ATP6V1F Proteins

Protein Information

ATP6V1F encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein.

Synonyms

1110004G16Rik; adenosinetriphosphatase 14k chain; ATP6S14; ATP6V1F; ATPase H+ transporting V1 subunit F; ATPase, H transporting, lysosomal V1 subunit F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F; ATPase, H+ transporting, lysosomal V1 subunit F; ATPase, H+ transporting, V1 subunit F; ATPase, vacuolar, 14 kD; H(+)-transporting two-sector ATPase, 14kD subunit; vacuolar ATP synthase subunit F; vacuolar proton pump F subunit; vacuolar proton pump subunit F; VATF; V-ATPase 14 kDa subunit; V-ATPase F subunit; V-ATPase subunit F; Vma7; V-type proton ATPase subunit F; v-type proton ATPase subunit F-like