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Product Details
29-8061-65
Applications
Tested Dilution
Publications
Product Specifications
Species
Mouse
Published species
Not Applicable
Expression System
E. coli
Amino acid sequence
Mouse IL-6, amino acids Phe25-Thr211 (Accession # MMINTL6)
Molecular weight
21-28 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
Description: mouse IL-6 (also known as B Cell Stimulating Factor, BCSF, and BSF-2) is a ~21-28 kDa factor produced by a variety of cell types, including monocytes, fibroblasts and endothelial cells. Upon stimulation, macrophages, T, B, mast, and glial cells, eosinophils, keratinocytes and granulocytes also secrete IL-6. This pleiotrophic cytokine influences the antigen-specific immune response, inflammatory response, and the development of neurons, and is a major mediator of the acute phase reaction.
Applications Reported: Mouse IL-6 Lyophilized Standard has been reported for use in the Mouse IL-6 ELISA Ready-SET-Go! Set (Product # 88-7064).
Applications Tested: The intended use of the Mouse IL-6 Lyophilized Standard is as a standard for Mouse IL-6 ELISA (Product # 88-7064-88). Typically the standard is run in a series of 7 doubling dilutions from the 'top' standard. Please refer to the Certificate of Analysis included with each ELISA set for instructions on the proper reconstitution and dilution of the lyophilized standard.
Note: These are single-use vials. Use one time within 4 hours of reconstitution and discard. Reconstitute and dilute as suggested in the Certificate of Analysis or recovery may not be accurate.
Source: E. coli expressed amino acids Phe 25-Thre 211 of mature mouse IL-6 accession # MMINTL6.
Target Information
IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B-cell hybridoma growth factor; H-IL-6; IL-6; ILN; Interleukin; Interleukin HP-1; Interleukin-6; Interleukin6; M-IL-6; R-IL-6
Gene Aliases: Il-6; Il6
UniProt ID: (Mouse) P08505
Entrez Gene ID: (Mouse) 16193
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