Product References
The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.
The Journal of experimental medicine
Krzywinska E,Sobecki M,Nagarajan S,Zacharjasz J,Tambuwala MM,Pelletier A,Cummins E,Gotthardt D,Fandrey J,Kerdiles YM,Peyssonnaux C,Taylor CT,Sexl V,Stockmann C
Mon Feb 07 00:00:00 EST 2022
IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity.
Cell death and differentiation
Das Gupta D,Paul C,Samel N,Bieringer M,Staudenraus D,Marini F,Raifer H,Menke L,Hansal L,Camara B,Roth E,Daum P,Wanzel M,Mernberger M,Nist A,Bauer UM,Helmprobst F,Buchholz M,Roth K,Bastian L,Hartmann AM,Baldus C,Ikuta K,Neubauer A,Burchert A,Jäck HM,Klein M,Bopp T,Stiewe T,Pagenstecher A,Lohoff M
217-17 was used in Cell Culture to present spontaneous leukemogenesis following IRF4 deficiency with potential implications for high-risk BCP-ALL in adult humans.
Tue Nov 01 00:00:00 EDT 2022
Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs.
Frontiers in cell and developmental biology
Lee M,Geitgey DK,Hamilton JAG,Boss JM,Scharer CD,Spangle JM,Haynes KA,Henry CJ
217-17 was used in Sample Preparation (FC/FACS) to investigate T-cell acute lymphoblastic leukemia relationship with obesity in murine models.
Wed Sep 07 00:00:00 EDT 2022
MicroRNA-139 Expression Is Dispensable for the Generation of Influenza-Specific CD8+ T Cell Responses.
Journal of immunology (Baltimore, Md. : 1950)
Hope JL,Zhao M,Stairiker CJ,Kiernan CH,Carey AJ,Mueller YM,van Meurs M,Brouwers-Haspels I,Otero DC,Bae EA,Faso HA,Maas A,de Looper H,Fortina PM,Rigoutsos I,Bradley LM,Erkeland SJ,Katsikis PD
Tue Feb 01 00:00:00 EST 2022
Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function.
Nature communications
Erdogmus S,Concepcion AR,Yamashita M,Sidhu I,Tao AY,Li W,Rocha PP,Huang B,Garippa R,Lee B,Lee A,Hell JW,Lewis RS,Prakriya M,Feske S
217-17 was used in Sample Preparation (FC/FACS) to demonstrate that although CaVβ1 regulates T cell function, these effects are independent of VGCC channel activity.
Tue Apr 19 00:00:00 EDT 2022
Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Nature
Bielecki P,Riesenfeld SJ,Hütter JC,Torlai Triglia E,Kowalczyk MS,Ricardo-Gonzalez RR,Lian M,Amezcua Vesely MC,Kroehling L,Xu H,Slyper M,Muus C,Ludwig LS,Christian E,Tao L,Kedaigle AJ,Steach HR,York AG,Skadow MH,Yaghoubi P,Dionne D,Jarret A,McGee HM,Porter CBM,Licona-Limón P,Bailis W,Jackson R,Gagliani N,Gasteiger G,Locksley RM,Regev A,Flavell RA
217-17 was used in Sample Preparation (FC/FACS) to investigate cytokine production by tissue-resident innate lymphoid cells.
Thu Apr 01 00:00:00 EDT 2021
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.
Nature
Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA
217-17 was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.
Thu Apr 01 00:00:00 EDT 2021
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.
Nature
Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA
217-17 was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.
Thu Apr 01 00:00:00 EDT 2021
Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit.
Nature
Cardoso F,Klein Wolterink RGJ,Godinho-Silva C,Domingues RG,Ribeiro H,da Silva JA,Mahú I,Domingos AI,Veiga-Fernandes H
Wed Sep 01 00:00:00 EDT 2021
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions.
Cell
Huang H,Zhou P,Wei J,Long L,Shi H,Dhungana Y,Chapman NM,Fu G,Saravia J,Raynor JL,Liu S,Palacios G,Wang YD,Qian C,Yu J,Chi H
Thu Mar 04 00:00:00 EST 2021
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions.
Cell
Huang H,Zhou P,Wei J,Long L,Shi H,Dhungana Y,Chapman NM,Fu G,Saravia J,Raynor JL,Liu S,Palacios G,Wang YD,Qian C,Yu J,Chi H
Thu Mar 04 00:00:00 EST 2021
Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells.
Cell research
Liu C,Gong Y,Zhang H,Yang H,Zeng Y,Bian Z,Xin Q,Bai Z,Zhang M,He J,Yan J,Zhou J,Li Z,Ni Y,Wen A,Lan Y,Hu H,Liu B
Fri Oct 01 00:00:00 EDT 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
Tue Jan 12 00:00:00 EST 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
Tue Jan 12 00:00:00 EST 2021
Cold exposure protects from neuroinflammation through immunologic reprogramming.
Cell metabolism
Spiljar M,Steinbach K,Rigo D,Suárez-Zamorano N,Wagner I,Hadadi N,Vincenti I,Page N,Klimek B,Rochat MA,Kreutzfeldt M,Chevalier C,Stojanović O,Bejuy O,Colin D,Mack M,Cansever D,Greter M,Merkler D,Trajkovski M
Tue Nov 02 00:00:00 EDT 2021
Liver X receptor β is required for the survival of single-positive thymocytes by regulating IL-7Rα expression.
Cellular & molecular immunology
Huang H,Wu X,Meng D,Feng Y,Zhou L,Liu Z,Tang S,Li X,Cao Y,He H,Xie Z,Zhang J,Chen Y,Zhao T,Wu Y,Zhou X
217-17 was used in In vivo experiments to indicate that LXRβ functions as an important transcription factor upstream of IL-7Rα to promote the survival of SP thymocytes.
Sun Aug 01 00:00:00 EDT 2021
The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation.
The Journal of experimental medicine
Mori D,Grégoire C,Voisinne G,Celis-Gutierrez J,Aussel R,Girard L,Camus M,Marcellin M,Argenty J,Burlet-Schiltz O,Fiore F,Gonzalez de Peredo A,Malissen M,Roncagalli R,Malissen B
Mon Feb 01 00:00:00 EST 2021
ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice.
The Journal of experimental medicine
Nakajima T,Kanno T,Yokoyama S,Sasamoto S,Asou HK,Tumes DJ,Ohara O,Nakayama T,Endo Y
Mon Dec 06 00:00:00 EST 2021
The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.
The Journal of experimental medicine
Stamos DB,Clubb LM,Mitra A,Chopp LB,Nie J,Ding Y,Das A,Venkataganesh H,Lee J,El-Khoury D,Li L,Bhandoola A,Bosselut R,Love PE
Mon Dec 06 00:00:00 EST 2021
Interferon regulatory factor 4 controls effector functions of CD8+ memory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Harberts A,Schmidt C,Schmid J,Reimers D,Koch-Nolte F,Mittrücker HW,Raczkowski F
Tue Apr 20 00:00:00 EDT 2021
Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity.
Mucosal immunology
Qi X,Qiu J,Chang J,Ji Y,Yang Q,Cui G,Sun L,Chai Q,Qin J,Qiu J
Fri Jan 01 00:00:00 EST 2021
Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity.
Mucosal immunology
Qiu J,Zhang J,Ji Y,Sun H,Gu Z,Sun Q,Bai M,Gong J,Tang J,Zhang Y,Li S,Shao Z,Li J,Sheng H,Shen L,Qiu J
Mon Nov 01 00:00:00 EDT 2021
B Lymphocyte Specification Is Preceded by Extensive Epigenetic Priming in Multipotent Progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Strid T,Okuyama K,Tingvall-Gustafsson J,Kuruvilla J,Jensen CT,Lang S,Prasad M,Somasundaram R,Åhsberg J,Cristobal S,Soneji S,Ungerbäck J,Sigvardsson M
Tue Jun 01 00:00:00 EDT 2021
An optimized protocol for the generation of HBV viral antigen-specific T lymphocytes from pluripotent stem cells.
STAR protocols
Haque M,Xiong X,Lei F,Das JK,Song J
217-17 was used in Cell Culture to describe the generation of hepatitis B virus (HBV) Ag-specific CTLs from induced pluripotent stem cells (iPSCs), i.e., iPSC-CTLs.
Fri Mar 19 00:00:00 EDT 2021
Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation.
eLife
Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS
217-17 was used in In vitro experiments to demonstrate HDAC3 is essential during CD4+ T-cell activation to repress cholesterol efflux.
Thu Dec 02 00:00:00 EST 2021
NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm-/- and old mice HSCs.
NPJ aging and mechanisms of disease
Zong L,Tanaka-Yano M,Park B,Yanai H,Turhan FT,Croteau DL,Tian J,Fang EF,Bohr VA,Beerman I
Tue Sep 21 00:00:00 EDT 2021
IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development.
Scientific reports
Hasegawa H,Mizoguchi I,Orii N,Inoue S,Katahira Y,Yoneto T,Xu M,Miyazaki T,Yoshimoto T
Thu Mar 04 00:00:00 EST 2021
CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy.
Nature communications
Giuffrida L,Sek K,Henderson MA,Lai J,Chen AXY,Meyran D,Todd KL,Petley EV,Mardiana S,Mølck C,Stewart GD,Solomon BJ,Parish IA,Neeson PJ,Harrison SJ,Kats LM,House IG,Darcy PK,Beavis PA
Fri May 28 00:00:00 EDT 2021
Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice.
Cell reports
Kim SP,Srivatsan SN,Chavez M,Shirai CL,White BS,Ahmed T,Alberti MO,Shao J,Nunley R,White LS,Bednarski J,Pehrson JR,Walter MJ
Tue Aug 31 00:00:00 EDT 2021
Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β-selection.
eLife
Liu X,Yu J,Xu L,Umphred-Wilson K,Peng F,Ding Y,Barton BM,Lv X,Zhao MY,Sun S,Hong Y,Qi L,Adoro S,Chen X
217-17 was used in Cell Culture to investigate Notch signaling in ER-associated degradation for proteome integrity in αβ T cells.
Fri Jul 09 00:00:00 EDT 2021
Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma.
Nature communications
Agliardi G,Liuzzi AR,Hotblack A,De Feo D,Núñez N,Stowe CL,Friebel E,Nannini F,Rindlisbacher L,Roberts TA,Ramasawmy R,Williams IP,Siow BM,Lythgoe MF,Kalber TL,Quezada SA,Pule MA,Tugues S,Straathof K,Becher B
Tue Jan 19 00:00:00 EST 2021
Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma.
Scientific reports
Akasu M,Shimada S,Kabashima A,Akiyama Y,Shimokawa M,Akahoshi K,Kudo A,Yamaoka S,Tanabe M,Tanaka S
Tue Aug 24 00:00:00 EDT 2021
Lymphocyte access to lymphoma is impaired by high endothelial venule regression.
Cell reports
Menzel L,Zschummel M,Crowley T,Franke V,Grau M,Ulbricht C,Hauser A,Siffrin V,Bajénoff M,Acton SE,Akalin A,Lenz G,Willimsky G,Höpken UE,Rehm A
Tue Oct 26 00:00:00 EDT 2021
CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Nature communications
Bunse M,Pfeilschifter J,Bluhm J,Zschummel M,Joedicke JJ,Wirges A,Stark H,Kretschmer V,Chmielewski M,Uckert W,Abken H,Westermann J,Rehm A,Höpken UE
Mon Jan 11 00:00:00 EST 2021
Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia.
Nature communications
Van Thillo Q,De Bie J,Seneviratne JA,Demeyer S,Omari S,Balachandran A,Zhai V,Tam WL,Sweron B,Geerdens E,Gielen O,Provost S,Segers H,Boeckx N,Marshall GM,Cheung BB,Isobe K,Kato I,Takita J,Amos TG,Deveson IW,McCalmont H,Lock RB,Oxley EP,Garwood MM,Dickins RA,Uyttebroeck A,Carter DR,Cools J,de Bock CE
Tue Jul 06 00:00:00 EDT 2021
Divergent fates of antigen-specific CD8+ T cell clones in mice with acute leukemia.
Cell reports
Chen X,MacNabb BW,Flood B,Blazar BR,Kline J
217-17 was used in Sample Preparation to reveal that leukemia antigens are presented to CD8+ T cells via discrete pathways, leading to distinct tolerant states.
Tue Nov 09 00:00:00 EST 2021
Soluble CD127 potentiates IL-7 activity in vivo in healthy mice.
Immunity, inflammation and disease
Aloufi NA,Ali AK,Burke Schinkel SC,Molyer B,Barros PO,McBane JE,Lee SH,Angel JB
Wed Dec 01 00:00:00 EST 2021
Chromosomal coordination and differential structure of asynchronous replicating regions.
Nature communications
Blumenfeld B,Masika H,Farago M,Yehuda Y,Halaseh L,Vardi O,Rapoport R,Levin-Klein R,Cedar H,Bergman Y,Simon I
Mon Feb 15 00:00:00 EST 2021
PPAR¿ drives IL-33-dependent ILC2 pro-tumoral functions.
Nature communications
Ercolano G,Gomez-Cadena A,Dumauthioz N,Vanoni G,Kreutzfeldt M,Wyss T,Michalik L,Loyon R,Ianaro A,Ho PC,Borg C,Kopf M,Merkler D,Krebs P,Romero P,Trabanelli S,Jandus C
Wed May 05 00:00:00 EDT 2021
Tunable, division-independent control of gene activation timing by a polycomb switch.
Cell reports
Pease NA,Nguyen PHB,Woodworth MA,Ng KKH,Irwin B,Vaughan JC,Kueh HY
Tue Mar 23 00:00:00 EDT 2021
Retracted: Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2.
Cell
Morita K,He S,Nowak RP,Wang J,Zimmerman MW,Fu C,Durbin AD,Martel MW,Prutsch N,Gray NS,Fischer ES,Look AT
Thu Apr 30 00:00:00 EDT 2020
Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics.
Immunity
Zenke S,Palm MM,Braun J,Gavrilov A,Meiser P,Böttcher JP,Beyersdorf N,Ehl S,Gerard A,Lämmermann T,Schumacher TN,Beltman JB,Rohr JC
Tue Feb 18 00:00:00 EST 2020
Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues.
Immunity
Guendel F,Kofoed-Branzk M,Gronke K,Tizian C,Witkowski M,Cheng HW,Heinz GA,Heinrich F,Durek P,Norris PS,Ware CF,Ruedl C,Herold S,Pfeffer K,Hehlgans T,Waisman A,Becher B,Giannou AD,Brachs S,Ebert K,Tanriver Y,Ludewig B,Mashreghi MF,Kruglov AA,Diefenbach A
Tue Nov 17 00:00:00 EST 2020
In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors.
Immunity
Zeis P,Lian M,Fan X,Herman JS,Hernandez DC,Gentek R,Elias S,Symowski C,Knöpper K,Peltokangas N,Friedrich C,Doucet-Ladeveze R,Kabat AM,Locksley RM,Voehringer D,Bajenoff M,Rudensky AY,Romagnani C,Grün D,Gasteiger G
Tue Oct 13 00:00:00 EDT 2020
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Cancer cell
Witkowski MT,Dolgalev I,Evensen NA,Ma C,Chambers T,Roberts KG,Sreeram S,Dai Y,Tikhonova AN,Lasry A,Qu C,Pei D,Cheng C,Robbins GA,Pierro J,Selvaraj S,Mezzano V,Daves M,Lupo PJ,Scheurer ME,Loomis CA,Mullighan CG,Chen W,Rabin KR,Tsirigos A,Carroll WL,Aifantis I
Mon Jun 08 00:00:00 EDT 2020
Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis.
Cell metabolism
LaMarche NM,Kane H,Kohlgruber AC,Dong H,Lynch L,Brenner MB
217-17 was used in Cell Culture to utilize non-redundant pathways to preserve metabolic integrity.
Tue Aug 04 00:00:00 EDT 2020
Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.
Cell metabolism
Roy DG,Chen J,Mamane V,Ma EH,Muhire BM,Sheldon RD,Shorstova T,Koning R,Johnson RM,Esaulova E,Williams KS,Hayes S,Steadman M,Samborska B,Swain A,Daigneault A,Chubukov V,Roddy TP,Foulkes W,Pospisilik JA,Bourgeois-Daigneault MC,Artyomov MN,Witcher M,Krawczyk CM,Larochelle C,Jones RG
217-17 was used in In vitro experiments to investigate the role of methionine on CD4+ T helper cells.
Tue Feb 04 00:00:00 EST 2020
Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia.
Blood
Gang EJ,Kim HN,Hsieh YT,Ruan Y,Ogana HA,Lee S,Pham J,Geng H,Park E,Klemm L,Willman CL,Carroll WL,Mittelman SD,Orgel E,Oberley MJ,Parekh C,Abdel-Azim H,Bhojwani D,Wayne AS,De Arcangelis A,Georges-Labouesse E,Wayner E,Bonig H,Minasyan A,Ten Hoeve J,Graeber TG,Müschen M,Heisterkamp N,Kim YM
Thu Jul 09 00:00:00 EDT 2020
Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes.
The Journal of clinical investigation
Meyer LK,Huang BJ,Delgado-Martin C,Roy RP,Hechmer A,Wandler AM,Vincent TL,Fortina P,Olshen AB,Wood BL,Horton TM,Shannon KM,Teachey DT,Hermiston ML
Mon Feb 03 00:00:00 EST 2020
Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL.
The Journal of clinical investigation
Hurtz C,Wertheim GB,Loftus JP,Blumenthal D,Lehman A,Li Y,Bagashev A,Manning B,Cummins KD,Burkhardt JK,Perl AE,Carroll M,Tasian SK
Wed Jul 01 00:00:00 EDT 2020
A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool.
The Journal of experimental medicine
Kok L,Dijkgraaf FE,Urbanus J,Bresser K,Vredevoogd DW,Cardoso RF,Perié L,Beltman JB,Schumacher TN
Mon Oct 05 00:00:00 EDT 2020
Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions.
The Journal of experimental medicine
Raynor JL,Liu C,Dhungana Y,Guy C,Chapman NM,Shi H,Neale G,Sesaki H,Chi H
Mon Jun 01 00:00:00 EDT 2020
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.
The EMBO journal
Wiede F,Lu KH,Du X,Liang S,Hochheiser K,Dodd GT,Goh PK,Kearney C,Meyran D,Beavis PA,Henderson MA,Park SL,Waithman J,Zhang S,Zhang ZY,Oliaro J,Gebhardt T,Darcy PK,Tiganis T
Wed Jan 15 00:00:00 EST 2020
NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling.
Oncogene
Pinto I,Duque M,Gonçalves J,Akkapeddi P,Oliveira ML,Cabrita R,Yunes JA,Durum SK,Barata JT,Fragoso R
Wed Jan 01 00:00:00 EST 2020
γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis.
Mucosal immunology
Monin L,Ushakov DS,Arnesen H,Bah N,Jandke A,Muñoz-Ruiz M,Carvalho J,Joseph S,Almeida BC,Green MJ,Nye E,Hatano S,Yoshikai Y,Curtis M,Carlsen H,Steinhoff U,Boysen P,Hayday A
Sun Nov 01 00:00:00 EDT 2020
Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development.
The Journal of cell biology
Romero-Wolf M,Shin B,Zhou W,Koizumi M,Rothenberg EV,Hosokawa H
Mon Oct 05 00:00:00 EDT 2020
A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Oba T,Hoki T,Yamauchi T,Keler T,Marsh HC,Cao X,Ito F
Thu Oct 01 00:00:00 EDT 2020
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Journal of immunology (Baltimore, Md. : 1950)
Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D
Thu Oct 15 00:00:00 EDT 2020
Rapid Death of Follicular B Cells and Burkitt Lymphoma Cells Effectuated by Xbp1s.
Journal of immunology (Baltimore, Md. : 1950)
Chen YT,Kung JT
Mon Jun 15 00:00:00 EDT 2020
E3 Ubiquitin Ligase Fbw7 Regulates the Survival of Mature B Cells.
Journal of immunology (Baltimore, Md. : 1950)
Ramezani-Rad P,Leung CR,Apgar JR,Rickert RC
Sun Mar 15 00:00:00 EDT 2020
The Abundance and Availability of Cytokine Receptor IL-2Rβ (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Keller HR,Kim HK,Jo Y,Gress RE,Hong C,Park JH
Mon Jun 15 00:00:00 EDT 2020
p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells.
Scientific reports
Petrova T,Pesic J,Pardali K,Gaestel M,Arthur JSC
Wed Feb 26 00:00:00 EST 2020
A mouse model that is immunologically tolerant to reporter and modifier proteins.
Communications biology
Bresser K,Dijkgraaf FE,Pritchard CEJ,Huijbers IJ,Song JY,Rohr JC,Scheeren FA,Schumacher TN
Fri May 29 00:00:00 EDT 2020
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Nature communications
Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ
217-17 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.
Fri Dec 04 00:00:00 EST 2020
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Nature communications
Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ
217-17 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.
Fri Dec 04 00:00:00 EST 2020
Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.
Science advances
Pessoa Rodrigues C,Herman JS,Herquel B,Valsecchi CIK,Stehle T,Grün D,Akhtar A
217-17 was used in In vitro experiments to study the mechanism by which histone H4 lysine 16 acetyltransferase MOF regulates erythropoiesis.
Fri May 01 00:00:00 EDT 2020
Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen species.
Scientific reports
Lepez A,Pirnay T,Denanglaire S,Perez-Morga D,Vermeersch M,Leo O,Andris F
Thu Dec 10 00:00:00 EST 2020
Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.
Nature communications
Oatley M,Bölükbası ÖV,Svensson V,Shvartsman M,Ganter K,Zirngibl K,Pavlovich PV,Milchevskaya V,Foteva V,Natarajan KN,Baying B,Benes V,Patil KR,Teichmann SA,Lancrin C
217-17 was used in In vitro experiments to demonstrate that by inhibiting the interaction between CD44 and its ligand hyaluronan, we can block EHT, identifying an additional regulator of HSPC development.
Wed Jan 29 00:00:00 EST 2020
A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.
Cell reports
Donado CA,Cao AB,Simmons DP,Croker BA,Brennan PJ,Brenner MB
217-17 was used in Cell Culture to describe an alternative, two-cell model for IL-1β release where invariant natural killer T (iNKT) cells use the death receptor pathway to instruct antigen-presenting cells to secrete IL-1β.
Tue Apr 07 00:00:00 EDT 2020
In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells.
Cell reports
Montel-Hagen A,Sun V,Casero D,Tsai S,Zampieri A,Jackson N,Li S,Lopez S,Zhu Y,Chick B,He C,de Barros SC,Seet CS,Crooks GM
Tue Oct 27 00:00:00 EDT 2020
In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells.
Cell reports
Montel-Hagen A,Sun V,Casero D,Tsai S,Zampieri A,Jackson N,Li S,Lopez S,Zhu Y,Chick B,He C,de Barros SC,Seet CS,Crooks GM
Tue Oct 27 00:00:00 EDT 2020
Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species.
Science advances
Kong H,Reczek CR,McElroy GS,Steinert EM,Wang T,Sabatini DM,Chandel NS
217-17 was used in Cell Culture to demonstrate that mitochondrial complex I is a dominant metabolic determinant of mROS-dependent cellular fitness, using mitochondria-targeted antioxidants (MVE or MitoTEMPO) to pharmcologically inhibit mitochondrial complex I.
Sun Nov 01 00:00:00 EDT 2020
T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice.
Scientific reports
Mullins GN,Valentine KM,Al-Kuhlani M,Davini D,Jensen KDC,Hoyer KK
Tue Dec 15 00:00:00 EST 2020
Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells.
Immunity
Ma EH,Verway MJ,Johnson RM,Roy DG,Steadman M,Hayes S,Williams KS,Sheldon RD,Samborska B,Kosinski PA,Kim H,Griss T,Faubert B,Condotta SA,Krawczyk CM,DeBerardinis RJ,Stewart KM,Richer MJ,Chubukov V,Roddy TP,Jones RG
Tue Nov 19 00:00:00 EST 2019
Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β.
Immunity
Komuczki J,Tuzlak S,Friebel E,Hartwig T,Spath S,Rosenstiel P,Waisman A,Opitz L,Oukka M,Schreiner B,Pelczar P,Becher B
217-17 was used in In vitro experiments to investigate pathogenic lymphocyte in chronic inflammatory disease.
Tue May 21 00:00:00 EDT 2019
Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells.
Immunity
Mariani SA,Li Z,Rice S,Krieg C,Fragkogianni S,Robinson M,Vink CS,Pollard JW,Dzierzak E
Tue Jun 18 00:00:00 EDT 2019
γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia.
Cancer cell
Luong-Gardiol N,Siddiqui I,Pizzitola I,Jeevan-Raj B,Charmoy M,Huang Y,Irmisch A,Curtet S,Angelov GS,Danilo M,Juilland M,Bornhauser B,Thome M,Hantschel O,Chalandon Y,Cazzaniga G,Bourquin JP,Huelsken J,Held W
Mon Apr 15 00:00:00 EDT 2019
Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity.
Blood
Weijenborg Campos L,Pini Zenatti P,Granato Pissinato L,Libanio Rodrigues GO,Artico LL,Rafael Guimarães T,Fröhlich Archangelo L,Martínez L,Brooks AJ,Yunes JA
Thu Mar 14 00:00:00 EDT 2019
Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity.
Blood
Weijenborg Campos L,Pini Zenatti P,Granato Pissinato L,Libanio Rodrigues GO,Artico LL,Rafael Guimarães T,Fröhlich Archangelo L,Martínez L,Brooks AJ,Yunes JA
Thu Mar 14 00:00:00 EDT 2019
Chimeric antigen receptor-induced BCL11B suppression propagates NK-like cell development.
The Journal of clinical investigation
Maluski M,Ghosh A,Herbst J,Scholl V,Baumann R,Huehn J,Geffers R,Meyer J,Maul H,Eiz-Vesper B,Krueger A,Schambach A,van den Brink MR,Sauer MG
Mon Dec 02 00:00:00 EST 2019
The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control.
The Journal of experimental medicine
Zhu Y,Zhao Y,Zou L,Zhang D,Aki D,Liu YC
Mon Jul 01 00:00:00 EDT 2019
Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection.
Proceedings of the National Academy of Sciences of the United States of America
Zheng M,Li D,Zhao Z,Shytikov D,Xu Q,Jin X,Liang J,Lou J,Wu S,Wang L,Hu H,Zhou Y,Gao X,Lu L
Tue Jun 18 00:00:00 EDT 2019
SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors.
Journal of immunology (Baltimore, Md. : 1950)
Pfeifer M,Brem R,Lippert TP,Boulianne B,Ho HN,Robinson ME,Stebbing J,Feldhahn N
Sat Jun 15 00:00:00 EDT 2019
Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development.
Cell death & disease
Gong Z,Shang B,Chu Y,Chen X,Li Q,Liu K,Chen Y,Huang Y,Han Y,Shang Q,Zheng Z,Song L,Li Y,Liu R,Xu C,Zhang X,Liu B,Wang L,Shao C,Wang Y,Shi Y
Wed Jun 05 00:00:00 EDT 2019
Blocked O-GlcNAc cycling disrupts mouse hematopoeitic stem cell maintenance and early T cell development.
Scientific reports
Abramowitz LK,Harly C,Das A,Bhandoola A,Hanover JA
Thu Aug 29 00:00:00 EDT 2019
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.
Nature communications
Kusakabe M,Sun AC,Tyshchenko K,Wong R,Nanda A,Shanna C,Gusscott S,Chavez EA,Lorzadeh A,Zhu A,Hill A,Hung S,Brown S,Babaian A,Wang X,Holt RA,Steidl C,Karsan A,Humphries RK,Eaves CJ,Hirst M,Weng AP
Tue Jul 02 00:00:00 EDT 2019
Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation.
Nature communications
Miyamoto C,Kojo S,Yamashita M,Moro K,Lacaud G,Shiroguchi K,Taniuchi I,Ebihara T
Fri Jan 25 00:00:00 EST 2019
Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis.
Nature communications
Lee HG,Lee JU,Kim DH,Lim S,Kang I,Choi JM
Tue Feb 12 00:00:00 EST 2019
Long-Term Engraftment of ESC-Derived B-1 Progenitor Cells Supports HSC-Independent Lymphopoiesis.
Stem cell reports
Lin Y,Kobayashi M,Azevedo Portilho N,Mishra A,Gao H,Liu Y,Wenzel P,Davis B,Yoder MC,Yoshimoto M
Tue Mar 05 00:00:00 EST 2019
Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity.
Journal for immunotherapy of cancer
Miret JJ,Kirschmeier P,Koyama S,Zhu M,Li YY,Naito Y,Wu M,Malladi VS,Huang W,Walker W,Palakurthi S,Dranoff G,Hammerman PS,Pecot CV,Wong KK,Akbay EA
217-17 was used in Cell Culture to suggest arginase as an immunomodulatory target that should further be investigated in lung tumors with high arginase activity.
Wed Feb 06 00:00:00 EST 2019
Senescence-associated reprogramming promotes cancer stemness.
Nature
Milanovic M,Fan DNY,Belenki D,Däbritz JHM,Zhao Z,Yu Y,Dörr JR,Dimitrova L,Lenze D,Monteiro Barbosa IA,Mendoza-Parra MA,Kanashova T,Metzner M,Pardon K,Reimann M,Trumpp A,Dörken B,Zuber J,Gronemeyer H,Hummel M,Dittmar G,Lee S,Schmitt CA
Thu Jan 04 00:00:00 EST 2018
Clonal analysis of lineage fate in native haematopoiesis.
Nature
Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD
Thu Jan 11 00:00:00 EST 2018
B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies.
Cell
Xiao G,Chan LN,Klemm L,Braas D,Chen Z,Geng H,Zhang QC,Aghajanirefah A,Cosgun KN,Sadras T,Lee J,Mirzapoiazova T,Salgia R,Ernst T,Hochhaus A,Jumaa H,Jiang X,Weinstock DM,Graeber TG,Müschen M
Thu Apr 05 00:00:00 EDT 2018
The Majority of CD45- Ter119- CD31- Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors.
Immunity
Boulais PE,Mizoguchi T,Zimmerman S,Nakahara F,Vivié J,Mar JC,van Oudenaarden A,Frenette PS
Tue Oct 16 00:00:00 EDT 2018
The Majority of CD45- Ter119- CD31- Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors.
Immunity
Boulais PE,Mizoguchi T,Zimmerman S,Nakahara F,Vivié J,Mar JC,van Oudenaarden A,Frenette PS
Tue Oct 16 00:00:00 EDT 2018
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
Tue Feb 20 00:00:00 EST 2018
Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function.
Immunity
Li S,Bostick JW,Ye J,Qiu J,Zhang B,Urban JF,Avram D,Zhou L
Tue Nov 20 00:00:00 EST 2018
Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Vanden Bempt M,Demeyer S,Broux M,De Bie J,Bornschein S,Mentens N,Vandepoel R,Geerdens E,Radaelli E,Bornhauser BC,Kulozik AE,Meijerink JP,Bourquin JP,de Bock CE,Cools J
Mon Aug 13 00:00:00 EDT 2018
RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis.
Cancer cell
Cortes JR,Ambesi-Impiombato A,Couronné L,Quinn SA,Kim CS,da Silva Almeida AC,West Z,Belver L,Martin MS,Scourzic L,Bhagat G,Bernard OA,Ferrando AA,Palomero T
Mon Feb 12 00:00:00 EST 2018
Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.
The Journal of experimental medicine
Tober J,Maijenburg MMW,Li Y,Gao L,Hadland BK,Gao P,Minoura K,Bernstein ID,Tan K,Speck NA
Mon Feb 05 00:00:00 EST 2018
Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.
The Journal of experimental medicine
Jensen CT,Åhsberg J,Sommarin MNE,Strid T,Somasundaram R,Okuyama K,Ungerbäck J,Kupari J,Airaksinen MS,Lang S,Bryder D,Soneji S,Karlsson G,Sigvardsson M
Mon Jul 02 00:00:00 EDT 2018
Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells.
Oncogene
Pinazza M,Ghisi M,Minuzzo S,Agnusdei V,Fossati G,Ciminale V,Pezzè L,Ciribilli Y,Pilotto G,Venturoli C,Amadori A,Indraccolo S
Sun Jul 01 00:00:00 EDT 2018
Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wang Y,Xiao M,Tao C,Chen J,Wang Z,Yang J,Chen Z,Zou Z,Liu A,Cai D,Jiang Y,Ding C,Li M,Bai X
217-17 was used in In vivo experiments to demonstrate a novel role for mechanistic target of rapamycin complex 1 in the regulation of bone marrow environments that support B-cell differentiation via regulating IL-7 expression.
Sun Apr 01 00:00:00 EDT 2018
Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells.
Journal of immunology (Baltimore, Md. : 1950)
Ferdinand JR,Richard AC,Meylan F,Al-Shamkhani A,Siegel RM
Thu Feb 15 00:00:00 EST 2018
MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Gan T,Li BE,Mishra BP,Jones KL,Ernst P
Thu Mar 01 00:00:00 EST 2018
Glucocorticoids Inhibit Group 3 Innate Lymphocyte IL-22 Production.
Journal of immunology (Baltimore, Md. : 1950)
Seshadri S,Pope RL,Zenewicz LA
Wed Aug 15 00:00:00 EDT 2018
Mesenchymal Stromal Cells Stimulate the Proliferation and IL-22 Production of Group 3 Innate Lymphoid Cells.
Journal of immunology (Baltimore, Md. : 1950)
van Hoeven V,Munneke JM,Cornelissen AS,Omar SZ,Spruit MJ,Kleijer M,Bernink JH,Blom B,Voermans C,Hazenberg MD
Wed Aug 15 00:00:00 EDT 2018
B Cell Development sans B Cell Receptor Responsiveness Due to Unfolded Protein Response-Triggered Mef2c Protein Degradation.
Journal of immunology (Baltimore, Md. : 1950)
Chen YT,Su YC,Kung JT
Thu Nov 15 00:00:00 EST 2018
Progression from the Common Lymphoid Progenitor to B/Myeloid PreproB and ProB Precursors during B Lymphopoiesis Requires C/EBPα.
Journal of immunology (Baltimore, Md. : 1950)
Guo H,Barberi T,Suresh R,Friedman AD
Sat Sep 15 00:00:00 EDT 2018
IVIg Promote Cross-Tolerance against Inflammatory Stimuli In Vitro and In Vivo.
Journal of immunology (Baltimore, Md. : 1950)
Domínguez-Soto Á,Simón-Fuentes M,de Las Casas-Engel M,Cuevas VD,López-Bravo M,Domínguez-Andrés J,Saz-Leal P,Sancho D,Ardavín C,Ochoa-Grullón J,Sánchez-Ramón S,Vega MA,Corbí AL
Sun Jul 01 00:00:00 EDT 2018
Novel TCR-Mediated Mechanisms of Notch Activation and Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Steinbuck MP,Arakcheeva K,Winandy S
Thu Feb 01 00:00:00 EST 2018
Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Bhatt B,Zeng P,Zhu H,Sivaprakasam S,Li S,Xiao H,Dong L,Shiao P,Kolhe R,Patel N,Li H,Levy-Bercowski D,Ganapathy V,Singh N
Sun Apr 15 00:00:00 EDT 2018
TCF-1 Inhibits IL-17 Gene Expression To Restrain Th17 Immunity in a Stage-Specific Manner.
Journal of immunology (Baltimore, Md. : 1950)
Zhang J,He Z,Sen S,Wang F,Zhang Q,Sun Z
Tue May 15 00:00:00 EDT 2018
Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Kostrzewski T,Borg AJ,Meng Y,Filipovic I,Male V,Wack A,DiMaggio PA,Brady HJM
Thu Feb 15 00:00:00 EST 2018
c-Myb Coordinates Survival and the Expression of Genes That Are Critical for the Pre-BCR Checkpoint.
Journal of immunology (Baltimore, Md. : 1950)
Fahl SP,Daamen AR,Crittenden RB,Bender TP
Tue May 15 00:00:00 EDT 2018
Angiotensin II-induced Hypertension is Reduced by Deficiency of P-selectin Glycoprotein Ligand-1.
Scientific reports
Wang Q,Wang H,Wang J,Venugopal J,Kleiman K,Guo C,Sun Y,Eitzman DT
Mon Feb 19 00:00:00 EST 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
217-17 was used in Cell Culture to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 EDT 2018
Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells.
Nature communications
Tremblay CS,Saw J,Chiu SK,Wong NC,Tsyganov K,Ghotb S,Graham AN,Yan F,Guirguis AA,Sonderegger SE,Lee N,Kalitsis P,Reynolds J,Ting SB,Powell DR,Jane SM,Curtis DJ
217-17 was used in Sample Preparation (FC/FACS) to conclude that inducing proliferation of pre-LSCs represents a promising strategy to increase cure rates for acute leukemia.
Thu Aug 30 00:00:00 EDT 2018
Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells.
Nature communications
Tremblay CS,Saw J,Chiu SK,Wong NC,Tsyganov K,Ghotb S,Graham AN,Yan F,Guirguis AA,Sonderegger SE,Lee N,Kalitsis P,Reynolds J,Ting SB,Powell DR,Jane SM,Curtis DJ
217-17 was used in Sample Preparation (FC/FACS) to conclude that inducing proliferation of pre-LSCs represents a promising strategy to increase cure rates for acute leukemia.
Thu Aug 30 00:00:00 EDT 2018
DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells.
Nature communications
Yamamoto T,Endo Y,Onodera A,Hirahara K,Asou HK,Nakajima T,Kanno T,Ouchi Y,Uematsu S,Nishimasu H,Nureki O,Tumes DJ,Shimojo N,Nakayama T
Fri Oct 12 00:00:00 EDT 2018
Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity.
Nature communications
Zhang Y,Li N,Suh H,Irvine DJ
Tue Jan 02 00:00:00 EST 2018
Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate.
Cell stem cell
Sardina JL,Collombet S,Tian TV,Gómez A,Di Stefano B,Berenguer C,Brumbaugh J,Stadhouders R,Segura-Morales C,Gut M,Gut IG,Heath S,Aranda S,Di Croce L,Hochedlinger K,Thieffry D,Graf T
217-17 was used in Cell Culture to report DNA methylation and hydroxymethylation dynamics at nucleotide resolution using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs).
Thu Nov 01 00:00:00 EDT 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
Tue Oct 09 00:00:00 EDT 2018
CDK4/6 inhibition triggers anti-tumour immunity.
Nature
Goel S,DeCristo MJ,Watt AC,BrinJones H,Sceneay J,Li BB,Khan N,Ubellacker JM,Xie S,Metzger-Filho O,Hoog J,Ellis MJ,Ma CX,Ramm S,Krop IE,Winer EP,Roberts TM,Kim HJ,McAllister SS,Zhao JJ
Thu Aug 24 00:00:00 EDT 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
217-17 was used in Sample Preparation (FC/FACS) to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 EDT 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
217-17 was used in Sample Preparation (FC/FACS) to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 EDT 2017
Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Immunity
Fu B,Zhou Y,Ni X,Tong X,Xu X,Dong Z,Sun R,Tian Z,Wei H
217-17 was used in In vitro experiments to reveal properties of Natural Killer (NK) cells in promoting fetal growth.
Tue Dec 19 00:00:00 EST 2017
SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells.
Immunity
Stephen TL,Payne KK,Chaurio RA,Allegrezza MJ,Zhu H,Perez-Sanz J,Perales-Puchalt A,Nguyen JM,Vara-Ailor AE,Eruslanov EB,Borowsky ME,Zhang R,Laufer TM,Conejo-Garcia JR
Tue Jan 17 00:00:00 EST 2017
Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.
Immunity
Minutti CM,Drube S,Blair N,Schwartz C,McCrae JC,McKenzie AN,Kamradt T,Mokry M,Coffer PJ,Sibilia M,Sijts AJ,Fallon PG,Maizels RM,Zaiss DM
Tue Oct 17 00:00:00 EDT 2017
The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.
Immunity
Miyazaki M,Miyazaki K,Chen K,Jin Y,Turner J,Moore AJ,Saito R,Yoshida K,Ogawa S,Rodewald HR,Lin YC,Kawamoto H,Murre C
Tue May 16 00:00:00 EDT 2017
Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.
Immunity
Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S
Tue Oct 17 00:00:00 EDT 2017
Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.
Cancer cell
Spranger S,Dai D,Horton B,Gajewski TF
Mon May 08 00:00:00 EDT 2017
Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies.
The Journal of experimental medicine
Tanaka T,Nakajima-Takagi Y,Aoyama K,Tara S,Oshima M,Saraya A,Koide S,Si S,Manabe I,Sanada M,Nakayama M,Masuko M,Sone H,Koseki H,Iwama A
Mon Oct 02 00:00:00 EDT 2017
PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.
The Journal of experimental medicine
Wiede F,Dudakov JA,Lu KH,Dodd GT,Butt T,Godfrey DI,Strasser A,Boyd RL,Tiganis T
Mon Sep 04 00:00:00 EDT 2017
Distinct PKC-mediated posttranscriptional events set cytokine production kinetics in CD8+ T cells.
Proceedings of the National Academy of Sciences of the United States of America
Salerno F,Paolini NA,Stark R,von Lindern M,Wolkers MC
Tue Sep 05 00:00:00 EDT 2017
Generation of an osteoblast-based artificial niche that supports in vitro B lymphopoiesis.
Experimental & molecular medicine
Yu J,Choi S,Kim H,Lee N,Yun H,Kim S,Jeong ST,Rho J
Fri Nov 24 00:00:00 EST 2017
A defined metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1.
Cell death and differentiation
Stein M,Dütting S,Mougiakakos D,Bösl M,Fritsch K,Reimer D,Urbanczyk S,Steinmetz T,Schuh W,Bozec A,Winkler TH,Jäck HM,Mielenz D
217-17 was used in Cell Culture to investigate the step regulating the metabolic switch from pro to pre B cells.
Sat Jul 01 00:00:00 EDT 2017
Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Hayashi T,Nakachi K,Moore MA,van den Brink MRM,Kusunoki Y
Sun Oct 15 00:00:00 EDT 2017
Absence of Grail promotes CD8+ T cell anti-tumour activity.
Nature communications
Haymaker C,Yang Y,Wang J,Zou Q,Sahoo A,Alekseev A,Singh D,Ritthipichai K,Hailemichael Y,Hoang ON,Qin H,Schluns KS,Wang T,Overwijk WW,Sun SC,Bernatchez C,Kwak LW,Neelapu SS,Nurieva R
Thu Aug 10 00:00:00 EDT 2017
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Fri Sep 29 00:00:00 EDT 2017
Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay.
Scientific reports
Ko JS,Koh JM,So JS,Jeon YK,Kim HY,Chung DH
Thu Nov 02 00:00:00 EDT 2017
IL-15 sustains IL-7R-independent ILC2 and ILC3 development.
Nature communications
Robinette ML,Bando JK,Song W,Ulland TK,Gilfillan S,Colonna M
Fri Mar 31 00:00:00 EDT 2017
IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development.
Nature communications
Liu B,Ye B,Zhu X,Huang G,Yang L,Zhu P,Du Y,Wu J,Meng S,Tian Y,Fan Z
Thu Aug 10 00:00:00 EDT 2017
TC-PTP regulates the IL-7 transcriptional response during murine early T cell development.
Scientific reports
Pike KA,Hatzihristidis T,Bussières-Marmen S,Robert F,Desai N,Miranda-Saavedra D,Pelletier J,Tremblay ML
Mon Oct 16 00:00:00 EDT 2017
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes.
Nature
Verbist KC,Guy CS,Milasta S,Liedmann S,Kamiński MM,Wang R,Green DR
217-17 was used in In vitro experiments to investigate the mechanisms that sustain differential cell fates in daughter T cells after activation by an antigen-presenting cell.
Thu Apr 21 00:00:00 EDT 2016
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.
Nature biotechnology
Stevens MM,Maire CL,Chou N,Murakami MA,Knoff DS,Kikuchi Y,Kimmerling RJ,Liu H,Haidar S,Calistri NL,Cermak N,Olcum S,Cordero NA,Idbaih A,Wen PY,Weinstock DM,Ligon KL,Manalis SR
217-17 was used in In vitro experiments to investigate assays for tumour cell therapeutic response.
Tue Nov 01 00:00:00 EDT 2016
Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.
Immunity
Kristiansen TA,Jaensson Gyllenbäck E,Zriwil A,Björklund T,Daniel JA,Sitnicka E,Soneji S,Bryder D,Yuan J
Tue Aug 16 00:00:00 EDT 2016
LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
The Journal of clinical investigation
Cheng Y,Chikwava K,Wu C,Zhang H,Bhagat A,Pei D,Choi JK,Tong W
Fri Apr 01 00:00:00 EDT 2016
Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging.
The Journal of experimental medicine
Young K,Borikar S,Bell R,Kuffler L,Philip V,Trowbridge JJ
Mon Oct 17 00:00:00 EDT 2016
Unstable FoxP3+ T regulatory cells in NZW mice.
Proceedings of the National Academy of Sciences of the United States of America
Dépis F,Kwon HK,Mathis D,Benoist C
Tue Feb 02 00:00:00 EST 2016
CXCR4 Signaling Negatively Modulates the Bipotential State of Hemogenic Endothelial Cells Derived from Embryonic Stem Cells by Attenuating the Endothelial Potential.
Stem cells (Dayton, Ohio)
Ahmed T,Tsuji-Tamura K,Ogawa M
Thu Dec 01 00:00:00 EST 2016
IL-12 Signals through the TCR To Support CD8 Innate Immune Responses.
Journal of immunology (Baltimore, Md. : 1950)
Goplen NP,Saxena V,Knudson KM,Schrum AG,Gil D,Daniels MA,Zamoyska R,Teixeiro E
Thu Sep 15 00:00:00 EDT 2016
Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Corpuz TM,Stolp J,Kim HO,Pinget GV,Gray DH,Cho JH,Sprent J,Webster KE
Fri Jan 15 00:00:00 EST 2016
Intratumorally Establishing Type 2 Innate Lymphoid Cells Blocks Tumor Growth.
Journal of immunology (Baltimore, Md. : 1950)
Kim J,Kim W,Moon UJ,Kim HJ,Choi HJ,Sin JI,Park NH,Cho HR,Kwon B
Tue Mar 01 00:00:00 EST 2016
TLR-Mediated Innate Production of IFN-γ by CD8+ T Cells Is Independent of Glycolysis.
Journal of immunology (Baltimore, Md. : 1950)
Salerno F,Guislain A,Cansever D,Wolkers MC
Sun May 01 00:00:00 EDT 2016
Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in Mice.
Journal of immunology (Baltimore, Md. : 1950)
von Wnuck Lipinski K,Sattler K,Peters S,Weske S,Keul P,Klump H,Heusch G,Göthert JR,Levkau B
Mon Feb 15 00:00:00 EST 2016
Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in Mice.
Journal of immunology (Baltimore, Md. : 1950)
von Wnuck Lipinski K,Sattler K,Peters S,Weske S,Keul P,Klump H,Heusch G,Göthert JR,Levkau B
Mon Feb 15 00:00:00 EST 2016
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Nature communications
Gomez-Rodriguez J,Meylan F,Handon R,Hayes ET,Anderson SM,Kirby MR,Siegel RM,Schwartzberg PL
217-17 was used in Cell Culture to investigate the role of IL-9 in allergic asthma and autoimmunity, showing that Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Thu Mar 03 00:00:00 EST 2016
Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity.
Scientific reports
Haque M,Song J,Fino K,Sandhu P,Song X,Lei F,Zheng S,Ni B,Fang D,Song J
Fri Feb 05 00:00:00 EST 2016
B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia.
The Journal of biological chemistry
Imoto N,Hayakawa F,Kurahashi S,Morishita T,Kojima Y,Yasuda T,Sugimoto K,Tsuzuki S,Naoe T,Kiyoi H
Fri Feb 26 00:00:00 EST 2016
CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells.
Nature communications
Cho JH,Kim HO,Ju YJ,Kye YC,Lee GW,Lee SW,Yun CH,Bottini N,Webster K,Goodnow CC,Surh CD,King C,Sprent J
Mon Nov 14 00:00:00 EST 2016
EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Scientific reports
Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G
217-17 was used in Tissue/organ culture to identify EphrinB2 as an essential regulator of adult haematopoiesis but not generation of endothelial cells.
Thu Jun 02 00:00:00 EDT 2016
Thymic exosomes promote the final maturation of thymocytes.
Scientific reports
Lundberg V,Berglund M,Skogberg G,Lindgren S,Lundqvist C,Gudmundsdottir J,Thörn K,Telemo E,Ekwall O
Tue Nov 08 00:00:00 EST 2016
CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation.
Nature communications
Cao W,Guo J,Wen X,Miao L,Lin F,Xu G,Ma R,Yin S,Hui Z,Chen T,Guo S,Chen W,Huang Y,Liu Y,Wang J,Wei L,Wang L
Mon May 23 00:00:00 EDT 2016
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.
Nature communications
Gu Z,Churchman M,Roberts K,Li Y,Liu Y,Harvey RC,McCastlain K,Reshmi SC,Payne-Turner D,Iacobucci I,Shao Y,Chen IM,Valentine M,Pei D,Mungall KL,Mungall AJ,Ma Y,Moore R,Marra M,Stonerock E,Gastier-Foster JM,Devidas M,Dai Y,Wood B,Borowitz M,Larsen EE,Maloney K,Mattano LA,Angiolillo A,Salzer WL,Burke MJ,Gianni F,Spinelli O,Radich JP,Minden MD,Moorman AV,Patel B,Fielding AK,Rowe JM,Luger SM,Bhatia R,Aldoss I,Forman SJ,Kohlschmidt J,Mrózek K,Marcucci G,Bloomfield CD,Stock W,Kornblau S,Kantarjian HM,Konopleva M,Paietta E,Willman CL,Loh ML,Hunger SP,Mullighan CG
Tue Nov 08 00:00:00 EST 2016
Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche.
Nature communications
Hu X,Garcia M,Weng L,Jung X,Murakami JL,Kumar B,Warden CD,Todorov I,Chen CC
Mon Oct 10 00:00:00 EDT 2016
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
Nature
Chen Z,Shojaee S,Buchner M,Geng H,Lee JW,Klemm L,Titz B,Graeber TG,Park E,Tan YX,Satterthwaite A,Paietta E,Hunger SP,Willman CL,Melnick A,Loh ML,Jung JU,Coligan JE,Bolland S,Mak TW,Limnander A,Jumaa H,Reth M,Weiss A,Lowell CA,Müschen M
Thu May 21 00:00:00 EDT 2015
A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis.
Blood
Jackson JT,Nasa C,Shi W,Huntington ND,Bogue CW,Alexander WS,McCormack MP
Thu Jan 29 00:00:00 EST 2015
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.
Blood
Van der Meulen J,Sanghvi V,Mavrakis K,Durinck K,Fang F,Matthijssens F,Rondou P,Rosen M,Pieters T,Vandenberghe P,Delabesse E,Lammens T,De Moerloose B,Menten B,Van Roy N,Verhasselt B,Poppe B,Benoit Y,Taghon T,Melnick AM,Speleman F,Wendel HG,Van Vlierberghe P
Thu Jan 01 00:00:00 EST 2015
Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.
The Journal of clinical investigation
Duque-Afonso J,Feng J,Scherer F,Lin CH,Wong SH,Wang Z,Iwasaki M,Cleary ML
Tue Sep 01 00:00:00 EDT 2015
Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors.
The Journal of experimental medicine
Ungerbäck J,Åhsberg J,Strid T,Somasundaram R,Sigvardsson M
Mon Jun 29 00:00:00 EDT 2015
The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.
The Journal of experimental medicine
Yu Y,Wang C,Clare S,Wang J,Lee SC,Brandt C,Burke S,Lu L,He D,Jenkins NA,Copeland NG,Dougan G,Liu P
Mon Jun 01 00:00:00 EDT 2015
DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3.
The Journal of experimental medicine
Thompson BJ,Bhansali R,Diebold L,Cook DE,Stolzenburg L,Casagrande AS,Besson T,Leblond B,Désiré L,Malinge S,Crispino JD
Mon Jun 01 00:00:00 EDT 2015
Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes.
The EMBO journal
Preston GC,Sinclair LV,Kaskar A,Hukelmann JL,Navarro MN,Ferrero I,MacDonald HR,Cowling VH,Cantrell DA
Tue Aug 04 00:00:00 EDT 2015
IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice.
Proceedings of the National Academy of Sciences of the United States of America
Schmaler M,Broggi MA,Lagarde N,Stöcklin BF,King CG,Finke D,Rossi SW
Tue Oct 27 00:00:00 EDT 2015
Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Godec J,Cowley GS,Barnitz RA,Alkan O,Root DE,Sharpe AH,Haining WN
Tue Jan 13 00:00:00 EST 2015
Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
Willinger T,Staron M,Ferguson SM,De Camilli P,Flavell RA
Tue Apr 07 00:00:00 EDT 2015
T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses.
Proceedings of the National Academy of Sciences of the United States of America
Baumann C,Bonilla WV,Fröhlich A,Helmstetter C,Peine M,Hegazy AN,Pinschewer DD,Löhning M
Tue Mar 31 00:00:00 EDT 2015
Spred1, a Suppressor of the Ras-ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells.
Journal of immunology (Baltimore, Md. : 1950)
Suzuki M,Morita R,Hirata Y,Shichita T,Yoshimura A
Sat Aug 01 00:00:00 EDT 2015
Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK.
Journal of immunology (Baltimore, Md. : 1950)
Ebel ME,Awe O,Kaplan MH,Kansas GS
Mon Jun 15 00:00:00 EDT 2015
Responsiveness of Developing T Cells to IL-7 Signals Is Sustained by miR-17∼92.
Journal of immunology (Baltimore, Md. : 1950)
Regelin M,Blume J,Pommerencke J,Vakilzadeh R,Witzlau K,Łyszkiewicz M,Ziętara N,Saran N,Schambach A,Krueger A
Sun Nov 15 00:00:00 EST 2015
c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway.
Journal of immunology (Baltimore, Md. : 1950)
He MX,He YW
Wed Apr 01 00:00:00 EDT 2015
Calcium-Modulating Cyclophilin Ligand Is Essential for the Survival of Activated T Cells and for Adaptive Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Chan SL,Lindquist LD,Hansen MJ,Girtman MA,Pease LR,Bram RJ
Tue Dec 15 00:00:00 EST 2015
A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice.
Journal of immunology (Baltimore, Md. : 1950)
Nakamura M,Shibata K,Hatano S,Sato T,Ohkawa Y,Yamada H,Ikuta K,Yoshikai Y
Thu Jan 01 00:00:00 EST 2015
CD8(+)NKT-like cells regulate the immune response by killing antigen-bearing DCs.
Scientific reports
Wang C,Liu X,Li Z,Chai Y,Jiang Y,Wang Q,Ji Y,Zhu Z,Wan Y,Yuan Z,Chang Z,Zhang M
Tue Sep 15 00:00:00 EDT 2015
KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.
Nature communications
Kamimura D,Katsunuma K,Arima Y,Atsumi T,Jiang JJ,Bando H,Meng J,Sabharwal L,Stofkova A,Nishikawa N,Suzuki H,Ogura H,Ueda N,Tsuruoka M,Harada M,Kobayashi J,Hasegawa T,Yoshida H,Koseki H,Miura I,Wakana S,Nishida K,Kitamura H,Fukada T,Hirano T,Murakami M
Wed Jun 17 00:00:00 EDT 2015
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.
Nature communications
Goossens S,Radaelli E,Blanchet O,Durinck K,Van der Meulen J,Peirs S,Taghon T,Tremblay CS,Costa M,Farhang Ghahremani M,De Medts J,Bartunkova S,Haigh K,Schwab C,Farla N,Pieters T,Matthijssens F,Van Roy N,Best JA,Deswarte K,Bogaert P,Carmichael C,Rickard A,Suryani S,Bracken LS,Alserihi R,Canté-Barrett K,Haenebalcke L,Clappier E,Rondou P,Slowicka K,Huylebroeck D,Goldrath AW,Janzen V,McCormack MP,Lock RB,Curtis DJ,Harrison C,Berx G,Speleman F,Meijerink JP,Soulier J,Van Vlierberghe P,Haigh JJ
Wed Jan 07 00:00:00 EST 2015
In vivo discovery of immunotherapy targets in the tumour microenvironment.
Nature
Zhou P,Shaffer DR,Alvarez Arias DA,Nakazaki Y,Pos W,Torres AJ,Cremasco V,Dougan SK,Cowley GS,Elpek K,Brogdon J,Lamb J,Turley SJ,Ploegh HL,Root DE,Love JC,Dranoff G,Hacohen N,Cantor H,Wucherpfennig KW
Thu Feb 06 00:00:00 EST 2014
Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.
Cell
Klose CSN,Flach M,Möhle L,Rogell L,Hoyler T,Ebert K,Fabiunke C,Pfeifer D,Sexl V,Fonseca-Pereira D,Domingues RG,Veiga-Fernandes H,Arnold SJ,Busslinger M,Dunay IR,Tanriver Y,Diefenbach A
Thu Apr 10 00:00:00 EDT 2014
A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy.
Blood
Philip B,Kokalaki E,Mekkaoui L,Thomas S,Straathof K,Flutter B,Marin V,Marafioti T,Chakraverty R,Linch D,Quezada SA,Peggs KS,Pule M
Thu Aug 21 00:00:00 EDT 2014
JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.
Blood
Degryse S,de Bock CE,Cox L,Demeyer S,Gielen O,Mentens N,Jacobs K,Geerdens E,Gianfelici V,Hulselmans G,Fiers M,Aerts S,Meijerink JP,Tousseyn T,Cools J
Thu Nov 13 00:00:00 EST 2014
Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression.
The Journal of clinical investigation
Sungalee S,Mamessier E,Morgado E,Grégoire E,Brohawn PZ,Morehouse CA,Jouve N,Monvoisin C,Menard C,Debroas G,Faroudi M,Mechin V,Navarro JM,Drevet C,Eberle FC,Chasson L,Baudimont F,Mancini SJ,Tellier J,Picquenot JM,Kelly R,Vineis P,Ruminy P,Chetaille B,Jaffe ES,Schiff C,Hardwigsen J,Tice DA,Higgs BW,Tarte K,Nadel B,Roulland S
Mon Dec 01 00:00:00 EST 2014
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.
The Journal of clinical investigation
Bestas B,Moreno PM,Blomberg KE,Mohammad DK,Saleh AF,Sutlu T,Nordin JZ,Guterstam P,Gustafsson MO,Kharazi S,Piątosa B,Roberts TC,Behlke MA,Wood MJ,Gait MJ,Lundin KE,El Andaloussi S,Månsson R,Berglöf A,Wengel J,Smith CI
Mon Sep 01 00:00:00 EDT 2014
Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential.
The Journal of experimental medicine
Treanor LM,Zhou S,Janke L,Churchman ML,Ma Z,Lu T,Chen SC,Mullighan CG,Sorrentino BP
Mon Apr 07 00:00:00 EDT 2014
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
The Journal of experimental medicine
Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ
Mon Apr 07 00:00:00 EDT 2014
CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.
The Journal of experimental medicine
Longman RS,Diehl GE,Victorio DA,Huh JR,Galan C,Miraldi ER,Swaminath A,Bonneau R,Scherl EJ,Littman DR
Mon Jul 28 00:00:00 EDT 2014
Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.
The Journal of experimental medicine
Järås M,Miller PG,Chu LP,Puram RV,Fink EC,Schneider RK,Al-Shahrour F,Peña P,Breyfogle LJ,Hartwell KA,McConkey ME,Cowley GS,Root DE,Kharas MG,Mullally A,Ebert BL
Mon Apr 07 00:00:00 EDT 2014
Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.
The Journal of experimental medicine
Kumar L,Chou J,Yee CS,Borzutzky A,Vollmann EH,von Andrian UH,Park SY,Hollander G,Manis JP,Poliani PL,Geha RS
Mon May 05 00:00:00 EDT 2014
Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals.
Proceedings of the National Academy of Sciences of the United States of America
Zarin P,Wong GW,Mohtashami M,Wiest DL,Zúñiga-Pflücker JC
Tue Apr 15 00:00:00 EDT 2014
Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development.
Proceedings of the National Academy of Sciences of the United States of America
Kobayashi M,Shelley WC,Seo W,Vemula S,Lin Y,Liu Y,Kapur R,Taniuchi I,Yoshimoto M
Tue Aug 19 00:00:00 EDT 2014
NF-κB signaling mediates homeostatic maturation of new T cells.
Proceedings of the National Academy of Sciences of the United States of America
Silva A,Cornish G,Ley SC,Seddon B
Tue Mar 04 00:00:00 EST 2014
Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Rei M,Gonçalves-Sousa N,Lança T,Thompson RG,Mensurado S,Balkwill FR,Kulbe H,Pennington DJ,Silva-Santos B
Tue Aug 26 00:00:00 EDT 2014
Basal NF-κB controls IL-7 responsiveness of quiescent naïve T cells.
Proceedings of the National Academy of Sciences of the United States of America
Miller ML,Mashayekhi M,Chen L,Zhou P,Liu X,Michelotti M,Tramontini Gunn N,Powers S,Zhu X,Evaristo C,Alegre ML,Molinero LL
Tue May 20 00:00:00 EDT 2014
PDK1 regulates B cell differentiation and homeostasis.
Proceedings of the National Academy of Sciences of the United States of America
Baracho GV,Cato MH,Zhu Z,Jaren OR,Hobeika E,Reth M,Rickert RC
Tue Jul 01 00:00:00 EDT 2014
Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America
Kharabi Masouleh B,Geng H,Hurtz C,Chan LN,Logan AC,Chang MS,Huang C,Swaminathan S,Sun H,Paietta E,Melnick AM,Koeffler P,Müschen M
Tue May 27 00:00:00 EDT 2014
Identification of multipotent progenitors that emerge prior to hematopoietic stem cells in embryonic development.
Stem cell reports
Inlay MA,Serwold T,Mosley A,Fathman JW,Dimov IK,Seita J,Weissman IL
217-17 was used in Sample Preparation (FC/FACS) to develop a single-cell multipotency assay which can be used to identify when and where clonal multilineage potential arises during embryogenesis.
Tue Apr 08 00:00:00 EDT 2014
Allelic exclusion of IgH through inhibition of E2A in a VDJ recombination complex.
Journal of immunology (Baltimore, Md. : 1950)
Hauser J,Grundström C,Grundström T
Sat Mar 01 00:00:00 EST 2014
IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals.
Journal of immunology (Baltimore, Md. : 1950)
Walsh MC,Pearce EL,Cejas PJ,Lee J,Wang LS,Choi Y
Wed Oct 15 00:00:00 EDT 2014
Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis.
Journal of immunology (Baltimore, Md. : 1950)
Johnson TS,Terrell CE,Millen SH,Katz JD,Hildeman DA,Jordan MB
Wed Jan 01 00:00:00 EST 2014
Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y
Sun Jun 15 00:00:00 EDT 2014
Eliminating encephalitogenic T cells without undermining protective immunity.
Journal of immunology (Baltimore, Md. : 1950)
McNally JP,Elfers EE,Terrell CE,Grunblatt E,Hildeman DA,Jordan MB,Katz JD
Wed Jan 01 00:00:00 EST 2014
CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling.
Cell death & disease
Ho KC,Chiang YJ,Lai AC,Liao NS,Chang YJ,Yang-Yen HF,Yen JJ
Thu Nov 13 00:00:00 EST 2014
Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity.
Immunity
Castagnaro L,Lenti E,Maruzzelli S,Spinardi L,Migliori E,Farinello D,Sitia G,Harrelson Z,Evans SM,Guidotti LG,Harvey RP,Brendolan A
Thu Apr 18 00:00:00 EDT 2013
Runx1 is essential at two stages of early murine B-cell development.
Blood
Niebuhr B,Kriebitzsch N,Fischer M,Behrens K,Günther T,Alawi M,Bergholz U,Müller U,Roscher S,Ziegler M,Buchholz F,Grundhoff A,Stocking C
Thu Jul 18 00:00:00 EDT 2013
Differential effects of γc cytokines on postselection differentiation of CD8 thymocytes.
Blood
Rafei M,Rouette A,Brochu S,Vanegas JR,Perreault C
Thu Jan 03 00:00:00 EST 2013
Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.
Blood
Lee SC,Phipson B,Hyland CD,Leong HS,Allan RS,Lun A,Hilton DJ,Nutt SL,Blewitt ME,Smyth GK,Alexander WS,Majewski IJ
Thu Oct 10 00:00:00 EDT 2013
Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength.
Journal of immunology (Baltimore, Md. : 1950)
Knudson KM,Hamilton SE,Daniels MA,Jameson SC,Teixeiro E
Sun Dec 15 00:00:00 EST 2013
Unique features of naive CD8+ T cell activation by IL-2.
Journal of immunology (Baltimore, Md. : 1950)
Cho JH,Kim HO,Kim KS,Yang DH,Surh CD,Sprent J
Sun Dec 01 00:00:00 EST 2013
Transcriptional regulation of IL-15 expression during hematopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Colpitts SL,Stonier SW,Stoklasek TA,Root SH,Aguila HL,Schluns KS,Lefrançois L
Sun Sep 15 00:00:00 EDT 2013
Selective activation of antigen-experienced T cells by anti-CD3 constrained on nanoparticles.
Journal of immunology (Baltimore, Md. : 1950)
Lo YC,Edidin MA,Powell JD
Fri Nov 15 00:00:00 EST 2013
CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool.
Journal of immunology (Baltimore, Md. : 1950)
Peperzak V,Veraar EA,Xiao Y,Babala N,Thiadens K,Brugmans M,Borst J
Sun Sep 15 00:00:00 EDT 2013
Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development.
Journal of immunology (Baltimore, Md. : 1950)
Li J,Zhao Z,Carter C,Ehrlich LI,Bedford MT,Richie ER
Tue Jan 15 00:00:00 EST 2013
Inflammation-mediated notch signaling skews fanconi anemia hematopoietic stem cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Du W,Amarachintha S,Sipple J,Schick J,Steinbrecher K,Pang Q
Sun Sep 01 00:00:00 EDT 2013
Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Han S,Jeong AL,Lee S,Park JS,Kim KD,Choi I,Yoon SR,Lee MS,Lim JS,Han SH,Yoon DY,Yang Y
Wed May 01 00:00:00 EDT 2013
Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.
The Journal of biological chemistry
Suzuki J,Fujii T,Imao T,Ishihara K,Kuba H,Nagata S
Fri May 10 00:00:00 EDT 2013
Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.
Cell
Hu J,Hwang SS,Liesa M,Gan B,Sahin E,Jaskelioff M,Ding Z,Ying H,Boutin AT,Zhang H,Johnson S,Ivanova E,Kost-Alimova M,Protopopov A,Wang YA,Shirihai OS,Chin L,DePinho RA
Fri Feb 17 00:00:00 EST 2012
Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity.
Cell
Zhang JA,Mortazavi A,Williams BA,Wold BJ,Rothenberg EV
Fri Apr 13 00:00:00 EDT 2012
HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.
Blood
Wong GW,Knowles GC,Mak TW,Ferrando AA,Zúñiga-Pflücker JC
Thu Aug 16 00:00:00 EDT 2012
Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo.
Blood
Tang Y,Peitzsch C,Charoudeh HN,Cheng M,Chaves P,Jacobsen SE,Sitnicka E
Thu Jul 05 00:00:00 EDT 2012
Inhibition of the mTORC2 and chaperone pathways to treat leukemia.
Blood
Zhang F,Lazorchak AS,Liu D,Chen F,Su B
Thu Jun 21 00:00:00 EDT 2012
Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors.
Blood
Cooper CL,Hardy RR,Reth M,Desiderio S
Thu Jun 07 00:00:00 EDT 2012
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.
Blood
Nishida C,Kusubata K,Tashiro Y,Gritli I,Sato A,Ohki-Koizumi M,Morita Y,Nagano M,Sakamoto T,Koshikawa N,Kuchimaru T,Kizaka-Kondoh S,Seiki M,Nakauchi H,Heissig B,Hattori K
Thu Jun 07 00:00:00 EDT 2012
Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.
Blood
Chang KH,Sanchez-Aguilera A,Shen S,Sengupta A,Madhu MN,Ficker AM,Dunn SK,Kuenzi AM,Arnett JL,Santho RA,Agirre X,Perentesis JP,Deininger MW,Zheng Y,Bustelo XR,Williams DA,Cancelas JA
Thu Jul 26 00:00:00 EDT 2012
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.
The Journal of experimental medicine
Austin WR,Armijo AL,Campbell DO,Singh AS,Hsieh T,Nathanson D,Herschman HR,Phelps ME,Witte ON,Czernin J,Radu CG
Mon Nov 19 00:00:00 EST 2012
Bcl11a is essential for lymphoid development and negatively regulates p53.
The Journal of experimental medicine
Yu Y,Wang J,Khaled W,Burke S,Li P,Chen X,Yang W,Jenkins NA,Copeland NG,Zhang S,Liu P
Mon Dec 17 00:00:00 EST 2012
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
The Journal of experimental medicine
Cherrier M,Sawa S,Eberl G
Mon Apr 09 00:00:00 EDT 2012
Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice.
Journal of autoimmunity
Tischner D,Gaggl I,Peschel I,Kaufmann M,Tuzlak S,Drach M,Thuille N,Villunger A,Jan Wiegers G
Wed Feb 01 00:00:00 EST 2012
Coreceptor gene imprinting governs thymocyte lineage fate.
The EMBO journal
Adoro S,McCaughtry T,Erman B,Alag A,Van Laethem F,Park JH,Tai X,Kimura M,Wang L,Grinberg A,Kubo M,Bosselut R,Love P,Singer A
Wed Jan 18 00:00:00 EST 2012
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Penaranda C,Kuswanto W,Hofmann J,Kenefeck R,Narendran P,Walker LS,Bluestone JA,Abbas AK,Dooms H
Tue Jul 31 00:00:00 EDT 2012
Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Zandi S,Ahsberg J,Tsapogas P,Stjernberg J,Qian H,Sigvardsson M
Tue Sep 25 00:00:00 EDT 2012
Purinergic P2X7 receptor drives T cell lineage choice and shapes peripheral γδ cells.
Journal of immunology (Baltimore, Md. : 1950)
Frascoli M,Marcandalli J,Schenk U,Grassi F
Sun Jul 01 00:00:00 EDT 2012
RGS16 attenuates pulmonary Th2/Th17 inflammatory responses.
Journal of immunology (Baltimore, Md. : 1950)
Shankar SP,Wilson MS,DiVietro JA,Mentink-Kane MM,Xie Z,Wynn TA,Druey KM
Fri Jun 15 00:00:00 EDT 2012
Foxp3 expression is required for the induction of therapeutic tissue tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Regateiro FS,Chen Y,Kendal AR,Hilbrands R,Adams E,Cobbold SP,Ma J,Andersen KG,Betz AG,Zhang M,Madhiwalla S,Roberts B,Waldmann H,Nolan KF,Howie D
Mon Oct 15 00:00:00 EDT 2012
Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Xu LS,Sokalski KM,Hotke K,Christie DA,Zarnett O,Piskorz J,Thillainadesan G,Torchia J,DeKoter RP
Mon Oct 01 00:00:00 EDT 2012
Development of memory CD8+ T cells and their recall responses during blood-stage infection with Plasmodium berghei ANKA.
Journal of immunology (Baltimore, Md. : 1950)
Miyakoda M,Kimura D,Honma K,Kimura K,Yuda M,Yui K
Thu Nov 01 00:00:00 EDT 2012
Negative regulation of NKG2D expression by IL-4 in memory CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Ventre E,Brinza L,Schicklin S,Mafille J,Coupet CA,Marçais A,Djebali S,Jubin V,Walzer T,Marvel J
Mon Oct 01 00:00:00 EDT 2012
The SWI/SNF-like BAF complex is essential for early B cell development.
Journal of immunology (Baltimore, Md. : 1950)
Choi J,Ko M,Jeon S,Jeon Y,Park K,Lee C,Lee H,Seong RH
Sun Apr 15 00:00:00 EDT 2012
Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Dervovic DD,Ciofani M,Kianizad K,Zúñiga-Pflücker JC
Mon Oct 01 00:00:00 EDT 2012
The development of colitogenic CD4(+) T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis.
Journal of immunology (Baltimore, Md. : 1950)
Yamaji O,Nagaishi T,Totsuka T,Onizawa M,Suzuki M,Tsuge N,Hasegawa A,Okamoto R,Tsuchiya K,Nakamura T,Arase H,Kanai T,Watanabe M
Thu Mar 15 00:00:00 EDT 2012
A combination of local inflammation and central memory T cells potentiates immunotherapy in the skin.
Journal of immunology (Baltimore, Md. : 1950)
Fiorenza S,Kenna TJ,Comerford I,McColl S,Steptoe RJ,Leggatt GR,Frazer IH
Sat Dec 15 00:00:00 EST 2012
Role of recycling, Mindbomb1 association, and exclusion from lipid rafts of δ-like 4 for effective Notch signaling to drive T cell development.
Journal of immunology (Baltimore, Md. : 1950)
Shah DK,Mohtashami M,Zúñiga-Pflücker JC
Sat Dec 15 00:00:00 EST 2012
Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Haque R,Lei F,Xiong X,Bian Y,Zhao B,Wu Y,Song J
Wed Aug 01 00:00:00 EDT 2012
Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells.
The Biochemical journal
Navarro MN,Sinclair LV,Feijoo-Carnero C,Clarke R,Matthews SA,Cantrell DA
Thu Mar 15 00:00:00 EDT 2012
Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.
PloS one
Caserta S,Nausch N,Sawtell A,Drummond R,Barr T,Macdonald AS,Mutapi F,Zamoyska R
Thu Aug 23 00:00:00 EDT 2012
Exogenous amino acids are essential for interleukin-7 induced CD8 T cell growth. [corrected].
PloS one
Pearson C,Silva A,Seddon B
Mon Nov 19 00:00:00 EST 2012
Dual anti-OX40/IL-2 therapy augments tumor immunotherapy via IL-2R-mediated regulation of OX40 expression.
PloS one
Redmond WL,Triplett T,Floyd K,Weinberg AD
Tue Aug 21 00:00:00 EDT 2012
Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms.
PloS one
Lucas S,Taront S,Magnan C,Fauconnier L,Delacre M,Macia L,Delanoye A,Verwaerde C,Spriet C,Saule P,Goormachtigh G,Héliot L,Ktorza A,Movassat J,Polakowska R,Auriault C,Poulain-Godefroy O,Di Santo J,Froguel P,Wolowczuk I
Tue Nov 27 00:00:00 EST 2012
Exposure of a distinct PDCA-1+ (CD317) B cell population to agonistic anti-4-1BB (CD137) inhibits T and B cell responses both in vitro and in vivo.
PloS one
Vinay DS,Lee SJ,Kim CH,Oh HS,Kwon BS
Mon May 13 00:00:00 EDT 2013
JunD/AP-1-mediated gene expression promotes lymphocyte growth dependent on interleukin-7 signal transduction.
PloS one
Ruppert SM,Chehtane M,Zhang G,Hu H,Li X,Khaled AR
Mon Aug 27 00:00:00 EDT 2012
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition.
Nature
Duy C,Hurtz C,Shojaee S,Cerchietti L,Geng H,Swaminathan S,Klemm L,Kweon SM,Nahar R,Braig M,Park E,Kim YM,Hofmann WK,Herzog S,Jumaa H,Koeffler HP,Yu JJ,Heisterkamp N,Graeber TG,Wu H,Ye BH,Melnick A,Müschen M
Thu May 19 00:00:00 EDT 2011
Skint-1 identifies a common molecular mechanism for the development of interferon-γ-secreting versus interleukin-17-secreting γδ T cells.
Immunity
Turchinovich G,Hayday AC
Fri Jul 22 00:00:00 EDT 2011
CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut.
Immunity
Sonnenberg GF,Monticelli LA,Elloso MM,Fouser LA,Artis D
Fri Jan 28 00:00:00 EST 2011
A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity.
Immunity
Li Q,Rao RR,Araki K,Pollizzi K,Odunsi K,Powell JD,Shrikant PA
Fri Apr 22 00:00:00 EDT 2011
Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia.
Blood
Janikashvili N,LaCasse CJ,Larmonier C,Trad M,Herrell A,Bustamante S,Bonnotte B,Har-Noy M,Larmonier N,Katsanis E
Thu Feb 03 00:00:00 EST 2011
Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors.
Blood
Heinonen KM,Vanegas JR,Brochu S,Shan J,Vainio SJ,Perreault C
Thu Nov 10 00:00:00 EST 2011
IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors.
Blood
Tsapogas P,Zandi S,Åhsberg J,Zetterblad J,Welinder E,Jönsson JI,Månsson R,Qian H,Sigvardsson M
Thu Aug 04 00:00:00 EDT 2011
Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.
Blood
Treanor LM,Volanakis EJ,Zhou S,Lu T,Sherr CJ,Sorrentino BP
Thu May 19 00:00:00 EDT 2011
IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1.
Blood
Saba I,Kosan C,Vassen L,Möröy T
Thu Mar 24 00:00:00 EDT 2011
Development of thymic NK cells from double negative 1 thymocyte precursors.
Blood
Vargas CL,Poursine-Laurent J,Yang L,Yokoyama WM
Thu Sep 29 00:00:00 EDT 2011
In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors.
Blood
Richie Ehrlich LI,Serwold T,Weissman IL
Thu Mar 03 00:00:00 EST 2011
Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC.
Blood
Nahar R,Ramezani-Rad P,Mossner M,Duy C,Cerchietti L,Geng H,Dovat S,Jumaa H,Ye BH,Melnick A,Müschen M
Thu Oct 13 00:00:00 EDT 2011
Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice.
Blood
Li L,Zhang L,Fan J,Greenberg K,Desiderio S,Rassool FV,Small D
Thu Mar 17 00:00:00 EDT 2011
Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans.
The Journal of clinical investigation
Lv H,Havari E,Pinto S,Gottumukkala RV,Cornivelli L,Raddassi K,Matsui T,Rosenzweig A,Bronson RT,Smith R,Fletcher AL,Turley SJ,Wucherpfennig K,Kyewski B,Lipes MA
Fri Apr 01 00:00:00 EDT 2011
Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors.
Nucleic acids research
Bandaranayake AD,Correnti C,Ryu BY,Brault M,Strong RK,Rawlings DJ
Tue Nov 01 00:00:00 EDT 2011
Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.
The Journal of experimental medicine
Heltemes-Harris LM,Willette MJ,Ramsey LB,Qiu YH,Neeley ES,Zhang N,Thomas DA,Koeuth T,Baechler EC,Kornblau SM,Farrar MA
Mon Jun 06 00:00:00 EDT 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
Mon Apr 11 00:00:00 EDT 2011
NKAP is required for T cell maturation and acquisition of functional competency.
The Journal of experimental medicine
Hsu FC,Pajerowski AG,Nelson-Holte M,Sundsbak R,Shapiro VS
Mon Jun 06 00:00:00 EDT 2011
KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells.
The Journal of experimental medicine
Lai D,Zhu J,Wang T,Hu-Li J,Terabe M,Berzofsky JA,Clayberger C,Krensky AM
Mon May 09 00:00:00 EDT 2011
Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus.
Proceedings of the National Academy of Sciences of the United States of America
Calderón L,Boehm T
Tue May 03 00:00:00 EDT 2011
Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells.
Immunology and cell biology
Palmer MJ,Mahajan VS,Chen J,Irvine DJ,Lauffenburger DA
Fri Jul 01 00:00:00 EDT 2011
T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950)
Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z
Thu Dec 01 00:00:00 EST 2011
Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy.
Journal of immunology (Baltimore, Md. : 1950)
Jia W,He YW
Sun May 01 00:00:00 EDT 2011
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Penaranda C,Tang Q,Bluestone JA
Mon Aug 15 00:00:00 EDT 2011
Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.
Journal of immunology (Baltimore, Md. : 1950)
Guikema JE,Gerstein RM,Linehan EK,Cloherty EK,Evan-Browning E,Tsuchimoto D,Nakabeppu Y,Schrader CE
Tue Feb 15 00:00:00 EST 2011
In vivo administration of the recombinant IL-7/hepatocyte growth factor β hybrid cytokine efficiently restores thymopoiesis and naive T cell generation in lethally irradiated mice after syngeneic bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950)
Jin J,Goldschneider I,Lai L
Tue Feb 15 00:00:00 EST 2011
In vivo administration of the recombinant IL-7/hepatocyte growth factor β hybrid cytokine efficiently restores thymopoiesis and naive T cell generation in lethally irradiated mice after syngeneic bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950)
Jin J,Goldschneider I,Lai L
Tue Feb 15 00:00:00 EST 2011
A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection.
Journal of immunology (Baltimore, Md. : 1950)
Verbist KC,Cole CJ,Field MB,Klonowski KD
Sat Jan 01 00:00:00 EST 2011
ADAM10 overexpression shifts lympho- and myelopoiesis by dysregulating site 2/site 3 cleavage products of Notch.
Journal of immunology (Baltimore, Md. : 1950)
Gibb DR,Saleem SJ,Kang DJ,Subler MA,Conrad DH
Fri Apr 01 00:00:00 EDT 2011
A role for autophagic protein beclin 1 early in lymphocyte development.
Journal of immunology (Baltimore, Md. : 1950)
Arsov I,Adebayo A,Kucerova-Levisohn M,Haye J,MacNeil M,Papavasiliou FN,Yue Z,Ortiz BD
Tue Feb 15 00:00:00 EST 2011
Activated NKT cells and NK cells render T cells resistant to myeloid-derived suppressor cells and result in an effective adoptive cellular therapy against breast cancer in the FVBN202 transgenic mouse.
Journal of immunology (Baltimore, Md. : 1950)
Kmieciak M,Basu D,Payne KK,Toor A,Yacoub A,Wang XY,Smith L,Bear HD,Manjili MH
Fri Jul 15 00:00:00 EDT 2011
The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.
Journal of immunology (Baltimore, Md. : 1950)
McLeod IX,Zhou X,Li QJ,Wang F,He YW
Tue Nov 15 00:00:00 EST 2011
Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2-M3.
Journal of immunology (Baltimore, Md. : 1950)
Cho H,Choi HJ,Xu H,Felio K,Wang CR
Sat Jan 01 00:00:00 EST 2011
Functional CD8 T cell memory responding to persistent latent infection is maintained for life.
Journal of immunology (Baltimore, Md. : 1950)
Lang A,Nikolich-Zugich J
Sat Oct 01 00:00:00 EDT 2011
Ex vivo expansion of tumor-reactive T cells by means of bryostatin 1/ionomycin and the common gamma chain cytokines formulation.
Journal of visualized experiments : JoVE
Kmieciak M,Toor A,Graham L,Bear HD,Manjili MH
Fri Jan 14 00:00:00 EST 2011
Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes.
Cell death & disease
Dunkle A,Dzhagalov I,He YW
Thu Oct 06 00:00:00 EDT 2011
Co-administration of IL-1+IL-6+TNF-α with Mycobacterium tuberculosis infected macrophages vaccine induces better protective T cell memory than BCG.
PloS one
Singh V,Jain S,Gowthaman U,Parihar P,Gupta P,Gupta UD,Agrewala JN
Wed Jan 19 00:00:00 EST 2011
Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3.
The Journal of biological chemistry
Liu Z,Yang A,Wang Z,Bunting KD,Davuluri G,Green MR,Devireddy LR
Fri Jun 10 00:00:00 EDT 2011
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.
PloS one
Eto D,Lao C,DiToro D,Barnett B,Escobar TC,Kageyama R,Yusuf I,Crotty S
Mon Mar 14 00:00:00 EDT 2011
Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.
PloS one
Siegert S,Huang HY,Yang CY,Scarpellino L,Carrie L,Essex S,Nelson PJ,Heikenwalder M,Acha-Orbea H,Buckley CD,Marsland BJ,Zehn D,Luther SA
Mon Mar 26 00:00:00 EDT 2012
Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
Nature
Ji H,Ehrlich LI,Seita J,Murakami P,Doi A,Lindau P,Lee H,Aryee MJ,Irizarry RA,Kim K,Rossi DJ,Inlay MA,Serwold T,Karsunky H,Ho L,Daley GQ,Weissman IL,Feinberg AP
Thu Sep 16 00:00:00 EDT 2010
A reprogrammable mouse strain from gene-targeted embryonic stem cells.
Nature methods
Stadtfeld M,Maherali N,Borkent M,Hochedlinger K
Fri Jan 01 00:00:00 EST 2010
Single-gene transgenic mouse strains for reprogramming adult somatic cells.
Nature methods
Carey BW,Markoulaki S,Beard C,Hanna J,Jaenisch R
Fri Jan 01 00:00:00 EST 2010
Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes.
Immunity
Vonarbourg C,Mortha A,Bui VL,Hernandez PP,Kiss EA,Hoyler T,Flach M,Bengsch B,Thimme R,Hölscher C,Hönig M,Pannicke U,Schwarz K,Ware CF,Finke D,Diefenbach A
Wed Nov 24 00:00:00 EST 2010
The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.
Immunity
Rao RR,Li Q,Odunsi K,Shrikant PA
Fri Jan 29 00:00:00 EST 2010
Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation.
Immunity
Kosan C,Saba I,Godmann M,Herold S,Herkert B,Eilers M,Möröy T
Tue Dec 14 00:00:00 EST 2010
Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Valpha14-Jalpha18 TCRalpha gene.
Blood
Watarai H,Rybouchkin A,Hongo N,Nagata Y,Sakata S,Sekine E,Dashtsoodol N,Tashiro T,Fujii S,Shimizu K,Mori K,Masuda K,Kawamoto H,Koseki H,Taniguchi M
Thu Jan 14 00:00:00 EST 2010
Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.
Blood
Nozad Charoudeh H,Tang Y,Cheng M,Cilio CM,Jacobsen SE,Sitnicka E
Thu Jul 15 00:00:00 EDT 2010
Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.
Blood
Mansson R,Zandi S,Welinder E,Tsapogas P,Sakaguchi N,Bryder D,Sigvardsson M
Thu Apr 01 00:00:00 EDT 2010
HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice.
The Journal of clinical investigation
Khwaja SS,Liu H,Tong C,Jin F,Pear WS,van Deursen J,Bram RJ
Thu Jul 01 00:00:00 EDT 2010
Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells.
The Journal of clinical investigation
Watarai H,Fujii S,Yamada D,Rybouchkin A,Sakata S,Nagata Y,Iida-Kobayashi M,Sekine-Kondo E,Shimizu K,Shozaki Y,Sharif J,Matsuda M,Mochiduki S,Hasegawa T,Kitahara G,Endo TA,Toyoda T,Ohara O,Harigaya K,Koseki H,Taniguchi M
Thu Jul 01 00:00:00 EDT 2010
One naive T cell, multiple fates in CD8+ T cell differentiation.
The Journal of experimental medicine
Gerlach C,van Heijst JW,Swart E,Sie D,Armstrong N,Kerkhoven RM,Zehn D,Bevan MJ,Schepers K,Schumacher TN
Mon Jun 07 00:00:00 EDT 2010
BCL6 is critical for the development of a diverse primary B cell repertoire.
The Journal of experimental medicine
Duy C,Yu JJ,Nahar R,Swaminathan S,Kweon SM,Polo JM,Valls E,Klemm L,Shojaee S,Cerchietti L,Schuh W,Jäck HM,Hurtz C,Ramezani-Rad P,Herzog S,Jumaa H,Koeffler HP,de Alborán IM,Melnick AM,Ye BH,Müschen M
Mon Jun 07 00:00:00 EDT 2010
Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4.
The Journal of experimental medicine
Janas ML,Varano G,Gudmundsson K,Noda M,Nagasawa T,Turner M
Mon Jan 18 00:00:00 EST 2010
Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
Proceedings of the National Academy of Sciences of the United States of America
Rochman Y,Kashyap M,Robinson GW,Sakamoto K,Gomez-Rodriguez J,Wagner KU,Leonard WJ
Tue Nov 09 00:00:00 EST 2010
Dicer controls CD8+ T-cell activation, migration, and survival.
Proceedings of the National Academy of Sciences of the United States of America
Zhang N,Bevan MJ
Tue Dec 14 00:00:00 EST 2010
c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America
Rathinam C,Flavell RA
Tue May 04 00:00:00 EDT 2010
Activation of tolerogenic dendritic cells in the tumor draining lymph nodes by CD8+ T cells engineered to express CD40 ligand.
Journal of immunology (Baltimore, Md. : 1950)
Higham EM,Wittrup KD,Chen J
Thu Apr 01 00:00:00 EDT 2010
CD45 regulates migration, proliferation, and progression of double negative 1 thymocytes.
Journal of immunology (Baltimore, Md. : 1950)
Lai JC,Wlodarska M,Liu DJ,Abraham N,Johnson P
Sun Aug 15 00:00:00 EDT 2010
CD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors.
Journal of immunology (Baltimore, Md. : 1950)
Lio CW,Dodson LF,Deppong CM,Hsieh CS,Green JM
Tue Jun 01 00:00:00 EDT 2010
Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development.
Journal of immunology (Baltimore, Md. : 1950)
Chappaz S,Gärtner C,Rodewald HR,Finke D
Wed Sep 15 00:00:00 EDT 2010
PDCA expression by B lymphocytes reveals important functional attributes.
Journal of immunology (Baltimore, Md. : 1950)
Vinay DS,Kim CH,Chang KH,Kwon BS
Fri Jan 15 00:00:00 EST 2010
The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation.
Journal of immunology (Baltimore, Md. : 1950)
Peperzak V,Veraar EA,Keller AM,Xiao Y,Borst J
Wed Dec 01 00:00:00 EST 2010
A Flt3- and Ras-dependent pathway primes B cell development by inducing a state of IL-7 responsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Li LX,Goetz CA,Katerndahl CD,Sakaguchi N,Farrar MA
Mon Feb 15 00:00:00 EST 2010
"Default" generation of neonatal regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wang G,Miyahara Y,Guo Z,Khattar M,Stepkowski SM,Chen W
Thu Jul 01 00:00:00 EDT 2010
c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL.
Journal of immunology (Baltimore, Md. : 1950)
Yuan J,Crittenden RB,Bender TP
Mon Mar 15 00:00:00 EDT 2010
Hoxa9 regulates Flt3 in lymphohematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Gwin K,Frank E,Bossou A,Medina KL
Wed Dec 01 00:00:00 EST 2010
Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes.
Journal of immunology (Baltimore, Md. : 1950)
Mohtashami M,Shah DK,Nakase H,Kianizad K,Petrie HT,Zúñiga-Pflücker JC
Thu Jul 15 00:00:00 EDT 2010
Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow.
Journal of immunology (Baltimore, Md. : 1950)
Kojima H,Kobayashi A,Sakurai D,Kanno Y,Hase H,Takahashi R,Totsuka Y,Semenza GL,Sitkovsky MV,Kobata T
Fri Jan 01 00:00:00 EST 2010
A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway.
PloS one
Kovalovsky D,Pezzano M,Ortiz BD,Sant'Angelo DB
Wed Jan 13 00:00:00 EST 2010
Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication.
BMC genomics
Zetterblad J,Qian H,Zandi S,Månsson R,Lagergren A,Hansson F,Bryder D,Paulsson N,Sigvardsson M
Fri Feb 12 00:00:00 EST 2010
RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.
PloS one
Chae HD,Siefring JE,Hildeman DA,Gu Y,Williams DA
Fri Nov 12 00:00:00 EST 2010
Antigen-Experienced CD4lo T Cells Are Linked to Deficient Contraction of the Immune Response in Autoimmune Diabetes.
Autoimmune diseases
Linkes S,Fry C,Quinn A
Wed Sep 29 00:00:00 EDT 2010
Interleukin-7, a new cytokine targeting the mouse hypothalamic arcuate nucleus: role in body weight and food intake regulation.
PloS one
Macia L,Viltart O,Delacre M,Sachot C,Héliot L,Di Santo JP,Wolowczuk I
Thu Apr 01 00:00:00 EDT 2010
Interleukin-7-induced Stat-5 acts in synergy with Flt-3 signaling to stimulate expansion of hematopoietic progenitor cells.
The Journal of biological chemistry
Åhsberg J,Tsapogas P,Qian H,Zetterblad J,Zandi S,Månsson R,Jönsson JI,Sigvardsson M
Fri Nov 19 00:00:00 EST 2010
Direct cell reprogramming is a stochastic process amenable to acceleration.
Nature
Hanna J,Saha K,Pando B,van Zon J,Lengner CJ,Creyghton MP,van Oudenaarden A,Jaenisch R
Thu Dec 03 00:00:00 EST 2009
MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.
Cell
Sarrazin S,Mossadegh-Keller N,Fukao T,Aziz A,Mourcin F,Vanhille L,Kelly Modis L,Kastner P,Chan S,Duprez E,Otto C,Sieweke MH
Thu Jul 23 00:00:00 EDT 2009
Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.
Immunity
Lauritsen JP,Wong GW,Lee SY,Lefebvre JM,Ciofani M,Rhodes M,Kappes DJ,Zúñiga-Pflücker JC,Wiest DL
Fri Oct 16 00:00:00 EDT 2009
Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.
Nature genetics
Mullighan CG,Collins-Underwood JR,Phillips LA,Loudin MG,Liu W,Zhang J,Ma J,Coustan-Smith E,Harvey RC,Willman CL,Mikhail FM,Meyer J,Carroll AJ,Williams RT,Cheng J,Heerema NA,Basso G,Pession A,Pui CH,Raimondi SC,Hunger SP,Downing JR,Carroll WL,Rabin KR
Sun Nov 01 00:00:00 EDT 2009
Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c.
Nature immunology
Stehling-Sun S,Dade J,Nutt SL,DeKoter RP,Camargo FD
Sun Mar 01 00:00:00 EST 2009
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia.
Blood
Russell LJ,Capasso M,Vater I,Akasaka T,Bernard OA,Calasanz MJ,Chandrasekaran T,Chapiro E,Gesk S,Griffiths M,Guttery DS,Haferlach C,Harder L,Heidenreich O,Irving J,Kearney L,Nguyen-Khac F,Machado L,Minto L,Majid A,Moorman AV,Morrison H,Rand V,Strefford JC,Schwab C,Tönnies H,Dyer MJ,Siebert R,Harrison CJ
Thu Sep 24 00:00:00 EDT 2009
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.
Blood
Gekas C,Rhodes KE,Gereige LM,Helgadottir H,Ferrari R,Kurdistani SK,Montecino-Rodriguez E,Bassel-Duby R,Olson E,Krivtsov AV,Armstrong S,Orkin SH,Pellegrini M,Mikkola HK
Thu Apr 09 00:00:00 EDT 2009
Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants.
Blood
Opiela SJ,Koru-Sengul T,Adkins B
Thu May 28 00:00:00 EDT 2009
Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis.
Blood
Serwold T,Ehrlich LI,Weissman IL
Thu Jan 22 00:00:00 EST 2009
BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.
Blood
Nakayama J,Yamamoto M,Hayashi K,Satoh H,Bundo K,Kubo M,Goitsuka R,Farrar MA,Kitamura D
Thu Feb 12 00:00:00 EST 2009
An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans.
The Journal of clinical investigation
Hou Y,DeVoss J,Dao V,Kwek S,Simko JP,McNeel DG,Anderson MS,Fong L
Wed Jul 01 00:00:00 EDT 2009
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22.
The Journal of experimental medicine
Takatori H,Kanno Y,Watford WT,Tato CM,Weiss G,Ivanov II,Littman DR,O'Shea JJ
Fri Jan 16 00:00:00 EST 2009
Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas.
Proceedings of the National Academy of Sciences of the United States of America
Nepal RM,Tong L,Kolaj B,Edelmann W,Martin A
Tue Nov 03 00:00:00 EST 2009
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Ben-Sasson SZ,Hu-Li J,Quiel J,Cauchetaux S,Ratner M,Shapira I,Dinarello CA,Paul WE
Tue Apr 28 00:00:00 EDT 2009
A method for prolonged imaging of motile lymphocytes.
Immunology and cell biology
Day D,Pham K,Ludford-Menting MJ,Oliaro J,Izon D,Russell SM,Gu M
Sun Feb 01 00:00:00 EST 2009
c-Myb is required for pro-B cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Fahl SP,Crittenden RB,Allman D,Bender TP
Sun Nov 01 00:00:00 EDT 2009
IL-7 enhances thymic human T cell development in "human immune system" Rag2-/-IL-2Rgammac-/- mice without affecting peripheral T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
van Lent AU,Dontje W,Nagasawa M,Siamari R,Bakker AQ,Pouw SM,Maijoor KA,Weijer K,Cornelissen JJ,Blom B,Di Santo JP,Spits H,Legrand N
Tue Dec 15 00:00:00 EST 2009
The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression.
Journal of immunology (Baltimore, Md. : 1950)
Cen O,Ueda A,Guzman L,Jain J,Bassiri H,Nichols KE,Stein PL
Sun Feb 01 00:00:00 EST 2009
The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Wolf AM,Eller K,Zeiser R,Dürr C,Gerlach UV,Sixt M,Markut L,Gastl G,Rosenkranz AR,Wolf D
Tue Sep 15 00:00:00 EDT 2009
MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.
Journal of immunology (Baltimore, Md. : 1950)
Wang X,Chang X,Facchinetti V,Zhuang Y,Su B
Sun Mar 15 00:00:00 EDT 2009
Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V alpha 2 down-regulation.
Journal of immunology (Baltimore, Md. : 1950)
Gutermuth J,Nograles KE,Miyagawa F,Nelson E,Cho YH,Katz SI
Tue Sep 01 00:00:00 EDT 2009
Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Jones TG,Hallgren J,Humbles A,Burwell T,Finkelman FD,Alcaide P,Austen KF,Gurish MF
Thu Oct 15 00:00:00 EDT 2009
The adaptor protein Shc plays a key role during early B cell development.
Journal of immunology (Baltimore, Md. : 1950)
Giles AJ,Bender TP,Ravichandran KS
Sun Nov 01 00:00:00 EDT 2009
FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells.
The Journal of biological chemistry
Fukushima K,Matsumura I,Ezoe S,Tokunaga M,Yasumi M,Satoh Y,Shibayama H,Tanaka H,Iwama A,Kanakura Y
Fri Mar 20 00:00:00 EDT 2009
A two-step process for thymic regulatory T cell development.
Immunity
Lio CW,Hsieh CS
Tue Jan 01 00:00:00 EST 2008
H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Cancer cell
Krivtsov AV,Feng Z,Lemieux ME,Faber J,Vempati S,Sinha AU,Xia X,Jesneck J,Bracken AP,Silverman LB,Kutok JL,Kung AL,Armstrong SA
Tue Nov 04 00:00:00 EST 2008
IRF8 regulates B-cell lineage specification, commitment, and differentiation.
Blood
Wang H,Lee CH,Qi C,Tailor P,Feng J,Abbasi S,Atsumi T,Morse HC
Sat Nov 15 00:00:00 EST 2008
Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alphabeta T-cell development.
Blood
Kometani K,Moriyama M,Nakashima Y,Katayama Y,Wang SF,Yamasaki S,Saito T,Hattori M,Minato N
Mon Dec 01 00:00:00 EST 2008
Dissecting T cell lineage relationships by cellular barcoding.
The Journal of experimental medicine
Schepers K,Swart E,van Heijst JW,Gerlach C,Castrucci M,Sie D,Heimerikx M,Velds A,Kerkhoven RM,Arens R,Schumacher TN
Mon Sep 29 00:00:00 EDT 2008
Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria.
PLoS pathogens
Sada-Ovalle I,Chiba A,Gonzales A,Brenner MB,Behar SM
Mon Dec 01 00:00:00 EST 2008
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B
Sat Dec 15 00:00:00 EST 2007
Murine plasmacytoid dendritic cells produce IFN-gamma upon IL-4 stimulation.
Journal of immunology (Baltimore, Md. : 1950)
Suto A,Nakajima H,Tokumasa N,Takatori H,Kagami S,Suzuki K,Iwamoto I
Tue Nov 01 00:00:00 EST 2005
Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells.
The Journal of biological chemistry
Cornish AL,Chong MM,Davey GM,Darwiche R,Nicola NA,Hilton DJ,Kay TW,Starr R,Alexander WS
Fri Jun 20 00:00:00 EDT 2003
Homeostatic T cell proliferation in a T cell-dendritic cell coculture system.
Proceedings of the National Academy of Sciences of the United States of America
Ge Q,Palliser D,Eisen HN,Chen J
Tue Mar 05 00:00:00 EST 2002
