Product References
Yes-associated protein regulates glutamate homeostasis through promoting the expression of excitatory amino acid transporter-2 in astrocytes via β-catenin signaling.
Glia
Xu X,Wang J,Du S,Shen X,Lian J,Zhou J,Wang M,Feng W,Lv Z,Zhu J,Jin L,Sun H,Wu L,Wang X,Qiu H,Wang W,Teng H,Wang Y,Huang Z
315-20 was used in In vitro experiments to identify an unrecognized role of YAP signaling in the regulation of glutamate homeostasis through the β-catenin/EAAT2 pathway in astrocytes, which may provide novel insights into the pathogenesis of brain diseases that closely related to the dysfunction or dysregulation of EAAT2, and promote the development of clinical strategy.
Mon May 01 00:00:00 EDT 2023
Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β.
PLoS biology
Shi XC,Xia B,Zhang JF,Zhang RX,Zhang DY,Liu H,Xie BC,Wang YL,Wu JW
315-20 was used in In vivo experiments to investigate differentially expressed genes and optineurin in muscle.
Fri Apr 01 00:00:00 EDT 2022
Canonical Wnt signaling induces focal adhesion and Integrin beta-1 endocytosis.
iScience
Tejeda-Muñoz N,Morselli M,Moriyama Y,Sheladiya P,Pellegrini M,De Robertis EM
315-20 was used in Cell Culture to understand how Wnt signalling causes endocytotic mechanisms involving the reduction of focal adhesion proteins and integrin beta 1 from the cell surface.
Fri Apr 15 00:00:00 EDT 2022
Canonical Wnt signaling induces focal adhesion and Integrin beta-1 endocytosis.
iScience
Tejeda-Muñoz N,Morselli M,Moriyama Y,Sheladiya P,Pellegrini M,De Robertis EM
315-20 was used in Cell Culture to understand how Wnt signalling causes endocytotic mechanisms involving the reduction of focal adhesion proteins and integrin beta 1 from the cell surface.
Fri Apr 15 00:00:00 EDT 2022
Canonical Wnt signaling induces focal adhesion and Integrin beta-1 endocytosis.
iScience
Tejeda-Muñoz N,Morselli M,Moriyama Y,Sheladiya P,Pellegrini M,De Robertis EM
315-20 was used in Cell Culture to understand how Wnt signalling causes endocytotic mechanisms involving the reduction of focal adhesion proteins and integrin beta 1 from the cell surface.
Fri Apr 15 00:00:00 EDT 2022
Role of the WNT/β-catenin/ZKSCAN3 Pathway in Regulating Chromosomal Instability in Colon Cancer Cell lines and Tissues.
International journal of molecular sciences
Cho YE,Kim JH,Che YH,Kim YJ,Sung JY,Kim YW,Choe BG,Lee S,Park JH
315-20 was used in Cell Culture to conclude that ZKSCAN3 could be responsible for WNT/β-catenin-induced chromosomal instability in colon cancer cells through the suppression of MAD2L2 expression.
Thu Aug 18 00:00:00 EDT 2022
Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo.
The Journal of biological chemistry
Zhang Y,Wang Y,Zheng G,Liu Y,Li J,Huang H,Xu C,Zeng Y,Zhang X,Qin J,Dai C,Hambrock HO,Hartmann U,Feng B,Mak KK,Liu Y,Lan HY,Huang Y,Zheng ZH,Xia Y
315-20 was used in In vitro experiments to conclude that FSTL1 is a novel extracellular enhancer of the Wnt/β-catenin pathway in obstructed mouse kidneys.
Fri Jul 01 00:00:00 EDT 2022
Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection.
Immunity
Zhu B,Wu Y,Huang S,Zhang R,Son YM,Li C,Cheon IS,Gao X,Wang M,Chen Y,Zhou X,Nguyen Q,Phan AT,Behl S,Taketo MM,Mack M,Shapiro VS,Zeng H,Ebihara H,Mullon JJ,Edell ES,Reisenauer JS,Demirel N,Kern RM,Chakraborty R,Cui W,Kaplan MH,Zhou X,Goldrath AW,Sun J
Tue Jun 08 00:00:00 EDT 2021
Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection.
Immunity
Zhu B,Wu Y,Huang S,Zhang R,Son YM,Li C,Cheon IS,Gao X,Wang M,Chen Y,Zhou X,Nguyen Q,Phan AT,Behl S,Taketo MM,Mack M,Shapiro VS,Zeng H,Ebihara H,Mullon JJ,Edell ES,Reisenauer JS,Demirel N,Kern RM,Chakraborty R,Cui W,Kaplan MH,Zhou X,Goldrath AW,Sun J
Tue Jun 08 00:00:00 EDT 2021
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.
Cell stem cell
Breunig M,Merkle J,Wagner M,Melzer MK,Barth TFE,Engleitner T,Krumm J,Wiedenmann S,Cohrs CM,Perkhofer L,Jain G,Krüger J,Hermann PC,Schmid M,Madácsy T,Varga Á,Griger J,Azoitei N,Müller M,Wessely O,Robey PG,Heller S,Dantes Z,Reichert M,Günes C,Bolenz C,Kuhn F,Maléth J,Speier S,Liebau S,Sipos B,Kuster B,Seufferlein T,Rad R,Meier M,Hohwieler M,Kleger A
315-20 was used in Cell Culture to show that PDLOs enable in vitro and in vivo studies of pancreatic plasticity, dysplasia, and cancer formation from a genetically defined background.
Thu Jun 03 00:00:00 EDT 2021
Oligodendroglial ring finger protein Rnf43 is an essential injury-specific regulator of oligodendrocyte maturation.
Neuron
Niu J,Yu G,Wang X,Xia W,Wang Y,Hoi KK,Mei F,Xiao L,Chan JR,Fancy SPJ
Wed Oct 06 00:00:00 EDT 2021
Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors.
Proceedings of the National Academy of Sciences of the United States of America
Helfinger V,Freiherr von Gall F,Henke N,Kunze MM,Schmid T,Rezende F,Heidler J,Wittig I,Radeke HH,Marschall V,Anderson K,Shah AM,Fulda S,Brüne B,Brandes RP,Schröder K
Tue Mar 16 00:00:00 EDT 2021
Parsing β-catenin's cell adhesion and Wnt signaling functions in malignant mammary tumor progression.
Proceedings of the National Academy of Sciences of the United States of America
Buechel D,Sugiyama N,Rubinstein N,Saxena M,Kalathur RKR,Lüönd F,Vafaizadeh V,Valenta T,Hausmann G,Cantù C,Basler K,Christofori G
Tue Aug 24 00:00:00 EDT 2021
Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance.
Progress in neurobiology
Guérit S,Fidan E,Macas J,Czupalla CJ,Figueiredo R,Vijikumar A,Yalcin BH,Thom S,Winter P,Gerhardt H,Devraj K,Liebner S
315-20 was used in Cell Culture to show by conditionally knocking out the evenness interrupted (Evi) gene in astrocytes (EviΔAC) that astrocytic Wnt release is crucial for BBB and NVU integrity.
Thu Apr 01 00:00:00 EDT 2021
Mechanosensitive miR-100 coordinates TGFβ and Wnt signaling in osteocytes during fluid shear stress.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dole NS,Yoon J,Monteiro DA,Yang J,Mazur CM,Kaya S,Belair CD,Alliston T
Fri Oct 01 00:00:00 EDT 2021
RAB11A-mediated YAP localization to adherens and tight junctions is essential for colonic epithelial integrity.
The Journal of biological chemistry
Goswami S,Balasubramanian I,D'Agostino L,Bandyopadhyay S,Patel R,Avasthi S,Yu S,Goldenring JR,Bonder EM,Gao N
Thu Jul 01 00:00:00 EDT 2021
Multiplexed single-cell analysis of organoid signaling networks.
Nature protocols
Sufi J,Qin X,Rodriguez FC,Bu YJ,Vlckova P,Zapatero MR,Nitz M,Tape CJ
Fri Oct 01 00:00:00 EDT 2021
Deleterious Effects of SARS-CoV-2 Infection on Human Pancreatic Cells.
Frontiers in cellular and infection microbiology
Shaharuddin SH,Wang V,Santos RS,Gross A,Wang Y,Jawanda H,Zhang Y,Hasan W,Garcia G,Arumugaswami V,Sareen D
Thu Jul 22 00:00:00 EDT 2021
Differentiation of human pluripotent stem cells into pancreatic duct-like organoids.
STAR protocols
Breunig M,Merkle J,Melzer MK,Heller S,Seufferlein T,Meier M,Hohwieler M,Kleger A
315-20 was used in In vitro experiments to describe a scalable in vitro differentiation protocol to guide human pluripotent stem cells stepwise into pancreatic duct-like organoids.
Fri Dec 17 00:00:00 EST 2021
Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation.
Communications biology
Heller S,Li Z,Lin Q,Geusz R,Breunig M,Hohwieler M,Zhang X,Nair GG,Seufferlein T,Hebrok M,Sander M,Julier C,Kleger A,Costa IG
Wed Nov 17 00:00:00 EST 2021
Extracts from Pulsatilla patens target cancer-related signaling pathways in HeLa cells.
Scientific reports
Łaska G,Maciejewska-Turska M,Sieniawska E,Świątek Ł,Pasco DS,Balachandran P
Thu May 20 00:00:00 EDT 2021
mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways.
Cell reports
Li K,Wu H,Wang A,Charron J,Mishina Y,Habib SL,Liu H,Li B
Tue May 04 00:00:00 EDT 2021
Oviduct epithelial cells constitute two developmentally distinct lineages that are spatially separated along the distal-proximal axis.
Cell reports
Ford MJ,Harwalkar K,Pacis AS,Maunsell H,Wang YC,Badescu D,Teng K,Yamanaka N,Bouchard M,Ragoussis J,Yamanaka Y
Tue Sep 07 00:00:00 EDT 2021
Patient-derived xenografts and organoids model therapy response in prostate cancer.
Nature communications
Karkampouna S,La Manna F,Benjak A,Kiener M,De Menna M,Zoni E,Grosjean J,Klima I,Garofoli A,Bolis M,Vallerga A,Theurillat JP,De Filippo MR,Genitsch V,Keller D,Booij TH,Stirnimann CU,Eng K,Sboner A,Ng CKY,Piscuoglio S,Gray PC,Spahn M,Rubin MA,Thalmann GN,Kruithof-de Julio M
Thu Feb 18 00:00:00 EST 2021
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
Nature
Conlon TM,John-Schuster G,Heide D,Pfister D,Lehmann M,Hu Y,Ertüz Z,Lopez MA,Ansari M,Strunz M,Mayr C,Angelidis I,Ciminieri C,Costa R,Kohlhepp MS,Guillot A,Günes G,Jeridi A,Funk MC,Beroshvili G,Prokosch S,Hetzer J,Verleden SE,Alsafadi H,Lindner M,Burgstaller G,Becker L,Irmler M,Dudek M,Janzen J,Goffin E,Gosens R,Knolle P,Pirotte B,Stoeger T,Beckers J,Wagner D,Singh I,Theis FJ,de Angelis MH,O'Connor T,Tacke F,Boutros M,Dejardin E,Eickelberg O,Schiller HB,Königshoff M,Heikenwalder M,Yildirim AÖ
315-20 was used in In vitro experiments to demonstrate differential expression, signalling, and target gene expression of the lymphotoxin β-receptor in response to cigarette smoke in humans and mice.
Tue Dec 01 00:00:00 EST 2020
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
Nature
Conlon TM,John-Schuster G,Heide D,Pfister D,Lehmann M,Hu Y,Ertüz Z,Lopez MA,Ansari M,Strunz M,Mayr C,Angelidis I,Ciminieri C,Costa R,Kohlhepp MS,Guillot A,Günes G,Jeridi A,Funk MC,Beroshvili G,Prokosch S,Hetzer J,Verleden SE,Alsafadi H,Lindner M,Burgstaller G,Becker L,Irmler M,Dudek M,Janzen J,Goffin E,Gosens R,Knolle P,Pirotte B,Stoeger T,Beckers J,Wagner D,Singh I,Theis FJ,de Angelis MH,O'Connor T,Tacke F,Boutros M,Dejardin E,Eickelberg O,Schiller HB,Königshoff M,Heikenwalder M,Yildirim AÖ
315-20 was used in In vitro experiments to demonstrate differential expression, signalling, and target gene expression of the lymphotoxin β-receptor in response to cigarette smoke in humans and mice.
Tue Dec 01 00:00:00 EST 2020
Cell-type-specific signaling networks in heterocellular organoids.
Nature methods
Qin X,Sufi J,Vlckova P,Kyriakidou P,Acton SE,Li VSW,Nitz M,Tape CJ
Sun Mar 01 00:00:00 EST 2020
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.
Cell metabolism
Bensard CL,Wisidagama DR,Olson KA,Berg JA,Krah NM,Schell JC,Nowinski SM,Fogarty S,Bott AJ,Wei P,Dove KK,Tanner JM,Panic V,Cluntun A,Lettlova S,Earl CS,Namnath DF,Vázquez-Arreguín K,Villanueva CJ,Tantin D,Murtaugh LC,Evason KJ,Ducker GS,Thummel CS,Rutter J
315-20 was used in Cell Culture to study how the earliest stages of colorectal cancer (CRC) initiation are marked by a glycolytic metabolic signature, including downregulation of the mitochondrial pyruvate carrier (MPC), which couples glycolysis and glucose oxidation through mitochondrial pyruvate import, suggetsing that changes in cellular pyruvate metabolism are necessary and sufficient to promote cancer initiation.
Tue Feb 04 00:00:00 EST 2020
A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation.
Cell stem cell
Miao ZF,Adkins-Threats M,Burclaff JR,Osaki LH,Sun JX,Kefalov Y,He Z,Wang ZN,Mills JC
315-20 was used in Tissue/organ culture to show that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor differentiation.
Thu Jun 04 00:00:00 EDT 2020
3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis.
Frontiers in cell and developmental biology
Rabata A,Fedr R,Soucek K,Hampl A,Koledova Z
315-20 was used in Tissue/organ culture to present lung 3D cell culture models as useful tools to study the role and interplay of signaling pathways in postnatal lung development and homeostasis, and we reveal distinct roles for FGF ligands in regulation of mouse lung morphogenesis and differentiation ex vivo.
Mon Sep 28 00:00:00 EDT 2020
Extracellular vesicles transmit epithelial growth factor activity in the intestinal stem cell niche.
Stem cells (Dayton, Ohio)
Oszvald Á,Szvicsek Z,Sándor GO,Kelemen A,Soós AÁ,Pálóczi K,Bursics A,Dede K,Tölgyes T,Buzás EI,Zeöld A,Wiener Z
Sat Feb 01 00:00:00 EST 2020
Extracellular vesicles transmit epithelial growth factor activity in the intestinal stem cell niche.
Stem cells (Dayton, Ohio)
Oszvald Á,Szvicsek Z,Sándor GO,Kelemen A,Soós AÁ,Pálóczi K,Bursics A,Dede K,Tölgyes T,Buzás EI,Zeöld A,Wiener Z
Sat Feb 01 00:00:00 EST 2020
Protocol for Probing Regulated Lysosomal Activity and Function in Living Cells.
STAR protocols
Albrecht LV,Tejeda-Muñoz N,De Robertis EM
315-20 was used in Cell Culture to describe imaging-based protocols for cellular level quantification of functions essential to lysosomal biology.
Fri Dec 18 00:00:00 EST 2020
Protocol for Probing Regulated Lysosomal Activity and Function in Living Cells.
STAR protocols
Albrecht LV,Tejeda-Muñoz N,De Robertis EM
315-20 was used in Cell Culture to describe imaging-based protocols for cellular level quantification of functions essential to lysosomal biology.
Fri Dec 18 00:00:00 EST 2020
Protocol for Probing Regulated Lysosomal Activity and Function in Living Cells.
STAR protocols
Albrecht LV,Tejeda-Muñoz N,De Robertis EM
315-20 was used in Cell Culture to describe imaging-based protocols for cellular level quantification of functions essential to lysosomal biology.
Fri Dec 18 00:00:00 EST 2020
Mechano-modulatory synthetic niches for liver organoid derivation.
Nature communications
Sorrentino G,Rezakhani S,Yildiz E,Nuciforo S,Heim MH,Lutolf MP,Schoonjans K
Fri Jul 10 00:00:00 EDT 2020
Mechano-modulatory synthetic niches for liver organoid derivation.
Nature communications
Sorrentino G,Rezakhani S,Yildiz E,Nuciforo S,Heim MH,Lutolf MP,Schoonjans K
Fri Jul 10 00:00:00 EDT 2020
ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.
Nature communications
Sun X,Peng X,Cao Y,Zhou Y,Sun Y
Fri Jun 12 00:00:00 EDT 2020
Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas.
Nature communications
Sudhakar JN,Lu HH,Chiang HY,Suen CS,Hwang MJ,Wu SY,Shen CN,Chang YM,Li FA,Liu FT,Shui JW
Thu Aug 27 00:00:00 EDT 2020
Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines.
Nature communications
Boon R,Kumar M,Tricot T,Elia I,Ordovas L,Jacobs F,One J,De Smedt J,Eelen G,Bird M,Roelandt P,Doglioni G,Vriens K,Rossi M,Vazquez MA,Vanwelden T,Chesnais F,El Taghdouini A,Najimi M,Sokal E,Cassiman D,Snoeys J,Monshouwer M,Hu WS,Lange C,Carmeliet P,Fendt SM,Verfaillie CM
Fri Mar 13 00:00:00 EDT 2020
APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes.
Scientific reports
Parker TW,Neufeld KL
Wed Feb 19 00:00:00 EST 2020
Oncogenic Serine 45-Deleted β-Catenin Remains Susceptible to Wnt Stimulation and APC Regulation in Human Colonocytes.
Cancers
Parker TW,Rudeen AJ,Neufeld KL
315-20 was used in In vitro experiments to expand the current understanding of Wnt/β-catenin signaling and provide an example of a β-catenin mutation that maintains some ability to respond to Wnt, a possible key to establishing β-catenin activity that is just-right" for tumorigenesis."
Thu Jul 30 00:00:00 EDT 2020
Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain.
Cell
Kalamakis G,Brüne D,Ravichandran S,Bolz J,Fan W,Ziebell F,Stiehl T,Catalá-Martinez F,Kupke J,Zhao S,Llorens-Bobadilla E,Bauer K,Limpert S,Berger B,Christen U,Schmezer P,Mallm JP,Berninger B,Anders S,Del Sol A,Marciniak-Czochra A,Martin-Villalba A
Thu Mar 07 00:00:00 EST 2019
PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.
The Journal of clinical investigation
Li Y,Hu Q,Li C,Liang K,Xiang Y,Hsiao H,Nguyen TK,Park PK,Egranov SD,Ambati CR,Putluri N,Hawke DH,Han L,Hung MC,Danesh FR,Yang L,Lin C
Fri Mar 01 00:00:00 EST 2019
Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation.
Proceedings of the National Academy of Sciences of the United States of America
Albrecht LV,Bui MH,De Robertis EM
Tue Feb 19 00:00:00 EST 2019
Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins.
Proceedings of the National Academy of Sciences of the United States of America
Tejeda-Muñoz N,Albrecht LV,Bui MH,De Robertis EM
Tue May 21 00:00:00 EDT 2019
GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump.
Science signaling
Schneditz G,Elias JE,Pagano E,Zaeem Cader M,Saveljeva S,Long K,Mukhopadhyay S,Arasteh M,Lawley TD,Dougan G,Bassett A,Karlsen TH,Kaser A,Kaneider NC
315-20 was used in Cell Culture to investigate the effects of GPR35 on the sodium potassium pump and metabolic activity in macrophages and intestinal epithelial cells,.
Tue Jan 01 00:00:00 EST 2019
Connexin43 enhances Wnt and PGE2-dependent activation of β-catenin in osteoblasts.
Pflugers Archiv : European journal of physiology
Gupta A,Chatree S,Buo AM,Moorer MC,Stains JP
315-20 was used in In vitro experiments to investigate connexin43 downstream pathways of intercellular communication.
Sun Sep 01 00:00:00 EDT 2019
Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation.
Nature communications
Kim S,Han S,Kim Y,Kim HS,Gu YR,Kang D,Cho Y,Kim H,Lee J,Seo Y,Chang MJ,Chang CB,Kang SB,Kim JH
Fri Oct 25 00:00:00 EDT 2019
Long noncoding RNA ANCR inhibits the differentiation of mesenchymal stem cells toward definitive endoderm by facilitating the association of PTBP1 with ID2.
Cell death & disease
Li J,Yang Y,Fan J,Xu H,Fan L,Li H,Zhao RC
Mon Jun 24 00:00:00 EDT 2019
Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia.
Nature communications
Soutto M,Chen Z,Bhat AA,Wang L,Zhu S,Gomaa A,Bates A,Bhat NS,Peng D,Belkhiri A,Piazuelo MB,Washington MK,Steven XC,Peek R,El-Rifai W
Wed Jul 10 00:00:00 EDT 2019
Comparative transcriptome analysis of hESC- and iPSC-derived lentoid bodies.
Scientific reports
Ali M,Kabir F,Thomson JJ,Ma Y,Qiu C,Delannoy M,Khan SY,Riazuddin SA
Fri Dec 06 00:00:00 EST 2019
Mesenchyme-free expansion and transplantation of adult alveolar progenitor cells: steps toward cell-based regenerative therapies.
NPJ Regenerative medicine
Weiner AI,Jackson SR,Zhao G,Quansah KK,Farshchian JN,Neupauer KM,Littauer EQ,Paris AJ,Liberti DC,Scott Worthen G,Morrisey EE,Vaughan AE
Tue Sep 29 00:00:00 EDT 2020
ERAD-dependent control of the Wnt secretory factor Evi.
The EMBO journal
Glaeser K,Urban M,Fenech E,Voloshanenko O,Kranz D,Lari F,Christianson JC,Boutros M
315-20 was used in In vitro experiments to study how abundance of the Wnt cargo receptor Evi (Wls/GPR177), which is required for Wnt protein secretion, is also regulated by the UPS through endoplasmic reticulum (ER)-associated degradation (ERAD).
Thu Feb 15 00:00:00 EST 2018
Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers.
Autophagy
Nàger M,Sallán MC,Visa A,Pushparaj C,Santacana M,Macià A,Yeramian A,Cantí C,Herreros J
315-20 was used in Cell Culture to study the impact of inhibiting WNT signaling on autophagy in glioblastoma (GBM).
Thu Mar 07 00:00:00 EST 2019
Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking.
Proceedings of the National Academy of Sciences of the United States of America
Albrecht LV,Ploper D,Tejeda-Muñoz N,De Robertis EM
Tue Jun 05 00:00:00 EDT 2018
Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy.
Nature communications
Zhang K,Zhang Y,Gu L,Lan M,Liu C,Wang M,Su Y,Ge M,Wang T,Yu Y,Liu C,Li L,Li Q,Zhao Y,Yu Z,Wang F,Li N,Meng Q
Mon Dec 03 00:00:00 EST 2018
Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells.
PloS one
Sambathkumar R,Akkerman R,Dastidar S,Roelandt P,Kumar M,Bajaj M,Mestre Rosa AR,Helsen N,Vanslembrouck V,Kalo E,Khurana S,Laureys J,Gysemans C,Faas MM,de Vos P,Verfaillie CM
315-20 was used in Cell Culture to investigate 14 transcription factors in multipotent adult progenitor cell reprogramming for hepatocyte and endocrine pacreatic-like cell culture.
Tue Jul 31 00:00:00 EDT 2018
A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability.
Cell reports
Vallon M,Yuki K,Nguyen TD,Chang J,Yuan J,Siepe D,Miao Y,Essler M,Noda M,Garcia KC,Kuo CJ
315-20 was used in Cell Culture to demonstrate that primarily the GPR124 ectodomain, but not its transmembrane and intracellular domains, mediates RECK/WNT7-induced canonical Wnt signalling.
Tue Oct 09 00:00:00 EDT 2018
Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling.
The EMBO journal
Guo YC,Wang MY,Zhang SW,Wu YS,Zhou CC,Zheng RX,Shao B,Wang Y,Xie L,Liu WQ,Sun NY,Jing JJ,Ye L,Chen QM,Yuan Q
315-20 was used in Cell Culture to demonstrate that USP34 stabilizes both Smad1 and RUNX2 and that depletion of Smurf1 restores the osteogenic potential of Usp34-deficient MSCs in vitro Taken together, our data indicate that USP34 is required for osteogenic differentiation and bone formation.
Mon Oct 15 00:00:00 EDT 2018
ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.
Frontiers in immunology
Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW
315-20 was used in Cell Culture to identify the mechanism by which activating transcription factor 3 mediates a cross-regulation in the barrier to maintain mucosal homeostasis and immunity.
Thu Sep 26 00:00:00 EDT 2019
FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation.
EMBO reports
Ehyai S,Miyake T,Williams D,Vinayak J,Bayfield MA,McDermott JC
315-20 was used in In vitro experiments to present evidence that β-catenin fulfills a previously unrecognized function in translational repression.
Sat Dec 01 00:00:00 EST 2018
Cytoglobin affects tumorigenesis and the expression of ulcerative colitis-associated genes under chemically induced colitis in mice.
Scientific reports
Yassin M,Kissow H,Vainer B,Joseph PD,Hay-Schmidt A,Olsen J,Pedersen AE
Wed May 02 00:00:00 EDT 2018
BMP and WNT signalling cooperate through LEF1 in the neuronal specification of adult hippocampal neural stem and progenitor cells.
Scientific reports
Armenteros T,Andreu Z,Hortigüela R,Lie DC,Mira H
Mon Jun 18 00:00:00 EDT 2018
Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.
The Journal of experimental medicine
Matsuzawa-Ishimoto Y,Shono Y,Gomez LE,Hubbard-Lucey VM,Cammer M,Neil J,Dewan MZ,Lieberman SR,Lazrak A,Marinis JM,Beal A,Harris PA,Bertin J,Liu C,Ding Y,van den Brink MRM,Cadwell K
Mon Dec 04 00:00:00 EST 2017
Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification.
Cell death and differentiation
Vicinanza C,Aquila I,Scalise M,Cristiano F,Marino F,Cianflone E,Mancuso T,Marotta P,Sacco W,Lewis FC,Couch L,Shone V,Gritti G,Torella A,Smith AJ,Terracciano CM,Britti D,Veltri P,Indolfi C,Nadal-Ginard B,Ellison-Hughes GM,Torella D
Fri Dec 01 00:00:00 EST 2017
C9ORF135 encodes a membrane protein whose expression is related to pluripotency in human embryonic stem cells.
Scientific reports
Zhou S,Liu Y,Ma Y,Zhang X,Li Y,Wen J
Mon Mar 27 00:00:00 EDT 2017
Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme.
Nature communications
Li A,Figueroa S,Jiang TX,Wu P,Widelitz R,Nie Q,Chuong CM
Fri Jan 20 00:00:00 EST 2017
Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.
Immunity
Bhattacharya N,Yuan R,Prestwood TR,Penny HL,DiMaio MA,Reticker-Flynn NE,Krois CR,Kenkel JA,Pham TD,Carmi Y,Tolentino L,Choi O,Hulett R,Wang J,Winer DA,Napoli JL,Engleman EG
Tue Sep 20 00:00:00 EDT 2016
Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Xu Z,Robitaille AM,Berndt JD,Davidson KC,Fischer KA,Mathieu J,Potter JC,Ruohola-Baker H,Moon RT
Tue Oct 18 00:00:00 EDT 2016
Dysregulation of Wnt-Signaling and a Candidate Set of miRNAs Underlie the Effect of Metformin on Neural Crest Cell Development.
Stem cells (Dayton, Ohio)
Banerjee P,Dutta S,Pal R
Mon Feb 01 00:00:00 EST 2016
TNIK inhibition abrogates colorectal cancer stemness.
Nature communications
Masuda M,Uno Y,Ohbayashi N,Ohata H,Mimata A,Kukimoto-Niino M,Moriyama H,Kashimoto S,Inoue T,Goto N,Okamoto K,Shirouzu M,Sawa M,Yamada T
Fri Aug 26 00:00:00 EDT 2016
Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-β Signaling.
Journal of cellular biochemistry
Carthy JM,Engström U,Heldin CH,Moustakas A
315-20 was used in In vitro experiments to find that treatment of cultured fibroblasts with recombinant Wnt3a induced immediate activation of TGF-β and BMP signaling and this activity appeared to be independent of the Wnt ligand itself.
Fri Apr 01 00:00:00 EDT 2016
H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro.
Stem cell reports
Vanhove J,Pistoni M,Welters M,Eggermont K,Vanslembrouck V,Helsen N,Boon R,Najimi M,Sokal E,Collas P,Voncken JW,Verfaillie CM
Tue Aug 09 00:00:00 EDT 2016
MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.
Proceedings of the National Academy of Sciences of the United States of America
Ploper D,Taelman VF,Robert L,Perez BS,Titz B,Chen HW,Graeber TG,von Euw E,Ribas A,De Robertis EM
Tue Feb 03 00:00:00 EST 2015
CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer.
Proceedings of the National Academy of Sciences of the United States of America
Cheah MT,Chen JY,Sahoo D,Contreras-Trujillo H,Volkmer AK,Scheeren FA,Volkmer JP,Weissman IL
Tue Apr 14 00:00:00 EDT 2015
The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Yorgan TA,Peters S,Jeschke A,Benisch P,Jakob F,Amling M,Schinke T
315-20 was used in Cell Culture to investigate the effects of Sclerostin overexpression and its interactions with Lrp5 during bone formation in mice.
Wed Jul 01 00:00:00 EDT 2015
Multipotent caudal neural progenitors derived from human pluripotent stem cells that give rise to lineages of the central and peripheral nervous system.
Stem cells (Dayton, Ohio)
Denham M,Hasegawa K,Menheniott T,Rollo B,Zhang D,Hough S,Alshawaf A,Febbraro F,Ighaniyan S,Leung J,Elliott DA,Newgreen DF,Pera MF,Dottori M
Mon Jun 01 00:00:00 EDT 2015
Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells.
Stem cell reports
Siller R,Greenhough S,Naumovska E,Sullivan GJ
Tue May 12 00:00:00 EDT 2015
WNT5A transforms intestinal CD8αα⁺ IELs into an unconventional phenotype with pro-inflammatory features.
BMC gastroenterology
Zhao D,Xu A,Dai Z,Peng J,Zhu M,Shen J,Zheng Q,Ran Z
315-20 was used in Functional assay to study the role of intestinal intraepithelial lymphocytes (IELs) in immune status determination to demonstrate that canonical and non-canonical WNT signals act in opposing manners concerning determining CD8αα(+) IELs immune status which could be targeted in inflammatory bowel disease.
Thu Dec 10 00:00:00 EST 2015
Analysis of Wnt signalling dynamics during colon crypt development in 3D culture.
Scientific reports
Tan CW,Hirokawa Y,Burgess AW
Thu Jun 18 00:00:00 EDT 2015
CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells.
Stem cell reports
Kido T,Koui Y,Suzuki K,Kobayashi A,Miura Y,Chern EY,Tanaka M,Miyajima A
Tue Oct 13 00:00:00 EDT 2015
Hippo pathway activity influences liver cell fate.
Cell
Yimlamai D,Christodoulou C,Galli GG,Yanger K,Pepe-Mooney B,Gurung B,Shrestha K,Cahan P,Stanger BZ,Camargo FD
Thu Jun 05 00:00:00 EDT 2014
Long-lived intestinal tuft cells serve as colon cancer-initiating cells.
The Journal of clinical investigation
Westphalen CB,Asfaha S,Hayakawa Y,Takemoto Y,Lukin DJ,Nuber AH,Brandtner A,Setlik W,Remotti H,Muley A,Chen X,May R,Houchen CW,Fox JG,Gershon MD,Quante M,Wang TC
Sat Mar 01 00:00:00 EST 2014
Luminal microbes promote monocyte-stem cell interactions across a healthy colonic epithelium.
Journal of immunology (Baltimore, Md. : 1950)
Skoczek DA,Walczysko P,Horn N,Parris A,Clare S,Williams MR,Sobolewski A
Tue Jul 01 00:00:00 EDT 2014
The tumor suppressor Smad4/DPC4 is regulated by phosphorylations that integrate FGF, Wnt, and TGF-β signaling.
Cell reports
Demagny H,Araki T,De Robertis EM
Thu Oct 23 00:00:00 EDT 2014
The tumor suppressor Smad4/DPC4 is regulated by phosphorylations that integrate FGF, Wnt, and TGF-β signaling.
Cell reports
Demagny H,Araki T,De Robertis EM
Thu Oct 23 00:00:00 EDT 2014
Lithium rescues synaptic plasticity and memory in Down syndrome mice.
The Journal of clinical investigation
Contestabile A,Greco B,Ghezzi D,Tucci V,Benfenati F,Gasparini L
Tue Jan 01 00:00:00 EST 2013
LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1.
Proceedings of the National Academy of Sciences of the United States of America
Ren S,Johnson BG,Kida Y,Ip C,Davidson KC,Lin SL,Kobayashi A,Lang RA,Hadjantonakis AK,Moon RT,Duffield JS
Tue Jan 22 00:00:00 EST 2013
Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway.
Proceedings of the National Academy of Sciences of the United States of America
Liu B,Staron M,Hong F,Wu BX,Sun S,Morales C,Crosson CE,Tomlinson S,Kim I,Wu D,Li Z
Tue Apr 23 00:00:00 EDT 2013
Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3.
Stem cells (Dayton, Ohio)
Przybyla LM,Theunissen TW,Jaenisch R,Voldman J
Sat Jun 01 00:00:00 EDT 2013
Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Oderup C,LaJevic M,Butcher EC
Sat Jun 15 00:00:00 EDT 2013
Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells.
Scientific reports
McMurray RJ,Wann AK,Thompson CL,Connelly JT,Knight MM
Wed Dec 18 00:00:00 EST 2013
Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells.
The Journal of biological chemistry
James RG,Bosch KA,Kulikauskas RM,Yang PT,Robin NC,Toroni RA,Biechele TL,Berndt JD,von Haller PD,Eng JK,Wolf-Yadlin A,Chien AJ,Moon RT
Fri Nov 29 00:00:00 EST 2013
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells.
Nature communications
Voloshanenko O,Erdmann G,Dubash TD,Augustin I,Metzig M,Moffa G,Hundsrucker C,Kerr G,Sandmann T,Anchang B,Demir K,Boehm C,Leible S,Ball CR,Glimm H,Spang R,Boutros M
Thu Jun 12 00:00:00 EDT 2014
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells.
Nature communications
Voloshanenko O,Erdmann G,Dubash TD,Augustin I,Metzig M,Moffa G,Hundsrucker C,Kerr G,Sandmann T,Anchang B,Demir K,Boehm C,Leible S,Ball CR,Glimm H,Spang R,Boutros M
Thu Jun 12 00:00:00 EDT 2014
Role of TAZ as mediator of Wnt signaling.
Cell
Azzolin L,Zanconato F,Bresolin S,Forcato M,Basso G,Bicciato S,Cordenonsi M,Piccolo S
Fri Dec 21 00:00:00 EST 2012
Transposon-mediated BAC transgenesis in human ES cells.
Nucleic acids research
Rostovskaya M,Fu J,Obst M,Baer I,Weidlich S,Wang H,Smith AJ,Anastassiadis K,Stewart AF
Mon Oct 01 00:00:00 EDT 2012
Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4.
Proceedings of the National Academy of Sciences of the United States of America
Davidson KC,Adams AM,Goodson JM,McDonald CE,Potter JC,Berndt JD,Biechele TL,Taylor RJ,Moon RT
Tue Mar 20 00:00:00 EDT 2012
Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion.
Stem cells translational medicine
Hasegawa K,Yasuda SY,Teo JL,Nguyen C,McMillan M,Hsieh CL,Suemori H,Nakatsuji N,Yamamoto M,Miyabayashi T,Lutzko C,Pera MF,Kahn M
Sun Jan 01 00:00:00 EST 2012
Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells.
Stem cells (Dayton, Ohio)
Nefzger CM,Su CT,Fabb SA,Hartley BJ,Beh SJ,Zeng WR,Haynes JM,Pouton CW
Sun Jul 01 00:00:00 EDT 2012
WNT3A induces a contractile and secretory phenotype in cultured vascular smooth muscle cells that is associated with increased gap junction communication.
Laboratory investigation; a journal of technical methods and pathology
Carthy JM,Luo Z,McManus BM
315-20 was used in Cell Culture to study the effect on Wnt ligands on the structure and function of vascular cells by treating vascular smooth muscle cells with recombinant Wnt3a and observe changes in the cell phenotype.
Wed Feb 01 00:00:00 EST 2012
Tcf7 is an important regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line.
PLoS genetics
Wu JQ,Seay M,Schulz VP,Hariharan M,Tuck D,Lian J,Du J,Shi M,Ye Z,Gerstein M,Snyder MP,Weissman S
Tue Sep 04 00:00:00 EDT 2012
Wnt3a induces myofibroblast differentiation by upregulating TGF-β signaling through SMAD2 in a β-catenin-dependent manner.
PloS one
Carthy JM,Garmaroudi FS,Luo Z,McManus BM
Mon Sep 12 00:00:00 EDT 2011
