Gibco

Rat CXCL12 (SDF-1a) Recombinant Protein, PeproTech®

Product Details

400-32A-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 6 publications 6 publications

Miscellaneous PubMed (Misc)

View 4 publications 4 publications

Product Specifications

Species

Rat

Published species

Human, Rat

Expression System

E. coli

Amino acid sequence

KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKSNNRQVC IDPKLKWIQE YLDKALNK

Molecular weight

7.9 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 50.0-100.0 ng/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Rat SDF-1alpha is a 7.9 kDa protein containing 68 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ACT-1004-1239, a first-in-class CXCR7 antagonist with both immunomodulatory and promyelinating effects for the treatment of inflammatory demyelinating diseases.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Pouzol L,Baumlin N,Sassi A,Tunis M,Marrie J,Vezzali E,Farine H,Mentzel U,Martinic MM

Mon Mar 01 00:00:00 EST 2021

CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility.

eLife

Festa LK,Irollo E,Platt BJ,Tian Y,Floresco S,Meucci O

400-32A was used in Cell Culture to report that the chemokine CXCL112 recoups both cognitive performance and synaptodendritic health in a rodent model of HIV-associated neurocognitive disorders (HAND), which recapitulates the neuroinflammatory state of virally controlled individuals and the associated structural/functional deficiencies.

Thu Jan 23 00:00:00 EST 2020

Human Cartilage-Derived Progenitors Resist Terminal Differentiation and Require CXCR4 Activation to Successfully Bridge Meniscus Tissue Tears.

Stem cells (Dayton, Ohio)

Jayasuriya CT,Twomey-Kozak J,Newberry J,Desai S,Feltman P,Franco JR,Li N,Terek R,Ehrlich MG,Owens BD

Tue Jan 01 00:00:00 EST 2019

Human Cartilage-Derived Progenitors Resist Terminal Differentiation and Require CXCR4 Activation to Successfully Bridge Meniscus Tissue Tears.

Stem cells (Dayton, Ohio)

Jayasuriya CT,Twomey-Kozak J,Newberry J,Desai S,Feltman P,Franco JR,Li N,Terek R,Ehrlich MG,Owens BD

Tue Jan 01 00:00:00 EST 2019

Umbilical cord extracts improve osteoporotic abnormalities of bone marrow-derived mesenchymal stem cells and promote their therapeutic effects on ovariectomised rats.

Scientific reports

Saito A,Nagaishi K,Iba K,Mizue Y,Chikenji T,Otani M,Nakano M,Oyama K,Yamashita T,Fujimiya M

Thu Jan 18 00:00:00 EST 2018

SDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart.

Scientific reports

Renko O,Tolonen AM,Rysä J,Magga J,Mustonen E,Ruskoaho H,Serpi R

Thu Jan 18 00:00:00 EST 2018

Comparative miRNA-Based Fingerprinting Reveals Biological Differences in Human Olfactory Mucosa- and Bone-Marrow-Derived Mesenchymal Stromal Cells.

Stem cell reports

Lindsay SL,Johnstone SA,McGrath MA,Mallinson D,Barnett SC

Tue May 10 00:00:00 EDT 2016

Development of decellularized aortic valvular conduit coated by heparin-SDF-1α multilayer.

The Annals of thoracic surgery

Zhou J,Ye X,Wang Z,Liu J,Zhang B,Qiu J,Sun Y,Li H,Zhao Q

400-32A was used in Immunohistochemistry-immunofluorescence to indicate that heparin-SDF-1α multilayer film can be used to cover the decellularized aortic valvular graft to decrease platelet adhesion while precipitating regeneration of the decellularized aortic valve allograft in vivo.

Sun Feb 01 00:00:00 EST 2015

CXCR4 receptor overexpression in mesenchymal stem cells facilitates treatment of acute lung injury in rats.

The Journal of biological chemistry

Yang JX,Zhang N,Wang HW,Gao P,Yang QP,Wen QP

Fri Jan 23 00:00:00 EST 2015

Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration.

Scientific reports

Chen D,Xia Y,Zuo K,Wang Y,Zhang S,Kuang D,Duan Y,Zhao X,Wang G

Wed Nov 18 00:00:00 EST 2015

Neuronal ferritin heavy chain and drug abuse affect HIV-associated cognitive dysfunction.

The Journal of clinical investigation

Pitcher J,Abt A,Myers J,Han R,Snyder M,Graziano A,Festa L,Kutzler M,Garcia F,Gao WJ,Fischer-Smith T,Rappaport J,Meucci O

Sat Feb 01 00:00:00 EST 2014

Bioinformatics

Protein Aliases: C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); CXC; CXC motif chemokine; CXCL; H-SDF-1-alpha; SDF 1 a; SDF 1 alpha; SDF 1α; SDF-1 gamma; SDF1 alpha; SDF1α; stromal cell-derived factor 1; stromal cell-derived factor-1 alpha; stromal cell-derived factor-1 gamma

Rat CXCL12 (SDF-1a) Recombinant Protein, PeproTech®

Product Details

400-32A-10UG

Western Blot (WB)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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