenca J,Rico D,Aragonés J,Martín-Sanz P,Cascante M,Boscá L
Thu Jul 01 00:00:00 EDT 2010
12/15-lipoxygenase is an interleukin-13 and interferon-γ counterregulated-mediator of allergic airway inflammation.
Mediators of inflammation
Lindley AR,Crapster-Pregont M,Liu Y,Kuperman DA
Wed Feb 02 00:00:00 EST 2011
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.
Cancer cell
DeNardo DG,Barreto JB,Andreu P,Vasquez L,Tawfik D,Kolhatkar N,Coussens LM
Tue Aug 04 00:00:00 EDT 2009
Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma.
Nature immunology
Goswami S,Angkasekwinai P,Shan M,Greenlee KJ,Barranco WT,Polikepahad S,Seryshev A,Song LZ,Redding D,Singh B,Sur S,Woodruff P,Dong C,Corry DB,Kheradmand F
Fri May 01 00:00:00 EDT 2009
Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.
The Journal of experimental medicine
Tachdjian R,Mathias C,Al Khatib S,Bryce PJ,Kim HS,Blaeser F,O'Connor BD,Rzymkiewicz D,Chen A,Holtzman MJ,Hershey GK,Garn H,Harb H,Renz H,Oettgen HC,Chatila TA
Mon Sep 28 00:00:00 EDT 2009
CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes.
Proceedings of the National Academy of Sciences of the United States of America
Niedermeier M,Reich B,Rodriguez Gomez M,Denzel A,Schmidbauer K,Göbel N,Talke Y,Schweda F,Mack M
Tue Oct 20 00:00:00 EDT 2009
Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow.
Journal of lipid research
Marathe C,Bradley MN,Hong C,Chao L,Wilpitz D,Salazar J,Tontonoz P
Sun Feb 01 00:00:00 EST 2009
CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Medoff BD,Seung E,Hong S,Thomas SY,Sandall BP,Duffield JS,Kuperman DA,Erle DJ,Luster AD
Thu Jan 01 00:00:00 EST 2009
Non-classical natural killer T cells modulate plasmid DNA vaccine antigen expression and vaccine-elicited immune responses by MCP-1 secretion after interaction with a beta2-microglobulin-independent CD1d.
The Journal of biological chemistry
Geiben-Lynn R,Greenland JR,Frimpong-Boateng K,Letvin NL
Fri Dec 04 00:00:00 EST 2009
Transplacental passage of interleukins 4 and 13?
PloS one
Lim RH,Kobzik L
Mon Apr 27 00:00:00 EDT 2009
Regulation of alternative macrophage activation by galectin-3.
Journal of immunology (Baltimore, Md. : 1950)
MacKinnon AC,Farnworth SL,Hodkinson PS,Henderson NC,Atkinson KM,Leffler H,Nilsson UJ,Haslett C,Forbes SJ,Sethi T
Fri Feb 15 00:00:00 EST 2008
Murine plasmacytoid dendritic cells produce IFN-gamma upon IL-4 stimulation.
Journal of immunology (Baltimore, Md. : 1950)
Suto A,Nakajima H,Tokumasa N,Takatori H,Kagami S,Suzuki K,Iwamoto I
Tue Nov 01 00:00:00 EST 2005
Homeostatic T cell proliferation in a T cell-dendritic cell coculture system.
Proceedings of the National Academy of Sciences of the United States of America
Ge Q,Palliser D,Eisen HN,Chen J
Tue Mar 05 00:00:00 EST 2002
