Product References
Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection.
Nature immunology
Di Pietro A,Polmear J,Cooper L,Damelang T,Hussain T,Hailes L,O'Donnell K,Udupa V,Mi T,Preston S,Shtewe A,Hershberg U,Turner SJ,La Gruta NL,Chung AW,Tarlinton DM,Scharer CD,Good-Jacobson KL
Sat Jan 01 00:00:00 EST 2022
Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer.
Cancer immunology research
Gil Del Alcazar CR,Trinh A,Alečković M,Rojas Jimenez E,Harper NW,Oliphant MUJ,Xie S,Krop ED,Lulseged B,Murphy KC,Keenan TE,Van Allen EM,Tolaney SM,Freeman GJ,Dillon DA,Muthuswamy SK,Polyak K
210-21 was used in Tissue/organ culture to address how there are no good murine models of estrogen receptor-positive (ER+) breast cancer and demonstrate that Nitroso-N-methylurea-induced mammary tumors in outbred Sprague-Dawley rats recapitulate the heterogeneity for mutational profiles, ER expression, and immune evasive mechanisms observed in human breast cancer.
Fri Jun 03 00:00:00 EDT 2022
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.
Nature
Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA
210-21 was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.
Thu Apr 01 00:00:00 EDT 2021
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.
Nature
Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA
210-21 was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.
Thu Apr 01 00:00:00 EDT 2021
Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2.
Journal of immunology (Baltimore, Md. : 1950)
Finney J,Kelsoe G
Wed Sep 01 00:00:00 EDT 2021
GSK3 Restrains Germinal Center B Cells to Form Plasma Cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee J,Park H,Lim J,Jin HS,Park Y,Jung YJ,Ko HJ,Yoon SI,Lee GS,Kim PH,Choi SS,Xiao C,Kang SG
Mon Feb 01 00:00:00 EST 2021
Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β.
Journal of immunology (Baltimore, Md. : 1950)
Jang YS,Song HE,Seo GY,Jo HJ,Park S,Park HW,Kim TG,Kang SG,Yoon SI,Ko HJ,Lee GS,Park SR,Kim PH
Mon Nov 15 00:00:00 EST 2021
Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity.
Cell reports
Szodoray P,Andersen TK,Heinzelbecker J,Imbery JF,Huszthy PC,Stanford SM,Bogen B,Landsverk OB,Bottini N,Tveita A,Munthe LA,Nakken B
Tue Aug 10 00:00:00 EDT 2021
Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription.
Cell reports
Sun L,Zhao X,Liu X,Zhong B,Tang H,Jin W,Clevers H,Wang H,Wang X,Dong C
Tue Jun 01 00:00:00 EDT 2021
Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy.
Nature communications
Li Y,Cong Y,Jia M,He Q,Zhong H,Zhao Y,Li H,Yan M,You J,Liu J,Chen L,Hang H,Wang S
Thu Feb 11 00:00:00 EST 2021
Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D.
The Journal of clinical investigation
Zheng J,Meyerholz D,Wong LR,Gelb M,Murakami M,Perlman S
Tue Jun 01 00:00:00 EDT 2021
Circadian Clock Disruption Suppresses PDL1+ Intraepithelial B Cells in Experimental Colitis and Colitis-Associated Colorectal Cancer.
Cellular and molecular gastroenterology and hepatology
Liu JL,Wang CY,Cheng TY,Rixiati Y,Ji C,Deng M,Yao S,Yuan LH,Zhao YY,Shen T,Li JM
210-21 was used in Cell Culture to uncover the importance of the circadian clock regulating PDL1+ Breg+ cells of IELs in IBD and IBD-associated CRC.
Mon Jan 24 00:00:00 EST 2022
Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses.
Immunity
Wong R,Belk JA,Govero J,Uhrlaub JL,Reinartz D,Zhao H,Errico JM,D'Souza L,Ripperger TJ,Nikolich-Zugich J,Shlomchik MJ,Satpathy AT,Fremont DH,Diamond MS,Bhattacharya D
Tue Nov 17 00:00:00 EST 2020
E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
The Journal of clinical investigation
Wang Z,Zhao M,Yin J,Liu L,Hu L,Huang Y,Liu A,Ouyang J,Min X,Rao S,Zhou W,Wu H,Yoshimura A,Lu Q
Wed Jul 01 00:00:00 EDT 2020
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Journal of immunology (Baltimore, Md. : 1950)
Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D
Thu Oct 15 00:00:00 EDT 2020
Arhgap25 Deficiency Leads to Decreased Numbers of Peripheral Blood B Cells and Defective Germinal Center Reactions.
ImmunoHorizons
Lindner SE,Egelston CA,Huard SM,Lee PP,Wang LD
210-21 was used in Cell Culture to investigate the effects of Arhgap25 deficiency in mice on peripheral blood B cell numbers.
Wed May 20 00:00:00 EDT 2020
Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.
Immunity
Schmidleithner L,Thabet Y,Schönfeld E,Köhne M,Sommer D,Abdullah Z,Sadlon T,Osei-Sarpong C,Subbaramaiah K,Copperi F,Haendler K,Varga T,Schanz O,Bourry S,Bassler K,Krebs W,Peters AE,Baumgart AK,Schneeweiss M,Klee K,Schmidt SV,Nüssing S,Sander J,Ohkura N,Waha A,Sparwasser T,Wunderlich FT,Förster I,Ulas T,Weighardt H,Sakaguchi S,Pfeifer A,Blüher M,Dannenberg AJ,Ferreirós N,Muglia LJ,Wickenhauser C,Barry SC,Schultze JL,Beyer M
Tue May 21 00:00:00 EDT 2019
GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-κB-Dependent Mechanism.
Cancer cell
Mondragón L,Mhaidly R,De Donatis GM,Tosolini M,Dao P,Martin AR,Pons C,Chiche J,Jacquin M,Imbert V,Proïcs E,Boyer L,Doye A,Luciano F,Neels JG,Coutant F,Fabien N,Sormani L,Rubio-Patiño C,Bossowski JP,Muller F,Marchetti S,Villa E,Peyron JF,Gaulard P,Lemonnier F,Asnafi V,Genestier L,Benhida R,Fournié JJ,Passeron T,Ricci JE,Verhoeyen E
Mon Sep 16 00:00:00 EDT 2019
TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.
The Journal of experimental medicine
Sun X,Cui Y,Feng H,Liu H,Liu X
Mon Dec 02 00:00:00 EST 2019
TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.
The FEBS journal
Schoeler K,Aufschnaiter A,Messner S,Derudder E,Herzog S,Villunger A,Rajewsky K,Labi V
Sun Sep 01 00:00:00 EDT 2019
Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21.
Cell reports
Olson WJ,Jakic B,Labi V,Schoeler K,Kind M,Klepsch V,Baier G,Hermann-Kleiter N
210-21 was used in In vitro experiments to report that loss of the nuclear orphan receptor NR2F6 causes enhanced survival and accumulation of Tfh cells, GC B cells, and plasma cells following T cell-dependent immunization.
Tue Sep 10 00:00:00 EDT 2019
PRMT5 is essential for B cell development and germinal center dynamics.
Nature communications
Litzler LC,Zahn A,Meli AP,Hébert S,Patenaude AM,Methot SP,Sprumont A,Bois T,Kitamura D,Costantino S,King IL,Kleinman CL,Richard S,Di Noia JM
Thu Jan 03 00:00:00 EST 2019
Baicalin ameliorates lupus autoimmunity by inhibiting differentiation of Tfh cells and inducing expansion of Tfr cells.
Cell death & disease
Yang J,Yang X,Yang J,Li M
Wed Feb 13 00:00:00 EST 2019
RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis.
Cancer cell
Cortes JR,Ambesi-Impiombato A,Couronné L,Quinn SA,Kim CS,da Silva Almeida AC,West Z,Belver L,Martin MS,Scourzic L,Bhagat G,Bernard OA,Ferrando AA,Palomero T
Mon Feb 12 00:00:00 EST 2018
A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses.
The Journal of experimental medicine
Le Gallou S,Zhou Z,Thai LH,Fritzen R,de Los Aires AV,Mégret J,Yu P,Kitamura D,Bille E,Tros F,Nassif X,Charbit A,Weller S,Weill JC,Reynaud CA
Mon Aug 06 00:00:00 EDT 2018
Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells.
The Journal of experimental medicine
Zhang Y,Tech L,George LA,Acs A,Durrett RE,Hess H,Walker LSK,Tarlinton DM,Fletcher AL,Hauser AE,Toellner KM
Mon Apr 02 00:00:00 EDT 2018
Differential Influence on Regulatory B Cells by TH2 Cytokines Affects Protection in Allergic Airway Disease.
Journal of immunology (Baltimore, Md. : 1950)
Taitano SH,van der Vlugt LEPM,Shea MM,Yang J,Lukacs NW,Lundy SK
Mon Oct 01 00:00:00 EDT 2018
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
Thu Sep 21 00:00:00 EDT 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
Thu Sep 21 00:00:00 EDT 2017
miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.
The Journal of clinical investigation
Li B,Wang X,Choi IY,Wang YC,Liu S,Pham AT,Moon H,Smith DJ,Rao DS,Boldin MP,Yang L
Mon Oct 02 00:00:00 EDT 2017
Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4+ Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Read KA,Powell MD,Baker CE,Sreekumar BK,Ringel-Scaia VM,Bachus H,Martin RE,Cooley ID,Allen IC,Ballesteros-Tato A,Oestreich KJ
Sun Oct 01 00:00:00 EDT 2017
Absence of Grail promotes CD8+ T cell anti-tumour activity.
Nature communications
Haymaker C,Yang Y,Wang J,Zou Q,Sahoo A,Alekseev A,Singh D,Ritthipichai K,Hailemichael Y,Hoang ON,Qin H,Schluns KS,Wang T,Overwijk WW,Sun SC,Bernatchez C,Kwak LW,Neelapu SS,Nurieva R
Thu Aug 10 00:00:00 EDT 2017
Up-regulation of Interleukin-21 Contributes to Liver Pathology of Schistosomiasis by Driving GC Immune Responses and Activating HSCs in Mice.
Scientific reports
Wang Y,Lin C,Cao Y,Duan Z,Guan Z,Xu J,Zhu XQ,Xia C
Thu Nov 30 00:00:00 EST 2017
The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses.
Immunity
Chou C,Verbaro DJ,Tonc E,Holmgren M,Cella M,Colonna M,Bhattacharya D,Egawa T
Tue Sep 20 00:00:00 EDT 2016
Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume.
The Journal of clinical investigation
Lee HK,Keum S,Sheng H,Warner DS,Lo DC,Marchuk DA
Mon Aug 01 00:00:00 EDT 2016
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.
The Journal of experimental medicine
Wan X,Thomas JW,Unanue ER
Mon May 30 00:00:00 EDT 2016
STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Olson MR,Verdan FF,Hufford MM,Dent AL,Kaplan MH
Fri Apr 15 00:00:00 EDT 2016
Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.
Journal of immunology (Baltimore, Md. : 1950)
Barros-Martins J,Schmolka N,Fontinha D,Pires de Miranda M,Simas JP,Brok I,Ferreira C,Veldhoen M,Silva-Santos B,Serre K
Sun May 01 00:00:00 EDT 2016
TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development.
Journal of immunology (Baltimore, Md. : 1950)
Nagashima H,Okuyama Y,Hayashi T,Ishii N,So T
Sun May 15 00:00:00 EDT 2016
Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Jones LL,Alli R,Li B,Geiger TL
Fri Apr 01 00:00:00 EDT 2016
Artemisinin analogue SM934 attenuate collagen-induced arthritis by suppressing T follicular helper cells and T helper 17 cells.
Scientific reports
Lin ZM,Yang XQ,Zhu FH,He SJ,Tang W,Zuo JP
Tue Nov 29 00:00:00 EST 2016
Artemisinin analogue SM934 attenuate collagen-induced arthritis by suppressing T follicular helper cells and T helper 17 cells.
Scientific reports
Lin ZM,Yang XQ,Zhu FH,He SJ,Tang W,Zuo JP
Tue Nov 29 00:00:00 EST 2016
NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis.
European journal of immunology
Reppert S,Zinser E,Holzinger C,Sandrock L,Koch S,Finotto S
Fri May 01 00:00:00 EDT 2015
JNK regulatory molecule G5PR induces IgG autoantibody-producing plasmablasts from peritoneal B1a cells.
Journal of immunology (Baltimore, Md. : 1950)
Kitabatake M,Soma M,Zhang T,Kuwahara K,Fukushima Y,Nojima T,Kitamura D,Sakaguchi N
Sun Feb 15 00:00:00 EST 2015
Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK.
Journal of immunology (Baltimore, Md. : 1950)
Ebel ME,Awe O,Kaplan MH,Kansas GS
Mon Jun 15 00:00:00 EDT 2015
Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Xu M,Liu M,Du X,Li S,Li H,Li X,Li Y,Wang Y,Qin Z,Fu YX,Wang S
Fri May 15 00:00:00 EDT 2015
IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection.
Nature communications
Adoro S,Cubillos-Ruiz JR,Chen X,Deruaz M,Vrbanac VD,Song M,Park S,Murooka TT,Dudek TE,Luster AD,Tager AM,Streeck H,Bowman B,Walker BD,Kwon DS,Lazarevic V,Glimcher LH
Thu Jun 25 00:00:00 EDT 2015
IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age.
Nature communications
Tsukamoto H,Senju S,Matsumura K,Swain SL,Nishimura Y
Tue Apr 07 00:00:00 EDT 2015
The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.
Immunity
Tang W,Wang H,Claudio E,Tassi I,Ha HL,Saret S,Siebenlist U
Thu Oct 16 00:00:00 EDT 2014
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
Nature immunology
Nagashima H,Okuyama Y,Asao A,Kawabe T,Yamaki S,Nakano H,Croft M,Ishii N,So T
210-21 was used in In vitro experiments to identify TRAF5 as a negative regulator of the IL-6 receptor signalling pathway that limits the induction of proinflammatory CD4(+) T cells.
Thu May 01 00:00:00 EDT 2014
Id2 represses E2A-mediated activation of IL-10 expression in T cells.
Blood
Masson F,Ghisi M,Groom JR,Kallies A,Seillet C,Johnstone RW,Nutt SL,Belz GT
Thu May 29 00:00:00 EDT 2014
Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-β-induced Foxp3 expression.
Journal of immunology (Baltimore, Md. : 1950)
Ikeda S,Saijo S,Murayama MA,Shimizu K,Akitsu A,Iwakura Y
Sat Feb 15 00:00:00 EST 2014
Inflammation and lymphopenia trigger autoimmunity by suppression of IL-2-controlled regulatory T cell and increase of IL-21-mediated effector T cell expansion.
Journal of immunology (Baltimore, Md. : 1950)
Chevalier N,Thorburn AN,Macia L,Tan J,Juglair L,Yagita H,Yu D,Hansbro PM,Mackay CR
Sat Nov 15 00:00:00 EST 2014
IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells.
Journal of immunology (Baltimore, Md. : 1950)
Attridge K,Kenefeck R,Wardzinski L,Qureshi OS,Wang CJ,Manzotti C,Okkenhaug K,Walker LS
Sat Mar 01 00:00:00 EST 2014
Differential effects of γc cytokines on postselection differentiation of CD8 thymocytes.
Blood
Rafei M,Rouette A,Brochu S,Vanegas JR,Perreault C
Thu Jan 03 00:00:00 EST 2013
Unique features of naive CD8+ T cell activation by IL-2.
Journal of immunology (Baltimore, Md. : 1950)
Cho JH,Kim HO,Kim KS,Yang DH,Surh CD,Sprent J
Sun Dec 01 00:00:00 EST 2013
IL-4 upregulates Igα and Igβ protein, resulting in augmented IgM maturation and B cell receptor-triggered B cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Guo B,Rothstein TL
Mon Jul 15 00:00:00 EDT 2013
Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Edwards JP,Fujii H,Zhou AX,Creemers J,Unutmaz D,Shevach EM
Sat Jun 01 00:00:00 EDT 2013
Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection.
Journal of immunology (Baltimore, Md. : 1950)
Hamada H,Bassity E,Flies A,Strutt TM,Garcia-Hernandez Mde L,McKinstry KK,Zou T,Swain SL,Dutton RW
Tue Jan 01 00:00:00 EST 2013
IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis.
Blood
Attridge K,Wang CJ,Wardzinski L,Kenefeck R,Chamberlain JL,Manzotti C,Kopf M,Walker LS
Thu May 17 00:00:00 EDT 2012
IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis.
Blood
Attridge K,Wang CJ,Wardzinski L,Kenefeck R,Chamberlain JL,Manzotti C,Kopf M,Walker LS
Thu May 17 00:00:00 EDT 2012
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1.
The Journal of experimental medicine
Karnowski A,Chevrier S,Belz GT,Mount A,Emslie D,D'Costa K,Tarlinton DM,Kallies A,Corcoran LM
Mon Oct 22 00:00:00 EDT 2012
Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response.
Proceedings of the National Academy of Sciences of the United States of America
Perona-Wright G,Kohlmeier JE,Bassity E,Freitas TC,Mohrs K,Cookenham T,Situ H,Pearce EJ,Woodland DL,Mohrs M
Tue Nov 06 00:00:00 EST 2012
Fyn promotes Th17 differentiation by regulating the kinetics of RORγt and Foxp3 expression.
Journal of immunology (Baltimore, Md. : 1950)
Ueda A,Zhou L,Stein PL
Fri Jun 01 00:00:00 EDT 2012
Dual anti-OX40/IL-2 therapy augments tumor immunotherapy via IL-2R-mediated regulation of OX40 expression.
PloS one
Redmond WL,Triplett T,Floyd K,Weinberg AD
Tue Aug 21 00:00:00 EDT 2012
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells.
Immunity
Lu KT,Kanno Y,Cannons JL,Handon R,Bible P,Elkahloun AG,Anderson SM,Wei L,Sun H,O'Shea JJ,Schwartzberg PL
Fri Oct 28 00:00:00 EDT 2011
STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis.
Blood
Kaplan MH,Glosson NL,Stritesky GL,Yeh N,Kinzfogl J,Rohrabaugh SL,Goswami R,Pham D,Levy DE,Brutkiewicz RR,Blum JS,Cooper S,Hangoc G,Broxmeyer HE
Thu Jun 09 00:00:00 EDT 2011
Tolerogenic function of Blimp-1 in dendritic cells.
The Journal of experimental medicine
Kim SJ,Zou YR,Goldstein J,Reizis B,Diamond B
Mon Oct 24 00:00:00 EDT 2011
Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.
PLoS pathogens
Ingram JT,Yi JS,Zajac AJ
Thu Sep 01 00:00:00 EDT 2011
Cyclosporine-resistant, Rab27a-independent mobilization of intracellular preformed CD40 ligand mediates antigen-specific T cell help in vitro.
Journal of immunology (Baltimore, Md. : 1950)
Koguchi Y,Gardell JL,Thauland TJ,Parker DC
Fri Jul 15 00:00:00 EDT 2011
Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria.
Journal of immunology (Baltimore, Md. : 1950)
Doisne JM,Soulard V,Bécourt C,Amniai L,Henrot P,Havenar-Daughton C,Blanchet C,Zitvogel L,Ryffel B,Cavaillon JM,Marie JC,Couillin I,Benlagha K
Sat Jan 15 00:00:00 EST 2011
IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.
Journal of immunology (Baltimore, Md. : 1950)
Terawaki S,Chikuma S,Shibayama S,Hayashi T,Yoshida T,Okazaki T,Honjo T
Tue Mar 01 00:00:00 EST 2011
Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.
PloS one
Haas JD,Nistala K,Petermann F,Saran N,Chennupati V,Schmitz S,Korn T,Wedderburn LR,Förster R,Krueger A,Prinz I
Thu Sep 29 00:00:00 EDT 2011
In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo.
Nature communications
Nojima T,Haniuda K,Moutai T,Matsudaira M,Mizokawa S,Shiratori I,Azuma T,Kitamura D
Tue Sep 06 00:00:00 EDT 2011
Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine.
Journal of immunology (Baltimore, Md. : 1950)
Wang C,Kang SG,HogenEsch H,Love PE,Kim CH
Sat May 15 00:00:00 EDT 2010
Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kastner L,Dwyer D,Qin FX
Mon Nov 15 00:00:00 EST 2010
"Default" generation of neonatal regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wang G,Miyahara Y,Guo Z,Khattar M,Stepkowski SM,Chen W
Thu Jul 01 00:00:00 EDT 2010
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.
Immunity
Gomez-Rodriguez J,Sahu N,Handon R,Davidson TS,Anderson SM,Kirby MR,August A,Schwartzberg PL
Fri Oct 16 00:00:00 EDT 2009
Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities.
Blood
Eddahri F,Denanglaire S,Bureau F,Spolski R,Leonard WJ,Leo O,Andris F
Thu Mar 12 00:00:00 EDT 2009
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
The Journal of experimental medicine
Dienz O,Eaton SM,Bond JP,Neveu W,Moquin D,Noubade R,Briso EM,Charland C,Leonard WJ,Ciliberto G,Teuscher C,Haynes L,Rincon M
Fri Jan 16 00:00:00 EST 2009
Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.
The Journal of experimental medicine
Nolting J,Daniel C,Reuter S,Stuelten C,Li P,Sucov H,Kim BG,Letterio JJ,Kretschmer K,Kim HJ,von Boehmer H
Mon Sep 28 00:00:00 EDT 2009
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Ben-Sasson SZ,Hu-Li J,Quiel J,Cauchetaux S,Ratner M,Shapira I,Dinarello CA,Paul WE
Tue Apr 28 00:00:00 EDT 2009
Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
Journal of immunology (Baltimore, Md. : 1950)
Hamada H,Garcia-Hernandez Mde L,Reome JB,Misra SK,Strutt TM,McKinstry KK,Cooper AM,Swain SL,Dutton RW
Sun Mar 15 00:00:00 EDT 2009
A two-step process for thymic regulatory T cell development.
Immunity
Lio CW,Hsieh CS
Tue Jan 01 00:00:00 EST 2008
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.
Immunity
Hill JA,Hall JA,Sun CM,Cai Q,Ghyselinck N,Chambon P,Belkaid Y,Mathis D,Benoist C
Fri Nov 14 00:00:00 EST 2008
IL-23 promotes maintenance but not commitment to the Th17 lineage.
Journal of immunology (Baltimore, Md. : 1950)
Stritesky GL,Yeh N,Kaplan MH
Sat Nov 01 00:00:00 EDT 2008
