Gibco

Mouse TNF-alpha Recombinant Protein, PeproTech®

Mouse TNF-alpha Protein in Functional Assay (Functional)

FIGURE: 1 / 1

Mouse TNF-alpha Protein (315-01A-20UG) in Functional

Bioassay analysis of Mouse TNF-alpha Recombinant Protein, PeproTech® (Product # 315-01A-1MG).

Product Image Gallery

Product Details

315-01A-20UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 3 publications 3 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

View 18 publications 18 publications

ChIP assay (ChIP)

View 2 publications 2 publications

Functional Assay (Functional)

Assay-dependent

View 2 publications 2 publications

In vitro Assay (IV)

View 391 publications 391 publications

Miscellaneous PubMed (Misc)

View 103 publications 103 publications

Immunostaining (IS)

View 2 publications 2 publications

Product Specifications

Species

Mouse

Published species

Bacteria, Bovine, Guinea pig, Hamster, Human, Mouse, Non-human primate, Rat

Expression System

E. coli

Amino acid sequence

MLRSSSQNSS DKPVAHVVAN HQVEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLVY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VNLLSAVKSP CPKDTPEGAE LKPWYEPIYL GGVFQLEKGD QLSAEVNLPK YLDFAESGQV YFGVIAL

Molecular weight

17.3 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 as determined by the cytolysis of murine L929 cells in the presence of actinomycin D is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Murine TNF-alpha is a soluble 156 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.

The Journal of experimental medicine

Ahmed N,Etzrodt M,Dettinger P,Kull T,Loeffler D,Hoppe PS,Chavez JS,Zhang Y,Camargo Ortega G,Hilsenbeck O,Nakajima H,Pietras EM,Schroeder T

Mon Jan 03 00:00:00 EST 2022

Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor-Induced Caspase 3/Gasdermin E-Mediated Pyroptosis.

Arthritis & rheumatology (Hoboken, N.J.)

Zhai Z,Yang F,Xu W,Han J,Luo G,Li Y,Zhuang J,Jie H,Li X,Shi X,Han X,Luo X,Song R,Chen Y,Liang J,Wu S,He Y,Sun E

Tue Mar 01 00:00:00 EST 2022

Deletion of Mettl3 at the Pro-B Stage Marginally Affects B Cell Development and Profibrogenic Activity of B Cells in Liver Fibrosis.

Journal of immunology research

Kang X,Chen S,Pan L,Liang X,Lu D,Chen H,Li Y,Liu C,Ge M,Zhang Q,Liu Q,Xu Y

315-01A was used in Sample Preparation (FC/FACS) to study whether disturbing m6A modification at later stages affects B cell development and function.

Mon Jun 27 00:00:00 EDT 2022

Hepatic RACK1 deficiency protects against fulminant hepatitis through myeloid-derived suppressor cells.

Theranostics

Liu G,Wang Q,Deng L,Huang X,Yang G,Cheng Q,Guo T,Guo L,Niu C,Yang X,Dong J,Zhang J

315-01A was used in In vitro experiments to conclude that liver-specific RACK1 deficiency protects against FH through accelerated HDAC1 degradation and the consequent CXCL1/S100A9 upregulation and MDSC accumulation.

Thu Apr 21 00:00:00 EDT 2022

Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses.

Biomedicines

Papoutsopoulou S,Morris L,Bayliff A,Mair T,England H,Stagi M,Bergey F,Alam MT,Sheibani-Tezerji R,Rosenstiel P,Müller W,Martins Dos Santos VAP,Campbell BJ

315-01A was used in In vitro experiments to investigate human RelA macrophages on murine gene transcription.

Thu Mar 24 00:00:00 EDT 2022

TNF-α/IFN-γ synergy amplifies senescence-associated inflammation and SARS-CoV-2 receptor expression via hyper-activated JAK/STAT1.

Aging cell

Kandhaya-Pillai R,Yang X,Tchkonia T,Martin GM,Kirkland JL,Oshima J

315-01A was used in In vitro experiments to find exposure of human umbilical vein endothelial cells (HUVECs) to the inflammatory cytokines, TNF-α + IFN-γ or a cocktail of TNF-α + IFN-γ + IL-6, increased expression of ACE2/DPP4, accentuated the pro-inflammatory senescence-associated secretory phenotype (SASP), and decreased cellular proliferative capacity, consistent with progression towards a cellular senescence-like state.

Wed Jun 01 00:00:00 EDT 2022

Microbial hydrogen "manufactory" for enhanced gas therapy and self-activated immunotherapy via reduced immune escape.

Journal of nanobiotechnology

Yan H,Fan M,Liu H,Xiao T,Han D,Che R,Zhang W,Zhou X,Wang J,Zhang C,Yang X,Zhang J,Li Z

315-01A was used in In vitro experiments to conclude that Hydrogen-immunotherapy significantly kills tumor cells and that our live microbial hydrogen production system provides a new strategy for cancer hydrogen treatment.

Wed Jun 15 00:00:00 EDT 2022

Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia.

Frontiers in immunology

Wallach T,Raden M,Hinkelmann L,Brehm M,Rabsch D,Weidling H,Krüger C,Kettenmann H,Backofen R,Lehnardt S

315-01A was used in In vitro experiments to determine TLR7 and TLR8 as key sensors of SARS-CoV-2-derived ssRNAs and may deepen our understanding of the mechanisms how this virus triggers, but also modulates an inflammatory response through innate immune signaling.

Tue Jan 31 00:00:00 EST 2023

Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF.

Life science alliance

Dichtl S,Sanin DE,Koss CK,Willenborg S,Petzold A,Tanzer MC,Dahl A,Kabat AM,Lindenthal L,Zeitler L,Satzinger S,Strasser A,Mann M,Roers A,Eming SA,El Kasmi KC,Pearce EJ,Murray PJ

315-01A was used in Sample Preparation to suggest that TNF's anti-M2 effects evolved to specifically modulate components of tissue and reparative M2 macrophages and TNF is therefore a context-specific modulator of M2 macrophages rather than a pan-M2 inhibitor.

Fri Apr 01 00:00:00 EDT 2022

Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT_2BR/β-arrestin2 pathway.

Journal of neuroinflammation

Fang Y,Ding X,Zhang Y,Cai L,Ge Y,Ma K,Xu R,Li S,Song M,Zhu H,Liu J,Ding J,Lu M,Hu G

315-01A was used in Cell Culture to investigate the precise interactions between fluoxetine and 5-HT2B receptor.

Sat Jan 29 00:00:00 EST 2022

Pioglitazone attenuates ischaemic stroke aggravation by blocking PPARγ reduction and inhibiting chronic inflammation in diabetic mice.

The European journal of neuroscience

Guo Y,Zuo W,Yin L,Gu T,Wang S,Fang Z,Wang B,Dong H,Hou W,Zuo Z,Deng J

315-01A was used in In vivo experiments to study whether pioglitazone use before ischaemia could reduce brain ischaemic injury.

Thu Sep 01 00:00:00 EDT 2022

The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes.

iScience

Magusto J,Beaupère C,Afonso MB,Auclair M,Delaunay JL,Soret PA,Courtois G,Aït-Slimane T,Housset C,Jéru I,Fève B,Ratziu V,Rodrigues CMP,Gautheron J

315-01A was used in Cell Culture to conclude that the absence of MLKL blocks the differentiation of white, but not beige, adipocytes highlighting the therapeutic potential of MLKL inhibition in obesity.

Fri Oct 21 00:00:00 EDT 2022

The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes.

iScience

Magusto J,Beaupère C,Afonso MB,Auclair M,Delaunay JL,Soret PA,Courtois G,Aït-Slimane T,Housset C,Jéru I,Fève B,Ratziu V,Rodrigues CMP,Gautheron J

Fri Oct 21 00:00:00 EDT 2022

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.

Cell

Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD

315-01A was used in Enzyme-linked immunosorbent assay to show that only the combination of TNF-α and IFN-γ induced inflammatory cell death characterized by inflammatory cell death, PANoptosis while multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection.

Thu Jan 07 00:00:00 EST 2021

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.

Cell

Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD

Thu Jan 07 00:00:00 EST 2021

The Lysosomal Rag-Ragulator Complex Licenses RIPK1 and Caspase-8-mediated Pyroptosis by Yersinia.

Science (New York, N.Y.)

Zheng Z,Deng W,Bai Y,Miao R,Mei S,Zhang Z,Pan Y,Wang Y,Min R,Deng F,Wu Z,Li W,Chen P,Ma T,Lou X,Lieberman J,Liu X

315-01A was used in Cell Culture to use a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen to uncover mediators of caspase-8-dependent pyroptosis.

Fri Jun 25 00:00:00 EDT 2021

The Lysosomal Rag-Ragulator Complex Licenses RIPK1 and Caspase-8-mediated Pyroptosis by Yersinia.

Science (New York, N.Y.)

Zheng Z,Deng W,Bai Y,Miao R,Mei S,Zhang Z,Pan Y,Wang Y,Min R,Deng F,Wu Z,Li W,Chen P,Ma T,Lou X,Lieberman J,Liu X

315-01A was used in Cell Culture to use a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen to uncover mediators of caspase-8-dependent pyroptosis.

Fri Jun 25 00:00:00 EDT 2021

Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer.

Immunity

Tello-Lafoz M,Srpan K,Sanchez EE,Hu J,Remsik J,Romin Y,Calò A,Hoen D,Bhanot U,Morris L,Boire A,Hsu KC,Massagué J,Huse M,Er EE

Tue May 11 00:00:00 EDT 2021

SPLUNC1: a novel marker of cystic fibrosis exacerbations.

The European respiratory journal

Khanal S,Webster M,Niu N,Zielonka J,Nunez M,Chupp G,Slade MD,Cohn L,Sauler M,Gomez JL,Tarran R,Sharma L,Dela Cruz CS,Egan M,Laguna T,Britto CJ

315-01A was used in Cell Culture to show that in acute CF care, low SPLUNC1 levels could support a decision to increase airway clearance or to initiate pharmacological interventions.

Mon Nov 01 00:00:00 EDT 2021

Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells.

Cellular & molecular immunology

Zhang J,Huang J,Gu Y,Xue M,Qian F,Wang B,Yang W,Yu H,Wang Q,Guo X,Ding X,Wang J,Jin M,Zhang Y

Tue Jun 01 00:00:00 EDT 2021

The integrated stress response mediates necrosis in murine Mycobacterium tuberculosis granulomas.

The Journal of clinical investigation

Bhattacharya B,Xiao S,Chatterjee S,Urbanowski M,Ordonez A,Ihms EA,Agrahari G,Lun S,Berland R,Pichugin A,Gao Y,Connor J,Ivanov AR,Yan BS,Kobzik L,Koo BB,Jain S,Bishai W,Kramnik I

Mon Feb 01 00:00:00 EST 2021

Cell-type-specific binocular vision guides predation in mice.

Neuron

Johnson KP,Fitzpatrick MJ,Zhao L,Wang B,McCracken S,Williams PR,Kerschensteiner D

Wed May 05 00:00:00 EDT 2021

Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis.

The Journal of experimental medicine

Marki A,Buscher K,Lorenzini C,Meyer M,Saigusa R,Fan Z,Yeh YT,Hartmann N,Dan JM,Kiosses WB,Golden GJ,Ganesan R,Winkels H,Orecchioni M,McArdle S,Mikulski Z,Altman Y,Bui J,Kronenberg M,Chien S,Esko JD,Nizet V,Smalley D,Roth J,Ley K

Mon Mar 01 00:00:00 EST 2021

Mechanical force-driven TNFα endocytosis governs stem cell homeostasis.

Bone research

Yu W,Chen C,Kou X,Sui B,Yu T,Liu D,Wang R,Wang J,Shi S

Fri Jan 01 00:00:00 EST 2021

RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling.

Proceedings of the National Academy of Sciences of the United States of America

Chen KW,Demarco B,Ramos S,Heilig R,Goris M,Grayczyk JP,Assenmacher CA,Radaelli E,Joannas LD,Henao-Mejia J,Tacchini-Cottier F,Brodsky IE,Broz P

Tue Jul 13 00:00:00 EDT 2021

Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways.

Proceedings of the National Academy of Sciences of the United States of America

Prado J,Westerink RHS,Popov-Celeketic J,Steen-Louws C,Pandit A,Versteeg S,van de Worp W,Kanters DHAJ,Reedquist KA,Koenderman L,Hack CE,Eijkelkamp N

Tue Mar 16 00:00:00 EDT 2021

OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation.

Cell death and differentiation

Koschel J,Nishanth G,Just S,Harit K,Kröger A,Deckert M,Naumann M,Schlüter D

Thu Jul 01 00:00:00 EDT 2021

Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers.

Gut microbes

Fasciano AC,Dasanayake GS,Estes MK,Zachos NC,Breault DT,Isberg RR,Tan S,Mecsas J

315-01A was used in Cell Culture to indicate that early infectious stage Yersinia pseudotuberculosis (Yptb) more effectively penetrates M cells while the host may defend against M cell penetration of host-adapted Yptb.

Tue Mar 01 00:00:00 EST 2022

Promyelocytic leukemia protein targets MK2 to promote cytotoxicity.

EMBO reports

Chen IT,Chen HC,Lo YH,Lai PY,Hsieh FY,Wu YH,Shih HM,Lai MZ

Mon Dec 06 00:00:00 EST 2021

Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53.

Oncogene

Lindzen M,Ghosh S,Noronha A,Drago D,Nataraj NB,Leitner O,Carvalho S,Zmora E,Sapoznik S,Shany KB,Levanon K,Aderka D,Ramírez BS,Dahlhoff M,McNeish I,Yarden Y

Sat May 01 00:00:00 EDT 2021

The different biological effects of TMPyP4 and cisplatin in the inflammatory microenvironment of osteosarcoma are attributed to G-quadruplex.

Cell proliferation

Chen J,Jin X,Mei Y,Shen Z,Zhu J,Shi H,Wang M,Zheng X,Liang G

Wed Sep 01 00:00:00 EDT 2021

Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice.

Mucosal immunology

Fattinger SA,Geiser P,Samperio Ventayol P,Di Martino ML,Furter M,Felmy B,Bakkeren E,Hausmann A,Barthel-Scherrer M,Gül E,Hardt WD,Sellin ME

Sat May 01 00:00:00 EDT 2021

Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Canedo T,Portugal CC,Socodato R,Almeida TO,Terceiro AF,Bravo J,Silva AI,Magalhães JD,Guerra-Gomes S,Oliveira JF,Sousa N,Magalhães A,Relvas JB,Summavielle T

Wed Dec 01 00:00:00 EST 2021

Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Canedo T,Portugal CC,Socodato R,Almeida TO,Terceiro AF,Bravo J,Silva AI,Magalhães JD,Guerra-Gomes S,Oliveira JF,Sousa N,Magalhães A,Relvas JB,Summavielle T

Wed Dec 01 00:00:00 EST 2021

An asymmetric junctional mechanoresponse coordinates mitotic rounding with epithelial integrity.

The Journal of cell biology

Monster JL,Donker L,Vliem MJ,Win Z,Matthews HK,Cheah JS,Yamada S,de Rooij J,Baum B,Gloerich M

Mon May 03 00:00:00 EDT 2021

Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes.

Glia

Muraleedharan A,Rotem-Dai N,Strominger I,Anto NP,Isakov N,Monsonego A,Livneh E

Mon Mar 01 00:00:00 EST 2021

Mesenchymal stromal cells expressing a dominant-negative high mobility group A1 transgene exhibit improved function during sepsis.

Journal of leukocyte biology

Kwon MY,Ghanta S,Ng J,Castano AP,Han J,Ith B,Lederer JA,El-Chemaly S,Chung SW,Liu X,Perrella MA

Fri Oct 01 00:00:00 EDT 2021

Blockade of PD-1/PD-L1 Pathway Enhances the Antigen-Presenting Capacity of Fibrocytes.

Journal of immunology (Baltimore, Md. : 1950)

Afroj T,Mitsuhashi A,Ogino H,Saijo A,Otsuka K,Yoneda H,Tobiume M,Nguyen NT,Goto H,Koyama K,Sugimoto M,Kondoh O,Nokihara H,Nishioka Y

315-01A was used in Cell Culture to study the function of fibrocytes in the tumor microenvironment and in tumor immunity induced by immune checkpoint inhibitor therapy to suggest that fibrocytes infiltrating tumor sites may play a role in the antitumor immunity mediated by CD8+ T cells when the activity is further enhanced by PD-L1/PD-1 blockade.

Mon Mar 15 00:00:00 EDT 2021

Characterization of a TNFR2-Selective Agonistic TNF-α Mutant and Its Derivatives as an Optimal Regulatory T Cell Expander.

Journal of immunology (Baltimore, Md. : 1950)

Inoue M,Yamashita K,Tsuji Y,Miki M,Amano S,Okumura T,Kuge K,Tone T,Enomoto S,Yoshimine C,Morita Y,Ando D,Kamada H,Mikami N,Tsutsumi Y,Tsunoda SI

Thu Apr 15 00:00:00 EDT 2021

Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2'3'-Cyclic GMP-AMP and Cisplatin under Steady State and Inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Chen X,Wang L,Cao L,Li T,Li Z,Sun Y,Ding J,Zhou C,Xie Y,Yue N,Nan J,Jia XM,Peng C,Li H,Yang J,Xiao H

Sat May 01 00:00:00 EDT 2021

Scaffold compound L971 exhibits anti-inflammatory activities through inhibition of JAK/STAT and NFκB signalling pathways.

Journal of cellular and molecular medicine

Li M,Yan Y,Zhang X,Zhang Y,Xu X,Zhang L,Lu L,Wang J,Zhang Y,Song Q,Zhao C

Thu May 20 00:00:00 EDT 2021

Effect of Lipopolysaccharide and TNFα on Neuronal Ascorbic Acid Uptake.

Mediators of inflammation

Subramanian VS,Teafatiller T,Agrawal A,Kitazawa M,Marchant JS

Thu Mar 31 00:00:00 EDT 2022

Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome.

Cell reports

Qin Q,Shou J,Li M,Gu M,Meng Z,Xu P,Meng H,Wang X

Tue May 25 00:00:00 EDT 2021

Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF.

Cell death & disease

Buffolo F,Petrosino V,Albini M,Moschetta M,Carlini F,Floss T,Kerlero de Rosbo N,Cesca F,Rocchi A,Uccelli A,Benfenati F

Mon Feb 15 00:00:00 EST 2021

TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG.

Theranostics

Xu C,Wu J,Wu Y,Ren Z,Yao Y,Chen G,Fang EF,Noh JH,Liu YU,Wei L,Chen X,Sima J

315-01A was used in In vitro experiments to identify a finely controlled regulation of neuronal necroptosis in AD by coordinated TNF-α signaling, RIPK1/3 activity and autophagy machinery.

Mon Feb 07 00:00:00 EST 2022

Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis.

iScience

Chatterjee S,Yabaji SM,Rukhlenko OS,Bhattacharya B,Waligurski E,Vallavoju N,Ray S,Kholodenko BN,Brown LE,Beeler AB,Ivanov AR,Kobzik L,Porco JA,Kramnik I

Fri Aug 20 00:00:00 EDT 2021

CD39⁺PD-1⁺CD8⁺ T cells mediate metastatic dormancy in breast cancer.

Nature communications

Tallón de Lara P,Castañón H,Vermeer M,Núñez N,Silina K,Sobottka B,Urdinez J,Cecconi V,Yagita H,Movahedian Attar F,Hiltbrunner S,Glarner I,Moch H,Tugues S,Becher B,van den Broek M

Wed Feb 03 00:00:00 EST 2021

Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3.

Cell death & disease

Xia Y,Wang P,Yan N,Gonzalez FJ,Yan T

Thu Feb 11 00:00:00 EST 2021

Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis.

Cell reports

Nanou A,Bourbouli M,Vetrano S,Schaeper U,Ley S,Kollias G

Tue May 25 00:00:00 EDT 2021

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis.

Nature communications

Samuel M,Fonseka P,Sanwlani R,Gangoda L,Chee SH,Keerthikumar S,Spurling A,Chitti SV,Zanker D,Ang CS,Atukorala I,Kang T,Shahi S,Marzan AL,Nedeva C,Vennin C,Lucas MC,Cheng L,Herrmann D,Pathan M,Chisanga D,Warren SC,Zhao K,Abraham N,Anand S,Boukouris S,Adda CG,Jiang L,Shekhar TM,Baschuk N,Hawkins CJ,Johnston AJ,Orian JM,Hoogenraad NJ,Poon IK,Hill AF,Jois M,Timpson P,Parker BS,Mathivanan S

Thu Jun 24 00:00:00 EDT 2021

Multiple Autonomous Cell Death Suppression Strategies Ensure Cytomegalovirus Fitness.

Viruses

Mandal P,Nagrani LN,Hernandez L,McCormick AL,Dillon CP,Koehler HS,Roback L,Alnemri ES,Green DR,Mocarski ES

315-01A was used in Cell Culture to study three ell autonomous suppression mechanisms on which murine cytomegalovirus relies: (i) M38.5-encoded viral mitochondrial inhibitor of apoptosis (vMIA), a BAX suppressor that functions in concert with M41.1-encoded viral inhibitor of BAK oligomerization (vIBO), (ii) M36-encoded viral inhibitor of caspase-8 activation (vICA), and (iii) M45-encoded viral inhibitor of RIP/RHIM activation (vIRA).

Fri Aug 27 00:00:00 EDT 2021

Endothelial STING controls T cell transmigration in an IFNI-dependent manner.

JCI insight

Anastasiou M,Newton GA,Kaur K,Carrillo-Salinas FJ,Smolgovsky SA,Bayer AL,Ilyukha V,Sharma S,Poltorak A,Luscinskas FW,Alcaide P

315-01A was used in In vitro experiments to investigate IFN signalling effect on T cell transdoepithelial infiltration.

Mon Aug 09 00:00:00 EDT 2021

Castration-mediated IL-8 promotes myeloid infiltration and prostate cancer progression.

Nature cancer

Lopez-Bujanda ZA,Haffner MC,Chaimowitz MG,Chowdhury N,Venturini NJ,Patel RA,Obradovic A,Hansen CS,Jacków J,Maynard JP,Sfanos KS,Abate-Shen C,Bieberich CJ,Hurley PJ,Selby MJ,Korman AJ,Christiano AM,De Marzo AM,Drake CG

315-01A was used in Chromatin immunoprecipitation to investigate prostate cancer response to immune checkpoint blockade.

Sun Aug 01 00:00:00 EDT 2021

Castration-mediated IL-8 promotes myeloid infiltration and prostate cancer progression.

Nature cancer

315-01A was used in Chromatin immunoprecipitation to investigate prostate cancer response to immune checkpoint blockade.

Sun Aug 01 00:00:00 EDT 2021

Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity.

iScience

Yoshida N,Yamashita T,Osone T,Hosooka T,Shinohara M,Kitahama S,Sasaki K,Sasaki D,Yoneshiro T,Suzuki T,Emoto T,Saito Y,Ozawa G,Hirota Y,Kitaura Y,Shimomura Y,Okamatsu-Ogura Y,Saito M,Kondo A,Kajimura S,Inagaki T,Ogawa W,Yamada T,Hirata KI

Fri Nov 19 00:00:00 EST 2021

Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells.

eLife

Kiritsy MC,McCann K,Mott D,Holland SM,Behar SM,Sassetti CM,Olive AJ

315-01A was used in In vitro experiments to study the metabolic dependencies of critical signals such as interferon gamma (IFNγ) for allowing antigen-presenting cells (APCs) to convey a wide array of functionally distinct signals to T cells. To demonstrate that IFNγ response requires mitochondrial respiration, and APCs are unable to activate T cells upon genetic or chemical inhibition of complex I.

Tue Nov 02 00:00:00 EDT 2021

TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.

Nature communications

Yabe R,Chung SH,Murayama MA,Kubo S,Shimizu K,Akahori Y,Maruhashi T,Seno A,Kaifu T,Saijo S,Iwakura Y

Mon Jan 04 00:00:00 EST 2021

Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.

Nature communications

Schumacher MA,Hsieh JJ,Liu CY,Appel KL,Waddell A,Almohazey D,Katada K,Bernard JK,Bucar EB,Gadeock S,Maselli KM,Washington MK,Grikscheit TC,Warburton D,Rosen MJ,Frey MR

Fri Feb 05 00:00:00 EST 2021

Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy.

Nature communications

Srivastava SP,Zhou H,Setia O,Liu B,Kanasaki K,Koya D,Dardik A,Fernandez-Hernando C,Goodwin J

Thu Apr 22 00:00:00 EDT 2021

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.

Cell reports

Karki R,Sundaram B,Sharma BR,Lee S,Malireddi RKS,Nguyen LN,Christgen S,Zheng M,Wang Y,Samir P,Neale G,Vogel P,Kanneganti TD

Tue Oct 19 00:00:00 EDT 2021

Inhibition of LTβR signalling activates WNT-induced regeneration in lung.

Nature

Conlon TM,John-Schuster G,Heide D,Pfister D,Lehmann M,Hu Y,Ertüz Z,Lopez MA,Ansari M,Strunz M,Mayr C,Angelidis I,Ciminieri C,Costa R,Kohlhepp MS,Guillot A,Günes G,Jeridi A,Funk MC,Beroshvili G,Prokosch S,Hetzer J,Verleden SE,Alsafadi H,Lindner M,Burgstaller G,Becker L,Irmler M,Dudek M,Janzen J,Goffin E,Gosens R,Knolle P,Pirotte B,Stoeger T,Beckers J,Wagner D,Singh I,Theis FJ,de Angelis MH,O'Connor T,Tacke F,Boutros M,Dejardin E,Eickelberg O,Schiller HB,Königshoff M,Heikenwalder M,Yildirim AÖ

315-01A was used in In vitro experiments to demonstrate differential expression, signalling, and target gene expression of the lymphotoxin β-receptor in response to cigarette smoke in humans and mice.

Tue Dec 01 00:00:00 EST 2020

Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma.

Immunity

Effern M,Glodde N,Braun M,Liebing J,Boll HN,Yong M,Bawden E,Hinze D,van den Boorn-Konijnenberg D,Daoud M,Aymans P,Landsberg J,Smyth MJ,Flatz L,Tüting T,Bald T,Gebhardt T,Hölzel M

Tue Sep 15 00:00:00 EDT 2020

Aging-induced IL27Ra signaling impairs hematopoietic stem cells.

Blood

He H,Xu P,Zhang X,Liao M,Dong Q,Cong T,Tang B,Yang X,Ye M,Chang Y,Liu W,Wang X,Ju Z,Wang J

Thu Jul 09 00:00:00 EDT 2020

JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.

Blood

Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE

Thu Aug 06 00:00:00 EDT 2020

Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.

The Journal of clinical investigation

Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F

Mon Mar 02 00:00:00 EST 2020

Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.

The Journal of clinical investigation

Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F

Mon Mar 02 00:00:00 EST 2020

IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury.

The Journal of clinical investigation

Xiong S,Hong Z,Huang LS,Tsukasaki Y,Nepal S,Di A,Zhong M,Wu W,Ye Z,Gao X,Rao GN,Mehta D,Rehman J,Malik AB

Wed Jul 01 00:00:00 EDT 2020

Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.

The Journal of clinical investigation

Hyun J,Sun Z,Ahmadi AR,Bangru S,Chembazhi UV,Du K,Chen T,Tsukamoto H,Rusyn I,Kalsotra A,Diehl AM

Wed Apr 01 00:00:00 EDT 2020

The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses.

The Journal of experimental medicine

Arnold IC,Artola-Boran M,Gurtner A,Bertram K,Bauer M,Frangez Z,Becher B,Kopf M,Yousefi S,Simon HU,Tzankov A,Müller A

Mon Dec 07 00:00:00 EST 2020

Additive Therapeutic Effects of Mesenchymal Stem Cells and IL-37 for Systemic Lupus Erythematosus.

Journal of the American Society of Nephrology : JASN

Xu J,Chen J,Li W,Lian W,Huang J,Lai B,Li L,Huang Z

315-01A was used in In vitro experiments to investigate the effect of overexpressing IL-37 on the therapeutic effects of mesenchymal stem cells for Systemic Lupus Erythematosus treatment.

Wed Jan 01 00:00:00 EST 2020

A new perspective of triptolide-associated hepatotoxicity: the relevance of NF- B and NF- B-mediated cellular FLICE-inhibitory protein.

Acta pharmaceutica Sinica. B

Yuan Z,Yuan Z,Hasnat M,Zhang H,Liang P,Sun L,Jiang Z,Zhang L

315-01A was used in In vivo experiments to study the role of lipopolysaccharide (LPS) in triptolide/LPS-induced hepatotoxicity and the mechanism by which triptolide induces liver hypersensitivity upon LPS stimulation.

Fri May 01 00:00:00 EDT 2020

Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway.

The EMBO journal

Ipseiz N,Pickering RJ,Rosas M,Tyrrell VJ,Davies LC,Orr SJ,Czubala MA,Fathalla D,Robertson AA,Bryant CE,O'Donnell V,Taylor PR

Wed Jul 15 00:00:00 EDT 2020

Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop.

The EMBO journal

Draberova H,Janusova S,Knizkova D,Semberova T,Pribikova M,Ujevic A,Harant K,Knapkova S,Hrdinka M,Fanfani V,Stracquadanio G,Drobek A,Ruppova K,Stepanek O,Draber P

Tue Sep 01 00:00:00 EDT 2020

Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation.

Proceedings of the National Academy of Sciences of the United States of America

Mikami N,Kawakami R,Chen KY,Sugimoto A,Ohkura N,Sakaguchi S

Tue Jun 02 00:00:00 EDT 2020

Innate immune receptor NOD2 mediates LGR5⁺ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation.

Proceedings of the National Academy of Sciences of the United States of America

Levy A,Stedman A,Deutsch E,Donnadieu F,Virgin HW,Sansonetti PJ,Nigro G

Tue Jan 28 00:00:00 EST 2020

Imaging of translocator protein upregulation is selective for pro-inflammatory polarized astrocytes and microglia.

Glia

Pannell M,Economopoulos V,Wilson TC,Kersemans V,Isenegger PG,Larkin JR,Smart S,Gilchrist S,Gouverneur V,Sibson NR

Sat Feb 01 00:00:00 EST 2020

Imaging of translocator protein upregulation is selective for pro-inflammatory polarized astrocytes and microglia.

Glia

Pannell M,Economopoulos V,Wilson TC,Kersemans V,Isenegger PG,Larkin JR,Smart S,Gilchrist S,Gouverneur V,Sibson NR

Sat Feb 01 00:00:00 EST 2020

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease.

Stem cells translational medicine

Losurdo M,Pedrazzoli M,D'Agostino C,Elia CA,Massenzio F,Lonati E,Mauri M,Rizzi L,Molteni L,Bresciani E,Dander E,D'Amico G,Bulbarelli A,Torsello A,Matteoli M,Buffelli M,Coco S

Tue Sep 01 00:00:00 EDT 2020

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease.

Stem cells translational medicine

Losurdo M,Pedrazzoli M,D'Agostino C,Elia CA,Massenzio F,Lonati E,Mauri M,Rizzi L,Molteni L,Bresciani E,Dander E,D'Amico G,Bulbarelli A,Torsello A,Matteoli M,Buffelli M,Coco S

Tue Sep 01 00:00:00 EDT 2020

The aryl hydrocarbon receptor promotes inflammation-induced dedifferentiation and systemic metastatic spread of melanoma cells.

International journal of cancer

Mengoni M,Braun AD,Gaffal E,Tüting T

Sun Nov 15 00:00:00 EST 2020

Selective Interferon Responses of Intestinal Epithelial Cells Minimize Tumor Necrosis Factor Alpha Cytotoxicity.

Journal of virology

Van Winkle JA,Constant DA,Li L,Nice TJ

315-01A was used in Tissue/organ culture to study that type III IFN treatment elicits robust and uniform ISG expression in neonatal mouse IECs and inhibits the replication of IEC-tropic rotavirus.

Wed Oct 14 00:00:00 EDT 2020

The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Hughes KR,Schofield Z,Dalby MJ,Caim S,Chalklen L,Bernuzzi F,Alcon-Giner C,Le Gall G,Watson AJM,Hall LJ

Fri May 01 00:00:00 EDT 2020

Regulatory network mediated by RBP-J/NFATc1-miR182 controls inflammatory bone resorption.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Inoue K,Hu X,Zhao B

Sat Feb 01 00:00:00 EST 2020

Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Kralova J,Drobek A,Prochazka J,Spoutil F,Fabisik M,Glatzova D,Borna S,Pokorna J,Skopcova T,Angelisova P,Gregor M,Kovarik P,Sedlacek R,Brdicka T

Sun Mar 15 00:00:00 EDT 2020

Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ.

Journal of immunology (Baltimore, Md. : 1950)

Kidder K,Bian Z,Shi L,Liu Y

Sun Nov 15 00:00:00 EST 2020

An IL-17F.S65L Knock-In Mouse Reveals Similarities and Differences in IL-17F Function in Oral Candidiasis: A New Tool to Understand IL-17F.

Journal of immunology (Baltimore, Md. : 1950)

Zhou C,Monin L,Gordon R,Aggor FEY,Bechara R,Edwards TN,Kaplan DH,Gingras S,Gaffen SL

Sat Aug 01 00:00:00 EDT 2020

Small GTPase ARF6 Is a Coincidence-Detection Code for RPH3A Polarization in Neutrophil Polarization.

Journal of immunology (Baltimore, Md. : 1950)

Ren C,Yuan Q,Jian X,Randazzo PA,Tang W,Wu D

Sat Feb 15 00:00:00 EST 2020

Self-Antigens Displayed on Liposomal Nanoparticles above a Threshold of Epitope Density Elicit Class-Switched Autoreactive Antibodies Independent of T Cell Help.

Journal of immunology (Baltimore, Md. : 1950)

Chen Z,Wholey WY,Hassani Najafabadi A,Moon JJ,Grigorova I,Chackerian B,Cheng W

Wed Jan 15 00:00:00 EST 2020

Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism.

American journal of physiology. Cell physiology

Liu F,Wang X,Geng H,Bu HF,Wang P,De Plaen IG,Yang H,Qian J,Tan XD

Wed Apr 01 00:00:00 EDT 2020

Molecular dissection of TNFR-TNFα bidirectional signaling reveals both cooperative and antagonistic interactions with p75 neurotrophic factor receptor in axon patterning.

Molecular and cellular neurosciences

Kuhn KD,Edamura K,Bhatia N,Cheng I,Clark SA,Haynes CV,Heffner DL,Kabir F,Velasquez J,Spano AJ,Deppmann CD,Keeler AB

315-01A was used in Cell Culture to demonstrate several levels of synergistic and antagonistic interactions using very few signaling pathways and that the balance of these synergizing and opposing signals act to ensure proper axon growth and patterning.

Sun Mar 01 00:00:00 EST 2020

ATP reduces mitochondrial MECR protein in liver of diet-induced obese mice in mechanism of insulin resistance.

Bioscience reports

Qian S,Ma L,Peng S,Xu Y,Wu K,Shen S,Zhang X,Sun Y,Ye J

315-01A was used in Cell Culture to investigate Mitochondrial 2-enoyl-acyl-carrier protein reductase (MECR) activity in diet-induced obese (DIO) mice.

Fri Jun 26 00:00:00 EDT 2020

Structural optimization of a TNFR1-selective antagonistic TNFα mutant to create new-modality TNF-regulating biologics.

The Journal of biological chemistry

Inoue M,Tsuji Y,Yoshimine C,Enomoto S,Morita Y,Osaki N,Kunishige M,Miki M,Amano S,Yamashita K,Kamada H,Tsutsumi Y,Tsunoda SI

Fri Jul 10 00:00:00 EDT 2020

Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation.

Cell death & disease

Wu YH,Chou TF,Young L,Hsieh FY,Pan HY,Mo ST,Brown SB,Chen RH,Kimchi A,Lai MZ

Mon May 04 00:00:00 EDT 2020

Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation.

Cell death & disease

Wu YH,Chou TF,Young L,Hsieh FY,Pan HY,Mo ST,Brown SB,Chen RH,Kimchi A,Lai MZ

Mon May 04 00:00:00 EDT 2020

Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis.

Scientific reports

Waidmann O,Pleli T,Weigert A,Imelmann E,Kakoschky B,Schmithals C,Döring C,Frank M,Longerich T,Köberle V,Hansmann ML,Brüne B,Zeuzem S,Piiper A,Dikic I

Thu Oct 01 00:00:00 EDT 2020

The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG.

Cell reports

Landgraf K,Klöting N,Gericke M,Maixner N,Guiu-Jurado E,Scholz M,Witte AV,Beyer F,Schwartze JT,Lacher M,Villringer A,Kovacs P,Rudich A,Blüher M,Kiess W,Körner A

315-01A was used in In vitro experiments to investigate TMEM18 in childhood obesity.

Tue Oct 20 00:00:00 EDT 2020

Inflammasome Assays In Vitro and in Mouse Models.

Current protocols in immunology

Guo H,Ting JP

315-01A was used in In vitro experiments to present assays that allow induction and measurement of activation of different inflammasomes in mouse macrophages, human peripheral blood mononuclear cell (PBMC) cultures, and mouse peritonitis and endotoxic shock models.

Tue Dec 01 00:00:00 EST 2020

CD49a Regulates Cutaneous Resident Memory CD8⁺ T Cell Persistence and Response.

Cell reports

Bromley SK,Akbaba H,Mani V,Mora-Buch R,Chasse AY,Sama A,Luster AD

315-01A was used in In vitro experiments to study the requirement for CD49a in the formation, localization, persistence, and function of cutaneous CD8+ tissue-resident memory T cells.

Tue Sep 01 00:00:00 EDT 2020

The secondary bile acids, ursodeoxycholic acid and lithocholic acid, protect against intestinal inflammation by inhibition of epithelial apoptosis.

Physiological reports

Lajczak-McGinley NK,Porru E,Fallon CM,Smyth J,Curley C,McCarron PA,Tambuwala MM,Roda A,Keely SJ

Mon Jun 01 00:00:00 EDT 2020

MCD diet-induced steatohepatitis generates a diurnal rhythm of associated biomarkers and worsens liver injury in Klf10 deficient mice.

Scientific reports

Leclère PS,Rousseau D,Patouraux S,Guérin S,Bonnafous S,Gréchez-Cassiau A,Ruberto AA,Luci C,Subramaniam M,Tran A,Delaunay F,Gual P,Teboul M

315-01A was used in Cell Culture to identify KLF10 as a component of this transcriptional reprogramming and a novel hepato-protective factor.

Wed Jul 22 00:00:00 EDT 2020

Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes.

bioRxiv : the preprint server for biology

Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD

315-01A was used in In vitro experiments to reveal that blocking the COVID-19 cytokine-mediated inflammatory cell death signaling pathway identified in this study may benefit patients with COVID-19 or other cytokine storm-driven syndromes by limiting inflammation and tissue damage.

Fri Nov 13 00:00:00 EST 2020

YAP and TAZ protect against white adipocyte cell death during obesity.

Nature communications

Wang L,Wang S,Shi Y,Li R,Günther S,Ong YT,Potente M,Yuan Z,Liu E,Offermanns S

Wed Oct 28 00:00:00 EDT 2020

Effective Nephroprotection Against Acute Kidney Injury with a Star-Shaped Polyglutamate-Curcuminoid Conjugate.

Scientific reports

Córdoba-David G,Duro-Castano A,Castelo-Branco RC,González-Guerrero C,Cannata P,Sanz AB,Vicent MJ,Ortiz A,Ramos AM

Thu Feb 06 00:00:00 EST 2020

Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis.

eLife

Deng Z,Ng C,Inoue K,Chen Z,Xia Y,Hu X,Greenblatt M,Pernis A,Zhao B

315-01A was used in Cell Culture to investigate Def6 regulation in osteoblastic bone remodelling.

Tue Dec 29 00:00:00 EST 2020

Conjugation of TLR7 Agonist Combined with Demethylation Treatment Improves Whole-Cell Tumor Vaccine Potency in Acute Myeloid Leukemia.

International journal of medical sciences

Zhong G,Jin G,Zeng W,Yu C,Li Y,Zhou J,Zhang L,Yu L

315-01A was used in Cell Culture to study the poor efficacy of immunotherapies based on the 'patients' immune response to tumor cells which lead to minimal residual disease (MRD) after treatment.

Tue Jul 06 00:00:00 EDT 2021

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.

Nature communications

Mayr L,Grabherr F,Schwärzler J,Reitmeier I,Sommer F,Gehmacher T,Niederreiter L,He GW,Ruder B,Kunz KTR,Tymoszuk P,Hilbe R,Haschka D,Feistritzer C,Gerner RR,Enrich B,Przysiecki N,Seifert M,Keller MA,Oberhuber G,Sprung S,Ran Q,Koch R,Effenberger M,Tancevski I,Zoller H,Moschen AR,Weiss G,Becker C,Rosenstiel P,Kaser A,Tilg H,Adolph TE

Tue Apr 14 00:00:00 EDT 2020

In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations.

Cell death & disease

Miles MA,Hawkins CJ

Thu Aug 13 00:00:00 EDT 2020

Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor.

Scientific reports

Rambousek L,Gschwind T,Lafourcade C,Paterna JC,Dib L,Fritschy JM,Fontana A

Fri Feb 28 00:00:00 EST 2020

Progranulin modulates cartilage-specific gene expression via sirtuin 1-mediated deacetylation of the transcription factors SOX9 and P65.

The Journal of biological chemistry

Feng D,Kang X,Wang R,Chen H,Zhang K,Feng W,Li H,Zhu Y,Wu S

Fri Sep 25 00:00:00 EDT 2020

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses.

Cell

Nagai M,Noguchi R,Takahashi D,Morikawa T,Koshida K,Komiyama S,Ishihara N,Yamada T,Kawamura YI,Muroi K,Hattori K,Kobayashi N,Fujimura Y,Hirota M,Matsumoto R,Aoki R,Tamura-Nakano M,Sugiyama M,Katakai T,Sato S,Takubo K,Dohi T,Hase K

Thu Aug 22 00:00:00 EDT 2019

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.

Cell

Mogilenko DA,Haas JT,L'homme L,Fleury S,Quemener S,Levavasseur M,Becquart C,Wartelle J,Bogomolova A,Pineau L,Molendi-Coste O,Lancel S,Dehondt H,Gheeraert C,Melchior A,Dewas C,Nikitin A,Pic S,Rabhi N,Annicotte JS,Oyadomari S,Velasco-Hernandez T,Cammenga J,Foretz M,Viollet B,Vukovic M,Villacreces A,Kranc K,Carmeliet P,Marot G,Boulter A,Tavernier S,Berod L,Longhi MP,Paget C,Janssens S,Staumont-Sallé D,Aksoy E,Staels B,Dombrowicz D

Thu May 16 00:00:00 EDT 2019

The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.

Immunity

Kusnadi A,Park SH,Yuan R,Pannellini T,Giannopoulou E,Oliver D,Lu T,Park-Min KH,Ivashkiv LB

Tue Aug 20 00:00:00 EDT 2019

Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB.

Immunity

Webb LV,Barbarulo A,Huysentruyt J,Vanden Berghe T,Takahashi N,Ley S,Vandenabeele P,Seddon B

Tue Feb 19 00:00:00 EST 2019

Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.

Immunity

Dahlgren MW,Jones SW,Cautivo KM,Dubinin A,Ortiz-Carpena JF,Farhat S,Yu KS,Lee K,Wang C,Molofsky AV,Tward AD,Krummel MF,Peng T,Molofsky AB

Tue Mar 19 00:00:00 EDT 2019

Inflammatory signals directly instruct PU.1 in HSCs via TNF.

Blood

Etzrodt M,Ahmed N,Hoppe PS,Loeffler D,Skylaki S,Hilsenbeck O,Kokkaliaris KD,Kaltenbach HM,Stelling J,Nerlov C,Schroeder T

Thu Feb 21 00:00:00 EST 2019

A role for macrophages in hematopoiesis in the embryonic head.

Blood

Li Z,Mariani SA,Rodriguez-Seoane C,He W,Ning X,Liu B,Vink CS,Dzierzak E

Thu Nov 28 00:00:00 EST 2019

Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense.

Cell stem cell

Chen M,Reed RR,Lane AP

315-01A was used in Enzyme-linked immunosorbent assay to establish a mechanism whereby chronic rhinosinusitis inflammation causes a functional switch of neuroepithelial stem cells from regeneration to immune defense.

Thu Oct 03 00:00:00 EDT 2019

Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense.

Cell stem cell

Chen M,Reed RR,Lane AP

Thu Oct 03 00:00:00 EDT 2019

Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense.

Cell stem cell

Chen M,Reed RR,Lane AP

Thu Oct 03 00:00:00 EDT 2019

TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy.

The Journal of clinical investigation

Sharma D,Malik A,Guy C,Vogel P,Kanneganti TD

Wed Jan 02 00:00:00 EST 2019

Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis.

The Journal of clinical investigation

Miyabe C,Miyabe Y,Bricio-Moreno L,Lian J,Rahimi RA,Miura NN,Ohno N,Iwakura Y,Kawakami T,Luster AD

Thu Jun 06 00:00:00 EDT 2019

cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.

The Journal of clinical investigation

Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X

Tue Aug 13 00:00:00 EDT 2019

Type I interferon induces CXCL13 to support ectopic germinal center formation.

The Journal of experimental medicine

Denton AE,Innocentin S,Carr EJ,Bradford BM,Lafouresse F,Mabbott NA,Mörbe U,Ludewig B,Groom JR,Good-Jacobson KL,Linterman MA

Mon Mar 04 00:00:00 EST 2019

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.

The Journal of experimental medicine

Weckbach LT,Grabmaier U,Uhl A,Gess S,Boehm F,Zehrer A,Pick R,Salvermoser M,Czermak T,Pircher J,Sorrelle N,Migliorini M,Strickland DK,Klingel K,Brinkmann V,Abu Abed U,Eriksson U,Massberg S,Brunner S,Walzog B

315-01A was used in In vivo experiments to report the presence of neutrophil extracellular traps in cardiac tissue of patients and mice with myocarditis.

Mon Feb 04 00:00:00 EST 2019

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.

The Journal of experimental medicine

315-01A was used in In vivo experiments to report the presence of neutrophil extracellular traps in cardiac tissue of patients and mice with myocarditis.

Mon Feb 04 00:00:00 EST 2019

Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.

The Journal of experimental medicine

Panicker N,Sarkar S,Harischandra DS,Neal M,Kam TI,Jin H,Saminathan H,Langley M,Charli A,Samidurai M,Rokad D,Ghaisas S,Pletnikova O,Dawson VL,Dawson TM,Anantharam V,Kanthasamy AG,Kanthasamy A

Mon Jun 03 00:00:00 EDT 2019

Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms.

Molecular psychiatry

Skelly DT,Griffin ÉW,Murray CL,Harney S,O'Boyle C,Hennessy E,Dansereau MA,Nazmi A,Tortorelli L,Rawlins JN,Bannerman DM,Cunningham C

Tue Oct 01 00:00:00 EDT 2019

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.

Cell death and differentiation

Sarhan J,Liu BC,Muendlein HI,Weindel CG,Smirnova I,Tang AY,Ilyukha V,Sorokin M,Buzdin A,Fitzgerald KA,Poltorak A

Tue Jan 01 00:00:00 EST 2019

Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging.

Aging cell

Yue S,Zheng X,Zheng Y

Thu Aug 01 00:00:00 EDT 2019

VISTA expressed in tumour cells regulates T cell function.

British journal of cancer

Mulati K,Hamanishi J,Matsumura N,Chamoto K,Mise N,Abiko K,Baba T,Yamaguchi K,Horikawa N,Murakami R,Taki M,Budiman K,Zeng X,Hosoe Y,Azuma M,Konishi I,Mandai M

Tue Jan 01 00:00:00 EST 2019

Characterization of the Effects of Mesenchymal Stromal Cells on Mouse and Human Islet Function.

Stem cells translational medicine

Arzouni AA,Vargas-Seymour A,Dhadda PK,Rackham CL,Huang GC,Choudhary P,King AJF,Jones PM

Sun Sep 01 00:00:00 EDT 2019

Putative Role of Nuclear Factor-Kappa B But Not Hypoxia-Inducible Factor-1α in Hypoxia-Dependent Regulation of Oxidative Stress in Hematopoietic Stem and Progenitor Cells.

Antioxidants & redox signaling

Halvarsson C,Rörby E,Eliasson P,Lang S,Soneji S,Jönsson JI

315-01A was used in Sample Preparation (FC/FACS) to investigate if HIF-1α protects hematopoietic stem cells against ROS.

Sat Jul 20 00:00:00 EDT 2019

Oncogenic Ras mutant causes the hyperactivation of NF-κB via acceleration of its transcriptional activation.

Molecular oncology

Tago K,Funakoshi-Tago M,Ohta S,Kawata H,Saitoh H,Horie H,Aoki-Ohmura C,Yamauchi J,Tanaka A,Matsugi J,Yanagisawa K

Fri Nov 01 00:00:00 EDT 2019

Signaling and functional competency of neutrophils derived from bone-marrow cells expressing the ER-HOXB8 oncoprotein.

Journal of leukocyte biology

Saul S,Castelbou C,Fickentscher C,Demaurex N

Fri Nov 01 00:00:00 EDT 2019

Delayed resolution of bleomycin-induced pulmonary fibrosis in absence of MMP13 (collagenase 3).

American journal of physiology. Lung cellular and molecular physiology

Cabrera S,Maciel M,Hernández-Barrientos D,Calyeca J,Gaxiola M,Selman M,Pardo A

315-01A was used in In vitro experiments to establish that MMP13 plays an antifibrotic role and its activity is crucial in lung repair and restoration of tissue integrity during fibrosis resolution.

Wed May 01 00:00:00 EDT 2019

Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells.

Stem cells (Dayton, Ohio)

Zuo R,Wang Y,Li J,Wu J,Wang W,Li B,Sun C,Wang Z,Shi C,Zhou Y,Liu M,Zhang C

Sat Jun 01 00:00:00 EDT 2019

USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1.

Journal of immunology (Baltimore, Md. : 1950)

Lei CQ,Wu X,Zhong X,Jiang L,Zhong B,Shu HB

315-01A was used in In vitro experiments to investigate ubiquitination of TAK1.

Mon Jul 01 00:00:00 EDT 2019

USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1.

Journal of immunology (Baltimore, Md. : 1950)

Lei CQ,Wu X,Zhong X,Jiang L,Zhong B,Shu HB

315-01A was used in In vitro experiments to investigate ubiquitination of TAK1.

Mon Jul 01 00:00:00 EDT 2019

c-Abl-Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory Genes.

Journal of immunology (Baltimore, Md. : 1950)

Bohio AA,Sattout A,Wang R,Wang K,Sah RK,Guo X,Zeng X,Ke Y,Boldogh I,Ba X

Sun Sep 15 00:00:00 EDT 2019

Gamma-secretase inhibitor suppressed Notch1 intracellular domain combination with p65 and resulted in the inhibition of the NF-κB signaling pathway induced by IL-1β and TNF-α in nucleus pulposus cells.

Journal of cellular biochemistry

Huang Y,Mei W,Chen J,Jiang T,Zhou Z,Yin G,Fan J

Fri Feb 01 00:00:00 EST 2019

Journal of cellular biochemistry

Huang Y,Mei W,Chen J,Jiang T,Zhou Z,Yin G,Fan J

Fri Feb 01 00:00:00 EST 2019

Intravitreal injection of adenosine A_2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice.

Scientific reports

Aires ID,Madeira MH,Boia R,Rodrigues-Neves AC,Martins JM,Ambrósio AF,Santiago AR

Wed Nov 20 00:00:00 EST 2019

Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins.

eLife

Lim J,Park H,Heisler J,Maculins T,Roose-Girma M,Xu M,Mckenzie B,van Lookeren Campagne M,Newton K,Murthy A

315-01A was used in In vitro experiments to demonstrate the role of autophagy in RIP homotypic interaction motif domain proteins.

Tue Jul 09 00:00:00 EDT 2019

PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells.

Scientific reports

Zhang KS,Schecker J,Krull A,Riechert E,Jürgensen L,Kamuf-Schenk V,Burghaus J,Kiper L,Cao Ho T,Wöltje K,Stangl V,Katus HA,Stangl K,Völkers M,Althoff TF

Thu Nov 14 00:00:00 EST 2019

Interleukin 34 (IL-34) cell-surface localization regulated by the molecular chaperone 78-kDa glucose-regulated protein facilitates the differentiation of monocytic cells.

The Journal of biological chemistry

Ogawa S,Matsuoka Y,Takada M,Matsui K,Yamane F,Kubota E,Yasuhara S,Hieda K,Kanayama N,Hatano N,Tokumitsu H,Magari M

Fri Feb 15 00:00:00 EST 2019

Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation.

Scientific reports

Dai D,Yuan J,Wang Y,Xu J,Mao C,Xiao Y

Wed May 29 00:00:00 EDT 2019

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.

Nature communications

Rosenbaum M,Gewies A,Pechloff K,Heuser C,Engleitner T,Gehring T,Hartjes L,Krebs S,Krappmann D,Kriegsmann M,Weichert W,Rad R,Kurts C,Ruland J

Tue May 28 00:00:00 EDT 2019

Caspase-1 initiates apoptosis in the absence of gasdermin D.

Nature communications

Tsuchiya K,Nakajima S,Hosojima S,Thi Nguyen D,Hattori T,Manh Le T,Hori O,Mahib MR,Yamaguchi Y,Miura M,Kinoshita T,Kushiyama H,Sakurai M,Shiroishi T,Suda T

Tue May 07 00:00:00 EDT 2019

G-protein Gα₁₃ functions as a cytoskeletal and mitochondrial regulator to restrain osteoclast function.

Scientific reports

Nakano S,Inoue K,Xu C,Deng Z,Syrovatkina V,Vitone G,Zhao L,Huang XY,Zhao B

Tue Mar 12 00:00:00 EDT 2019

Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3.

Cell death & disease

Lee SY,Kim H,Li CM,Kang J,Najafov A,Jung M,Kang S,Wang S,Yuan J,Jung YK

Wed Dec 04 00:00:00 EST 2019

Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3.

Cell death & disease

Lee SY,Kim H,Li CM,Kang J,Najafov A,Jung M,Kang S,Wang S,Yuan J,Jung YK

Wed Dec 04 00:00:00 EST 2019

Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model.

Cell death & disease

Rocchio F,Tapella L,Manfredi M,Chisari M,Ronco F,Ruffinatti FA,Conte E,Canonico PL,Sortino MA,Grilli M,Marengo E,Genazzani AA,Lim D

Thu Jan 10 00:00:00 EST 2019

Extracellular vesicles from T cells overexpress miR-146b-5p in HIV-1 infection and repress endothelial activation.

Scientific reports

Balducci E,Leroyer AS,Lacroix R,Robert S,Todorova D,Simoncini S,Lyonnet L,Chareyre C,Zaegel-Faucher O,Micallef J,Poizot-Martin I,Roll P,Dignat-George F

Tue Jul 16 00:00:00 EDT 2019

DOCK8 is expressed in microglia, and it regulates microglial activity during neurodegeneration in murine disease models.

The Journal of biological chemistry

Namekata K,Guo X,Kimura A,Arai N,Harada C,Harada T

Fri Sep 06 00:00:00 EDT 2019

MSC Transplantation Improves Lacrimal Gland Regeneration after Surgically Induced Dry Eye Disease in Mice.

Scientific reports

Dietrich J,Ott L,Roth M,Witt J,Geerling G,Mertsch S,Schrader S

Wed Dec 04 00:00:00 EST 2019

Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells.

Cell death & disease

Vig S,Buitinga M,Rondas D,Crèvecoeur I,van Zandvoort M,Waelkens E,Eizirik DL,Gysemans C,Baatsen P,Mathieu C,Overbergh L

Fri Apr 05 00:00:00 EDT 2019

Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells.

Cell death & disease

Vig S,Buitinga M,Rondas D,Crèvecoeur I,van Zandvoort M,Waelkens E,Eizirik DL,Gysemans C,Baatsen P,Mathieu C,Overbergh L

Fri Apr 05 00:00:00 EDT 2019

Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation.

Cell death & disease

Parker A,Vaux L,Patterson AM,Modasia A,Muraro D,Fletcher AG,Byrne HM,Maini PK,Watson AJM,Pin C

Wed Feb 06 00:00:00 EST 2019

Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson's disease.

Cell death & disease

Dionísio PA,Oliveira SR,Gaspar MM,Gama MJ,Castro-Caldas M,Amaral JD,Rodrigues CMP

Tue Nov 05 00:00:00 EST 2019

The protein tyrosine kinase SYK regulates the alternative p38 activation in liver during acute liver inflammation.

Scientific reports

Bang BR,Han KH,Seo GY,Croft M,Kang YJ

Thu Nov 28 00:00:00 EST 2019

Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α.

eLife

Li YT,Goswami D,Follmer M,Artz A,Pacheco-Blanco M,Vestweber D

315-01A was used in In vivo experiments to show that PILR-b1 on neutrophils and CD99 on endothelium represent a new pair of important players in the multistep cascade of leukocyte extravasation, which are needed to support the combined function of selectins, chemokines and integrins.

Tue Aug 06 00:00:00 EDT 2019

Pathogenic function of bystander-activated memory-like CD4⁺ T cells in autoimmune encephalomyelitis.

Nature communications

Lee HG,Lee JU,Kim DH,Lim S,Kang I,Choi JM

Tue Feb 12 00:00:00 EST 2019

IL-8 induces transdifferentiation of mature hepatocytes toward the cholangiocyte phenotype.

FEBS open bio

Sasaki T,Suzuki Y,Kakisaka K,Wang T,Ishida K,Suzuki A,Abe H,Sugai T,Takikawa Y

Sun Dec 01 00:00:00 EST 2019

Functional Screening Identifies MicroRNAs as Multi-Cellular Regulators of Heart Failure.

Scientific reports

Verjans R,Derks WJA,Korn K,Sönnichsen B,van Leeuwen REW,Schroen B,van Bilsen M,Heymans S

Mon Apr 15 00:00:00 EDT 2019

Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses.

Scientific reports

Minshawi F,White MRH,Muller W,Humphreys N,Jackson D,Campbell BJ,Adamson A,Papoutsopoulou S

Thu Jan 17 00:00:00 EST 2019

Innate immune memory in the brain shapes neurological disease hallmarks.

Nature

Wendeln AC,Degenhardt K,Kaurani L,Gertig M,Ulas T,Jain G,Wagner J,Häsler LM,Wild K,Skodras A,Blank T,Staszewski O,Datta M,Centeno TP,Capece V,Islam MR,Kerimoglu C,Staufenbiel M,Schultze JL,Beyer M,Prinz M,Jucker M,Fischer A,Neher JJ

Sun Apr 01 00:00:00 EDT 2018

Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.

Cell

Barrow AD,Edeling MA,Trifonov V,Luo J,Goyal P,Bohl B,Bando JK,Kim AH,Walker J,Andahazy M,Bugatti M,Melocchi L,Vermi W,Fremont DH,Cox S,Cella M,Schmedt C,Colonna M

Thu Jan 25 00:00:00 EST 2018

The BH3-only protein BAD mediates TNFα cytotoxicity despite concurrent activation of IKK and NF-κB in septic shock.

Cell research

Yan J,Zhang H,Xiang J,Zhao Y,Yuan X,Sun B,Lin A

Sun Jul 01 00:00:00 EDT 2018

T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.

Immunity

Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W

Tue Apr 17 00:00:00 EDT 2018

Macrophage TNF-α licenses donor T cells in murine bone marrow failure and can be implicated in human aplastic anemia.

Blood

Sun W,Wu Z,Lin Z,Hollinger M,Chen J,Feng X,Young NS

Thu Dec 27 00:00:00 EST 2018

Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling.

The Journal of experimental medicine

Kanaya T,Sakakibara S,Jinnohara T,Hachisuka M,Tachibana N,Hidano S,Kobayashi T,Kimura S,Iwanaga T,Nakagawa T,Katsuno T,Kato N,Akiyama T,Sato T,Williams IR,Ohno H

Mon Feb 05 00:00:00 EST 2018

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.

The Journal of experimental medicine

Song WM,Joshita S,Zhou Y,Ulland TK,Gilfillan S,Colonna M

Mon Mar 05 00:00:00 EST 2018

RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions.

The Journal of experimental medicine

Hogstad B,Berres ML,Chakraborty R,Tang J,Bigenwald C,Serasinghe M,Lim KPH,Lin H,Man TK,Remark R,Baxter S,Kana V,Jordan S,Karoulia Z,Kwan WH,Leboeuf M,Brandt E,Salmon H,McClain K,Poulikakos P,Chipuk J,Mulder WJM,Allen CE,Merad M

Tue Jan 02 00:00:00 EST 2018

Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance.

Autophagy

Lin SY,Hsieh SY,Fan YT,Wei WC,Hsiao PW,Tsai DH,Wu TS,Yang NS

315-01A was used in Cell Culture to investigate the possible mechanistic correlation between phytochemical shikonin-induced autophagy and the shikonin-induced necroptosis for tumor immunogenicity.

Thu Oct 03 00:00:00 EDT 2019

Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.

PLoS biology

Zhao J,Zhang L,Mu X,Doebelin C,Nguyen W,Wallace C,Reay DP,McGowan SJ,Corbo L,Clemens PR,Wilson GM,Watkins SC,Solt LA,Cameron MD,Huard J,Niedernhofer LJ,Kamenecka TM,Robbins PD

315-01A was used in Cell Culture to demonstrate that chronic treatment of a mouse model of Duchenne muscular dystrophy with two optimized lead NBD mimetics, attenuated inflammatory infiltration, necrosis and muscle degeneration, suggesting they are potential therapeutics for inflammatory and degenerative diseases.

Fri Jun 01 00:00:00 EDT 2018

Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy.

Oncogene

Mett V,Komarova EA,Greene K,Bespalov I,Brackett C,Gillard B,Gleiberman AS,Toshkov IA,Aygün-Sunar S,Johnson C,Karasik E,Bapardekar-Nair M,Kurnasov OV,Osterman AL,Stanhope-Baker PS,Morrison C,Moser MT,Foster BA,Gudkov AV

Thu Jan 25 00:00:00 EST 2018

MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells.

European journal of medicinal chemistry

Janganati V,Ponder J,Balasubramaniam M,Bhat-Nakshatri P,Bar EE,Nakshatri H,Jordan CT,Crooks PA

315-01A was used in In vitro experiments to investigate effects of triazole derivatives of melampomagnolide B on cancer growth inhibition.

Wed Sep 05 00:00:00 EDT 2018

Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion.

Journal of immunology (Baltimore, Md. : 1950)

Chen KW,Lawlor KE,von Pein JB,Boucher D,Gerlic M,Croker BA,Bezbradica JS,Vince JE,Schroder K

Tue May 15 00:00:00 EDT 2018

IVIg Promote Cross-Tolerance against Inflammatory Stimuli In Vitro and In Vivo.

Journal of immunology (Baltimore, Md. : 1950)

Domínguez-Soto Á,Simón-Fuentes M,de Las Casas-Engel M,Cuevas VD,López-Bravo M,Domínguez-Andrés J,Saz-Leal P,Sancho D,Ardavín C,Ochoa-Grullón J,Sánchez-Ramón S,Vega MA,Corbí AL

Sun Jul 01 00:00:00 EDT 2018

Lnc-chop Promotes Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor and Inflammatory Environments.

Journal of immunology (Baltimore, Md. : 1950)

Gao Y,Wang T,Li Y,Zhang Y,Yang R

Sun Apr 15 00:00:00 EDT 2018

Golgi Phosphoprotein 2 Is a Novel Regulator of IL-12 Production and Macrophage Polarization.

Journal of immunology (Baltimore, Md. : 1950)

Zhang W,Kim H,Lv J,Zhao N,Ma X

Thu Feb 15 00:00:00 EST 2018

Essential Role of Canonical NF-κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs.

Journal of immunology (Baltimore, Md. : 1950)

Bogdanova D,Takeuchi A,Ozawa M,Kanda Y,Rahman MA,Ludewig B,Kinashi T,Katakai T

Sat Dec 15 00:00:00 EST 2018

Effect of the proinflammatory cytokine TNF-α on intestinal riboflavin uptake: inhibition mediated via transcriptional mechanism(s).

American journal of physiology. Cell physiology

Anandam KY,Alwan OA,Subramanian VS,Srinivasan P,Kapadia R,Said HM

Thu Nov 01 00:00:00 EDT 2018

Effect of the proinflammatory cytokine TNF-α on intestinal riboflavin uptake: inhibition mediated via transcriptional mechanism(s).

American journal of physiology. Cell physiology

Anandam KY,Alwan OA,Subramanian VS,Srinivasan P,Kapadia R,Said HM

Thu Nov 01 00:00:00 EDT 2018

Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus.

Nature communications

Kim DH,Park ES,Lee AR,Park S,Park YK,Ahn SH,Kang HS,Won JH,Ha YN,Jae B,Kim DS,Chung WC,Song MJ,Kim KH,Park SH,Kim SH,Kim KH

315-01A was used in Western Blotting to suggest that IL-32γ functions as intracellular effector in hepatocytes for suppressing HBV replication to implicate a possible mechanism of non-cytopathic viral clearance.

Thu Aug 16 00:00:00 EDT 2018

Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus.

Nature communications

Kim DH,Park ES,Lee AR,Park S,Park YK,Ahn SH,Kang HS,Won JH,Ha YN,Jae B,Kim DS,Chung WC,Song MJ,Kim KH,Park SH,Kim SH,Kim KH

Thu Aug 16 00:00:00 EDT 2018

Bone protection by inhibition of microRNA-182.

Nature communications

Inoue K,Deng Z,Chen Y,Giannopoulou E,Xu R,Gong S,Greenblatt MB,Mangala LS,Lopez-Berestein G,Kirsch DG,Sood AK,Zhao L,Zhao B

Fri Oct 05 00:00:00 EDT 2018

SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α.

Nature communications

Mira E,Carmona-Rodríguez L,Pérez-Villamil B,Casas J,Fernández-Aceñero MJ,Martínez-Rey D,Martín-González P,Heras-Murillo I,Paz-Cabezas M,Tardáguila M,Oury TD,Martín-Puig S,Lacalle RA,Fabriás G,Díaz-Rubio E,Mañes S

Thu Feb 08 00:00:00 EST 2018

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation.

Cell death & disease

Faletti L,Peintner L,Neumann S,Sandler S,Grabinger T,Mac Nelly S,Merfort I,Huang CH,Tschaharganeh D,Kang TW,Heinzmann F,D'Artista L,Maurer U,Brunner T,Lowe S,Zender L,Borner C

Wed Sep 05 00:00:00 EDT 2018

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation.

Cell death & disease

Faletti L,Peintner L,Neumann S,Sandler S,Grabinger T,Mac Nelly S,Merfort I,Huang CH,Tschaharganeh D,Kang TW,Heinzmann F,D'Artista L,Maurer U,Brunner T,Lowe S,Zender L,Borner C

Wed Sep 05 00:00:00 EDT 2018

Necroptosis mediates myofibre death in dystrophin-deficient mice.

Nature communications

Morgan JE,Prola A,Mariot V,Pini V,Meng J,Hourde C,Dumonceaux J,Conti F,Relaix F,Authier FJ,Tiret L,Muntoni F,Bencze M

Fri Sep 07 00:00:00 EDT 2018

B-Cell Lymphoma 6 (BCL6) Is a Host Restriction Factor That Can Suppress HBV Gene Expression and Modulate Immune Responses.

Frontiers in microbiology

Lin CT,Hsieh YT,Yang YJ,Chen SH,Wu CH,Hwang LH

315-01A was used in In vitro experiments to study the cellular factors that help host cells to clear hepatitis B virus (HBV) during acute infection to show that B cell lymphoma 6 (BCL6) is a novel host restriction factor that exerts both anti-HBV and immunomodulatory activities.

Thu Oct 01 00:00:00 EDT 2020

B-Cell Lymphoma 6 (BCL6) Is a Host Restriction Factor That Can Suppress HBV Gene Expression and Modulate Immune Responses.

Frontiers in microbiology

Lin CT,Hsieh YT,Yang YJ,Chen SH,Wu CH,Hwang LH

Thu Oct 01 00:00:00 EDT 2020

Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model.

JCI insight

Flemming S,Luissint AC,Nusrat A,Parkos CA

315-01A was used in In vivo experiments to analyse leukocyte transepithelial migration using an in vivo murine colonic loop model.

Thu Oct 18 00:00:00 EDT 2018

Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration.

Cell death & disease

Gorth DJ,Shapiro IM,Risbud MV

Tue Dec 18 00:00:00 EST 2018

Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation.

Cell death discovery

Oliveira SR,Dionísio PA,Brito H,Franco L,Rodrigues CAB,Guedes RC,Afonso CAM,Amaral JD,Rodrigues CMP

Thu Oct 01 00:00:00 EDT 2020

ZBTB20 regulates EGFR expression and hepatocyte proliferation in mouse liver regeneration.

Cell death & disease

Zhang H,Shi JH,Jiang H,Wang K,Lu JY,Jiang X,Ma X,Chen YX,Ren AJ,Zheng J,Xie Z,Guo S,Xu X,Zhang WJ

Tue May 01 00:00:00 EDT 2018

Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models.

Nature communications

Sokhi UK,Liber MP,Frye L,Park S,Kang K,Pannellini T,Zhao B,Norinsky R,Ivashkiv LB,Gong S

Tue Feb 13 00:00:00 EST 2018

Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment.

Cell death & disease

Ruiz L,Gurlo T,Ravier MA,Wojtusciszyn A,Mathieu J,Brown MR,Broca C,Bertrand G,Butler PC,Matveyenko AV,Dalle S,Costes S

Tue May 22 00:00:00 EDT 2018

Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model.

Scientific reports

Henkel J,Coleman CD,Schraplau A,Jöhrens K,Weiss TS,Jonas W,Schürmann A,Püschel GP

Wed Oct 31 00:00:00 EDT 2018

ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.

Cell

Gong YN,Guy C,Olauson H,Becker JU,Yang M,Fitzgerald P,Linkermann A,Green DR

Thu Apr 06 00:00:00 EDT 2017

RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation.

Cell

Daniels BP,Snyder AG,Olsen TM,Orozco S,Oguin TH,Tait SWG,Martinez J,Gale M,Loo YM,Oberst A

315-01A was used in In vitro experiments to demonstrate that receptor-interacting protein kinase-3 restricts West Nile virus pathogenesis independently of cell death.

Thu Apr 06 00:00:00 EDT 2017

Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.

Immunity

Glodde N,Bald T,van den Boorn-Konijnenberg D,Nakamura K,O'Donnell JS,Szczepanski S,Brandes M,Eickhoff S,Das I,Shridhar N,Hinze D,Rogava M,van der Sluis TC,Ruotsalainen JJ,Gaffal E,Landsberg J,Ludwig KU,Wilhelm C,Riek-Burchardt M,Müller AJ,Gebhardt C,Scolyer RA,Long GV,Janzen V,Teng MWL,Kastenmüller W,Mazzone M,Smyth MJ,Tüting T,Hölzel M

Tue Oct 17 00:00:00 EDT 2017

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.

Immunity

Kishore M,Cheung KCP,Fu H,Bonacina F,Wang G,Coe D,Ward EJ,Colamatteo A,Jangani M,Baragetti A,Matarese G,Smith DM,Haas R,Mauro C,Wraith DC,Okkenhaug K,Catapano AL,De Rosa V,Norata GD,Marelli-Berg FM

315-01A was used in In vitro experiments to demonstrate that glucokinase-dependent glycolysis regulates regulatory T cell migration.

Tue Nov 21 00:00:00 EST 2017

Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis.

Immunity

Murata K,Fang C,Terao C,Giannopoulou EG,Lee YJ,Lee MJ,Mun SH,Bae S,Qiao Y,Yuan R,Furu M,Ito H,Ohmura K,Matsuda S,Mimori T,Matsuda F,Park-Min KH,Ivashkiv LB

Tue Jul 18 00:00:00 EDT 2017

Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis.

Cancer cell

Canli Ö,Nicolas AM,Gupta J,Finkelmeier F,Goncharova O,Pesic M,Neumann T,Horst D,Löwer M,Sahin U,Greten FR

Mon Dec 11 00:00:00 EST 2017

IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance.

Cell host & microbe

Tsai PY,Zhang B,He WQ,Zha JM,Odenwald MA,Singh G,Tamura A,Shen L,Sailer A,Yeruva S,Kuo WT,Fu YX,Tsukita S,Turner JR

315-01A was used in Cell Culture to investigate the pathogenic effects of diarrhea.

Wed Jun 14 00:00:00 EDT 2017

Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration.

The Journal of experimental medicine

Badran YR,Dedeoglu F,Leyva Castillo JM,Bainter W,Ohsumi TK,Bousvaros A,Goldsmith JD,Geha RS,Chou J

Mon Jul 03 00:00:00 EDT 2017

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.

The Journal of experimental medicine

Matsuzawa-Ishimoto Y,Shono Y,Gomez LE,Hubbard-Lucey VM,Cammer M,Neil J,Dewan MZ,Lieberman SR,Lazrak A,Marinis JM,Beal A,Harris PA,Bertin J,Liu C,Ding Y,van den Brink MRM,Cadwell K

Mon Dec 04 00:00:00 EST 2017

Subversion of NK-cell and TNFα Immune Surveillance Drives Tumor Recurrence.

Cancer immunology research

Kottke T,Evgin L,Shim KG,Rommelfanger D,Boisgerault N,Zaidi S,Diaz RM,Thompson J,Ilett E,Coffey M,Selby P,Pandha H,Harrington K,Melcher A,Vile R

315-01A was used in Cell Culture to investigate TNFα and immune activation in minimal residual disease recurrence.

Wed Nov 01 00:00:00 EDT 2017

Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ.

Frontiers in immunology

Kurena B,Müller E,Christopoulos PF,Johnsen IB,Stankovic B,Øynebråten I,Corthay A,Zajakina A

315-01A was used in Sample Preparation (FC/FACS) to evaluate the antitumour ability of Semliki Forest virus vectors expressing TNF-α or IFN-γ.

Wed Nov 20 00:00:00 EST 2019

Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease.

Journal of immunology (Baltimore, Md. : 1950)

Bradford EM,Ryu SH,Singh AP,Lee G,Goretsky T,Sinh P,Williams DB,Cloud AL,Gounaris E,Patel V,Lamping OF,Lynch EB,Moyer MP,De Plaen IG,Shealy DJ,Yang GY,Barrett TA

Fri Sep 01 00:00:00 EDT 2017

Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease.

Journal of immunology (Baltimore, Md. : 1950)

Bradford EM,Ryu SH,Singh AP,Lee G,Goretsky T,Sinh P,Williams DB,Cloud AL,Gounaris E,Patel V,Lamping OF,Lynch EB,Moyer MP,De Plaen IG,Shealy DJ,Yang GY,Barrett TA

Fri Sep 01 00:00:00 EDT 2017

Naringenin Ameliorates Acute Inflammation by Regulating Intracellular Cytokine Degradation.

Journal of immunology (Baltimore, Md. : 1950)

Jin L,Zeng W,Zhang F,Zhang C,Liang W

Wed Nov 15 00:00:00 EST 2017

Crucial Role for Immune Complexes but Not FcRn in Immunization against Anti-TNF-α Antibodies after a Single Injection in Mice.

Journal of immunology (Baltimore, Md. : 1950)

Arnoult C,Brachet G,Cadena Castaneda D,Azzopardi N,Passot C,Desvignes C,Paintaud G,Heuzé-Vourc'h N,Watier H,Gouilleux-Gruart V

Sat Jul 15 00:00:00 EDT 2017

Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.

NPJ Parkinson's disease

Sarkar S,Malovic E,Harishchandra DS,Ghaisas S,Panicker N,Charli A,Palanisamy BN,Rokad D,Jin H,Anantharam V,Kanthasamy A,Kanthasamy AG

Wed Sep 30 00:00:00 EDT 2020

A trimeric structural fusion of an antagonistic tumor necrosis factor-α mutant enhances molecular stability and enables facile modification.

The Journal of biological chemistry

Inoue M,Ando D,Kamada H,Taki S,Niiyama M,Mukai Y,Tadokoro T,Maenaka K,Nakayama T,Kado Y,Inoue T,Tsutsumi Y,Tsunoda SI

Fri Apr 21 00:00:00 EDT 2017

Tolerogenic dendritic cells are efficiently generated using minocycline and dexamethasone.

Scientific reports

Lee JH,Park CS,Jang S,Kim JW,Kim SH,Song S,Kim K,Lee CK

Wed Nov 08 00:00:00 EST 2017

The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis.

Nature communications

Fusella F,Seclì L,Busso E,Krepelova A,Moiso E,Rocca S,Conti L,Annaratone L,Rubinetto C,Mello-Grand M,Singh V,Chiorino G,Silengo L,Altruda F,Turco E,Morotti A,Oliviero S,Castellano I,Cavallo F,Provero P,Tarone G,Brancaccio M

Tue Nov 21 00:00:00 EST 2017

The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction.

Scientific reports

Nagasaka A,Mogi C,Ono H,Nishi T,Horii Y,Ohba Y,Sato K,Nakaya M,Okajima F,Kurose H

Thu Aug 10 00:00:00 EDT 2017

Grape-seed Polyphenols Play a Protective Role in Elastase-induced Abdominal Aortic Aneurysm in Mice.

Scientific reports

Wang C,Wang Y,Yu M,Chen C,Xu L,Cao Y,Qi R

Thu Aug 24 00:00:00 EDT 2017

C-X-C motif chemokine ligand 10 produced by mouse Sertoli cells in response to mumps virus infection induces male germ cell apoptosis.

Cell death & disease

Jiang Q,Wang F,Shi L,Zhao X,Gong M,Liu W,Song C,Li Q,Chen Y,Wu H,Han D

Thu Oct 26 00:00:00 EDT 2017

DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.

Cell

Herrtwich L,Nanda I,Evangelou K,Nikolova T,Horn V,Erny D,Stefanowski J,Rogell L,Klein C,Gharun K,Follo M,Seidl M,Kremer B,Münke N,Senges J,Fliegauf M,Aschman T,Pfeifer D,Sarrazin S,Sieweke MH,Wagner D,Dierks C,Haaf T,Ness T,Zaiss MM,Voll RE,Deshmukh SD,Prinz M,Goldmann T,Hölscher C,Hauser AE,Lopez-Contreras AJ,Grün D,Gorgoulis V,Diefenbach A,Henneke P,Triantafyllopoulou A

Thu Nov 17 00:00:00 EST 2016

Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.

Immunity

Bhattacharya N,Yuan R,Prestwood TR,Penny HL,DiMaio MA,Reticker-Flynn NE,Krois CR,Kenkel JA,Pham TD,Carmi Y,Tolentino L,Choi O,Hulett R,Wang J,Winer DA,Napoli JL,Engleman EG

Tue Sep 20 00:00:00 EDT 2016

Donor dendritic cell-derived exosomes promote allograft-targeting immune response.

The Journal of clinical investigation

Liu Q,Rojas-Canales DM,Divito SJ,Shufesky WJ,Stolz DB,Erdos G,Sullivan ML,Gibson GA,Watkins SC,Larregina AT,Morelli AE

Mon Aug 01 00:00:00 EDT 2016

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation.

The Journal of clinical investigation

Kim M,Allen B,Korhonen EA,Nitschké M,Yang HW,Baluk P,Saharinen P,Alitalo K,Daly C,Thurston G,McDonald DM

Thu Sep 01 00:00:00 EDT 2016

Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis.

Arthritis & rheumatology (Hoboken, N.J.)

Ismail HM,Miotla-Zarebska J,Troeberg L,Tang X,Stott B,Yamamoto K,Nagase H,Fosang AJ,Vincent TL,Saklatvala J

315-01A was used in In vitro experiments to demonstrate that JNK-2 regulates aggrecan degradation in cultured murine cartilage and surgically induced OA in vivo following mechanical destabilization of the knee joint.

Sun May 01 00:00:00 EDT 2016

Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner.

Cell death and differentiation

Preyat N,Rossi M,Kers J,Chen L,Bertin J,Gough PJ,Le Moine A,Rongvaux A,Van Gool F,Leo O

315-01A was used in Sample Preparation (Western Blotting) to show that intracellular NAD(+) does not represent a universal pro-survival factor, but rather acts as a key metabolite regulating the choice of cell demise in response to both intrinsic and extrinsic factors.

Fri Jan 01 00:00:00 EST 2016

A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer.

Oncogene

Moles A,Butterworth JA,Sanchez A,Hunter JE,Leslie J,Sellier H,Tiniakos D,Cockell SJ,Mann DA,Oakley F,Perkins ND

Thu Sep 01 00:00:00 EDT 2016

Differentiation of Vascular Stem Cells Contributes to Ectopic Calcification of Atherosclerotic Plaque.

Stem cells (Dayton, Ohio)

Leszczynska A,O'Doherty A,Farrell E,Pindjakova J,O'Brien FJ,O'Brien T,Barry F,Murphy M

Fri Apr 01 00:00:00 EDT 2016

TNF-α Inhibits FoxO1 by Upregulating miR-705 to Aggravate Oxidative Damage in Bone Marrow-Derived Mesenchymal Stem Cells during Osteoporosis.

Stem cells (Dayton, Ohio)

Liao L,Su X,Yang X,Hu C,Li B,Lv Y,Shuai Y,Jing H,Deng Z,Jin Y

Fri Apr 01 00:00:00 EDT 2016

IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance.

Journal of immunology (Baltimore, Md. : 1950)

Patin EC,Jones AV,Thompson A,Clement M,Liao CT,Griffiths JS,Wallace LE,Bryant CE,Lang R,Rosenstiel P,Humphreys IR,Taylor PR,Jones GW,Orr SJ

Fri Jul 01 00:00:00 EDT 2016

Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice.

Journal of immunology (Baltimore, Md. : 1950)

Niu S,Bian Z,Tremblay A,Luo Y,Kidder K,Mansour A,Zen K,Liu Y

Sat Oct 15 00:00:00 EDT 2016

Low-Intensity Focused Ultrasound Induces Reversal of Tumor-Induced T Cell Tolerance and Prevents Immune Escape.

Journal of immunology (Baltimore, Md. : 1950)

Bandyopadhyay S,Quinn TJ,Scandiuzzi L,Basu I,Partanen A,Tomé WA,Macian F,Guha C

Mon Feb 15 00:00:00 EST 2016

γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling.

The Journal of biological chemistry

Chhibber-Goel J,Coleman-Vaughan C,Agrawal V,Sawhney N,Hickey E,Powell JC,McCarthy JV

Fri Mar 11 00:00:00 EST 2016

γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling.

The Journal of biological chemistry

Chhibber-Goel J,Coleman-Vaughan C,Agrawal V,Sawhney N,Hickey E,Powell JC,McCarthy JV

Fri Mar 11 00:00:00 EST 2016

Monocytic MKP-1 is a Sensor of the Metabolic Environment and Regulates Function and Phenotypic Fate of Monocyte-Derived Macrophages in Atherosclerosis.

Scientific reports

Kim HS,Tavakoli S,Piefer LA,Nguyen HN,Asmis R

Tue Sep 27 00:00:00 EDT 2016

Roles of endothelial A-type lamins in migration of T cells on and under endothelial layers.

Scientific reports

Song KH,Lee J,Park H,Kim HM,Park J,Kwon KW,Doh J

Mon Mar 21 00:00:00 EDT 2016

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.

Nature communications

Göbel K,Pankratz S,Asaridou CM,Herrmann AM,Bittner S,Merker M,Ruck T,Glumm S,Langhauser F,Kraft P,Krug TF,Breuer J,Herold M,Gross CC,Beckmann D,Korb-Pap A,Schuhmann MK,Kuerten S,Mitroulis I,Ruppert C,Nolte MW,Panousis C,Klotz L,Kehrel B,Korn T,Langer HF,Pap T,Nieswandt B,Wiendl H,Chavakis T,Kleinschnitz C,Meuth SG

Wed May 18 00:00:00 EDT 2016

Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro.

The Journal of biological chemistry

Loeven MA,Rops AL,Lehtinen MJ,van Kuppevelt TH,Daha MR,Smith RJ,Bakker M,Berden JH,Rabelink TJ,Jokiranta TS,van der Vlag J

Fri Mar 04 00:00:00 EST 2016

Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis.

Nature communications

Poulos MG,Ramalingam P,Gutkin MC,Kleppe M,Ginsberg M,Crowley MJP,Elemento O,Levine RL,Rafii S,Kitajewski J,Greenblatt MB,Shim JH,Butler JM

Wed Dec 21 00:00:00 EST 2016

The Journal of biological chemistry

Luo MC,Zhou SY,Feng DY,Xiao J,Li WY,Xu CD,Wang HY,Zhou T

Fri Oct 14 00:00:00 EDT 2016

Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells.

Nature communications

Zhao Y,Chu X,Chen J,Wang Y,Gao S,Jiang Y,Zhu X,Tan G,Zhao W,Yi H,Xu H,Ma X,Lu Y,Yi Q,Wang S

Fri Aug 05 00:00:00 EDT 2016

Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.

The Journal of biological chemistry

Mei ZZ,Chen XY,Hu SW,Wang N,Ou XL,Wang J,Luo HH,Liu J,Jiang Y

Fri Aug 26 00:00:00 EDT 2016

Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity.

Scientific reports

Pepin M,Mezouar S,Pegon J,Muczynski V,Adam F,Bianchini EP,Bazaa A,Proulle V,Rupin A,Paysant J,Panicot-Dubois L,Christophe OD,Dubois C,Lenting PJ,Denis CV

Mon Nov 28 00:00:00 EST 2016

RIPK1 protects from TNF-α-mediated liver damage during hepatitis.

Cell death & disease

Filliol A,Piquet-Pellorce C,Le Seyec J,Farooq M,Genet V,Lucas-Clerc C,Bertin J,Gough PJ,Dimanche-Boitrel MT,Vandenabeele P,Bertrand MJ,Samson M

Thu Nov 10 00:00:00 EST 2016

RIPK1 protects from TNF-α-mediated liver damage during hepatitis.

Cell death & disease

Filliol A,Piquet-Pellorce C,Le Seyec J,Farooq M,Genet V,Lucas-Clerc C,Bertin J,Gough PJ,Dimanche-Boitrel MT,Vandenabeele P,Bertrand MJ,Samson M

Thu Nov 10 00:00:00 EST 2016

Modulation of IL-6 induced RANKL expression in arthritic synovium by a transcription factor SOX5.

Scientific reports

Feng X,Shi Y,Xu L,Peng Q,Wang F,Wang X,Sun W,Lu Y,Tsao BP,Zhang M,Tan W

315-01A was used in Tissue/Organ culture to study the regulation of SOX5 levels in relation to receptor activator of nuclear factor κB ligand (RANKL) expression in rheumatoid arthritis (RA) in synovial fibroblasts (SF) and the development of bone erosion in the collagen-induced arthritis (CIA) mouse.

Tue Aug 23 00:00:00 EDT 2016

Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport.

Scientific reports

Song S,Faleo G,Yeung R,Kant R,Posselt AM,Desai TA,Tang Q,Roy S

Thu Mar 24 00:00:00 EDT 2016

Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response.

The Journal of biological chemistry

Pasi S,Kant R,Surolia A

Fri Jun 03 00:00:00 EDT 2016

TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis.

Scientific reports

Chen X,Nie Y,Xiao H,Bian Z,Scarzello AJ,Song NY,Trivett AL,Yang D,Oppenheim JJ

Wed Sep 07 00:00:00 EDT 2016

Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells.

Scientific reports

Sonoda S,Yamaza H,Ma L,Tanaka Y,Tomoda E,Aijima R,Nonaka K,Kukita T,Shi S,Nishimura F,Yamaza T

Mon Jan 18 00:00:00 EST 2016

Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling.

Biochemical and biophysical research communications

Emmerich CH,Bakshi S,Kelsall IR,Ortiz-Guerrero J,Shpiro N,Cohen P

315-01A was used in In vitro experiments to report that TNFα induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain.

Fri Jun 03 00:00:00 EDT 2016

Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.

Nature

Carmi Y,Spitzer MH,Linde IL,Burt BM,Prestwood TR,Perlman N,Davidson MG,Kenkel JA,Segal E,Pusapati GV,Bhattacharya N,Engleman EG

Thu May 07 00:00:00 EDT 2015

Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.

Nature

Carmi Y,Spitzer MH,Linde IL,Burt BM,Prestwood TR,Perlman N,Davidson MG,Kenkel JA,Segal E,Pusapati GV,Bhattacharya N,Engleman EG

Thu May 07 00:00:00 EDT 2015

CRK proteins selectively regulate T cell migration into inflamed tissues.

The Journal of clinical investigation

Huang Y,Clarke F,Karimi M,Roy NH,Williamson EK,Okumura M,Mochizuki K,Chen EJ,Park TJ,Debes GF,Zhang Y,Curran T,Kambayashi T,Burkhardt JK

Mon Mar 02 00:00:00 EST 2015

Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.

The Journal of clinical investigation

Leoni G,Neumann PA,Kamaly N,Quiros M,Nishio H,Jones HR,Sumagin R,Hilgarth RS,Alam A,Fredman G,Argyris I,Rijcken E,Kusters D,Reutelingsperger C,Perretti M,Parkos CA,Farokhzad OC,Neish AS,Nusrat A

Mon Mar 02 00:00:00 EST 2015

MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.

The Journal of clinical investigation

Li D,Wang A,Liu X,Meisgen F,Grünler J,Botusan IR,Narayanan S,Erikci E,Li X,Blomqvist L,Du L,Pivarcsi A,Sonkoly E,Chowdhury K,Catrina SB,Ståhle M,Landén NX

Mon Aug 03 00:00:00 EDT 2015

Brain endothelial TAK1 and NEMO safeguard the neurovascular unit.

The Journal of experimental medicine

Ridder DA,Wenzel J,Müller K,Töllner K,Tong XK,Assmann JC,Stroobants S,Weber T,Niturad C,Fischer L,Lembrich B,Wolburg H,Grand'Maison M,Papadopoulos P,Korpos E,Truchetet F,Rades D,Sorokin LM,Schmidt-Supprian M,Bedell BJ,Pasparakis M,Balschun D,D'Hooge R,Löscher W,Hamel E,Schwaninger M

Mon Sep 21 00:00:00 EDT 2015

Antitumor immunity triggered by melphalan is potentiated by melanoma cell surface-associated calreticulin.

Cancer research

Dudek-Perić AM,Ferreira GB,Muchowicz A,Wouters J,Prada N,Martin S,Kiviluoto S,Winiarska M,Boon L,Mathieu C,van den Oord J,Stas M,Gougeon ML,Golab J,Garg AD,Agostinis P

315-01A was used in Cell Culture to illustrate how melphalan triggers inflammatory cell death that can be leveraged by immunomodulators.

Wed Apr 15 00:00:00 EDT 2015

CD31 signals confer immune privilege to the vascular endothelium.

Proceedings of the National Academy of Sciences of the United States of America

Cheung K,Ma L,Wang G,Coe D,Ferro R,Falasca M,Buckley CD,Mauro C,Marelli-Berg FM

Tue Oct 27 00:00:00 EDT 2015

RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

Proceedings of the National Academy of Sciences of the United States of America

Ohshima J,Sasai M,Liu J,Yamashita K,Ma JS,Lee Y,Bando H,Howard JC,Ebisu S,Hayashi M,Takeda K,Standley DM,Frickel EM,Yamamoto M

Tue Aug 18 00:00:00 EDT 2015

IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs.

Proceedings of the National Academy of Sciences of the United States of America

Barone F,Nayar S,Campos J,Cloake T,Withers DR,Toellner KM,Zhang Y,Fouser L,Fisher B,Bowman S,Rangel-Moreno J,Garcia-Hernandez Mde L,Randall TD,Lucchesi D,Bombardieri M,Pitzalis C,Luther SA,Buckley CD

Tue Sep 01 00:00:00 EDT 2015

Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6.

Proceedings of the National Academy of Sciences of the United States of America

Lin D,Zhang M,Zhang MX,Ren Y,Jin J,Zhao Q,Pan Z,Wu M,Shu HB,Dong C,Zhong B

Tue Sep 08 00:00:00 EDT 2015

Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system.

Glia

Grill M,Syme TE,Noçon AL,Lu AZ,Hancock D,Rose-John S,Campbell IL

Thu Oct 01 00:00:00 EDT 2015

MicroRNA-100-5p indirectly modulates the expression of Il6, Ptgs1/2 and Tlr4 mRNA in the mouse follicular dendritic cell-like cell line, FL-Y.

Immunology

Aungier SR,Ohmori H,Clinton M,Mabbott NA

Thu Jan 01 00:00:00 EST 2015

Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptor α.

Journal of lipid research

Takahashi H,Goto T,Yamazaki Y,Kamakari K,Hirata M,Suzuki H,Shibata D,Nakata R,Inoue H,Takahashi N,Kawada T

Sun Feb 01 00:00:00 EST 2015

Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation.

Cancer science

Takahashi K,Nagai N,Ogura K,Tsuneyama K,Saiki I,Irimura T,Hayakawa Y

Wed Jul 01 00:00:00 EDT 2015

Pretreatment of Mesenchymal Stem Cells Manipulates Their Vasculoprotective Potential While Not Altering Their Homing Within the Injured Gut.

Stem cells (Dayton, Ohio)

Kavanagh DP,Suresh S,Newsome PN,Frampton J,Kalia N

Tue Sep 01 00:00:00 EDT 2015

K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling.

Journal of immunology (Baltimore, Md. : 1950)

Katsnelson MA,Rucker LG,Russo HM,Dubyak GR

Wed Apr 15 00:00:00 EDT 2015

Cryptococcus neoformans-induced macrophage lysosome damage crucially contributes to fungal virulence.

Journal of immunology (Baltimore, Md. : 1950)

Davis MJ,Eastman AJ,Qiu Y,Gregorka B,Kozel TR,Osterholzer JJ,Curtis JL,Swanson JA,Olszewski MA

Sun Mar 01 00:00:00 EST 2015

Tissue-Specific Regulation of p38α-Mediated Inflammation in Con A-Induced Acute Liver Damage.

Journal of immunology (Baltimore, Md. : 1950)

Kang YJ,Bang BR,Otsuka M,Otsu K

Fri May 15 00:00:00 EDT 2015

Mutation in the CD45 inhibitory wedge modulates integrin activation and leukocyte recruitment during inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Germena G,Volmering S,Sohlbach C,Zarbock A

Thu Jan 15 00:00:00 EST 2015

CIKS/DDX3X interaction controls the stability of the Zc3h12a mRNA induced by IL-17.

Journal of immunology (Baltimore, Md. : 1950)

Somma D,Mastrovito P,Grieco M,Lavorgna A,Pignalosa A,Formisano L,Salzano AM,Scaloni A,Pacifico F,Siebenlist U,Leonardi A

Wed Apr 01 00:00:00 EDT 2015

IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Shimizu K,Nakajima A,Sudo K,Liu Y,Mizoroki A,Ikarashi T,Horai R,Kakuta S,Watanabe T,Iwakura Y

Wed Apr 01 00:00:00 EDT 2015

Delinking CARD9 and IL-17: CARD9 Protects against Candida tropicalis Infection through a TNF-α-Dependent, IL-17-Independent Mechanism.

Journal of immunology (Baltimore, Md. : 1950)

Whibley N,Jaycox JR,Reid D,Garg AV,Taylor JA,Clancy CJ,Nguyen MH,Biswas PS,McGeachy MJ,Brown GD,Gaffen SL

Thu Oct 15 00:00:00 EDT 2015

IκBNS regulates murine Th17 differentiation during gut inflammation and infection.

Journal of immunology (Baltimore, Md. : 1950)

Annemann M,Wang Z,Plaza-Sirvent C,Glauben R,Schuster M,Ewald Sander F,Mamareli P,Kühl AA,Siegmund B,Lochner M,Schmitz I

Sun Mar 15 00:00:00 EDT 2015

DCIR maintains bone homeostasis by regulating IFN-γ production in T cells.

Journal of immunology (Baltimore, Md. : 1950)

Maruhashi T,Kaifu T,Yabe R,Seno A,Chung SH,Fujikado N,Iwakura Y

Mon Jun 15 00:00:00 EDT 2015

Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling.

Nature communications

Kang YJ,Bang BR,Han KH,Hong L,Shim EJ,Ma J,Lerner RA,Otsuka M

Fri Sep 18 00:00:00 EDT 2015

Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B.

Scientific reports

Pacios S,Xiao W,Mattos M,Lim J,Tarapore RS,Alsadun S,Yu B,Wang CY,Graves DT

Tue Dec 15 00:00:00 EST 2015

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.

Nature communications

Matsuda T,Murao N,Katano Y,Juliandi B,Kohyama J,Akira S,Kawai T,Nakashima K

Mon Mar 09 00:00:00 EDT 2015

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.

Nature communications

Matsuda T,Murao N,Katano Y,Juliandi B,Kohyama J,Akira S,Kawai T,Nakashima K

Mon Mar 09 00:00:00 EDT 2015

Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction.

PloS one

Bremser A,Brack M,Izcue A

315-01A was used in Cell Culture to investigate the effects of TCR signals on T cells through studying the expression of T cell activation marker CD69.

Tue May 24 00:00:00 EDT 2016

SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell.

The Journal of biological chemistry

Fujimaki K,Ogihara T,Morris DL,Oda H,Iida H,Fujitani Y,Mirmira RG,Evans-Molina C,Watada H

Fri Jul 03 00:00:00 EDT 2015

Chronic inflammation aggravates metabolic disorders of hepatic fatty acids in high-fat diet-induced obese mice.

Scientific reports

Zhao L,Zhong S,Qu H,Xie Y,Cao Z,Li Q,Yang P,Varghese Z,Moorhead JF,Chen Y,Ruan XZ

Thu May 14 00:00:00 EDT 2015

Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes.

Scientific reports

Yamamoto S,Niida S,Azuma E,Yanagibashi T,Muramatsu M,Huang TT,Sagara H,Higaki S,Ikutani M,Nagai Y,Takatsu K,Miyazaki K,Hamashima T,Mori H,Matsuda N,Ishii Y,Sasahara M

Tue Feb 17 00:00:00 EST 2015

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.

Cell death & disease

Fauster A,Rebsamen M,Huber KV,Bigenzahn JW,Stukalov A,Lardeau CH,Scorzoni S,Bruckner M,Gridling M,Parapatics K,Colinge J,Bennett KL,Kubicek S,Krautwald S,Linkermann A,Superti-Furga G

Thu May 21 00:00:00 EDT 2015

Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction.

The Journal of biological chemistry

Park ES,Choi S,Shin B,Yu J,Yu J,Hwang JM,Yun H,Chung YH,Choi JS,Choi Y,Rho J

Fri Apr 10 00:00:00 EDT 2015

Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors.

The Journal of biological chemistry

Pontejo SM,Alejo A,Alcami A

Fri Jun 26 00:00:00 EDT 2015

The TLR2 is activated by sporozoites and suppresses intrahepatic rodent malaria parasite development.

Scientific reports

Zheng H,Tan Z,Zhou T,Zhu F,Ding Y,Liu T,Wu Y,Xu W

Tue Dec 15 00:00:00 EST 2015

Is SIRT2 required for necroptosis?

Nature

Newton K,Hildebrand JM,Shen Z,Rodriguez D,Alvarez-Diaz S,Petersen S,Shah S,Dugger DL,Huang C,Auwerx J,Vandenabeele P,Green DR,Ashkenazi A,Dixit VM,Kaiser WJ,Strasser A,Degterev A,Silke J

Thu Feb 27 00:00:00 EST 2014

A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.

Nature

Murthy A,Li Y,Peng I,Reichelt M,Katakam AK,Noubade R,Roose-Girma M,DeVoss J,Diehl L,Graham RR,van Lookeren Campagne M

Thu Feb 27 00:00:00 EST 2014

A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.

Nature

Murthy A,Li Y,Peng I,Reichelt M,Katakam AK,Noubade R,Roose-Girma M,DeVoss J,Diehl L,Graham RR,van Lookeren Campagne M

Thu Feb 27 00:00:00 EST 2014

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma.

Nature

Bald T,Quast T,Landsberg J,Rogava M,Glodde N,Lopez-Ramos D,Kohlmeyer J,Riesenberg S,van den Boorn-Konijnenberg D,Hömig-Hölzel C,Reuten R,Schadow B,Weighardt H,Wenzel D,Helfrich I,Schadendorf D,Bloch W,Bianchi ME,Lugassy C,Barnhill RL,Koch M,Fleischmann BK,Förster I,Kastenmüller W,Kolanus W,Hölzel M,Gaffal E,Tüting T

Thu Mar 06 00:00:00 EST 2014

An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation.

Cell

Baruch M,Belotserkovsky I,Hertzog BB,Ravins M,Dov E,McIver KS,Le Breton YS,Zhou Y,Cheng CY,Hanski E

Thu Jan 16 00:00:00 EST 2014

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.

Cell

Dillon CP,Weinlich R,Rodriguez DA,Cripps JG,Quarato G,Gurung P,Verbist KC,Brewer TL,Llambi F,Gong YN,Janke LJ,Kelliher MA,Kanneganti TD,Green DR

Thu May 22 00:00:00 EDT 2014

Endothelial C-type natriuretic peptide maintains vascular homeostasis.

The Journal of clinical investigation

Moyes AJ,Khambata RS,Villar I,Bubb KJ,Baliga RS,Lumsden NG,Xiao F,Gane PJ,Rebstock AS,Worthington RJ,Simone MI,Mota F,Rivilla F,Vallejo S,Peiró C,Sánchez Ferrer CF,Djordjevic S,Caulfield MJ,MacAllister RJ,Selwood DL,Ahluwalia A,Hobbs AJ

Mon Sep 01 00:00:00 EDT 2014

RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis.

The Journal of clinical investigation

Li S,Miller CH,Giannopoulou E,Hu X,Ivashkiv LB,Zhao B

Sat Nov 01 00:00:00 EDT 2014

Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.

The Journal of clinical investigation

Choi SH,Kim BG,Robinson J,Fink S,Yan M,Sporn MB,Markowitz SD,Letterio JJ

Sun Jun 01 00:00:00 EDT 2014

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.

The Journal of experimental medicine

Farin HF,Karthaus WR,Kujala P,Rakhshandehroo M,Schwank G,Vries RG,Kalkhoven E,Nieuwenhuis EE,Clevers H

Mon Jun 30 00:00:00 EDT 2014

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.

The Journal of experimental medicine

Kovács M,Németh T,Jakus Z,Sitaru C,Simon E,Futosi K,Botz B,Helyes Z,Lowell CA,Mócsai A

Mon Sep 22 00:00:00 EDT 2014

IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms.

Proceedings of the National Academy of Sciences of the United States of America

Ha HL,Wang H,Pisitkun P,Kim JC,Tassi I,Tang W,Morasso MI,Udey MC,Siebenlist U

Tue Aug 19 00:00:00 EDT 2014

Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.

Proceedings of the National Academy of Sciences of the United States of America

Gobbetti T,Coldewey SM,Chen J,McArthur S,le Faouder P,Cenac N,Flower RJ,Thiemermann C,Perretti M

Tue Dec 30 00:00:00 EST 2014

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.

Proceedings of the National Academy of Sciences of the United States of America

Kaiser WJ,Daley-Bauer LP,Thapa RJ,Mandal P,Berger SB,Huang C,Sundararajan A,Guo H,Roback L,Speck SH,Bertin J,Gough PJ,Balachandran S,Mocarski ES

Tue May 27 00:00:00 EDT 2014

Small interfering RNA targeting nerve growth factor alleviates allergic airway hyperresponsiveness.

Molecular therapy. Nucleic acids

Chen YL,Huang HY,Lee CC,Chiang BL

Tue Apr 08 00:00:00 EDT 2014

TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state.

Oncogene

Mori T,Sato Y,Miyamoto K,Kobayashi T,Shimizu T,Kanagawa H,Katsuyama E,Fujie A,Hao W,Tando T,Iwasaki R,Kawana H,Morioka H,Matsumoto M,Saya H,Toyama Y,Miyamoto T

Thu Aug 14 00:00:00 EDT 2014

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation.

The Journal of cell biology

Morioka S,Broglie P,Omori E,Ikeda Y,Takaesu G,Matsumoto K,Ninomiya-Tsuji J

Mon Feb 17 00:00:00 EST 2014

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation.

The Journal of cell biology

Morioka S,Broglie P,Omori E,Ikeda Y,Takaesu G,Matsumoto K,Ninomiya-Tsuji J

Mon Feb 17 00:00:00 EST 2014

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation.

The Journal of cell biology

Morioka S,Broglie P,Omori E,Ikeda Y,Takaesu G,Matsumoto K,Ninomiya-Tsuji J

Mon Feb 17 00:00:00 EST 2014

Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways.

The American journal of pathology

Baluk P,Phillips K,Yao LC,Adams A,Nitschké M,McDonald DM

315-01A was used in In vivo experiments to demonstrate that neutrophil influx is required for remodeling of capillaries into venules in the airways of Mycoplasma-infected mice.

Sun Jun 01 00:00:00 EDT 2014

Transmembrane TNF-α promotes suppressive activities of myeloid-derived suppressor cells via TNFR2.

Journal of immunology (Baltimore, Md. : 1950)

Hu X,Li B,Li X,Zhao X,Wan L,Lin G,Yu M,Wang J,Jiang X,Feng W,Qin Z,Yin B,Li Z

Sat Feb 01 00:00:00 EST 2014

Inflammasome-dependent and -independent IL-18 production mediates immunity to the ISCOMATRIX adjuvant.

Journal of immunology (Baltimore, Md. : 1950)

Wilson NS,Duewell P,Yang B,Li Y,Marsters S,Koernig S,Latz E,Maraskovsky E,Morelli AB,Schnurr M,Ashkenazi A

Tue Apr 01 00:00:00 EDT 2014

Chemokines as novel and versatile reagents for flow cytometry and cell sorting.

Journal of immunology (Baltimore, Md. : 1950)

Le Brocq ML,Fraser AR,Cotton G,Woznica K,McCulloch CV,Hewitt KD,McKimmie CS,Nibbs RJB,Campbell JDM,Graham GJ

Sun Jun 15 00:00:00 EDT 2014

TNF-α-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma.

Journal of immunology (Baltimore, Md. : 1950)

Uddin MN,Zhang Y,Harton JA,MacNamara KC,Avram D

Sat Feb 15 00:00:00 EST 2014

TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Goto Y,Ogawa K,Nakamura TJ,Hattori A,Tsujimoto M

Thu May 01 00:00:00 EDT 2014

Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes.

Journal of immunology (Baltimore, Md. : 1950)

Dreymueller D,Martin C,Schumacher J,Groth E,Boehm JK,Reiss LK,Uhlig S,Ludwig A

Wed Jan 15 00:00:00 EST 2014

The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Hou Y,Lin H,Zhu L,Liu Z,Hu F,Shi J,Yang T,Shi X,Guo H,Tan X,Zhang L,Wang Q,Li Z,Zhao Y

Tue Jul 01 00:00:00 EDT 2014

MAPK phosphotase 5 deficiency contributes to protection against blood-stage Plasmodium yoelii 17XL infection in mice.

Journal of immunology (Baltimore, Md. : 1950)

Cheng Q,Zhang Q,Xu X,Yin L,Sun L,Lin X,Dong C,Pan W

Tue Apr 15 00:00:00 EDT 2014

IL-13 orchestrates resolution of chronic intestinal inflammation via phosphorylation of glycogen synthase kinase-3β.

Journal of immunology (Baltimore, Md. : 1950)

Fichtner-Feigl S,Kesselring R,Martin M,Obermeier F,Ruemmele P,Kitani A,Brunner SM,Haimerl M,Geissler EK,Strober W,Schlitt HJ

Tue Apr 15 00:00:00 EDT 2014

Autotaxin produced by stromal cells promotes LFA-1-independent and Rho-dependent interstitial T cell motility in the lymph node paracortex.

Journal of immunology (Baltimore, Md. : 1950)

Katakai T,Kondo N,Ueda Y,Kinashi T

Tue Jul 15 00:00:00 EDT 2014

Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux.

Journal of immunology (Baltimore, Md. : 1950)

Franchi L,Eigenbrod T,Muñoz-Planillo R,Ozkurede U,Kim YG,Arindam C,Gale M,Silverman RH,Colonna M,Akira S,Núñez G

Wed Oct 15 00:00:00 EDT 2014

Therapy of peritoneally disseminated colon cancer by TAP-deficient embryonic stem cell-derived macrophages in allogeneic recipients.

Journal of immunology (Baltimore, Md. : 1950)

Haga E,Endo Y,Haruta M,Koba C,Matsumura K,Takamatsu K,Ikeda T,Nishimura Y,Senju S

Fri Aug 15 00:00:00 EDT 2014

A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction.

Journal of cellular and molecular medicine

Chang YL,Chen TH,Wu YH,Chen GA,Weng TH,Tseng PH,Hsieh SL,Fu SL,Lin CH,Chen CJ,Chu CL,Chio II,Mak TW,Chen NJ

Tue Jul 01 00:00:00 EDT 2014

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation.

The Journal of biological chemistry

Kichev A,Rousset CI,Baburamani AA,Levison SW,Wood TL,Gressens P,Thornton C,Hagberg H

Fri Mar 28 00:00:00 EDT 2014

Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy.

Cell death & disease

Grabinger T,Luks L,Kostadinova F,Zimberlin C,Medema JP,Leist M,Brunner T

Thu May 15 00:00:00 EDT 2014

Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy.

Cell death & disease

Grabinger T,Luks L,Kostadinova F,Zimberlin C,Medema JP,Leist M,Brunner T

Thu May 15 00:00:00 EDT 2014

Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation.

Nature communications

Fu H,Kishore M,Gittens B,Wang G,Coe D,Komarowska I,Infante E,Ridley AJ,Cooper D,Perretti M,Marelli-Berg FM

Fri Mar 14 00:00:00 EDT 2014

Opposing TNF-α/IL-1β- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation.

Cell death & disease

Huang RL,Yuan Y,Tu J,Zou GM,Li Q

Thu Apr 17 00:00:00 EDT 2014

Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice.

The Journal of biological chemistry

Ahn BJ,Le H,Shin MW,Bae SJ,Lee EJ,Wee HJ,Cha JH,Lee HJ,Lee HS,Kim JH,Kim CY,Seo JH,Lo EH,Jeon S,Lee MN,Oh GT,Yin GN,Ryu JK,Suh JK,Kim KW

Fri Feb 07 00:00:00 EST 2014

Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung.

The Journal of biological chemistry

McMillan SJ,Sharma RS,Richards HE,Hegde V,Crocker PR

Fri Jul 18 00:00:00 EDT 2014

Ovulation and extra-ovarian origin of ovarian cancer.

Scientific reports

Yang-Hartwich Y,Gurrea-Soteras M,Sumi N,Joo WD,Holmberg JC,Craveiro V,Alvero AB,Mor G

Tue Aug 19 00:00:00 EDT 2014

Tyrosine phosphorylation of Wiskott-Aldrich syndrome protein (WASP) by Hck regulates macrophage function.

The Journal of biological chemistry

Park H,Dovas A,Hanna S,Lastrucci C,Cougoule C,Guiet R,Maridonneau-Parini I,Cox D

Fri Mar 14 00:00:00 EDT 2014

Tumor necrosis factor and transforming growth factor β regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP).

The Journal of biological chemistry

Lopez M,Meier D,Müller A,Franken P,Fujita J,Fontana A

Fri Jan 31 00:00:00 EST 2014

Paneth cells as a site of origin for intestinal inflammation.

Nature

Adolph TE,Tomczak MF,Niederreiter L,Ko HJ,Böck J,Martinez-Naves E,Glickman JN,Tschurtschenthaler M,Hartwig J,Hosomi S,Flak MB,Cusick JL,Kohno K,Iwawaki T,Billmann-Born S,Raine T,Bharti R,Lucius R,Kweon MN,Marciniak SJ,Choi A,Hagen SJ,Schreiber S,Rosenstiel P,Kaser A,Blumberg RS

Thu Nov 14 00:00:00 EST 2013

Tumor necrosis factor-α blocks differentiation and enhances suppressive activity of immature myeloid cells during chronic inflammation.

Immunity

Sade-Feldman M,Kanterman J,Ish-Shalom E,Elnekave M,Horwitz E,Baniyash M

Thu Mar 21 00:00:00 EDT 2013

How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin.

Blood

Vockel M,Vestweber D

Thu Oct 03 00:00:00 EDT 2013

Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses.

The Journal of experimental medicine

Das S,Sarrou E,Podgrabinska S,Cassella M,Mungamuri SK,Feirt N,Gordon R,Nagi CS,Wang Y,Entenberg D,Condeelis J,Skobe M

Mon Jul 29 00:00:00 EDT 2013

Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Masuda K,Ripley B,Nishimura R,Mino T,Takeuchi O,Shioi G,Kiyonari H,Kishimoto T

Tue Jun 04 00:00:00 EDT 2013

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury.

Proceedings of the National Academy of Sciences of the United States of America

Linkermann A,Bräsen JH,Darding M,Jin MK,Sanz AB,Heller JO,De Zen F,Weinlich R,Ortiz A,Walczak H,Weinberg JM,Green DR,Kunzendorf U,Krautwald S

Tue Jul 16 00:00:00 EDT 2013

Mesenchymal stem cells are mobilized from the bone marrow during inflammation.

Frontiers in immunology

Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE

Wed Mar 06 00:00:00 EST 2013

Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs.

The Journal of cell biology

Liou GY,Döppler H,Necela B,Krishna M,Crawford HC,Raimondo M,Storz P

Mon Aug 05 00:00:00 EDT 2013

TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.

Journal of immunology (Baltimore, Md. : 1950)

Chen X,Wu X,Zhou Q,Howard OM,Netea MG,Oppenheim JJ

Fri Feb 01 00:00:00 EST 2013

Adam8 limits the development of allergic airway inflammation in mice.

Journal of immunology (Baltimore, Md. : 1950)

Knolle MD,Nakajima T,Hergrueter A,Gupta K,Polverino F,Craig VJ,Fyfe SE,Zahid M,Permaul P,Cernadas M,Montano G,Tesfaigzi Y,Sholl L,Kobzik L,Israel E,Owen CA

Sat Jun 15 00:00:00 EDT 2013

Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Edwards JP,Fujii H,Zhou AX,Creemers J,Unutmaz D,Shevach EM

Sat Jun 01 00:00:00 EDT 2013

Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.

Journal of immunology (Baltimore, Md. : 1950)

Liu B,Wang M,Wang X,Zhao D,Liu D,Liu J,Chen PJ,Yang D,He F,Tang L

Mon Apr 15 00:00:00 EDT 2013

Retinoid X receptor agonists modulate Foxp3⁺ regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation.

Journal of immunology (Baltimore, Md. : 1950)

Takeuchi H,Yokota-Nakatsuma A,Ohoka Y,Kagechika H,Kato C,Song SY,Iwata M

Tue Oct 01 00:00:00 EDT 2013

Tumor-derived vascular pericytes anergize Th cells.

Journal of immunology (Baltimore, Md. : 1950)

Bose A,Barik S,Banerjee S,Ghosh T,Mallick A,Bhattacharyya Majumdar S,Goswami KK,Bhuniya A,Banerjee S,Baral R,Storkus WJ,Dasgupta PS,Majumdar S

Mon Jul 15 00:00:00 EDT 2013

Inflammation-mediated notch signaling skews fanconi anemia hematopoietic stem cell differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Du W,Amarachintha S,Sipple J,Schick J,Steinbrecher K,Pang Q

Sun Sep 01 00:00:00 EDT 2013

Inflammatory cytokine-mediated evasion of virus-induced tumors from NK cell control.

Journal of immunology (Baltimore, Md. : 1950)

Mishra R,Polic B,Welsh RM,Szomolanyi-Tsuda E

Mon Jul 15 00:00:00 EDT 2013

Wnt6 is expressed in granulomatous lesions of Mycobacterium tuberculosis-infected mice and is involved in macrophage differentiation and proliferation.

Journal of immunology (Baltimore, Md. : 1950)

Schaale K,Brandenburg J,Kispert A,Leitges M,Ehlers S,Reiling N

Fri Nov 15 00:00:00 EST 2013

Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Antonopoulos C,El Sanadi C,Kaiser WJ,Mocarski ES,Dubyak GR

Fri Nov 01 00:00:00 EDT 2013

Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis.

Journal of immunology (Baltimore, Md. : 1950)

Hou L,Jie Z,Desai M,Liang Y,Soong L,Wang T,Sun J

Tue Jan 15 00:00:00 EST 2013

TLR3, TRIF, and caspase 8 determine double-stranded RNA-induced epithelial cell death and survival in vivo.

Journal of immunology (Baltimore, Md. : 1950)

McAllister CS,Lakhdari O,Pineton de Chambrun G,Gareau MG,Broquet A,Lee GH,Shenouda S,Eckmann L,Kagnoff MF

Tue Jan 01 00:00:00 EST 2013

Suprachiasmatic astrocytes modulate the circadian clock in response to TNF-α.

Journal of immunology (Baltimore, Md. : 1950)

Duhart JM,Leone MJ,Paladino N,Evans JA,Castanon-Cervantes O,Davidson AJ,Golombek DA

Fri Nov 01 00:00:00 EDT 2013

Adhesion to substrates induces dendritic cell endothelization and decreases immunological response.

Immunobiology

Osterbur J,Sprague L,Muccioli M,Pate M,Mansfield K,McGinty J,Li Y,Li Y,Shirure V,Courreges MC,Benencia F

315-01A was used in Cell Culture to investigate the effects of different soluble factors, substrates and culture surfaces on the phenotype and function of dendritic cells.

Tue Jan 01 00:00:00 EST 2013

Lactosylceramide interacts with and activates cytosolic phospholipase A2α.

The Journal of biological chemistry

Nakamura H,Moriyama Y,Makiyama T,Emori S,Yamashita H,Yamazaki R,Murayama T

Fri Aug 09 00:00:00 EDT 2013

Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

The Journal of biological chemistry

Kaiser WJ,Sridharan H,Huang C,Mandal P,Upton JW,Gough PJ,Sehon CA,Marquis RW,Bertin J,Mocarski ES

Fri Oct 25 00:00:00 EDT 2013

Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages.

The Journal of biological chemistry

Rubinow KB,Wall VZ,Nelson J,Mar D,Bomsztyk K,Askari B,Lai MA,Smith KD,Han MS,Vivekanandan-Giri A,Pennathur S,Albert CJ,Ford DA,Davis RJ,Bornfeldt KE

Fri Apr 05 00:00:00 EDT 2013

Ezrin and moesin are required for efficient T cell adhesion and homing to lymphoid organs.

PloS one

Chen EJ,Shaffer MH,Williamson EK,Huang Y,Burkhardt JK

Fri Aug 23 00:00:00 EDT 2013

The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor-β (TGFβ) signaling.

The Journal of biological chemistry

Du B,Cawthorn WP,Su A,Doucette CR,Yao Y,Hemati N,Kampert S,McCoin C,Broome DT,Rosen CJ,Yang G,MacDougald OA

Fri Feb 01 00:00:00 EST 2013

A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.

PloS one

Ucero AC,Berzal S,Ocaña-Salceda C,Sancho M,Orzáez M,Messeguer A,Ruiz-Ortega M,Egido J,Vicent MJ,Ortiz A,Ramos AM

Tue Aug 20 00:00:00 EDT 2013

Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation.

The Journal of biological chemistry

Adada MM,Orr-Gandy KA,Snider AJ,Canals D,Hannun YA,Obeid LM,Clarke CJ

Fri Sep 20 00:00:00 EDT 2013

Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2.

Journal of translational medicine

Przybyt E,Krenning G,Brinker MG,Harmsen MC

Wed Feb 13 00:00:00 EST 2013

Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2.

Journal of translational medicine

Przybyt E,Krenning G,Brinker MG,Harmsen MC

Wed Feb 13 00:00:00 EST 2013

Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2.

Journal of translational medicine

Przybyt E,Krenning G,Brinker MG,Harmsen MC

Wed Feb 13 00:00:00 EST 2013

Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expression.

The Journal of biological chemistry

Chandra A,Lan S,Zhu J,Siclari VA,Qin L

Fri Jul 12 00:00:00 EDT 2013

Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.

The Journal of biological chemistry

Sanz-Garcia C,Ferrer-Mayorga G,González-Rodríguez Á,Valverde AM,Martín-Duce A,Velasco-Martín JP,Regadera J,Fernández M,Alemany S

Fri May 24 00:00:00 EDT 2013

Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis.

PloS one

Nisticò R,Mango D,Mandolesi G,Piccinin S,Berretta N,Pignatelli M,Feligioni M,Musella A,Gentile A,Mori F,Bernardi G,Nicoletti F,Mercuri NB,Centonze D

Mon Jun 24 00:00:00 EDT 2013

Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.

PloS one

McNamara CR,Ahuja R,Osafo-Addo AD,Barrows D,Kettenbach A,Skidan I,Teng X,Cuny GD,Gerber S,Degterev A

Tue Aug 27 00:00:00 EDT 2013

Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.

Cell

Spann NJ,Garmire LX,McDonald JG,Myers DS,Milne SB,Shibata N,Reichart D,Fox JN,Shaked I,Heudobler D,Raetz CR,Wang EW,Kelly SL,Sullards MC,Murphy RC,Merrill AH,Brown HA,Dennis EA,Li AC,Ley K,Tsimikas S,Fahy E,Subramaniam S,Quehenberger O,Russell DW,Glass CK

Fri Sep 28 00:00:00 EDT 2012

Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein.

Immunity

Nakamura Y,Franchi L,Kambe N,Meng G,Strober W,Núñez G

Fri Jul 27 00:00:00 EDT 2012

A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.

Immunity

Yamamoto M,Okuyama M,Ma JS,Kimura T,Kamiyama N,Saiga H,Ohshima J,Sasai M,Kayama H,Okamoto T,Huang DC,Soldati-Favre D,Horie K,Takeda J,Takeda K

Fri Aug 24 00:00:00 EDT 2012

Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression.

Blood

Adhikary S,Kocieda VP,Yen JH,Tuma RF,Ganea D

Thu Nov 01 00:00:00 EDT 2012

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.

Blood

Fortes GB,Alves LS,de Oliveira R,Dutra FF,Rodrigues D,Fernandez PL,Souto-Padron T,De Rosa MJ,Kelliher M,Golenbock D,Chan FK,Bozza MT

Thu Mar 08 00:00:00 EST 2012

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.

Blood

Lefort CT,Rossaint J,Moser M,Petrich BG,Zarbock A,Monkley SJ,Critchley DR,Ginsberg MH,Fässler R,Ley K

Thu May 03 00:00:00 EDT 2012

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.

Blood

Everts B,Amiel E,van der Windt GJ,Freitas TC,Chott R,Yarasheski KE,Pearce EL,Pearce EJ

Thu Aug 16 00:00:00 EDT 2012

Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.

Blood

Pulvino M,Liang Y,Oleksyn D,DeRan M,Van Pelt E,Shapiro J,Sanz I,Chen L,Zhao J

Thu Aug 23 00:00:00 EDT 2012

TNF signaling drives myeloid-derived suppressor cell accumulation.

The Journal of clinical investigation

Zhao X,Rong L,Zhao X,Li X,Liu X,Deng J,Wu H,Xu X,Erben U,Wu P,Syrbe U,Sieper J,Qin Z

Thu Nov 01 00:00:00 EDT 2012

Epidermal growth factor receptor inhibits colitis-associated cancer in mice.

The Journal of clinical investigation

Dubé PE,Yan F,Punit S,Girish N,McElroy SJ,Washington MK,Polk DB

Wed Aug 01 00:00:00 EDT 2012

Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.

The Journal of clinical investigation

Yiakouvaki A,Dimitriou M,Karakasiliotis I,Eftychi C,Theocharis S,Kontoyiannis DL

Sun Jan 01 00:00:00 EST 2012

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.

The Journal of experimental medicine

Zhao B,Grimes SN,Li S,Hu X,Ivashkiv LB

Mon Feb 13 00:00:00 EST 2012

High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.

The Journal of experimental medicine

Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ

Mon Jan 16 00:00:00 EST 2012

B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K.

Proceedings of the National Academy of Sciences of the United States of America

Ni M,MacFarlane AW,Toft M,Lowell CA,Campbell KS,Hamerman JA

Tue Jan 03 00:00:00 EST 2012

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Stolp B,Imle A,Coelho FM,Hons M,Gorina R,Lyck R,Stein JV,Fackler OT

Tue Nov 06 00:00:00 EST 2012

Dynamic migration of γδ intraepithelial lymphocytes requires occludin.

Proceedings of the National Academy of Sciences of the United States of America

Edelblum KL,Shen L,Weber CR,Marchiando AM,Clay BS,Wang Y,Prinz I,Malissen B,Sperling AI,Turner JR

Tue May 01 00:00:00 EDT 2012

L-selectin and SDF-1 enhance the migration of mouse and human cardiac mesoangioblasts.

Cell death and differentiation

Bernal A,San Martín N,Fernández M,Covarello D,Molla F,Soldo A,Latini R,Cossu G,Gálvez BG

Wed Feb 01 00:00:00 EST 2012

Effective adoptive transfer of haploidentical tumor-specific T cells in B16-melanoma bearing mice.

Chinese medical journal

Cui NP,Xie SJ,Han JS,Ma ZF,Chen BP,Cai JH

Thu Mar 01 00:00:00 EST 2012

Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Schiffmann S,Ferreiros N,Birod K,Eberle M,Schreiber Y,Pfeilschifter W,Ziemann U,Pierre S,Scholich K,Grösch S,Geisslinger G

Fri Jun 01 00:00:00 EDT 2012

Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions.

Journal of immunology (Baltimore, Md. : 1950)

Bian Z,Guo Y,Ha B,Zen K,Liu Y

Sun Jan 15 00:00:00 EST 2012

CIKS/Act1-mediated signaling by IL-17 cytokines in context: implications for how a CIKS gene variant may predispose to psoriasis.

Journal of immunology (Baltimore, Md. : 1950)

Sønder SU,Paun A,Ha HL,Johnson PF,Siebenlist U

Fri Jun 15 00:00:00 EDT 2012

The HGF receptor/Met tyrosine kinase is a key regulator of dendritic cell migration in skin immunity.

Journal of immunology (Baltimore, Md. : 1950)

Baek JH,Birchmeier C,Zenke M,Hieronymus T

Wed Aug 15 00:00:00 EDT 2012

Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms.

Journal of immunology (Baltimore, Md. : 1950)

Poovassery JS,Bishop GA

Wed Aug 15 00:00:00 EDT 2012

Difference in Th1 and Th17 lymphocyte adhesion to endothelium.

Journal of immunology (Baltimore, Md. : 1950)

Alcaide P,Maganto-Garcia E,Newton G,Travers R,Croce KJ,Bu DX,Luscinskas FW,Lichtman AH

Wed Feb 01 00:00:00 EST 2012

Difference in Th1 and Th17 lymphocyte adhesion to endothelium.

Journal of immunology (Baltimore, Md. : 1950)

Alcaide P,Maganto-Garcia E,Newton G,Travers R,Croce KJ,Bu DX,Luscinskas FW,Lichtman AH

Wed Feb 01 00:00:00 EST 2012

Metabolic characterization of Leishmania major infection in activated and nonactivated macrophages.

Journal of proteome research

Lamour SD,Choi BS,Keun HC,Müller I,Saric J

Fri Aug 03 00:00:00 EDT 2012

NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages.

The Journal of biological chemistry

Ejlerskov P,Christensen DP,Beyaie D,Burritt JB,Paclet MH,Gorlach A,van Deurs B,Vilhardt F

Fri Feb 10 00:00:00 EST 2012

Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo.

The Journal of biological chemistry

Bernard JK,McCann SP,Bhardwaj V,Washington MK,Frey MR

Fri Nov 16 00:00:00 EST 2012

Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo.

The Journal of biological chemistry

Bernard JK,McCann SP,Bhardwaj V,Washington MK,Frey MR

Fri Nov 16 00:00:00 EST 2012

Stromal adipocyte enhancer-binding protein (AEBP1) promotes mammary epithelial cell hyperplasia via proinflammatory and hedgehog signaling.

The Journal of biological chemistry

Holloway RW,Bogachev O,Bharadwaj AG,McCluskey GD,Majdalawieh AF,Zhang L,Ro HS

Fri Nov 09 00:00:00 EST 2012

TNF-α is involved in the abnormal thymocyte migration during experimental Trypanosoma cruzi infection and favors the export of immature cells.

PloS one

Pérez AR,Berbert LR,Lepletier A,Revelli S,Bottasso O,Silva-Barbosa SD,Savino W

Fri Jun 29 00:00:00 EDT 2012

Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.

The Journal of biological chemistry

Kensche T,Tokunaga F,Ikeda F,Goto E,Iwai K,Dikic I

Fri Jul 06 00:00:00 EDT 2012

Severe thymic atrophy in a mouse model of skin inflammation accounts for impaired TNFR1 signaling.

PloS one

Belhacéne N,Gamas P,Gonçalvès D,Jacquin M,Beneteau M,Jacquel A,Colosetti P,Ricci JE,Wakkach A,Auberger P,Marchetti S

Fri Feb 22 00:00:00 EST 2013

Expression and secretion of TNF-α in mouse taste buds: a novel function of a specific subset of type II taste cells.

PloS one

Feng P,Zhao H,Chai J,Huang L,Wang H

Mon Feb 11 00:00:00 EST 2013

Comparison of the virulence potential of Acinetobacter strains from clinical and environmental sources.

PloS one

Tayabali AF,Nguyen KC,Shwed PS,Crosthwait J,Coleman G,Seligy VL

Thu Sep 27 00:00:00 EDT 2012

Comparison of the virulence potential of Acinetobacter strains from clinical and environmental sources.

PloS one

Tayabali AF,Nguyen KC,Shwed PS,Crosthwait J,Coleman G,Seligy VL

Thu Sep 27 00:00:00 EDT 2012

Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism.

PloS one

Corridoni D,Pastorelli L,Mattioli B,Locovei S,Ishikawa D,Arseneau KO,Chieppa M,Cominelli F,Pizarro TT

Thu Jan 10 00:00:00 EST 2013

Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism.

PloS one

Corridoni D,Pastorelli L,Mattioli B,Locovei S,Ishikawa D,Arseneau KO,Chieppa M,Cominelli F,Pizarro TT

Thu Jan 10 00:00:00 EST 2013

Exposure of a distinct PDCA-1+ (CD317) B cell population to agonistic anti-4-1BB (CD137) inhibits T and B cell responses both in vitro and in vivo.

PloS one

Vinay DS,Lee SJ,Kim CH,Oh HS,Kwon BS

Mon May 13 00:00:00 EDT 2013

The microRNA miR-181c controls microglia-mediated neuronal apoptosis by suppressing tumor necrosis factor.

Journal of neuroinflammation

Zhang L,Dong LY,Li YJ,Hong Z,Wei WS

Thu Sep 06 00:00:00 EDT 2012

Prostaglandin E2-induced IL-23p19 subunit is regulated by cAMP-responsive element-binding protein and C/AATT enhancer-binding protein β in bone marrow-derived dendritic cells.

The Journal of biological chemistry

Kocieda VP,Adhikary S,Emig F,Yen JH,Toscano MG,Ganea D

Fri Oct 26 00:00:00 EDT 2012

Non-apoptotic role of BID in inflammation and innate immunity.

Nature

Yeretssian G,Correa RG,Doiron K,Fitzgerald P,Dillon CP,Green DR,Reed JC,Saleh M

Thu Jun 02 00:00:00 EDT 2011

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity.

Nature

Sander LE,Davis MJ,Boekschoten MV,Amsen D,Dascher CC,Ryffel B,Swanson JA,Müller M,Blander JM

Sun May 22 00:00:00 EDT 2011

Lymph node T cell homeostasis relies on steady state homing of dendritic cells.

Immunity

Wendland M,Willenzon S,Kocks J,Davalos-Misslitz AC,Hammerschmidt SI,Schumann K,Kremmer E,Sixt M,Hoffmeyer A,Pabst O,Förster R

Fri Dec 23 00:00:00 EST 2011

Langerhans cells are not required for graft-versus-host disease.

Blood

Li H,Kaplan DH,Matte-Martone C,Tan HS,Venkatesan S,Johnson K,Demetris AJ,McNiff J,Shlomchik MJ,Shlomchik WD

Thu Jan 13 00:00:00 EST 2011

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice.

The Journal of clinical investigation

Sindrilaru A,Peters T,Wieschalka S,Baican C,Baican A,Peter H,Hainzl A,Schatz S,Qi Y,Schlecht A,Weiss JM,Wlaschek M,Sunderkötter C,Scharffetter-Kochanek K

Tue Mar 01 00:00:00 EST 2011

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.

The Journal of clinical investigation

Lerner I,Hermano E,Zcharia E,Rodkin D,Bulvik R,Doviner V,Rubinstein AM,Ishai-Michaeli R,Atzmon R,Sherman Y,Meirovitz A,Peretz T,Vlodavsky I,Elkin M

Sun May 01 00:00:00 EDT 2011

CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice.

The Journal of clinical investigation

Wang L,Fan J,Thompson LF,Zhang Y,Shin T,Curiel TJ,Zhang B

Wed Jun 01 00:00:00 EDT 2011

Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo.

The Journal of experimental medicine

Schnoor M,Lai FP,Zarbock A,Kläver R,Polaschegg C,Schulte D,Weich HA,Oelkers JM,Rottner K,Vestweber D

Mon Aug 01 00:00:00 EDT 2011

Murine gamma herpesvirus 68 hijacks MAVS and IKKβ to abrogate NFκB activation and antiviral cytokine production.

PLoS pathogens

Dong X,Feng P

Tue Nov 01 00:00:00 EDT 2011

Murine gamma herpesvirus 68 hijacks MAVS and IKKβ to abrogate NFκB activation and antiviral cytokine production.

PLoS pathogens

Dong X,Feng P

Tue Nov 01 00:00:00 EDT 2011

Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria.

Journal of immunology (Baltimore, Md. : 1950)

Doisne JM,Soulard V,Bécourt C,Amniai L,Henrot P,Havenar-Daughton C,Blanchet C,Zitvogel L,Ryffel B,Cavaillon JM,Marie JC,Couillin I,Benlagha K

Sat Jan 15 00:00:00 EST 2011

IL-21-dependent B cell death driven by prostaglandin E2, a product secreted from follicular dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Magari M,Nishikawa Y,Fujii Y,Nishio Y,Watanabe K,Fujiwara M,Kanayama N,Ohmori H

Sat Oct 15 00:00:00 EDT 2011

Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Wang L,Du C,Lv J,Wei W,Cui Y,Xie X

Thu Sep 01 00:00:00 EDT 2011

The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia.

Journal of immunology (Baltimore, Md. : 1950)

Möser CV,Kynast K,Baatz K,Russe OQ,Ferreirós N,Costiuk H,Lu R,Schmidtko A,Tegeder I,Geisslinger G,Niederberger E

Thu Sep 01 00:00:00 EDT 2011

Dendritic cells distinguish individual chemokine signals through CCR7 and CXCR4.

Journal of immunology (Baltimore, Md. : 1950)

Ricart BG,John B,Lee D,Hunter CA,Hammer DA

Sat Jan 01 00:00:00 EST 2011

Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis.

Clinical & experimental metastasis

Seike T,Fujita K,Yamakawa Y,Kido MA,Takiguchi S,Teramoto N,Iguchi H,Noda M

Sat Jan 01 00:00:00 EST 2011

Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis.

Clinical & experimental metastasis

Seike T,Fujita K,Yamakawa Y,Kido MA,Takiguchi S,Teramoto N,Iguchi H,Noda M

Sat Jan 01 00:00:00 EST 2011

Influence of synthetic superparamagnetic iron oxide on dendritic cells.

International journal of nanomedicine

Mou Y,Chen B,Zhang Y,Hou Y,Xie H,Xia G,Tang M,Huang X,Ni Y,Hu Q

Wed Feb 08 00:00:00 EST 2012

Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma.

The Journal of biological chemistry

Goto Y,Ogawa K,Hattori A,Tsujimoto M

Fri Jun 17 00:00:00 EDT 2011

Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.

PloS one

Takeuchi H,Yokota A,Ohoka Y,Iwata M

Fri Jan 07 00:00:00 EST 2011

Co-administration of IL-1+IL-6+TNF-α with Mycobacterium tuberculosis infected macrophages vaccine induces better protective T cell memory than BCG.

PloS one

Singh V,Jain S,Gowthaman U,Parihar P,Gupta P,Gupta UD,Agrewala JN

Wed Jan 19 00:00:00 EST 2011

IL-17-induced NF-kappaB activation via CIKS/Act1: physiologic significance and signaling mechanisms.

The Journal of biological chemistry

Sønder SU,Saret S,Tang W,Sturdevant DE,Porcella SF,Siebenlist U

Fri Apr 15 00:00:00 EDT 2011

In vivo migration of dendritic cells labeled with synthetic superparamagnetic iron oxide.

International journal of nanomedicine

Mou Y,Hou Y,Chen B,Hua Z,Zhang Y,Xie H,Xia G,Wang Z,Huang X,Han W,Ni Y,Hu Q

Tue Mar 27 00:00:00 EDT 2012

In vivo migration of dendritic cells labeled with synthetic superparamagnetic iron oxide.

International journal of nanomedicine

Mou Y,Hou Y,Chen B,Hua Z,Zhang Y,Xie H,Xia G,Wang Z,Huang X,Han W,Ni Y,Hu Q

Tue Mar 27 00:00:00 EDT 2012

Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.

PloS one

Haas JD,Nistala K,Petermann F,Saran N,Chennupati V,Schmitz S,Korn T,Wedderburn LR,Förster R,Krueger A,Prinz I

Thu Sep 29 00:00:00 EDT 2011

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8.

The Journal of biological chemistry

Gentle IE,Wong WW,Evans JM,Bankovacki A,Cook WD,Khan NR,Nachbur U,Rickard J,Anderton H,Moulin M,Lluis JM,Moujalled DM,Silke J,Vaux DL

Fri Apr 15 00:00:00 EDT 2011

Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer.

The Journal of biological chemistry

Liu Y,Han ZP,Zhang SS,Jing YY,Bu XX,Wang CY,Sun K,Jiang GC,Zhao X,Li R,Gao L,Zhao QD,Wu MC,Wei LX

Fri Jul 15 00:00:00 EDT 2011

Early effects of lipopolysaccharide-induced inflammation on foetal brain development in rat.

ASN neuro

Ghiani CA,Mattan NS,Nobuta H,Malvar JS,Boles J,Ross MG,Waschek JA,Carpenter EM,Fisher RS,de Vellis J

Thu Nov 17 00:00:00 EST 2011

The non-phagocytic route of collagen uptake: a distinct degradation pathway.

The Journal of biological chemistry

Madsen DH,Ingvarsen S,Jürgensen HJ,Melander MC,Kjøller L,Moyer A,Honoré C,Madsen CA,Garred P,Burgdorf S,Bugge TH,Behrendt N,Engelholm LH

Fri Jul 29 00:00:00 EDT 2011

Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.

PloS one

Krajewska M,You Z,Rong J,Kress C,Huang X,Yang J,Kyoda T,Leyva R,Banares S,Hu Y,Sze CH,Whalen MJ,Salmena L,Hakem R,Head BP,Reed JC,Krajewski S

Fri Feb 03 00:00:00 EST 2012

Recruitment of RelB to the Csf2 promoter enhances RelA-mediated transcription of granulocyte-macrophage colony-stimulating factor.

The Journal of biological chemistry

Sasaki CY,Ghosh P,Longo DL

Fri Jan 14 00:00:00 EST 2011

Mesenchymal stem cells exhibit firm adhesion, crawling, spreading and transmigration across aortic endothelial cells: effects of chemokines and shear.

PloS one

Chamberlain G,Smith H,Rainger GE,Middleton J

Thu Jan 26 00:00:00 EST 2012

MHC mismatch inhibits neurogenesis and neuron maturation in stem cell allografts.

PloS one

Chen Z,Phillips LK,Gould E,Campisi J,Lee SW,Ormerod BK,Zwierzchoniewska M,Martinez OM,Palmer TD

Wed Mar 30 00:00:00 EDT 2011

Generation and labeling of murine bone marrow-derived dendritic cells with Qdot nanocrystals for tracking studies.

Journal of visualized experiments : JoVE

Muccioli M,Pate M,Omosebi O,Benencia F

Thu Jun 02 00:00:00 EDT 2011

The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells.

BMC immunology

Sprague L,Muccioli M,Pate M,Meles E,McGinty J,Nandigam H,Venkatesh AK,Gu MY,Mansfield K,Rutowski A,Omosebi O,Courreges MC,Benencia F

Mon Jun 06 00:00:00 EDT 2011

The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells.

BMC immunology

Sprague L,Muccioli M,Pate M,Meles E,McGinty J,Nandigam H,Venkatesh AK,Gu MY,Mansfield K,Rutowski A,Omosebi O,Courreges MC,Benencia F

Mon Jun 06 00:00:00 EDT 2011

Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.

PloS one

Siegert S,Huang HY,Yang CY,Scarpellino L,Carrie L,Essex S,Nelson PJ,Heikenwalder M,Acha-Orbea H,Buckley CD,Marsland BJ,Zehn D,Luther SA

Mon Mar 26 00:00:00 EDT 2012

Deletion of the aryl hydrocarbon receptor enhances the inflammatory response to Leishmania major infection.

International journal of biological sciences

Elizondo G,Rodríguez-Sosa M,Estrada-Muñiz E,Gonzalez FJ,Vega L

Tue May 29 00:00:00 EDT 2012

STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.

Immunity

Szanto A,Balint BL,Nagy ZS,Barta E,Dezso B,Pap A,Szeles L,Poliska S,Oros M,Evans RM,Barak Y,Schwabe J,Nagy L

Wed Nov 24 00:00:00 EST 2010

Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice.

The Journal of clinical investigation

Kovacic JC,Gupta R,Lee AC,Ma M,Fang F,Tolbert CN,Walts AD,Beltran LE,San H,Chen G,St Hilaire C,Boehm M

Fri Jan 01 00:00:00 EST 2010

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function.

The Journal of experimental medicine

Sander LE,Sackett SD,Dierssen U,Beraza N,Linke RP,Müller M,Blander JM,Tacke F,Trautwein C

Mon Jul 05 00:00:00 EDT 2010

Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile.

The Journal of experimental medicine

Lutgens E,Lievens D,Beckers L,Wijnands E,Soehnlein O,Zernecke A,Seijkens T,Engel D,Cleutjens J,Keller AM,Naik SH,Boon L,Oufella HA,Mallat Z,Ahonen CL,Noelle RJ,de Winther MP,Daemen MJ,Biessen EA,Weber C

Mon Feb 15 00:00:00 EST 2010

Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.

The Journal of experimental medicine

Scapini P,Hu Y,Chu CL,Migone TS,Defranco AL,Cassatella MA,Lowell CA

Mon Aug 02 00:00:00 EDT 2010

Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Carbajal KS,Schaumburg C,Strieter R,Kane J,Lane TE

Tue Jun 15 00:00:00 EDT 2010

Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth.

Oncogene

Cantelmo AR,Cammarota R,Noonan DM,Focaccetti C,Comoglio PM,Prat M,Albini A

Thu Sep 23 00:00:00 EDT 2010

Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo.

The Journal of cell biology

Marchiando AM,Shen L,Graham WV,Weber CR,Schwarz BT,Austin JR,Raleigh DR,Guan Y,Watson AJ,Montrose MH,Turner JR

Mon Apr 05 00:00:00 EDT 2010

Injury is a major inducer of epidermal innate immune responses during wound healing.

The Journal of investigative dermatology

Roupé KM,Nybo M,Sjöbring U,Alberius P,Schmidtchen A,Sørensen OE

Thu Apr 01 00:00:00 EDT 2010

Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine.

Journal of immunology (Baltimore, Md. : 1950)

Wang C,Kang SG,HogenEsch H,Love PE,Kim CH

Sat May 15 00:00:00 EDT 2010

Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice.

Journal of immunology (Baltimore, Md. : 1950)

Németh T,Futosi K,Hably C,Brouns MR,Jakob SM,Kovács M,Kertész Z,Walzog B,Settleman J,Mócsai A

Wed Sep 01 00:00:00 EDT 2010

The interactions of multiple cytokines control NK cell maturation.

Journal of immunology (Baltimore, Md. : 1950)

Brady J,Carotta S,Thong RP,Chan CJ,Hayakawa Y,Smyth MJ,Nutt SL

Wed Dec 01 00:00:00 EST 2010

Crucial role of phospholipase Cepsilon in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity.

Journal of immunology (Baltimore, Md. : 1950)

Hu L,Edamatsu H,Takenaka N,Ikuta S,Kataoka T

Fri Jan 15 00:00:00 EST 2010

Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration.

Journal of immunology (Baltimore, Md. : 1950)

König K,Diehl L,Rommerscheidt-Fuss U,Golletz C,Quast T,Kahl P,Kolanus W,Knolle P,Buettner R,Heukamp LC

Sun Aug 01 00:00:00 EDT 2010

The origin and maturity of dendritic cells determine the pattern of sphingosine 1-phosphate receptors expressed and required for efficient migration.

Journal of immunology (Baltimore, Md. : 1950)

Rathinasamy A,Czeloth N,Pabst O,Förster R,Bernhardt G

Fri Oct 01 00:00:00 EDT 2010

An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Suchard SJ,Stetsko DK,Davis PM,Skala S,Potin D,Launay M,Dhar TG,Barrish JC,Susulic V,Shuster DJ,McIntyre KW,McKinnon M,Salter-Cid L

Thu Apr 01 00:00:00 EDT 2010

IFN-beta inhibits dendritic cell migration through STAT-1-mediated transcriptional suppression of CCR7 and matrix metalloproteinase 9.

Journal of immunology (Baltimore, Md. : 1950)

Yen JH,Kong W,Ganea D

Thu Apr 01 00:00:00 EDT 2010

Ischemic injury enhances dendritic cell immunogenicity via TLR4 and NF-kappa B activation.

Journal of immunology (Baltimore, Md. : 1950)

Jurewicz M,Takakura A,Augello A,Movahedi Naini S,Ichimura T,Zandi-Nejad K,Abdi R

Mon Mar 15 00:00:00 EDT 2010

Peroxynitrite-dependent killing of cancer cells and presentation of released tumor antigens by activated dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Fraszczak J,Trad M,Janikashvili N,Cathelin D,Lakomy D,Granci V,Morizot A,Audia S,Micheau O,Lagrost L,Katsanis E,Solary E,Larmonier N,Bonnotte B

Mon Feb 15 00:00:00 EST 2010

B1 cells promote pancreas infiltration by autoreactive T cells.

Journal of immunology (Baltimore, Md. : 1950)

Ryan GA,Wang CJ,Chamberlain JL,Attridge K,Schmidt EM,Kenefeck R,Clough LE,Dunussi-Joannopoulos K,Toellner KM,Walker LS

Wed Sep 01 00:00:00 EDT 2010

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.

Cellular microbiology

Khaminets A,Hunn JP,Könen-Waisman S,Zhao YO,Preukschat D,Coers J,Boyle JP,Ong YC,Boothroyd JC,Reichmann G,Howard JC

Thu Jul 01 00:00:00 EDT 2010

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.

Cellular microbiology

Khaminets A,Hunn JP,Könen-Waisman S,Zhao YO,Preukschat D,Coers J,Boyle JP,Ong YC,Boothroyd JC,Reichmann G,Howard JC

Thu Jul 01 00:00:00 EDT 2010

The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels.

PloS one

Portillo JA,Okenka G,Reed E,Subauste A,Van Grol J,Gentil K,Komatsu M,Tanaka K,Landreth G,Levine B,Subauste CS

Fri Dec 31 00:00:00 EST 2010

Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells.

BMC neuroscience

Cohn ZJ,Kim A,Huang L,Brand J,Wang H

Thu Jun 10 00:00:00 EDT 2010

N-type calcium channel in the pathogenesis of experimental autoimmune encephalomyelitis.

The Journal of biological chemistry

Tokuhara N,Namiki K,Uesugi M,Miyamoto C,Ohgoh M,Ido K,Yoshinaga T,Yamauchi T,Kuromitsu J,Kimura S,Miyamoto N,Kasuya Y

Fri Oct 22 00:00:00 EDT 2010

Thy-1 attenuates TNF-alpha-activated gene expression in mouse embryonic fibroblasts via Src family kinase.

PloS one

Shan B,Hagood JS,Zhuo Y,Nguyen HT,MacEwen M,Morris GF,Lasky JA

Mon Jul 19 00:00:00 EDT 2010

Docosahexaenoic acid prevents dendritic cell maturation and in vitro and in vivo expression of the IL-12 cytokine family.

Lipids in health and disease

Kong W,Yen JH,Vassiliou E,Adhikary S,Toscano MG,Ganea D

Mon Feb 01 00:00:00 EST 2010

Phospholipase D1 mediates TNFalpha-induced inflammation in a murine model of TNFalpha-induced peritonitis.

PloS one

Sethu S,Pushparaj PN,Melendez AJ

Wed May 05 00:00:00 EDT 2010

B7-H1-deficiency enhances the potential of tolerogenic dendritic cells by activating CD1d-restricted type II NKT cells.

PloS one

Brandl C,Ortler S,Herrmann T,Cardell S,Lutz MB,Wiendl H

Mon May 24 00:00:00 EDT 2010

Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia.

PloS one

Baron RM,Lopez-Guzman S,Riascos DF,Macias AA,Layne MD,Cheng G,Harris C,Chung SW,Reeves R,von Andrian UH,Perrella MA

Fri May 14 00:00:00 EDT 2010

Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis.

The Journal of biological chemistry

Park J,Kang SI,Lee SY,Zhang XF,Kim MS,Beers LF,Lim DS,Avruch J,Kim HS,Lee SB

Fri Nov 05 00:00:00 EDT 2010

PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification.

The Journal of biological chemistry

Tseng W,Graham LS,Geng Y,Reddy A,Lu J,Effros RB,Demer L,Tintut Y

Fri Sep 24 00:00:00 EDT 2010

Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblasts.

The Journal of biological chemistry

Majewski PM,Thurston RD,Ramalingam R,Kiela PR,Ghishan FK

Fri Nov 05 00:00:00 EDT 2010

S-nitrosylation regulates nuclear translocation of chloride intracellular channel protein CLIC4.

The Journal of biological chemistry

Malik M,Shukla A,Amin P,Niedelman W,Lee J,Jividen K,Phang JM,Ding J,Suh KS,Curmi PM,Yuspa SH

Fri Jul 30 00:00:00 EDT 2010

Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1).

The Journal of biological chemistry

Kaieda S,Shin K,Nigrovic PA,Seki K,Lee RT,Stevens RL,Lee DM

Fri Jul 09 00:00:00 EDT 2010

Central control of fever and female body temperature by RANKL/RANK.

Nature

Hanada R,Leibbrandt A,Hanada T,Kitaoka S,Furuyashiki T,Fujihara H,Trichereau J,Paolino M,Qadri F,Plehm R,Klaere S,Komnenovic V,Mimata H,Yoshimatsu H,Takahashi N,von Haeseler A,Bader M,Kilic SS,Ueta Y,Pifl C,Narumiya S,Penninger JM

Thu Nov 26 00:00:00 EST 2009

In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations.

Blood

Carlson MJ,West ML,Coghill JM,Panoskaltsis-Mortari A,Blazar BR,Serody JS

Thu Feb 05 00:00:00 EST 2009

Interferon beta induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation.

Blood

Yen JH,Ganea D

Thu Aug 13 00:00:00 EDT 2009

Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.

Blood

Koenen RR,Pruessmeyer J,Soehnlein O,Fraemohs L,Zernecke A,Schwarz N,Reiss K,Sarabi A,Lindbom L,Hackeng TM,Weber C,Ludwig A

Thu May 07 00:00:00 EDT 2009

Wound healing defect of Vav3-/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils.

Blood

Sindrilaru A,Peters T,Schymeinsky J,Oreshkova T,Wang H,Gompf A,Mannella F,Wlaschek M,Sunderkötter C,Rudolph KL,Walzog B,Bustelo XR,Fischer KD,Scharffetter-Kochanek K

Thu May 21 00:00:00 EDT 2009

Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells.

Blood

Milsom MD,Schiedlmeier B,Bailey J,Kim MO,Li D,Jansen M,Ali AM,Kirby M,Baum C,Fairbairn LJ,Williams DA

Thu May 21 00:00:00 EDT 2009

TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans.

The Journal of clinical investigation

Washington AV,Gibot S,Acevedo I,Gattis J,Quigley L,Feltz R,De La Mota A,Schubert RL,Gomez-Rodriguez J,Cheng J,Dutra A,Pak E,Chertov O,Rivera L,Morales J,Lubkowski J,Hunter R,Schwartzberg PL,McVicar DW

Mon Jun 01 00:00:00 EDT 2009

The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells.

The Journal of experimental medicine

Maddaluno L,Verbrugge SE,Martinoli C,Matteoli G,Chiavelli A,Zeng Y,Williams ED,Rescigno M,Cavallaro U

Mon Mar 16 00:00:00 EDT 2009

External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers.

The Journal of experimental medicine

Kubo A,Nagao K,Yokouchi M,Sasaki H,Amagai M

Mon Dec 21 00:00:00 EST 2009

Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.

The Journal of experimental medicine

Lee CG,Hartl D,Lee GR,Koller B,Matsuura H,Da Silva CA,Sohn MH,Cohn L,Homer RJ,Kozhich AA,Humbles A,Kearley J,Coyle A,Chupp G,Reed J,Flavell RA,Elias JA

Mon May 11 00:00:00 EDT 2009

Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis.

The Journal of experimental medicine

Jakus Z,Simon E,Frommhold D,Sperandio M,Mócsai A

Mon Mar 16 00:00:00 EDT 2009

The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice.

The EMBO journal

Marchetti S,Gamas P,Belhacène N,Grosso S,Pradelli LA,Colosetti P,Johansen C,Iversen L,Deckert M,Luciano F,Hofman P,Ortonne N,Khemis A,Mari B,Ortonne JP,Ricci JE,Auberger P

Wed Aug 19 00:00:00 EDT 2009

CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes.

Proceedings of the National Academy of Sciences of the United States of America

Niedermeier M,Reich B,Rodriguez Gomez M,Denzel A,Schmidbauer K,Göbel N,Talke Y,Schweda F,Mack M

Tue Oct 20 00:00:00 EDT 2009

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Ben-Sasson SZ,Hu-Li J,Quiel J,Cauchetaux S,Ratner M,Shapira I,Dinarello CA,Paul WE

Tue Apr 28 00:00:00 EDT 2009

Etanercept prevents airway hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs.

British journal of pharmacology

Nie Z,Jacoby DB,Fryer AD

315-01A was used in Cell Culture to study the mechanism behind TNF-alpha mediated hyperactivity in asthmatic patients by testing whether blocking of TNF-alpha receptors with etanercept prevents M(2) receptor dysfunction and airway hyperreactivity in antigen-challenged guinea pigs.

Thu Jan 01 00:00:00 EST 2009

Caspase-2 activation in the absence of PIDDosome formation.

The Journal of cell biology

Manzl C,Krumschnabel G,Bock F,Sohm B,Labi V,Baumgartner F,Logette E,Tschopp J,Villunger A

Mon Apr 20 00:00:00 EDT 2009

Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death.

PLoS pathogens

Zhao YO,Khaminets A,Hunn JP,Howard JC

Sun Feb 01 00:00:00 EST 2009

Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages.

Journal of leukocyte biology

Choi BS,Martinez-Falero IC,Corset C,Munder M,Modolell M,Müller I,Kropf P

Sun Feb 01 00:00:00 EST 2009

The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis.

Journal of immunology (Baltimore, Md. : 1950)

D'Ambrosi N,Finocchi P,Apolloni S,Cozzolino M,Ferri A,Padovano V,Pietrini G,Carrì MT,Volonté C

Thu Oct 01 00:00:00 EDT 2009

Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways.

Journal of immunology (Baltimore, Md. : 1950)

Aleyas AG,George JA,Han YW,Rahman MM,Kim SJ,Han SB,Kim BS,Kim K,Eo SK

Sat Aug 15 00:00:00 EDT 2009

Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells.

Journal of immunology (Baltimore, Md. : 1950)

Maue AC,Eaton SM,Lanthier PA,Sweet KB,Blumerman SL,Haynes L

Fri May 15 00:00:00 EDT 2009

Absence of the transcriptional repressor Blimp-1 in hematopoietic lineages reveals its role in dendritic cell homeostatic development and function.

Journal of immunology (Baltimore, Md. : 1950)

Chan YH,Chiang MF,Tsai YC,Su ST,Chen MH,Hou MS,Lin KI

Tue Dec 01 00:00:00 EST 2009

Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts.

Journal of immunology (Baltimore, Md. : 1950)

Yoshimi R,Chang TH,Wang H,Atsumi T,Morse HC,Ozato K

Mon Jun 15 00:00:00 EDT 2009

Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.

Journal of immunology (Baltimore, Md. : 1950)

Hamada H,Garcia-Hernandez Mde L,Reome JB,Misra SK,Strutt TM,McKinstry KK,Cooper AM,Swain SL,Dutton RW

Sun Mar 15 00:00:00 EDT 2009

Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation.

Journal of immunology (Baltimore, Md. : 1950)

Franchi L,Eigenbrod T,Núñez G

Wed Jul 15 00:00:00 EDT 2009

The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Claudio E,Sønder SU,Saret S,Carvalho G,Ramalingam TR,Wynn TA,Chariot A,Garcia-Perganeda A,Leonardi A,Paun A,Chen A,Ren NY,Wang H,Siebenlist U

Sun Feb 01 00:00:00 EST 2009

4-1BB functions as a survival factor in dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Choi BK,Kim YH,Kwon PM,Lee SC,Kang SW,Kim MS,Lee MJ,Kwon BS

Wed Apr 01 00:00:00 EDT 2009

CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching/effacing lesion-forming bacterial pathogen.

Journal of immunology (Baltimore, Md. : 1950)

Spehlmann ME,Dann SM,Hruz P,Hanson E,McCole DF,Eckmann L

Tue Sep 01 00:00:00 EDT 2009

Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism.

Journal of immunology (Baltimore, Md. : 1950)

Podgrabinska S,Kamalu O,Mayer L,Shimaoka M,Snoeck H,Randolph GJ,Skobe M

Sat Aug 01 00:00:00 EDT 2009

Antigen receptor signals rescue B cells from TLR tolerance.

Journal of immunology (Baltimore, Md. : 1950)

Poovassery JS,Vanden Bush TJ,Bishop GA

Tue Sep 01 00:00:00 EDT 2009

FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response.

Journal of immunology (Baltimore, Md. : 1950)

Montfort A,de Badts B,Douin-Echinard V,Martin PG,Iacovoni J,Nevoit C,Therville N,Garcia V,Bertrand MA,Bessières MH,Trombe MC,Levade T,Benoist H,Ségui B

Thu Oct 15 00:00:00 EDT 2009

Tumor necrosis factor-alpha-mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter.

The Journal of biological chemistry

Park KM,Yule DI,Bowers WJ

Fri Oct 02 00:00:00 EDT 2009

Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome.

The Journal of biological chemistry

Lehtinen MJ,Rops AL,Isenman DE,van der Vlag J,Jokiranta TS

Fri Jun 05 00:00:00 EDT 2009

P-glycoprotein acts as an immunomodulator during neuroinflammation.

PloS one

Kooij G,Backer R,Koning JJ,Reijerkerk A,van Horssen J,van der Pol SM,Drexhage J,Schinkel A,Dijkstra CD,den Haan JM,Geijtenbeek TB,de Vries HE

Tue Dec 08 00:00:00 EST 2009

Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling.

The Journal of biological chemistry

Nold-Petry CA,Nold MF,Nielsen JW,Bustamante A,Zepp JA,Storm KA,Hong JW,Kim SH,Dinarello CA

Fri Sep 18 00:00:00 EDT 2009

Biogenic synthesis, purification, and chemical characterization of anti-inflammatory resolvins derived from docosapentaenoic acid (DPAn-6).

The Journal of biological chemistry

Dangi B,Obeng M,Nauroth JM,Teymourlouei M,Needham M,Raman K,Arterburn LM

Fri May 29 00:00:00 EDT 2009

Modulation of the antitumor immune response by complement.

Nature immunology

Markiewski MM,DeAngelis RA,Benencia F,Ricklin-Lichtsteiner SK,Koutoulaki A,Gerard C,Coukos G,Lambris JD

315-01A was used in Cell Culture to investigate C5a in the tumour microenvironment affects on tumour growth and CD8+ T cells.

Sat Nov 01 00:00:00 EDT 2008

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.

The Journal of experimental medicine

Notley CA,Inglis JJ,Alzabin S,McCann FE,McNamee KE,Williams RO

Mon Oct 27 00:00:00 EDT 2008

Celecoxib potently inhibits TNFalpha-induced nuclear translocation and activation of NF-kappaB.

Biochemical pharmacology

Funakoshi-Tago M,Shimizu T,Tago K,Nakamura M,Itoh H,Sonoda Y,Kasahara T

Mon Sep 01 00:00:00 EDT 2008

Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK.

Journal of leukocyte biology

Rodriguez N,Lang R,Wantia N,Cirl C,Ertl T,Dürr S,Wagner H,Miethke T

315-01A was used in In vitro experiments to investigate nitrogen oxide production by innate immune cells and the role of this in defence against pathogens.

Mon Dec 01 00:00:00 EST 2008

Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs.

Journal of immunology (Baltimore, Md. : 1950)

Katakai T,Suto H,Sugai M,Gonda H,Togawa A,Suematsu S,Ebisuno Y,Katagiri K,Kinashi T,Shimizu A

Sat Nov 01 00:00:00 EDT 2008

Herpes virus oncolytic therapy reverses tumor immune dysfunction and facilitates tumor antigen presentation.

Cancer biology & therapy

Benencia F,Courrèges MC,Fraser NW,Coukos G

315-01A was used in Cell Culture to show how oncolytic HSV-1716 generates vaccination effects and that that oncolytic therapy with HSV-1716 facilitates antitumor immune responses.

Fri Aug 01 00:00:00 EDT 2008

The interferon-gamma-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3.

Cellular signalling

Harris SM,Harvey EJ,Hughes TR,Ramji DP

Mon Dec 01 00:00:00 EST 2008

Modulation of murine bone marrow-derived dendritic cells and B-cells by MCS-18 a natural product isolated from Helleborus purpurascens.

Immunobiology

Littmann L,Rössner S,Kerek F,Steinkasserer A,Zinser E

Thu Feb 05 00:00:00 EST 2009

Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.

The Journal of biological chemistry

Shibata H,Yoshioka Y,Ohkawa A,Minowa K,Mukai Y,Abe Y,Taniai M,Nomura T,Kayamuro H,Nabeshi H,Sugita T,Imai S,Nagano K,Yoshikawa T,Fujita T,Nakagawa S,Yamamoto A,Ohta T,Hayakawa T,Mayumi T,Vandenabeele P,Aggarwal BB,Nakamura T,Yamagata Y,Tsunoda S,Kamada H,Tsutsumi Y

Fri Jan 11 00:00:00 EST 2008

Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.

The Journal of biological chemistry

Fri Jan 11 00:00:00 EST 2008

CXCL10 blockade protects mice from cyclophosphamide-induced cystitis.

Journal of immune based therapies and vaccines

Sakthivel SK,Singh UP,Singh S,Taub DD,Novakovic KR,Lillard JW

Tue Oct 28 00:00:00 EDT 2008

TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.

The Journal of clinical investigation

Li J,Sejas DP,Zhang X,Qiu Y,Nattamai KJ,Rani R,Rathbun KR,Geiger H,Williams DA,Bagby GC,Pang Q

Thu Nov 01 00:00:00 EDT 2007

IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B

Sat Dec 15 00:00:00 EST 2007

Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy.

Gastroenterology

Kiesslich R,Goetz M,Angus EM,Hu Q,Guan Y,Potten C,Allen T,Neurath MF,Shroyer NF,Montrose MH,Watson AJ

315-01A was used in In vivo experiments to suggest that the sealing of epithelial gaps must be considered as a component of the intestinal barrier and has potential implications for intestinal barrier dysfunction in human disease.

Sat Dec 01 00:00:00 EST 2007

A regulatory effect of the balance between TNF-alpha and IL-6 in the granulomatous and inflammatory response to Rhodococcus aurantiacus infection in mice.

Journal of immunology (Baltimore, Md. : 1950)

Kohanawa M

Sat Jul 01 00:00:00 EDT 2006

TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha.

Journal of immunology (Baltimore, Md. : 1950)

Andrade RM,Wessendarp M,Portillo JA,Yang JQ,Gomez FJ,Durbin JE,Bishop GA,Subauste CS

Tue Nov 01 00:00:00 EST 2005

IL-12/IL-18-dependent IFN-gamma release by murine dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Stober D,Schirmbeck R,Reimann J

315-01A was used in In vitro experiments to study how dendritic cells (DCs) are a source of early IFN-gamma generated in response to a cascade of cytokine- and/or cell derived signals that can be positively and negatively regulated.

Sun Jul 15 00:00:00 EDT 2001

Interleukin 4 and 13 participation in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation: multiparameter analysis of cellular recruitment, chemokine expression and cytokine networks.

Cytokine

Ruth JH,Warmington KS,Shang X,Lincoln P,Evanoff H,Kunkel SL,Chensue SW

Mon May 01 00:00:00 EDT 2000

Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation.

The Journal of experimental medicine

Munder M,Mallo M,Eichmann K,Modolell M

Mon Jun 15 00:00:00 EDT 1998

Bioinformatics

Protein Aliases: Cachectin; DADB-70P7.1; TNF alpha; TNF superfamily; TNF α; TNF-a; TNF-alpha; TNFα; Tumor necrosis factor; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha

Mouse TNF-alpha Recombinant Protein, PeproTech®

Mouse TNF-alpha Protein (315-01A-20UG) in Functional

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315-01A-20UG

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