Gibco

Mouse SCF Recombinant Protein, PeproTech®

Mouse SCF Protein in Functional Assay (Functional)

FIGURE: 1 / 1

Mouse SCF Protein (250-03-10UG) in Functional

Bioassay analysis of Mouse SCF Recombinant Protein, PeproTech® (Product # 250-03-1MG).

Product Image Gallery

Product Details

250-03-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

Flow Cytometry (Flow)

View 2 publications 2 publications

ELISA (ELISA)

Assay-dependent

Neutralization (Neu)

View 1 publication 1 publication

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 756 publications 756 publications

Miscellaneous PubMed (Misc)

View 71 publications 71 publications

Product Specifications

Species

Mouse

Published species

Avian, Chicken, Hamster, Human, Mouse, Rat, Virus

Expression System

E. coli

Amino acid sequence

MKEICGNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV IQLSLSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVLC MEENAPKNIK ESPKRPETRS FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA

Molecular weight

18.3 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 as determined by the dose-dependent stimulation of the proliferation of the human TF-1 cells is ≤ 10 ng/ml, corresponding to a specific activity of ≥ 1 x 10^5 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Murine SCF is an 18.3 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Eosinophils protect against pulmonary hypertension through 14-HDHA and 17-HDHA.

The European respiratory journal

Shu T,Zhang J,Zhou Y,Chen Z,Li J,Tang Q,Lei W,Xing Y,Wang J,Wang C

250-03 was used in Cell Culture to show that in PH development without external inflammatory stimulus, peripheral blood exhibits a low EOS level, in which EOS play a protective role through suppressing perivascular inflammation and maintaining PASMC homeostasis via 14/17-HDHA.

Wed Mar 01 00:00:00 EST 2023

Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J

250-03 was used in In vitro experiments to establish both direct and indirect roles for ILC2 in peri-aortic CaPO4 injury-induced mouse abdominal aortic aneurysms.

Wed Mar 01 00:00:00 EST 2023

The constitutively active pSMAD2/3 relatively improves the proliferation of chicken primordial germ cells.

Molecular reproduction and development

Zare M,Mirhoseini SZ,Ghovvati S,Yakhkeshi S,Hesaraki M,Barati M,Sayyahpour FA,Baharvand H,Hassani SN

250-03 was used in Cell Culture to show that TGF-β signaling agonists (IDE1 and Activin-A) improved PGC proliferation to some extent while treatment with SB431542, the antagonist of TGF-β, disrupted PGCs' proliferation.

Thu Jun 01 00:00:00 EDT 2023

Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.

Cancer discovery

Liu Y,Li Q,Alikarami F,Barrett DR,Mahdavi L,Li H,Tang S,Khan TA,Michino M,Hill C,Song L,Yang L,Li Y,Pokharel SP,Stamford AW,Liverton N,Renzetti LM,Taylor S,Watt GF,Ladduwahetty T,Kargman S,Meinke PT,Foley MA,Shi J,Li H,Carroll M,Chen CW,Gardini A,Maillard I,Huggins DJ,Bernt KM,Wan L

250-03 was used in Cell Culture to study the therapeutic potential of chromatin reader eleven-nineteen leukemia (ENL) dependency in acute myeloid leukemia (AML).

Wed Nov 02 00:00:00 EDT 2022

PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen.

The Journal of experimental medicine

Liu M,Wu C,Luo S,Hua Q,Chen HT,Weng Y,Xu J,Lin H,Wang L,Li J,Zhu L,Guo Z,Zhuang SM,Kang T,Zheng L

250-03 was used in Sample Preparation (FC/FACS) to indicate that PERK-mediated HSPC preconditioning plays a crucial role in MDSC generation, suggesting novel spleen-targeting therapeutic opportunities for restraining the tumor-promoting myeloid response at its source.

Mon Apr 04 00:00:00 EDT 2022

Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.

The Journal of experimental medicine

Ahmed N,Etzrodt M,Dettinger P,Kull T,Loeffler D,Hoppe PS,Chavez JS,Zhang Y,Camargo Ortega G,Hilsenbeck O,Nakajima H,Pietras EM,Schroeder T

Mon Jan 03 00:00:00 EST 2022

Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.

Blood advances

Xu JJ,Chalk AM,Nikolic I,Simpson KJ,Smeets MF,Walkley CR

Tue Apr 12 00:00:00 EDT 2022

Siglec-F Promotes IL-33-Induced Cytokine Release from Bone Marrow-Derived Eosinophils Independently of the ITIM and ITIM-like Motif Phosphorylation.

Journal of immunology (Baltimore, Md. : 1950)

Westermann S,Dietschmann A,Doehler D,Castiglione K,Bochner BS,Voehringer D,Radtke D

Tue Feb 01 00:00:00 EST 2022

OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis.

Frontiers in immunology

Xu L,Tian D,Zhou M,Ma J,Sun G,Jin H,Li M,Zhang D,Wu J

250-03 was used in Cell Culture to show that Ox40 deficiency dampened the Traf2/6-related NF-κB signaling pathway in eosinophils.

Tue Jun 21 00:00:00 EDT 2022

Skin-resident innate lymphoid cells converge on a pathogenic effector state.

Nature

Bielecki P,Riesenfeld SJ,Hütter JC,Torlai Triglia E,Kowalczyk MS,Ricardo-Gonzalez RR,Lian M,Amezcua Vesely MC,Kroehling L,Xu H,Slyper M,Muus C,Ludwig LS,Christian E,Tao L,Kedaigle AJ,Steach HR,York AG,Skadow MH,Yaghoubi P,Dionne D,Jarret A,McGee HM,Porter CBM,Licona-Limón P,Bailis W,Jackson R,Gagliani N,Gasteiger G,Locksley RM,Regev A,Flavell RA

250-03 was used in Sample Preparation (FC/FACS) to investigate cytokine production by tissue-resident innate lymphoid cells.

Thu Apr 01 00:00:00 EDT 2021

Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis.

Cell

Zhang S,Edwards TN,Chaudhri VK,Wu J,Cohen JA,Hirai T,Rittenhouse N,Schmitz EG,Zhou PY,McNeil BD,Yang Y,Koerber HR,Sumpter TL,Poholek AC,Davis BM,Albers KM,Singh H,Kaplan DH

Thu Apr 15 00:00:00 EDT 2021

Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells.

Cell research

Liu C,Gong Y,Zhang H,Yang H,Zeng Y,Bian Z,Xin Q,Bai Z,Zhang M,He J,Yan J,Zhou J,Li Z,Ni Y,Wen A,Lan Y,Hu H,Liu B

Fri Oct 01 00:00:00 EDT 2021

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection.

Immunity

Flommersfeld S,Böttcher JP,Ersching J,Flossdorf M,Meiser P,Pachmayr LO,Leube J,Hensel I,Jarosch S,Zhang Q,Chaudhry MZ,Andrae I,Schiemann M,Busch DH,Cicin-Sain L,Sun JC,Gasteiger G,Victora GD,Höfer T,Buchholz VR,Grassmann S

Tue Oct 12 00:00:00 EDT 2021

Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis.

Immunity

Roberto MP,Varano G,Vinas-Castells R,Holmes AB,Kumar R,Pasqualucci L,Farinha P,Scott DW,Dominguez-Sola D

Tue Aug 10 00:00:00 EDT 2021

Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.

Nature genetics

Yun H,Narayan N,Vohra S,Giotopoulos G,Mupo A,Madrigal P,Sasca D,Lara-Astiaso D,Horton SJ,Agrawal-Singh S,Meduri E,Basheer F,Marando L,Gozdecka M,Dovey OM,Castillo-Venzor A,Wang X,Gallipoli P,Müller-Tidow C,Osborne CS,Vassiliou GS,Huntly BJP

Fri Oct 01 00:00:00 EDT 2021

The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability.

Blood

Tu Z,Wang C,Davis AK,Hu M,Zhao C,Xin M,Lu QR,Zheng Y

Thu Jul 22 00:00:00 EDT 2021

Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging.

Cell stem cell

Kruta M,Sunshine MJ,Chua BA,Fu Y,Chawla A,Dillingham CH,Hidalgo San Jose L,De Jong B,Zhou FJ,Signer RAJ

Thu Nov 04 00:00:00 EDT 2021

Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis.

Cell stem cell

Leimkühler NB,Gleitz HFE,Ronghui L,Snoeren IAM,Fuchs SNR,Nagai JS,Banjanin B,Lam KH,Vogl T,Kuppe C,Stalmann USA,Büsche G,Kreipe H,Gütgemann I,Krebs P,Banz Y,Boor P,Tai EW,Brümmendorf TH,Koschmieder S,Crysandt M,Bindels E,Kramann R,Costa IG,Schneider RK

Thu Apr 01 00:00:00 EDT 2021

HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.

Cell stem cell

Lv K,Gong C,Antony C,Han X,Ren JG,Donaghy R,Cheng Y,Pellegrino S,Warren AJ,Paralkar VR,Tong W

250-03 was used in In vitro experiments to reveal a role of the E3 ubiquitin ligase HectD1 in regulating HSC function via ribosome assembly and protein translation.

Thu Jul 01 00:00:00 EDT 2021

Liver X receptor β is required for the survival of single-positive thymocytes by regulating IL-7Rα expression.

Cellular & molecular immunology

Huang H,Wu X,Meng D,Feng Y,Zhou L,Liu Z,Tang S,Li X,Cao Y,He H,Xie Z,Zhang J,Chen Y,Zhao T,Wu Y,Zhou X

250-03 was used in Cell Culture to indicate that LXRβ functions as an important transcription factor upstream of IL-7Rα to promote the survival of SP thymocytes.

Sun Aug 01 00:00:00 EDT 2021

SRSF1 plays a critical role in invariant natural killer T cell development and function.

Cellular & molecular immunology

Liu J,You M,Yao Y,Ji C,Wang Z,Wang F,Wang D,Qi Z,Yu G,Sun Z,Guo W,Liu J,Li S,Jin Y,Zhao T,Xue HH,Xue Y,Yu S

Mon Nov 01 00:00:00 EDT 2021

Multiorgan failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes.

The Journal of clinical investigation

Nagamachi A,Kanai A,Nakamura M,Okuda H,Yokoyama A,Shinriki S,Matsui H,Inaba T

Mon Feb 15 00:00:00 EST 2021

Multiorgan failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes.

The Journal of clinical investigation

Nagamachi A,Kanai A,Nakamura M,Okuda H,Yokoyama A,Shinriki S,Matsui H,Inaba T

Mon Feb 15 00:00:00 EST 2021

ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.

Molecular cell

Di Marcantonio D,Martinez E,Kanefsky JS,Huhn JM,Gabbasov R,Gupta A,Krais JJ,Peri S,Tan Y,Skorski T,Dorrance A,Garzon R,Goldman AR,Tang HY,Johnson N,Sykes SM

250-03 was used in Cell Culture to investigate the role of ATF3 expression on cell cycle progression in acute myeloid leukemia.

Thu Jul 01 00:00:00 EDT 2021

METTL1-mediated m⁷G modification of Arg-TCT tRNA drives oncogenic transformation.

Molecular cell

Orellana EA,Liu Q,Yankova E,Pirouz M,De Braekeleer E,Zhang W,Lim J,Aspris D,Sendinc E,Garyfallos DA,Gu M,Ali R,Gutierrez A,Mikutis S,Bernardes GJL,Fischer ES,Bradley A,Vassiliou GS,Slack FJ,Tzelepis K,Gregory RI

250-03 was used in Cell Culture to conclude that METTL1-mediated tRNA modification drives oncogenic transformation through a remodeling of the mRNA translatome" to increase expression of growth-promoting proteins and represents a promising anti-cancer target."

Thu Aug 19 00:00:00 EDT 2021

Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.

The Journal of experimental medicine

Cova G,Taroni C,Deau MC,Cai Q,Mittelheisser V,Philipps M,Jung M,Cerciat M,Le Gras S,Thibault-Carpentier C,Jost B,Carlsson L,Thornton AM,Shevach EM,Kirstetter P,Kastner P,Chan S

Mon Oct 04 00:00:00 EDT 2021

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.

The Journal of experimental medicine

Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E

Mon Jul 05 00:00:00 EDT 2021

The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.

The Journal of experimental medicine

Stamos DB,Clubb LM,Mitra A,Chopp LB,Nie J,Ding Y,Das A,Venkataganesh H,Lee J,El-Khoury D,Li L,Bhandoola A,Bosselut R,Love PE

Mon Dec 06 00:00:00 EST 2021

Low-affinity but high-avidity interactions may offer an explanation for IgE-mediated allergen cross-reactivity.

Allergy

Chang X,Zha L,Wallimann A,Mohsen MO,Krenger P,Liu X,Vogel M,Bachmann MF

250-03 was used in In vitro experiments to suggest that the underlying mechanism of allergen cross-reactivity may be low-affinity but high-avidity binding between IgE antibodies and cross-reactive allergen.

Sun Aug 01 00:00:00 EDT 2021

Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.

EMBO molecular medicine

Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P

Fri Mar 05 00:00:00 EST 2021

Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.

Leukemia

Thomas ME,Abdelhamed S,Hiltenbrand R,Schwartz JR,Sakurada SM,Walsh M,Song G,Ma J,Pruett-Miller SM,Klco JM

Mon Nov 01 00:00:00 EDT 2021

Granulocyte colony-stimulating factor directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells.

Haematologica

Xie M,Zhang S,Dong F,Zhang Q,Wang J,Wang C,Zhu C,Zhang S,Luo B,Wu P,Ema H

250-03 was used in Cell Culture to investigate whether granulocyte colony-stimulating factor directly stimulates hematopoietic stem cells to change their cell cycle state and fate.

Tue Jun 01 00:00:00 EDT 2021

C/EBP homologous protein deficiency enhances hematopoietic stem cell function via reducing ATF3/ROS-induced cell apoptosis.

Aging cell

Shi Z,Diao D,Zhao Y,Luo Y,Li Y,Liu D,Zhang K,Qiu Y,Yu L,Song Z,Ju Z

250-03 was used in Cell Culture to show that C/EBP homologous protein (CHOP) has a significant role in supporting HSCs homesotasis and by reducing ATF3/ROS signalling, it promotes their regeneration.

Thu Jul 01 00:00:00 EDT 2021

The anti-parasitic drug miltefosine suppresses activation of human eosinophils and ameliorates allergic inflammation in mice.

British journal of pharmacology

Knuplez E,Kienzl M,Trakaki A,Schicho R,Heinemann A,Sturm EM,Marsche G

250-03 was used in Sample Preparation (FC/FACS) to underline the potential efficacy of miltefosine in the treatment of allergic diseases and other eosinophil-associated disorders and may raise important questions regarding the immunomodulatory effect of miltefosine in patients treated for leishmania infections.

Mon Mar 01 00:00:00 EST 2021

Regeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response.

EMBO reports

Gutiérrez-Gutiérrez Ó,Felix DA,Salvetti A,Amro EM,Thems A,Pietsch S,Koeberle A,Rudolph KL,González-Estévez C

Wed Aug 04 00:00:00 EDT 2021

High-throughput screening in postimplantation haploid epiblast stem cells reveals Hs3st3b1 as a modulator for reprogramming.

Stem cells translational medicine

Gao Q,Zhang W,Zhao Y,Tian Y,Wang Y,Zhang J,Geng M,Xu M,Yao C,Wang H,Li L,Liu Y,Shuai L

Sat May 01 00:00:00 EDT 2021

CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis.

Blood advances

Gerosa RC,Boettcher S,Kovtonyuk LV,Hausmann A,Hardt WD,Hidalgo J,Nombela-Arrieta C,Manz MG

Tue Dec 14 00:00:00 EST 2021

5-Azacytidine depletes HSCs and synergizes with an anti-CD117 antibody to augment donor engraftment in immunocompetent mice.

Blood advances

Bankova AK,Pang WW,Velasco BJ,Long-Boyle JR,Shizuru JA

Tue Oct 12 00:00:00 EDT 2021

Oxidized mitochondrial DNA released after inflammasome activation is a disease biomarker for myelodysplastic syndromes.

Blood advances

Ward GA,McGraw KL,Abbas-Aghababazadeh F,Meyer BS,McLemore AF,Vincelette ND,Lam NB,Aldrich AL,Al Ali NH,Padron E,Pinilla-Ibarz J,Masala E,Santini V,Kosmider O,Fontenay M,Fenaux P,Johnson J,Fridley BL,List AF

Tue Apr 27 00:00:00 EDT 2021

IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt⁺ T_reg generation via enhanced IL-6 induction.

Immunology

Drube S,Müller S,Weber F,Wegner P,Böttcher-Loschinski R,Gaestel M,Hutloff A,Kamradt T,Andreas N

Sat May 01 00:00:00 EDT 2021

A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.

Computational and structural biotechnology journal

Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F

250-03 was used in In vitro experiments to present a rapid experimental approach to identify potential drug targets related to mature immune cells, as well as normal and malignant hematopoiesis.

Wed Nov 10 00:00:00 EST 2021

Development of an Optimized Culture System for Generating Mouse Alveolar Macrophage-like Cells.

Journal of immunology (Baltimore, Md. : 1950)

Luo M,Lai W,He Z,Wu L

Wed Sep 15 00:00:00 EDT 2021

B Lymphocyte Specification Is Preceded by Extensive Epigenetic Priming in Multipotent Progenitors.

Journal of immunology (Baltimore, Md. : 1950)

Strid T,Okuyama K,Tingvall-Gustafsson J,Kuruvilla J,Jensen CT,Lang S,Prasad M,Somasundaram R,Åhsberg J,Cristobal S,Soneji S,Ungerbäck J,Sigvardsson M

Tue Jun 01 00:00:00 EDT 2021

Acidic Calcium-Independent Phospholipase A2 Regulates Eosinophil-Mediated Pathology during Filarial Manifestation of Tropical Pulmonary Eosinophilia.

Journal of immunology (Baltimore, Md. : 1950)

Sharma P,Sharma A,Ganga L,Satoeya N,Jha R,Srivastava M

Mon Feb 15 00:00:00 EST 2021

A Critical Role for Na⁺/H⁺ Exchanger Regulatory Factor 1 in Modulating FcεRI-Mediated Mast Cell Activation.

Journal of immunology (Baltimore, Md. : 1950)

Kammala AK,Syed M,Yang C,Occhiuto CJ,Subramanian H

Mon Feb 01 00:00:00 EST 2021

The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Xie B,Khoyratty TE,Abu-Shah E,F Cespedes P,MacLean AJ,Pirgova G,Hu Z,Ahmed AA,Dustin ML,Udalova IA,Arnon TI

Thu Apr 01 00:00:00 EDT 2021

Divergent roles for KLF4 and TFCP2L1 in naive ground state pluripotency and human primordial germ cell development.

Stem cell research

Hancock GV,Liu W,Peretz L,Chen D,Gell JJ,Collier AJ,Zamudio JR,Plath K,Clark AT

250-03 was used in Cell Culture to evaluate the role of KLF4 and TFCP2L1 in human primordial germ cell development.

Sun Aug 01 00:00:00 EDT 2021

Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells.

Nature communications

Jia W,Kong L,Kidoya H,Naito H,Muramatsu F,Hayashi Y,Hsieh HY,Yamakawa D,Hsu DK,Liu FT,Takakura N

Fri Apr 09 00:00:00 EDT 2021

BRD4-mediated repression of p53 is a target for combination therapy in AML.

Nature communications

Latif AL,Newcombe A,Li S,Gilroy K,Robertson NA,Lei X,Stewart HJS,Cole J,Terradas MT,Rishi L,McGarry L,McKeeve C,Reid C,Clark W,Campos J,Kirschner K,Davis A,Lopez J,Sakamaki JI,Morton JP,Ryan KM,Tait SWG,Abraham SA,Holyoake T,Higgins B,Huang X,Blyth K,Copland M,Chevassut TJT,Keeshan K,Adams PD

Mon Jan 11 00:00:00 EST 2021

NAD⁺ augmentation with nicotinamide riboside improves lymphoid potential of Atm^-/- and old mice HSCs.

NPJ aging and mechanisms of disease

Zong L,Tanaka-Yano M,Park B,Yanai H,Turhan FT,Croteau DL,Tian J,Fang EF,Bohr VA,Beerman I

Tue Sep 21 00:00:00 EDT 2021

Engineering of a bona fide light-operated calcium channel.

Nature communications

He L,Wang L,Zeng H,Tan P,Ma G,Zheng S,Li Y,Sun L,Dou F,Siwko S,Huang Y,Wang Y,Zhou Y

Mon Jan 11 00:00:00 EST 2021

Protocol to produce high-titer retrovirus for transduction of mouse bone marrow cells.

STAR protocols

Qu J,Yang Z

250-03 was used in Cell Culture to demonstrate a modified protocol to overcome challenges associated with achieving high transduction efficiency in bone marrow cells in transplantation which enables reproducible and high-efficient retroviral transduction of hematopoietic stem and progenitor cells (HSPCs) for bone marrow transplantation (BMT).

Fri Jun 18 00:00:00 EDT 2021

Multi-scale Dynamical Modeling of T Cell Development from an Early Thymic Progenitor State to Lineage Commitment.

Cell reports

Olariu V,Yui MA,Krupinski P,Zhou W,Deichmann J,Andersson E,Rothenberg EV,Peterson C

Tue Jan 12 00:00:00 EST 2021

Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice.

Cell reports

Kim SP,Srivatsan SN,Chavez M,Shirai CL,White BS,Ahmed T,Alberti MO,Shao J,Nunley R,White LS,Bednarski J,Pehrson JR,Walter MJ

Tue Aug 31 00:00:00 EDT 2021

Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo.

Cell reports

Dignum T,Varnum-Finney B,Srivatsan SR,Dozono S,Waltner O,Heck AM,Ishida T,Nourigat-McKay C,Jackson DL,Rafii S,Trapnell C,Bernstein ID,Hadland B

Tue Sep 14 00:00:00 EDT 2021

SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.

Journal of experimental & clinical cancer research : CR

Wang F,Li Z,Zhou J,Wang G,Zhang W,Xu J,Liang A

250-03 was used in Cell Culture to investigate SIRT1 expression and function in T-cell acute lymphoblastic leukemia.

Wed Aug 18 00:00:00 EDT 2021

Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses.

Cell reports

Yu K,Hammerschmidt SI,Permanyer M,Galla M,Rothe M,Zheng X,Werth K,Martens R,Lueder Y,Janssen A,Friedrichsen M,Bernhardt G,Förster R

Tue Jun 22 00:00:00 EDT 2021

Correction of pathology in mice displaying Gaucher disease type 1 by a clinically-applicable lentiviral vector.

Molecular therapy. Methods & clinical development

Dahl M,Smith EMK,Warsi S,Rothe M,Ferraz MJ,Aerts JMFG,Golipour A,Harper C,Pfeifer R,Pizzurro D,Schambach A,Mason C,Karlsson S

Fri Mar 12 00:00:00 EST 2021

ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.

Nature communications

Li J,Galbo PM,Gong W,Storey AJ,Tsai YH,Yu X,Ahn JH,Guo Y,Mackintosh SG,Edmondson RD,Byrum SD,Farrar JE,He S,Cai L,Jin J,Tackett AJ,Zheng D,Wang GG

Tue Feb 16 00:00:00 EST 2021

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.

Nature communications

Debackere K,Marcelis L,Demeyer S,Vanden Bempt M,Mentens N,Gielen O,Jacobs K,Broux M,Verhoef G,Michaux L,Graux C,Wlodarska I,Gaulard P,de Leval L,Tousseyn T,Cools J,Dierickx D

Thu Jun 17 00:00:00 EDT 2021

Protocols for isolation and characterization of mouse placental hemogenic endothelial cells.

STAR protocols

Liang G,Huang B,Wang F,Liu F

250-03 was used in Flow cytometry/Cell sorting to describe a protocol for isolation and characterization of the hemogenic endothelial (HE) cells from mouse placenta.

Fri Dec 17 00:00:00 EST 2021

Syngeneic leukemia models using lentiviral transgenics.

Cell death & disease

Keinan N,Scharff Y,Goldstein O,Chamo M,Ilic S,Gazit R

Thu Feb 18 00:00:00 EST 2021

GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis.

Cell death & disease

Hu Q,Zhang Y,Lou H,Ou Z,Liu J,Duan W,Wang H,Ge Y,Min J,Wang F,Ju Z

Thu Jul 15 00:00:00 EDT 2021

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors.

Nature communications

Khateb A,Deshpande A,Feng Y,Finlay D,Lee JS,Lazar I,Fabre B,Li Y,Fujita Y,Zhang T,Yin J,Pass I,Livneh I,Jeremias I,Burian C,Mason JR,Almog R,Horesh N,Ofran Y,Brown K,Vuori K,Jackson M,Ruppin E,Deshpande AJ,Ronai ZA

Mon Sep 13 00:00:00 EDT 2021

High-resolution characterization of gene function using single-cell CRISPR tiling screen.

Nature communications

Yang L,Chan AKN,Miyashita K,Delaney CD,Wang X,Li H,Pokharel SP,Li S,Li M,Xu X,Lu W,Liu Q,Mattson N,Chen KY,Wang J,Yuan YC,Horne D,Rosen ST,Soto-Feliciano Y,Feng Z,Hoshii T,Xiao G,Müschen M,Chen J,Armstrong SA,Chen CW

Thu Jul 01 00:00:00 EDT 2021

Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory.

Scientific reports

Stahlhut M,Ha TC,Takmakova E,Morgan MA,Schwarzer A,Schaudien D,Eder M,Schambach A,Kustikova OS

Fri Mar 05 00:00:00 EST 2021

Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells.

Science advances

Pessoa Rodrigues C,Akhtar A

250-03 was used in Cell Culture to indicate H4K16ac as an important determinant for HSC heterogeneity, which is linked to the onset of monocytic disorders.

Sun Aug 01 00:00:00 EDT 2021

TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9.

iScience

Zhao J,Xiu Y,Fu L,Dong Q,Borcherding N,Wang Y,Li Q,De Silva NS,Klein U,Boyce BF,Zhao C

250-03 was used in Cell Culture to investigate NF-kB deletion effects on MLL-AF9-AML.

Fri Dec 17 00:00:00 EST 2021

Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells.

eLife

Kiritsy MC,McCann K,Mott D,Holland SM,Behar SM,Sassetti CM,Olive AJ

250-03 was used in Cell Culture to study the metabolic dependencies of critical signals such as interferon gamma (IFNγ) for allowing antigen-presenting cells (APCs) to convey a wide array of functionally distinct signals to T cells. To demonstrate that IFNγ response requires mitochondrial respiration, and APCs are unable to activate T cells upon genetic or chemical inhibition of complex I.

Tue Nov 02 00:00:00 EDT 2021

TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.

Cell reports

Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R

Tue Jul 13 00:00:00 EDT 2021

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia.

Nature communications

Van Thillo Q,De Bie J,Seneviratne JA,Demeyer S,Omari S,Balachandran A,Zhai V,Tam WL,Sweron B,Geerdens E,Gielen O,Provost S,Segers H,Boeckx N,Marshall GM,Cheung BB,Isobe K,Kato I,Takita J,Amos TG,Deveson IW,McCalmont H,Lock RB,Oxley EP,Garwood MM,Dickins RA,Uyttebroeck A,Carter DR,Cools J,de Bock CE

Tue Jul 06 00:00:00 EDT 2021

Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells.

Communications biology

Rore H,Owen N,Piña-Aguilar RE,Docherty K,Sekido R

Mon Jun 28 00:00:00 EDT 2021

Microfilariae Trigger Eosinophil Extracellular DNA Traps in a Dectin-1-Dependent Manner.

Cell reports

Ehrens A,Lenz B,Neumann AL,Giarrizzo S,Reichwald JJ,Frohberger SJ,Stamminger W,Buerfent BC,Fercoq F,Martin C,Kulke D,Hoerauf A,Hübner MP

Tue Jan 12 00:00:00 EST 2021

Modulation of APLNR Signaling Is Required during the Development and Maintenance of the Hematopoietic System.

Stem cell reports

Jackson M,Fidanza A,Taylor AH,Rybtsov S,Axton R,Kydonaki M,Meek S,Burdon T,Medvinsky A,Forrester LM

Tue Apr 13 00:00:00 EDT 2021

Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.

Nature communications

Supper E,Rudat S,Iyer V,Droop A,Wong K,Spinella JF,Thomas P,Sauvageau G,Adams DJ,Wong CC

Fri Apr 30 00:00:00 EDT 2021

GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis.

Blood science (Baltimore, Md.)

Yang X,Cong T,He H,Wang J

250-03 was used in Cell Culture to reveal that GSDME modulates HSC function by coordinating pyroptosis and apoptosis.

Thu Apr 01 00:00:00 EDT 2021

Tunable, division-independent control of gene activation timing by a polycomb switch.

Cell reports

Pease NA,Nguyen PHB,Woodworth MA,Ng KKH,Irwin B,Vaughan JC,Kueh HY

Tue Mar 23 00:00:00 EDT 2021

OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy.

Cell reports

Murakami K,Kurotaki D,Kawase W,Soma S,Fukuchi Y,Kunimoto H,Yoshimi R,Koide S,Oshima M,Hishiki T,Hayakawa N,Matsuura T,Oda M,Yanagisawa K,Kobayashi H,Haraguchi M,Atobe Y,Funakoshi K,Iwama A,Takubo K,Okamoto S,Tamura T,Nakajima H

Tue Jan 05 00:00:00 EST 2021

Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector.

Molecular therapy. Methods & clinical development

Seymour BJ,Singh S,Certo HM,Sommer K,Sather BD,Khim S,Clough C,Hale M,Pangallo J,Ryu BY,Khan IF,Adair JE,Rawlings DJ

Fri Mar 12 00:00:00 EST 2021

Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues.

Immunity

Guendel F,Kofoed-Branzk M,Gronke K,Tizian C,Witkowski M,Cheng HW,Heinz GA,Heinrich F,Durek P,Norris PS,Ware CF,Ruedl C,Herold S,Pfeffer K,Hehlgans T,Waisman A,Becher B,Giannou AD,Brachs S,Ebert K,Tanriver Y,Ludewig B,Mashreghi MF,Kruglov AA,Diefenbach A

Tue Nov 17 00:00:00 EST 2020

High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity.

Immunity

Kim S,Bagadia P,Anderson DA,Liu TT,Huang X,Theisen DJ,O'Connor KW,Ohara RA,Iwata A,Murphy TL,Murphy KM

Tue Oct 13 00:00:00 EDT 2020

In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors.

Immunity

Zeis P,Lian M,Fan X,Herman JS,Hernandez DC,Gentek R,Elias S,Symowski C,Knöpper K,Peltokangas N,Friedrich C,Doucet-Ladeveze R,Kabat AM,Locksley RM,Voehringer D,Bajenoff M,Rudensky AY,Romagnani C,Grün D,Gasteiger G

Tue Oct 13 00:00:00 EDT 2020

Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.

Cancer cell

Witkowski MT,Dolgalev I,Evensen NA,Ma C,Chambers T,Roberts KG,Sreeram S,Dai Y,Tikhonova AN,Lasry A,Qu C,Pei D,Cheng C,Robbins GA,Pierro J,Selvaraj S,Mezzano V,Daves M,Lupo PJ,Scheurer ME,Loomis CA,Mullighan CG,Chen W,Rabin KR,Tsirigos A,Carroll WL,Aifantis I

Mon Jun 08 00:00:00 EDT 2020

C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.

Cancer cell

Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C

Mon May 11 00:00:00 EDT 2020

Vitamin B6 Addiction in Acute Myeloid Leukemia.

Cancer cell

Chen CC,Li B,Millman SE,Chen C,Li X,Morris JP,Mayle A,Ho YJ,Loizou E,Liu H,Qin W,Shah H,Violante S,Cross JR,Lowe SW,Zhang L

Mon Jan 13 00:00:00 EST 2020

SIRT1 is downregulated by autophagy in senescence and ageing.

Nature cell biology

Xu C,Wang L,Fozouni P,Evjen G,Chandra V,Jiang J,Lu C,Nicastri M,Bretz C,Winkler JD,Amaravadi R,Garcia BA,Adams PD,Ott M,Tong W,Johansen T,Dou Z,Berger SL

250-03 was used in In vitro experiments to investigate SIRT1 homeostasis in mammalian senescence and aging.

Thu Oct 01 00:00:00 EDT 2020

Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.

Blood

Zambetti NA,Firestone AJ,Remsberg JR,Huang BJ,Wong JC,Long AM,Predovic M,Suciu RM,Inguva A,Kogan SC,Haigis KM,Cravatt BF,Shannon K

Thu May 14 00:00:00 EDT 2020

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1.

Blood

Carmichael CL,Wang J,Nguyen T,Kolawole O,Benyoucef A,De Mazière C,Milne AR,Samuel S,Gillinder K,Hediyeh-Zadeh S,Vo ANQ,Huang Y,Knezevic K,McInnes WRL,Shields BJ,Mitchell H,Ritchie ME,Lammens T,Lintermans B,Van Vlierberghe P,Wong NC,Haigh K,Thoms JAI,Toulmin E,Curtis DJ,Oxley EP,Dickins RA,Beck D,Perkins A,McCormack MP,Davis MJ,Berx G,Zuber J,Pimanda JE,Kile BT,Goossens S,Haigh JJ

Thu Aug 20 00:00:00 EDT 2020

Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.

Blood

Numata A,Kwok HS,Zhou QL,Li J,Tirado-Magallanes R,Angarica VE,Hannah R,Park J,Wang CQ,Krishnan V,Rajagopalan D,Zhang Y,Zhou S,Welner RS,Osato M,Jha S,Bohlander SK,Göttgens B,Yang H,Benoukraf T,Lough JW,Bararia D,Tenen DG

Thu Oct 08 00:00:00 EDT 2020

Aging-induced IL27Ra signaling impairs hematopoietic stem cells.

Blood

He H,Xu P,Zhang X,Liao M,Dong Q,Cong T,Tang B,Yang X,Ye M,Chang Y,Liu W,Wang X,Ju Z,Wang J

Thu Jul 09 00:00:00 EDT 2020

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.

Cell stem cell

Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J

250-03 was used in In vitro experiments to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.

Thu Jul 02 00:00:00 EDT 2020

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition.

Cell stem cell

Hinge A,He J,Bartram J,Javier J,Xu J,Fjellman E,Sesaki H,Li T,Yu J,Wunderlich M,Mulloy J,Kofron M,Salomonis N,Grimes HL,Filippi MD

250-03 was used in In vitro experiments to investigate the underlying role of mitochondria in hematopoietic stem cells (HSCs) to meet change of metabolic requirements during their cell cycle activity.

Thu Mar 05 00:00:00 EST 2020

Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.

The Journal of clinical investigation

Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F

250-03 was used in Cell Culture to the impact of the constitutive activation of stress signaling pathways on hematopoietic stem cell maintenance and function in Fanconi anemia.

Mon Mar 02 00:00:00 EST 2020

Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.

The Journal of clinical investigation

Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F

250-03 was used in Cell Culture to the impact of the constitutive activation of stress signaling pathways on hematopoietic stem cell maintenance and function in Fanconi anemia.

Mon Mar 02 00:00:00 EST 2020

Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.

The Journal of experimental medicine

Kang YA,Pietras EM,Passegué E

Mon Mar 02 00:00:00 EST 2020

Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis.

The Journal of experimental medicine

Xiong Z,Xia P,Zhu X,Geng J,Wang S,Ye B,Qin X,Qu Y,He L,Fan D,Du Y,Tian Y,Fan Z

Mon Feb 03 00:00:00 EST 2020

Endothelial mTOR maintains hematopoiesis during aging.

The Journal of experimental medicine

Ramalingam P,Poulos MG,Gutkin MC,Katsnelson L,Freire AG,Lazzari E,Butler JM

Mon Jun 01 00:00:00 EDT 2020

The human fetal thymus generates invariant effector γδ T cells.

The Journal of experimental medicine

Tieppo P,Papadopoulou M,Gatti D,McGovern N,Chan JKY,Gosselin F,Goetgeluk G,Weening K,Ma L,Dauby N,Cogan A,Donner C,Ginhoux F,Vandekerckhove B,Vermijlen D

Mon Mar 02 00:00:00 EST 2020

The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses.

The Journal of experimental medicine

Arnold IC,Artola-Boran M,Gurtner A,Bertram K,Bauer M,Frangez Z,Becher B,Kopf M,Yousefi S,Simon HU,Tzankov A,Müller A

Mon Dec 07 00:00:00 EST 2020

PEDF promotes the repair of bone marrow endothelial cell injury and accelerates hematopoietic reconstruction after bone marrow transplantation.

Journal of biomedical science

Ju W,Lu W,Ding L,Bao Y,Hong F,Chen Y,Gao H,Xu X,Wang G,Wang W,Zhang X,Fu C,Qi K,Li Z,Xu K,Qiao J,Zeng L

250-03 was used in Cell Culture to investigate pigment epithelium-derived factor's effect on preconditioning induced damage of endothelial cells and hematopoietic reconstructioncon.

Tue Sep 01 00:00:00 EDT 2020

Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal.

Cell systems

Arai F,Stumpf PS,Ikushima YM,Hosokawa K,Roch A,Lutolf MP,Suda T,MacArthur BD

250-03 was used in Cell Culture to indicate that the balance between intrinsic and extrinsic regulation of stem cell activity alters substantially with age and help explain why stem cell numbers increase through life, yet regenerative potency declines.

Wed Dec 16 00:00:00 EST 2020

Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.

EMBO reports

Szade K,Zukowska M,Szade A,Nowak W,Skulimowska I,Ciesla M,Bukowska-Strakova K,Gulati GS,Kachamakova-Trojanowska N,Kusienicka A,Einwallner E,Kijowski J,Czauderna S,Esterbauer H,Benes V,L Weissman I,Dulak J,Jozkowicz A

Wed Feb 05 00:00:00 EST 2020

Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.

EMBO reports

Wed Feb 05 00:00:00 EST 2020

The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.

Journal of immunology (Baltimore, Md. : 1950)

Greenberg ZJ,Monlish DA,Bartnett RL,Yang Y,Shen G,Li W,Bednarski JJ,Schuettpelz LG

Wed Jan 01 00:00:00 EST 2020

Fibrinogen Is a Specific Trigger for Cytolytic Eosinophil Degranulation.

Journal of immunology (Baltimore, Md. : 1950)

Coden ME,Loffredo LF,Walker MT,Jeong BM,Nam K,Bochner BS,Abdala-Valencia H,Berdnikovs S

250-03 was used in Sample Preparation (FC/FACS) to show that fibrinogen is a specific trigger for cytolytic eosinophil degranulation with implications in human disease.

Wed Jan 15 00:00:00 EST 2020

Fibrinogen Is a Specific Trigger for Cytolytic Eosinophil Degranulation.

Journal of immunology (Baltimore, Md. : 1950)

Coden ME,Loffredo LF,Walker MT,Jeong BM,Nam K,Bochner BS,Abdala-Valencia H,Berdnikovs S

250-03 was used in Sample Preparation (FC/FACS) to show that fibrinogen is a specific trigger for cytolytic eosinophil degranulation with implications in human disease.

Wed Jan 15 00:00:00 EST 2020

Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation.

Journal of immunology (Baltimore, Md. : 1950)

Yoshida K,Ito MA,Sato N,Obayashi K,Yamamoto K,Koizumi S,Tanaka S,Furuta K,Matsuoka I

Mon Jun 15 00:00:00 EDT 2020

Deletion of Nemo-like Kinase in T Cells Reduces Single-Positive CD8⁺ Thymocyte Population.

Journal of immunology (Baltimore, Md. : 1950)

Daams R,Sime W,Leandersson K,Sitnicka E,Massoumi R

Thu Oct 01 00:00:00 EDT 2020

Lentiviral gene therapy rescues p47^phox chronic granulomatous disease and the ability to fight Salmonella infection in mice.

Gene therapy

Schejtman A,Aragão-Filho WC,Clare S,Zinicola M,Weisser M,Burns SO,Booth C,Gaspar HB,Thomas DC,Condino-Neto A,Thrasher AJ,Santilli G

Tue Sep 01 00:00:00 EDT 2020

Connecting secretome to hematopoietic stem cell phenotype shifts in an engineered bone marrow niche.

Integrative biology : quantitative biosciences from nano to macro

Gilchrist AE,Harley BAC

250-03 was used in Cell Culture to investigate the mechanism of how marrow-derived mesenchymal stromal and progenitor cells impacts hematopoietic stem cells fate decisions.

Fri Jul 10 00:00:00 EDT 2020

Eosinophils improve cardiac function after myocardial infarction.

Nature communications

Liu J,Yang C,Liu T,Deng Z,Fang W,Zhang X,Li J,Huang Q,Liu C,Wang Y,Yang D,Sukhova GK,Lindholt JS,Diederichsen A,Rasmussen LM,Li D,Newton G,Luscinskas FW,Liu L,Libby P,Wang J,Guo J,Shi GP

Wed Dec 16 00:00:00 EST 2020

Cyclosporine H Improves the Multi-Vector Lentiviral Transduction of Murine Haematopoietic Progenitors and Stem Cells.

Scientific reports

Olender L,Bujanover N,Sharabi O,Goldstein O,Gazit R

Tue Feb 04 00:00:00 EST 2020

GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis.

Nature communications

Regan-Komito D,Swann JW,Demetriou P,Cohen ES,Horwood NJ,Sansom SN,Griseri T

Thu Jan 09 00:00:00 EST 2020

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.

Nature communications

Leonards K,Almosailleakh M,Tauchmann S,Bagger FO,Thirant C,Juge S,Bock T,Méreau H,Bezerra MF,Tzankov A,Ivanek R,Losson R,Peters AHFM,Mercher T,Schwaller J

Fri Jun 12 00:00:00 EDT 2020

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.

Nature communications

Leonards K,Almosailleakh M,Tauchmann S,Bagger FO,Thirant C,Juge S,Bock T,Méreau H,Bezerra MF,Tzankov A,Ivanek R,Losson R,Peters AHFM,Mercher T,Schwaller J

Fri Jun 12 00:00:00 EDT 2020

Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.

Nature communications

Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ

250-03 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.

Fri Dec 04 00:00:00 EST 2020

IL-33 reduces tumor growth in models of colorectal cancer with the help of eosinophils.

Oncoimmunology

Kienzl M,Hasenoehrl C,Valadez-Cosmes P,Maitz K,Sarsembayeva A,Sturm E,Heinemann A,Kargl J,Schicho R

250-03 was used in Sample Preparation (FC/FACS) to emphasize the potential use of IL-33 as an adjuvants in CRC immunotherapy.

Tue Jun 16 00:00:00 EDT 2020

Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.

Science advances

Pessoa Rodrigues C,Herman JS,Herquel B,Valsecchi CIK,Stehle T,Grün D,Akhtar A

250-03 was used in In vitro experiments to study the mechanism by which histone H4 lysine 16 acetyltransferase MOF regulates erythropoiesis.

Fri May 01 00:00:00 EDT 2020

Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation.

FASEB bioAdvances

Aki A,Tanaka K,Nagaoka N,Kimura T,Baba D,Onodera Y,Wada T,Maeda H,Nakanishi T,Agatsuma T,Komai T

Sat Aug 01 00:00:00 EDT 2020

c-FLIP is crucial for IL-7/IL-15-dependent NKp46⁺ ILC development and protection from intestinal inflammation in mice.

Nature communications

Bank U,Deiser K,Plaza-Sirvent C,Osbelt L,Witte A,Knop L,Labrenz R,Jänsch R,Richter F,Biswas A,Zenclussen AC,Vivier E,Romagnani C,Kühl AA,Dunay IR,Strowig T,Schmitz I,Schüler T

Wed Feb 26 00:00:00 EST 2020

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML.

Nature communications

Basilico S,Wang X,Kennedy A,Tzelepis K,Giotopoulos G,Kinston SJ,Quiros PM,Wong K,Adams DJ,Carnevalli LS,Huntly BJP,Vassiliou GS,Calero-Nieto FJ,Göttgens B

Mon Mar 16 00:00:00 EDT 2020

Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.

Nature communications

Zhang Y,Guo Y,Gough SM,Zhang J,Vann KR,Li K,Cai L,Shi X,Aplan PD,Wang GG,Kutateladze TG

Fri Jul 03 00:00:00 EDT 2020

An Extended Culture System that Supports Human Primordial Germ Cell-like Cell Survival and Initiation of DNA Methylation Erasure.

Stem cell reports

Gell JJ,Liu W,Sosa E,Chialastri A,Hancock G,Tao Y,Wamaitha SE,Bower G,Dey SS,Clark AT

Tue Mar 10 00:00:00 EDT 2020

BECN1 modulates hematopoietic stem cells by targeting Caspase-3-GSDME-mediated pyroptosis.

Blood science (Baltimore, Md.)

Yang X,Ge L,Wang J

250-03 was used in Cell Culture to investigate the role of Becn1 in hematopoietic stem cells.

Wed Jul 01 00:00:00 EDT 2020

Eosinophil accumulation in postnatal lung is specific to the primary septation phase of development.

Scientific reports

Loffredo LF,Coden ME,Jeong BM,Walker MT,Anekalla KR,Doan TC,Rodriguez R,Browning M,Nam K,Lee JJ,Abdala-Valencia H,Berdnikovs S

Tue Mar 10 00:00:00 EDT 2020

MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia.

Nature communications

Itskovich SS,Gurunathan A,Clark J,Burwinkel M,Wunderlich M,Berger MR,Kulkarni A,Chetal K,Venkatasubramanian M,Salomonis N,Kumar AR,Lee LH

Tue May 12 00:00:00 EDT 2020

Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage.

Communications biology

AhYoung AP,Eckard SC,Gogineni A,Xi H,Lin SJ,Gerhardy S,Cox C,Phung QT,Hackney JA,Katakam AK,Reichelt M,Caplazi P,Manzanillo P,Zhang J,Roose-Girma M,Tam LW,Newman RJ,Murthy A,Weimer RM,Lill JR,Lee WP,Grimbaldeston M,Kirchhofer D,van Lookeren Campagne M

Thu Nov 19 00:00:00 EST 2020

Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.

Nature communications

Oatley M,Bölükbası ÖV,Svensson V,Shvartsman M,Ganter K,Zirngibl K,Pavlovich PV,Milchevskaya V,Foteva V,Natarajan KN,Baying B,Benes V,Patil KR,Teichmann SA,Lancrin C

Wed Jan 29 00:00:00 EST 2020

Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.

Nature communications

Oatley M,Bölükbası ÖV,Svensson V,Shvartsman M,Ganter K,Zirngibl K,Pavlovich PV,Milchevskaya V,Foteva V,Natarajan KN,Baying B,Benes V,Patil KR,Teichmann SA,Lancrin C

Wed Jan 29 00:00:00 EST 2020

TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis.

Cell reports

Niederkorn M,Hueneman K,Choi K,Varney ME,Romano L,Pujato MA,Greis KD,Inoue JI,Meetei R,Starczynowski DT

250-03 was used in Cell Culture to study how forkhead-associated domain B (TIFAB) regulates ubiquitin-specific peptidase 15 (USP15) ubiquitin hydrolase activity using a combination of proteomic and genetic approaches to uncover a function of TIFAB as an effector of USP15 activity and rheostat of p53 signaling in stressed and malignant hematopoietic stem/progenitor cells (HSPCs).

Tue Feb 25 00:00:00 EST 2020

In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells.

Cell reports

Montel-Hagen A,Sun V,Casero D,Tsai S,Zampieri A,Jackson N,Li S,Lopez S,Zhu Y,Chick B,He C,de Barros SC,Seet CS,Crooks GM

250-03 was used in Cell Culture to conclude that M-ATOs represent a highly reproducible and efficient experimental platform for the interrogation of clonal thymopoiesis from HSCs.

Tue Oct 27 00:00:00 EDT 2020

In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells.

Cell reports

Montel-Hagen A,Sun V,Casero D,Tsai S,Zampieri A,Jackson N,Li S,Lopez S,Zhu Y,Chick B,He C,de Barros SC,Seet CS,Crooks GM

250-03 was used in Cell Culture to conclude that M-ATOs represent a highly reproducible and efficient experimental platform for the interrogation of clonal thymopoiesis from HSCs.

Tue Oct 27 00:00:00 EDT 2020

Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species.

Science advances

Kong H,Reczek CR,McElroy GS,Steinert EM,Wang T,Sabatini DM,Chandel NS

250-03 was used in Cell Culture to demonstrate that mitochondrial complex I is a dominant metabolic determinant of mROS-dependent cellular fitness, using mitochondria-targeted antioxidants (MVE or MitoTEMPO) to pharmcologically inhibit mitochondrial complex I.

Sun Nov 01 00:00:00 EDT 2020

Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V.

Nature communications

Rai S,Tanaka H,Suzuki M,Espinoza JL,Kumode T,Tanimura A,Yokota T,Oritani K,Watanabe T,Kanakura Y,Matsumura I

Tue Aug 18 00:00:00 EDT 2020

Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.

Immunity

Tyrkalska SD,Pérez-Oliva AB,Rodríguez-Ruiz L,Martínez-Morcillo FJ,Alcaraz-Pérez F,Martínez-Navarro FJ,Lachaud C,Ahmed N,Schroeder T,Pardo-Sánchez I,Candel S,López-Muñoz A,Choudhuri A,Rossmann MP,Zon LI,Cayuela ML,García-Moreno D,Mulero V

Tue Jul 16 00:00:00 EDT 2019

Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells.

Immunity

Mariani SA,Li Z,Rice S,Krieg C,Fragkogianni S,Robinson M,Vink CS,Pollard JW,Dzierzak E

Tue Jun 18 00:00:00 EDT 2019

Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch.

Immunity

Meixiong J,Anderson M,Limjunyawong N,Sabbagh MF,Hu E,Mack MR,Oetjen LK,Wang F,Kim BS,Dong X

Tue May 21 00:00:00 EDT 2019

Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection.

Immunity

Grassmann S,Pachmayr LO,Leube J,Mihatsch L,Andrae I,Flommersfeld S,Oduro J,Cicin-Sain L,Schiemann M,Flossdorf M,Buchholz VR

Tue Jun 18 00:00:00 EDT 2019

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Cancer cell

Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG

Mon Apr 15 00:00:00 EDT 2019

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Cancer cell

Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG

Mon Apr 15 00:00:00 EDT 2019

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.

Cancer cell

Labuhn M,Perkins K,Matzk S,Varghese L,Garnett C,Papaemmanuil E,Metzner M,Kennedy A,Amstislavskiy V,Risch T,Bhayadia R,Samulowski D,Hernandez DC,Stoilova B,Iotchkova V,Oppermann U,Scheer C,Yoshida K,Schwarzer A,Taub JW,Crispino JD,Weiss MJ,Hayashi Y,Taga T,Ito E,Ogawa S,Reinhardt D,Yaspo ML,Campbell PJ,Roberts I,Constantinescu SN,Vyas P,Heckl D,Klusmann JH

Mon Aug 12 00:00:00 EDT 2019

γ-Catenin-Dependent Signals Maintain BCR-ABL1⁺ B Cell Acute Lymphoblastic Leukemia.

Cancer cell

Luong-Gardiol N,Siddiqui I,Pizzitola I,Jeevan-Raj B,Charmoy M,Huang Y,Irmisch A,Curtet S,Angelov GS,Danilo M,Juilland M,Bornhauser B,Thome M,Hantschel O,Chalandon Y,Cazzaniga G,Bourquin JP,Huelsken J,Held W

Mon Apr 15 00:00:00 EDT 2019

Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice.

Nature immunology

Piliponsky AM,Shubin NJ,Lahiri AK,Truong P,Clauson M,Niino K,Tsuha AL,Nedospasov SA,Karasuyama H,Reber LL,Tsai M,Mukai K,Galli SJ

250-03 was used in Flow cytometry/Cell sorting to demonstrate that basophil-deficient mice exhibit reduced bacterial clearance and increased morbidity and mortality in the cecal ligation and puncture (CLP) model of sepsis.

Fri Feb 01 00:00:00 EST 2019

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.

Blood

McRae HM,Garnham AL,Hu Y,Witkowski MT,Corbett MA,Dixon MP,May RE,Sheikh BN,Chiang W,Kueh AJ,Nguyen TA,Man K,Gloury R,Aubrey BJ,Policheni A,Di Rago L,Alexander WS,Gray DHD,Strasser A,Hawkins ED,Wilcox S,Gécz J,Kallies A,McCormack MP,Smyth GK,Voss AK,Thomas T

Thu Apr 18 00:00:00 EDT 2019

Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program.

Blood

Mack EA,Stein SJ,Rome KS,Xu L,Wertheim GB,Melo RCN,Pear WS

Thu May 30 00:00:00 EDT 2019

A role for macrophages in hematopoiesis in the embryonic head.

Blood

Li Z,Mariani SA,Rodriguez-Seoane C,He W,Ning X,Liu B,Vink CS,Dzierzak E

Thu Nov 28 00:00:00 EST 2019

Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment.

Blood

Abdul-Aziz AM,Sun Y,Hellmich C,Marlein CR,Mistry J,Forde E,Piddock RE,Shafat MS,Morfakis A,Mehta T,Di Palma F,Macaulay I,Ingham CJ,Haestier A,Collins A,Campisi J,Bowles KM,Rushworth SA

Thu Jan 31 00:00:00 EST 2019

Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases.

Blood

Ramasz B,Krüger A,Reinhardt J,Sinha A,Gerlach M,Gerbaulet A,Reinhardt S,Dahl A,Chavakis T,Wielockx B,Grinenko T

Thu Sep 26 00:00:00 EDT 2019

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies.

Blood

Sasca D,Yun H,Giotopoulos G,Szybinski J,Evan T,Wilson NK,Gerstung M,Gallipoli P,Green AR,Hills R,Russell N,Osborne CS,Papaemmanuil E,Göttgens B,Campbell P,Huntly BJP

Thu Dec 12 00:00:00 EST 2019

IL-7R is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemia.

Blood

González-García S,Mosquera M,Fuentes P,Palumbo T,Escudero A,Pérez-Martínez A,Ramírez M,Corcoran AE,Toribio ML

Thu Dec 12 00:00:00 EST 2019

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.

Cell stem cell

Yamashita M,Passegué E

250-03 was used in Cell Culture to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.

Thu Sep 05 00:00:00 EDT 2019

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging.

Cell stem cell

Ho YH,Del Toro R,Rivera-Torres J,Rak J,Korn C,García-García A,Macías D,González-Gómez C,Del Monte A,Wittner M,Waller AK,Foster HR,López-Otín C,Johnson RS,Nerlov C,Ghevaert C,Vainchenker W,Louache F,Andrés V,Méndez-Ferrer S

250-03 was used in Cell Culture to show that the bone marrow microenvironment promotes myelopoiesis in premature/physiological aging.

Thu Sep 05 00:00:00 EDT 2019

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.

The Journal of experimental medicine

Chen Z,Amro EM,Becker F,Hölzer M,Rasa SMM,Njeru SN,Han B,Di Sanzo S,Chen Y,Tang D,Tao S,Haenold R,Groth M,Romanov VS,Kirkpatrick JM,Kraus JM,Kestler HA,Marz M,Ori A,Neri F,Morita Y,Rudolph KL

Mon Jan 07 00:00:00 EST 2019

CD97 is a critical regulator of acute myeloid leukemia stem cell function.

The Journal of experimental medicine

Martin GH,Roy N,Chakraborty S,Desrichard A,Chung SS,Woolthuis CM,Hu W,Berezniuk I,Garrett-Bakelman FE,Hamann J,Devlin SM,Chan TA,Park CY

Mon Oct 07 00:00:00 EDT 2019

Impaired human hematopoiesis due to a cryptic intronic GATA1 splicing mutation.

The Journal of experimental medicine

Abdulhay NJ,Fiorini C,Verboon JM,Ludwig LS,Ulirsch JC,Zieger B,Lareau CA,Mi X,Roy A,Obeng EA,Erlacher M,Gupta N,Gabriel SB,Ebert BL,Niemeyer CM,Khoriaty RN,Ancliff P,Gazda HT,Wlodarski MW,Sankaran VG

Mon May 06 00:00:00 EDT 2019

Self-reactive CD4⁺ IL-3⁺ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis.

The Journal of experimental medicine

Anzai A,Mindur JE,Halle L,Sano S,Choi JL,He S,McAlpine CS,Chan CT,Kahles F,Valet C,Fenn AM,Nairz M,Rattik S,Iwamoto Y,Fairweather D,Walsh K,Libby P,Nahrendorf M,Swirski FK

Mon Feb 04 00:00:00 EST 2019

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.

The Journal of experimental medicine

Basheer F,Giotopoulos G,Meduri E,Yun H,Mazan M,Sasca D,Gallipoli P,Marando L,Gozdecka M,Asby R,Sheppard O,Dudek M,Bullinger L,Döhner H,Dillon R,Freeman S,Ottmann O,Burnett A,Russell N,Papaemmanuil E,Hills R,Campbell P,Vassiliou GS,Huntly BJP

Mon Apr 01 00:00:00 EDT 2019

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.

The Journal of experimental medicine

Mon Apr 01 00:00:00 EDT 2019

TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone.

The Journal of experimental medicine

Albright AR,Kabat J,Li M,Raso F,Reboldi A,Muppidi JR

Mon Nov 04 00:00:00 EST 2019

Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity.

The Journal of allergy and clinical immunology

Klein O,Krier-Burris RA,Lazki-Hagenbach P,Gorzalczany Y,Mei Y,Ji P,Bochner BS,Sagi-Eisenberg R

250-03 was used in Cell Culture to identify mDia1 as a novel regulator of MC response that coordinates MC chemotaxis and secretion through its actin-nucleating activity.

Tue Oct 01 00:00:00 EDT 2019

The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.

The EMBO journal

Sainz de Aja J,Menchero S,Rollan I,Barral A,Tiana M,Jawaid W,Cossio I,Alvarez A,Carreño-Tarragona G,Badia-Careaga C,Nichols J,Göttgens B,Isern J,Manzanares M

Mon Apr 01 00:00:00 EDT 2019

Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.

Cell systems

Zhou W,Yui MA,Williams BA,Yun J,Wold BJ,Cai L,Rothenberg EV

250-03 was used in Cell Culture to imply that multilineage priming is integral to T cell specification.

Wed Oct 23 00:00:00 EDT 2019

Role of CXCR2 in the Ac-PGP-Induced Mobilization of Circulating Angiogenic Cells and its Therapeutic Implications.

Stem cells translational medicine

Kwon YW,Lee SJ,Heo SC,Lee TW,Park GT,Yoon JW,Kim SC,Shin HJ,Lee SC,Kim JH

Fri Mar 01 00:00:00 EST 2019

Putative Role of Nuclear Factor-Kappa B But Not Hypoxia-Inducible Factor-1α in Hypoxia-Dependent Regulation of Oxidative Stress in Hematopoietic Stem and Progenitor Cells.

Antioxidants & redox signaling

Halvarsson C,Rörby E,Eliasson P,Lang S,Soneji S,Jönsson JI

250-03 was used in Cell Culture to investigate if HIF-1α protects hematopoietic stem cells against ROS.

Sat Jul 20 00:00:00 EDT 2019

Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia.

Cancer science

Chu Y,Chen Y,Li M,Shi D,Wang B,Lian Y,Cheng X,Wang X,Xu M,Cheng T,Shi J,Yuan W

Mon Jul 01 00:00:00 EDT 2019

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3.

Immunology and cell biology

McCarthy PC,Phair IR,Greger C,Pardali K,McGuire VA,Clark AR,Gaestel M,Arthur JSC

Tue Jan 01 00:00:00 EST 2019

Mast cell tetrahydrobiopterin contributes to itch in mice.

Journal of cellular and molecular medicine

Zschiebsch K,Fischer C,Wilken-Schmitz A,Geisslinger G,Channon K,Watschinger K,Tegeder I

Fri Feb 01 00:00:00 EST 2019

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.

Cell reports

Luo H,Mu WC,Karki R,Chiang HH,Mohrin M,Shin JJ,Ohkubo R,Ito K,Kanneganti TD,Chen D

250-03 was used in Cell Culture to assess whether the NLRP3 inflammasome is aberrantly activated in haematopoietic stem cells during physiological ageing.

Tue Jan 22 00:00:00 EST 2019

Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease.

Frontiers in immunology

Strattan E,Palaniyandi S,Kumari R,Du J,Hakim N,Huang T,Kesler MV,Jennings CD,Sturgill JL,Hildebrandt GC

250-03 was used in In vitro experiments to show for the first time a role for mast cells in skin chronic graft-vs-host disease that may be targetable for preventive and therapeutic intervention in this disease.

Tue Nov 17 00:00:00 EST 2020

The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.

Nature communications

Nayak RC,Hegde S,Althoff MJ,Wellendorf AM,Mohmoud F,Perentesis J,Reina-Campos M,Reynaud D,Zheng Y,Diaz-Meco MT,Moscat J,Cancelas JA

Fri Jan 04 00:00:00 EST 2019

Docosahexaenoyl ethanolamide mitigates IgE-mediated allergic reactions by inhibiting mast cell degranulation and regulating allergy-related immune cells.

Scientific reports

Nishi K,Kanayama Y,Kim IH,Nakata A,Nishiwaki H,Sugahara T

Thu Nov 07 00:00:00 EST 2019

Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development.

Cell death & disease

Gong Z,Shang B,Chu Y,Chen X,Li Q,Liu K,Chen Y,Huang Y,Han Y,Shang Q,Zheng Z,Song L,Li Y,Liu R,Xu C,Zhang X,Liu B,Wang L,Shao C,Wang Y,Shi Y

Wed Jun 05 00:00:00 EDT 2019

All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.

Cell death & disease

Nguyen CH,Bauer K,Hackl H,Schlerka A,Koller E,Hladik A,Stoiber D,Zuber J,Staber PB,Hoelbl-Kovacic A,Purton LE,Grebien F,Wieser R

Tue Dec 10 00:00:00 EST 2019

Functional Oocytes Derived from Granulosa Cells.

Cell reports

Tian C,Liu L,Ye X,Fu H,Sheng X,Wang L,Wang H,Heng D,Liu L

250-03 was used in Cell Culture to demonstrate that funtional oocytes posessing high genomic stability can be produced in vitro from somatic gPSCs through cellular reprogramming, facilitated by protonic sodium or acid - overall a safe and effective chemical induction technique.

Tue Dec 24 00:00:00 EST 2019

Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome.

Cell stem cell

Masiuk KE,Laborada J,Roncarolo MG,Hollis RP,Kohn DB

250-03 was used in Cell Culture to demonstrate preclinical efficacy for the treatment of IPEX patients by autologous HSC transplant and may provide valuable insights into new cell therapies for autoimmunity.

Thu Feb 07 00:00:00 EST 2019

Gfi1-Mediated Repression of c-Fos, Egr-1 and Egr-2, and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis.

Scientific reports

Zhang Y,Hu N,Dong F

Thu Jan 24 00:00:00 EST 2019

Avenanthramide C from germinated oats exhibits anti-allergic inflammatory effects in mast cells.

Scientific reports

Dhakal H,Yang EJ,Lee S,Kim MJ,Baek MC,Lee B,Park PH,Kwon TK,Khang D,Song KS,Kim SH

Fri May 03 00:00:00 EDT 2019

Non-thermal plasma inhibits mast cell activation and ameliorates allergic skin inflammatory diseases in NC/Nga mice.

Scientific reports

Lee MH,Lee YS,Kim HJ,Han CH,Kang SU,Kim CH

Wed Sep 18 00:00:00 EDT 2019

The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.

Nature communications

Papaioannou D,Petri A,Dovey OM,Terreri S,Wang E,Collins FA,Woodward LA,Walker AE,Nicolet D,Pepe F,Kumchala P,Bill M,Walker CJ,Karunasiri M,Mrózek K,Gardner ML,Camilotto V,Zitzer N,Cooper JL,Cai X,Rong-Mullins X,Kohlschmidt J,Archer KJ,Freitas MA,Zheng Y,Lee RJ,Aifantis I,Vassiliou G,Singh G,Kauppinen S,Bloomfield CD,Dorrance AM,Garzon R

Mon Nov 25 00:00:00 EST 2019

Resveratrol inhibits IL-33-mediated mast cell activation by targeting the MK2/3-PI3K/Akt axis.

Scientific reports

Nakajima S,Ishimaru K,Kobayashi A,Yu G,Nakamura Y,Oh-Oka K,Suzuki-Inoue K,Kono K,Nakao A

Thu Dec 05 00:00:00 EST 2019

Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.

Nature communications

Wang Y,Lu T,Sun G,Zheng Y,Yang S,Zhang H,Hao S,Liu Y,Ma S,Zhang H,Ru Y,Gao S,Yen K,Cheng H,Cheng T

Fri Dec 06 00:00:00 EST 2019

Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells.

Scientific reports

Nakamura Y,Sasaki T,Mochizuki C,Ishimaru K,Koizumi S,Shinmori H,Suzuki-Inoue K,Nakao A

Mon Nov 04 00:00:00 EST 2019

Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis.

Scientific reports

Lin CH,Wang Z,Duque-Afonso J,Wong SH,Demeter J,Loktev AV,Somervaille TCP,Jackson PK,Cleary ML

Wed Mar 20 00:00:00 EDT 2019

IL1RL1 is dynamically expressed on Cbfb-MYH11⁺ leukemia stem cells and promotes cell survival.

Scientific reports

Wang Y,Richter L,Becker M,Amador C,Hyde RK

Mon Feb 11 00:00:00 EST 2019

Anti-inflammatory and vasculogenic conditioning of peripheral blood mononuclear cells reinforces their therapeutic potential for radiation-injured salivary glands.

Stem cell research & therapy

I T,Sumita Y,Yoshida T,Honma R,Iwatake M,Raudales JLM,Shizuno T,Kuroshima S,Masuda H,Seki M,Tran SD,Asahara T,Asahina I

250-03 was used in Cell Culture to investigate methods conditioning peripheral blood mononuclear cells to regenerate salivary gland following head and neck cancer treatment.

Thu Oct 17 00:00:00 EDT 2019

Population snapshots predict early haematopoietic and erythroid hierarchies.

Nature

Tusi BK,Wolock SL,Weinreb C,Hwang Y,Hidalgo D,Zilionis R,Waisman A,Huh JR,Klein AM,Socolovsky M

Thu Mar 01 00:00:00 EST 2018

Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation.

Nature

Shen Q,Zhang Q,Shi Y,Shi Q,Jiang Y,Gu Y,Li Z,Li X,Zhao K,Wang C,Li N,Cao X

Thu Feb 01 00:00:00 EST 2018

Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells.

Nature

Carrelha J,Meng Y,Kettyle LM,Luis TC,Norfo R,Alcolea V,Boukarabila H,Grasso F,Gambardella A,Grover A,Högstrand K,Lord AM,Sanjuan-Pla A,Woll PS,Nerlov C,Jacobsen SEW

Thu Feb 01 00:00:00 EST 2018

Senescence-associated reprogramming promotes cancer stemness.

Nature

Milanovic M,Fan DNY,Belenki D,Däbritz JHM,Zhao Z,Yu Y,Dörr JR,Dimitrova L,Lenze D,Monteiro Barbosa IA,Mendoza-Parra MA,Kanashova T,Metzner M,Pardon K,Reimann M,Trumpp A,Dörken B,Zuber J,Gronemeyer H,Hummel M,Dittmar G,Lee S,Schmitt CA

Thu Jan 04 00:00:00 EST 2018

Clonal analysis of lineage fate in native haematopoiesis.

Nature

Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD

Thu Jan 11 00:00:00 EST 2018

Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.

Nature biotechnology

Kosicki M,Tomberg K,Bradley A

Sat Sep 01 00:00:00 EDT 2018

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Cell

Mitroulis I,Ruppova K,Wang B,Chen LS,Grzybek M,Grinenko T,Eugster A,Troullinaki M,Palladini A,Kourtzelis I,Chatzigeorgiou A,Schlitzer A,Beyer M,Joosten LAB,Isermann B,Lesche M,Petzold A,Simons K,Henry I,Dahl A,Schultze JL,Wielockx B,Zamboni N,Mirtschink P,Coskun Ü,Hajishengallis G,Netea MG,Chavakis T

Thu Jan 11 00:00:00 EST 2018

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.

Cell

Pulikkan JA,Hegde M,Ahmad HM,Belaghzal H,Illendula A,Yu J,O'Hagan K,Ou J,Muller-Tidow C,Wolfe SA,Zhu LJ,Dekker J,Bushweller JH,Castilla LH

250-03 was used in In vitro experiments to study the mechanism for the ways in which CBFβ-SMMHC drives leukemia maintenance and show that inhibitors targeting chromatin activity may prove effective in inv(16) leukemia therapy.

Thu Jun 28 00:00:00 EDT 2018

Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.

Cell

Minzel W,Venkatachalam A,Fink A,Hung E,Brachya G,Burstain I,Shaham M,Rivlin A,Omer I,Zinger A,Elias S,Winter E,Erdman PE,Sullivan RW,Fung L,Mercurio F,Li D,Vacca J,Kaushansky N,Shlush L,Oren M,Levine R,Pikarsky E,Snir-Alkalay I,Ben-Neriah Y

Thu Sep 20 00:00:00 EDT 2018

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies.

Cell

Xiao G,Chan LN,Klemm L,Braas D,Chen Z,Geng H,Zhang QC,Aghajanirefah A,Cosgun KN,Sadras T,Lee J,Mirzapoiazova T,Salgia R,Ernst T,Hochhaus A,Jumaa H,Jiang X,Weinstock DM,Graeber TG,Müschen M

Thu Apr 05 00:00:00 EDT 2018

T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.

Immunity

Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W

Tue Apr 17 00:00:00 EDT 2018

A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses.

Immunity

Postat J,Olekhnovitch R,Lemaître F,Bousso P

Tue Oct 16 00:00:00 EDT 2018

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.

Immunity

Hosokawa H,Ungerbäck J,Wang X,Matsumoto M,Nakayama KI,Cohen SM,Tanaka T,Rothenberg EV

Tue Jun 19 00:00:00 EDT 2018

The Majority of CD45^- Ter119^- CD31^- Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors.

Immunity

Boulais PE,Mizoguchi T,Zimmerman S,Nakahara F,Vivié J,Mar JC,van Oudenaarden A,Frenette PS

Tue Oct 16 00:00:00 EDT 2018

A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.

Immunity

Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z

Tue Apr 17 00:00:00 EDT 2018

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors.

Immunity

Li Z,Liu S,Xu J,Zhang X,Han D,Liu J,Xia M,Yi L,Shen Q,Xu S,Lu L,Cao X

Tue Oct 16 00:00:00 EDT 2018

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.

Cancer cell

Maes T,Mascaró C,Tirapu I,Estiarte A,Ciceri F,Lunardi S,Guibourt N,Perdones A,Lufino MMP,Somervaille TCP,Wiseman DH,Duy C,Melnick A,Willekens C,Ortega A,Martinell M,Valls N,Kurz G,Fyfe M,Castro-Palomino JC,Buesa C

Mon Mar 12 00:00:00 EDT 2018

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

Cancer cell

Yamauchi T,Masuda T,Canver MC,Seiler M,Semba Y,Shboul M,Al-Raqad M,Maeda M,Schoonenberg VAC,Cole MA,Macias-Trevino C,Ishikawa Y,Yao Q,Nakano M,Arai F,Orkin SH,Reversade B,Buonamici S,Pinello L,Akashi K,Bauer DE,Maeda T

Mon Mar 12 00:00:00 EDT 2018

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.

Cancer cell

Kunimoto H,Meydan C,Nazir A,Whitfield J,Shank K,Rapaport F,Maher R,Pronier E,Meyer SC,Garrett-Bakelman FE,Tallman M,Melnick A,Levine RL,Shih AH

Mon Jan 08 00:00:00 EST 2018

Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.

Cancer cell

Vanden Bempt M,Demeyer S,Broux M,De Bie J,Bornschein S,Mentens N,Vandepoel R,Geerdens E,Radaelli E,Bornhauser BC,Kulozik AE,Meijerink JP,Bourquin JP,de Bock CE,Cools J

Mon Aug 13 00:00:00 EDT 2018

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Cancer cell

Booth CAG,Barkas N,Neo WH,Boukarabila H,Soilleux EJ,Giotopoulos G,Farnoud N,Giustacchini A,Ashley N,Carrelha J,Jamieson L,Atkinson D,Bouriez-Jones T,Prinjha RK,Milne TA,Teachey DT,Papaemmanuil E,Huntly BJP,Jacobsen SEW,Mead AJ

Mon Feb 12 00:00:00 EST 2018

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.

Cancer cell

Kleppe M,Koche R,Zou L,van Galen P,Hill CE,Dong L,De Groote S,Papalexi E,Hanasoge Somasundara AV,Cordner K,Keller M,Farnoud N,Medina J,McGovern E,Reyes J,Roberts J,Witkin M,Rapaport F,Teruya-Feldstein J,Qi J,Rampal R,Bernstein BE,Bradner JE,Levine RL

Mon Jan 08 00:00:00 EST 2018

Crbn ^I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice.

Blood

Fink EC,McConkey M,Adams DN,Haldar SD,Kennedy JA,Guirguis AA,Udeshi ND,Mani DR,Chen M,Liddicoat B,Svinkina T,Nguyen AT,Carr SA,Ebert BL

Thu Oct 04 00:00:00 EDT 2018

Glutaminolysis is a metabolic dependency in FLT3^ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.

Blood

Gallipoli P,Giotopoulos G,Tzelepis K,Costa ASH,Vohra S,Medina-Perez P,Basheer F,Marando L,Di Lisio L,Dias JML,Yun H,Sasca D,Horton SJ,Vassiliou G,Frezza C,Huntly BJP

Thu Apr 12 00:00:00 EDT 2018

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice.

Blood

Dahlin JS,Hamey FK,Pijuan-Sala B,Shepherd M,Lau WWY,Nestorowa S,Weinreb C,Wolock S,Hannah R,Diamanti E,Kent DG,Göttgens B,Wilson NK

Thu May 24 00:00:00 EDT 2018

Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells.

Blood

Shima H,Takamatsu-Ichihara E,Shino M,Yamagata K,Katsumoto T,Aikawa Y,Fujita S,Koseki H,Kitabayashi I

Thu Apr 19 00:00:00 EDT 2018

Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation.

Blood

Jacquelin S,Straube J,Cooper L,Vu T,Song A,Bywater M,Baxter E,Heidecker M,Wackrow B,Porter A,Ling V,Green J,Austin R,Kazakoff S,Waddell N,Hesson LB,Pimanda JE,Stegelmann F,Bullinger L,Döhner K,Rampal RK,Heckl D,Hill GR,Lane SW

Thu Dec 27 00:00:00 EST 2018

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.

Blood

El Ashkar S,Schwaller J,Pieters T,Goossens S,Demeulemeester J,Christ F,Van Belle S,Juge S,Boeckx N,Engelman A,Van Vlierberghe P,Debyser Z,De Rijck J

Thu Jan 04 00:00:00 EST 2018

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML.

Cell stem cell

Duarte D,Hawkins ED,Akinduro O,Ang H,De Filippo K,Kong IY,Haltalli M,Ruivo N,Straszkowski L,Vervoort SJ,McLean C,Weber TS,Khorshed R,Pirillo C,Wei A,Ramasamy SK,Kusumbe AP,Duffy K,Adams RH,Purton LE,Carlin LM,Lo Celso C

250-03 was used in Cell Culture to suggest that preventing degradation of the endosteal vasculature may improve current paradigms for treating acute myeloid leukemia.

Thu Jan 04 00:00:00 EST 2018

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.

The Journal of clinical investigation

Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P

Tue Jan 02 00:00:00 EST 2018

JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling.

The Journal of clinical investigation

Zhang Y,Xia F,Liu X,Yu Z,Xie L,Liu L,Chen C,Jiang H,Hao X,He X,Zhang F,Gu H,Zhu J,Bai H,Zhang CC,Chen GQ,Zheng J

Tue May 01 00:00:00 EDT 2018

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.

The Journal of clinical investigation

Zhang P,He F,Bai J,Yamamoto S,Chen S,Zhang L,Sheng M,Zhang L,Guo Y,Man N,Yang H,Wang S,Cheng T,Nimer SD,Zhou Y,Xu M,Wang QF,Yang FC

Mon Dec 03 00:00:00 EST 2018

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.

The Journal of clinical investigation

Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML

Fri Jun 01 00:00:00 EDT 2018

Kinetics of adult hematopoietic stem cell differentiation in vivo.

The Journal of experimental medicine

Upadhaya S,Sawai CM,Papalexi E,Rashidfarrokhi A,Jang G,Chattopadhyay P,Satija R,Reizis B

Mon Nov 05 00:00:00 EST 2018

Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response.

The Journal of experimental medicine

Barbieri D,Elvira-Matelot E,Pelinski Y,Genève L,de Laval B,Yogarajah G,Pecquet C,Constantinescu SN,Porteu F

Mon May 07 00:00:00 EDT 2018

Altered compensatory cytokine signaling underlies the discrepancy between and mice.

The Journal of experimental medicine

Durai V,Bagadia P,Briseño CG,Theisen DJ,Iwata A,Davidson JT,Gargaro M,Fremont DH,Murphy TL,Murphy KM

Mon May 07 00:00:00 EDT 2018

Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.

The Journal of experimental medicine

Tober J,Maijenburg MMW,Li Y,Gao L,Hadland BK,Gao P,Minoura K,Bernstein ID,Tan K,Speck NA

Mon Feb 05 00:00:00 EST 2018

Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.

The Journal of experimental medicine

Jensen CT,Åhsberg J,Sommarin MNE,Strid T,Somasundaram R,Okuyama K,Ungerbäck J,Kupari J,Airaksinen MS,Lang S,Bryder D,Soneji S,Karlsson G,Sigvardsson M

Mon Jul 02 00:00:00 EDT 2018

Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation.

The Journal of experimental medicine

Arnold IC,Artola-Borán M,Tallón de Lara P,Kyburz A,Taube C,Ottemann K,van den Broek M,Yousefi S,Simon HU,Müller A

Mon Aug 06 00:00:00 EDT 2018

Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.

The Journal of experimental medicine

Khalil S,Delehanty L,Grado S,Holy M,White Z,Freeman K,Kurita R,Nakamura Y,Bullock G,Goldfarb A

Mon Feb 05 00:00:00 EST 2018

The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.

The Journal of allergy and clinical immunology

Li Y,Liu B,Harmacek L,Long Z,Liang J,Lukin K,Leach SM,O'Connor B,Gerber AN,Hagman J,Roers A,Finkelman FD,Huang H

250-03 was used in Cell Culture to conclude that the transcription factors GATA2 and MITF regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.

Mon Oct 01 00:00:00 EDT 2018

Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia.

Leukemia

Mingay M,Chaturvedi A,Bilenky M,Cao Q,Jackson L,Hui T,Moksa M,Heravi-Moussavi A,Humphries RK,Heuser M,Hirst M

Mon Jan 01 00:00:00 EST 2018

Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches.

Proceedings of the National Academy of Sciences of the United States of America

Das P,Veazey KJ,Van HT,Kaushik S,Lin K,Lu Y,Ishii M,Kikuta J,Ge K,Nussenzweig A,Santos MA

Tue Oct 23 00:00:00 EDT 2018

Revealing nascent proteomics in signaling pathways and cell differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Forester CM,Zhao Q,Phillips NJ,Urisman A,Chalkley RJ,Oses-Prieto JA,Zhang L,Ruggero D,Burlingame AL

Tue Mar 06 00:00:00 EST 2018

Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.

Proceedings of the National Academy of Sciences of the United States of America

Sharma S,Čermáková K,De Rijck J,Demeulemeester J,Fábry M,El Ashkar S,Van Belle S,Lepšík M,Tesina P,Duchoslav V,Novák P,Hubálek M,Srb P,Christ F,Řezáčová P,Hodges HC,Debyser Z,Veverka V

Tue Jul 24 00:00:00 EDT 2018

Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells.

Oncogene

Pinazza M,Ghisi M,Minuzzo S,Agnusdei V,Fossati G,Ciminale V,Pezzè L,Ciribilli Y,Pilotto G,Venturoli C,Amadori A,Indraccolo S

Sun Jul 01 00:00:00 EDT 2018

TLR-7 Stress Signaling in Differentiating and Mature Eosinophils Is Mediated by the Prolyl Isomerase Pin1.

Journal of immunology (Baltimore, Md. : 1950)

Shen ZJ,Hu J,Kashi V,Bochkov YA,Gern JE,Malter JS

Sat Dec 15 00:00:00 EST 2018

Talin1 Methylation Is Required for Neutrophil Infiltration and Lipopolysaccharide-Induced Lethality.

Journal of immunology (Baltimore, Md. : 1950)

Lim TJF,Su IH

Sat Dec 15 00:00:00 EST 2018

Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1.

Journal of immunology (Baltimore, Md. : 1950)

Mumau MD,Vanderbeck AN,Lynch ED,Golec SB,Emerson SG,Punt JA

Thu Feb 01 00:00:00 EST 2018

Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.

Journal of immunology (Baltimore, Md. : 1950)

Kostrzewski T,Borg AJ,Meng Y,Filipovic I,Male V,Wack A,DiMaggio PA,Brady HJM

Thu Feb 15 00:00:00 EST 2018

Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.

Cell stem cell

Qian P,De Kumar B,He XC,Nolte C,Gogol M,Ahn Y,Chen S,Li Z,Xu H,Perry JM,Hu D,Tao F,Zhao M,Han Y,Hall K,Peak A,Paulson A,Zhao C,Venkatraman A,Box A,Perera A,Haug JS,Parmely T,Li H,Krumlauf R,Li L

250-03 was used in Cell Culture to demonstrate roles for retinoid signaling and the DERARE in maintaining HSCs and preventing leukemogenesis by coordinate regulation of Hoxb genes.

Thu May 03 00:00:00 EDT 2018

ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity.

Nature communications

Massara M,Bonavita O,Savino B,Caronni N,Mollica Poeta V,Sironi M,Setten E,Recordati C,Crisafulli L,Ficara F,Mantovani A,Locati M,Bonecchi R

Wed Feb 14 00:00:00 EST 2018

Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse.

Scientific reports

Philp AR,Riquelme TT,Millar-Büchner P,González R,Sepúlveda FV,Cid LP,Flores CA

Mon Jun 18 00:00:00 EDT 2018

Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation.

Nature immunology

Cuartero S,Weiss FD,Dharmalingam G,Guo Y,Ing-Simmons E,Masella S,Robles-Rebollo I,Xiao X,Wang YF,Barozzi I,Djeghloul D,Amano MT,Niskanen H,Petretto E,Dowell RD,Tachibana K,Kaikkonen MU,Nasmyth KA,Lenhard B,Natoli G,Fisher AG,Merkenschlager M

250-03 was used in Cell Culture to show that cohesin is required for the core transcriptional response of primary macrophages to microbial signals, and for inducible enhancer activity that underpins inflammatory gene expression.

Sat Sep 01 00:00:00 EDT 2018

GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice.

Scientific reports

Chen C,Li X,Ge G,Liu J,Biju KC,Laing SD,Qian Y,Ballard C,He Z,Masliah E,Clark RA,O'Connor JC,Li S

Tue Apr 03 00:00:00 EDT 2018

Deficiency in Fpr2 results in reduced numbers of Lin^-cKit⁺Sca1⁺ myeloid progenitor cells.

The Journal of biological chemistry

Chen K,Tang P,Bao Z,He T,Xiang Y,Gong W,Yoshimura T,Le Y,Tessarollo L,Chen X,Wang JM

Fri Aug 31 00:00:00 EDT 2018

MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia.

Cell death & disease

Hartmann JU,Bräuer-Hartmann D,Kardosova M,Wurm AA,Wilke F,Schödel C,Gerloff D,Katzerke C,Krakowsky R,Namasu CY,Bill M,Schwind S,Müller-Tidow C,Niederwieser D,Alberich-Jorda M,Behre G

Thu Jul 26 00:00:00 EDT 2018

Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling.

Cell reports

Schmitt M,Schewe M,Sacchetti A,Feijtel D,van de Geer WS,Teeuwssen M,Sleddens HF,Joosten R,van Royen ME,van de Werken HJG,van Es J,Clevers H,Fodde R

250-03 was used in Cell Culture to show that acute inflammation of the mouse small intestine is followed by a dramatic loss of Lgr5+ stem cells.

Tue Aug 28 00:00:00 EDT 2018

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.

Nature communications

Grinenko T,Eugster A,Thielecke L,Ramasz B,Krüger A,Dietz S,Glauche I,Gerbaulet A,von Bonin M,Basak O,Clevers H,Chavakis T,Wielockx B

Tue May 15 00:00:00 EDT 2018

The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells.

Cell death & disease

Liu T,Kong WX,Tang XY,Xu M,Wang QH,Zhang B,Hu LD,Chen H

Thu Jun 07 00:00:00 EDT 2018

iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice.

Stem cell reports

Mucci A,Lopez-Rodriguez E,Hetzel M,Liu S,Suzuki T,Happle C,Ackermann M,Kempf H,Hillje R,Kunkiel J,Janosz E,Brennig S,Glage S,Bankstahl JP,Dettmer S,Rodt T,Gohring G,Trapnell B,Hansen G,Trapnell C,Knudsen L,Lachmann N,Moritz T

Tue Sep 11 00:00:00 EDT 2018

In Vitro Differentiation of Gata2 and Ly6a Reporter Embryonic Stem Cells Corresponds to In Vivo Waves of Hematopoietic Cell Generation.

Stem cell reports

Kauts ML,Rodriguez-Seoane C,Kaimakis P,Mendes SC,Cortés-Lavaud X,Hill U,Dzierzak E

Tue Jan 09 00:00:00 EST 2018

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim.

Nature communications

Hu P,Nebreda AR,Hanenberg H,Kinnebrew GH,Ivan M,Yoder MC,Filippi MD,Broxmeyer HE,Kapur R

Wed Aug 29 00:00:00 EDT 2018

Honokiol is a FOXM1 antagonist.

Cell death & disease

Halasi M,Hitchinson B,Shah BN,Váraljai R,Khan I,Benevolenskaya EV,Gaponenko V,Arbiser JL,Gartel AL

Wed Jan 24 00:00:00 EST 2018

Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.

Cell stem cell

Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP

250-03 was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.

Thu Nov 01 00:00:00 EDT 2018

Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.

Cell stem cell

Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP

250-03 was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.

Thu Nov 01 00:00:00 EDT 2018

Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow.

Stem cell reports

Karatepe K,Zhu H,Zhang X,Guo R,Kambara H,Loison F,Liu P,Yu H,Ren Q,Luo X,Manis J,Cheng T,Ma F,Xu Y,Luo HR

Tue Nov 13 00:00:00 EST 2018

Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression.

Nature communications

Calcinotto A,Brevi A,Chesi M,Ferrarese R,Garcia Perez L,Grioni M,Kumar S,Garbitt VM,Sharik ME,Henderson KJ,Tonon G,Tomura M,Miwa Y,Esplugues E,Flavell RA,Huber S,Canducci F,Rajkumar VS,Bergsagel PL,Bellone M

Mon Dec 03 00:00:00 EST 2018

SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival.

Nature communications

Su H,Hu J,Huang L,Yang Y,Thenoz M,Kuchmiy A,Hu Y,Li P,Feng H,Zhou Y,Taghon T,Van Vlierberghe P,Qing G,Chen Z,Liu H

Mon Oct 15 00:00:00 EDT 2018

mTOR complexes differentially orchestrates eosinophil development in allergy.

Scientific reports

Zhu C,Xia L,Li F,Zhou L,Weng Q,Li Z,Wu Y,Mao Y,Zhang C,Wu Y,Li M,Ying S,Chen Z,Shen H,Li W

Wed May 02 00:00:00 EDT 2018

Biological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume).

Scientific reports

Kono R,Nakamura M,Nomura S,Kitano N,Kagiya T,Okuno Y,Inada KI,Tokuda A,Utsunomiya H,Ueno M

Fri Aug 03 00:00:00 EDT 2018

Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs.

Nature communications

Ganuza M,Chabot A,Tang X,Bi W,Natarajan S,Carter R,Gawad C,Kang G,Cheng Y,McKinney-Freeman S

Thu Dec 20 00:00:00 EST 2018

Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis.

Cell discovery

Rothberg JLM,Maganti HB,Jrade H,Porter CJ,Palidwor GA,Cafariello C,Battaion HL,Khan ST,Perkins TJ,Paulson RF,Ito CY,Stanford WL

Thu Aug 17 00:00:00 EDT 2023

Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.

Nature communications

Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM

Tue Jan 02 00:00:00 EST 2018

A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions.

Nature communications

Brown JM,Roberts NA,Graham B,Waithe D,Lagerholm C,Telenius JM,De Ornellas S,Oudelaar AM,Scott C,Szczerbal I,Babbs C,Kassouf MT,Hughes JR,Higgs DR,Buckle VJ

Fri Sep 21 00:00:00 EDT 2018

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.

Nature communications

Numata A,Kwok HS,Kawasaki A,Li J,Zhou QL,Kerry J,Benoukraf T,Bararia D,Li F,Ballabio E,Tapia M,Deshpande AJ,Welner RS,Delwel R,Yang H,Milne TA,Taneja R,Tenen DG

Tue Apr 24 00:00:00 EDT 2018

Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach.

Stem cell reports

Senserrich J,Batsivari A,Rybtsov S,Gordon-Keylock S,Souilhol C,Buchholz F,Hills D,Zhao S,Medvinsky A

Tue Sep 11 00:00:00 EDT 2018

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.

Nature communications

Hyrenius-Wittsten A,Pilheden M,Sturesson H,Hansson J,Walsh MP,Song G,Kazi JU,Liu J,Ramakrishan R,Garcia-Ruiz C,Nance S,Gupta P,Zhang J,Rönnstrand L,Hultquist A,Downing JR,Lindkvist-Petersson K,Paulsson K,Järås M,Gruber TA,Ma J,Hagström-Andersson AK

Wed May 02 00:00:00 EDT 2018

Embryonic germ cell extracts erase imprinted genes and improve the efficiency of induced pluripotent stem cells.

Scientific reports

Hu J,Zhao Q,Feng Y,Li N,Gu Y,Sun R,Duan L,Wu Y,Shan Z,Lei L

Thu Jul 19 00:00:00 EDT 2018

Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice.

Communications biology

Willetts L,Felix LC,Jacobsen EA,Puttagunta L,Condjella RM,Zellner KR,Ochkur SI,Kim JD,Luo H,Lee NA,Lee JJ,Moqbel R,Lacy P

Sat Jan 11 00:00:00 EST 2020

Generation of BMEC Lines and in vitro BMEC-HSPC Co-culture Assays.

Bio-protocol

Guo P,Rafii S

250-03 was used in Cell Culture to show that the BMEC-HSPC co-culture system serves as bioreactor prototype to generate scalable populations of the blood and immune systems.

Mon Nov 05 00:00:00 EST 2018

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.

Stem cell reports

Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E

Tue Oct 09 00:00:00 EDT 2018

Elevated Oxidative Stress Impairs Hematopoietic Progenitor Function in C57BL/6 Substrains.

Stem cell reports

Morales-Hernández A,Martinat A,Chabot A,Kang G,McKinney-Freeman S

Tue Aug 14 00:00:00 EDT 2018

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.

Nature communications

Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K

Tue Dec 11 00:00:00 EST 2018

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.

Nature communications

Tzelepis K,De Braekeleer E,Aspris D,Barbieri I,Vijayabaskar MS,Liu WH,Gozdecka M,Metzakopian E,Toop HD,Dudek M,Robson SC,Hermida-Prado F,Yang YH,Babaei-Jadidi R,Garyfallos DA,Ponstingl H,Dias JML,Gallipoli P,Seiler M,Buonamici S,Vick B,Bannister AJ,Rad R,Prinjha RK,Marioni JC,Huntly B,Batson J,Morris JC,Pina C,Bradley A,Jeremias I,Bates DO,Yusa K,Kouzarides T,Vassiliou GS

Wed Dec 19 00:00:00 EST 2018

Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation.

Cell reports

Nakamura-Ishizu A,Matsumura T,Stumpf PS,Umemoto T,Takizawa H,Takihara Y,O'Neil A,Majeed ABBA,MacArthur BD,Suda T

250-03 was used in Cell Culture to report an important role for thrombopoietin in regulating rapid megakaryocyte-lineage commitment.

Tue Nov 13 00:00:00 EST 2018

In vitro improvement of quail primordial germ cell expansion through activation of TGF-beta signaling pathway.

Journal of cellular biochemistry

Yakhkeshi S,Rahimi S,Sharafi M,Hassani SN,Taleahmad S,Shahverdi A,Baharvand H

250-03 was used in In vitro experiments to suggest that the application of IDE1 small molecule into the culture of quail PGCs represented a step toward achieving efficient expansion of the avian PGCs.

Fri Jun 01 00:00:00 EDT 2018

Promoter-bound METTL3 maintains myeloid leukaemia by m⁶A-dependent translation control.

Nature

Barbieri I,Tzelepis K,Pandolfini L,Shi J,Millán-Zambrano G,Robson SC,Aspris D,Migliori V,Bannister AJ,Han N,De Braekeleer E,Ponstingl H,Hendrick A,Vakoc CR,Vassiliou GS,Kouzarides T

Thu Dec 07 00:00:00 EST 2017

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.

Cell

Burgess MR,Hwang E,Mroue R,Bielski CM,Wandler AM,Huang BJ,Firestone AJ,Young A,Lacap JA,Crocker L,Asthana S,Davis EM,Xu J,Akagi K,Le Beau MM,Li Q,Haley B,Stokoe D,Sampath D,Taylor BS,Evangelista M,Shannon K

Thu Feb 23 00:00:00 EST 2017

Plexin-B2 Mediates Physiologic and Pathologic Functions of Angiogenin.

Cell

Yu W,Goncalves KA,Li S,Kishikawa H,Sun G,Yang H,Vanli N,Wu Y,Jiang Y,Hu MG,Friedel RH,Hu GF

Thu Nov 02 00:00:00 EDT 2017

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.

Cell

Cimmino L,Dolgalev I,Wang Y,Yoshimi A,Martin GH,Wang J,Ng V,Xia B,Witkowski MT,Mitchell-Flack M,Grillo I,Bakogianni S,Ndiaye-Lobry D,Martín MT,Guillamot M,Banh RS,Xu M,Figueroa ME,Dickins RA,Abdel-Wahab O,Park CY,Tsirigos A,Neel BG,Aifantis I

Thu Sep 07 00:00:00 EDT 2017

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.

Cell

Cabezas-Wallscheid N,Buettner F,Sommerkamp P,Klimmeck D,Ladel L,Thalheimer FB,Pastor-Flores D,Roma LP,Renders S,Zeisberger P,Przybylla A,Schönberger K,Scognamiglio R,Altamura S,Florian CM,Fawaz M,Vonficht D,Tesio M,Collier P,Pavlinic D,Geiger H,Schroeder T,Benes V,Dick TP,Rieger MA,Stegle O,Trumpp A

Thu May 18 00:00:00 EDT 2017

Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.

Immunity

Fu B,Zhou Y,Ni X,Tong X,Xu X,Dong Z,Sun R,Tian Z,Wei H

250-03 was used in In vitro experiments to reveal properties of Natural Killer (NK) cells in promoting fetal growth.

Tue Dec 19 00:00:00 EST 2017

The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.

Immunity

Miyazaki M,Miyazaki K,Chen K,Jin Y,Turner J,Moore AJ,Saito R,Yoshida K,Ogawa S,Rodewald HR,Lin YC,Kawamoto H,Murre C

Tue May 16 00:00:00 EDT 2017

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

Cancer cell

Chen Y,Anastassiadis K,Kranz A,Stewart AF,Arndt K,Waskow C,Yokoyama A,Jones K,Neff T,Lee Y,Ernst P

Mon Jun 12 00:00:00 EDT 2017

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Cancer cell

Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C,Kuchenbauer F,Schütz E,Green AR,Urlaub H,Stegmaier K,Humphries RK,Serve H,Oellerich T

Mon Apr 10 00:00:00 EDT 2017

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Cancer cell

Mon Apr 10 00:00:00 EDT 2017

CSF-1-induced Src signaling can instruct monocytic lineage choice.

Blood

Endele M,Loeffler D,Kokkaliaris KD,Hilsenbeck O,Skylaki S,Hoppe PS,Schambach A,Stanley ER,Schroeder T

Thu Mar 23 00:00:00 EDT 2017

FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.

Blood

Ishizawa J,Sugihara E,Kuninaka S,Mogushi K,Kojima K,Benton CB,Zhao R,Chachad D,Hashimoto N,Jacamo RO,Qiu Y,Yoo SY,Okamoto S,Andreeff M,Kornblau SM,Saya H

Thu Apr 06 00:00:00 EDT 2017

Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner.

Blood

Man N,Tan Y,Sun XJ,Liu F,Cheng G,Greenblatt SM,Martinez C,Karl DL,Ando K,Sun M,Hou D,Chen B,Xu M,Yang FC,Chen Z,Chen S,Nimer SD,Wang L

Thu May 18 00:00:00 EDT 2017

NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival.

Blood

Prince LR,Prosseda SD,Higgins K,Carlring J,Prestwich EC,Ogryzko NV,Rahman A,Basran A,Falciani F,Taylor P,Renshaw SA,Whyte MKB,Sabroe I

Thu Aug 24 00:00:00 EDT 2017

Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.

Blood

Dovey OM,Cooper JL,Mupo A,Grove CS,Lynn C,Conte N,Andrews RM,Pacharne S,Tzelepis K,Vijayabaskar MS,Green P,Rad R,Arends M,Wright P,Yusa K,Bradley A,Varela I,Vassiliou GS

Thu Oct 26 00:00:00 EDT 2017

Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression.

The Journal of clinical investigation

Guo P,Poulos MG,Palikuqi B,Badwe CR,Lis R,Kunar B,Ding BS,Rabbany SY,Shido K,Butler JM,Rafii S

Fri Dec 01 00:00:00 EST 2017

Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche.

The Journal of clinical investigation

Mitroulis I,Chen LS,Singh RP,Kourtzelis I,Economopoulou M,Kajikawa T,Troullinaki M,Ziogas A,Ruppova K,Hosur K,Maekawa T,Wang B,Subramanian P,Tonn T,Verginis P,von Bonin M,Wobus M,Bornhäuser M,Grinenko T,Di Scala M,Hidalgo A,Wielockx B,Hajishengallis G,Chavakis T

Mon Oct 02 00:00:00 EDT 2017

Histamine-releasing factor enhances food allergy.

The Journal of clinical investigation

Ando T,Kashiwakura JI,Itoh-Nagato N,Yamashita H,Baba M,Kawakami Y,Tsai SH,Inagaki N,Takeda K,Iwata T,Shimojo N,Fujisawa T,Nagao M,Matsumoto K,Kawakami Y,Kawakami T

Fri Dec 01 00:00:00 EST 2017

Endothelial transplantation rejuvenates aged hematopoietic stem cell function.

The Journal of clinical investigation

Poulos MG,Ramalingam P,Gutkin MC,Llanos P,Gilleran K,Rabbany SY,Butler JM

Wed Nov 01 00:00:00 EDT 2017

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.

Molecular cell

Jaco I,Annibaldi A,Lalaoui N,Wilson R,Tenev T,Laurien L,Kim C,Jamal K,Wicky John S,Liccardi G,Chau D,Murphy JM,Brumatti G,Feltham R,Pasparakis M,Silke J,Meier P

250-03 was used in Cell Culture to study how TNF induced activation of MK2 results in global RIPK1 phosphorylation which serves as a checkpoint within the TNF signaling pathway which integrates cell survival and cytokine production.

Thu Jun 01 00:00:00 EDT 2017

Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies.

The Journal of experimental medicine

Tanaka T,Nakajima-Takagi Y,Aoyama K,Tara S,Oshima M,Saraya A,Koide S,Si S,Manabe I,Sanada M,Nakayama M,Masuko M,Sone H,Koseki H,Iwama A

Mon Oct 02 00:00:00 EDT 2017

Mast cells acquire MHCII from dendritic cells during skin inflammation.

The Journal of experimental medicine

Dudeck J,Medyukhina A,Fröbel J,Svensson CM,Kotrba J,Gerlach M,Gradtke AC,Schröder B,Speier S,Figge MT,Dudeck A

Mon Dec 04 00:00:00 EST 2017

TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.

The Journal of experimental medicine

Schweighoffer E,Nys J,Vanes L,Smithers N,Tybulewicz VLJ

Mon May 01 00:00:00 EDT 2017

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.

The Journal of experimental medicine

Wiede F,Dudakov JA,Lu KH,Dodd GT,Butt T,Godfrey DI,Strasser A,Boyd RL,Tiganis T

Mon Sep 04 00:00:00 EDT 2017

Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease.

The Journal of experimental medicine

Uderhardt S,Ackermann JA,Fillep T,Hammond VJ,Willeit J,Santer P,Mayr M,Biburger M,Miller M,Zellner KR,Stark K,Zarbock A,Rossaint J,Schubert I,Mielenz D,Dietel B,Raaz-Schrauder D,Ay C,Gremmel T,Thaler J,Heim C,Herrmann M,Collins PW,Schabbauer G,Mackman N,Voehringer D,Nadler JL,Lee JJ,Massberg S,Rauh M,Kiechl S,Schett G,O'Donnell VB,Krönke G

Mon Jul 03 00:00:00 EDT 2017

A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.

The Journal of experimental medicine

McGarvey AC,Rybtsov S,Souilhol C,Tamagno S,Rice R,Hills D,Godwin D,Rice D,Tomlinson SR,Medvinsky A

Mon Dec 04 00:00:00 EST 2017

Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.

Autophagy

Chen X,Clark J,Wunderlich M,Fan C,Davis A,Chen S,Guan JL,Mulloy JC,Kumar A,Zheng Y

250-03 was used in Cell Culture to uncover anti-leukemic effects of choloroquine being independent of autophagy which can be enhanced via vesicular exocytotis inhibition, and autophagy being an insignificant target of MA9-AML therapy.

Thu May 04 00:00:00 EDT 2017

Transplantation of iPS-Derived Tumor Cells with a Homozygous MHC Haplotype Induces GRP94 Antibody Production in MHC-Matched Macaques.

Cancer research

Ishigaki H,Maeda T,Inoue H,Akagi T,Sasamura T,Ishida H,Inubushi T,Okahara J,Shiina T,Nakayama M,Itoh Y,Ogasawara K

250-03 was used in Cell Culture to demonstrate that autoantibodies can mitigate tumour growth in vitro and in vivo.

Wed Nov 01 00:00:00 EDT 2017

Preclinical modeling of myelodysplastic syndromes.

Leukemia

Rouault-Pierre K,Mian SA,Goulard M,Abarrategi A,Di Tulio A,Smith AE,Mohamedali A,Best S,Nloga AM,Kulasekararaj AG,Ades L,Chomienne C,Fenaux P,Dosquet C,Mufti GJ,Bonnet D

Fri Dec 01 00:00:00 EST 2017

Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Gao X,Lee HY,Li W,Platt RJ,Barrasa MI,Ma Q,Elmes RR,Rosenfeld MG,Lodish HF

Tue Sep 19 00:00:00 EDT 2017

Eosinophils subvert host resistance to an intracellular pathogen by instigating non-protective IL-4 in CCR2^-/- mice.

Mucosal immunology

Verma AH,Bueter CL,Rothenberg ME,Deepe GS

Sun Jan 01 00:00:00 EST 2017

α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds.

Journal of immunology (Baltimore, Md. : 1950)

Falahee PC,Anderson LS,Reynolds MB,Pirir M,McLaughlin BE,Dillen CA,Cheung AL,Miller LS,Simon SI

Fri Sep 01 00:00:00 EDT 2017

Macrophage-Specific Expression of IL-37 in Hyperlipidemic Mice Attenuates Atherosclerosis.

Journal of immunology (Baltimore, Md. : 1950)

McCurdy S,Baumer Y,Toulmin E,Lee BH,Boisvert WA

Wed Nov 15 00:00:00 EST 2017

The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis.

Journal of immunology (Baltimore, Md. : 1950)

Drube S,Grimlowski R,Deppermann C,Fröbel J,Kraft F,Andreas N,Stegner D,Dudeck J,Weber F,Rödiger M,Göpfert C,Drube J,Reich D,Nieswandt B,Dudeck A,Kamradt T

Sun Oct 15 00:00:00 EDT 2017

The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production.

Journal of immunology (Baltimore, Md. : 1950)

Netherby CS,Messmer MN,Burkard-Mandel L,Colligan S,Miller A,Cortes Gomez E,Wang J,Nemeth MJ,Abrams SI

Mon May 15 00:00:00 EDT 2017

Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors.

Journal of immunology (Baltimore, Md. : 1950)

Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Hayashi T,Nakachi K,Moore MA,van den Brink MRM,Kusunoki Y

Sun Oct 15 00:00:00 EDT 2017

TGF-β1 Suppresses IL-33-Induced Mast Cell Function.

Journal of immunology (Baltimore, Md. : 1950)

Ndaw VS,Abebayehu D,Spence AJ,Paez PA,Kolawole EM,Taruselli MT,Caslin HL,Chumanevich AP,Paranjape A,Baker B,Barnstein BO,Haque TT,Kiwanuka KN,Oskeritzian CA,Ryan JJ

Tue Aug 01 00:00:00 EDT 2017

p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation.

Nature communications

Hinge A,Xu J,Javier J,Mose E,Kumar S,Kapur R,Srour EF,Malik P,Aronow BJ,Filippi MD

Wed Feb 08 00:00:00 EST 2017

An unexpected protein interaction promotes drug resistance in leukemia.

Nature communications

Pitre A,Ge Y,Lin W,Wang Y,Fukuda Y,Temirov J,Phillips AH,Peters JL,Fan Y,Ma J,Nourse A,Sinha C,Lin H,Kriwacki R,Downing JR,Gruber TA,Centonze VE,Naren AP,Chen T,Schuetz JD

Thu Nov 16 00:00:00 EST 2017

Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice.

Molecular therapy. Methods & clinical development

Lee S,Kivimäe S,Szoka FC

250-03 was used in In vitro experiments to generate Hoxb8-dependent myeloid progenitors (HDPs) by transducing lineage-negative bone marrow cells with a constitutively expressed Hoxb8 flanked by loxP. HDPs proliferate indefinitely and differentiate into MΦ when Hoxb8 is removed by a tamoxifen-inducible Cre.

Fri Dec 15 00:00:00 EST 2017

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.

Scientific reports

Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T

Fri Sep 29 00:00:00 EDT 2017

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.

Nature communications

Yu M,Chen Y,Zeng H,Zheng Y,Fu G,Zhu W,Broeckel U,Aggarwal P,Turner A,Neale G,Guy C,Zhu N,Chi H,Wen R,Wang D

Mon Nov 13 00:00:00 EST 2017

Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.

The Journal of biological chemistry

Nadeau SA,An W,Mohapatra BC,Mushtaq I,Bielecki TA,Luan H,Zutshi N,Ahmad G,Storck MD,Sanada M,Ogawa S,Band V,Band H

Fri Mar 03 00:00:00 EST 2017

Murine Retrovirally-Transduced Bone Marrow Engraftment Models of MLL-Fusion-Driven Acute Myelogenous Leukemias (AML).

Current protocols in pharmacology

Stubbs MC,Krivtsov AV

250-03 was used in In vitro experiments to define protocols which focus on bone marrow-derived models only, using one particular MLL fusion, MLL-AF9.

Mon Sep 11 00:00:00 EDT 2017

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.

Nature communications

Ranjan S,Goihl A,Kohli S,Gadi I,Pierau M,Shahzad K,Gupta D,Bock F,Wang H,Shaikh H,Kähne T,Reinhold D,Bank U,Zenclussen AC,Niemz J,Schnöder TM,Brunner-Weinzierl M,Fischer T,Kalinski T,Schraven B,Luft T,Huehn J,Naumann M,Heidel FH,Isermann B

Mon Aug 21 00:00:00 EDT 2017

IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development.

Nature communications

Liu B,Ye B,Zhu X,Huang G,Yang L,Zhu P,Du Y,Wu J,Meng S,Tian Y,Fan Z

Thu Aug 10 00:00:00 EDT 2017

CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production.

Scientific reports

Rozenberg P,Reichman H,Zab-Bar I,Itan M,Pasmanik-Chor M,Bouffi C,Qimron U,Bachelet I,Fulkerson PC,Rothenberg ME,Munitz A

Wed Jul 19 00:00:00 EDT 2017

Role of Mast Cells in clearance of Leishmania through extracellular trap formation.

Scientific reports

Naqvi N,Ahuja K,Selvapandiyan A,Dey R,Nakhasi H,Puri N

Mon Oct 16 00:00:00 EDT 2017

Role of Mast Cells in clearance of Leishmania through extracellular trap formation.

Scientific reports

Naqvi N,Ahuja K,Selvapandiyan A,Dey R,Nakhasi H,Puri N

Mon Oct 16 00:00:00 EDT 2017

TC-PTP regulates the IL-7 transcriptional response during murine early T cell development.

Scientific reports

Pike KA,Hatzihristidis T,Bussières-Marmen S,Robert F,Desai N,Miranda-Saavedra D,Pelletier J,Tremblay ML

Mon Oct 16 00:00:00 EDT 2017

IL-7 and immobilized Kit-ligand stimulate serum- and stromal cell-free cultures of precursor B-cell lines and clones.

European journal of immunology

Kawano Y,Petkau G,Wolf I,Tornack J,Melchers F

250-03 was used in Cell Culture to describe a novel serum-free, stromal cell-free culture system, which allows us to establish and maintain pre-B cells not only from fetal liver, but also from bone marrow with practically identical efficiencies in proliferation, cloning and differentiation.

Sun Jan 01 00:00:00 EST 2017

Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.

Nature biotechnology

Stevens MM,Maire CL,Chou N,Murakami MA,Knoff DS,Kikuchi Y,Kimmerling RJ,Liu H,Haidar S,Calistri NL,Cermak N,Olcum S,Cordero NA,Idbaih A,Wen PY,Weinstock DM,Ligon KL,Manalis SR

250-03 was used in In vitro experiments to investigate assays for tumour cell therapeutic response.

Tue Nov 01 00:00:00 EDT 2016

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.

Cell

Puram RV,Kowalczyk MS,de Boer CG,Schneider RK,Miller PG,McConkey M,Tothova Z,Tejero H,Heckl D,Järås M,Chen MC,Li H,Tamayo A,Cowley GS,Rozenblatt-Rosen O,Al-Shahrour F,Regev A,Ebert BL

Thu Apr 07 00:00:00 EDT 2016

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq.

Cell

Jaitin DA,Weiner A,Yofe I,Lara-Astiaso D,Keren-Shaul H,David E,Salame TM,Tanay A,van Oudenaarden A,Amit I

Thu Dec 15 00:00:00 EST 2016

Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.

Immunity

Kristiansen TA,Jaensson Gyllenbäck E,Zriwil A,Björklund T,Daniel JA,Sitnicka E,Soneji S,Bryder D,Yuan J

Tue Aug 16 00:00:00 EDT 2016

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

Cell metabolism

Kishton RJ,Barnes CE,Nichols AG,Cohen S,Gerriets VA,Siska PJ,Macintyre AN,Goraksha-Hicks P,de Cubas AA,Liu T,Warmoes MO,Abel ED,Yeoh AE,Gershon TR,Rathmell WK,Richards KL,Locasale JW,Rathmell JC

250-03 was used in Cell Culture to study to what extent the leukemic T cell populations are metabolically similar and if differences reveal T cell acute lymphoblastic leukemia (T-ALL) vulnerabilities.

Tue Apr 12 00:00:00 EDT 2016

Identification of factors promoting ex vivo maintenance of mouse hematopoietic stem cells by long-term single-cell quantification.

Blood

Kokkaliaris KD,Drew E,Endele M,Loeffler D,Hoppe PS,Hilsenbeck O,Schauberger B,Hinzen C,Skylaki S,Theodorou M,Kieslinger M,Lemischka I,Moore K,Schroeder T

Thu Sep 01 00:00:00 EDT 2016

EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation.

Blood

Gnanapragasam MN,McGrath KE,Catherman S,Xue L,Palis J,Bieker JJ

Thu Sep 22 00:00:00 EDT 2016

Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.

Blood

Schulze I,Rohde C,Scheller-Wendorff M,Bäumer N,Krause A,Herbst F,Riemke P,Hebestreit K,Tschanter P,Lin Q,Linhart H,Godley LA,Glimm H,Dugas M,Wagner W,Berdel WE,Rosenbauer F,Müller-Tidow C

Thu Mar 24 00:00:00 EDT 2016

Developing HSCs become Notch independent by the end of maturation in the AGM region.

Blood

Souilhol C,Lendinez JG,Rybtsov S,Murphy F,Wilson H,Hills D,Batsivari A,Binagui-Casas A,McGarvey AC,MacDonald HR,Kageyama R,Siebel C,Zhao S,Medvinsky A

Thu Sep 22 00:00:00 EDT 2016

MicroRNA-139-5p regulates proliferation of hematopoietic progenitors and is repressed during BCR-ABL-mediated leukemogenesis.

Blood

Choi J,Kim YK,Park K,Nah J,Yoon SS,Kim DW,Kim VN,Seong RH

Thu Oct 27 00:00:00 EDT 2016

MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice.

Blood

Baba T,Tanabe Y,Yoshikawa S,Yamanishi Y,Morishita S,Komatsu N,Karasuyama H,Hirao A,Mukaida N

Thu May 26 00:00:00 EDT 2016

Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells.

Blood

Dhahri D,Sato-Kusubata K,Ohki-Koizumi M,Nishida C,Tashiro Y,Munakata S,Shimazu H,Salama Y,Eiamboonsert S,Nakauchi H,Hattori K,Heissig B

Thu Aug 25 00:00:00 EDT 2016

Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells.

Blood

Dhahri D,Sato-Kusubata K,Ohki-Koizumi M,Nishida C,Tashiro Y,Munakata S,Shimazu H,Salama Y,Eiamboonsert S,Nakauchi H,Hattori K,Heissig B

Thu Aug 25 00:00:00 EDT 2016

LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.

The Journal of clinical investigation

Cheng Y,Chikwava K,Wu C,Zhang H,Bhagat A,Pei D,Choi JK,Tong W

Fri Apr 01 00:00:00 EDT 2016

FGF23 signaling impairs neutrophil recruitment and host defense during CKD.

The Journal of clinical investigation

Rossaint J,Oehmichen J,Van Aken H,Reuter S,Pavenstädt HJ,Meersch M,Unruh M,Zarbock A

Tue Mar 01 00:00:00 EST 2016

PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.

The Journal of clinical investigation

Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ

Fri Jan 01 00:00:00 EST 2016

Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.

The Journal of clinical investigation

Gu H,Chen C,Hao X,Wang C,Zhang X,Li Z,Shao H,Zeng H,Yu Z,Xie L,Xia F,Zhang F,Liu X,Zhang Y,Jiang H,Zhu J,Wan J,Wang C,Weng W,Xie J,Tao M,Zhang CC,Liu J,Chen GQ,Zheng J

Thu Dec 01 00:00:00 EST 2016

Functional screen identifies regulators of murine hematopoietic stem cell repopulation.

The Journal of experimental medicine

Holmfeldt P,Ganuza M,Marathe H,He B,Hall T,Kang G,Moen J,Pardieck J,Saulsberry AC,Cico A,Gaut L,McGoldrick D,Finkelstein D,Tan K,McKinney-Freeman S

Mon Mar 07 00:00:00 EST 2016

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.

The Journal of experimental medicine

Hatlen MA,Arora K,Vacic V,Grabowska EA,Liao W,Riley-Gillis B,Oschwald DM,Wang L,Joergens JE,Shih AH,Rapaport F,Gu S,Voza F,Asai T,Neel BG,Kharas MG,Gonen M,Levine RL,Nimer SD

Mon Jan 11 00:00:00 EST 2016

Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging.

The Journal of experimental medicine

Young K,Borikar S,Bell R,Kuffler L,Philip V,Trowbridge JJ

Mon Oct 17 00:00:00 EDT 2016

Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses.

The Journal of experimental medicine

Bannard O,McGowan SJ,Ersching J,Ishido S,Victora GD,Shin JS,Cyster JG

Mon May 30 00:00:00 EDT 2016

Targeting MTHFD2 in acute myeloid leukemia.

The Journal of experimental medicine

Pikman Y,Puissant A,Alexe G,Furman A,Chen LM,Frumm SM,Ross L,Fenouille N,Bassil CF,Lewis CA,Ramos A,Gould J,Stone RM,DeAngelo DJ,Galinsky I,Clish CB,Kung AL,Hemann MT,Vander Heiden MG,Banerji V,Stegmaier K

Mon Jun 27 00:00:00 EDT 2016

Multiple allogeneic progenitors in combination function as a unit to support early transient hematopoiesis in transplantation.

The Journal of experimental medicine

Ishida T,Takahashi S,Lai CY,Nojima M,Yamamoto R,Takeuchi E,Takeuchi Y,Higashihara M,Nakauchi H,Otsu M

Mon Aug 22 00:00:00 EDT 2016

Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis.

The Journal of experimental medicine

Shimizu T,Kubovcakova L,Nienhold R,Zmajkovic J,Meyer SC,Hao-Shen H,Geier F,Dirnhofer S,Guglielmelli P,Vannucchi AM,Feenstra JD,Kralovics R,Orkin SH,Skoda RC

Mon Jul 25 00:00:00 EDT 2016

DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.

Stem cells (Dayton, Ohio)

Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA

Tue Mar 01 00:00:00 EST 2016

DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.

Stem cells (Dayton, Ohio)

Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA

Tue Mar 01 00:00:00 EST 2016

DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.

Stem cells (Dayton, Ohio)

Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA

Tue Mar 01 00:00:00 EST 2016

DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.

Stem cells (Dayton, Ohio)

Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA

Tue Mar 01 00:00:00 EST 2016

AKT Signaling Prevailing in Mesenchymal Stromal Cells Modulates the Functionality of Hematopoietic Stem Cells via Intercellular Communication.

Stem cells (Dayton, Ohio)

Singh S,Moirangthem RD,Vaidya A,Jalnapurkar S,Limaye L,Kale V

Thu Sep 01 00:00:00 EDT 2016

CXCR4 Signaling Negatively Modulates the Bipotential State of Hemogenic Endothelial Cells Derived from Embryonic Stem Cells by Attenuating the Endothelial Potential.

Stem cells (Dayton, Ohio)

Ahmed T,Tsuji-Tamura K,Ogawa M

Thu Dec 01 00:00:00 EST 2016

SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells.

Stem cells (Dayton, Ohio)

Du W,Amarachintha S,Wilson AF,Pang Q

Fri Apr 01 00:00:00 EDT 2016

Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity.

Stem cells (Dayton, Ohio)

Frame JM,Fegan KH,Conway SJ,McGrath KE,Palis J

Mon Feb 01 00:00:00 EST 2016

MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Drube S,Kraft F,Dudeck J,Müller AL,Weber F,Göpfert C,Meininger I,Beyer M,Irmler I,Häfner N,Schütz D,Stumm R,Yakovleva T,Gaestel M,Dudeck A,Kamradt T

Tue Nov 01 00:00:00 EDT 2016

Intratumorally Establishing Type 2 Innate Lymphoid Cells Blocks Tumor Growth.

Journal of immunology (Baltimore, Md. : 1950)

Kim J,Kim W,Moon UJ,Kim HJ,Choi HJ,Sin JI,Park NH,Cho HR,Kwon B

Tue Mar 01 00:00:00 EST 2016

Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt Signaling Pathway.

Journal of immunology (Baltimore, Md. : 1950)

Sertorio M,Amarachintha S,Wilson A,Pang Q

Fri Apr 01 00:00:00 EDT 2016

Cooperative Activity of GABP with PU.1 or C/EBPε Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation.

Journal of immunology (Baltimore, Md. : 1950)

Malu K,Garhwal R,Pelletier MG,Gotur D,Halene S,Zwerger M,Yang ZF,Rosmarin AG,Gaines P

Mon Aug 01 00:00:00 EDT 2016

IL-10 Enhances IgE-Mediated Mast Cell Responses and Is Essential for the Development of Experimental Food Allergy in IL-10-Deficient Mice.

Journal of immunology (Baltimore, Md. : 1950)

Polukort SH,Rovatti J,Carlson L,Thompson C,Ser-Dolansky J,Kinney SR,Schneider SS,Mathias CB

Wed Jun 15 00:00:00 EDT 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Tue Aug 09 00:00:00 EDT 2016

Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells.

Nature communications

Souilhol C,Gonneau C,Lendinez JG,Batsivari A,Rybtsov S,Wilson H,Morgado-Palacin L,Hills D,Taoudi S,Antonchuk J,Zhao S,Medvinsky A

Tue Mar 08 00:00:00 EST 2016

Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model.

Cell death & disease

Liu Q,Chen L,Atkinson JM,Claxton DF,Wang HG

Thu Sep 08 00:00:00 EDT 2016

Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells.

Nature communications

George J,Uyar A,Young K,Kuffler L,Waldron-Francis K,Marquez E,Ucar D,Trowbridge JJ

Mon Jul 11 00:00:00 EDT 2016

Human GV oocytes generated by mitotically active germ cells obtained from follicular aspirates.

Scientific reports

Ding X,Liu G,Xu B,Wu C,Hui N,Ni X,Wang J,Du M,Teng X,Wu J

Thu Jun 30 00:00:00 EDT 2016

Human GV oocytes generated by mitotically active germ cells obtained from follicular aspirates.

Scientific reports

Ding X,Liu G,Xu B,Wu C,Hui N,Ni X,Wang J,Du M,Teng X,Wu J

Thu Jun 30 00:00:00 EDT 2016

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.

Nature communications

Ding X,Ray Chaudhuri A,Callen E,Pang Y,Biswas K,Klarmann KD,Martin BK,Burkett S,Cleveland L,Stauffer S,Sullivan T,Dewan A,Marks H,Tubbs AT,Wong N,Buehler E,Akagi K,Martin SE,Keller JR,Nussenzweig A,Sharan SK

Mon Aug 08 00:00:00 EDT 2016

Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis.

Nature communications

Poulos MG,Ramalingam P,Gutkin MC,Kleppe M,Ginsberg M,Crowley MJP,Elemento O,Levine RL,Rafii S,Kitajewski J,Greenblatt MB,Shim JH,Butler JM

Wed Dec 21 00:00:00 EST 2016

Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2.

Cell death & disease

Xia LX,Hua W,Jin Y,Tian BP,Qiu ZW,Zhang C,Che LQ,Zhou HB,Wu YF,Huang HQ,Lan F,Ke YH,Lee JJ,Li W,Ying SM,Chen ZH,Shen HH

Thu Apr 07 00:00:00 EDT 2016

Generation and Analysis of GATA2^w/eGFP Human ESCs Reveal ITGB3/CD61 as a Reliable Marker for Defining Hemogenic Endothelial Cells during Hematopoiesis.

Stem cell reports

Huang K,Gao J,Du J,Ma N,Zhu Y,Wu P,Zhang T,Wang W,Li Y,Chen Q,Hutchins AP,Yang Z,Zheng Y,Zhang J,Shan Y,Li X,Liao B,Liu J,Wang J,Liu B,Pan G

Tue Nov 08 00:00:00 EST 2016

B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia.

The Journal of biological chemistry

Imoto N,Hayakawa F,Kurahashi S,Morishita T,Kojima Y,Yasuda T,Sugimoto K,Tsuzuki S,Naoe T,Kiyoi H

Fri Feb 26 00:00:00 EST 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Thu Jun 02 00:00:00 EDT 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Thu Jun 02 00:00:00 EDT 2016

Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.

Nature communications

Lai M,Gonzalez-Martin A,Cooper AB,Oda H,Jin HY,Shepherd J,He L,Zhu J,Nemazee D,Xiao C

Tue Aug 02 00:00:00 EDT 2016

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.

Nature communications

Gamrekelashvili J,Giagnorio R,Jussofie J,Soehnlein O,Duchene J,Briseño CG,Ramasamy SK,Krishnasamy K,Limbourg A,Kapanadze T,Ishifune C,Hinkel R,Radtke F,Strobl LJ,Zimber-Strobl U,Napp LC,Bauersachs J,Haller H,Yasutomo K,Kupatt C,Murphy KM,Adams RH,Weber C,Limbourg FP

Wed Aug 31 00:00:00 EDT 2016

Chronic Myeloid Leukemia (CML) Mouse Model in Translational Research.

Methods in molecular biology (Clifton, N.J.)

Peng C,Li S

250-03 was used in Cell Culture to describe how we utilize this triple gene system to prove the function of Pten as a tumor suppressor in leukemogenesis.

Mon Dec 18 00:00:00 EST 2017

Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity.

Nature communications

Jung H,Kim DO,Byun JE,Kim WS,Kim MJ,Song HY,Kim YK,Kang DK,Park YJ,Kim TD,Yoon SR,Lee HG,Choi EJ,Min SH,Choi I

250-03 was used in Sample Preparation (FC/FACS) to study the rejuvenation of stem cells and report that the thioredoxin-interacting protein (TXNIP)-p38 mitogen-activated protein kinase (p38) axis regulates the ageing of haematopoietic stem cells (HSCs), by causing a higher frequency of long-term HSCs, lineage skewing, a decrease in engraftment, an increase in reactive oxygen species and loss of Cdc42 polarity.

Thu Dec 08 00:00:00 EST 2016

Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.

Nature communications

Gu Z,Churchman M,Roberts K,Li Y,Liu Y,Harvey RC,McCastlain K,Reshmi SC,Payne-Turner D,Iacobucci I,Shao Y,Chen IM,Valentine M,Pei D,Mungall KL,Mungall AJ,Ma Y,Moore R,Marra M,Stonerock E,Gastier-Foster JM,Devidas M,Dai Y,Wood B,Borowitz M,Larsen EE,Maloney K,Mattano LA,Angiolillo A,Salzer WL,Burke MJ,Gianni F,Spinelli O,Radich JP,Minden MD,Moorman AV,Patel B,Fielding AK,Rowe JM,Luger SM,Bhatia R,Aldoss I,Forman SJ,Kohlschmidt J,Mrózek K,Marcucci G,Bloomfield CD,Stock W,Kornblau S,Kantarjian HM,Konopleva M,Paietta E,Willman CL,Loh ML,Hunger SP,Mullighan CG

Tue Nov 08 00:00:00 EST 2016

CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress.

Scientific reports

Zhang Y,Dépond M,He L,Foudi A,Kwarteng EO,Lauret E,Plo I,Desterke C,Dessen P,Fujii N,Opolon P,Herault O,Solary E,Vainchenker W,Joulin V,Louache F,Wittner M

Fri Nov 25 00:00:00 EST 2016

Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche.

Nature communications

Hu X,Garcia M,Weng L,Jung X,Murakami JL,Kumar B,Warden CD,Todorov I,Chen CC

Mon Oct 10 00:00:00 EDT 2016

USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.

Stem cell reports

Higuchi M,Kawamura H,Matsuki H,Hara T,Takahashi M,Saito S,Saito K,Jiang S,Naito M,Kiyonari H,Fujii M

Tue Dec 13 00:00:00 EST 2016

KRAS insertion mutations are oncogenic and exhibit distinct functional properties.

Nature communications

White Y,Bagchi A,Van Ziffle J,Inguva A,Bollag G,Zhang C,Carias H,Dickens D,Loh M,Shannon K,Firestone AJ

Mon Feb 08 00:00:00 EST 2016

In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery.

Nature communications

Bahal R,Ali McNeer N,Quijano E,Liu Y,Sulkowski P,Turchick A,Lu YC,Bhunia DC,Manna A,Greiner DL,Brehm MA,Cheng CJ,López-Giráldez F,Ricciardi A,Beloor J,Krause DS,Kumar P,Gallagher PG,Braddock DT,Mark Saltzman W,Ly DH,Glazer PM

250-03 was used in Sample Preparation (FC/FACS) to demonstrate that iplex-forming peptide nucleic acids (PNAs) substituted at the γ position plus stimulation of the stem cell factor (SCF)/c-Kit pathway yields high levels of gene editing in haematopoietic stem cells (HSCs) in a mouse model of human β-thalassaemia.

Wed Oct 26 00:00:00 EDT 2016

Induction of Chronic Myeloid Leukemia in Mice.

Methods in molecular biology (Clifton, N.J.)

Zhang H,Li S

250-03 was used in In vitro experiments to describe methods for induction of CML in mice with BCR-ABL.

Fri Jan 26 00:00:00 EST 2018

Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.

Nature

Chen Z,Shojaee S,Buchner M,Geng H,Lee JW,Klemm L,Titz B,Graeber TG,Park E,Tan YX,Satterthwaite A,Paietta E,Hunger SP,Willman CL,Melnick A,Loh ML,Jung JU,Coligan JE,Bolland S,Mak TW,Limnander A,Jumaa H,Reth M,Weiss A,Lowell CA,Müschen M

Thu May 21 00:00:00 EDT 2015

IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice.

Blood

Siegemund S,Rigaud S,Conche C,Broaten B,Schaffer L,Westernberg L,Head SR,Sauer K

Thu Apr 30 00:00:00 EDT 2015

T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung.

Blood

Iriguchi S,Kikuchi N,Kaneko S,Noguchi E,Morishima Y,Matsuyama M,Yoh K,Takahashi S,Nakauchi H,Ishii Y

Thu Jan 08 00:00:00 EST 2015

Morgana acts as an oncosuppressor in chronic myeloid leukemia.

Blood

Di Savino A,Panuzzo C,Rocca S,Familiari U,Piazza R,Crivellaro S,Carrà G,Ferretti R,Fusella F,Giugliano E,Camporeale A,Franco I,Miniscalco B,Cutrin JC,Turco E,Silengo L,Hirsch E,Rege-Cambrin G,Gambacorti-Passerini C,Pandolfi PP,Papotti M,Saglio G,Tarone G,Morotti A,Brancaccio M

Thu Apr 02 00:00:00 EDT 2015

MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia.

Blood

Roychoudhury J,Clark JP,Gracia-Maldonado G,Unnisa Z,Wunderlich M,Link KA,Dasgupta N,Aronow B,Huang G,Mulloy JC,Kumar AR

Thu Apr 16 00:00:00 EDT 2015

Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.

Blood

Xiao N,Laha S,Das SP,Morlock K,Jesneck JL,Raffel GD

Thu Feb 05 00:00:00 EST 2015

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.

Blood

Shaham L,Vendramini E,Ge Y,Goren Y,Birger Y,Tijssen MR,McNulty M,Geron I,Schwartzman O,Goldberg L,Chou ST,Pitman H,Weiss MJ,Michaeli S,Sredni B,Göttgens B,Crispino JD,Taub JW,Izraeli S

Thu Feb 19 00:00:00 EST 2015

Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.

The Journal of clinical investigation

Park SM,Gönen M,Vu L,Minuesa G,Tivnan P,Barlowe TS,Taggart J,Lu Y,Deering RP,Hacohen N,Figueroa ME,Paietta E,Fernandez HF,Tallman MS,Melnick A,Levine R,Leslie C,Lengner CJ,Kharas MG

Mon Mar 02 00:00:00 EST 2015

Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.

The Journal of clinical investigation

Park SM,Gönen M,Vu L,Minuesa G,Tivnan P,Barlowe TS,Taggart J,Lu Y,Deering RP,Hacohen N,Figueroa ME,Paietta E,Fernandez HF,Tallman MS,Melnick A,Levine R,Leslie C,Lengner CJ,Kharas MG

Mon Mar 02 00:00:00 EST 2015

Coordinate expression of heme and globin is essential for effective erythropoiesis.

The Journal of clinical investigation

Doty RT,Phelps SR,Shadle C,Sanchez-Bonilla M,Keel SB,Abkowitz JL

Tue Dec 01 00:00:00 EST 2015

Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.

The Journal of clinical investigation

Hadland BK,Varnum-Finney B,Poulos MG,Moon RT,Butler JM,Rafii S,Bernstein ID

Fri May 01 00:00:00 EDT 2015

Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.

The Journal of clinical investigation

Duque-Afonso J,Feng J,Scherer F,Lin CH,Wong SH,Wang Z,Iwasaki M,Cleary ML

Tue Sep 01 00:00:00 EDT 2015

A single glycan on IgE is indispensable for initiation of anaphylaxis.

The Journal of experimental medicine

Shade KT,Platzer B,Washburn N,Mani V,Bartsch YC,Conroy M,Pagan JD,Bosques C,Mempel TR,Fiebiger E,Anthony RM

Mon Apr 06 00:00:00 EDT 2015

Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors.

The Journal of experimental medicine

Ungerbäck J,Åhsberg J,Strid T,Somasundaram R,Sigvardsson M

Mon Jun 29 00:00:00 EDT 2015

Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.

The Journal of experimental medicine

Diaz MF,Li N,Lee HJ,Adamo L,Evans SM,Willey HE,Arora N,Torisawa YS,Vickers DA,Morris SA,Naveiras O,Murthy SK,Ingber DE,Daley GQ,García-Cardeña G,Wenzel PL

Mon May 04 00:00:00 EDT 2015

Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.

The Journal of experimental medicine

Xia P,Wang S,Du Y,Huang G,Satoh T,Akira S,Fan Z

Mon Dec 14 00:00:00 EST 2015

The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.

The Journal of experimental medicine

Yu Y,Wang C,Clare S,Wang J,Lee SC,Brandt C,Burke S,Lu L,He D,Jenkins NA,Copeland NG,Dougan G,Liu P

Mon Jun 01 00:00:00 EDT 2015

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.

The Journal of experimental medicine

Mullenders J,Aranda-Orgilles B,Lhoumaud P,Keller M,Pae J,Wang K,Kayembe C,Rocha PP,Raviram R,Gong Y,Premsrirut PK,Tsirigos A,Bonneau R,Skok JA,Cimmino L,Hoehn D,Aifantis I

Mon Oct 19 00:00:00 EDT 2015

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.

The Journal of experimental medicine

Mullenders J,Aranda-Orgilles B,Lhoumaud P,Keller M,Pae J,Wang K,Kayembe C,Rocha PP,Raviram R,Gong Y,Premsrirut PK,Tsirigos A,Bonneau R,Skok JA,Cimmino L,Hoehn D,Aifantis I

Mon Oct 19 00:00:00 EDT 2015

DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3.

The Journal of experimental medicine

Thompson BJ,Bhansali R,Diebold L,Cook DE,Stolzenburg L,Casagrande AS,Besson T,Leblond B,Désiré L,Malinge S,Crispino JD

Mon Jun 01 00:00:00 EDT 2015

Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells.

Proceedings of the National Academy of Sciences of the United States of America

Smith DJ,Liu S,Ji S,Li B,McLaughlin J,Cheng D,Witte ON,Yang L

Tue Feb 03 00:00:00 EST 2015

Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Godec J,Cowley GS,Barnitz RA,Alkan O,Root DE,Sharpe AH,Haining WN

Tue Jan 13 00:00:00 EST 2015

Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.

British journal of haematology

Sjögren SE,Siva K,Soneji S,George AJ,Winkler M,Jaako P,Wlodarski M,Karlsson S,Hannan RD,Flygare J

Sun Nov 01 00:00:00 EDT 2015

MN1-Fli1 oncofusion transforms murine hematopoietic progenitor cells into acute megakaryoblastic leukemia cells.

Oncogenesis

Wenge DV,Felipe-Fumero E,Angenendt L,Schliemann C,Schmidt E,Schmidt LH,Thiede C,Ehninger G,Berdel WE,Arteaga MF,Mikesch JH

Mon Dec 21 00:00:00 EST 2015

Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.

Stem cells (Dayton, Ohio)

Zeng Y,Broxmeyer HE,Staser K,Chitteti BR,Park SJ,Hahn S,Cooper S,Sun Z,Jiang L,Yang X,Yuan J,Kosoff R,Sandusky G,Srour EF,Chernoff J,Clapp DW

Fri May 01 00:00:00 EDT 2015

Bmi1 promotes erythroid development through regulating ribosome biogenesis.

Stem cells (Dayton, Ohio)

Gao R,Chen S,Kobayashi M,Yu H,Zhang Y,Wan Y,Young SK,Soltis A,Yu M,Vemula S,Fraenkel E,Cantor A,Antipin Y,Xu Y,Yoder MC,Wek RC,Ellis SR,Kapur R,Zhu X,Liu Y

Sun Mar 01 00:00:00 EST 2015

Bmi1 promotes erythroid development through regulating ribosome biogenesis.

Stem cells (Dayton, Ohio)

Gao R,Chen S,Kobayashi M,Yu H,Zhang Y,Wan Y,Young SK,Soltis A,Yu M,Vemula S,Fraenkel E,Cantor A,Antipin Y,Xu Y,Yoder MC,Wek RC,Ellis SR,Kapur R,Zhu X,Liu Y

Sun Mar 01 00:00:00 EST 2015

The orphan nuclear receptor NR4A1 specifies a distinct subpopulation of quiescent myeloid-biased long-term HSCs.

Stem cells (Dayton, Ohio)

Land RH,Rayne AK,Vanderbeck AN,Barlowe TS,Manjunath S,Gross M,Eiger S,Klein PS,Cunningham NR,Huang J,Emerson SG,Punt JA

Thu Jan 01 00:00:00 EST 2015

Contrasting roles for C/EBPα and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects.

Stem cells (Dayton, Ohio)

Fleenor CJ,Rozhok AI,Zaberezhnyy V,Mathew D,Kim J,Tan AC,Bernstein ID,DeGregori J

Wed Apr 01 00:00:00 EDT 2015

Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.

Journal of immunology (Baltimore, Md. : 1950)

Krishnamoorthy V,Carr T,de Pooter RF,Emanuelle AO,Gounari F,Kee BL

Wed Apr 01 00:00:00 EDT 2015

Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation.

Journal of immunology (Baltimore, Md. : 1950)

Xiao Y,Qiao G,Tang J,Tang R,Guo H,Warwar S,Langdon WY,Tao L,Zhang J

Sun Nov 01 00:00:00 EDT 2015

Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency.

Journal of immunology (Baltimore, Md. : 1950)

Boland BS,Widjaja CE,Banno A,Zhang B,Kim SH,Stoven S,Peterson MR,Jones MC,Su HI,Crowe SE,Bui JD,Ho SB,Okugawa Y,Goel A,Marietta EV,Khosroheidari M,Jepsen K,Aramburu J,López-Rodríguez C,Sandborn WJ,Murray JA,Harismendy O,Chang JT

Sun Mar 15 00:00:00 EDT 2015

The T Cell Repertoire-Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens.

Journal of immunology (Baltimore, Md. : 1950)

Viret C,Mahiddine K,Baker RL,Haskins K,Guerder S

Tue Sep 01 00:00:00 EDT 2015

Heme exporter FLVCR is required for T cell development and peripheral survival.

Journal of immunology (Baltimore, Md. : 1950)

Philip M,Funkhouser SA,Chiu EY,Phelps SR,Delrow JJ,Cox J,Fink PJ,Abkowitz JL

Sun Feb 15 00:00:00 EST 2015

Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis.

Journal of immunology (Baltimore, Md. : 1950)

Ottina E,Lyberg K,Sochalska M,Villunger A,Nilsson GP

Sun Feb 01 00:00:00 EST 2015

Microtubule nucleation in mouse bone marrow-derived mast cells is regulated by the concerted action of GIT1/βPIX proteins and calcium.

Journal of immunology (Baltimore, Md. : 1950)

Sulimenko V,Hájková Z,Černohorská M,Sulimenko T,Sládková V,Dráberová L,Vinopal S,Dráberová E,Dráber P

Fri May 01 00:00:00 EDT 2015

Identification of a New Exo-Endocytic Mechanism Triggered by Corticotropin-Releasing Hormone in Mast Cells.

Journal of immunology (Baltimore, Md. : 1950)

Balseiro-Gomez S,Flores JA,Acosta J,Ramirez-Ponce MP,Ales E

Tue Sep 01 00:00:00 EDT 2015

Eosinophils Contribute to Early Clearance of Pneumocystis murina Infection.

Journal of immunology (Baltimore, Md. : 1950)

Eddens T,Elsegeiny W,Nelson MP,Horne W,Campfield BT,Steele C,Kolls JK

Wed Jul 01 00:00:00 EDT 2015

IFN-γ regulates CD8+ memory T cell differentiation and survival in response to weak, but not strong, TCR signals.

Journal of immunology (Baltimore, Md. : 1950)

Stoycheva D,Deiser K,Stärck L,Nishanth G,Schlüter D,Uckert W,Schüler T

Thu Jan 15 00:00:00 EST 2015

Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy.

Molecular therapy. Methods & clinical development

Ungari S,Montepeloso A,Morena F,Cocchiarella F,Recchia A,Martino S,Gentner B,Naldini L,Biffi A

Wed Oct 28 00:00:00 EDT 2015

Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy.

Molecular therapy. Methods & clinical development

Wielgosz MM,Kim YS,Carney GG,Zhan J,Reddivari M,Coop T,Heath RJ,Brown SA,Nienhuis AW

250-03 was used in In vitro experiments to show that the producer cell line and the specific monoclonal antibody will facilitate the development of a clinical protocol for gene transfer into WAS protein deficient stem cells.

Mon Jun 08 00:00:00 EDT 2015

CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis.

Nature communications

Murayama MA,Kakuta S,Inoue A,Umeda N,Yonezawa T,Maruhashi T,Tateishi K,Ishigame H,Yabe R,Ikeda S,Seno A,Chi HH,Hashiguchi Y,Kurata R,Tada T,Kubo S,Sato N,Liu Y,Hattori M,Saijo S,Matsushita M,Fujita T,Sumida T,Iwakura Y

Fri Sep 25 00:00:00 EDT 2015

Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.

Nature communications

Buchner M,Park E,Geng H,Klemm L,Flach J,Passegué E,Schjerven H,Melnick A,Paietta E,Kopanja D,Raychaudhuri P,Müschen M

Tue Mar 10 00:00:00 EDT 2015

In Vitro Derivation of Melanocytes from Embryonic Neural Crest Stem Cells.

Methods in molecular biology (Clifton, N.J.)

Shakhova O,Sommer L

250-03 was used in Cell Culture to investigate the differentiation of multipotent embryonic neural crest stem cells into differentiated pigmented melanocytes.

Sun Dec 13 00:00:00 EST 2015

Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex.

Nature communications

Balasubramani A,Larjo A,Bassein JA,Chang X,Hastie RB,Togher SM,Lähdesmäki H,Rao A

Mon Jun 22 00:00:00 EDT 2015

Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.

Stem cell reports

Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F

Tue Oct 13 00:00:00 EDT 2015

Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.

Scientific reports

Xie XQ,Yang P,Zhang Y,Zhang P,Wang L,Ding Y,Yang M,Tong Q,Cheng H,Ji Q,McGuire T,Yuan W,Cheng T,Gao Y

Fri Dec 18 00:00:00 EST 2015

Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.

Scientific reports

Xie XQ,Yang P,Zhang Y,Zhang P,Wang L,Ding Y,Yang M,Tong Q,Cheng H,Ji Q,McGuire T,Yuan W,Cheng T,Gao Y

Fri Dec 18 00:00:00 EST 2015

Fancb deficiency impairs hematopoietic stem cell function.

Scientific reports

Du W,Amarachintha S,Erden O,Wilson A,Meetei AR,Andreassen PR,Namekawa SH,Pang Q

Fri Dec 11 00:00:00 EST 2015

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.

Nature communications

Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J

Mon Oct 12 00:00:00 EDT 2015

Amelioration of murine sickle cell disease by nonablative conditioning and γ-globin gene-corrected bone marrow cells.

Molecular therapy. Methods & clinical development

Pestina TI,Hargrove PW,Zhao H,Mead PE,Smeltzer MP,Weiss MJ,Wilber A,Persons DA

Tue Dec 15 00:00:00 EST 2015

Defective repair of uracil causes telomere defects in mouse hematopoietic cells.

The Journal of biological chemistry

Vallabhaneni H,Zhou F,Maul RW,Sarkar J,Yin J,Lei M,Harrington L,Gearhart PJ,Liu Y

Fri Feb 27 00:00:00 EST 2015

The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.

Stem cell reports

Zhang J,Vakhrusheva O,Bandi SR,Demirel Ö,Kazi JU,Fernandes RG,Jakobi K,Eichler A,Rönnstrand L,Rieger MA,Carpino N,Serve H,Brandts CH

Tue Oct 13 00:00:00 EDT 2015

STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.

Nature communications

Haetscher N,Feuermann Y,Wingert S,Rehage M,Thalheimer FB,Weiser C,Bohnenberger H,Jung K,Schroeder T,Serve H,Oellerich T,Hennighausen L,Rieger MA

Wed Nov 25 00:00:00 EST 2015

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.

Nature

Nakada D,Oguro H,Levi BP,Ryan N,Kitano A,Saitoh Y,Takeichi M,Wendt GR,Morrison SJ

Thu Jan 23 00:00:00 EST 2014

Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.

Cell

Cunningham JT,Moreno MV,Lodi A,Ronen SM,Ruggero D

Thu May 22 00:00:00 EDT 2014

Nonstochastic reprogramming from a privileged somatic cell state.

Cell

Guo S,Zi X,Schulz VP,Cheng J,Zhong M,Koochaki SH,Megyola CM,Pan X,Heydari K,Weissman SM,Gallagher PG,Krause DS,Fan R,Lu J

Thu Feb 13 00:00:00 EST 2014

Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.

Immunity

Nabekura T,Kanaya M,Shibuya A,Fu G,Gascoigne NR,Lanier LL

Thu Feb 20 00:00:00 EST 2014

Blood

Komeno Y,Yan M,Matsuura S,Lam K,Lo MC,Huang YJ,Tenen DG,Downing JR,Zhang DE

Thu Jun 12 00:00:00 EDT 2014

Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia.

Blood

Wang C,Sashida G,Saraya A,Ishiga R,Koide S,Oshima M,Isono K,Koseki H,Iwama A

Thu May 22 00:00:00 EDT 2014

The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells.

Blood

Kobayashi CI,Takubo K,Kobayashi H,Nakamura-Ishizu A,Honda H,Kataoka K,Kumano K,Akiyama H,Sudo T,Kurokawa M,Suda T

Thu Apr 17 00:00:00 EDT 2014

miRNA-130a regulates C/EBP-ε expression during granulopoiesis.

Blood

Larsen MT,Häger M,Glenthøj A,Asmar F,Clemmensen SN,Mora-Jensen H,Borregaard N,Cowland JB

Thu Feb 13 00:00:00 EST 2014

Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.

Blood

Lu EP,McLellan M,Ding L,Fulton R,Mardis ER,Wilson RK,Miller CA,Westervelt P,DiPersio JF,Link DC,Walter MJ,Ley TJ,Graubert TA

Thu Dec 18 00:00:00 EST 2014

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.

Blood

Degryse S,de Bock CE,Cox L,Demeyer S,Gielen O,Mentens N,Jacobs K,Geerdens E,Gianfelici V,Hulselmans G,Fiers M,Aerts S,Meijerink JP,Tousseyn T,Cools J

Thu Nov 13 00:00:00 EST 2014

Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1.

Blood

de Laval B,Pawlikowska P,Barbieri D,Besnard-Guerin C,Cico A,Kumar R,Gaudry M,Baud V,Porteu F

Thu Jan 23 00:00:00 EST 2014

Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation.

Blood

Lan Y,He W,Li Z,Wang Y,Wang J,Gao J,Wang W,Cheng T,Liu B,Yang X

Thu Apr 03 00:00:00 EDT 2014

Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice.

Blood

Pawlikowska P,Fouchet P,Vainchenker W,Rosselli F,Naim V

Thu Dec 04 00:00:00 EST 2014

Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation.

The Journal of clinical investigation

Wegiel B,Larsen R,Gallo D,Chin BY,Harris C,Mannam P,Kaczmarek E,Lee PJ,Zuckerbraun BS,Flavell R,Soares MP,Otterbein LE

Sat Nov 01 00:00:00 EDT 2014

Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

The Journal of clinical investigation

Dahdah A,Gautier G,Attout T,Fiore F,Lebourdais E,Msallam R,Daëron M,Monteiro RC,Benhamou M,Charles N,Davoust J,Blank U,Malissen B,Launay P

Wed Oct 01 00:00:00 EDT 2014

Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation.

The Journal of clinical investigation

Jones M,Osawa G,Regal JA,Weinberg DN,Taggart J,Kocak H,Friedman A,Ferguson DO,Keegan CE,Maillard I

Wed Jan 01 00:00:00 EST 2014

iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.

The Journal of clinical investigation

Wu J,Yang J,Yang K,Wang H,Gorentla B,Shin J,Qiu Y,Que LG,Foster WM,Xia Z,Chi H,Zhong XP

250-03 was used in Cell Culture to study how invariant NKT (iNKT) terminal maturation is regulated and what factors mediate the predominance of iNKT-1 compared with iNKT-17 to indicate that tumor suppressor tuberous sclerosis 1 (TSC1)-dependent control of mTORC1 is crucial for terminal iNKT maturation and effector lineage decisions.

Tue Apr 01 00:00:00 EDT 2014

iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.

The Journal of clinical investigation

Wu J,Yang J,Yang K,Wang H,Gorentla B,Shin J,Qiu Y,Que LG,Foster WM,Xia Z,Chi H,Zhong XP

Tue Apr 01 00:00:00 EDT 2014

Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression.

The Journal of clinical investigation

Sungalee S,Mamessier E,Morgado E,Grégoire E,Brohawn PZ,Morehouse CA,Jouve N,Monvoisin C,Menard C,Debroas G,Faroudi M,Mechin V,Navarro JM,Drevet C,Eberle FC,Chasson L,Baudimont F,Mancini SJ,Tellier J,Picquenot JM,Kelly R,Vineis P,Ruminy P,Chetaille B,Jaffe ES,Schiff C,Hardwigsen J,Tice DA,Higgs BW,Tarte K,Nadel B,Roulland S

Mon Dec 01 00:00:00 EST 2014

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.

The Journal of clinical investigation

Bestas B,Moreno PM,Blomberg KE,Mohammad DK,Saleh AF,Sutlu T,Nordin JZ,Guterstam P,Gustafsson MO,Kharazi S,Piątosa B,Roberts TC,Behlke MA,Wood MJ,Gait MJ,Lundin KE,El Andaloussi S,Månsson R,Berglöf A,Wengel J,Smith CI

Mon Sep 01 00:00:00 EDT 2014

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.

The Journal of clinical investigation

Smeets MF,DeLuca E,Wall M,Quach JM,Chalk AM,Deans AJ,Heierhorst J,Purton LE,Izon DJ,Walkley CR

Fri Aug 01 00:00:00 EDT 2014

The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.

The Journal of experimental medicine

Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ

Mon Apr 07 00:00:00 EDT 2014

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.

The Journal of experimental medicine

Lancini C,van den Berk PC,Vissers JH,Gargiulo G,Song JY,Hulsman D,Serresi M,Tanger E,Blom M,Vens C,van Lohuizen M,Jacobs H,Citterio E

Mon Aug 25 00:00:00 EDT 2014

CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.

The Journal of experimental medicine

Beck TC,Gomes AC,Cyster JG,Pereira JP

Mon Dec 15 00:00:00 EST 2014

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.

The Journal of experimental medicine

Pietras EM,Lakshminarasimhan R,Techner JM,Fong S,Flach J,Binnewies M,Passegué E

Mon Feb 10 00:00:00 EST 2014

Initiation of MLL-rearranged AML is dependent on C/EBPα.

The Journal of experimental medicine

Ohlsson E,Hasemann MS,Willer A,Lauridsen FK,Rapin N,Jendholm J,Porse BT

Mon Jan 13 00:00:00 EST 2014

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

The Journal of experimental medicine

Järås M,Miller PG,Chu LP,Puram RV,Fink EC,Schneider RK,Al-Shahrour F,Peña P,Breyfogle LJ,Hartwell KA,McConkey ME,Cowley GS,Root DE,Kharas MG,Mullally A,Ebert BL

Mon Apr 07 00:00:00 EDT 2014

WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.

The Journal of experimental medicine

Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z

Mon Sep 22 00:00:00 EDT 2014

Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.

The Journal of experimental medicine

Wang D,Zheng M,Qiu Y,Guo C,Ji J,Lei L,Zhang X,Liang J,Lou J,Huang W,Dong B,Wu S,Wang J,Ke Y,Cao X,Zhou YT,Lu L

Mon Dec 15 00:00:00 EST 2014

Fgd5 identifies hematopoietic stem cells in the murine bone marrow.

The Journal of experimental medicine

Gazit R,Mandal PK,Ebina W,Ben-Zvi A,Nombela-Arrieta C,Silberstein LE,Rossi DJ

Mon Jun 30 00:00:00 EDT 2014

High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias.

The Journal of experimental medicine

Shin JY,Hu W,Naramura M,Park CY

Mon Feb 10 00:00:00 EST 2014

IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms.

EMBO molecular medicine

Wang J,Lindholt JS,Sukhova GK,Shi MA,Xia M,Chen H,Xiang M,He A,Wang Y,Xiong N,Libby P,Wang JA,Shi GP

Tue Jul 01 00:00:00 EDT 2014

Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes.

Proceedings of the National Academy of Sciences of the United States of America

Shi J,Kundrat L,Pishesha N,Bilate A,Theile C,Maruyama T,Dougan SK,Ploegh HL,Lodish HF

Tue Jul 15 00:00:00 EDT 2014

IL-33/ST2 axis promotes mast cell survival via BCLXL.

Proceedings of the National Academy of Sciences of the United States of America

Wang JX,Kaieda S,Ameri S,Fishgal N,Dwyer D,Dellinger A,Kepley CL,Gurish MF,Nigrovic PA

Tue Jul 15 00:00:00 EDT 2014

PDK1 regulates B cell differentiation and homeostasis.

Proceedings of the National Academy of Sciences of the United States of America

Baracho GV,Cato MH,Zhu Z,Jaren OR,Hobeika E,Reth M,Rickert RC

Tue Jul 01 00:00:00 EDT 2014

Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.

Blood cancer journal

Sprissler C,Belenki D,Maurer H,Aumann K,Pfeifer D,Klein C,Müller TA,Kissel S,Hülsdünker J,Alexandrovski J,Brummer T,Jumaa H,Duyster J,Dierks C

Fri Aug 22 00:00:00 EDT 2014

Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis.

Blood cancer journal

Nakaya Y,Shide K,Naito H,Niwa T,Horio T,Miyake J,Shimoda K

Fri Jan 10 00:00:00 EST 2014

Identification of multipotent progenitors that emerge prior to hematopoietic stem cells in embryonic development.

Stem cell reports

Inlay MA,Serwold T,Mosley A,Fathman JW,Dimov IK,Seita J,Weissman IL

250-03 was used in Sample Preparation (FC/FACS) to develop a single-cell multipotency assay which can be used to identify when and where clonal multilineage potential arises during embryogenesis.

Tue Apr 08 00:00:00 EDT 2014

Dendritic cell development requires histone deacetylase activity.

European journal of immunology

Chauvistré H,Küstermann C,Rehage N,Klisch T,Mitzka S,Felker P,Rose-John S,Zenke M,Seré KM

Fri Aug 01 00:00:00 EDT 2014

Twist-1, a novel regulator of hematopoietic stem cell self-renewal and myeloid lineage development.

Stem cells (Dayton, Ohio)

Dong CY,Liu XY,Wang N,Wang LN,Yang BX,Ren Q,Liang HY,Ma XT

Mon Dec 01 00:00:00 EST 2014

Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.

Stem cells (Dayton, Ohio)

Povinelli BJ,Nemeth MJ

Wed Jan 01 00:00:00 EST 2014

Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming.

Stem cells (Dayton, Ohio)

Zdzieblo D,Li X,Lin Q,Zenke M,Illich DJ,Becker M,Müller AM

Mon Dec 01 00:00:00 EST 2014

Carbonic anhydrase IV is expressed on IL-5-activated murine eosinophils.

Journal of immunology (Baltimore, Md. : 1950)

Wen T,Mingler MK,Wahl B,Khorki ME,Pabst O,Zimmermann N,Rothenberg ME

Sun Jun 15 00:00:00 EDT 2014

Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis.

Journal of immunology (Baltimore, Md. : 1950)

Azouz NP,Zur N,Efergan A,Ohbayashi N,Fukuda M,Amihai D,Hammel I,Rothenberg ME,Sagi-Eisenberg R

Thu May 01 00:00:00 EDT 2014

Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors.

Journal of immunology (Baltimore, Md. : 1950)

Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y

Sun Jun 15 00:00:00 EDT 2014

Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling.

Journal of immunology (Baltimore, Md. : 1950)

Balmer ML,Schürch CM,Saito Y,Geuking MB,Li H,Cuenca M,Kovtonyuk LV,McCoy KD,Hapfelmeier S,Ochsenbein AF,Manz MG,Slack E,Macpherson AJ

Sat Nov 15 00:00:00 EST 2014

SAP-regulated T Cell-APC adhesion and ligation-dependent and -independent Ly108-CD3ζ interactions.

Journal of immunology (Baltimore, Md. : 1950)

Chu C,Wang Y,Zhang X,Ni X,Cao J,Xu W,Dong Z,Yuan P,Wei W,Ma Y,Zhang L,Wu L,Qi H

Wed Oct 15 00:00:00 EDT 2014

Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation.

Journal of immunology (Baltimore, Md. : 1950)

Brochetta C,Suzuki R,Vita F,Soranzo MR,Claver J,Madjene LC,Attout T,Vitte J,Varin-Blank N,Zabucchi G,Rivera J,Blank U

Wed Jan 01 00:00:00 EST 2014

SHP2 phosphatase promotes mast cell chemotaxis toward stem cell factor via enhancing activation of the Lyn/Vav/Rac signaling axis.

Journal of immunology (Baltimore, Md. : 1950)

Sharma N,Everingham S,Ramdas B,Kapur R,Craig AW

Thu May 15 00:00:00 EDT 2014

Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell-derived T cells.

Journal of immunology (Baltimore, Md. : 1950)

Stärck L,Popp K,Pircher H,Uckert W

Wed Jan 01 00:00:00 EST 2014

Maintenance and neuronal differentiation of chicken induced pluripotent stem-like cells.

Stem cells international

Dai R,Rossello R,Chen CC,Kessler J,Davison I,Hochgeschwender U,Jarvis ED

250-03 was used in Cell Culture to demonstrate an efficient method of maintaining chicken induced pluripotent stem (iPSC)-like cells and for differentiating them into action potential generating neurons.

Thu Jan 22 00:00:00 EST 2015

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.

Nature communications

Piunti A,Rossi A,Cerutti A,Albert M,Jammula S,Scelfo A,Cedrone L,Fragola G,Olsson L,Koseki H,Testa G,Casola S,Helin K,d'Adda di Fagagna F,Pasini D

Mon Apr 14 00:00:00 EDT 2014

Bone Marrow Derived Eosinophil Cultures.

Bio-protocol

Lu TX,Rothenberg ME

250-03 was used in Cell Culture to describe how bone marrow derived eosinophils are fully differentiated at the end of a 14 day culture based on morphology and expression of molecular markers.

Fri Jun 20 00:00:00 EDT 2014

The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression.

Cell death & disease

Becker MS,Schmezer P,Breuer R,Haas SF,Essers MA,Krammer PH,Li-Weber M

Thu Jan 16 00:00:00 EST 2014

Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation.

Nature communications

Obata Y,Toyoshima S,Wakamatsu E,Suzuki S,Ogawa S,Esumi H,Abe R

Wed Dec 10 00:00:00 EST 2014

Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.

Cell death & disease

Lu H,Fang EF,Sykora P,Kulikowicz T,Zhang Y,Becker KG,Croteau DL,Bohr VA

Thu May 15 00:00:00 EDT 2014

Regulation of Fc∈RI signaling in mast cells by G protein-coupled receptor kinase 2 and its RH domain.

The Journal of biological chemistry

Subramanian H,Gupta K,Parameswaran N,Ali H

Fri Jul 25 00:00:00 EDT 2014

FOXO3A directs a protective autophagy program in haematopoietic stem cells.

Nature

Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E

Thu Feb 21 00:00:00 EST 2013

The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.

Cancer cell

Arteaga MF,Mikesch JH,Qiu J,Christensen J,Helin K,Kogan SC,Dong S,So CW

Mon Mar 18 00:00:00 EDT 2013

A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.

Blood

Conway AE,Scotland PB,Lavau CP,Wechsler DS

Thu Jun 06 00:00:00 EDT 2013

Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling.

Blood

Malinge S,Thiollier C,Chlon TM,Doré LC,Diebold L,Bluteau O,Mabialah V,Vainchenker W,Dessen P,Winandy S,Mercher T,Crispino JD

Thu Mar 28 00:00:00 EDT 2013

Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival.

Blood

Holmfeldt P,Pardieck J,Saulsberry AC,Nandakumar SK,Finkelstein D,Gray JT,Persons DA,McKinney-Freeman S

Thu Oct 24 00:00:00 EDT 2013

Interferon-γ impairs proliferation of hematopoietic stem cells in mice.

Blood

de Bruin AM,Demirel Ö,Hooibrink B,Brandts CH,Nolte MA

Thu May 02 00:00:00 EDT 2013

Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.

Blood

May RM,Okumura M,Hsu CJ,Bassiri H,Yang E,Rak G,Mace EM,Philip NH,Zhang W,Baumgart T,Orange JS,Nichols KE,Kambayashi T

Thu Apr 18 00:00:00 EDT 2013

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

Blood

Santoro F,Botrugno OA,Dal Zuffo R,Pallavicini I,Matthews GM,Cluse L,Barozzi I,Senese S,Fornasari L,Moretti S,Altucci L,Pelicci PG,Chiocca S,Johnstone RW,Minucci S

Thu Apr 25 00:00:00 EDT 2013

Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.

Blood

Shieh A,Ward AF,Donlan KL,Harding-Theobald ER,Xu J,Mullighan CG,Zhang C,Chen SC,Su X,Downing JR,Bollag GE,Shannon KM

Thu Jun 13 00:00:00 EDT 2013

Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs.

Blood

Gordon-Keylock S,Sobiesiak M,Rybtsov S,Moore K,Medvinsky A

Thu Oct 03 00:00:00 EDT 2013

Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression.

Blood

Laperrousaz B,Jeanpierre S,Sagorny K,Voeltzel T,Ramas S,Kaniewski B,Ffrench M,Salesse S,Nicolini FE,Maguer-Satta V

Thu Nov 28 00:00:00 EST 2013

An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.

Blood

Wahlestedt M,Norddahl GL,Sten G,Ugale A,Frisk MA,Mattsson R,Deierborg T,Sigvardsson M,Bryder D

Thu May 23 00:00:00 EDT 2013

Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk.

The Journal of clinical investigation

Staser K,Park SJ,Rhodes SD,Zeng Y,He YZ,Shew MA,Gehlhausen JR,Cerabona D,Menon K,Chen S,Sun Z,Yuan J,Ingram DA,Nalepa G,Yang FC,Clapp DW

Tue Jan 01 00:00:00 EST 2013

Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica.

The Journal of clinical investigation

Zhang H,Verkman AS

Wed May 01 00:00:00 EDT 2013

GSK3β regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement.

The Journal of clinical investigation

Lapid K,Itkin T,D'Uva G,Ovadya Y,Ludin A,Caglio G,Kalinkovich A,Golan K,Porat Z,Zollo M,Lapidot T

Mon Apr 01 00:00:00 EDT 2013

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.

The Journal of clinical investigation

Martin H,Mali RS,Ma P,Chatterjee A,Ramdas B,Sims E,Munugalavadla V,Ghosh J,Mattingly RR,Visconte V,Tiu RV,Vlaar CP,Dharmawardhane S,Kapur R

Tue Oct 01 00:00:00 EDT 2013

TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells.

The Journal of experimental medicine

Yi Z,Stunz LL,Bishop GA

Mon Jun 03 00:00:00 EDT 2013

Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance.

The Journal of experimental medicine

Singh SK,Williams CA,Klarmann K,Burkett SS,Keller JR,Oberdoerffer P

Mon May 06 00:00:00 EDT 2013

Notch pathway activation targets AML-initiating cell homeostasis and differentiation.

The Journal of experimental medicine

Lobry C,Ntziachristos P,Ndiaye-Lobry D,Oh P,Cimmino L,Zhu N,Araldi E,Hu W,Freund J,Abdel-Wahab O,Ibrahim S,Skokos D,Armstrong SA,Levine RL,Park CY,Aifantis I

Mon Feb 11 00:00:00 EST 2013

SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.

Leukemia

Hansen N,Ågerstam H,Wahlestedt M,Landberg N,Askmyr M,Ehinger M,Rissler M,Lilljebjörn H,Johnels P,Ishiko J,Melo JV,Alexander WS,Bryder D,Järås M,Fioretos T

Tue Jan 01 00:00:00 EST 2013

Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling.

Proceedings of the National Academy of Sciences of the United States of America

Jin HS,Liao L,Park Y,Liu YC

Tue Jan 08 00:00:00 EST 2013

CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Arndt K,Grinenko T,Mende N,Reichert D,Portz M,Ripich T,Carmeliet P,Corbeil D,Waskow C

Tue Apr 02 00:00:00 EDT 2013

Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Wen T,Besse JA,Mingler MK,Fulkerson PC,Rothenberg ME

Tue Apr 09 00:00:00 EDT 2013

Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells.

Proceedings of the National Academy of Sciences of the United States of America

Chan CK,Lindau P,Jiang W,Chen JY,Zhang LF,Chen CC,Seita J,Sahoo D,Kim JB,Lee A,Park S,Nag D,Gong Y,Kulkarni S,Luppen CA,Theologis AA,Wan DC,DeBoer A,Seo EY,Vincent-Tompkins JD,Loh K,Walmsley GG,Kraft DL,Wu JC,Longaker MT,Weissman IL

Tue Jul 30 00:00:00 EDT 2013

Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity.

Blood cancer journal

Pannucci NL,Li D,Sahay S,Thomas EK,Chen R,Tala I,Hu T,Ciccarelli BT,Megjugorac NJ,Adams Iii HC,Rodriguez PL,Fitzpatrick ER,Lagunoff D,Williams DA,Whitehead IP

Fri Aug 16 00:00:00 EDT 2013

Runx1 deficiency permits granulocyte lineage commitment but impairs subsequent maturation.

Oncogenesis

Ng KP,Hu Z,Ebrahem Q,Negrotto S,Lausen J,Saunthararajah Y

Mon Nov 04 00:00:00 EST 2013

Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury.

Stem cells (Dayton, Ohio)

Porter RL,Georger MA,Bromberg O,McGrath KE,Frisch BJ,Becker MW,Calvi LM

Fri Feb 01 00:00:00 EST 2013

p130Cas alters the differentiation potential of mammary luminal progenitors by deregulating c-Kit activity.

Stem cells (Dayton, Ohio)

Tornillo G,Elia AR,Castellano I,Spadaro M,Bernabei P,Bisaro B,Camacho-Leal Mdel P,Pincini A,Provero P,Sapino A,Turco E,Defilippi P,Cabodi S

Mon Jul 01 00:00:00 EDT 2013

The IL-33/ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis.

Journal of immunology (Baltimore, Md. : 1950)

Sesti-Costa R,Silva GK,Proença-Módena JL,Carlos D,Silva ML,Alves-Filho JC,Arruda E,Liew FY,Silva JS

Mon Jul 01 00:00:00 EDT 2013

Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.

Journal of immunology (Baltimore, Md. : 1950)

Fernando J,Faber TW,Pullen NA,Falanga YT,Kolawole EM,Oskeritzian CA,Barnstein BO,Bandara G,Li G,Schwartz LB,Spiegel S,Straus DB,Conrad DH,Bunting KD,Ryan JJ

Fri Nov 01 00:00:00 EDT 2013

Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.

Journal of immunology (Baltimore, Md. : 1950)

Fernando J,Faber TW,Pullen NA,Falanga YT,Kolawole EM,Oskeritzian CA,Barnstein BO,Bandara G,Li G,Schwartz LB,Spiegel S,Straus DB,Conrad DH,Bunting KD,Ryan JJ

Fri Nov 01 00:00:00 EDT 2013

Mast cell FcεRI-induced early growth response 2 regulates CC chemokine ligand 1-dependent CD4+ T cell migration.

Journal of immunology (Baltimore, Md. : 1950)

Wu Z,Macneil AJ,Junkins R,Li B,Berman JN,Lin TJ

Wed May 01 00:00:00 EDT 2013

MiR-223 deficiency increases eosinophil progenitor proliferation.

Journal of immunology (Baltimore, Md. : 1950)

Lu TX,Lim EJ,Besse JA,Itskovich S,Plassard AJ,Fulkerson PC,Aronow BJ,Rothenberg ME

Fri Feb 15 00:00:00 EST 2013

Calcineurin-Rcan1 interaction contributes to stem cell factor-mediated mast cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Wu Z,Li Y,MacNeil AJ,Junkins RD,Berman JN,Lin TJ

Sun Dec 15 00:00:00 EST 2013

IL-33 markedly activates murine eosinophils by an NF-κB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop.

Journal of immunology (Baltimore, Md. : 1950)

Bouffi C,Rochman M,Zust CB,Stucke EM,Kartashov A,Fulkerson PC,Barski A,Rothenberg ME

Tue Oct 15 00:00:00 EDT 2013

Inflammatory response of mast cells during influenza A virus infection is mediated by active infection and RIG-I signaling.

Journal of immunology (Baltimore, Md. : 1950)

Graham AC,Hilmer KM,Zickovich JM,Obar JJ

Wed May 01 00:00:00 EDT 2013

GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.

Journal of immunology (Baltimore, Md. : 1950)

Paster W,Brockmeyer C,Fu G,Simister PC,de Wet B,Martinez-Riaño A,Hoerter JA,Feller SM,Wülfing C,Gascoigne NR,Acuto O

Mon Apr 01 00:00:00 EDT 2013

Morphine prevents lipopolysaccharide-induced TNF secretion in mast cells blocking IκB kinase activation and SNAP-23 phosphorylation: correlation with the formation of a β-arrestin/TRAF6 complex.

Journal of immunology (Baltimore, Md. : 1950)

Madera-Salcedo IK,Cruz SL,Gonzalez-Espinosa C

Sun Sep 15 00:00:00 EDT 2013

Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined.

Journal of immunology (Baltimore, Md. : 1950)

Dillahunt SE,Sargent JL,Suzuki R,Proia RL,Gilfillan A,Rivera J,Olivera A

Fri Mar 01 00:00:00 EST 2013

The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics.

The Journal of biological chemistry

Chacón-Martínez CA,Kiessling N,Winterhoff M,Faix J,Müller-Reichert T,Jessberger R

Fri Oct 04 00:00:00 EDT 2013

Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity.

The Journal of biological chemistry

Kosoff R,Chow HY,Radu M,Chernoff J

Fri Jan 11 00:00:00 EST 2013

Heparan sulfate 6-O-sulfotransferase isoform-dependent regulatory effects of heparin on the activities of various proteases in mast cells and the biosynthesis of 6-O-sulfated heparin.

The Journal of biological chemistry

Anower-E-Khuda MF,Habuchi H,Nagai N,Habuchi O,Yokochi T,Kimata K

Fri Feb 08 00:00:00 EST 2013

Mast cells express 11β-hydroxysteroid dehydrogenase type 1: a role in restraining mast cell degranulation.

PloS one

Coutinho AE,Brown JK,Yang F,Brownstein DG,Gray M,Seckl JR,Savill JS,Chapman KE

Fri Jul 19 00:00:00 EDT 2013

Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.

PloS one

Fossati-Jimack L,Ling GS,Cortini A,Szajna M,Malik TH,McDonald JU,Pickering MC,Cook HT,Taylor PR,Botto M

Fri Sep 27 00:00:00 EDT 2013

Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.

The Journal of biological chemistry

Åhsberg J,Ungerbäck J,Strid T,Welinder E,Stjernberg J,Larsson M,Qian H,Sigvardsson M

Fri Nov 15 00:00:00 EST 2013

Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.

Cell

Deng W,Lee J,Wang H,Miller J,Reik A,Gregory PD,Dean A,Blobel GA

Fri Jun 08 00:00:00 EDT 2012

An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.

Cancer cell

Gruber TA,Larson Gedman A,Zhang J,Koss CS,Marada S,Ta HQ,Chen SC,Su X,Ogden SK,Dang J,Wu G,Gupta V,Andersson AK,Pounds S,Shi L,Easton J,Barbato MI,Mulder HL,Manne J,Wang J,Rusch M,Ranade S,Ganti R,Parker M,Ma J,Radtke I,Ding L,Cazzaniga G,Biondi A,Kornblau SM,Ravandi F,Kantarjian H,Nimer SD,Döhner K,Döhner H,Ley TJ,Ballerini P,Shurtleff S,Tomizawa D,Adachi S,Hayashi Y,Tawa A,Shih LY,Liang DC,Rubnitz JE,Pui CH,Mardis ER,Wilson RK,Downing JR

Tue Nov 13 00:00:00 EST 2012

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.

Blood

Tanaka S,Miyagi S,Sashida G,Chiba T,Yuan J,Mochizuki-Kashio M,Suzuki Y,Sugano S,Nakaseko C,Yokote K,Koseki H,Iwama A

Thu Aug 02 00:00:00 EDT 2012

Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.

Blood

Lin DC,Yin T,Koren-Michowitz M,Ding LW,Gueller S,Gery S,Tabayashi T,Bergholz U,Kazi JU,Rönnstrand L,Stocking C,Koeffler HP

Thu Oct 18 00:00:00 EDT 2012

EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress.

Blood

Peslak SA,Wenger J,Bemis JC,Kingsley PD,Koniski AD,McGrath KE,Palis J

Thu Sep 20 00:00:00 EDT 2012

The tumor suppressor p15Ink4b regulates the differentiation and maturation of conventional dendritic cells.

Blood

Fares J,Koller R,Humeniuk R,Wolff L,Bies J

Thu May 24 00:00:00 EDT 2012

Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo.

Blood

Tang Y,Peitzsch C,Charoudeh HN,Cheng M,Chaves P,Jacobsen SE,Sitnicka E

Thu Jul 05 00:00:00 EDT 2012

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis.

Blood

Yuan H,Wang Z,Li L,Zhang H,Modi H,Horne D,Bhatia R,Chen W

Thu Feb 23 00:00:00 EST 2012

Activated expression of the chemokine Mig after chemotherapy contributes to chemotherapy-induced bone marrow suppression and lethal toxicity.

Blood

Lu H,Zhu S,Qian L,Xiang D,Zhang W,Nie A,Gao J,Wu M,Gao J,Lu B,Yu Y,Han W,Moldenhauer A

Thu May 24 00:00:00 EDT 2012

SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control.

Blood

Reddy PN,Sargin B,Choudhary C,Stein S,Grez M,Müller-Tidow C,Berdel WE,Serve H,Brandts CH

Thu Aug 23 00:00:00 EDT 2012

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.

Blood

Mérino D,Khaw SL,Glaser SP,Anderson DJ,Belmont LD,Wong C,Yue P,Robati M,Phipson B,Fairlie WD,Lee EF,Campbell KJ,Vandenberg CJ,Cory S,Roberts AW,Ludlam MJ,Huang DC,Bouillet P

Thu Jun 14 00:00:00 EDT 2012

Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.

Blood

Ross K,Sedello AK,Todd GP,Paszkowski-Rogacz M,Bird AW,Ding L,Grinenko T,Behrens K,Hubner N,Mann M,Waskow C,Stocking C,Buchholz F

Thu May 03 00:00:00 EDT 2012

IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.

Blood

de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA

Thu Feb 09 00:00:00 EST 2012

Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.

Blood

Zhang Y,Yan X,Sashida G,Zhao X,Rao Y,Goyama S,Whitman SP,Zorko N,Bernot K,Conway RM,Witte D,Wang QF,Tenen DG,Xiao Z,Marcucci G,Mulloy JC,Grimes HL,Caligiuri MA,Huang G

Thu Aug 02 00:00:00 EDT 2012

p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis.

Blood

Krishnan S,Mali RS,Ramdas B,Sims E,Ma P,Ghosh J,Munugalavadla V,Hanneman P,Beane JD,Kapur R

Thu Apr 26 00:00:00 EDT 2012

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.

Blood

Spranger S,Jeremias I,Wilde S,Leisegang M,Stärck L,Mosetter B,Uckert W,Heemskerk MH,Schendel DJ,Frankenberger B

Thu Apr 12 00:00:00 EDT 2012

IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors.

Blood

Becker AM,Michael DG,Satpathy AT,Sciammas R,Singh H,Bhattacharya D

Thu Mar 01 00:00:00 EST 2012

KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.

Blood

Zhao L,Melenhorst JJ,Alemu L,Kirby M,Anderson S,Kench M,Hoogstraten-Miller S,Brinster L,Kamikubo Y,Gilliland DG,Liu PP

Thu Feb 09 00:00:00 EST 2012

Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation.

Blood

Cai M,Langer EM,Gill JG,Satpathy AT,Albring JC,KC W,Murphy TL,Murphy KM

Thu Jul 12 00:00:00 EDT 2012

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.

Blood

Guo H,Ma O,Speck NA,Friedman AD

Thu May 10 00:00:00 EDT 2012

Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice.

Blood

Schepers K,Hsiao EC,Garg T,Scott MJ,Passegué E

Thu Oct 25 00:00:00 EDT 2012

FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation.

Blood

Itkin T,Ludin A,Gradus B,Gur-Cohen S,Kalinkovich A,Schajnovitz A,Ovadya Y,Kollet O,Canaani J,Shezen E,Coffin DJ,Enikolopov GN,Berg T,Piacibello W,Hornstein E,Lapidot T

Thu Aug 30 00:00:00 EDT 2012

FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation.

Blood

Itkin T,Ludin A,Gradus B,Gur-Cohen S,Kalinkovich A,Schajnovitz A,Ovadya Y,Kollet O,Canaani J,Shezen E,Coffin DJ,Enikolopov GN,Berg T,Piacibello W,Hornstein E,Lapidot T

Thu Aug 30 00:00:00 EDT 2012

Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.

Blood

Greenblatt S,Li L,Slape C,Nguyen B,Novak R,Duffield A,Huso D,Desiderio S,Borowitz MJ,Aplan P,Small D

Thu Mar 22 00:00:00 EDT 2012

Critical role of P1-Runx1 in mouse basophil development.

Blood

Mukai K,BenBarak MJ,Tachibana M,Nishida K,Karasuyama H,Taniuchi I,Galli SJ

Thu Jul 05 00:00:00 EDT 2012

Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.

Blood

Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC

Thu Oct 11 00:00:00 EDT 2012

PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.

Blood

van de Laar L,van den Bosch A,Boonstra A,Binda RS,Buitenhuis M,Janssen HL,Coffer PJ,Woltman AM

Thu Dec 13 00:00:00 EST 2012

Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells.

Blood

Asai T,Liu Y,Di Giandomenico S,Bae N,Ndiaye-Lobry D,Deblasio A,Menendez S,Antipin Y,Reva B,Wevrick R,Nimer SD

Thu Aug 23 00:00:00 EDT 2012

Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.

Blood

Sathyanarayana P,Dev A,Pradeep A,Ufkin M,Licht JD,Wojchowski DM

Thu Jun 07 00:00:00 EDT 2012

Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.

Blood

Chang KH,Sanchez-Aguilera A,Shen S,Sengupta A,Madhu MN,Ficker AM,Dunn SK,Kuenzi AM,Arnett JL,Santho RA,Agirre X,Perentesis JP,Deininger MW,Zheng Y,Bustelo XR,Williams DA,Cancelas JA

Thu Jul 26 00:00:00 EDT 2012

Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells.

Blood

Gerrits A,Walasek MA,Olthof S,Weersing E,Ritsema M,Zwart E,van Os R,Bystrykh LV,de Haan G

Thu Jan 12 00:00:00 EST 2012

14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells.

The Journal of clinical investigation

Jiang J,Balcerek J,Rozenova K,Cheng Y,Bersenev A,Wu C,Song Y,Tong W

Fri Jun 01 00:00:00 EDT 2012

The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

The Journal of clinical investigation

Sugimoto K,Kudo M,Sundaram A,Ren X,Huang K,Bernstein X,Wang Y,Raymond WW,Erle DJ,Abrink M,Caughey GH,Huang X,Sheppard D

Wed Feb 01 00:00:00 EST 2012

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR.

The Journal of clinical investigation

Schoppy DW,Ragland RL,Gilad O,Shastri N,Peters AA,Murga M,Fernandez-Capetillo O,Diehl JA,Brown EJ

Sun Jan 01 00:00:00 EST 2012

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.

The Journal of experimental medicine

Block H,Herter JM,Rossaint J,Stadtmann A,Kliche S,Lowell CA,Zarbock A

Mon Feb 13 00:00:00 EST 2012

Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.

The Journal of experimental medicine

Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM

Mon Jun 04 00:00:00 EDT 2012

Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.

The Journal of experimental medicine

Oguro H,Yuan J,Tanaka S,Miyagi S,Mochizuki-Kashio M,Ichikawa H,Yamazaki S,Koseki H,Nakauchi H,Iwama A

Mon Mar 12 00:00:00 EDT 2012

Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.

The Journal of experimental medicine

Cherrier M,Sawa S,Eberl G

Mon Apr 09 00:00:00 EDT 2012

Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.

The Journal of experimental medicine

Nowak EC,de Vries VC,Wasiuk A,Ahonen C,Bennett KA,Le Mercier I,Ha DG,Noelle RJ

Mon Oct 22 00:00:00 EDT 2012

ZBTB1 is a determinant of lymphoid development.

The Journal of experimental medicine

Siggs OM,Li X,Xia Y,Beutler B

Mon Jan 16 00:00:00 EST 2012

Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells.

Proceedings of the National Academy of Sciences of the United States of America

Taniguchi Ishikawa E,Gonzalez-Nieto D,Ghiaur G,Dunn SK,Ficker AM,Murali B,Madhu M,Gutstein DE,Fishman GI,Barrio LC,Cancelas JA

Tue Jun 05 00:00:00 EDT 2012

p85β phosphoinositide 3-kinase subunit regulates tumor progression.

Proceedings of the National Academy of Sciences of the United States of America

Cortés I,Sánchez-Ruíz J,Zuluaga S,Calvanese V,Marqués M,Hernández C,Rivera T,Kremer L,González-García A,Carrera AC

Tue Jul 10 00:00:00 EDT 2012

Early ontogenic origin of the hematopoietic stem cell lineage.

Proceedings of the National Academy of Sciences of the United States of America

Tanaka Y,Hayashi M,Kubota Y,Nagai H,Sheng G,Nishikawa S,Samokhvalov IM

Tue Mar 20 00:00:00 EDT 2012

Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Zandi S,Ahsberg J,Tsapogas P,Stjernberg J,Qian H,Sigvardsson M

Tue Sep 25 00:00:00 EDT 2012

Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.

Proceedings of the National Academy of Sciences of the United States of America

Guo S,Bai H,Megyola CM,Halene S,Krause DS,Scadden DT,Lu J

Tue Oct 09 00:00:00 EDT 2012

Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis.

Proceedings of the National Academy of Sciences of the United States of America

Oyoshi MK,He R,Kanaoka Y,ElKhal A,Kawamoto S,Lewis CN,Austen KF,Geha RS

Tue Mar 27 00:00:00 EDT 2012

Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses.

Proceedings of the National Academy of Sciences of the United States of America

Purtha WE,Swiecki M,Colonna M,Diamond MS,Bhattacharya D

Tue Apr 10 00:00:00 EDT 2012

Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.

Proceedings of the National Academy of Sciences of the United States of America

Cunningham L,Finckbeiner S,Hyde RK,Southall N,Marugan J,Yedavalli VR,Dehdashti SJ,Reinhold WC,Alemu L,Zhao L,Yeh JR,Sood R,Pommier Y,Austin CP,Jeang KT,Zheng W,Liu P

Tue Sep 04 00:00:00 EDT 2012

Induced transgene expression for the treatment of solid tumors by hematopoietic stem cell-based gene therapy.

Cancer gene therapy

Noyan F,Díez IA,Hapke M,Klein C,Dewey RA

Tue May 01 00:00:00 EDT 2012

Direct Toll-like receptor-mediated stimulation of hematopoietic stem and progenitor cells occurs in vivo and promotes differentiation toward macrophages.

Stem cells (Dayton, Ohio)

Megías J,Yáñez A,Moriano S,O'Connor JE,Gozalbo D,Gil ML

Sun Jul 01 00:00:00 EDT 2012

Self-renewal of leukemia stem cells in Friend virus-induced erythroleukemia requires proviral insertional activation of Spi1 and hedgehog signaling but not mutation of p53.

Stem cells (Dayton, Ohio)

Hegde S,Hankey P,Paulson RF

Wed Feb 01 00:00:00 EST 2012

Amniotic fluid stem cells restore the muscle cell niche in a HSA-Cre, Smn(F7/F7) mouse model.

Stem cells (Dayton, Ohio)

Piccoli M,Franzin C,Bertin E,Urbani L,Blaauw B,Repele A,Taschin E,Cenedese A,Zanon GF,André-Schmutz I,Rosato A,Melki J,Cavazzana-Calvo M,Pozzobon M,De Coppi P

Wed Aug 01 00:00:00 EDT 2012

The FcRβ- and γ-ITAMs play crucial but distinct roles in the full activation of mast cells induced by IgEκ and Protein L.

Journal of immunology (Baltimore, Md. : 1950)

Nunomura S,Kawakami Y,Kawakami T,Ra C

Sun Apr 15 00:00:00 EDT 2012

Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.

Journal of immunology (Baltimore, Md. : 1950)

Suzukawa M,Morita H,Nambu A,Arae K,Shimura E,Shibui A,Yamaguchi S,Suzukawa K,Nakanishi W,Oboki K,Kajiwara N,Ohno T,Ishii A,Körner H,Cua DJ,Suto H,Yoshimoto T,Iwakura Y,Yamasoba T,Ohta K,Sudo K,Saito H,Okumura K,Broide DH,Matsumoto K,Nakae S

Mon Oct 01 00:00:00 EDT 2012

NLRP3 inflammasome activity is negatively controlled by miR-223.

Journal of immunology (Baltimore, Md. : 1950)

Bauernfeind F,Rieger A,Schildberg FA,Knolle PA,Schmid-Burgk JL,Hornung V

Mon Oct 15 00:00:00 EDT 2012

Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.

Journal of immunology (Baltimore, Md. : 1950)

Xu LS,Sokalski KM,Hotke K,Christie DA,Zarnett O,Piskorz J,Thillainadesan G,Torchia J,DeKoter RP

Mon Oct 01 00:00:00 EDT 2012

The SWI/SNF-like BAF complex is essential for early B cell development.

Journal of immunology (Baltimore, Md. : 1950)

Choi J,Ko M,Jeon S,Jeon Y,Park K,Lee C,Lee H,Seong RH

Sun Apr 15 00:00:00 EDT 2012

Regulation of eosinophil trafficking by SWAP-70 and its role in allergic airway inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Bahaie NS,Hosseinkhani MR,Ge XN,Kang BN,Ha SG,Blumenthal MS,Jessberger R,Rao SP,Sriramarao P

Wed Feb 01 00:00:00 EST 2012

Stem cell factor programs the mast cell activation phenotype.

Journal of immunology (Baltimore, Md. : 1950)

Ito T,Smrž D,Jung MY,Bandara G,Desai A,Smržová Š,Kuehn HS,Beaven MA,Metcalfe DD,Gilfillan AM

Fri Jun 01 00:00:00 EDT 2012

Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.

Journal of immunology (Baltimore, Md. : 1950)

Shen S,Manser T

Sun Jan 01 00:00:00 EST 2012

CD11c+ cells are required for antigen-induced increase of mast cells in the lung.

Journal of immunology (Baltimore, Md. : 1950)

Dahlin JS,Feinstein R,Cui Y,Heyman B,Hallgren J

Mon Oct 15 00:00:00 EDT 2012

Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice.

Evidence-based complementary and alternative medicine : eCAM

Wang X,Kageyama-Yahara N,Hayashi S,Yamamoto T,Kadowaki M

Thu Aug 23 00:00:00 EDT 2012

Tcf7 is an important regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line.

PLoS genetics

Wu JQ,Seay M,Schulz VP,Hariharan M,Tuck D,Lian J,Du J,Shi M,Ye Z,Gerstein M,Snyder MP,Weissman S

Tue Sep 04 00:00:00 EDT 2012

Interleukin-33 primes mast cells for activation by IgG immune complexes.

PloS one

Kaieda S,Wang JX,Shnayder R,Fishgal N,Hei H,Lee RT,Stevens RL,Nigrovic PA

Thu Apr 04 00:00:00 EDT 2013

Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.

The Journal of biological chemistry

Pullen NA,Barnstein BO,Falanga YT,Wang Z,Suzuki R,Tamang TD,Khurana MC,Harry EA,Draber P,Bunting KD,Mizuno K,Wilson BS,Ryan JJ

Fri Jan 13 00:00:00 EST 2012

The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development.

PloS one

Laranjeiro R,Alcobia I,Neves H,Gomes AC,Saavedra P,Carvalho CC,Duarte A,Cidadão A,Parreira L

Thu Aug 30 00:00:00 EDT 2012

Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections.

Nature communications

Matsumura T,Ato M,Ikebe T,Ohnishi M,Watanabe H,Kobayashi K

Tue Feb 14 00:00:00 EST 2012

TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms.

PloS one

Takaesu G,Inagaki M,Takubo K,Mishina Y,Hess PR,Dean GA,Yoshimura A,Matsumoto K,Suda T,Ninomiya-Tsuji J

Tue May 28 00:00:00 EDT 2013

Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.

PloS one

Nakamura S,Oshima M,Yuan J,Saraya A,Miyagi S,Konuma T,Yamazaki S,Osawa M,Nakauchi H,Koseki H,Iwama A

Tue Oct 16 00:00:00 EDT 2012

Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms.

The Journal of biological chemistry

Hu P,Carlesso N,Xu M,Liu Y,Nebreda AR,Takemoto C,Kapur R

Fri Jun 08 00:00:00 EDT 2012

Transcription factor NF-κB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions.

The Journal of biological chemistry

Eylenstein A,Schmidt S,Gu S,Yang W,Schmid E,Schmidt EM,Alesutan I,Szteyn K,Regel I,Shumilina E,Lang F

Fri Jan 20 00:00:00 EST 2012

The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells.

PloS one

Yamada T,Park CS,Burns A,Nakada D,Lacorazza HD

Mon Oct 22 00:00:00 EDT 2012

FcεR1-mediated mast cell reactivity is amplified through prolonged Toll-like receptor-ligand treatment.

PloS one

Saluja R,Delin I,Nilsson GP,Adner M

Wed Jan 16 00:00:00 EST 2013

Defining the molecular role of gp91phox in the immune manifestation of acute allergic asthma using a preclinical murine model.

Clinical and molecular allergy : CMA

Banerjee ER,Henderson WR

Wed Jan 04 00:00:00 EST 2012

IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro.

PloS one

Heller NM,Gwinn WM,Donnelly RP,Constant SL,Keegan AD

Fri Jan 04 00:00:00 EST 2013

A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo.

PloS one

Dahlke C,Maul K,Christalla T,Walz N,Schult P,Stocking C,Grundhoff A

Wed May 22 00:00:00 EDT 2013

Induction of histiocytic sarcoma in mouse skeletal muscle.

PloS one

Liu J,Hettmer S,Milsom MD,Hofmann I,Hua F,Miller C,Bronson RT,Wagers AJ

Thu Feb 07 00:00:00 EST 2013

The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression.

The Journal of biological chemistry

Haining EJ,Yang J,Bailey RL,Khan K,Collier R,Tsai S,Watson SP,Frampton J,Garcia P,Tomlinson MG

Fri Nov 16 00:00:00 EST 2012

Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.

PloS one

Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H

Wed Jan 16 00:00:00 EST 2013

Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.

PloS one

Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H

Wed Jan 16 00:00:00 EST 2013

Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.

Cancer cell

Mazzieri R,Pucci F,Moi D,Zonari E,Ranghetti A,Berti A,Politi LS,Gentner B,Brown JL,Naldini L,De Palma M

Tue Apr 12 00:00:00 EDT 2011

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.

Cancer cell

Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R

Tue Sep 13 00:00:00 EDT 2011

Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment.

Blood

Singbrant S,Russell MR,Jovic T,Liddicoat B,Izon DJ,Purton LE,Sims NA,Martin TJ,Sankaran VG,Walkley CR

Thu May 26 00:00:00 EDT 2011

Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation.

Blood

Mazharian A,Ghevaert C,Zhang L,Massberg S,Watson SP

Thu May 12 00:00:00 EDT 2011

Macrophage development from HSCs requires PU.1-coordinated microRNA expression.

Blood

Ghani S,Riemke P,Schönheit J,Lenze D,Stumm J,Hoogenkamp M,Lagendijk A,Heinz S,Bonifer C,Bakkers J,Abdelilah-Seyfried S,Hummel M,Rosenbauer F

Thu Aug 25 00:00:00 EDT 2011

HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal.

Blood

Flygare J,Rayon Estrada V,Shin C,Gupta S,Lodish HF

Thu Mar 24 00:00:00 EDT 2011

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis.

Blood

Nguyen AT,Taranova O,He J,Zhang Y

Thu Jun 23 00:00:00 EDT 2011

PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability.

Blood

Furumoto Y,Charles N,Olivera A,Leung WH,Dillahunt S,Sargent JL,Tinsley K,Odom S,Scott E,Wilson TM,Ghoreschi K,Kneilling M,Chen M,Lee DM,Bolland S,Rivera J

Thu Nov 17 00:00:00 EST 2011

Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.

Blood

Maetzig T,Brugman MH,Bartels S,Heinz N,Kustikova OS,Modlich U,Li Z,Galla M,Schiedlmeier B,Schambach A,Baum C

Thu Mar 17 00:00:00 EDT 2011

Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.

Blood

Welch JS,Klco JM,Varghese N,Nagarajan R,Ley TJ

Thu Feb 24 00:00:00 EST 2011

Specificity for the tumor-associated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination.

Blood

Pospori C,Xue SA,Holler A,Voisine C,Perro M,King J,Fallah-Arani F,Flutter B,Chakraverty R,Stauss HJ,Morris EC

Thu Jun 23 00:00:00 EDT 2011

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.

Blood

Cornejo MG,Mabialah V,Sykes SM,Khandan T,Lo Celso C,Lopez CK,Rivera-Muñoz P,Rameau P,Tothova Z,Aster JC,DePinho RA,Scadden DT,Gilliland DG,Mercher T

Thu Aug 04 00:00:00 EDT 2011

Modulation of TGF-β signaling by endoglin in murine hemangioblast development and primitive hematopoiesis.

Blood

Zhang L,Magli A,Catanese J,Xu Z,Kyba M,Perlingeiro RC

Thu Jul 07 00:00:00 EDT 2011

Identification of Flt3⁺CD150⁻ myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential.

Blood

Chi AW,Chavez A,Xu L,Weber BN,Shestova O,Schaffer A,Wertheim G,Pear WS,Izon D,Bhandoola A

Thu Sep 08 00:00:00 EDT 2011

Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.

Blood

Chen TH,Kambal A,Krysiak K,Walshauser MA,Raju G,Tibbitts JF,Walter MJ

Thu Feb 03 00:00:00 EST 2011

Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.

Blood

Aue G,Du Y,Cleveland SM,Smith SB,Davé UP,Liu D,Weniger MA,Metais JY,Jenkins NA,Copeland NG,Dunbar CE

Thu Oct 27 00:00:00 EDT 2011

IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors.

Blood

Tsapogas P,Zandi S,Åhsberg J,Zetterblad J,Welinder E,Jönsson JI,Månsson R,Qian H,Sigvardsson M

Thu Aug 04 00:00:00 EDT 2011

E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction.

Blood

Yang Q,Esplin B,Borghesi L

Thu Mar 31 00:00:00 EDT 2011

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.

Blood

Ma P,Mali RS,Munugalavadla V,Krishnan S,Ramdas B,Sims E,Martin H,Ghosh J,Li S,Chan RJ,Krystal G,Craig AW,Takemoto C,Kapur R

Thu Sep 29 00:00:00 EDT 2011

Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.

Blood

Jaako P,Flygare J,Olsson K,Quere R,Ehinger M,Henson A,Ellis S,Schambach A,Baum C,Richter J,Larsson J,Bryder D,Karlsson S

Thu Dec 01 00:00:00 EST 2011

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.

Blood

Kharazi S,Mead AJ,Mansour A,Hultquist A,Böiers C,Luc S,Buza-Vidas N,Ma Z,Ferry H,Atkinson D,Reckzeh K,Masson K,Cammenga J,Rönnstrand L,Arai F,Suda T,Nerlov C,Sitnicka E,Jacobsen SE

Thu Sep 29 00:00:00 EDT 2011

AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.

Blood

Steffen B,Knop M,Bergholz U,Vakhrusheva O,Rode M,Köhler G,Henrichs MP,Bulk E,Hehn S,Stehling M,Dugas M,Bäumer N,Tschanter P,Brandts C,Koschmieder S,Berdel WE,Serve H,Stocking C,Müller-Tidow C

Thu Apr 21 00:00:00 EDT 2011

Δ12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice.

Blood

Hegde S,Kaushal N,Ravindra KC,Chiaro C,Hafer KT,Gandhi UH,Thompson JT,van den Heuvel JP,Kennett MJ,Hankey P,Paulson RF,Prabhu KS

Thu Dec 22 00:00:00 EST 2011

The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal.

Blood

Wang J,Han F,Wu J,Lee SW,Chan CH,Wu CY,Yang WL,Gao Y,Zhang X,Jeong YS,Moten A,Samaniego F,Huang P,Liu Q,Zeng YX,Lin HK

Thu Nov 17 00:00:00 EST 2011

SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis.

Blood

Zhang L,Friedman AD

Thu Aug 25 00:00:00 EDT 2011

In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors.

Blood

Richie Ehrlich LI,Serwold T,Weissman IL

Thu Mar 03 00:00:00 EST 2011

Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.

Blood

Sakata-Yanagimoto M,Sakai T,Miyake Y,Saito TI,Maruyama H,Morishita Y,Nakagami-Yamaguchi E,Kumano K,Yagita H,Fukayama M,Ogawa S,Kurokawa M,Yasutomo K,Chiba S

Thu Jan 06 00:00:00 EST 2011

A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo.

Blood

McGrath KE,Frame JM,Fromm GJ,Koniski AD,Kingsley PD,Little J,Bulger M,Palis J

Thu Apr 28 00:00:00 EDT 2011

Activation of the unfolded protein response is associated with impaired granulopoiesis in transgenic mice expressing mutant Elane.

Blood

Nanua S,Murakami M,Xia J,Grenda DS,Woloszynek J,Strand M,Link DC

Thu Mar 31 00:00:00 EDT 2011

Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus.

Blood

England SJ,McGrath KE,Frame JM,Palis J

Thu Mar 03 00:00:00 EST 2011

Correction of murine β-thalassemia after minimal lentiviral gene transfer and homeostatic in vivo erythroid expansion.

Blood

Negre O,Fusil F,Colomb C,Roth S,Gillet-Legrand B,Henri A,Beuzard Y,Bushman F,Leboulch P,Payen E

Thu May 19 00:00:00 EDT 2011

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.

Blood

Chan G,Cheung LS,Yang W,Milyavsky M,Sanders AD,Gu S,Hong WX,Liu AX,Wang X,Barbara M,Sharma T,Gavin J,Kutok JL,Iscove NN,Shannon KM,Dick JE,Neel BG,Braun BS

Thu Apr 21 00:00:00 EDT 2011

Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution.

Blood

Li N,Matte-Martone C,Zheng H,Cui W,Venkatesan S,Tan HS,McNiff J,Demetris AJ,Roopenian D,Kaech S,Shlomchik WD

Thu Nov 24 00:00:00 EST 2011

Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis.

The Journal of clinical investigation

Kreisel D,Sugimoto S,Tietjens J,Zhu J,Yamamoto S,Krupnick AS,Carmody RJ,Gelman AE

Sat Jan 01 00:00:00 EST 2011

CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice.

The Journal of clinical investigation

Weber C,Meiler S,Döring Y,Koch M,Drechsler M,Megens RT,Rowinska Z,Bidzhekov K,Fecher C,Ribechini E,van Zandvoort MA,Binder CJ,Jelinek I,Hristov M,Boon L,Jung S,Korn T,Lutz MB,Förster I,Zenke M,Hieronymus T,Junt T,Zernecke A

Fri Jul 01 00:00:00 EDT 2011

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.

The Journal of experimental medicine

Heltemes-Harris LM,Willette MJ,Ramsey LB,Qiu YH,Neeley ES,Zhang N,Thomas DA,Koeuth T,Baechler EC,Kornblau SM,Farrar MA

Mon Jun 06 00:00:00 EDT 2011

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia.

The Journal of experimental medicine

Hurtz C,Hatzi K,Cerchietti L,Braig M,Park E,Kim YM,Herzog S,Ramezani-Rad P,Jumaa H,Müller MC,Hofmann WK,Hochhaus A,Ye BH,Agarwal A,Druker BJ,Shah NP,Melnick AM,Müschen M

Mon Oct 24 00:00:00 EDT 2011

Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region.

The Journal of experimental medicine

Rybtsov S,Sobiesiak M,Taoudi S,Souilhol C,Senserrich J,Liakhovitskaia A,Ivanovs A,Frampton J,Zhao S,Medvinsky A

Mon Jun 06 00:00:00 EDT 2011

Complex interactions in EML cell stimulation by stem cell factor and IL-3.

Proceedings of the National Academy of Sciences of the United States of America

Ye ZJ,Gulcicek E,Stone K,Lam T,Schulz V,Weissman SM

Tue Mar 22 00:00:00 EDT 2011

Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus.

Proceedings of the National Academy of Sciences of the United States of America

Calderón L,Boehm T

Tue May 03 00:00:00 EDT 2011

Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events.

Stem cells (Dayton, Ohio)

Heffner GC,Clutter MR,Nolan GP,Weissman IL

Tue Nov 01 00:00:00 EDT 2011

Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Luna-Gomes T,Magalhães KG,Mesquita-Santos FP,Bakker-Abreu I,Samico RF,Molinaro R,Calheiros AS,Diaz BL,Bozza PT,Weller PF,Bandeira-Melo C

Thu Dec 15 00:00:00 EST 2011

Ets-1 maintains IL-7 receptor expression in peripheral T cells.

Journal of immunology (Baltimore, Md. : 1950)

Grenningloh R,Tai TS,Frahm N,Hongo TC,Chicoine AT,Brander C,Kaufmann DE,Ho IC

Sat Jan 15 00:00:00 EST 2011

STIM1-directed reorganization of microtubules in activated mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Hájková Z,Bugajev V,Dráberová E,Vinopal S,Dráberová L,Janáček J,Dráber P,Dráber P

Sat Jan 15 00:00:00 EST 2011

Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Cantor J,Slepak M,Ege N,Chang JT,Ginsberg MH

Fri Jul 15 00:00:00 EDT 2011

Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression.

Journal of immunology (Baltimore, Md. : 1950)

Li H,Nourbakhsh B,Safavi F,Li K,Xu H,Cullimore M,Zhou F,Zhang G,Rostami A

Fri Jul 01 00:00:00 EDT 2011

SIRPα/CD172a regulates eosinophil homeostasis.

Journal of immunology (Baltimore, Md. : 1950)

Verjan Garcia N,Umemoto E,Saito Y,Yamasaki M,Hata E,Matozaki T,Murakami M,Jung YJ,Woo SY,Seoh JY,Jang MH,Aozasa K,Miyasaka M

Thu Sep 01 00:00:00 EDT 2011

Mast cell-derived IL-10 suppresses germinal center formation by affecting T follicular helper cell function.

Journal of immunology (Baltimore, Md. : 1950)

Chacón-Salinas R,Limón-Flores AY,Chávez-Blanco AD,Gonzalez-Estrada A,Ullrich SE

Sat Jan 01 00:00:00 EST 2011

Graft-versus-leukemia (GVL) against mouse blast-crisis chronic myelogenous leukemia (BC-CML) and chronic-phase chronic myelogenous leukemia (CP-CML): shared mechanisms of T cell killing, but programmed death ligands render CP-CML and not BC-CML GVL resistant.

Journal of immunology (Baltimore, Md. : 1950)

Matte-Martone C,Venkatesan S,Tan HS,Athanasiadis I,Chang J,Pavisic J,Shlomchik WD

Mon Aug 15 00:00:00 EDT 2011

Parasitic infection improves survival from septic peritonitis by enhancing mast cell responses to bacteria in mice.

PloS one

Sutherland RE,Xu X,Kim SS,Seeley EJ,Caughey GH,Wolters PJ

Mon Mar 26 00:00:00 EDT 2012

Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.

The Journal of biological chemistry

Guo H,Friedman AD

Fri Jan 07 00:00:00 EST 2011

Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis.

BMC genomics

Dutta P,Koch A,Breyer B,Schneider H,Dittrich-Breiholz O,Kracht M,Tamura T

Mon Apr 18 00:00:00 EDT 2011

Immuno-therapy with anti-CTLA4 antibodies in tolerized and non-tolerized mouse tumor models.

PloS one

Persson J,Beyer I,Yumul R,Li Z,Kiem HP,Roffler S,Lieber A

Tue Nov 15 00:00:00 EST 2011

Candida albicans induces selective development of macrophages and monocyte derived dendritic cells by a TLR2 dependent signalling.

PloS one

Yáñez A,Megías J,O'Connor JE,Gozalbo D,Gil ML

Tue Feb 28 00:00:00 EST 2012

ISG15 modulates development of the erythroid lineage.

PloS one

Maragno AL,Pironin M,Alcalde H,Cong X,Knobeloch KP,Tangy F,Zhang DE,Ghysdael J,Quang CT

Fri Feb 17 00:00:00 EST 2012

MiR-221 influences effector functions and actin cytoskeleton in mast cells.

PloS one

Mayoral RJ,Deho L,Rusca N,Bartonicek N,Saini HK,Enright AJ,Monticelli S

Fri Feb 17 00:00:00 EST 2012

Triple selectin knockout (ELP-/-) mice fail to develop OVA-induced acute asthma phenotype.

Journal of inflammation (London, England)

Banerjee ER

Thu Aug 11 00:00:00 EDT 2011

Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3.

The Journal of biological chemistry

Liu Z,Yang A,Wang Z,Bunting KD,Davuluri G,Green MR,Devireddy LR

Fri Jun 10 00:00:00 EDT 2011

Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity.

PloS one

Otsuka A,Kubo M,Honda T,Egawa G,Nakajima S,Tanizaki H,Kim B,Matsuoka S,Watanabe T,Nakae S,Miyachi Y,Kabashima K

Thu Jan 26 00:00:00 EST 2012

Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.

The Journal of biological chemistry

Dagälv A,Holmborn K,Kjellén L,Abrink M

Fri Dec 30 00:00:00 EST 2011

Magnetic resonance imaging of bone marrow cell-mediated interleukin-10 gene therapy of atherosclerosis.

PloS one

Sun J,Li X,Feng H,Gu H,Blair T,Li J,Soriano S,Meng Y,Zhang F,Feng Q,Yang X

Tue Feb 14 00:00:00 EST 2012

IgE immune complexes stimulate an increase in lung mast cell progenitors in a mouse model of allergic airway inflammation.

PloS one

Dahlin JS,Ivarsson MA,Heyman B,Hallgren J

Mon Oct 17 00:00:00 EDT 2011

Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis.

BMC immunology

Arumugam M,Ahrens R,Osterfeld H,Kottyan LC,Shang X,Maclennan JA,Zimmermann N,Zheng Y,Finkelman FD,Hogan SP

Thu Feb 03 00:00:00 EST 2011

Stem cell factor and granulocyte colony-stimulating factor reduce β-amyloid deposits in the brains of APP/PS1 transgenic mice.

Alzheimer's research & therapy

Li B,Gonzalez-Toledo ME,Piao CS,Gu A,Kelley RE,Zhao LR

Tue Mar 15 00:00:00 EDT 2011

Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils.

PloS one

Zhang J,Alcaide P,Liu L,Sun J,He A,Luscinskas FW,Shi GP

Fri Jan 14 00:00:00 EST 2011

Differential Secondary Reconstitution of In Vivo-Selected Human SCID-Repopulating Cells in NOD/SCID versus NOD/SCID/γ chain Mice.

Bone marrow research

Cai S,Wang H,Bailey B,Hartwell JR,Silver JM,Juliar BE,Sinn AL,Baluyut AR,Pollok KE

Thu Nov 10 00:00:00 EST 2011

Single cell analysis facilitates staging of Blimp1-dependent primordial germ cells derived from mouse embryonic stem cells.

PloS one

Vincent JJ,Li Z,Lee SA,Liu X,Etter MO,Diaz-Perez SV,Taylor SK,Gkountela S,Lindgren AG,Clark AT

Mon Aug 27 00:00:00 EDT 2012

Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells.

The Journal of biological chemistry

Chaix A,Lopez S,Voisset E,Gros L,Dubreuil P,De Sepulveda P

Fri Feb 25 00:00:00 EST 2011

Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway.

PloS one

Heinonen KM,Vanegas JR,Lew D,Krosl J,Perreault C

Tue Apr 26 00:00:00 EDT 2011

Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations.

The Journal of biological chemistry

Nörenberg W,Hempel C,Urban N,Sobottka H,Illes P,Schaefer M

Fri Apr 01 00:00:00 EDT 2011

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.

Nature

Nakada D,Saunders TL,Morrison SJ

Thu Dec 02 00:00:00 EST 2010

A reprogrammable mouse strain from gene-targeted embryonic stem cells.

Nature methods

Stadtfeld M,Maherali N,Borkent M,Hochedlinger K

Fri Jan 01 00:00:00 EST 2010

Single-gene transgenic mouse strains for reprogramming adult somatic cells.

Nature methods

Carey BW,Markoulaki S,Beard C,Hanna J,Jaenisch R

Fri Jan 01 00:00:00 EST 2010

Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes.

Immunity

Vonarbourg C,Mortha A,Bui VL,Hernandez PP,Kiss EA,Hoyler T,Flach M,Bengsch B,Thimme R,Hölscher C,Hönig M,Pannicke U,Schwarz K,Ware CF,Finke D,Diefenbach A

Wed Nov 24 00:00:00 EST 2010

β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.

Cancer cell

Yeung J,Esposito MT,Gandillet A,Zeisig BB,Griessinger E,Bonnet D,So CW

Tue Dec 14 00:00:00 EST 2010

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.

Blood

Keeshan K,Bailis W,Dedhia PH,Vega ME,Shestova O,Xu L,Toscano K,Uljon SN,Blacklow SC,Pear WS

Thu Dec 02 00:00:00 EST 2010

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.

Blood

Keeshan K,Bailis W,Dedhia PH,Vega ME,Shestova O,Xu L,Toscano K,Uljon SN,Blacklow SC,Pear WS

Thu Dec 02 00:00:00 EST 2010

Hematopoietic progenitor cell regulation by CD4+CD25+ T cells.

Blood

Urbieta M,Barao I,Jones M,Jurecic R,Panoskaltsis-Mortari A,Blazar BR,Murphy WJ,Levy RB

Thu Jun 10 00:00:00 EDT 2010

Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.

Blood

Qiu JJ,Lu X,Zeisig BB,Ma Z,Cai X,Chen S,Gronemeyer H,Tweardy DJ,So CW,Dong S

Thu Jan 21 00:00:00 EST 2010

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.

Blood

Dedhia PH,Keeshan K,Uljon S,Xu L,Vega ME,Shestova O,Zaks-Zilberman M,Romany C,Blacklow SC,Pear WS

Thu Aug 26 00:00:00 EDT 2010

Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.

Blood

Chessa TA,Anderson KE,Hu Y,Xu Q,Rausch O,Stephens LR,Hawkins PT

Thu Dec 23 00:00:00 EST 2010

During EPO or anemia challenge, erythroid progenitor cells transit through a selectively expandable proerythroblast pool.

Blood

Dev A,Fang J,Sathyanarayana P,Pradeep A,Emerson C,Wojchowski DM

Thu Dec 09 00:00:00 EST 2010

Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.

Blood

Nozad Charoudeh H,Tang Y,Cheng M,Cilio CM,Jacobsen SE,Sitnicka E

Thu Jul 15 00:00:00 EDT 2010

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells.

Blood

Hosokawa K,Arai F,Yoshihara H,Iwasaki H,Nakamura Y,Gomei Y,Suda T

Thu Jul 29 00:00:00 EDT 2010

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.

Blood

Juntilla MM,Patil VD,Calamito M,Joshi RP,Birnbaum MJ,Koretzky GA

Thu May 20 00:00:00 EDT 2010

B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.

Blood

Kerns HM,Ryu BY,Stirling BV,Sather BD,Astrakhan A,Humblet-Baron S,Liggitt D,Rawlings DJ

Thu Mar 18 00:00:00 EDT 2010

Essential role for focal adhesion kinase in regulating stress hematopoiesis.

Blood

Vemula S,Ramdas B,Hanneman P,Martin J,Beggs HE,Kapur R

Thu Nov 18 00:00:00 EST 2010

Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model.

Blood

Agrawal-Singh S,Koschmieder S,Gelsing S,Stocking C,Stehling M,Thiede C,Thoennissen NH,Köhler G,Valk PJ,Delwel R,Mills K,Bäumer N,Tickenbrock L,Hansen K,Berdel WE,Müller-Tidow C,Serve H

Thu Jun 03 00:00:00 EDT 2010

W41/W41 blastocyst complementation: a system for genetic modeling of hematopoiesis.

Blood

Jansson L,Larsson J

Thu Jan 07 00:00:00 EST 2010

Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.

Blood

Böiers C,Buza-Vidas N,Jensen CT,Pronk CJ,Kharazi S,Wittmann L,Sitnicka E,Hultquist A,Jacobsen SE

Thu Jun 17 00:00:00 EDT 2010

Critical role of Src-Syk-PLC{gamma}2 signaling in megakaryocyte migration and thrombopoiesis.

Blood

Mazharian A,Thomas SG,Dhanjal TS,Buckley CD,Watson SP

Thu Aug 05 00:00:00 EDT 2010

A key role for ATF3 in regulating mast cell survival and mediator release.

Blood

Gilchrist M,Henderson WR,Morotti A,Johnson CD,Nachman A,Schmitz F,Smith KD,Aderem A

Thu Jun 10 00:00:00 EDT 2010

Lineage-instructive function of C/EBPα in multipotent hematopoietic cells and early thymic progenitors.

Blood

Wölfler A,Danen-van Oorschot AA,Haanstra JR,Valkhof M,Bodner C,Vroegindeweij E,van Strien P,Novak A,Cupedo T,Touw IP

Thu Nov 18 00:00:00 EST 2010

The transcription factor Srf regulates hematopoietic stem cell adhesion.

Blood

Ragu C,Elain G,Mylonas E,Ottolenghi C,Cagnard N,Daegelen D,Passegué E,Vainchenker W,Bernard OA,Penard-Lacronique V

Thu Nov 25 00:00:00 EST 2010

The transcription factor Srf regulates hematopoietic stem cell adhesion.

Blood

Ragu C,Elain G,Mylonas E,Ottolenghi C,Cagnard N,Daegelen D,Passegué E,Vainchenker W,Bernard OA,Penard-Lacronique V

Thu Nov 25 00:00:00 EST 2010

Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation.

Blood

Starck J,Weiss-Gayet M,Gonnet C,Guyot B,Vicat JM,Morlé F

Thu Dec 02 00:00:00 EST 2010

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia.

Blood

Li J,Spensberger D,Ahn JS,Anand S,Beer PA,Ghevaert C,Chen E,Forrai A,Scott LM,Ferreira R,Campbell PJ,Watson SP,Liu P,Erber WN,Huntly BJ,Ottersbach K,Green AR

Thu Sep 02 00:00:00 EDT 2010

Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.

Blood

Pulliam-Leath AC,Ciccone SL,Nalepa G,Li X,Si Y,Miravalle L,Smith D,Yuan J,Li J,Anur P,Orazi A,Vance GH,Yang FC,Hanenberg H,Bagby GC,Clapp DW

Thu Oct 21 00:00:00 EDT 2010

Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma.

Blood

de Bruin AM,Buitenhuis M,van der Sluijs KF,van Gisbergen KP,Boon L,Nolte MA

Thu Oct 07 00:00:00 EDT 2010

STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.

Blood

Li G,Miskimen KL,Wang Z,Xie XY,Brenzovich J,Ryan JJ,Tse W,Moriggl R,Bunting KD

Thu Feb 18 00:00:00 EST 2010

Early mammalian erythropoiesis requires the Dot1L methyltransferase.

Blood

Feng Y,Yang Y,Ortega MM,Copeland JN,Zhang M,Jacob JB,Fields TA,Vivian JL,Fields PE

Thu Nov 25 00:00:00 EST 2010

Leukemogenic transformation by HOXA cluster genes.

Blood

Bach C,Buhl S,Mueller D,García-Cuéllar MP,Maethner E,Slany RK

Thu Apr 08 00:00:00 EDT 2010

Lnk constrains myeloproliferative diseases in mice.

The Journal of clinical investigation

Bersenev A,Wu C,Balcerek J,Jing J,Kundu M,Blobel GA,Chikwava KR,Tong W

Tue Jun 01 00:00:00 EDT 2010

CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice.

The Journal of clinical investigation

Si Y,Tsou CL,Croft K,Charo IF

Thu Apr 01 00:00:00 EDT 2010

Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.

The Journal of experimental medicine

Morita Y,Ema H,Nakauchi H

Mon Jun 07 00:00:00 EDT 2010

SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis.

The Journal of experimental medicine

Yu L,Ji W,Zhang H,Renda MJ,He Y,Lin S,Cheng EC,Chen H,Krause DS,Min W

Mon Jun 07 00:00:00 EDT 2010

A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.

The Journal of experimental medicine

Henderson RB,Grys K,Vehlow A,de Bettignies C,Zachacz A,Henley T,Turner M,Batista F,Tybulewicz VL

Mon Apr 12 00:00:00 EDT 2010

Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Chou S,Lodish HF

Tue Apr 27 00:00:00 EDT 2010

Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Naramura M,Nandwani N,Gu H,Band V,Band H

Tue Sep 14 00:00:00 EDT 2010

Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen.

Haematologica

Kalfa TA,Pushkaran S,Zhang X,Johnson JF,Pan D,Daria D,Geiger H,Cancelas JA,Williams DA,Zheng Y

Fri Jan 01 00:00:00 EST 2010

A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression.

PLoS biology

Pop R,Shearstone JR,Shen Q,Liu Y,Hallstrom K,Koulnis M,Gribnau J,Socolovsky M

Tue Sep 21 00:00:00 EDT 2010

Bone marrow-derived hematopoietic cells undergo myogenic differentiation following a Pax-7 independent pathway.

Stem cells (Dayton, Ohio)

Xynos A,Corbella P,Belmonte N,Zini R,Manfredini R,Ferrari G

Sat May 01 00:00:00 EDT 2010

Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells.

Stem cells (Dayton, Ohio)

Zhou Z,French DL,Ma G,Eisenstein S,Chen Y,Divino CM,Keller G,Chen SH,Pan PY

Wed Mar 31 00:00:00 EDT 2010

Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis.

Journal of immunology (Baltimore, Md. : 1950)

Scandiuzzi L,Beghdadi W,Daugas E,Abrink M,Tiwari N,Brochetta C,Claver J,Arouche N,Zang X,Pretolani M,Monteiro RC,Pejler G,Blank U

Thu Jul 01 00:00:00 EDT 2010

Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor.

Journal of immunology (Baltimore, Md. : 1950)

Dyer KD,Percopo CM,Xie Z,Yang Z,Kim JD,Davoine F,Lacy P,Druey KM,Moqbel R,Rosenberg HF

Tue Jun 01 00:00:00 EDT 2010

The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo.

Journal of immunology (Baltimore, Md. : 1950)

Collington SJ,Hallgren J,Pease JE,Jones TG,Rollins BJ,Westwick J,Austen KF,Williams TJ,Gurish MF,Weller CL

Tue Jun 01 00:00:00 EDT 2010

Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Alvarez-Errico D,Yamashita Y,Suzuki R,Odom S,Furumoto Y,Yamashita T,Rivera J

Sat May 01 00:00:00 EDT 2010

Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development.

Journal of immunology (Baltimore, Md. : 1950)

Chappaz S,Gärtner C,Rodewald HR,Finke D

Wed Sep 15 00:00:00 EDT 2010

TGF-beta1 accelerates dendritic cell differentiation from common dendritic cell progenitors and directs subset specification toward conventional dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Felker P,Seré K,Lin Q,Becker C,Hristov M,Hieronymus T,Zenke M

Mon Nov 01 00:00:00 EDT 2010

IL-33 induces IL-13-dependent cutaneous fibrosis.

Journal of immunology (Baltimore, Md. : 1950)

Rankin AL,Mumm JB,Murphy E,Turner S,Yu N,McClanahan TK,Bourne PA,Pierce RH,Kastelein R,Pflanz S

Mon Feb 01 00:00:00 EST 2010

Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.

Journal of immunotherapy (Hagerstown, Md. : 1997)

Wrzesinski C,Paulos CM,Kaiser A,Muranski P,Palmer DC,Gattinoni L,Yu Z,Rosenberg SA,Restifo NP

Fri Jan 01 00:00:00 EST 2010

Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis.

Cell death & disease

Karlberg M,Ekoff M,Labi V,Strasser A,Huang D,Nilsson G

Thu May 13 00:00:00 EDT 2010

Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model.

PloS one

Yang Z,Zhang B,Li D,Lv M,Huang C,Shen GX,Huang B

Wed Jan 27 00:00:00 EST 2010

Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils.

The Journal of biological chemistry

Zhang Y,Tang W,Jones MC,Xu W,Halene S,Wu D

Fri Aug 06 00:00:00 EDT 2010

Characterization of oxidative guanine damage and repair in mammalian telomeres.

PLoS genetics

Wang Z,Rhee DB,Lu J,Bohr CT,Zhou F,Vallabhaneni H,de Souza-Pinto NC,Liu Y

Thu May 13 00:00:00 EDT 2010

c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion.

The Journal of biological chemistry

Jiao X,Katiyar S,Willmarth NE,Liu M,Ma X,Flomenberg N,Lisanti MP,Pestell RG

Fri Mar 12 00:00:00 EST 2010

Serial bone marrow transplantation reveals in vivo expression of the pCLPG retroviral vector.

Virology journal

Fratini P,Strauss BE

Fri Jan 22 00:00:00 EST 2010

Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mast cells.

The Journal of biological chemistry

Ohtake-Niimi S,Kondo S,Ito T,Kakehi S,Ohta T,Habuchi H,Kimata K,Habuchi O

Fri Jul 02 00:00:00 EDT 2010

Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts.

The Journal of biological chemistry

Heneberg P,Dráberová L,Bambousková M,Pompach P,Dráber P

Fri Apr 23 00:00:00 EDT 2010

Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1).

The Journal of biological chemistry

Kaieda S,Shin K,Nigrovic PA,Seki K,Lee RT,Stevens RL,Lee DM

Fri Jul 09 00:00:00 EDT 2010

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease.

Nature

Gu Y,Harley IT,Henderson LB,Aronow BJ,Vietor I,Huber LA,Harley JB,Kilpatrick JR,Langefeld CD,Williams AH,Jegga AG,Chen J,Wills-Karp M,Arshad SH,Ewart SL,Thio CL,Flick LM,Filippi MD,Grimes HL,Drumm ML,Cutting GR,Knowles MR,Karp CL

Thu Apr 23 00:00:00 EDT 2009

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.

Nature

Yanai H,Ban T,Wang Z,Choi MK,Kawamura T,Negishi H,Nakasato M,Lu Y,Hangai S,Koshiba R,Savitsky D,Ronfani L,Akira S,Bianchi ME,Honda K,Tamura T,Kodama T,Taniguchi T

Thu Nov 05 00:00:00 EST 2009

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.

Nature

Viale A,De Franco F,Orleth A,Cambiaghi V,Giuliani V,Bossi D,Ronchini C,Ronzoni S,Muradore I,Monestiroli S,Gobbi A,Alcalay M,Minucci S,Pelicci PG

Thu Jan 01 00:00:00 EST 2009

A role for Lin28 in primordial germ-cell development and germ-cell malignancy.

Nature

West JA,Viswanathan SR,Yabuuchi A,Cunniff K,Takeuchi A,Park IH,Sero JE,Zhu H,Perez-Atayde A,Frazier AL,Surani MA,Daley GQ

Thu Aug 13 00:00:00 EDT 2009

Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.

Nature

Sanada M,Suzuki T,Shih LY,Otsu M,Kato M,Yamazaki S,Tamura A,Honda H,Sakata-Yanagimoto M,Kumano K,Oda H,Yamagata T,Takita J,Gotoh N,Nakazaki K,Kawamata N,Onodera M,Nobuyoshi M,Hayashi Y,Harada H,Kurokawa M,Chiba S,Mori H,Ozawa K,Omine M,Hirai H,Nakauchi H,Koeffler HP,Ogawa S

Thu Aug 13 00:00:00 EDT 2009

Direct cell reprogramming is a stochastic process amenable to acceleration.

Nature

Hanna J,Saha K,Pando B,van Zon J,Lengner CJ,Creyghton MP,van Oudenaarden A,Jaenisch R

Thu Dec 03 00:00:00 EST 2009

MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.

Cell

Sarrazin S,Mossadegh-Keller N,Fukao T,Aziz A,Mourcin F,Vanhille L,Kelly Modis L,Kastner P,Chan S,Duprez E,Otto C,Sieweke MH

Thu Jul 23 00:00:00 EDT 2009

Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c.

Nature immunology

Stehling-Sun S,Dade J,Nutt SL,DeKoter RP,Camargo FD

Sun Mar 01 00:00:00 EST 2009

Intraclonal competition limits the fate determination of regulatory T cells in the thymus.

Nature immunology

Bautista JL,Lio CW,Lathrop SK,Forbush K,Liang Y,Luo J,Rudensky AY,Hsieh CS

Mon Jun 01 00:00:00 EDT 2009

Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapy.

Blood

Laje P,Shang D,Cao W,Niiya M,Endo M,Radu A,DeRogatis N,Scheiflinger F,Zoltick PW,Flake AW,Zheng XL

Thu Mar 05 00:00:00 EST 2009

Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene.

Blood

Zhao H,Pestina TI,Nasimuzzaman M,Mehta P,Hargrove PW,Persons DA

Thu Jun 04 00:00:00 EDT 2009

Gfi1 integrates progenitor versus granulocytic transcriptional programming.

Blood

Horman SR,Velu CS,Chaubey A,Bourdeau T,Zhu J,Paul WE,Gebelein B,Grimes HL

Thu May 28 00:00:00 EDT 2009

Genetic deletion of JAM-C reveals a role in myeloid progenitor generation.

Blood

Praetor A,McBride JM,Chiu H,Rangell L,Cabote L,Lee WP,Cupp J,Danilenko DM,Fong S

Thu Feb 26 00:00:00 EST 2009

Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions.

Blood

Cochrane SW,Zhao Y,Welner RS,Sun XH

Thu Jan 29 00:00:00 EST 2009

Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo.

Blood

Li Y,Chen S,Yuan J,Yang Y,Li J,Ma J,Wu X,Freund M,Pollok K,Hanenberg H,Goebel WS,Yang FC

Thu Mar 05 00:00:00 EST 2009

Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.

Blood

Rice KL,Hormaeche I,Doulatov S,Flatow JM,Grimwade D,Mills KI,Leiva M,Ablain J,Ambardekar C,McConnell MJ,Dick JE,Licht JD

Thu Dec 24 00:00:00 EST 2009

E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.

Blood

Bandi SR,Brandts C,Rensinghoff M,Grundler R,Tickenbrock L,Köhler G,Duyster J,Berdel WE,Müller-Tidow C,Serve H,Sargin B

Thu Nov 05 00:00:00 EST 2009

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease.

Blood

King IL,Dickendesher TL,Segal BM

Thu Apr 02 00:00:00 EDT 2009

Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist.

Blood

Blue R,Kowalska MA,Hirsch J,Murcia M,Janczak CA,Harrington A,Jirouskova M,Li J,Fuentes R,Thornton MA,Filizola M,Poncz M,Coller BS

Thu Jul 02 00:00:00 EDT 2009

Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.

Blood

Kuo YH,Zaidi SK,Gornostaeva S,Komori T,Stein GS,Castilla LH

Thu Apr 02 00:00:00 EDT 2009

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.

Blood

Chan G,Kalaitzidis D,Usenko T,Kutok JL,Yang W,Mohi MG,Neel BG

Thu Apr 30 00:00:00 EDT 2009

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia.

Blood

Russell LJ,Capasso M,Vater I,Akasaka T,Bernard OA,Calasanz MJ,Chandrasekaran T,Chapiro E,Gesk S,Griffiths M,Guttery DS,Haferlach C,Harder L,Heidenreich O,Irving J,Kearney L,Nguyen-Khac F,Machado L,Minto L,Majid A,Moorman AV,Morrison H,Rand V,Strefford JC,Schwab C,Tönnies H,Dyer MJ,Siebert R,Harrison CJ

Thu Sep 24 00:00:00 EDT 2009

Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.

Blood

Gekas C,Rhodes KE,Gereige LM,Helgadottir H,Ferrari R,Kurdistani SK,Montecino-Rodriguez E,Bassel-Duby R,Olson E,Krivtsov AV,Armstrong S,Orkin SH,Pellegrini M,Mikkola HK

Thu Apr 09 00:00:00 EDT 2009

Distinct roles of stress-activated protein kinases in Fanconi anemia-type C-deficient hematopoiesis.

Blood

Saadatzadeh MR,Bijangi-Vishehsaraei K,Kapur R,Haneline LS

Thu Mar 19 00:00:00 EDT 2009

Negative regulation of activated alpha-2 integrins during thrombopoiesis.

Blood

Zou Z,Schmaier AA,Cheng L,Mericko P,Dickeson SK,Stricker TP,Santoro SA,Kahn ML

Thu Jun 18 00:00:00 EDT 2009

Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-induced leukemia model.

Blood

Hu X,Shen H,Tian C,Yu H,Zheng G,XuFeng R,Ju Z,Xu J,Wang J,Cheng T

Thu Oct 29 00:00:00 EDT 2009

Gfi1 regulates miR-21 and miR-196b to control myelopoiesis.

Blood

Velu CS,Baktula AM,Grimes HL

Thu May 07 00:00:00 EDT 2009

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.

Blood

Allen JD,Jaffer ZM,Park SJ,Burgin S,Hofmann C,Sells MA,Chen S,Derr-Yellin E,Michels EG,McDaniel A,Bessler WK,Ingram DA,Atkinson SJ,Travers JB,Chernoff J,Clapp DW

Thu Mar 19 00:00:00 EDT 2009

Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C.

Blood

Schwieger M,Schüler A,Forster M,Engelmann A,Arnold MA,Delwel R,Valk PJ,Löhler J,Slany RK,Olson EN,Stocking C

Thu Sep 17 00:00:00 EDT 2009

Critical role of class IA PI3K for c-Rel expression in B lymphocytes.

Blood

Matsuda S,Mikami Y,Ohtani M,Fujiwara M,Hirata Y,Minowa A,Terauchi Y,Kadowaki T,Koyasu S

Thu Jan 29 00:00:00 EST 2009

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.

Blood

Xu H,Eleswarapu S,Geiger H,Szczur K,Daria D,Zheng Y,Settleman J,Srour EF,Williams DA,Filippi MD

Thu Oct 22 00:00:00 EDT 2009

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities.

Blood

Horton SJ,Walf-Vorderwülbecke V,Chatters SJ,Sebire NJ,de Boer J,Williams O

Thu May 14 00:00:00 EDT 2009

Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6.

Blood

Dyer KD,Percopo CM,Fischer ER,Gabryszewski SJ,Rosenberg HF

Thu Sep 24 00:00:00 EDT 2009

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.

The Journal of clinical investigation

Montini E,Cesana D,Schmidt M,Sanvito F,Bartholomae CC,Ranzani M,Benedicenti F,Sergi LS,Ambrosi A,Ponzoni M,Doglioni C,Di Serio C,von Kalle C,Naldini L

Wed Apr 01 00:00:00 EDT 2009

Niche recycling through division-independent egress of hematopoietic stem cells.

The Journal of experimental medicine

Bhattacharya D,Czechowicz A,Ooi AG,Rossi DJ,Bryder D,Weissman IL

Mon Nov 23 00:00:00 EST 2009

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.

The Journal of experimental medicine

Fukui R,Saitoh S,Matsumoto F,Kozuka-Hata H,Oyama M,Tabeta K,Beutler B,Miyake K

Mon Jun 08 00:00:00 EDT 2009

MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells.

The EMBO journal

Schwermann J,Rathinam C,Schubert M,Schumacher S,Noyan F,Koseki H,Kotlyarov A,Klein C,Gaestel M

Wed May 20 00:00:00 EDT 2009

Self-inactivating retroviral vector-mediated gene transfer induces oncogene activation and immortalization of primary murine bone marrow cells.

Molecular therapy : the journal of the American Society of Gene Therapy

Bosticardo M,Ghosh A,Du Y,Jenkins NA,Copeland NG,Candotti F

Sun Nov 01 00:00:00 EDT 2009

Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin.

Molecular therapy : the journal of the American Society of Gene Therapy

Pestina TI,Hargrove PW,Jay D,Gray JT,Boyd KM,Persons DA

Sun Feb 01 00:00:00 EST 2009

ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.

Proceedings of the National Academy of Sciences of the United States of America

XuFeng R,Boyer MJ,Shen H,Li Y,Yu H,Gao Y,Yang Q,Wang Q,Cheng T

Tue Oct 20 00:00:00 EDT 2009

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.

Proceedings of the National Academy of Sciences of the United States of America

Schmaier AA,Zou Z,Kazlauskas A,Emert-Sedlak L,Fong KP,Neeves KB,Maloney SF,Diamond SL,Kunapuli SP,Ware J,Brass LF,Smithgall TE,Saksela K,Kahn ML

Tue Dec 15 00:00:00 EST 2009

Misguided transcriptional elongation causes mixed lineage leukemia.

PLoS biology

Mueller D,García-Cuéllar MP,Bach C,Buhl S,Maethner E,Slany RK

Sun Nov 01 00:00:00 EDT 2009

The role of stem cell factor and granulocyte-colony stimulating factor in brain repair during chronic stroke.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Piao CS,Gonzalez-Toledo ME,Xue YQ,Duan WM,Terao S,Granger DN,Kelley RE,Zhao LR

Wed Apr 01 00:00:00 EDT 2009

The adhesion molecule esam1 is a novel hematopoietic stem cell marker.

Stem cells (Dayton, Ohio)

Ooi AG,Karsunky H,Majeti R,Butz S,Vestweber D,Ishida T,Quertermous T,Weissman IL,Forsberg EC

Sun Mar 01 00:00:00 EST 2009

The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.

Stem cells (Dayton, Ohio)

Ogaeri T,Eto K,Otsu M,Ema H,Nakauchi H

Fri May 01 00:00:00 EDT 2009

A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency.

Journal of immunology (Baltimore, Md. : 1950)

Verhagen AM,Wallace ME,Goradia A,Jones SA,Croom HA,Metcalf D,Collinge JE,Maxwell MJ,Hibbs ML,Alexander WS,Hilton DJ,Kile BT,Starr R

Sun Feb 15 00:00:00 EST 2009

Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Kambayashi T,Allenspach EJ,Chang JT,Zou T,Shoag JE,Reiner SL,Caton AJ,Koretzky GA

Wed Apr 15 00:00:00 EDT 2009

FoxP3+ regulatory T cells restrain splenic extramedullary myelopoiesis via suppression of hemopoietic cytokine-producing T cells.

Journal of immunology (Baltimore, Md. : 1950)

Lee JH,Wang C,Kim CH

Sun Nov 15 00:00:00 EST 2009

c-Myb is required for pro-B cell differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Fahl SP,Crittenden RB,Allman D,Bender TP

Sun Nov 01 00:00:00 EDT 2009

NF-kappa B p50 regulates C/EBP alpha expression and inflammatory cytokine-induced neutrophil production.

Journal of immunology (Baltimore, Md. : 1950)

Wang D,Paz-Priel I,Friedman AD

Fri May 01 00:00:00 EDT 2009

Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells.

Journal of immunology (Baltimore, Md. : 1950)

Hundt M,Harada Y,De Giorgio L,Tanimura N,Zhang W,Altman A

Sat Aug 01 00:00:00 EDT 2009

Central memory CD8+ T cells induce graft-versus-host disease and mediate graft-versus-leukemia.

Journal of immunology (Baltimore, Md. : 1950)

Zheng H,Matte-Martone C,Jain D,McNiff J,Shlomchik WD

Fri May 15 00:00:00 EDT 2009

Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.

Journal of immunology (Baltimore, Md. : 1950)

Duelli A,Rönnberg E,Waern I,Ringvall M,Kolset SO,Pejler G

Tue Dec 01 00:00:00 EST 2009

Impaired mast cell activation in gene-targeted mice lacking the serum- and glucocorticoid-inducible kinase SGK1.

Journal of immunology (Baltimore, Md. : 1950)

Sobiesiak M,Shumilina E,Lam RS,Wölbing F,Matzner N,Kaesler S,Zemtsova IM,Lupescu A,Zahir N,Kuhl D,Schaller M,Biedermann T,Lang F

Thu Oct 01 00:00:00 EDT 2009

An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Kool M,van Nimwegen M,Willart MA,Muskens F,Boon L,Smit JJ,Coyle A,Clausen BE,Hoogsteden HC,Lambrecht BN,Hammad H

Wed Jul 15 00:00:00 EDT 2009

Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine.

Journal of immunology (Baltimore, Md. : 1950)

Carlens J,Wahl B,Ballmaier M,Bulfone-Paus S,Förster R,Pabst O

Sun Nov 01 00:00:00 EDT 2009

Thioredoxin-interacting protein regulates hematopoietic stem cell quiescence and mobilization under stress conditions.

Journal of immunology (Baltimore, Md. : 1950)

Jeong M,Piao ZH,Kim MS,Lee SH,Yun S,Sun HN,Yoon SR,Chung JW,Kim TD,Jeon JH,Lee J,Kim HN,Choi JY,Choi I

Sat Aug 15 00:00:00 EDT 2009

IgE influences the number and function of mature mast cells, but not progenitor recruitment in allergic pulmonary inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Mathias CB,Freyschmidt EJ,Caplan B,Jones T,Poddighe D,Xing W,Harrison KL,Gurish MF,Oettgen HC

Sun Feb 15 00:00:00 EST 2009

MicroRNA-221-222 regulate the cell cycle in mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Mayoral RJ,Pipkin ME,Pachkov M,van Nimwegen E,Rao A,Monticelli S

Thu Jan 01 00:00:00 EST 2009

Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content.

Journal of immunology (Baltimore, Md. : 1950)

Tagen M,Elorza A,Kempuraj D,Boucher W,Kepley CL,Shirihai OS,Theoharides TC

Sun Nov 15 00:00:00 EST 2009

Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation.

Experimental hematology

Mazharian A,Watson SP,Séverin S

Thu Oct 01 00:00:00 EDT 2009

cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis.

PloS one

Aicher A,Heeschen C,Feil S,Hofmann F,Mendelsohn ME,Feil R,Dimmeler S

Thu May 28 00:00:00 EDT 2009

Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis.

PloS one

Aguilar S,Scotton CJ,McNulty K,Nye E,Stamp G,Laurent G,Bonnet D,Janes SM

Tue Nov 24 00:00:00 EST 2009

A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation.

The Journal of biological chemistry

Zhao L,Dong H,Zhang CC,Kinch L,Osawa M,Iacovino M,Grishin NV,Kyba M,Huang LJ

Fri Sep 25 00:00:00 EDT 2009

Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity.

PloS one

Miletic AV,Graham DB,Sakata-Sogawa K,Hiroshima M,Hamann MJ,Cemerski S,Kloeppel T,Billadeau DD,Kanagawa O,Tokunaga M,Swat W

Wed Aug 12 00:00:00 EDT 2009

A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice.

PloS one

Johnson KJ,Griswold IJ,O'Hare T,Corbin AS,Loriaux M,Deininger MW,Druker BJ

Tue Oct 13 00:00:00 EDT 2009

FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells.

The Journal of biological chemistry

Fukushima K,Matsumura I,Ezoe S,Tokunaga M,Yasumi M,Satoh Y,Shibayama H,Tanaka H,Iwama A,Kanakura Y

Fri Mar 20 00:00:00 EDT 2009

Calpeptin increases the activity of upstream stimulatory factor and induces high level globin gene expression in erythroid cells.

The Journal of biological chemistry

Lin IJ,Zhou Z,Crusselle-Davis VJ,Moghimi B,Gandhi K,Anantharaman A,Pantic D,Huang S,Jayandharan G,Zhong L,Srivastava A,Bungert J

Fri Jul 24 00:00:00 EDT 2009

H3K79 methylation profiles define murine and human MLL-AF4 leukemias.

Cancer cell

Krivtsov AV,Feng Z,Lemieux ME,Faber J,Vempati S,Sinha AU,Xia X,Jesneck J,Bracken AP,Silverman LB,Kutok JL,Kung AL,Armstrong SA

Tue Nov 04 00:00:00 EST 2008

Interleukin-27 directly induces differentiation in hematopoietic stem cells.

Blood

Seita J,Asakawa M,Ooehara J,Takayanagi S,Morita Y,Watanabe N,Fujita K,Kudo M,Mizuguchi J,Ema H,Nakauchi H,Yoshimoto T

Fri Feb 15 00:00:00 EST 2008

Nuclear factor of activated T cells (NFAT) mediates CD154 expression in megakaryocytes.

Blood

Crist SA,Sprague DL,Ratliff TL

Tue Apr 01 00:00:00 EDT 2008

IRF8 regulates B-cell lineage specification, commitment, and differentiation.

Blood

Wang H,Lee CH,Qi C,Tailor P,Feng J,Abbasi S,Atsumi T,Morse HC

Sat Nov 15 00:00:00 EST 2008

TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice.

Blood

Zhou Y,Du W,Koretsky T,Bagby GC,Pang Q

Mon Sep 15 00:00:00 EDT 2008

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.

Proceedings of the National Academy of Sciences of the United States of America

Gan B,Sahin E,Jiang S,Sanchez-Aguilera A,Scott KL,Chin L,Williams DA,Kwiatkowski DJ,DePinho RA

Tue Dec 09 00:00:00 EST 2008

Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages.

Stem cells (Dayton, Ohio)

Schenke-Layland K,Rhodes KE,Angelis E,Butylkova Y,Heydarkhan-Hagvall S,Gekas C,Zhang R,Goldhaber JI,Mikkola HK,Plath K,MacLellan WR

Sun Jun 01 00:00:00 EDT 2008

E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.

Journal of immunology (Baltimore, Md. : 1950)

Yang Q,Kardava L,St Leger A,Martincic K,Varnum-Finney B,Bernstein ID,Milcarek C,Borghesi L

Sat Nov 01 00:00:00 EDT 2008

Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils.

Journal of immunology (Baltimore, Md. : 1950)

Watanabe M,Satoh T,Yamamoto Y,Kanai Y,Karasuyama H,Yokozeki H

Wed Oct 15 00:00:00 EDT 2008

IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma.

Journal of immunology (Baltimore, Md. : 1950)

Song C,Luo L,Lei Z,Li B,Liang Z,Liu G,Li D,Zhang G,Huang B,Feng ZH

Sat Nov 01 00:00:00 EDT 2008

DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.

The Journal of biological chemistry

Bogacheva O,Bogachev O,Menon M,Dev A,Houde E,Valoret EI,Prosser HM,Creasy CL,Pickering SJ,Grau E,Rance K,Livi GP,Karur V,Erickson-Miller CL,Wojchowski DM

Fri Dec 26 00:00:00 EST 2008

Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.

PloS one

Kalaitzidis D,Neel BG

Tue Feb 10 00:00:00 EST 2009

Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition.

BMC immunology

Kirshenbaum AS,Swindle E,Kulka M,Wu Y,Metcalfe DD

Thu Aug 07 00:00:00 EDT 2008

Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.

Blood

Yang L,Wang L,Kalfa TA,Cancelas JA,Shang X,Pushkaran S,Mo J,Williams DA,Zheng Y

Sat Dec 01 00:00:00 EST 2007

PECAM-1: a multifaceted regulator of megakaryocytopoiesis.

Blood

Wu Y,Welte T,Michaud M,Madri JA

Wed Aug 01 00:00:00 EDT 2007

TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.

The Journal of clinical investigation

Li J,Sejas DP,Zhang X,Qiu Y,Nattamai KJ,Rani R,Rathbun KR,Geiger H,Williams DA,Bagby GC,Pang Q

Thu Nov 01 00:00:00 EDT 2007

FcepsilonRI aggregation promotes survival of connective tissue-like mast cells but not mucosal-like mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Ekoff M,Strasser A,Nilsson G

Sun Apr 01 00:00:00 EDT 2007

Lyn kinase promotes erythroblast expansion and late-stage development.

Blood

Karur VG,Lowell CA,Besmer P,Agosti V,Wojchowski DM

Fri Sep 01 00:00:00 EDT 2006

Coordination of erythropoiesis by the transcription factor c-Myb.

Blood

Vegiopoulos A,García P,Emambokus N,Frampton J

Thu Jun 15 00:00:00 EDT 2006

Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.

The Journal of experimental medicine

Weller CL,Collington SJ,Brown JK,Miller HR,Al-Kashi A,Clark P,Jose PJ,Hartnell A,Williams TJ

Mon Jun 20 00:00:00 EDT 2005

Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs.

Blood

Xie X,Chan RJ,Johnson SA,Starr M,McCarthy J,Kapur R,Yoder MC

Sat Feb 15 00:00:00 EST 2003

A role for thrombopoietin in hemangioblast development.

Stem cells (Dayton, Ohio)

Perlingeiro RC,Kyba M,Bodie S,Daley GQ

Fri Feb 27 00:00:00 EST 2004

Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcepsilon receptor I cross-linking: an interspecies comparison.

Blood

Nakajima T,Inagaki N,Tanaka H,Tanaka A,Yoshikawa M,Tamari M,Hasegawa K,Matsumoto K,Tachimoto H,Ebisawa M,Tsujimoto G,Matsuda H,Nagai H,Saito H

Sun Dec 01 00:00:00 EST 2002

Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.

Stem cells (Dayton, Ohio)

Metcalf D,Mifsud S,Di Rago L

Wed Mar 12 00:00:00 EST 2003

Bioinformatics

Protein Aliases: C-kit ligand; cloud gray; DKFZp686F2250; grizzle-belly; H-SCF; Hematopoietic growth factor KL; Kit ligand; kit-ligand; M-SCF; Mast cell growth factor; MGF; SCF; Steel factor; Stem cell factor

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Gene Aliases: blz; Clo; Con; contrasted; Gb; Kitl; Kitlg; Mgf; SCF; SF; Sl; SLF

Mouse SCF Recombinant Protein, PeproTech®

Mouse SCF Protein (250-03-10UG) in Functional

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250-03-10UG

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In vitro Assay (IV)

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