Gibco

Rat CXCL2 (GRO beta) Recombinant Protein, PeproTech®

Product Details

400-11-25UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

View 3 publications 3 publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 4 publications 4 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species

Rat

Published species

Human, Rat

Expression System

E. coli

Amino acid sequence

VVVASELRCQ CLTTLPRVDF KNIQSLTVTP PGPHCAQTEV IATLKDGHEV CLNPEAPLVQ RIVQKILNKG KAN

Molecular weight

7.9 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to chemoattract rat neutrophils using a concentration range of 10.0-100.0 ng/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Rat GRO-beta/MIP-2 is a 7.9 kDa protein consisting of 73 amino acids, including the 'ELR' motif common to the CXC chemokine family that binds to CXCR1 or CXCR2.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan.

Journal of immunology (Baltimore, Md. : 1950)

Abu-Taha M,Rius C,Hermenegildo C,Noguera I,Cerda-Nicolas JM,Issekutz AC,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ

Wed Jul 15 00:00:00 EDT 2009

A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles.

Blood

Mateo T,Naim Abu Nabah Y,Losada M,Estellés R,Company C,Bedrina B,Cerdá-Nicolás JM,Poole S,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ

Sat Sep 15 00:00:00 EDT 2007

The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner.

Blood

Burdon PC,Martin C,Rankin SM

Tue Mar 15 00:00:00 EST 2005

Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines.

Circulation

Nabah YN,Mateo T,Estellés R,Mata M,Zagorski J,Sarau H,Cortijo J,Morcillo EJ,Jose PJ,Sanz MJ

Tue Dec 07 00:00:00 EST 2004

Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.

Proceedings of the National Academy of Sciences of the United States of America

Bertini R,Allegretti M,Bizzarri C,Moriconi A,Locati M,Zampella G,Cervellera MN,Di Cioccio V,Cesta MC,Galliera E,Martinez FO,Di Bitondo R,Troiani G,Sabbatini V,D'Anniballe G,Anacardio R,Cutrin JC,Cavalieri B,Mainiero F,Strippoli R,Villa P,Di Girolamo M,Martin F,Gentile M,Santoni A,Corda D,Poli G,Mantovani A,Ghezzi P,Colotta F

Tue Aug 10 00:00:00 EDT 2004

Ligand-independent CXCR2 dimerization.

The Journal of biological chemistry

Trettel F,Di Bartolomeo S,Lauro C,Catalano M,Ciotti MT,Limatola C

Fri Oct 17 00:00:00 EDT 2003

The Journal of biological chemistry

Limatola C,Mileo AM,Giovannelli A,Vacca F,Ciotti MT,Mercanti D,Santoni A,Eusebi F

Fri Dec 17 00:00:00 EST 1999

Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli.

The Journal of experimental medicine

McWilliam AS,Napoli S,Marsh AM,Pemper FL,Nelson DJ,Pimm CL,Stumbles PA,Wells TN,Holt PG

Sun Dec 01 00:00:00 EST 1996

Bioinformatics

Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 2; CC motif chemokine; CCmotif chemokine; CINC-3; CXC; CXC motif chemokine; CXCL; Cytokine-induced neutrophil chemoattractant 3; GRO b; gro beta; GRO β; GRObeta; GROβ; Macrophage inflammatory protein 2; MIP 2 a; MIP 2 alpha; MIP 2 α; MIP2; MIP2 a; MIP2 α; small inducible cytokine subfamily, member 2

Rat CXCL2 (GRO beta) Recombinant Protein, PeproTech®

Product Details

400-11-25UG

Western Blot (WB)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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