Product References
Staphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acid.
Immunology
Miek L,Jordan PM,Günther K,Pace S,Beyer T,Kowalak D,Hoerr V,Löffler B,Tuchscherr L,Serhan CN,Gerstmeier J,Werz O
Sun May 01 00:00:00 EDT 2022
A homozygous hypomorphic BNIP1 variant causes an increase in autophagosomes and reduced autophagic flux and results in a spondylo-epiphyseal dysplasia.
Human mutation
Holling T,Bhavani GS,von Elsner L,Shah H,Kausthubham N,Bhattacharyya SS,Shukla A,Mortier GR,Schinke T,Danyukova T,Pohl S,Kutsche K,Girisha KM
Sun May 01 00:00:00 EDT 2022
Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization.
iScience
Cheng Y,Yu Y,Zhuang Q,Wang L,Zhan B,Du S,Liu Y,Huang J,Hao J,Zhu X
315-11 was used in Cell Culture to investigate helminths in rheumatoid arthritis treatment.
Fri Mar 18 00:00:00 EDT 2022
Osteonecrosis development by tooth extraction in zoledronate treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or antibiotics.
Scientific reports
Soma T,Iwasaki R,Sato Y,Kobayashi T,Ito E,Matsumoto T,Kimura A,Miyamoto K,Matsumoto M,Nakamura M,Morita M,Asoda S,Kawana H,Nakagawa T,Miyamoto T
Fri Jan 07 00:00:00 EST 2022
Sympathetic Neurostress Drives Osteoblastic Exosomal MiR-21 Transfer to Disrupt Bone Homeostasis and Promote Osteopenia.
Small methods
Hu CH,Sui BD,Liu J,Dang L,Chen J,Zheng CX,Shi S,Zhao N,Dang MY,He XN,Zhang LQ,Gao PP,Chen N,Kuang HJ,Chen K,Xu XL,Yu XR,Zhang G,Jin Y
315-11 was used in Cell Culture to state that sympathetic neurostress through the β1/2 -adrenergic receptor (β1/2-AR) signaling triggers the transcription response of a microRNA, miR-21, in osteoblasts, which is transferred to osteoclast progenitors via exosomes for dictating osteoclastogenesis.
Tue Mar 01 00:00:00 EST 2022
Aged skeletal stem cells generate an inflammatory degenerative niche.
Nature
Ambrosi TH,Marecic O,McArdle A,Sinha R,Gulati GS,Tong X,Wang Y,Steininger HM,Hoover MY,Koepke LS,Murphy MP,Sokol J,Seo EY,Tevlin R,Lopez M,Brewer RE,Mascharak S,Lu L,Ajanaku O,Conley SD,Seita J,Morri M,Neff NF,Sahoo D,Yang F,Weissman IL,Longaker MT,Chan CKF
Wed Sep 01 00:00:00 EDT 2021
Mechanical force-driven TNFα endocytosis governs stem cell homeostasis.
Bone research
Yu W,Chen C,Kou X,Sui B,Yu T,Liu D,Wang R,Wang J,Shi S
Fri Jan 01 00:00:00 EST 2021
Tumor- and osteoclast-derived NRP2 in prostate cancer bone metastases.
Bone research
Polavaram NS,Dutta S,Islam R,Bag AK,Roy S,Poitz D,Karnes J,Hofbauer LC,Kohli M,Costello BA,Jimenez R,Batra SK,Teply BA,Muders MH,Datta K
Fri May 14 00:00:00 EDT 2021
Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss.
Experimental & molecular medicine
Lee SY,Park KH,Lee G,Kim SJ,Song WH,Kwon SH,Koh JT,Huh YH,Ryu JH
Thu Apr 01 00:00:00 EDT 2021
Pathogenic variants in GNPTAB and GNPTG encoding distinct subunits of GlcNAc-1-phosphotransferase differentially impact bone resorption in patients with mucolipidosis type II and III.
Genetics in medicine : official journal of the American College of Medical Genetics
Di Lorenzo G,Westermann LM,Yorgan TA,Stürznickel J,Ludwig NF,Ammer LS,Baranowsky A,Ahmadi S,Pourbarkhordariesfandabadi E,Breyer SR,Board TN,Foster A,Mercer J,Tylee K,Velho RV,Schweizer M,Renné T,Braulke T,Randon DN,Sperb-Ludwig F,de Camargo Pinto LL,Moreno CA,Cavalcanti DP,Amling M,Kutsche K,Winter D,Muschol NM,Schwartz IVD,Rolvien T,Danyukova T,Schinke T,Pohl S
Wed Dec 01 00:00:00 EST 2021
The calcium channel TRPV6 is a novel regulator of RANKL-induced osteoclastic differentiation and bone absorption activity through the IGF-PI3K-AKT pathway.
Cell proliferation
Ma J,Zhu L,Zhou Z,Song T,Yang L,Yan X,Chen A,Ye TW
Fri Jan 01 00:00:00 EST 2021
Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Hendrickx G,Fischer V,Liedert A,von Kroge S,Haffner-Luntzer M,Brylka L,Pawlus E,Schweizer M,Yorgan T,Baranowsky A,Rolvien T,Neven M,Schumacher U,Beech DJ,Amling M,Ignatius A,Schinke T
Mon Feb 01 00:00:00 EST 2021
Dental pulp-derived stem cells inhibit osteoclast differentiation by secreting osteoprotegerin and deactivating AKT signalling in myeloid cells.
Journal of cellular and molecular medicine
Kanji S,Sarkar R,Pramanik A,Kshirsagar S,Greene CJ,Das H
Mon Mar 01 00:00:00 EST 2021
Dental pulp-derived stem cells inhibit osteoclast differentiation by secreting osteoprotegerin and deactivating AKT signalling in myeloid cells.
Journal of cellular and molecular medicine
Kanji S,Sarkar R,Pramanik A,Kshirsagar S,Greene CJ,Das H
Mon Mar 01 00:00:00 EST 2021
Sphingosylphosphorylcholine blocks ovariectomy-induced bone loss by suppressing Ca2+ /calmodulin-mediated osteoclast differentiation.
Journal of cellular and molecular medicine
Lee HY,Cho KM,Kim MK,Lee M,Kim H,Choi CY,Kim KK,Park JS,Kim HH,Bae YS
Fri Jan 01 00:00:00 EST 2021
N-[2-(4-benzoyl-1-piperazinyl)phenyl]-2-(4-chlorophenoxy) acetamide is a novel inhibitor of resorptive bone loss in mice.
Journal of cellular and molecular medicine
Chen Z,Cho E,Ding M,Seong J,Che X,Lee S,Park BJ,Choi JY,Lee TH
Mon Feb 01 00:00:00 EST 2021
Hepatocyte growth factor overexpression promotes osteoclastogenesis and exacerbates bone loss in CIA mice.
Journal of orthopaedic translation
Huang C,Zheng Y,Bai J,Shi C,Shi X,Shan H,Zhou X
315-11 was used in Cell Culture to study effect of hepatocyte growth factor (HGF) on bone metabolism in rheumatoid arthritis (RA).
Mon Mar 01 00:00:00 EST 2021
A functional motif of long noncoding RNA Nron against osteoporosis.
Nature communications
Jin F,Li J,Zhang YB,Liu X,Cai M,Liu M,Li M,Ma C,Yue R,Zhu Y,Lai R,Wang Z,Ji X,Wei H,Dong J,Liu Z,Wang Y,Sun Y,Wang X
315-11 was used in In vitro experiments to reveal the long noncoding RNA, Nron, as a suppressor of bone resorption.
Thu Jun 03 00:00:00 EDT 2021
Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice.
Scientific reports
Westermann LM,Baranowsky A,Di Lorenzo G,Danyukova T,Soul J,Schwartz JM,Hendrickx G,Amling M,Rose-John S,Garbers C,Schinke T,Pohl S
Thu Feb 11 00:00:00 EST 2021
Effect of resolvin D5 on T cell differentiation and osteoclastogenesis analyzed by lipid mediator profiling in the experimental arthritis.
Scientific reports
Yamada H,Saegusa J,Sendo S,Ueda Y,Okano T,Shinohara M,Morinobu A
Fri Aug 27 00:00:00 EDT 2021
Extracellular Vesicles from Child Gut Microbiota Enter into Bone to Preserve Bone Mass and Strength.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu JH,Chen CY,Liu ZZ,Luo ZW,Rao SS,Jin L,Wan TF,Yue T,Tan YJ,Yin H,Yang F,Huang FY,Guo J,Wang YY,Xia K,Cao J,Wang ZX,Hong CG,Luo MJ,Hu XK,Liu YW,Du W,Luo J,Hu Y,Zhang Y,Huang J,Li HM,Wu B,Liu HM,Chen TH,Qian YX,Li YY,Feng SK,Chen Y,Qi LY,Xu R,Tang SY,Xie H
Sat May 01 00:00:00 EDT 2021
TRPV6 is a potential regulator of bone resorption in bone loss induced by estrogen deficiency.
iScience
Ma J,Lu J,Zhou Z,Lu N,He J,Zhu L,Ye T
Fri Nov 19 00:00:00 EST 2021
The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.
Immunity
Friščić J,Böttcher M,Reinwald C,Bruns H,Wirth B,Popp SJ,Walker KI,Ackermann JA,Chen X,Turner J,Zhu H,Seyler L,Euler M,Kirchner P,Krüger R,Ekici AB,Major T,Aust O,Weidner D,Fischer A,Andes FT,Stanojevic Z,Trajkovic V,Herrmann M,Korb-Pap A,Wank I,Hess A,Winter J,Wixler V,Distler J,Steiner G,Kiener HP,Frey B,Kling L,Raza K,Frey S,Kleyer A,Bäuerle T,Hughes TR,Grüneboom A,Steffen U,Krönke G,Croft AP,Filer A,Köhl J,Klein K,Buckley CD,Schett G,Mougiakakos D,Hoffmann MH
315-11 was used in Cell Culture to define the molecular and cellular mechanisms of this inflammation-mediated tissue priming and suggest possibilities for therapeutic intervention abrogating tissue priming without immunosuppression.
Tue May 11 00:00:00 EDT 2021
Extracellular vesicles derived from the periodontal pathogen Filifactor alocis induce systemic bone loss through Toll-like receptor 2.
Journal of extracellular vesicles
Kim HY,Song MK,Gho YS,Kim HH,Choi BK
Fri Oct 01 00:00:00 EDT 2021
Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone.
Cell death & disease
He Y,Cheng D,Lian C,Liu Y,Luo W,Wang Y,Ma C,Wu Q,Tian P,He D,Jia Z,Lv X,Zhang X,Pan Z,Lu J,Xiao Y,Zhang P,Liang Y,Yang Q,Hu G
Thu Sep 23 00:00:00 EDT 2021
Myeloid Lineage Ablation of Phlpp1 Regulates M-CSF Signaling and Tempers Bone Resorption in Female Mice.
International journal of molecular sciences
Karkache IY,Damodaran JR,Molstad DHH,Mansky KC,Bradley EW
315-11 was used in Cell Culture to show that Phlpp1 represses osteoclastogenesis and controls responses to M-CSF.
Wed Sep 08 00:00:00 EDT 2021
Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer.
Nature communications
Wu K,Feng J,Lyu F,Xing F,Sharma S,Liu Y,Wu SY,Zhao D,Tyagi A,Deshpande RP,Pei X,Ruiz MG,Takahashi H,Tsuzuki S,Kimura T,Mo YY,Shiozawa Y,Singh R,Watabe K
Tue Aug 31 00:00:00 EDT 2021
Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis.
Nature communications
Deng C,Zhang Q,He P,Zhou B,He K,Sun X,Lei G,Gong T,Zhang Z
Mon Apr 12 00:00:00 EDT 2021
Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1-targeting miRNA-92a-1-5p.
Journal of extracellular vesicles
Yu L,Sui B,Fan W,Lei L,Zhou L,Yang L,Diao Y,Zhang Y,Li Z,Liu J,Hao X
Fri Jan 01 00:00:00 EST 2021
Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.
Frontiers in pharmacology
Sun J,Chen W,Li S,Yang S,Zhang Y,Hu X,Qiu H,Wu J,Xu S,Chu T
315-11 was used in In vitro experiments to investigate molecular mechanisms of RANKL induction of osteoclastogenesis.
Sat Oct 16 00:00:00 EDT 2021
Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin.
The Journal of clinical investigation
Andreev D,Liu M,Weidner D,Kachler K,Faas M,Grüneboom A,Schlötzer-Schrehardt U,Muñoz LE,Steffen U,Grötsch B,Killy B,Krönke G,Luebke AM,Niemeier A,Wehrhan F,Lang R,Schett G,Bozec A
Tue Sep 01 00:00:00 EDT 2020
Ophiopogonin D promotes bone regeneration by stimulating CD31hi EMCNhi vessel formation.
Cell proliferation
Yang M,Li CJ,Xiao Y,Guo Q,Huang Y,Su T,Luo XH,Jiang TJ
Sun Mar 01 00:00:00 EST 2020
PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation.
Journal of molecular cell biology
Zhao X,Cui P,Hu G,Wang C,Jiang L,Zhao J,Xu J,Zhang X
315-11 was used in Cell Culture to investigate the role of PIP5k1β deletion on mouse models.
Wed Jan 22 00:00:00 EST 2020
Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jeong E,Kim J,Go M,Lee SY
Tue Sep 01 00:00:00 EDT 2020
Nuciferine prevents bone loss by disrupting multinucleated osteoclast formation and promoting type H vessel formation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Song C,Cao J,Lei Y,Chi H,Kong P,Chen G,Yu T,Li J,Kumar Prajapati R,Xia J,Yan J
Sun Mar 01 00:00:00 EST 2020
Erythropoietin signaling in osteoblasts is required for normal bone formation and for bone loss during erythropoietin-stimulated erythropoiesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Suresh S,Lee J,Noguchi CT
Tue Sep 01 00:00:00 EDT 2020
Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β-catenin signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zheng W,Ding B,Li X,Liu D,Yokota H,Zhang P
Sat Feb 01 00:00:00 EST 2020
Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β-catenin signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zheng W,Ding B,Li X,Liu D,Yokota H,Zhang P
Sat Feb 01 00:00:00 EST 2020
Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li B,Lee WC,Song C,Ye L,Abel ED,Long F
Sat Aug 01 00:00:00 EDT 2020
Siglec-15 on Osteoclasts Is Crucial for Bone Erosion in Serum-Transfer Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Korn MA,Schmitt H,Angermüller S,Chambers D,Seeling M,Lux UT,Brey S,Royzman D,Brückner C,Popp V,Percivalle E,Bäuerle T,Zinser E,Winkler TH,Steinkasserer A,Nimmerjahn F,Nitschke L
Sun Nov 15 00:00:00 EST 2020
Sotrastaurin, a PKC inhibitor, attenuates RANKL-induced bone resorption and attenuates osteochondral pathologies associated with the development of OA.
Journal of cellular and molecular medicine
Pang C,Wen L,Qin H,Zhu B,Lu X,Luo S
Sat Aug 01 00:00:00 EDT 2020
Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
Journal of cellular and molecular medicine
Wang J,Guan H,Liu H,Lei Z,Kang H,Guo Q,Dong Y,Liu H,Sun Y,Fang Z,Li F
Sat Feb 01 00:00:00 EST 2020
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk.
Nature communications
Wang L,You X,Lotinun S,Zhang L,Wu N,Zou W
Wed Jan 15 00:00:00 EST 2020
Relevance of Caspase-1 and Nlrp3 Inflammasome on Inflammatory Bone Resorption in A Murine Model of Periodontitis.
Scientific reports
Rocha FRG,Delitto AE,de Souza JAC,González-Maldonado LA,Wallet SM,Rossa Junior C
Fri May 08 00:00:00 EDT 2020
Microbe-Dependent Exacerbated Alveolar Bone Destruction in Heterozygous Cherubism Mice.
JBMR plus
Kittaka M,Yoshimoto T,Schlosser C,Kajiya M,Kurihara H,Reichenberger EJ,Ueki Y
Mon Jun 01 00:00:00 EDT 2020
Niclosamide and its derivative DK-520 inhibit RANKL-induced osteoclastogenesis.
FEBS open bio
Jiao Y,Chen C,Hu X,Feng X,Shi Z,Cao J,Li Q,Zhu Y
Sat Aug 01 00:00:00 EDT 2020
Long non-coding RNA MIR22HG promotes osteogenic differentiation of bone marrow mesenchymal stem cells via PTEN/ AKT pathway.
Cell death & disease
Jin C,Jia L,Tang Z,Zheng Y
Thu Jul 30 00:00:00 EDT 2020
Krüppel-like factor 3 inhibition by mutated lncRNA Reg1cp results in human high bone mass syndrome.
The Journal of experimental medicine
Yang M,Guo Q,Peng H,Xiao YZ,Xiao Y,Huang Y,Li CJ,Su T,Zhang YL,Lei MX,Chen HL,Jiang TJ,Luo XH
Mon Aug 05 00:00:00 EDT 2019
Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice.
Bone research
Lee SY,Park KH,Yu HG,Kook E,Song WH,Lee G,Koh JT,Shin HI,Choi JY,Huh YH,Ryu JH
Thu Oct 01 00:00:00 EDT 2020
Erythropoietin modulates bone marrow stromal cell differentiation.
Bone research
Suresh S,de Castro LF,Dey S,Robey PG,Noguchi CT
Wed Sep 30 00:00:00 EDT 2020
Fluorine-contained hydroxyapatite suppresses bone resorption through inhibiting osteoclasts differentiation and function in vitro and in vivo.
Cell proliferation
Liu S,Zhou H,Liu H,Ji H,Fei W,Luo E
Wed May 01 00:00:00 EDT 2019
Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis.
Journal of cellular and molecular medicine
Jiang M,Yan Y,Yang K,Liu Z,Qi J,Zhou H,Qian N,Zhou Q,Wang T,Xu X,Xiao X,Deng L
Fri Feb 01 00:00:00 EST 2019
Isorhamnetin attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through modulating reactive oxygen species homeostasis.
Journal of cellular and molecular medicine
Zhou F,Mei J,Yuan K,Han X,Qiao H,Tang T
Sat Jun 01 00:00:00 EDT 2019
Isorhamnetin attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through modulating reactive oxygen species homeostasis.
Journal of cellular and molecular medicine
Zhou F,Mei J,Yuan K,Han X,Qiao H,Tang T
Sat Jun 01 00:00:00 EDT 2019
FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts.
Journal of cellular biochemistry
Battaglino RA,Jha P,Sultana F,Liu W,Morse LR
315-11 was used in Cell Culture to study how Snx10 regulates vasicular formation and trafficking in osteoclasts to indicate that the Snx10 and FKBP12 partners are involved in the regulation of endosome/lysosome homeostasis via the synthesis.
Thu Aug 01 00:00:00 EDT 2019
Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis.
Frontiers in immunology
Dong L,Wu J,Chen K,Xie J,Wang Y,Li D,Liu Y,Yin A,Zhao Y,Han Y,Zhou J,Zhang L,Chen Z,Zuo D
315-11 was used in Cell Culture to investigate the role of mannan-binding lectin on murine adjuvant-induced arthritis.
Wed Oct 28 00:00:00 EDT 2020
G-protein Gα13 functions as a cytoskeletal and mitochondrial regulator to restrain osteoclast function.
Scientific reports
Nakano S,Inoue K,Xu C,Deng Z,Syrovatkina V,Vitone G,Zhao L,Huang XY,Zhao B
Tue Mar 12 00:00:00 EDT 2019
Despite Genetic Iron Overload, Hfe-Hemochromatosis Mice Do Not Show Bone Loss.
JBMR plus
Wagner A,Alan B,Yilmaz D,Ahmad M,Liu P,Tangudu NK,Tuckermann JP,Vujic Spasic M
Sun Sep 01 00:00:00 EDT 2019
Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment.
Communications biology
Ochiai N,Nakachi Y,Yokoo T,Ichihara T,Eriksson T,Yonemoto Y,Kato T,Ogata H,Fujimoto N,Kobayashi Y,Udagawa N,Kaku S,Ueki T,Okazaki Y,Takahashi N,Suda T
Thu Apr 16 00:00:00 EDT 2020
TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion.
Communications biology
Yamamoto M,Abe C,Wakinaga S,Sakane K,Yumiketa Y,Taguchi Y,Matsumura T,Ishikawa K,Fujimoto J,Semba K,Miyauchi M,Akiyama T,Inoue JI
Mon Apr 20 00:00:00 EDT 2020
A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment.
Scientific reports
Kang J,Choi YJ,Seo BY,Jo U,Park SI,Kim YH,Park KH
315-11 was used in Cell Culture to study the efficacy of fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors (TKIs) in the bone microenvironment where breast cancer cells most frequently metastasize.
Wed Jun 19 00:00:00 EDT 2019
A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment.
Scientific reports
Kang J,Choi YJ,Seo BY,Jo U,Park SI,Kim YH,Park KH
315-11 was used in Cell Culture to study the efficacy of fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors (TKIs) in the bone microenvironment where breast cancer cells most frequently metastasize.
Wed Jun 19 00:00:00 EDT 2019
The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis.
Nature communications
Doonan J,Tarafdar A,Pineda MA,Lumb FE,Crowe J,Khan AM,Hoskisson PA,Harnett MM,Harnett W
Fri Apr 05 00:00:00 EDT 2019
Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD-signaling pathway.
The Journal of biological chemistry
Omi M,Kaartinen V,Mishina Y
Fri Nov 22 00:00:00 EST 2019
Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling.
Experimental & molecular medicine
Baek JM,Cheon YH,Kwak SC,Jun HY,Yoon KH,Lee MS,Kim JY
Fri Apr 27 00:00:00 EDT 2018
Plastin 3 influences bone homeostasis through regulation of osteoclast activity.
Human molecular genetics
Neugebauer J,Heilig J,Hosseinibarkooie S,Ross BC,Mendoza-Ferreira N,Nolte F,Peters M,Hölker I,Hupperich K,Tschanz T,Grysko V,Zaucke F,Niehoff A,Wirth B
315-11 was used in In vitro experiments to show that regulation of osteoclastogenesis and bone remodeling via the PLS3-NKRF-NFκB-NFATC1 axis unveils a novel possibility to counteract osteoporosis.
Sat Dec 15 00:00:00 EST 2018
Xenograft of Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly Differentiating into Osteocytes and Reducing Osteoclast Activity Reverses Osteoporosis in Ovariectomized Rats.
Cell transplantation
Fu YS,Lu CH,Chu KA,Yeh CC,Chiang TL,Ko TL,Chiu MM,Chen CF
315-11 was used in Cell Culture to study the effects of human umbilical cord-derived mesenchymal stem cells (HUMSCs) in Wharton's jelly on ovariectomy (OVX)-induced osteoporosis by using in vitro and in vivo experiments.
Mon Jan 01 00:00:00 EST 2018
FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-κB Activation and CXCL10 Expression.
BioMed research international
Lv ZT,Liang S,Chen K,Zhang JM,Cheng P,Guo JC,Yang Q,Zhou CH,Liao H,Chen AM
315-11 was used in In vitro experiments to investigate the role and mechanisms of FNDC4 in osteoclast differentiation.
Mon Jan 14 00:00:00 EST 2019
Isosteviol Derivative Inhibits Osteoclast Differentiation and Ameliorates Ovariectomy-Induced Osteoporosis.
Scientific reports
Tzeng HE,Huang PH,Tsai CH,Tsay GJ,Lee YJ,Huang TJ,Lin TH,Chiu YM,Wu YY
Wed Jul 25 00:00:00 EDT 2018
Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts.
Blood cancer journal
Faict S,Muller J,De Veirman K,De Bruyne E,Maes K,Vrancken L,Heusschen R,De Raeve H,Schots R,Vanderkerken K,Caers J,Menu E
Thu Nov 08 00:00:00 EST 2018
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.
Nature communications
Stegen S,Stockmans I,Moermans K,Thienpont B,Maxwell PH,Carmeliet P,Carmeliet G
Mon Jul 02 00:00:00 EDT 2018
Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment.
Scientific reports
Matsumoto N,Sekiya M,Tohyama K,Ishiyama-Matsuura E,Sun-Wada GH,Wada Y,Futai M,Nakanishi-Matsui M
Mon Apr 30 00:00:00 EDT 2018
p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget's disease-like bone phenotypes in mice.
The Journal of biological chemistry
Zach F,Polzer F,Mueller A,Gessner A
Fri Jun 15 00:00:00 EDT 2018
Schlafen2 mutation in mice causes an osteopetrotic phenotype due to a decrease in the number of osteoclast progenitors.
Scientific reports
Omar I,Guterman-Ram G,Rahat D,Tabach Y,Berger M,Levaot N
Wed Aug 29 00:00:00 EDT 2018
Artemether attenuates LPS-induced inflammatory bone loss by inhibiting osteoclastogenesis and bone resorption via suppression of MAPK signaling pathway.
Cell death & disease
Wu H,Hu B,Zhou X,Zhou C,Meng J,Yang Y,Zhao X,Shi Z,Yan S
Tue May 01 00:00:00 EDT 2018
Visual Osteoclast Fusion via A Fluorescence Method.
Scientific reports
Li B,Yu F,Wu F,Wang K,Lou F,Zhang D,Liao X,Yin B,Wang C,Ye L
Thu Jul 05 00:00:00 EDT 2018
In vitro Osteoclastogenesis Assays Using Primary Mouse Bone Marrow Cells.
Bio-protocol
Zhuang X,Hu G
315-11 was used in Cell Culture to describe an osteoclastogenesis protocol which can be used to evaluate the effect of different factors such as cytokines, small molecular chemicals and conditioned medium from cell culture, on osteoclast differentiation using primary murine bone marrow cells.
Tue Jun 05 00:00:00 EDT 2018
Resveratrol prevents osteoporosis by upregulating FoxO1 transcriptional activity.
International journal of molecular medicine
Feng YL,Jiang XT,Ma FF,Han J,Tang XL
315-11 was used in Cell Culture to indicate that RES has a significant bone protective effect by antagonizing oxidative stress to suppress osteoclast activity, function and formation both in vivo and in vitro.
Mon Jan 01 00:00:00 EST 2018
Pharmacologically Inactive Bisphosphonates as an Alternative Strategy for Targeting Osteoclasts: In Vivo Assessment of 5-Fluorodeoxyuridine-Alendronate in a Preclinical Model of Breast Cancer Bone Metastases.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Schem C,Tower RJ,Kneissl P,Rambow AC,Campbell GM,Desel C,Damm T,Heilmann T,Fuchs S,Zuhayra M,Trauzold A,Glüer CC,Schott S,Tiwari S
Wed Mar 01 00:00:00 EST 2017
Baicalin positively regulates osteoclast function by activating MAPK/Mitf signalling.
Journal of cellular and molecular medicine
Lu L,Rao L,Jia H,Chen J,Lu X,Yang G,Li Q,Lee KKH,Yang L
Sat Jul 01 00:00:00 EDT 2017
Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption.
FEBS open bio
Watanabe K,Tominari T,Hirata M,Matsumoto C,Hirata J,Murphy G,Nagase H,Miyaura C,Inada M
Tue Aug 01 00:00:00 EDT 2017
Symmetrical retrograde actin flow in the actin fusion structure is involved in osteoclast fusion.
Biology open
Takito J,Otsuka H,Inoue S,Kawashima T,Nakamura M
315-11 was used in Cell Culture to investigate zipper-like structure formation in osteoclast podosomes.
Sat Jul 15 00:00:00 EDT 2017
DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation.
Nature communications
Kim HS,Nam ST,Mun SH,Lee SK,Kim HW,Park YH,Kim B,Won KJ,Kim HR,Park YM,Kim HS,Beaven MA,Kim YM,Choi WS
Wed Nov 15 00:00:00 EST 2017
Transglutaminase 2 regulates osteoclast differentiation via a Blimp1-dependent pathway.
Scientific reports
Kim WS,Kim H,Jeong EM,Kim HJ,Lee ZH,Kim IG,Kim HH
Wed Sep 06 00:00:00 EDT 2017
Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I.
Scientific reports
Azario I,Pievani A,Del Priore F,Antolini L,Santi L,Corsi A,Cardinale L,Sawamoto K,Kubaski F,Gentner B,Bernardo ME,Valsecchi MG,Riminucci M,Tomatsu S,Aiuti A,Biondi A,Serafini M
Fri Aug 25 00:00:00 EDT 2017
Dectin-1 signaling inhibits osteoclastogenesis via IL-33-induced inhibition of NFATc1.
Oncotarget
Zhu X,Zhao Y,Jiang Y,Qin T,Chen J,Chu X,Yi Q,Gao S,Wang S
315-11 was used in Cell Culture to study the underlying mechanisms of how the agonist of dectin-1 inhibirs osteoclastogenesis and determine that curdlan potently inhibited RANKL-induced osteoclast differentiation and the resultant bone resorption.
Tue Aug 08 00:00:00 EDT 2017
Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life.
Nature communications
Elias S,Morgan MA,Bikoff EK,Robertson EJ
Mon Nov 20 00:00:00 EST 2017
FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2.
Scientific reports
Park MY,Kim HS,Lee M,Park B,Lee HY,Cho EB,Seong JY,Bae YS
Tue Nov 14 00:00:00 EST 2017
DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.
Cell
Herrtwich L,Nanda I,Evangelou K,Nikolova T,Horn V,Erny D,Stefanowski J,Rogell L,Klein C,Gharun K,Follo M,Seidl M,Kremer B,Münke N,Senges J,Fliegauf M,Aschman T,Pfeifer D,Sarrazin S,Sieweke MH,Wagner D,Dierks C,Haaf T,Ness T,Zaiss MM,Voll RE,Deshmukh SD,Prinz M,Goldmann T,Hölscher C,Hauser AE,Lopez-Contreras AJ,Grün D,Gorgoulis V,Diefenbach A,Henneke P,Triantafyllopoulou A
Thu Nov 17 00:00:00 EST 2016
Deletion of FGFR3 in Osteoclast Lineage Cells Results in Increased Bone Mass in Mice by Inhibiting Osteoclastic Bone Resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Su N,Li X,Tang Y,Yang J,Wen X,Guo J,Tang J,Du X,Chen L
Thu Sep 01 00:00:00 EDT 2016
Lysyl oxidase propeptide stimulates osteoblast and osteoclast differentiation and enhances PC3 and DU145 prostate cancer cell effects on bone in vivo.
Journal of cell communication and signaling
Alsulaiman M,Bais MV,Trackman PC
315-11 was used in Cell Culture to study the effect of LOX-PP on bone marroe cell proliferation and differentiation towards osteoblast or osteoclasts, and LOX-PP modulation of prostate cancer cell conditioned media-induced alterations of proliferation and differentiation of bone marrow cells in vitro.
Tue Mar 01 00:00:00 EST 2016
The Nuclear Receptor AhR Controls Bone Homeostasis by Regulating Osteoclast Differentiation via the RANK/c-Fos Signaling Axis.
Journal of immunology (Baltimore, Md. : 1950)
Izawa T,Arakaki R,Mori H,Tsunematsu T,Kudo Y,Tanaka E,Ishimaru N
Thu Dec 15 00:00:00 EST 2016
Elevated Response to Type I IFN Enhances RANKL-Mediated Osteoclastogenesis in Usp18-Knockout Mice.
Journal of immunology (Baltimore, Md. : 1950)
Yim HY,Park C,Lee YD,Arimoto K,Jeon R,Baek SH,Zhang DE,Kim HH,Kim KI
Sun May 01 00:00:00 EDT 2016
Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21.
Journal of immunology (Baltimore, Md. : 1950)
Prokopec KE,Georgoudaki AM,Sohn S,Wermeling F,Grönlund H,Lindh E,Carroll MC,Karlsson MC
Thu Sep 15 00:00:00 EDT 2016
Desferrioxamine reduces ultrahigh-molecular-weight polyethylene-induced osteolysis by restraining inflammatory osteoclastogenesis via heme oxygenase-1.
Cell death & disease
Kang H,Yan Y,Jia P,Yang K,Guo C,Chen H,Qi J,Qian N,Xu X,Wang F,Li C,Guo L,Deng L
Thu Oct 27 00:00:00 EDT 2016
Th2 and eosinophil responses suppress inflammatory arthritis.
Nature communications
Chen Z,Andreev D,Oeser K,Krljanac B,Hueber A,Kleyer A,Voehringer D,Schett G,Bozec A
Tue Jun 07 00:00:00 EDT 2016
Inhibition of Osteoclast Differentiation and Bone Resorption by Bisphosphonate-conjugated Gold Nanoparticles.
Scientific reports
Lee D,Heo DN,Kim HJ,Ko WK,Lee SJ,Heo M,Bang JB,Lee JB,Hwang DS,Do SH,Kwon IK
Thu Jun 02 00:00:00 EDT 2016
High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6.
Oncotarget
Chen GL,Luo Y,Eriksson D,Meng X,Qian C,Bäuerle T,Chen XX,Schett G,Bozec A
315-11 was used in Cell Culture to examine the mechanisms by which a high-fat diet promotes melanoma growth in the bone marrow.
Tue May 03 00:00:00 EDT 2016
ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β.
Scientific reports
Robaszkiewicz A,Qu C,Wisnik E,Ploszaj T,Mirsaidi A,Kunze FA,Richards PJ,Cinelli P,Mbalaviele G,Hottiger MO
Wed Feb 17 00:00:00 EST 2016
Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass.
Scientific reports
Hirozane T,Tohmonda T,Yoda M,Shimoda M,Kanai Y,Matsumoto M,Morioka H,Nakamura M,Horiuchi K
Wed Sep 28 00:00:00 EDT 2016
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation.
Nature communications
Li D,Liu J,Guo B,Liang C,Dang L,Lu C,He X,Cheung HY,Xu L,Lu C,He B,Liu B,Shaikh AB,Li F,Wang L,Yang Z,Au DW,Peng S,Zhang Z,Zhang BT,Pan X,Qian A,Shang P,Xiao L,Jiang B,Wong CK,Xu J,Bian Z,Liang Z,Guo DA,Zhu H,Tan W,Lu A,Zhang G
Mon Mar 07 00:00:00 EST 2016
MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells.
Nature communications
Yu J,Lei R,Zhuang X,Li X,Li G,Lev S,Segura MF,Zhang X,Hu G
Tue Dec 20 00:00:00 EST 2016
NADPH oxidase gp91phox contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1.
Scientific reports
Kang IS,Kim C
Tue Nov 29 00:00:00 EST 2016
Inhibition of Complement Retards Ankylosing Spondylitis Progression.
Scientific reports
Yang C,Ding P,Wang Q,Zhang L,Zhang X,Zhao J,Xu E,Wang N,Chen J,Yang G,Hu W,Zhou X
Tue Oct 04 00:00:00 EDT 2016
Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors.
Scientific reports
Shi C,Iura A,Terajima M,Liu F,Lyons K,Pan H,Zhang H,Yamauchi M,Mishina Y,Sun H
Wed Apr 06 00:00:00 EDT 2016
A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke.
Scientific reports
Kurinami H,Shimamura M,Nakagami H,Shimizu H,Koriyama H,Kawano T,Wakayama K,Mochizuki H,Rakugi H,Morishita R
Tue Nov 29 00:00:00 EST 2016
Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.
Scientific reports
Watari K,Shibata T,Nabeshima H,Shinoda A,Fukunaga Y,Kawahara A,Karasuyama K,Fukushi J,Iwamoto Y,Kuwano M,Ono M
Mon Jan 18 00:00:00 EST 2016
A Dual Target-directed Agent against Interleukin-6 Receptor and Tumor Necrosis Factor α ameliorates experimental arthritis.
Scientific reports
Kim Y,Yi H,Jung H,Rim YA,Park N,Kim J,Jung SM,Park SH,Park YW,Ju JH
Thu Feb 04 00:00:00 EST 2016
Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation.
Scientific reports
Park SJ,Huh JE,Shin J,Park DR,Ko R,Jin GR,Seo DH,Kim HS,Shin HI,Oh GT,Kim HS,Lee SY
Wed May 18 00:00:00 EDT 2016
Ablation of Y1 receptor impairs osteoclast bone-resorbing activity.
Scientific reports
Sousa DM,Conceição F,Silva DI,Leitão L,Neto E,Alves CJ,Alencastre IS,Herzog H,Aguiar P,Lamghari M
Tue Sep 20 00:00:00 EDT 2016
IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis.
The Journal of clinical investigation
Tohmonda T,Yoda M,Iwawaki T,Matsumoto M,Nakamura M,Mikoshiba K,Toyama Y,Horiuchi K
Mon Aug 03 00:00:00 EDT 2015
MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation.
The Journal of clinical investigation
Li CJ,Cheng P,Liang MK,Chen YS,Lu Q,Wang JY,Xia ZY,Zhou HD,Cao X,Xie H,Liao EY,Luo XH
Wed Apr 01 00:00:00 EDT 2015
Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease.
The Journal of clinical investigation
Ersek A,Xu K,Antonopoulos A,Butters TD,Santo AE,Vattakuzhi Y,Williams LM,Goudevenou K,Danks L,Freidin A,Spanoudakis E,Parry S,Papaioannou M,Hatjiharissi E,Chaidos A,Alonzi DS,Twigg G,Hu M,Dwek RA,Haslam SM,Roberts I,Dell A,Rahemtulla A,Horwood NJ,Karadimitris A
Mon Jun 01 00:00:00 EDT 2015
Serum amyloid A inhibits RANKL-induced osteoclast formation.
Experimental & molecular medicine
Oh E,Lee HY,Kim HJ,Park YJ,Seo JK,Park JS,Bae YS
Fri Nov 13 00:00:00 EST 2015
Serum amyloid A inhibits RANKL-induced osteoclast formation.
Experimental & molecular medicine
Oh E,Lee HY,Kim HJ,Park YJ,Seo JK,Park JS,Bae YS
Fri Nov 13 00:00:00 EST 2015
Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells.
Journal of immunology (Baltimore, Md. : 1950)
Jeschke A,Catala-Lehnen P,Sieber S,Bickert T,Schweizer M,Koehne T,Wintges K,Marshall RP,Mautner A,Duchstein L,Otto B,Horst AK,Amling M,Kreienkamp HJ,Schinke T
Thu Oct 15 00:00:00 EDT 2015
PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk.
Journal of immunology (Baltimore, Md. : 1950)
Drobek A,Kralova J,Skopcova T,Kucova M,Novák P,Angelisová P,Otahal P,Alberich-Jorda M,Brdicka T
Thu Oct 01 00:00:00 EDT 2015
FOXO1 mediates RANKL-induced osteoclast formation and activity.
Journal of immunology (Baltimore, Md. : 1950)
Wang Y,Dong G,Jeon HH,Elazizi M,La LB,Hameedaldeen A,Xiao E,Tian C,Alsadun S,Choi Y,Graves DT
Sun Mar 15 00:00:00 EDT 2015
Adipose-Derived Mesenchymal Stem Cells Prevent Systemic Bone Loss in Collagen-Induced Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Garimella MG,Kour S,Piprode V,Mittal M,Kumar A,Rani L,Pote ST,Mishra GC,Chattopadhyay N,Wani MR
Tue Dec 01 00:00:00 EST 2015
Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.
Stem cell reports
Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F
Tue Oct 13 00:00:00 EDT 2015
Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force.
Scientific reports
Guo T,Zhang L,Konermann A,Zhou H,Jin F,Liu W
Mon Jan 26 00:00:00 EST 2015
Interleukin-1 receptor-associated kinase-4 (IRAK4) promotes inflammatory osteolysis by activating osteoclasts and inhibiting formation of foreign body giant cells.
The Journal of biological chemistry
Katsuyama E,Miyamoto H,Kobayashi T,Sato Y,Hao W,Kanagawa H,Fujie A,Tando T,Watanabe R,Morita M,Miyamoto K,Niki Y,Morioka H,Matsumoto M,Toyama Y,Miyamoto T
Fri Jan 09 00:00:00 EST 2015
Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss.
Scientific reports
Zhang Y,Guan H,Li J,Fang Z,Chen W,Li F
Fri Sep 04 00:00:00 EDT 2015
Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss.
Scientific reports
Zhang Y,Guan H,Li J,Fang Z,Chen W,Li F
Fri Sep 04 00:00:00 EDT 2015
Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.
Nature communications
Yanagihara T,Sanematsu F,Sato T,Uruno T,Duan X,Tomino T,Harada Y,Watanabe M,Wang Y,Tanaka Y,Nakanishi Y,Suyama M,Yoshinori F
Wed Nov 04 00:00:00 EST 2015
Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors.
The Journal of biological chemistry
Pontejo SM,Alejo A,Alcami A
Fri Jun 26 00:00:00 EDT 2015
Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity.
Nature
van de Pavert SA,Ferreira M,Domingues RG,Ribeiro H,Molenaar R,Moreira-Santos L,Almeida FF,Ibiza S,Barbosa I,Goverse G,Labão-Almeida C,Godinho-Silva C,Konijn T,Schooneman D,O'Toole T,Mizee MR,Habani Y,Haak E,Santori FR,Littman DR,Schulte-Merker S,Dzierzak E,Simas JP,Mebius RE,Veiga-Fernandes H
Thu Apr 03 00:00:00 EDT 2014
RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis.
The Journal of clinical investigation
Li S,Miller CH,Giannopoulou E,Hu X,Ivashkiv LB,Zhao B
Sat Nov 01 00:00:00 EDT 2014
OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice.
Proceedings of the National Academy of Sciences of the United States of America
Shimamura M,Nakagami H,Osako MK,Kurinami H,Koriyama H,Zhengda P,Tomioka H,Tenma A,Wakayama K,Morishita R
Tue Jun 03 00:00:00 EDT 2014
Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
He Q,Yang X,Gong Y,Kovalenko D,Canalis E,Rosen CJ,Friesel RE
Tue Dec 09 00:00:00 EST 2014
A novel role for interferon regulatory factor 1 (IRF1) in regulation of bone metabolism.
Journal of cellular and molecular medicine
Salem S,Gao C,Li A,Wang H,Nguyen-Yamamoto L,Goltzman D,Henderson JE,Gros P
Fri Aug 01 00:00:00 EDT 2014
Self in vivo production of a synthetic biological drug CTLA4Ig using a minicircle vector.
Scientific reports
Rim YA,Yi H,Kim Y,Park N,Jung H,Kim J,Jung SM,Park SH,Ju JH
Thu Nov 06 00:00:00 EST 2014
The dectin 1 agonist curdlan regulates osteoclastogenesis by inhibiting nuclear factor of activated T cells cytoplasmic 1 (NFATc1) through Syk kinase.
The Journal of biological chemistry
Yamasaki T,Ariyoshi W,Okinaga T,Adachi Y,Hosokawa R,Mochizuki S,Sakurai K,Nishihara T
Fri Jul 04 00:00:00 EDT 2014
The actin binding protein adseverin regulates osteoclastogenesis.
PloS one
Hassanpour S,Jiang H,Wang Y,Kuiper JW,Glogauer M
315-11 was used in Cell Culture to investigate the role of adseverin in osteoclastogenesis regulation.
Wed Jun 10 00:00:00 EDT 2015
High bone mass in mice lacking Cx37 because of defective osteoclast differentiation.
The Journal of biological chemistry
Pacheco-Costa R,Hassan I,Reginato RD,Davis HM,Bruzzaniti A,Allen MR,Plotkin LI
Fri Mar 21 00:00:00 EDT 2014
Adult T-cell leukemia cells overexpress Wnt5a and promote osteoclast differentiation.
Blood
Bellon M,Ko NL,Lee MJ,Yao Y,Waldmann TA,Trepel JB,Nicot C
Thu Jun 20 00:00:00 EDT 2013
The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2.
The Journal of experimental medicine
Zou W,Greenblatt MB,Brady N,Lotinun S,Zhai B,de Rivera H,Singh A,Sun J,Gygi SP,Baron R,Glimcher LH,Jones DC
Mon Aug 26 00:00:00 EDT 2013
Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin.
The Journal of cell biology
Albers J,Keller J,Baranowsky A,Beil FT,Catala-Lehnen P,Schulze J,Amling M,Schinke T
Mon Feb 18 00:00:00 EST 2013
A small shared epitope-mimetic compound potently accelerates osteoclast-mediated bone damage in autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Fu J,Ling S,Liu Y,Yang J,Naveh S,Hannah M,Gilon C,Zhang Y,Holoshitz J
Sun Sep 01 00:00:00 EDT 2013
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R
Tue Jan 01 00:00:00 EST 2013
The effect of alendronate on the expression of important cell factors in osteoclasts.
Molecular medicine reports
Zhang Q,Liu M,Zhou Y,Liu W,Shen J,Shen Y,Liu L
315-11 was used in Cell Culture to study the change to mature osteoclasts using sRANKL induced RAW 264.7 cells and study the effects of of alendronate (ALN) on critical cell factors in osteoclasts.
Tue Oct 01 00:00:00 EDT 2013
Osteoblast-targeted overexpression of TAZ increases bone mass in vivo.
PloS one
Yang JY,Cho SW,An JH,Jung JY,Kim SW,Kim SY,Kim JE,Shin CS
Tue Aug 13 00:00:00 EDT 2013
Genetic deletion of catalytic subunits of AMP-activated protein kinase increases osteoclasts and reduces bone mass in young adult mice.
The Journal of biological chemistry
Kang H,Viollet B,Wu D
Fri Apr 26 00:00:00 EDT 2013
Osteoprotection by semaphorin 3A.
Nature
Hayashi M,Nakashima T,Taniguchi M,Kodama T,Kumanogoh A,Takayanagi H
Thu May 03 00:00:00 EDT 2012
Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.
Blood
Pulvino M,Liang Y,Oleksyn D,DeRan M,Van Pelt E,Shapiro J,Sanz I,Chen L,Zhao J
Thu Aug 23 00:00:00 EDT 2012
TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.
The Journal of experimental medicine
Zhao B,Grimes SN,Li S,Hu X,Ivashkiv LB
Mon Feb 13 00:00:00 EST 2012
Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development.
Proceedings of the National Academy of Sciences of the United States of America
Tsuji-Takechi K,Negishi-Koga T,Sumiya E,Kukita A,Kato S,Maeda T,Pandolfi PP,Moriyama K,Takayanagi H
Tue Feb 14 00:00:00 EST 2012
Decreased osteoclastogenesis in serotonin-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America
Chabbi-Achengli Y,Coudert AE,Callebert J,Geoffroy V,Côté F,Collet C,de Vernejoul MC
Tue Feb 14 00:00:00 EST 2012
Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival.
The Journal of cell biology
Kim HJ,Prasad V,Hyung SW,Lee ZH,Lee SW,Bhargava A,Pearce D,Lee Y,Kim HH
Mon Dec 24 00:00:00 EST 2012
Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion.
The Journal of cell biology
Oikawa T,Oyama M,Kozuka-Hata H,Uehara S,Udagawa N,Saya H,Matsuo K
Mon May 14 00:00:00 EDT 2012
Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion.
The Journal of cell biology
Oikawa T,Oyama M,Kozuka-Hata H,Uehara S,Udagawa N,Saya H,Matsuo K
Mon May 14 00:00:00 EDT 2012
Phospholipase Cγ2 is required for basal but not oestrogen deficiency-induced bone resorption.
European journal of clinical investigation
Kertész Z,Gyori D,Körmendi S,Fekete T,Kis-Tóth K,Jakus Z,Schett G,Rajnavölgyi E,Dobó-Nagy C,Mócsai A
Sun Jan 01 00:00:00 EST 2012
Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Swanson CD,Akama-Garren EH,Stein EA,Petralia JD,Ruiz PJ,Edalati A,Lindstrom TM,Robinson WH
Sun Apr 01 00:00:00 EDT 2012
5-Lipoxygenase mediates RANKL-induced osteoclast formation via the cysteinyl leukotriene receptor 1.
Journal of immunology (Baltimore, Md. : 1950)
Lee JM,Park H,Noh AL,Kang JH,Chen L,Zheng T,Lee J,Ji SY,Jang CY,Shin CS,Ha H,Lee ZH,Park HY,Lee DS,Yim M
Sat Dec 01 00:00:00 EST 2012
Retinoic acid attenuates rheumatoid inflammation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Kwok SK,Park MK,Cho ML,Oh HJ,Park EM,Lee DG,Lee J,Kim HY,Park SH
Sun Jul 15 00:00:00 EDT 2012
Conditional inactivation of Blimp1 in adult mice promotes increased bone mass.
The Journal of biological chemistry
Miyauchi Y,Miyamoto H,Yoshida S,Mori T,Kanagawa H,Katsuyama E,Fujie A,Hao W,Hoshi H,Miyamoto K,Sato Y,Kobayashi T,Akiyama H,Morioka H,Matsumoto M,Toyama Y,Miyamoto T
Fri Aug 17 00:00:00 EDT 2012
Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis.
The Journal of biological chemistry
Toro EJ,Zuo J,Ostrov DA,Catalfamo D,Bradaschia-Correa V,Arana-Chavez V,Caridad AR,Neubert JK,Wronski TJ,Wallet SM,Holliday LS
Fri May 18 00:00:00 EDT 2012
Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer.
Oncoimmunology
Zhao E,Wang L,Dai J,Kryczek I,Wei S,Vatan L,Altuwaijri S,Sparwasser T,Wang G,Keller ET,Zou W
Thu Mar 01 00:00:00 EST 2012
Cofilin activation during podosome belt formation in osteoclasts.
PloS one
Blangy A,Touaitahuata H,Cres G,Pawlak G
Tue May 07 00:00:00 EDT 2013
Inositol hexakisphosphate inhibits osteoclastogenesis on RAW 264.7 cells and human primary osteoclasts.
PloS one
Arriero Mdel M,Ramis JM,Perelló J,Monjo M
Mon Feb 11 00:00:00 EST 2013
Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.
The Journal of biological chemistry
Mieczkowska A,Baslé MF,Chappard D,Mabilleau G
Fri Jul 06 00:00:00 EDT 2012
c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions.
PloS one
He Y,Rhodes SD,Chen S,Wu X,Yuan J,Yang X,Jiang L,Li X,Takahashi N,Xu M,Mohammad KS,Guise TA,Yang FC
Mon Apr 22 00:00:00 EDT 2013
Low-dose, ionizing radiation and age-related changes in skeletal microarchitecture.
Journal of aging research
Alwood JS,Kumar A,Tran LH,Wang A,Limoli CL,Globus RK
Thu Aug 23 00:00:00 EDT 2012
Transgenic mice for a tamoxifen-induced, conditional expression of the Cre recombinase in osteoclasts.
PloS one
Sanchez-Fernandez MA,Sbacchi S,Correa-Tapia M,Naumann R,Klemm J,Chambon P,Al-Robaiy S,Blessing M,Hoflack B
Wed Sep 19 00:00:00 EDT 2012
Identification of NOG as a specific breast cancer bone metastasis-supporting gene.
The Journal of biological chemistry
Tarragona M,Pavlovic M,Arnal-Estapé A,Urosevic J,Morales M,Guiu M,Planet E,González-Suárez E,Gomis RR
Fri Jun 15 00:00:00 EDT 2012
Precursors linked via the zipper-like structure or the filopodium during the secondary fusion of osteoclasts.
Communicative & integrative biology
Takito J,Nakamura M
Sat Sep 01 00:00:00 EDT 2012
Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells.
PloS one
Zhuang J,Zhang J,Lwin ST,Edwards JR,Edwards CM,Mundy GR,Yang X
Thu Mar 14 00:00:00 EDT 2013
Decreased autocrine EGFR signaling in metastatic breast cancer cells inhibits tumor growth in bone and mammary fat pad.
PloS one
Nickerson NK,Mohammad KS,Gilmore JL,Crismore E,Bruzzaniti A,Guise TA,Foley J
Mon Jun 04 00:00:00 EDT 2012
Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment.
Blood
Singbrant S,Russell MR,Jovic T,Liddicoat B,Izon DJ,Purton LE,Sims NA,Martin TJ,Sankaran VG,Walkley CR
Thu May 26 00:00:00 EDT 2011
Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.
Blood
Zimmer SN,Zhou Q,Zhou T,Cheng Z,Abboud-Werner SL,Horn D,Lecocke M,White R,Krivtsov AV,Armstrong SA,Kung AL,Livingston DM,Rebel VI
Thu Jul 07 00:00:00 EDT 2011
Sbds is required for Rac2-mediated monocyte migration and signaling downstream of RANK during osteoclastogenesis.
Blood
Leung R,Cuddy K,Wang Y,Rommens J,Glogauer M
Thu Feb 10 00:00:00 EST 2011
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption.
The Journal of cell biology
Schmidt S,Nakchbandi I,Ruppert R,Kawelke N,Hess MW,Pfaller K,Jurdic P,Fässler R,Moser M
Mon Mar 07 00:00:00 EST 2011
Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signaling.
Molecular and cellular biology
Kim NS,Kim HT,Kwon MC,Choi SW,Kim YY,Yoon KJ,Koo BK,Kong MP,Shin J,Cho Y,Kong YY
315-11 was used in Immunohistochemistry-immunofluorescence to demonstrate that nuclear retention of Id2 due to RANK signaling plays a decisive role in the survival and differentiation of MECs during mammary gland development.
Thu Dec 01 00:00:00 EST 2011
Antibody-mediated "universal" osteoclast targeting platform using calcitonin as a model drug.
Pharmaceutical research
Newa M,Bhandari KH,Tang L,Kalvapalle R,Suresh M,Doschak MR
Sun May 01 00:00:00 EDT 2011
Erk1 positively regulates osteoclast differentiation and bone resorptive activity.
PloS one
He Y,Staser K,Rhodes SD,Liu Y,Wu X,Park SJ,Yuan J,Yang X,Li X,Jiang L,Chen S,Yang FC
Thu Mar 01 00:00:00 EST 2012
The critical role of IL-34 in osteoclastogenesis.
PloS one
Chen Z,Buki K,Vääräniemi J,Gu G,Väänänen HK
Fri Apr 08 00:00:00 EDT 2011
The transient receptor potential ion channel TRPV6 is expressed at low levels in osteoblasts and has little role in osteoblast calcium uptake.
PloS one
Little R,Muimo R,Robson L,Harris K,Grabowski PS
Fri May 11 00:00:00 EDT 2012
Internal control genes for quantitative RT-PCR expression analysis in mouse osteoblasts, osteoclasts and macrophages.
BMC research notes
Stephens AS,Stephens SR,Morrison NA
Fri Oct 14 00:00:00 EDT 2011
The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis.
PloS one
Liu S,Madiai F,Hackshaw KV,Allen CE,Carl J,Huschart E,Karanfilov C,Litsky A,Hickey CJ,Marcucci G,Huja S,Agarwal S,Yu J,Caligiuri MA,Wu LC
Thu Mar 03 00:00:00 EST 2011
Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation.
The Journal of clinical investigation
Nishikawa K,Nakashima T,Takeda S,Isogai M,Hamada M,Kimura A,Kodama T,Yamaguchi A,Owen MJ,Takahashi S,Takayanagi H
Fri Oct 01 00:00:00 EDT 2010
The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.
The Journal of experimental medicine
Miyauchi Y,Ninomiya K,Miyamoto H,Sakamoto A,Iwasaki R,Hoshi H,Miyamoto K,Hao W,Yoshida S,Morioka H,Chiba K,Kato S,Tokuhisa T,Saitou M,Toyama Y,Suda T,Miyamoto T
Mon Apr 12 00:00:00 EDT 2010
Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo.
The Journal of experimental medicine
Ishii M,Kikuta J,Shimazu Y,Meier-Schellersheim M,Germain RN
Mon Dec 20 00:00:00 EST 2010
Important roles of PI3Kgamma in osteoclastogenesis and bone homeostasis.
Proceedings of the National Academy of Sciences of the United States of America
Kang H,Chang W,Hurley M,Vignery A,Wu D
Tue Jul 20 00:00:00 EDT 2010
c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis.
Arthritis research & therapy
Paniagua RT,Chang A,Mariano MM,Stein EA,Wang Q,Lindstrom TM,Sharpe O,Roscow C,Ho PP,Lee DM,Robinson WH
Fri Aug 13 00:00:00 EDT 2010
CXC chemokine ligand 2 induced by receptor activator of NF-kappa B ligand enhances osteoclastogenesis.
Journal of immunology (Baltimore, Md. : 1950)
Ha J,Choi HS,Lee Y,Kwon HJ,Song YW,Kim HH
Sat May 01 00:00:00 EDT 2010
Bone is not essential for osteoclast activation.
PloS one
Fuller K,Ross JL,Szewczyk KA,Moss R,Chambers TJ
Fri Sep 17 00:00:00 EDT 2010
Determination of the differentiation capacities of murines' primary mononucleated cells and MC3T3-E1 cells.
Cancer cell international
Yazid MD,Ariffin SHZ,Senafi S,Razak MA,Wahab RMA
Thu Oct 28 00:00:00 EDT 2010
Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6.
PloS one
Pirih FQ,Michalski MN,Cho SW,Koh AJ,Berry JE,Ghaname E,Kamarajan P,Bonnelye E,Ross CW,Kapila YL,Jurdic P,McCauley LK
Wed Oct 27 00:00:00 EDT 2010
Rabconnectin-3 is a functional regulator of mammalian Notch signaling.
The Journal of biological chemistry
Sethi N,Yan Y,Quek D,Schupbach T,Kang Y
Fri Nov 05 00:00:00 EDT 2010
Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation.
PloS one
Chun JN,Choi B,Lee KW,Lee DJ,Kang DH,Lee JY,Song IS,Kim HI,Lee SH,Kim HS,Lee NK,Lee SY,Lee KJ,Kim J,Kang SW
Tue Mar 23 00:00:00 EDT 2010
Deficiency of chemokine receptor CCR1 causes osteopenia due to impaired functions of osteoclasts and osteoblasts.
The Journal of biological chemistry
Hoshino A,Iimura T,Ueha S,Hanada S,Maruoka Y,Mayahara M,Suzuki K,Imai T,Ito M,Manome Y,Yasuhara M,Kirino T,Yamaguchi A,Matsushima K,Yamamoto K
Fri Sep 10 00:00:00 EDT 2010
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis.
Nature
Ishii M,Egen JG,Klauschen F,Meier-Schellersheim M,Saeki Y,Vacher J,Proia RL,Germain RN
Thu Mar 26 00:00:00 EDT 2009
Central control of fever and female body temperature by RANKL/RANK.
Nature
Hanada R,Leibbrandt A,Hanada T,Kitaoka S,Furuyashiki T,Fujihara H,Trichereau J,Paolino M,Qadri F,Plehm R,Klaere S,Komnenovic V,Mimata H,Yoshimatsu H,Takahashi N,von Haeseler A,Bader M,Kilic SS,Ueta Y,Pifl C,Narumiya S,Penninger JM
Thu Nov 26 00:00:00 EST 2009
PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts.
Blood
Hikata T,Takaishi H,Takito J,Hakozaki A,Furukawa M,Uchikawa S,Kimura T,Okada Y,Matsumoto M,Yoshimura A,Nishimura R,Reddy SV,Asahara H,Toyama Y
Thu Mar 05 00:00:00 EST 2009
Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12.
Proceedings of the National Academy of Sciences of the United States of America
Inui M,Kikuchi Y,Aoki N,Endo S,Maeda T,Sugahara-Tobinai A,Fujimura S,Nakamura A,Kumanogoh A,Colonna M,Takai T
Tue Mar 24 00:00:00 EDT 2009
A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss.
Proceedings of the National Academy of Sciences of the United States of America
Hikiji H,Ishii S,Yokomizo T,Takato T,Shimizu T
Tue Dec 15 00:00:00 EST 2009
The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Whyte LS,Ryberg E,Sims NA,Ridge SA,Mackie K,Greasley PJ,Ross RA,Rogers MJ
Tue Sep 22 00:00:00 EDT 2009
Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.
The Journal of cell biology
Mizoguchi T,Muto A,Udagawa N,Arai A,Yamashita T,Hosoya A,Ninomiya T,Nakamura H,Yamamoto Y,Kinugawa S,Nakamura M,Nakamichi Y,Kobayashi Y,Nagasawa S,Oda K,Tanaka H,Tagaya M,Penninger JM,Ito M,Takahashi N
Mon Feb 23 00:00:00 EST 2009
SLP-76 couples Syk to the osteoclast cytoskeleton.
Journal of immunology (Baltimore, Md. : 1950)
Reeve JL,Zou W,Liu Y,Maltzman JS,Ross FP,Teitelbaum SL
Sat Aug 01 00:00:00 EDT 2009
Cross-presentation by osteoclasts induces FoxP3 in CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kiesel JR,Buchwald ZS,Aurora R
Fri May 01 00:00:00 EDT 2009
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.
PloS one
Chan AS,Jensen KK,Skokos D,Doty S,Lederman HK,Kaplan RN,Rafii S,Rivella S,Lyden D
Tue Nov 24 00:00:00 EST 2009
Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone.
The Journal of biological chemistry
Lu X,Kang Y
Fri Oct 16 00:00:00 EDT 2009
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism.
The Journal of clinical investigation
Aliprantis AO,Ueki Y,Sulyanto R,Park A,Sigrist KS,Sharma SM,Ostrowski MC,Olsen BR,Glimcher LH
Sat Nov 01 00:00:00 EDT 2008
Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone.
Proceedings of the National Academy of Sciences of the United States of America
Yano A,Tsutsumi S,Soga S,Lee MJ,Trepel J,Osada H,Neckers L
Tue Oct 07 00:00:00 EDT 2008
RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Yang S,Li YP
Mon Jan 01 00:00:00 EST 2007
EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases.
The Journal of biological chemistry
Zhu J,Jia X,Xiao G,Kang Y,Partridge NC,Qin L
Fri Sep 14 00:00:00 EDT 2007
Interaction of Fas ligand and Fas expressed on osteoclast precursors increases osteoclastogenesis.
Journal of immunology (Baltimore, Md. : 1950)
Park H,Jung YK,Park OJ,Lee YJ,Choi JY,Choi Y
Thu Dec 01 00:00:00 EST 2005
