Getting Started in Cryo-EM eBook

Cryo-electron microscopy (cryo-EM) is easier to adopt and more affordable than ever before. Learn how to get started in cryo-EM and overcome the current limitations of traditional techniques, including X-ray crystallography and nuclear magnetic resonance (NMR), with our Getting Started in Cryo-EM eBook.

The eBook includes:

• An introduction to cryo-EM and an overview of key methods: single particle analysis, microcrystal electron diffraction, and cryo-tomography
• Helpful information on how to bring cryo-EM into your laboratory
• Examples of how cryo-EM is used to answer important scientific questions with case studies of challenging proteins:
  • SARS-CoV-2 spike glycoprotein variants
  • Visualization of enterovirus virion assembly
  • Structural insights into p53 mutations
  • Visualization of misfolded tau protein filaments