Product References
PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen.
The Journal of experimental medicine
Liu M,Wu C,Luo S,Hua Q,Chen HT,Weng Y,Xu J,Lin H,Wang L,Li J,Zhu L,Guo Z,Zhuang SM,Kang T,Zheng L
315-14 was used in Sample Preparation (FC/FACS) to indicate that PERK-mediated HSPC preconditioning plays a crucial role in MDSC generation, suggesting novel spleen-targeting therapeutic opportunities for restraining the tumor-promoting myeloid response at its source.
Mon Apr 04 00:00:00 EDT 2022
Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.
The Journal of experimental medicine
Ahmed N,Etzrodt M,Dettinger P,Kull T,Loeffler D,Hoppe PS,Chavez JS,Zhang Y,Camargo Ortega G,Hilsenbeck O,Nakajima H,Pietras EM,Schroeder T
Mon Jan 03 00:00:00 EST 2022
Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21.
Blood cancer discovery
Zhang CR,Ostrander EL,Kukhar O,Mallaney C,Sun J,Haussler E,Celik H,Koh WK,King KY,Gontarz P,Challen GA
315-14 was used in Cell Culture to identify a previously undescribed mechanism to explain increased fitness of DNMT3A-mutant clones under hematopoietic stress.
Thu May 05 00:00:00 EDT 2022
JAK2-V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality.
Blood
Rao TN,Hansen N,Stetka J,Luque Paz D,Kalmer M,Hilfiker J,Endele M,Ahmed N,Kubovcakova L,Rybarikova M,Hao-Shen H,Geier F,Beisel C,Dirnhofer S,Schroeder T,Brümmendorf TH,Wolf D,Koschmieder S,Skoda RC
Thu Apr 22 00:00:00 EDT 2021
Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging.
Cell stem cell
Kruta M,Sunshine MJ,Chua BA,Fu Y,Chawla A,Dillingham CH,Hidalgo San Jose L,De Jong B,Zhou FJ,Signer RAJ
Thu Nov 04 00:00:00 EDT 2021
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis.
Cell stem cell
Leimkühler NB,Gleitz HFE,Ronghui L,Snoeren IAM,Fuchs SNR,Nagai JS,Banjanin B,Lam KH,Vogl T,Kuppe C,Stalmann USA,Büsche G,Kreipe H,Gütgemann I,Krebs P,Banz Y,Boor P,Tai EW,Brümmendorf TH,Koschmieder S,Crysandt M,Bindels E,Kramann R,Costa IG,Schneider RK
Thu Apr 01 00:00:00 EDT 2021
HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.
Cell stem cell
Lv K,Gong C,Antony C,Han X,Ren JG,Donaghy R,Cheng Y,Pellegrino S,Warren AJ,Paralkar VR,Tong W
315-14 was used in In vitro experiments to reveal a role of the E3 ubiquitin ligase HectD1 in regulating HSC function via ribosome assembly and protein translation.
Thu Jul 01 00:00:00 EDT 2021
Liver X receptor β is required for the survival of single-positive thymocytes by regulating IL-7Rα expression.
Cellular & molecular immunology
Huang H,Wu X,Meng D,Feng Y,Zhou L,Liu Z,Tang S,Li X,Cao Y,He H,Xie Z,Zhang J,Chen Y,Zhao T,Wu Y,Zhou X
315-14 was used in Cell Culture to indicate that LXRβ functions as an important transcription factor upstream of IL-7Rα to promote the survival of SP thymocytes.
Sun Aug 01 00:00:00 EDT 2021
SRSF1 plays a critical role in invariant natural killer T cell development and function.
Cellular & molecular immunology
Liu J,You M,Yao Y,Ji C,Wang Z,Wang F,Wang D,Qi Z,Yu G,Sun Z,Guo W,Liu J,Li S,Jin Y,Zhao T,Xue HH,Xue Y,Yu S
Mon Nov 01 00:00:00 EDT 2021
Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.
The Journal of experimental medicine
Cova G,Taroni C,Deau MC,Cai Q,Mittelheisser V,Philipps M,Jung M,Cerciat M,Le Gras S,Thibault-Carpentier C,Jost B,Carlsson L,Thornton AM,Shevach EM,Kirstetter P,Kastner P,Chan S
Mon Oct 04 00:00:00 EDT 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Mon Jul 05 00:00:00 EDT 2021
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.
EMBO molecular medicine
Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P
Fri Mar 05 00:00:00 EST 2021
Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.
Leukemia
Thomas ME,Abdelhamed S,Hiltenbrand R,Schwartz JR,Sakurada SM,Walsh M,Song G,Ma J,Pruett-Miller SM,Klco JM
Mon Nov 01 00:00:00 EDT 2021
Granulocyte colony-stimulating factor directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells.
Haematologica
Xie M,Zhang S,Dong F,Zhang Q,Wang J,Wang C,Zhu C,Zhang S,Luo B,Wu P,Ema H
315-14 was used in Cell Culture to investigate whether granulocyte colony-stimulating factor directly stimulates hematopoietic stem cells to change their cell cycle state and fate.
Tue Jun 01 00:00:00 EDT 2021
C/EBP homologous protein deficiency enhances hematopoietic stem cell function via reducing ATF3/ROS-induced cell apoptosis.
Aging cell
Shi Z,Diao D,Zhao Y,Luo Y,Li Y,Liu D,Zhang K,Qiu Y,Yu L,Song Z,Ju Z
315-14 was used in Cell Culture to show that C/EBP homologous protein (CHOP) has a significant role in supporting HSCs homesotasis and by reducing ATF3/ROS signalling, it promotes their regeneration.
Thu Jul 01 00:00:00 EDT 2021
Regeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response.
EMBO reports
Gutiérrez-Gutiérrez Ó,Felix DA,Salvetti A,Amro EM,Thems A,Pietsch S,Koeberle A,Rudolph KL,González-Estévez C
Wed Aug 04 00:00:00 EDT 2021
CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis.
Blood advances
Gerosa RC,Boettcher S,Kovtonyuk LV,Hausmann A,Hardt WD,Hidalgo J,Nombela-Arrieta C,Manz MG
Tue Dec 14 00:00:00 EST 2021
Ablation of collagen VI leads to the release of platelets with altered function.
Blood advances
Abbonante V,Gruppi C,Battiston M,Zulian A,Di Buduo CA,Chrisam M,Sereni L,Laurent PA,Semplicini C,Lombardi E,Mazzucato M,Moccia F,Petronilli V,Villa A,Bello L,Pegoraro E,Bernardi P,Braghetta P,De Marco L,Bonaldo P,Balduini A
Tue Dec 14 00:00:00 EST 2021
5-Azacytidine depletes HSCs and synergizes with an anti-CD117 antibody to augment donor engraftment in immunocompetent mice.
Blood advances
Bankova AK,Pang WW,Velasco BJ,Long-Boyle JR,Shizuru JA
Tue Oct 12 00:00:00 EDT 2021
A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.
Computational and structural biotechnology journal
Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F
315-14 was used in In vitro experiments to present a rapid experimental approach to identify potential drug targets related to mature immune cells, as well as normal and malignant hematopoiesis.
Wed Nov 10 00:00:00 EST 2021
Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
Cell death & disease
Yan R,Ge X,Pang N,Ye H,Yuan L,Cheng B,Zhou K,Yang M,Sun Y,Zhang S,Ding Z,Luo J,Ruan C,Dai K
Sat Oct 16 00:00:00 EDT 2021
Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses.
Cell reports
Yu K,Hammerschmidt SI,Permanyer M,Galla M,Rothe M,Zheng X,Werth K,Martens R,Lueder Y,Janssen A,Friedrichsen M,Bernhardt G,Förster R
Tue Jun 22 00:00:00 EDT 2021
Syngeneic leukemia models using lentiviral transgenics.
Cell death & disease
Keinan N,Scharff Y,Goldstein O,Chamo M,Ilic S,Gazit R
Thu Feb 18 00:00:00 EST 2021
GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis.
Cell death & disease
Hu Q,Zhang Y,Lou H,Ou Z,Liu J,Duan W,Wang H,Ge Y,Min J,Wang F,Ju Z
Thu Jul 15 00:00:00 EDT 2021
High-throughput enrichment and isolation of megakaryocyte progenitor cells from the mouse bone marrow.
Scientific reports
Bush LM,Healy CP,Marvin JE,Deans TL
Thu Apr 15 00:00:00 EDT 2021
Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory.
Scientific reports
Stahlhut M,Ha TC,Takmakova E,Morgan MA,Schwarzer A,Schaudien D,Eder M,Schambach A,Kustikova OS
Fri Mar 05 00:00:00 EST 2021
Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells.
Science advances
Pessoa Rodrigues C,Akhtar A
315-14 was used in Cell Culture to indicate H4K16ac as an important determinant for HSC heterogeneity, which is linked to the onset of monocytic disorders.
Sun Aug 01 00:00:00 EDT 2021
TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9.
iScience
Zhao J,Xiu Y,Fu L,Dong Q,Borcherding N,Wang Y,Li Q,De Silva NS,Klein U,Boyce BF,Zhao C
315-14 was used in Cell Culture to investigate NF-kB deletion effects on MLL-AF9-AML.
Fri Dec 17 00:00:00 EST 2021
TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.
Cell reports
Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R
Tue Jul 13 00:00:00 EDT 2021
GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis.
Blood science (Baltimore, Md.)
Yang X,Cong T,He H,Wang J
315-14 was used in Cell Culture to reveal that GSDME modulates HSC function by coordinating pyroptosis and apoptosis.
Thu Apr 01 00:00:00 EDT 2021
OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy.
Cell reports
Murakami K,Kurotaki D,Kawase W,Soma S,Fukuchi Y,Kunimoto H,Yoshimi R,Koide S,Oshima M,Hishiki T,Hayakawa N,Matsuura T,Oda M,Yanagisawa K,Kobayashi H,Haraguchi M,Atobe Y,Funakoshi K,Iwama A,Takubo K,Okamoto S,Tamura T,Nakajima H
Tue Jan 05 00:00:00 EST 2021
Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector.
Molecular therapy. Methods & clinical development
Seymour BJ,Singh S,Certo HM,Sommer K,Sather BD,Khim S,Clough C,Hale M,Pangallo J,Ryu BY,Khan IF,Adair JE,Rawlings DJ
Fri Mar 12 00:00:00 EST 2021
Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells.
Immunity
Lefkopoulos S,Polyzou A,Derecka M,Bergo V,Clapes T,Cauchy P,Jerez-Longres C,Onishi-Seebacher M,Yin N,Martagon-Calderón NA,Potts KS,Klaeylé L,Liu F,Bowman TV,Jenuwein T,Mione MC,Trompouki E
Tue Nov 17 00:00:00 EST 2020
SIRT1 is downregulated by autophagy in senescence and ageing.
Nature cell biology
Xu C,Wang L,Fozouni P,Evjen G,Chandra V,Jiang J,Lu C,Nicastri M,Bretz C,Winkler JD,Amaravadi R,Garcia BA,Adams PD,Ott M,Tong W,Johansen T,Dou Z,Berger SL
315-14 was used in In vitro experiments to investigate SIRT1 homeostasis in mammalian senescence and aging.
Thu Oct 01 00:00:00 EDT 2020
Aging-induced IL27Ra signaling impairs hematopoietic stem cells.
Blood
He H,Xu P,Zhang X,Liao M,Dong Q,Cong T,Tang B,Yang X,Ye M,Chang Y,Liu W,Wang X,Ju Z,Wang J
Thu Jul 09 00:00:00 EDT 2020
Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition.
Cell stem cell
Hinge A,He J,Bartram J,Javier J,Xu J,Fjellman E,Sesaki H,Li T,Yu J,Wunderlich M,Mulloy J,Kofron M,Salomonis N,Grimes HL,Filippi MD
315-14 was used in In vitro experiments to investigate the underlying role of mitochondria in hematopoietic stem cells (HSCs) to meet change of metabolic requirements during their cell cycle activity.
Thu Mar 05 00:00:00 EST 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Mon Mar 02 00:00:00 EST 2020
Membrane budding is a major mechanism of in vivo platelet biogenesis.
The Journal of experimental medicine
Potts KS,Farley A,Dawson CA,Rimes J,Biben C,de Graaf C,Potts MA,Stonehouse OJ,Carmagnac A,Gangatirkar P,Josefsson EC,Anttila C,Amann-Zalcenstein D,Naik S,Alexander WS,Hilton DJ,Hawkins ED,Taoudi S
Mon Sep 07 00:00:00 EDT 2020
Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis.
The Journal of experimental medicine
Xiong Z,Xia P,Zhu X,Geng J,Wang S,Ye B,Qin X,Qu Y,He L,Fan D,Du Y,Tian Y,Fan Z
Mon Feb 03 00:00:00 EST 2020
PEDF promotes the repair of bone marrow endothelial cell injury and accelerates hematopoietic reconstruction after bone marrow transplantation.
Journal of biomedical science
Ju W,Lu W,Ding L,Bao Y,Hong F,Chen Y,Gao H,Xu X,Wang G,Wang W,Zhang X,Fu C,Qi K,Li Z,Xu K,Qiao J,Zeng L
315-14 was used in Cell Culture to investigate pigment epithelium-derived factor's effect on preconditioning induced damage of endothelial cells and hematopoietic reconstructioncon.
Tue Sep 01 00:00:00 EDT 2020
Cyclosporine H Improves the Multi-Vector Lentiviral Transduction of Murine Haematopoietic Progenitors and Stem Cells.
Scientific reports
Olender L,Bujanover N,Sharabi O,Goldstein O,Gazit R
Tue Feb 04 00:00:00 EST 2020
Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.
Science advances
Pessoa Rodrigues C,Herman JS,Herquel B,Valsecchi CIK,Stehle T,Grün D,Akhtar A
315-14 was used in In vitro experiments to study the mechanism by which histone H4 lysine 16 acetyltransferase MOF regulates erythropoiesis.
Fri May 01 00:00:00 EDT 2020
BECN1 modulates hematopoietic stem cells by targeting Caspase-3-GSDME-mediated pyroptosis.
Blood science (Baltimore, Md.)
Yang X,Ge L,Wang J
315-14 was used in Cell Culture to investigate the role of Becn1 in hematopoietic stem cells.
Wed Jul 01 00:00:00 EDT 2020
MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia.
Nature communications
Itskovich SS,Gurunathan A,Clark J,Burwinkel M,Wunderlich M,Berger MR,Kulkarni A,Chetal K,Venkatasubramanian M,Salomonis N,Kumar AR,Lee LH
Tue May 12 00:00:00 EDT 2020
Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance.
Nature communications
Barbier V,Erbani J,Fiveash C,Davies JM,Tay J,Tallack MR,Lowe J,Magnani JL,Pattabiraman DR,Perkins AC,Lisle J,Rasko JEJ,Levesque JP,Winkler IG
Mon Apr 27 00:00:00 EDT 2020
Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.
Immunity
Tyrkalska SD,Pérez-Oliva AB,Rodríguez-Ruiz L,Martínez-Morcillo FJ,Alcaraz-Pérez F,Martínez-Navarro FJ,Lachaud C,Ahmed N,Schroeder T,Pardo-Sánchez I,Candel S,López-Muñoz A,Choudhuri A,Rossmann MP,Zon LI,Cayuela ML,García-Moreno D,Mulero V
Tue Jul 16 00:00:00 EDT 2019
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Cancer cell
Labuhn M,Perkins K,Matzk S,Varghese L,Garnett C,Papaemmanuil E,Metzner M,Kennedy A,Amstislavskiy V,Risch T,Bhayadia R,Samulowski D,Hernandez DC,Stoilova B,Iotchkova V,Oppermann U,Scheer C,Yoshida K,Schwarzer A,Taub JW,Crispino JD,Weiss MJ,Hayashi Y,Taga T,Ito E,Ogawa S,Reinhardt D,Yaspo ML,Campbell PJ,Roberts I,Constantinescu SN,Vyas P,Heckl D,Klusmann JH
Mon Aug 12 00:00:00 EDT 2019
γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia.
Cancer cell
Luong-Gardiol N,Siddiqui I,Pizzitola I,Jeevan-Raj B,Charmoy M,Huang Y,Irmisch A,Curtet S,Angelov GS,Danilo M,Juilland M,Bornhauser B,Thome M,Hantschel O,Chalandon Y,Cazzaniga G,Bourquin JP,Huelsken J,Held W
Mon Apr 15 00:00:00 EDT 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
315-14 was used in Cell Culture to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 EDT 2019
Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.
The Journal of experimental medicine
Chen Z,Amro EM,Becker F,Hölzer M,Rasa SMM,Njeru SN,Han B,Di Sanzo S,Chen Y,Tang D,Tao S,Haenold R,Groth M,Romanov VS,Kirkpatrick JM,Kraus JM,Kestler HA,Marz M,Ori A,Neri F,Morita Y,Rudolph KL
315-14 was used in In vitro experiments to determine hematopoietic stem cell function is limited by Rad21/cohesin-mediated NF-kB signaling during aging.
Mon Jan 07 00:00:00 EST 2019
EDA fibronectin-TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis.
The Journal of experimental medicine
Malara A,Gruppi C,Abbonante V,Cattaneo D,De Marco L,Massa M,Iurlo A,Gianelli U,Balduini CL,Tira ME,Muro AF,Chauhan AK,Rosti V,Barosi G,Balduini A
Mon Mar 04 00:00:00 EST 2019
Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis.
The Journal of experimental medicine
Anzai A,Mindur JE,Halle L,Sano S,Choi JL,He S,McAlpine CS,Chan CT,Kahles F,Valet C,Fenn AM,Nairz M,Rattik S,Iwamoto Y,Fairweather D,Walsh K,Libby P,Nahrendorf M,Swirski FK
Mon Feb 04 00:00:00 EST 2019
The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.
The EMBO journal
Sainz de Aja J,Menchero S,Rollan I,Barral A,Tiana M,Jawaid W,Cossio I,Alvarez A,Carreño-Tarragona G,Badia-Careaga C,Nichols J,Göttgens B,Isern J,Manzanares M
Mon Apr 01 00:00:00 EDT 2019
p53-TP53-Induced Glycolysis Regulator Mediated Glycolytic Suppression Attenuates DNA Damage and Genomic Instability in Fanconi Anemia Hematopoietic Stem Cells.
Stem cells (Dayton, Ohio)
Li X,Wu L,Zopp M,Kopelov S,Du W
Mon Jul 01 00:00:00 EDT 2019
Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.
Cell reports
Luo H,Mu WC,Karki R,Chiang HH,Mohrin M,Shin JJ,Ohkubo R,Ito K,Kanneganti TD,Chen D
315-14 was used in Cell Culture to assess whether the NLRP3 inflammasome is aberrantly activated in haematopoietic stem cells during physiological ageing.
Tue Jan 22 00:00:00 EST 2019
Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function.
Scientific reports
Moore SF,Smith NR,Blair TA,Durrant TN,Hers I
Wed Feb 06 00:00:00 EST 2019
All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.
Cell death & disease
Nguyen CH,Bauer K,Hackl H,Schlerka A,Koller E,Hladik A,Stoiber D,Zuber J,Staber PB,Hoelbl-Kovacic A,Purton LE,Grebien F,Wieser R
Tue Dec 10 00:00:00 EST 2019
Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome.
Cell stem cell
Masiuk KE,Laborada J,Roncarolo MG,Hollis RP,Kohn DB
315-14 was used in Cell Culture to demonstrate preclinical efficacy for the treatment of IPEX patients by autologous HSC transplant and may provide valuable insights into new cell therapies for autoimmunity.
Thu Feb 07 00:00:00 EST 2019
Anti-inflammatory and vasculogenic conditioning of peripheral blood mononuclear cells reinforces their therapeutic potential for radiation-injured salivary glands.
Stem cell research & therapy
I T,Sumita Y,Yoshida T,Honma R,Iwatake M,Raudales JLM,Shizuno T,Kuroshima S,Masuda H,Seki M,Tran SD,Asahara T,Asahina I
315-14 was used in Cell Culture to investigate methods conditioning peripheral blood mononuclear cells to regenerate salivary gland following head and neck cancer treatment.
Thu Oct 17 00:00:00 EDT 2019
Population snapshots predict early haematopoietic and erythroid hierarchies.
Nature
Tusi BK,Wolock SL,Weinreb C,Hwang Y,Hidalgo D,Zilionis R,Waisman A,Huh JR,Klein AM,Socolovsky M
315-14 was used in In vitro experiments to illustrate the utility of coupling population snapshots with predictive fate models, to gain in vivo insights of early hempatopoetic and erythroid lineage sorting.
Thu Mar 01 00:00:00 EST 2018
Clonal analysis of lineage fate in native haematopoiesis.
Nature
Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD
Thu Jan 11 00:00:00 EST 2018
Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.
Nature biotechnology
Kosicki M,Tomberg K,Bradley A
Sat Sep 01 00:00:00 EDT 2018
Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.
Cell
Minzel W,Venkatachalam A,Fink A,Hung E,Brachya G,Burstain I,Shaham M,Rivlin A,Omer I,Zinger A,Elias S,Winter E,Erdman PE,Sullivan RW,Fung L,Mercurio F,Li D,Vacca J,Kaushansky N,Shlush L,Oren M,Levine R,Pikarsky E,Snir-Alkalay I,Ben-Neriah Y
315-14 was used in In vitro experiments to demonstrate that the inhibitors abolish many SEs and preferentially suppress the transcription elongation of SE-driven oncogenes.
Thu Sep 20 00:00:00 EDT 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
Tue Apr 17 00:00:00 EDT 2018
Crbn I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice.
Blood
Fink EC,McConkey M,Adams DN,Haldar SD,Kennedy JA,Guirguis AA,Udeshi ND,Mani DR,Chen M,Liddicoat B,Svinkina T,Nguyen AT,Carr SA,Ebert BL
Thu Oct 04 00:00:00 EDT 2018
Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation.
Blood
Jacquelin S,Straube J,Cooper L,Vu T,Song A,Bywater M,Baxter E,Heidecker M,Wackrow B,Porter A,Ling V,Green J,Austin R,Kazakoff S,Waddell N,Hesson LB,Pimanda JE,Stegelmann F,Bullinger L,Döhner K,Rampal RK,Heckl D,Hill GR,Lane SW
Thu Dec 27 00:00:00 EST 2018
Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML.
Cell stem cell
Duarte D,Hawkins ED,Akinduro O,Ang H,De Filippo K,Kong IY,Haltalli M,Ruivo N,Straszkowski L,Vervoort SJ,McLean C,Weber TS,Khorshed R,Pirillo C,Wei A,Ramasamy SK,Kusumbe AP,Duffy K,Adams RH,Purton LE,Carlin LM,Lo Celso C
315-14 was used in Cell Culture to suggest that preventing degradation of the endosteal vasculature may improve current paradigms for treating acute myeloid leukemia.
Thu Jan 04 00:00:00 EST 2018
Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeletal dynamics in platelets.
The Journal of clinical investigation
Hurtado B,Trakala M,Ximénez-Embún P,El Bakkali A,Partida D,Sanz-Castillo B,Álvarez-Fernández M,Maroto M,Sánchez-Martínez R,Martínez L,Muñoz J,García de Frutos P,Malumbres M
Mon Dec 03 00:00:00 EST 2018
Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.
The Journal of clinical investigation
Zhang P,He F,Bai J,Yamamoto S,Chen S,Zhang L,Sheng M,Zhang L,Guo Y,Man N,Yang H,Wang S,Cheng T,Nimer SD,Zhou Y,Xu M,Wang QF,Yang FC
Mon Dec 03 00:00:00 EST 2018
Kinetics of adult hematopoietic stem cell differentiation in vivo.
The Journal of experimental medicine
Upadhaya S,Sawai CM,Papalexi E,Rashidfarrokhi A,Jang G,Chattopadhyay P,Satija R,Reizis B
Mon Nov 05 00:00:00 EST 2018
Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response.
The Journal of experimental medicine
Barbieri D,Elvira-Matelot E,Pelinski Y,Genève L,de Laval B,Yogarajah G,Pecquet C,Constantinescu SN,Porteu F
Mon May 07 00:00:00 EDT 2018
Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1.
Journal of immunology (Baltimore, Md. : 1950)
Mumau MD,Vanderbeck AN,Lynch ED,Golec SB,Emerson SG,Punt JA
Thu Feb 01 00:00:00 EST 2018
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Cell stem cell
Qian P,De Kumar B,He XC,Nolte C,Gogol M,Ahn Y,Chen S,Li Z,Xu H,Perry JM,Hu D,Tao F,Zhao M,Han Y,Hall K,Peak A,Paulson A,Zhao C,Venkatraman A,Box A,Perera A,Haug JS,Parmely T,Li H,Krumlauf R,Li L
315-14 was used in Cell Culture to demonstrate roles for retinoid signaling and the DERARE in maintaining HSCs and preventing leukemogenesis by coordinate regulation of Hoxb genes.
Thu May 03 00:00:00 EDT 2018
MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia.
Cell death & disease
Hartmann JU,Bräuer-Hartmann D,Kardosova M,Wurm AA,Wilke F,Schödel C,Gerloff D,Katzerke C,Krakowsky R,Namasu CY,Bill M,Schwind S,Müller-Tidow C,Niederwieser D,Alberich-Jorda M,Behre G
Thu Jul 26 00:00:00 EDT 2018
The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells.
Cell death & disease
Liu T,Kong WX,Tang XY,Xu M,Wang QH,Zhang B,Hu LD,Chen H
Thu Jun 07 00:00:00 EDT 2018
Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow.
Stem cell reports
Karatepe K,Zhu H,Zhang X,Guo R,Kambara H,Loison F,Liu P,Yu H,Ren Q,Luo X,Manis J,Cheng T,Ma F,Xu Y,Luo HR
Tue Nov 13 00:00:00 EST 2018
Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.
Nature communications
Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM
Tue Jan 02 00:00:00 EST 2018
Elevated Oxidative Stress Impairs Hematopoietic Progenitor Function in C57BL/6 Substrains.
Stem cell reports
Morales-Hernández A,Martinat A,Chabot A,Kang G,McKinney-Freeman S
Tue Aug 14 00:00:00 EDT 2018
Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation.
Cell reports
Nakamura-Ishizu A,Matsumura T,Stumpf PS,Umemoto T,Takizawa H,Takihara Y,O'Neil A,Majeed ABBA,MacArthur BD,Suda T
315-14 was used in Cell Culture to report an important role for thrombopoietin in regulating rapid megakaryocyte-lineage commitment.
Tue Nov 13 00:00:00 EST 2018
Plexin-B2 Mediates Physiologic and Pathologic Functions of Angiogenin.
Cell
Yu W,Goncalves KA,Li S,Kishikawa H,Sun G,Yang H,Vanli N,Wu Y,Jiang Y,Hu MG,Friedel RH,Hu GF
Thu Nov 02 00:00:00 EDT 2017
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cell
Cabezas-Wallscheid N,Buettner F,Sommerkamp P,Klimmeck D,Ladel L,Thalheimer FB,Pastor-Flores D,Roma LP,Renders S,Zeisberger P,Przybylla A,Schönberger K,Scognamiglio R,Altamura S,Florian CM,Fawaz M,Vonficht D,Tesio M,Collier P,Pavlinic D,Geiger H,Schroeder T,Benes V,Dick TP,Rieger MA,Stegle O,Trumpp A
Thu May 18 00:00:00 EDT 2017
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.
Cancer cell
Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C,Kuchenbauer F,Schütz E,Green AR,Urlaub H,Stegmaier K,Humphries RK,Serve H,Oellerich T
Mon Apr 10 00:00:00 EDT 2017
Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis.
Blood
Machlus KR,Wu SK,Vijey P,Soussou TS,Liu ZJ,Shacham E,Unger TJ,Kashyap T,Klebanov B,Sola-Visner M,Crochiere M,Italiano JE,Landesman Y
Thu Aug 31 00:00:00 EDT 2017
Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis.
Blood
Machlus KR,Wu SK,Vijey P,Soussou TS,Liu ZJ,Shacham E,Unger TJ,Kashyap T,Klebanov B,Sola-Visner M,Crochiere M,Italiano JE,Landesman Y
Thu Aug 31 00:00:00 EDT 2017
Osteoblasts support megakaryopoiesis through production of interleukin-9.
Blood
Xiao M,Wang Y,Tao C,Wang Z,Yang J,Chen Z,Zou Z,Li M,Liu A,Jia C,Huang B,Yan B,Lai P,Ding C,Cai D,Xiao G,Jiang Y,Bai X
Thu Jun 15 00:00:00 EDT 2017
27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy.
The Journal of clinical investigation
Oguro H,McDonald JG,Zhao Z,Umetani M,Shaul PW,Morrison SJ
Fri Sep 01 00:00:00 EDT 2017
Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression.
The Journal of experimental medicine
Kim E,Cheng Y,Bolton-Gillespie E,Cai X,Ma C,Tarangelo A,Le L,Jambhekar M,Raman P,Hayer KE,Wertheim G,Speck NA,Tong W,Viatour P
Mon Jul 03 00:00:00 EDT 2017
Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies.
The Journal of experimental medicine
Tanaka T,Nakajima-Takagi Y,Aoyama K,Tara S,Oshima M,Saraya A,Koide S,Si S,Manabe I,Sanada M,Nakayama M,Masuko M,Sone H,Koseki H,Iwama A
Mon Oct 02 00:00:00 EDT 2017
Preclinical modeling of myelodysplastic syndromes.
Leukemia
Rouault-Pierre K,Mian SA,Goulard M,Abarrategi A,Di Tulio A,Smith AE,Mohamedali A,Best S,Nloga AM,Kulasekararaj AG,Ades L,Chomienne C,Fenaux P,Dosquet C,Mufti GJ,Bonnet D
Fri Dec 01 00:00:00 EST 2017
Generation of an osteoblast-based artificial niche that supports in vitro B lymphopoiesis.
Experimental & molecular medicine
Yu J,Choi S,Kim H,Lee N,Yun H,Kim S,Jeong ST,Rho J
Fri Nov 24 00:00:00 EST 2017
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation.
Nature communications
Hinge A,Xu J,Javier J,Mose E,Kumar S,Kapur R,Srour EF,Malik P,Aronow BJ,Filippi MD
Wed Feb 08 00:00:00 EST 2017
The Plant Hormone Abscisic Acid Is a Prosurvival Factor in Human and Murine Megakaryocytes.
The Journal of biological chemistry
Malara A,Fresia C,Di Buduo CA,Soprano PM,Moccia F,Balduini C,Zocchi E,De Flora A,Balduini A
Fri Feb 24 00:00:00 EST 2017
Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.
The Journal of biological chemistry
Nadeau SA,An W,Mohapatra BC,Mushtaq I,Bielecki TA,Luan H,Zutshi N,Ahmad G,Storck MD,Sanada M,Ogawa S,Band V,Band H
Fri Mar 03 00:00:00 EST 2017
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.
Nature communications
Ranjan S,Goihl A,Kohli S,Gadi I,Pierau M,Shahzad K,Gupta D,Bock F,Wang H,Shaikh H,Kähne T,Reinhold D,Bank U,Zenclussen AC,Niemz J,Schnöder TM,Brunner-Weinzierl M,Fischer T,Kalinski T,Schraven B,Luft T,Huehn J,Naumann M,Heidel FH,Isermann B
Mon Aug 21 00:00:00 EDT 2017
Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development.
Nature communications
Vallecillo-García P,Orgeur M,Vom Hofe-Schneider S,Stumm J,Kappert V,Ibrahim DM,Börno ST,Hayashi S,Relaix F,Hildebrandt K,Sengle G,Koch M,Timmermann B,Marazzi G,Sassoon DA,Duprez D,Stricker S
Tue Oct 31 00:00:00 EDT 2017
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.
Cell
Puram RV,Kowalczyk MS,de Boer CG,Schneider RK,Miller PG,McConkey M,Tothova Z,Tejero H,Heckl D,Järås M,Chen MC,Li H,Tamayo A,Cowley GS,Rozenblatt-Rosen O,Al-Shahrour F,Regev A,Ebert BL
Thu Apr 07 00:00:00 EDT 2016
Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq.
Cell
Jaitin DA,Weiner A,Yofe I,Lara-Astiaso D,Keren-Shaul H,David E,Salame TM,Tanay A,van Oudenaarden A,Amit I
Thu Dec 15 00:00:00 EST 2016
Identification of factors promoting ex vivo maintenance of mouse hematopoietic stem cells by long-term single-cell quantification.
Blood
Kokkaliaris KD,Drew E,Endele M,Loeffler D,Hoppe PS,Hilsenbeck O,Schauberger B,Hinzen C,Skylaki S,Theodorou M,Kieslinger M,Lemischka I,Moore K,Schroeder T
Thu Sep 01 00:00:00 EDT 2016
Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation.
Blood
Mascarenhas MI,Bacon WA,Kapeni C,Fitch SR,Kimber G,Cheng SW,Li J,Green AR,Ottersbach K
Thu May 12 00:00:00 EDT 2016
MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice.
Blood
Baba T,Tanabe Y,Yoshikawa S,Yamanishi Y,Morishita S,Komatsu N,Karasuyama H,Hirao A,Mukaida N
Thu May 26 00:00:00 EDT 2016
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
The Journal of clinical investigation
Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ
Fri Jan 01 00:00:00 EST 2016
Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.
The Journal of clinical investigation
Gu H,Chen C,Hao X,Wang C,Zhang X,Li Z,Shao H,Zeng H,Yu Z,Xie L,Xia F,Zhang F,Liu X,Zhang Y,Jiang H,Zhu J,Wan J,Wang C,Weng W,Xie J,Tao M,Zhang CC,Liu J,Chen GQ,Zheng J
Thu Dec 01 00:00:00 EST 2016
Functional screen identifies regulators of murine hematopoietic stem cell repopulation.
The Journal of experimental medicine
Holmfeldt P,Ganuza M,Marathe H,He B,Hall T,Kang G,Moen J,Pardieck J,Saulsberry AC,Cico A,Gaut L,McGoldrick D,Finkelstein D,Tan K,McKinney-Freeman S
Mon Mar 07 00:00:00 EST 2016
Multiple allogeneic progenitors in combination function as a unit to support early transient hematopoiesis in transplantation.
The Journal of experimental medicine
Ishida T,Takahashi S,Lai CY,Nojima M,Yamamoto R,Takeuchi E,Takeuchi Y,Higashihara M,Nakauchi H,Otsu M
Mon Aug 22 00:00:00 EDT 2016
Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway.
Acta pharmacologica Sinica
Kong YL,Shen Y,Ni J,Shao DC,Miao NJ,Xu JL,Zhou L,Xue H,Zhang W,Wang XX,Lu LM
Mon Feb 01 00:00:00 EST 2016
Thrombopoietin/TGF-β1 Loop Regulates Megakaryocyte Extracellular Matrix Component Synthesis.
Stem cells (Dayton, Ohio)
Abbonante V,Di Buduo CA,Gruppi C,Malara A,Gianelli U,Celesti G,Anselmo A,Laghi L,Vercellino M,Visai L,Iurlo A,Moratti R,Barosi G,Rosti V,Balduini A
Fri Apr 01 00:00:00 EDT 2016
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem cells (Dayton, Ohio)
Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA
Tue Mar 01 00:00:00 EST 2016
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem cells (Dayton, Ohio)
Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA
Tue Mar 01 00:00:00 EST 2016
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem cells (Dayton, Ohio)
Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA
Tue Mar 01 00:00:00 EST 2016
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem cells (Dayton, Ohio)
Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA
Tue Mar 01 00:00:00 EST 2016
SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells.
Stem cells (Dayton, Ohio)
Du W,Amarachintha S,Wilson AF,Pang Q
Fri Apr 01 00:00:00 EDT 2016
Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt Signaling Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Sertorio M,Amarachintha S,Wilson A,Pang Q
Fri Apr 01 00:00:00 EDT 2016
Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.
Cell death & disease
Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H
Thu Oct 06 00:00:00 EDT 2016
Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.
Cell death & disease
Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H
Thu Oct 06 00:00:00 EDT 2016
EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Scientific reports
Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G
Thu Jun 02 00:00:00 EDT 2016
EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Scientific reports
Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G
Thu Jun 02 00:00:00 EDT 2016
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.
Nature communications
Lai M,Gonzalez-Martin A,Cooper AB,Oda H,Jin HY,Shepherd J,He L,Zhu J,Nemazee D,Xiao C
Tue Aug 02 00:00:00 EDT 2016
Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.
Nature communications
Gamrekelashvili J,Giagnorio R,Jussofie J,Soehnlein O,Duchene J,Briseño CG,Ramasamy SK,Krishnasamy K,Limbourg A,Kapanadze T,Ishifune C,Hinkel R,Radtke F,Strobl LJ,Zimber-Strobl U,Napp LC,Bauersachs J,Haller H,Yasutomo K,Kupatt C,Murphy KM,Adams RH,Weber C,Limbourg FP
Wed Aug 31 00:00:00 EDT 2016
Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity.
Nature communications
Jung H,Kim DO,Byun JE,Kim WS,Kim MJ,Song HY,Kim YK,Kang DK,Park YJ,Kim TD,Yoon SR,Lee HG,Choi EJ,Min SH,Choi I
315-14 was used in Sample Preparation (FC/FACS) to study the rejuvenation of stem cells and report that the thioredoxin-interacting protein (TXNIP)-p38 mitogen-activated protein kinase (p38) axis regulates the ageing of haematopoietic stem cells (HSCs), by causing a higher frequency of long-term HSCs, lineage skewing, a decrease in engraftment, an increase in reactive oxygen species and loss of Cdc42 polarity.
Thu Dec 08 00:00:00 EST 2016
CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress.
Scientific reports
Zhang Y,Dépond M,He L,Foudi A,Kwarteng EO,Lauret E,Plo I,Desterke C,Dessen P,Fujii N,Opolon P,Herault O,Solary E,Vainchenker W,Joulin V,Louache F,Wittner M
Fri Nov 25 00:00:00 EST 2016
Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche.
Nature communications
Hu X,Garcia M,Weng L,Jung X,Murakami JL,Kumar B,Warden CD,Todorov I,Chen CC
Mon Oct 10 00:00:00 EDT 2016
Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice.
Blood
Trakala M,Partida D,Salazar-Roa M,Maroto M,Wachowicz P,de Cárcer G,Malumbres M
Thu Oct 01 00:00:00 EDT 2015
T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung.
Blood
Iriguchi S,Kikuchi N,Kaneko S,Noguchi E,Morishima Y,Matsuyama M,Yoh K,Takahashi S,Nakauchi H,Ishii Y
Thu Jan 08 00:00:00 EST 2015
MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling.
Blood
Rozenova K,Jiang J,Donaghy R,Aressy B,Greenberg RA,Tong W
Thu Mar 12 00:00:00 EDT 2015
Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.
Blood
Xiao N,Laha S,Das SP,Morlock K,Jesneck JL,Raffel GD
Thu Feb 05 00:00:00 EST 2015
RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation.
Blood
Kuvardina ON,Herglotz J,Kolodziej S,Kohrs N,Herkt S,Wojcik B,Oellerich T,Corso J,Behrens K,Kumar A,Hussong H,Urlaub H,Koch J,Serve H,Bonig H,Stocking C,Rieger MA,Lausen J
Thu Jun 04 00:00:00 EDT 2015
Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL.
Blood
Potts KS,Sargeant TJ,Dawson CA,Josefsson EC,Hilton DJ,Alexander WS,Taoudi S
Thu Aug 06 00:00:00 EDT 2015
MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.
Blood
Shaham L,Vendramini E,Ge Y,Goren Y,Birger Y,Tijssen MR,McNulty M,Geron I,Schwartzman O,Goldberg L,Chou ST,Pitman H,Weiss MJ,Michaeli S,Sredni B,Göttgens B,Crispino JD,Taub JW,Izraeli S
Thu Feb 19 00:00:00 EST 2015
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.
The Journal of clinical investigation
Park SM,Gönen M,Vu L,Minuesa G,Tivnan P,Barlowe TS,Taggart J,Lu Y,Deering RP,Hacohen N,Figueroa ME,Paietta E,Fernandez HF,Tallman MS,Melnick A,Levine R,Leslie C,Lengner CJ,Kharas MG
Mon Mar 02 00:00:00 EST 2015
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
The Journal of clinical investigation
Hadland BK,Varnum-Finney B,Poulos MG,Moon RT,Butler JM,Rafii S,Bernstein ID
Fri May 01 00:00:00 EDT 2015
Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.
The Journal of clinical investigation
Duque-Afonso J,Feng J,Scherer F,Lin CH,Wong SH,Wang Z,Iwasaki M,Cleary ML
Tue Sep 01 00:00:00 EDT 2015
Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.
The Journal of experimental medicine
Xia P,Wang S,Du Y,Huang G,Satoh T,Akira S,Fan Z
Mon Dec 14 00:00:00 EST 2015
Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Godec J,Cowley GS,Barnitz RA,Alkan O,Root DE,Sharpe AH,Haining WN
Tue Jan 13 00:00:00 EST 2015
Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy.
Molecular therapy. Methods & clinical development
Ungari S,Montepeloso A,Morena F,Cocchiarella F,Recchia A,Martino S,Gentner B,Naldini L,Biffi A
Wed Oct 28 00:00:00 EDT 2015
Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy.
Molecular therapy. Methods & clinical development
Wielgosz MM,Kim YS,Carney GG,Zhan J,Reddivari M,Coop T,Heath RJ,Brown SA,Nienhuis AW
315-14 was used in In vitro experiments to show that the producer cell line and the specific monoclonal antibody will facilitate the development of a clinical protocol for gene transfer into WAS protein deficient stem cells.
Mon Jun 08 00:00:00 EDT 2015
Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.
Stem cell reports
Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F
Tue Oct 13 00:00:00 EDT 2015
Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.
Scientific reports
Xie XQ,Yang P,Zhang Y,Zhang P,Wang L,Ding Y,Yang M,Tong Q,Cheng H,Ji Q,McGuire T,Yuan W,Cheng T,Gao Y
Fri Dec 18 00:00:00 EST 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
Mon Oct 12 00:00:00 EDT 2015
Amelioration of murine sickle cell disease by nonablative conditioning and γ-globin gene-corrected bone marrow cells.
Molecular therapy. Methods & clinical development
Pestina TI,Hargrove PW,Zhao H,Mead PE,Smeltzer MP,Weiss MJ,Wilber A,Persons DA
Tue Dec 15 00:00:00 EST 2015
The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.
Stem cell reports
Zhang J,Vakhrusheva O,Bandi SR,Demirel Ö,Kazi JU,Fernandes RG,Jakobi K,Eichler A,Rönnstrand L,Rieger MA,Carpino N,Serve H,Brandts CH
Tue Oct 13 00:00:00 EDT 2015
STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.
Nature communications
Haetscher N,Feuermann Y,Wingert S,Rehage M,Thalheimer FB,Weiser C,Bohnenberger H,Jung K,Schroeder T,Serve H,Oellerich T,Hennighausen L,Rieger MA
Wed Nov 25 00:00:00 EST 2015
Role of Erk1/2 signaling in the regulation of neutrophil versus monocyte development in response to G-CSF and M-CSF.
The Journal of biological chemistry
Hu N,Qiu Y,Dong F
Fri Oct 02 00:00:00 EDT 2015
Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.
Nature
Nakada D,Oguro H,Levi BP,Ryan N,Kitano A,Saitoh Y,Takeichi M,Wendt GR,Morrison SJ
Thu Jan 23 00:00:00 EST 2014
Nonstochastic reprogramming from a privileged somatic cell state.
Cell
Guo S,Zi X,Schulz VP,Cheng J,Zhong M,Koochaki SH,Megyola CM,Pan X,Heydari K,Weissman SM,Gallagher PG,Krause DS,Fan R,Lu J
Thu Feb 13 00:00:00 EST 2014
Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Blood
Lu EP,McLellan M,Ding L,Fulton R,Mardis ER,Wilson RK,Miller CA,Westervelt P,DiPersio JF,Link DC,Walter MJ,Ley TJ,Graubert TA
Thu Dec 18 00:00:00 EST 2014
SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury.
Blood
Niswander LM,Fegan KH,Kingsley PD,McGrath KE,Palis J
Thu Jul 10 00:00:00 EDT 2014
SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury.
Blood
Niswander LM,Fegan KH,Kingsley PD,McGrath KE,Palis J
Thu Jul 10 00:00:00 EDT 2014
Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1.
Blood
de Laval B,Pawlikowska P,Barbieri D,Besnard-Guerin C,Cico A,Kumar R,Gaudry M,Baud V,Porteu F
Thu Jan 23 00:00:00 EST 2014
Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice.
Blood
Pawlikowska P,Fouchet P,Vainchenker W,Rosselli F,Naim V
Thu Dec 04 00:00:00 EST 2014
Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.
The Journal of experimental medicine
Lancini C,van den Berk PC,Vissers JH,Gargiulo G,Song JY,Hulsman D,Serresi M,Tanger E,Blom M,Vens C,van Lohuizen M,Jacobs H,Citterio E
Mon Aug 25 00:00:00 EDT 2014
Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.
The Journal of experimental medicine
Pietras EM,Lakshminarasimhan R,Techner JM,Fong S,Flach J,Binnewies M,Passegué E
Mon Feb 10 00:00:00 EST 2014
Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation.
The Journal of experimental medicine
Ye B,Li C,Yang Z,Wang Y,Hao J,Wang L,Li Y,Du Y,Hao L,Liu B,Wang S,Xia P,Huang G,Sun L,Tian Y,Fan Z
Mon Nov 17 00:00:00 EST 2014
Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.
The Journal of experimental medicine
Järås M,Miller PG,Chu LP,Puram RV,Fink EC,Schneider RK,Al-Shahrour F,Peña P,Breyfogle LJ,Hartwell KA,McConkey ME,Cowley GS,Root DE,Kharas MG,Mullally A,Ebert BL
Mon Apr 07 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Mon Sep 22 00:00:00 EDT 2014
High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias.
The Journal of experimental medicine
Shin JY,Hu W,Naramura M,Park CY
Mon Feb 10 00:00:00 EST 2014
Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis.
Blood cancer journal
Nakaya Y,Shide K,Naito H,Niwa T,Horio T,Miyake J,Shimoda K
Fri Jan 10 00:00:00 EST 2014
Identification of multipotent progenitors that emerge prior to hematopoietic stem cells in embryonic development.
Stem cell reports
Inlay MA,Serwold T,Mosley A,Fathman JW,Dimov IK,Seita J,Weissman IL
315-14 was used in Sample Preparation (FC/FACS) to develop a single-cell multipotency assay which can be used to identify when and where clonal multilineage potential arises during embryogenesis.
Tue Apr 08 00:00:00 EDT 2014
Twist-1, a novel regulator of hematopoietic stem cell self-renewal and myeloid lineage development.
Stem cells (Dayton, Ohio)
Dong CY,Liu XY,Wang N,Wang LN,Yang BX,Ren Q,Liang HY,Ma XT
Mon Dec 01 00:00:00 EST 2014
Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.
Stem cells (Dayton, Ohio)
Povinelli BJ,Nemeth MJ
Wed Jan 01 00:00:00 EST 2014
Megakaryocytes contribute to the bone marrow-matrix environment by expressing fibronectin, type IV collagen, and laminin.
Stem cells (Dayton, Ohio)
Malara A,Currao M,Gruppi C,Celesti G,Viarengo G,Buracchi C,Laghi L,Kaplan DL,Balduini A
Tue Apr 01 00:00:00 EDT 2014
Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling.
Journal of immunology (Baltimore, Md. : 1950)
Balmer ML,Schürch CM,Saito Y,Geuking MB,Li H,Cuenca M,Kovtonyuk LV,McCoy KD,Hapfelmeier S,Ochsenbein AF,Manz MG,Slack E,Macpherson AJ
Sat Nov 15 00:00:00 EST 2014
The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression.
Cell death & disease
Becker MS,Schmezer P,Breuer R,Haas SF,Essers MA,Krammer PH,Li-Weber M
Thu Jan 16 00:00:00 EST 2014
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Nature
Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E
Thu Feb 21 00:00:00 EST 2013
Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation.
Blood
Smith EC,Teixeira AM,Chen RC,Wang L,Gao Y,Hahn KL,Krause DS
Thu Feb 14 00:00:00 EST 2013
Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival.
Blood
Holmfeldt P,Pardieck J,Saulsberry AC,Nandakumar SK,Finkelstein D,Gray JT,Persons DA,McKinney-Freeman S
Thu Oct 24 00:00:00 EDT 2013
Interferon-γ impairs proliferation of hematopoietic stem cells in mice.
Blood
de Bruin AM,Demirel Ö,Hooibrink B,Brandts CH,Nolte MA
Thu May 02 00:00:00 EDT 2013
Megakaryocytes promote murine osteoblastic HSC niche expansion and stem cell engraftment after radioablative conditioning.
Blood
Olson TS,Caselli A,Otsuru S,Hofmann TJ,Williams R,Paolucci P,Dominici M,Horwitz EM
Thu Jun 27 00:00:00 EDT 2013
Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
The Journal of clinical investigation
Martin H,Mali RS,Ma P,Chatterjee A,Ramdas B,Sims E,Munugalavadla V,Ghosh J,Mattingly RR,Visconte V,Tiu RV,Vlaar CP,Dharmawardhane S,Kapur R
Tue Oct 01 00:00:00 EDT 2013
Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells.
Proceedings of the National Academy of Sciences of the United States of America
Chan CK,Lindau P,Jiang W,Chen JY,Zhang LF,Chen CC,Seita J,Sahoo D,Kim JB,Lee A,Park S,Nag D,Gong Y,Kulkarni S,Luppen CA,Theologis AA,Wan DC,DeBoer A,Seo EY,Vincent-Tompkins JD,Loh K,Walmsley GG,Kraft DL,Wu JC,Longaker MT,Weissman IL
Tue Jul 30 00:00:00 EDT 2013
Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity.
Blood cancer journal
Pannucci NL,Li D,Sahay S,Thomas EK,Chen R,Tala I,Hu T,Ciccarelli BT,Megjugorac NJ,Adams Iii HC,Rodriguez PL,Fitzpatrick ER,Lagunoff D,Williams DA,Whitehead IP
Fri Aug 16 00:00:00 EDT 2013
Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.
Blood
Ross K,Sedello AK,Todd GP,Paszkowski-Rogacz M,Bird AW,Ding L,Grinenko T,Behrens K,Hubner N,Mann M,Waskow C,Stocking C,Buchholz F
Thu May 03 00:00:00 EDT 2012
Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.
Blood
Zhang Y,Yan X,Sashida G,Zhao X,Rao Y,Goyama S,Whitman SP,Zorko N,Bernot K,Conway RM,Witte D,Wang QF,Tenen DG,Xiao Z,Marcucci G,Mulloy JC,Grimes HL,Caligiuri MA,Huang G
Thu Aug 02 00:00:00 EDT 2012
Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration.
Blood
Kostyak JC,Naik MU,Naik UP
Thu Jan 19 00:00:00 EST 2012
KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.
Blood
Zhao L,Melenhorst JJ,Alemu L,Kirby M,Anderson S,Kench M,Hoogstraten-Miller S,Brinster L,Kamikubo Y,Gilliland DG,Liu PP
Thu Feb 09 00:00:00 EST 2012
Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation.
Blood
Cai M,Langer EM,Gill JG,Satpathy AT,Albring JC,KC W,Murphy TL,Murphy KM
Thu Jul 12 00:00:00 EDT 2012
Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion.
Blood
Tripodo C,Sangaletti S,Guarnotta C,Piccaluga PP,Cacciatore M,Giuliano M,Franco G,Chiodoni C,Sciandra M,Miotti S,Calvaruso G,Carè A,Florena AM,Scotlandi K,Orazi A,Pileri SA,Colombo MP
Thu Oct 25 00:00:00 EDT 2012
Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling.
Blood
Pulikkan JA,Madera D,Xue L,Bradley P,Landrette SF,Kuo YH,Abbas S,Zhu LJ,Valk P,Castilla LH
Thu Jul 26 00:00:00 EDT 2012
Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice.
Blood
Schepers K,Hsiao EC,Garg T,Scott MJ,Passegué E
Thu Oct 25 00:00:00 EDT 2012
PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.
Blood
van de Laar L,van den Bosch A,Boonstra A,Binda RS,Buitenhuis M,Janssen HL,Coffer PJ,Woltman AM
Thu Dec 13 00:00:00 EST 2012
14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells.
The Journal of clinical investigation
Jiang J,Balcerek J,Rozenova K,Cheng Y,Bersenev A,Wu C,Song Y,Tong W
Fri Jun 01 00:00:00 EDT 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
Mon Jan 16 00:00:00 EST 2012
Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells.
Proceedings of the National Academy of Sciences of the United States of America
Taniguchi Ishikawa E,Gonzalez-Nieto D,Ghiaur G,Dunn SK,Ficker AM,Murali B,Madhu M,Gutstein DE,Fishman GI,Barrio LC,Cancelas JA
Tue Jun 05 00:00:00 EDT 2012
Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.
Proceedings of the National Academy of Sciences of the United States of America
Guo S,Bai H,Megyola CM,Halene S,Krause DS,Scadden DT,Lu J
Tue Oct 09 00:00:00 EDT 2012
Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses.
Proceedings of the National Academy of Sciences of the United States of America
Purtha WE,Swiecki M,Colonna M,Diamond MS,Bhattacharya D
Tue Apr 10 00:00:00 EDT 2012
Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.
Proceedings of the National Academy of Sciences of the United States of America
Cunningham L,Finckbeiner S,Hyde RK,Southall N,Marugan J,Yedavalli VR,Dehdashti SJ,Reinhold WC,Alemu L,Zhao L,Yeh JR,Sood R,Pommier Y,Austin CP,Jeang KT,Zheng W,Liu P
Tue Sep 04 00:00:00 EDT 2012
NLRP3 inflammasome activity is negatively controlled by miR-223.
Journal of immunology (Baltimore, Md. : 1950)
Bauernfeind F,Rieger A,Schildberg FA,Knolle PA,Schmid-Burgk JL,Hornung V
Mon Oct 15 00:00:00 EDT 2012
TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms.
PloS one
Takaesu G,Inagaki M,Takubo K,Mishina Y,Hess PR,Dean GA,Yoshimura A,Matsumoto K,Suda T,Ninomiya-Tsuji J
Tue May 28 00:00:00 EDT 2013
Induction of histiocytic sarcoma in mouse skeletal muscle.
PloS one
Liu J,Hettmer S,Milsom MD,Hofmann I,Hua F,Miller C,Bronson RT,Wagers AJ
Thu Feb 07 00:00:00 EST 2013
The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression.
The Journal of biological chemistry
Haining EJ,Yang J,Bailey RL,Khan K,Collier R,Tsai S,Watson SP,Frampton J,Garcia P,Tomlinson MG
Fri Nov 16 00:00:00 EST 2012
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.
Cancer cell
Mazzieri R,Pucci F,Moi D,Zonari E,Ranghetti A,Berti A,Politi LS,Gentner B,Brown JL,Naldini L,De Palma M
Tue Apr 12 00:00:00 EDT 2011
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell
Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R
Tue Sep 13 00:00:00 EDT 2011
Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation.
Blood
Mazharian A,Ghevaert C,Zhang L,Massberg S,Watson SP
Thu May 12 00:00:00 EDT 2011
Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.
Blood
Maetzig T,Brugman MH,Bartels S,Heinz N,Kustikova OS,Modlich U,Li Z,Galla M,Schiedlmeier B,Schambach A,Baum C
Thu Mar 17 00:00:00 EDT 2011
Modulation of TGF-β signaling by endoglin in murine hemangioblast development and primitive hematopoiesis.
Blood
Zhang L,Magli A,Catanese J,Xu Z,Kyba M,Perlingeiro RC
Thu Jul 07 00:00:00 EDT 2011
Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.
Blood
Chen TH,Kambal A,Krysiak K,Walshauser MA,Raju G,Tibbitts JF,Walter MJ
Thu Feb 03 00:00:00 EST 2011
E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction.
Blood
Yang Q,Esplin B,Borghesi L
Thu Mar 31 00:00:00 EDT 2011
SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis.
Blood
Zhang L,Friedman AD
Thu Aug 25 00:00:00 EDT 2011
Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.
Blood
Chan G,Cheung LS,Yang W,Milyavsky M,Sanders AD,Gu S,Hong WX,Liu AX,Wang X,Barbara M,Sharma T,Gavin J,Kutok JL,Iscove NN,Shannon KM,Dick JE,Neel BG,Braun BS
Thu Apr 21 00:00:00 EDT 2011
Inhibitory effects of megakaryocytic cells in prostate cancer skeletal metastasis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Li X,Koh AJ,Wang Z,Soki FN,Park SI,Pienta KJ,McCauley LK
Sat Jan 01 00:00:00 EST 2011
Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events.
Stem cells (Dayton, Ohio)
Heffner GC,Clutter MR,Nolan GP,Weissman IL
Tue Nov 01 00:00:00 EDT 2011
Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells.
PloS one
Kostyak JC,Naik UP
Fri Jan 14 00:00:00 EST 2011
Differential Secondary Reconstitution of In Vivo-Selected Human SCID-Repopulating Cells in NOD/SCID versus NOD/SCID/γ chain Mice.
Bone marrow research
Cai S,Wang H,Bailey B,Hartwell JR,Silver JM,Juliar BE,Sinn AL,Baluyut AR,Pollok KE
Thu Nov 10 00:00:00 EST 2011
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.
Nature
Nakada D,Saunders TL,Morrison SJ
Thu Dec 02 00:00:00 EST 2010
A reprogrammable mouse strain from gene-targeted embryonic stem cells.
Nature methods
Stadtfeld M,Maherali N,Borkent M,Hochedlinger K
Fri Jan 01 00:00:00 EST 2010
Hematopoietic progenitor cell regulation by CD4+CD25+ T cells.
Blood
Urbieta M,Barao I,Jones M,Jurecic R,Panoskaltsis-Mortari A,Blazar BR,Murphy WJ,Levy RB
Thu Jun 10 00:00:00 EDT 2010
Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.
Blood
Chessa TA,Anderson KE,Hu Y,Xu Q,Rausch O,Stephens LR,Hawkins PT
Thu Dec 23 00:00:00 EST 2010
Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow.
Blood
Winter O,Moser K,Mohr E,Zotos D,Kaminski H,Szyska M,Roth K,Wong DM,Dame C,Tarlinton DM,Schulze H,MacLennan IC,Manz RA
Thu Sep 16 00:00:00 EDT 2010
Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow.
Blood
Winter O,Moser K,Mohr E,Zotos D,Kaminski H,Szyska M,Roth K,Wong DM,Dame C,Tarlinton DM,Schulze H,MacLennan IC,Manz RA
Thu Sep 16 00:00:00 EDT 2010
Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells.
Blood
Hosokawa K,Arai F,Yoshihara H,Iwasaki H,Nakamura Y,Gomei Y,Suda T
Thu Jul 29 00:00:00 EDT 2010
B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.
Blood
Kerns HM,Ryu BY,Stirling BV,Sather BD,Astrakhan A,Humblet-Baron S,Liggitt D,Rawlings DJ
Thu Mar 18 00:00:00 EDT 2010
Essential role for focal adhesion kinase in regulating stress hematopoiesis.
Blood
Vemula S,Ramdas B,Hanneman P,Martin J,Beggs HE,Kapur R
Thu Nov 18 00:00:00 EST 2010
Critical role of Src-Syk-PLC{gamma}2 signaling in megakaryocyte migration and thrombopoiesis.
Blood
Mazharian A,Thomas SG,Dhanjal TS,Buckley CD,Watson SP
Thu Aug 05 00:00:00 EDT 2010
Lineage-instructive function of C/EBPα in multipotent hematopoietic cells and early thymic progenitors.
Blood
Wölfler A,Danen-van Oorschot AA,Haanstra JR,Valkhof M,Bodner C,Vroegindeweij E,van Strien P,Novak A,Cupedo T,Touw IP
Thu Nov 18 00:00:00 EST 2010
The transcription factor Srf regulates hematopoietic stem cell adhesion.
Blood
Ragu C,Elain G,Mylonas E,Ottolenghi C,Cagnard N,Daegelen D,Passegué E,Vainchenker W,Bernard OA,Penard-Lacronique V
Thu Nov 25 00:00:00 EST 2010
Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation.
Blood
Starck J,Weiss-Gayet M,Gonnet C,Guyot B,Vicat JM,Morlé F
Thu Dec 02 00:00:00 EST 2010
JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia.
Blood
Li J,Spensberger D,Ahn JS,Anand S,Beer PA,Ghevaert C,Chen E,Forrai A,Scott LM,Ferreira R,Campbell PJ,Watson SP,Liu P,Erber WN,Huntly BJ,Ottersbach K,Green AR
Thu Sep 02 00:00:00 EDT 2010
Serum response factor is an essential transcription factor in megakaryocytic maturation.
Blood
Halene S,Gao Y,Hahn K,Massaro S,Italiano JE,Schulz V,Lin S,Kupfer GM,Krause DS
Thu Sep 16 00:00:00 EDT 2010
Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Naramura M,Nandwani N,Gu H,Band V,Band H
Tue Sep 14 00:00:00 EDT 2010
Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells.
Stem cells (Dayton, Ohio)
Zhou Z,French DL,Ma G,Eisenstein S,Chen Y,Divino CM,Keller G,Chen SH,Pan PY
Wed Mar 31 00:00:00 EDT 2010
MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.
Cell
Sarrazin S,Mossadegh-Keller N,Fukao T,Aziz A,Mourcin F,Vanhille L,Kelly Modis L,Kastner P,Chan S,Duprez E,Otto C,Sieweke MH
Thu Jul 23 00:00:00 EDT 2009
Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapy.
Blood
Laje P,Shang D,Cao W,Niiya M,Endo M,Radu A,DeRogatis N,Scheiflinger F,Zoltick PW,Flake AW,Zheng XL
Thu Mar 05 00:00:00 EST 2009
Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene.
Blood
Zhao H,Pestina TI,Nasimuzzaman M,Mehta P,Hargrove PW,Persons DA
Thu Jun 04 00:00:00 EDT 2009
Gfi1 integrates progenitor versus granulocytic transcriptional programming.
Blood
Horman SR,Velu CS,Chaubey A,Bourdeau T,Zhu J,Paul WE,Gebelein B,Grimes HL
Thu May 28 00:00:00 EDT 2009
High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle.
Blood
Tipping AJ,Pina C,Castor A,Hong D,Rodrigues NP,Lazzari L,May GE,Jacobsen SE,Enver T
Thu Mar 19 00:00:00 EDT 2009
Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis.
Blood
Lannutti BJ,Epp A,Roy J,Chen J,Josephson NC
Thu Feb 19 00:00:00 EST 2009
Role for MKL1 in megakaryocytic maturation.
Blood
Cheng EC,Luo Q,Bruscia EM,Renda MJ,Troy JA,Massaro SA,Tuck D,Schulz V,Mane SM,Berliner N,Sun Y,Morris SW,Qiu C,Krause DS
Thu Mar 19 00:00:00 EDT 2009
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.
Blood
Gekas C,Rhodes KE,Gereige LM,Helgadottir H,Ferrari R,Kurdistani SK,Montecino-Rodriguez E,Bassel-Duby R,Olson E,Krivtsov AV,Armstrong S,Orkin SH,Pellegrini M,Mikkola HK
Thu Apr 09 00:00:00 EDT 2009
Negative regulation of activated alpha-2 integrins during thrombopoiesis.
Blood
Zou Z,Schmaier AA,Cheng L,Mericko P,Dickeson SK,Stricker TP,Santoro SA,Kahn ML
Thu Jun 18 00:00:00 EDT 2009
Gfi1 regulates miR-21 and miR-196b to control myelopoiesis.
Blood
Velu CS,Baktula AM,Grimes HL
Thu May 07 00:00:00 EDT 2009
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.
The Journal of clinical investigation
Montini E,Cesana D,Schmidt M,Sanvito F,Bartholomae CC,Ranzani M,Benedicenti F,Sergi LS,Ambrosi A,Ponzoni M,Doglioni C,Di Serio C,von Kalle C,Naldini L
Wed Apr 01 00:00:00 EDT 2009
Niche recycling through division-independent egress of hematopoietic stem cells.
The Journal of experimental medicine
Bhattacharya D,Czechowicz A,Ooi AG,Rossi DJ,Bryder D,Weissman IL
Mon Nov 23 00:00:00 EST 2009
Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin.
Molecular therapy : the journal of the American Society of Gene Therapy
Pestina TI,Hargrove PW,Jay D,Gray JT,Boyd KM,Persons DA
Sun Feb 01 00:00:00 EST 2009
ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.
Proceedings of the National Academy of Sciences of the United States of America
XuFeng R,Boyer MJ,Shen H,Li Y,Yu H,Gao Y,Yang Q,Wang Q,Cheng T
Tue Oct 20 00:00:00 EDT 2009
The adhesion molecule esam1 is a novel hematopoietic stem cell marker.
Stem cells (Dayton, Ohio)
Ooi AG,Karsunky H,Majeti R,Butz S,Vestweber D,Ishida T,Quertermous T,Weissman IL,Forsberg EC
Sun Mar 01 00:00:00 EST 2009
The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.
Stem cells (Dayton, Ohio)
Ogaeri T,Eto K,Otsu M,Ema H,Nakauchi H
Fri May 01 00:00:00 EDT 2009
Thioredoxin-interacting protein regulates hematopoietic stem cell quiescence and mobilization under stress conditions.
Journal of immunology (Baltimore, Md. : 1950)
Jeong M,Piao ZH,Kim MS,Lee SH,Yun S,Sun HN,Yoon SR,Chung JW,Kim TD,Jeon JH,Lee J,Kim HN,Choi JY,Choi I
Sat Aug 15 00:00:00 EDT 2009
Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation.
Experimental hematology
Mazharian A,Watson SP,Séverin S
Thu Oct 01 00:00:00 EDT 2009
Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis.
PloS one
Aguilar S,Scotton CJ,McNulty K,Nye E,Stamp G,Laurent G,Bonnet D,Janes SM
Tue Nov 24 00:00:00 EST 2009
Nuclear factor of activated T cells (NFAT) mediates CD154 expression in megakaryocytes.
Blood
Crist SA,Sprague DL,Ratliff TL
Tue Apr 01 00:00:00 EDT 2008
Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.
PloS one
Kalaitzidis D,Neel BG
Tue Feb 10 00:00:00 EST 2009
PECAM-1: a multifaceted regulator of megakaryocytopoiesis.
Blood
Wu Y,Welte T,Michaud M,Madri JA
Wed Aug 01 00:00:00 EDT 2007
A role for thrombopoietin in hemangioblast development.
Stem cells (Dayton, Ohio)
Perlingeiro RC,Kyba M,Bodie S,Daley GQ
Fri Feb 27 00:00:00 EST 2004
Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.
Stem cells (Dayton, Ohio)
Metcalf D,Mifsud S,Di Rago L
Wed Mar 12 00:00:00 EST 2003
