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Product Details
RP-87667
Applications
Tested Dilution
Publications
Product Specifications
Species
Virus
Expression System
E. coli
Amino acid sequence
SARS-CoV-2 ORF3a, amino acids 126-275
Molecular weight
22 kDa
Class
Recombinant
Type
Protein
Purity
>95% by reducing SDS-PAGE
Conjugate
Form
Liquid
Concentration
1.8 mg/mL
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
ORF3A forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: COVID-19 ORF3A; COVID19 ORF3A; ORF3A; SARS-CoV-2 Open Reading Frame 3A; SARS-COV2 ORF3A
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