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Product Details
RP-87793
Product Specifications
Species
Pig
Expression System
E. coli
Amino acid sequence
MHKCDITLQE IIKTLNILTA RKNSCMELPV TDVFAAPENT TEKETFCRAS TVLRHIYRHH TCMKSLLSGL DRNLSSMANM TCSVHEAKKS TLKDFLERLK TIMKEKYSKC
Molecular weight
12.7 kDa
Class
Recombinant
Type
Protein
Purity
≥95% by SDS-Page
Endotoxin concentration
≤0.1 EU/µg
Activity
ED50 ≤ 2 ng/mL; determined by the dose-dependent proliferation of TF-1 cells.
Conjugate
Form
Lyophilized
Purification
purified
Storage buffer
10mM sodium phosphate, pH 7.5
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Animal Origin Free
Reconstitution: Sterile Water at 0.1 mg/mL
Target Information
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell stimulatory factor 1; BSF-1; cytokine; H-IL-4; IL-4; ILN; Interleukin; Interleukin-4; Interleukin4; Lymphocyte stimulatory factor 1; M-IL-4; MGC79402
Gene Aliases: IL4
UniProt ID: (Pig) Q04745
Entrez Gene ID: (Pig) 397225
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