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Product Details
RRMCP110
Applications
Tested Dilution
Publications
Product Specifications
Species
Rat
Expression System
E. coli
Amino acid sequence
Rat CCL2 recombinant protein contains 125 amino acids
Molecular weight
14 kDa
Class
Recombinant
Type
Protein
Purity
>97% by SDS-PAGE and HPLC analyses
Endotoxin concentration
<1 EU/µg
Activity
Maximal chemotactic activity on human monocytes is achieved at 100 ng/mL.
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
RRMCP110 contains 125 amino acid residues. Endotoxin level is <1 EU/ug.
Purity: >97% pure by SDS-PAGE and HPLC analyses.
Activity: The maximal chemotactic activity on human monocytes is achieved at 100 ng/mL.
Reconstitution and Dilution: Reconstitute in distilled water to a concentration of 100 µg/mL. After reconstitution, dilute cytokine in a neutral buffer containing carrier protein such as 5-10% FBS or 1-4% high purity BSA (fatty acid free fraction V).
Lyophilized product is stable until expiration if stored desiccated below 0ºC. Cytokines diluted as indicated above should be divided into aliquots and stored at -70ºC. Recombinant proteins should be stored at concentrations >500 ng/mL to reduce loss of activity.
Target Information
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-C motif chemokine 2; H-MCP-1; immediate-early serum-responsive JE protein; Immediate-early serum-responsive protein JE; MCP-1; MGC9434; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; Monocyte chemotactic protein 1; RP23-350G1.3; small inducible cytokine A2; small inducible gene JE; Small-inducible cytokine A2
Gene Aliases: Ccl2; Je; MCP-1; Mcp1; Scya2; Sigje
UniProt ID: (Rat) P14844
Entrez Gene ID: (Rat) 24770
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